http://identifiers.org/biomodels.db/MODEL1310110051#_9f0b459d_0891_4dc3_8e1d_db9cea76f180
initial amount: NaN
is: SBO:0000252
is: Q9BYV1
is encoded by: hsa:64902
constant: false
initial concentration: NaN
boundary condition: true
name: AGXT2
has only substance units: false
type: Species

metaM 3deccrn e
is: HMDB02250
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C17H33NO5 CHARGE: 0
name: 3-hydroxydecanoylcarnitine
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_9e841b1f_d09a_4360_836b_01062ce047aa
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54995
constant: false
is: Q9NWU1
name: OXSM
boundary condition: true
has only substance units: false

metaR r2197
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
type: Reaction

metaR ADRNCPT1
is: SBO:0000176
product: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false

metaR HTDCRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaM sphmyln hs c
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
is: CHEBI:58216
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_428c906c_8661_4b1d_a96f_517bdef666fb
boundary condition: true
name: SLC27A2
initial amount: NaN
is: O14975
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:11001
constant: false

metaM so3 m
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00240
has only substance units: false
is: CHEBI:17137
boundary condition: false
type: Species
name: hydrogensulfite
initial concentration: 1.0
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094

metaM xol7ah3 m
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol
boundary condition: false
is: CHEBI:28540
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444

http://identifiers.org/biomodels.db/MODEL1310110051#_12ce652c_abd8_44c3_a172_9a3cd9a8e9ba
boundary condition: true
name: ALDH3B1
has only substance units: false
is encoded by: hsa:221
constant: false
type: Species
initial amount: NaN
is: P43353
initial concentration: NaN
is: SBO:0000252

metaM nadp x
is: CHEBI:58349
initial amount: NaN
type: Species
is: HMDB00217
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM HC00250 c
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide

http://identifiers.org/biomodels.db/MODEL1310110051#_95ff7a65_13c4_4fb0_91f0_cb5715040913
is encoded by: hsa:1582
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: CYP8B1
boundary condition: true
is: Q9UNU6
constant: false
type: Species
has only substance units: false

metaR r2198
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185

metaR F1Atg
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
reversible: true
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: F1alpha transport (from golgi to lysosome)
type: Reaction

metaR PNTEH
is described by: ECO:0000269
reactant: MODEL1310110051#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
fast: false
kinetic law: MODEL1310110051#
name: Hydrolase Class ( RXN R02973)
product: MODEL1310110051#
reversible: false

metaR RE1447M
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447

http://identifiers.org/biomodels.db/MODEL1310110051#_795707e0_e70a_41f5_ba80_ca930e75cf43
initial amount: NaN
type: Species
name: EGFR
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P00533
constant: false
initial concentration: NaN
is encoded by: hsa:1956

metaR COAtr
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
name: COA transporter, endoplasmic reticulum

metaM 3aib D m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: D-3-Amino-isobutanoate
is: HMDB02299
constant: false
boundary condition: false
is: C03265

http://identifiers.org/biomodels.db/MODEL1310110051#_af00f206_4f8d_4a2b_9081_210fee2d8fc3
is encoded by: hsa:AA664770
constant: false
name: _AA664770_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaR r0267
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
fast: false
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
modifier: MODEL1310110051#

metaR RE1531M
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
name: RE1531
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_e8e481e0_c385_4ddf_ad58_a766bc5d082d
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10606
constant: false
initial concentration: NaN
type: Species
is: P22234
name: PAICS
boundary condition: true
initial amount: NaN

metaR r2195
product: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110051#

metaR L LACt4r
reversible: true
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: L-lactate reversible transport via sodium symport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ada1e4c4_5f5d_4902_bdad_5c3c3eed99d7
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:23464
initial amount: NaN
name: GCAT
type: Species
is: E2QC23
boundary condition: true

metaR HISCAT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM 3deccrn c
is: HMDB00651
is: SBO:0000247
notes: FORMULA: C17H33NO5 CHARGE: 0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: 3-hydroxydecanoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110051#_6981d3c3_0b5b_4ec8_90cc_6847a6dafe5d
name: MTHFD1
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:4522
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P11586

metaR PCHOLP hs
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
type: Reaction
modifier: MODEL1310110051#
name: choline phosphatase
reversible: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
reactant: MODEL1310110051#

metaR RE1447N
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
name: RE1447
reversible: true
product: MODEL1310110051#

metaR r0119
reactant: MODEL1310110051#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.1.3.14
fast: false
reversible: false
product: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:

metaR PETOHMm hs
reversible: false
modifier: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
name: phosphatidylethanolamine N-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.17
is: SBO:0000176
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
is described by: ECO:0000254
type: Reaction

metaR H2Otn
is: SBO:0000185
product: MODEL1310110051#
fast: false
name: H2O transport, nuclear
kinetic law: MODEL1310110051#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_e4ec9762_a6ef_4f18_9600_b0a13dfb7640
initial amount: NaN
is: P00374
initial concentration: NaN
is encoded by: hsa:1719
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: DHFR

metaM tre e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: HMDB00975
boundary condition: false
name: Trehalose
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:16551
has only substance units: false
initial concentration: 1.0
is: C01083
constant: false

metaR H2Otp
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
reversible: true
is: SBO:0000185
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r2196
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110051#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_98a9ca9a_8b96_4699_8cd0_d8bc7da855c7
type: Species
has only substance units: false
is: P05091
boundary condition: true
is encoded by: hsa:217
constant: false
name: ALDH2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM ksi pre2 g
type: Species
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: C00130
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 2
is: SBO:0000247
is: CHEBI:58053
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

metaR RE1804C
kinetic law: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1804
reactant: MODEL1310110051#
fast: false
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_ebf29cee_08c7_47b7_ae84_13311fbaf458
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6241
constant: false
boundary condition: true
initial amount: NaN
name: RRM2
is: P31350
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d3af42f2_2f37_4335_96fa_c2d842d3603c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:11212
type: Species
is: O94903
name: PROSC
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaR FAOXC225C204x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaR FAOXC11
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
type: Reaction
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is described by: ECO:0000000

metaM 44mctr r
constant: false
is: HMDB01023
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17813
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false

metaM udpg c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false
initial concentration: 1.0
is: C00029
name: UDPglucose
is: HMDB00286
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58367
boundary condition: false

metaR AG13T13g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_95086297_6e34_4b47_882d_4c506230df1d
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1356
constant: false
type: Species
name: CP
is: P00450

metaR COAtp
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: coenzyme A transport, peroxisomal
reversible: true
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_566fc455_eda4_49db_8c3c_aa12880ab4bf
initial amount: NaN
is encoded by: hsa:6487
has only substance units: false
initial concentration: NaN
name: ST3GAL3
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: Q5T4W8

http://identifiers.org/biomodels.db/MODEL1310110051#_373beeae_05f1_4a58_b338_634de9488b94
name: EARS2
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q5JPH6
is encoded by: hsa:124454
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_8a31c75a_2ff7_4006_a47c_f7bb4343276e
initial amount: NaN
is: P19634
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:6548
name: SLC9A1
is: SBO:0000252

metaR S3TASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110051#
name: N-acetylglucosamine-3-sulfatase, lysosomal
reactant: MODEL1310110051#
type: Reaction
is: SBO:0000176

metaR r0480
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000

metaM dlnlcgcrn m
is: CHEBI:16004
name: dihomo-gamma-linolenyl carnitine
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
is: HMDB01311
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_19ad0342_26c2_4d8f_94ae_f36107ff22e8
is encoded by: hsa:5336
initial amount: NaN
name: PLCG2
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P16885

metaM cmp c
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: CMP
is: C00055
is: CHEBI:60377
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB00095

metaM co2 c
is: HMDB01967
is: CHEBI:3313
name: CO2
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00011
constant: false
notes: FORMULA: CO2 CHARGE: 0
type: Species
boundary condition: false

metaM thym e
is: CHEBI:17821
name: thymine
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
is: SBO:0000247
boundary condition: false
type: Species
constant: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_42a33e27_2bb3_4d04_99ee_f36e7a069b87
constant: false
is: SBO:0000252
initial concentration: NaN
is: P04062
initial amount: NaN
has only substance units: false
name: GBA
is encoded by: hsa:2629
boundary condition: true
type: Species

metaR PCHOLPm hs
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
name: choline phosphatase
is version of: http://identifiers.org/ec-code/3.1.4.4
modifier: MODEL1310110051#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110051#
reversible: false

metaR r2329
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is: SBO:0000185
reversible: true

metaM 3ivcoa c
name: 3-hydroxyisovalerylcoa
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: HMDB06870
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM 2docohexecoa m
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
name: 2,7,10,13,16,19-docosahexenoylcoa
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR RE0577C
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0577
product: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110051#

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM hs deg1 l
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
boundary condition: false
is: HMDB01352
is: CHEBI:17180
initial amount: NaN
name: heparan sulfate, degradation product 1

http://identifiers.org/biomodels.db/MODEL1310110051#_5818b422_ba78_4f7d_81ba_c318b0818cff
is: O60762
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8813
name: DPM1
initial concentration: NaN
type: Species
is: SBO:0000252

metaM ksi pre6 g
is: CHEBI:58053
boundary condition: false
initial amount: NaN
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: HMDB00175
is: C00130
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 6
has only substance units: false
constant: false
type: Species

metaM ala B m
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
is: HMDB00056
is: CHEBI:16958
type: Species
name: beta-alanine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_b4a3b660_303b_4775_b738_e8d937402526
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3291
name: HSD11B2
initial amount: NaN
is: P80365

http://identifiers.org/biomodels.db/MODEL1310110051#_497dfecb_06a4_4057_9178_c6fea771996f
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3099
has only substance units: false
boundary condition: true
name: HK2
initial concentration: NaN
is: P52789

metaM xol7ah c
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: CHEBI:2290
is: SBO:0000247
is: HMDB06892
initial concentration: 1.0
name: 7alpha-hydroxy-5beta-cholestan-3-one
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaM HC01115 c
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:29025
name: NeuNGc
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaM hmgcoa x
initial concentration: 1.0
is: CHEBI:15467
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247

metaR C226COAtx
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
name: fatty acid intracellular transport

metaM o2s m
is: HMDB02168
is: C00704
name: Superoxide anion
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18421

metaR H2Otm
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
fast: false
name: H2O transport, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaM ru5p D c
is: CHEBI:58121
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: D-ribulose 5-phosphate(2-)
is: HMDB00618
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

metaM tym c
is: HMDB00306
initial concentration: 1.0
boundary condition: false
is: CHEBI:327995
name: tyraminium
initial amount: NaN
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaM leuktrE4 c
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB02200
type: Species
name: leukotriene E4(1-)

metaM sbt D e
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
type: Species
name: D-glucitol
initial concentration: 1.0
is: HMDB00247

metaM ahcys m
is: SBO:0000247
type: Species
is: CHEBI:16680
initial concentration: 1.0
is: C00021
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
initial amount: NaN
name: S-Adenosyl-L-homocysteine
boundary condition: false
has only substance units: false
is: HMDB00939

metaR S4TASE2ly
reversible: true
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110051#
modifier: MODEL1310110051#

metaM hspg e
name: heparan sulfate proteoglycan
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: CHEBI:32366
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: HMDB02259

metaM mpdol L c
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
has only substance units: false
is: CHEBI:18396
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_bdad55c0_1d6d_4f8b_9972_e8a6389dcf63
is: SBO:0000252
boundary condition: true
constant: false
is: P17516
has only substance units: false
type: Species
initial amount: NaN
name: AKR1C4
is encoded by: hsa:1109
initial concentration: NaN

metaM cmp e
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:60377
type: Species
is: HMDB00095

metaM co2 e
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
constant: false
is: C00011
type: Species
is: HMDB01967
is: CHEBI:16526

metaM thym c
is: C00178
constant: false
name: Thymine
is: CHEBI:17821
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00262
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178

http://identifiers.org/biomodels.db/MODEL1310110051#_035156cc_5f95_4e8f_b520_6f3128850f9d
has only substance units: false
type: Species
is: SBO:0000252
name: _FLJ44968_1_m
initial amount: NaN
is encoded by: hsa:FLJ44968
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_e839000b_d44b_4bad_9ad8_bfbe373c9662
is encoded by: hsa:341947
is: Q7Z4L0
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: COX8C

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR C161CRN2t
is described by: ECO:0000269
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
name: C161 transport into the mitochondria
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: false
reactant: MODEL1310110051#
is: SBO:0000185

metaR r0268
modifier: MODEL1310110051#
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110051#
is described by: ECO:0000000
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_ac591071_8333_4290_9903_c0438b9e31c9
is: Q9H903
has only substance units: false
initial concentration: NaN
is encoded by: hsa:441024
is: SBO:0000252
name: MTHFD2L
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaM HC01842 c
type: Species
is: CHEBI:31997
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
name: Phosphodimethylethanolamine
initial amount: NaN
boundary condition: false
has only substance units: false

metaR THP2Ctp
reactant: MODEL1310110051#
is: SBO:0000185
reversible: true
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
fast: false

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR r2199
reversible: true
product: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_0720e664_7795_4e08_a7af_1a71bbd47d05
has only substance units: false
is encoded by: hsa:116369
name: SLC26A8
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR ARGtm
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110051#
reversible: true
name: arginine mitochondrial transport via ornithine carrier
kinetic law: MODEL1310110051#
type: Reaction

metaM nadp r
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
initial concentration: 1.0
is: CHEBI:58349
has only substance units: false
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
type: Species
initial amount: NaN
is: C00006

http://identifiers.org/biomodels.db/MODEL1310110051#_706fd9d5_38c5_470d_9cde_76dc2c753fbc
initial concentration: NaN
is: Q8WZ48
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1374
boundary condition: true
name: CPT1A
has only substance units: false
constant: false

metaR 2OXOADOXm
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.61
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB

metaR DECDICRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR PMTCOAtx
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_44bb18cc_38ca_43df_a4b9_1d4e6a4ddd9c
initial amount: NaN
boundary condition: true
is encoded by: hsa:5152
initial concentration: NaN
is: SBO:0000252
name: PDE9A
has only substance units: false
type: Species
constant: false

metaM sbt D c
is: HMDB00247
has only substance units: false
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247
is: CHEBI:17924
name: D-glucitol
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaM leuktrE4 e
name: leukotriene E4(1-)
constant: false
is: CHEBI:57462
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
is: HMDB02200
initial concentration: 1.0
type: Species

metaR FAOXC123C102m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR RETI1
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: retinol isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reactant: MODEL1310110051#
type: Reaction
reversible: true

metaM hs deg15 l
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126
initial amount: NaN
name: heparan sulfate, degradation product 15

metaR r1637
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110051#
reversible: true
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110051#

metaR r2325
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110051#

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM 4izp c
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 4-Imidazolone-5-propanoate
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
boundary condition: false
is: HMDB01014
is: CHEBI:57255
is: SBO:0000247

metaM nrpphrsf e
name: Sulfate derivative of norepinephrine
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/123747
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: SBO:0000247
is: HMDB02062
initial concentration: 1.0
type: Species

metaR FAOXC101C8m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM udpglcur c
initial amount: NaN
name: UDP-D-glucuronate
is: HMDB00935
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
initial concentration: 1.0
has only substance units: false
type: Species
is: C00167
is: SBO:0000247
constant: false
boundary condition: false

metaR r0113
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176

metaM sgalside hs l
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false
initial concentration: 1.0
type: Species
is: HMDB00904
is: CHEBI:16349
is: SBO:0000247
name: sulfatide galactocerebroside

metaM q10 m
is: HMDB01072
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
is: CHEBI:46245
boundary condition: false
has only substance units: false
type: Species
name: ubiquinone-10
initial concentration: 1.0

metaM dec47dicoa x
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
name: 4,7-decadienoylcoa
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d5ebfc76_66c9_4f4d_b90b_fbf458a99183
boundary condition: true
name: HMGCR
is: P04035
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:3156
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f1d9b369_092a_4a2e_958e_8f799d92cd8e
constant: false
is: Q13630
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: TSTA3
is encoded by: hsa:7264
boundary condition: true

metaM cmp g
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
is: HMDB00095
type: Species
name: CMP(2-)
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:60377

http://identifiers.org/biomodels.db/MODEL1310110051#_8bbf1c56_25cf_4098_957f_7e0d61ae9586
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: FBP2
constant: false
is: O00757
is: SBO:0000252
is encoded by: hsa:8789

metaM 3hodcoa c
is: HMDB13336
initial concentration: 1.0
name: (S)-3-Hydroxyoctadecanoyl-CoA
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H66N7O18P3S CHARGE: -4

metaR IVCOAACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR r2326
kinetic law: MODEL1310110051#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110051#

metaR r1636
is: SBO:0000185
product: MODEL1310110051#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
fast: false
type: Reaction

metaR RE3565C
fast: false
name: RE3565
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_3daf43f0_f2b2_41aa_ac95_55cb02aa16e6
has only substance units: false
name: CMAS
constant: false
boundary condition: true
is encoded by: hsa:55907
initial concentration: NaN
initial amount: NaN
is: Q8NFW8
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_126417ad_fd6e_472a_b8c1_520be91891d1
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:217
is: P05091
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: ALDH2

metaM xylt c
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17151
type: Species
initial amount: NaN
name: xylitol
is: HMDB02917
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b6ecc9c9_aceb_487a_85c4_4ab4dca69a06
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: Q02742
is encoded by: hsa:2650
name: GCNT1
boundary condition: true

metaR RE0452M
type: Reaction
reactant: MODEL1310110051#
name: RE0452
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
type: Reaction
fast: false

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM lthstrl r
is: CHEBI:17168
is: SBO:0000247
name: 5alpha-cholest-7-en-3beta-ol
boundary condition: false
is: HMDB01170
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189

metaR r2327
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110051#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110051#

metaM glu5sa c
has only substance units: false
name: L-Glutamate 5-semialdehyde
boundary condition: false
initial concentration: 1.0
is: HMDB02104
is: CHEBI:17232
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: C01165
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_ef0aca32_bd03_4760_80be_92f7ec4b07a9
type: Species
name: _AI345944_1_m
is encoded by: hsa:AI345944
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaR AMANK
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
kinetic law: MODEL1310110051#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.59
reversible: false
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
fast: false
is: SBO:0000176
name: N-acetyl-D-mannosamine kinase
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.1.3.14

metaR r0539
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#

metaM prostge1 e
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:57397
initial concentration: 1.0
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
is: HMDB01442
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_1686ac72_2039_47c4_b063_d4c3d9c8a05f
initial concentration: NaN
is encoded by: hsa:2203
has only substance units: false
name: FBP1
boundary condition: true
constant: false
is: Q2TU34
type: Species
is: SBO:0000252
initial amount: NaN

metaM dtdp c
is: SBO:0000247
is: CHEBI:58369
initial amount: NaN
is: HMDB01274
type: Species
initial concentration: 1.0
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
boundary condition: false
name: dTDP
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_4b615fc5_c6f4_48f4_aeff_f5b53d4ed0cc
boundary condition: true
name: ADH5
is encoded by: hsa:128
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: Q6IRT1
is: SBO:0000252

metaR FAOXC123C102x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaR H2Otg
product: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: H2O transport, Golgi apparatus
kinetic law: MODEL1310110051#

metaR r1638
reversible: true
product: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_3ccac3ca_8ae3_45be_8b29_ee5f5984cd7f
boundary condition: true
is: SBO:0000252
name: PANK2
initial concentration: NaN
is: Q6P1K9
has only substance units: false
is encoded by: hsa:80025
initial amount: NaN
constant: false
type: Species

metaR r2328
reversible: true
product: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185

metaM adp c
is: SBO:0000247
type: Species
name: ADP
is: C00008
is: CHEBI:16761
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3310
is: HMDB01341
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM 3ivcoa m
boundary condition: false
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB06870
constant: false
initial amount: NaN
has only substance units: false
name: 3-hydroxyisovalerylcoa
notes: FORMULA: C26H40N7O18P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110051#_30a534d3_b4c3_45d6_a2f3_3edd17fff938
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: O15382
is: SBO:0000252
has only substance units: false
name: BCAT2
initial amount: NaN
is encoded by: hsa:587

metaM xylt e
initial concentration: 1.0
is: CHEBI:17151
has only substance units: false
initial amount: NaN
is: HMDB02917
type: Species
is: SBO:0000247
name: xylitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_4f58ae6d_ce4b_4c40_813d_3b8977967053
type: Species
name: SLC4A4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8671
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: A5JJ20

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type: Species
initial concentration: NaN
is: SBO:0000252
is: P32320
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:978
name: CDA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_eaaad284_8ffb_4584_a56c_7c58e4379e00
name: ACAT2
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:39
type: Species
is: Q9BWD1
initial amount: NaN

metaR PPNCL3
is: SBO:0000176
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110051#
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.3.2.5
fast: false
modifier: MODEL1310110051#
name: phosphopantothenate-cysteine ligase

metaR S6TASE9ly
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM glcur l
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: HMDB00127
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:15748
has only substance units: false
initial concentration: 1.0

metaM prist c
name: pristanic acid
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:51340
is: HMDB00795
constant: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_0e00ae01_f88a_47d7_9cda_b80771a059b9
name: SLC16A1
type: Species
boundary condition: true
constant: false
has only substance units: false
is: B4DKS0
initial concentration: NaN
is encoded by: hsa:6566
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_68568a0e_abe6_44d0_82f5_bbe51573262a
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O43820
type: Species
is encoded by: hsa:8372
is: SBO:0000252
initial amount: NaN
name: HYAL3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_108626cc_6654_4034_a473_586b059519d8
initial concentration: NaN
initial amount: NaN
constant: false
is: P30837
is: SBO:0000252
is encoded by: hsa:219
has only substance units: false
type: Species
boundary condition: true
name: ALDH1B1

http://identifiers.org/biomodels.db/MODEL1310110051#_9b559cec_1ca8_4b21_8ce3_07605399ab31
has only substance units: false
is encoded by: hsa:5294
boundary condition: true
has part: Q9UBK5
constant: false
initial amount: NaN
is encoded by: hsa:10870
has part: P48736
type: Species
initial concentration: NaN
is: SBO:0000297
name: HCST:PIK3CG

metaM ala B c
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
is: HMDB00056
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16958
initial amount: NaN
has only substance units: false
name: beta-alanine

metaR MDHm
is: SBO:0000176
reversible: true
reactant: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.37
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000134
type: Reaction
name: malate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical

http://identifiers.org/biomodels.db/MODEL1310110051#_e3e77b6c_4d04_4bb1_8e83_985e2c87522f
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
has part: Q8NCI4
constant: false
boundary condition: true
name: PIGF:PIGG
is: SBO:0000297
is encoded by: hsa:54872

metaR r2321
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185

metaR r2088
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
product: MODEL1310110051#
type: Reaction

metaR LINKDEG2ly
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
fast: false
name: degradation of proteoglycan linkage region, lysosomal

metaR FAOXC204C184m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaM dtdp e
is: CHEBI:58369
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
initial concentration: 1.0
is: HMDB01274
type: Species
initial amount: NaN

metaM 4mzym int1 r
is: HMDB06927
name: 4-Methylzymosterol intermediate 1
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_6dee8342_b056_4695_9a91_28894092b4ac
is: SBO:0000252
boundary condition: true
name: PSAT1
is: Q9Y617
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:29968
initial concentration: NaN
has only substance units: false

metaR TTDCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
is described by: ECO:0000269
reversible: false
name: carnitine O-palmitoyltransferase
product: MODEL1310110051#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_62b6fe11_adf3_43dd_b45f_fd159bec0069
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:11046
initial concentration: NaN
is: Q76EJ3
constant: false
name: SLC35D2
is: SBO:0000252

metaM gtp c
has only substance units: false
name: GTP
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:37565
is: C00044
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
is: HMDB01273

metaM CE5116 x
has only substance units: false
is: CHEBI:57923
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_e838c546_5190_4344_86f8_7e08f08016f9
initial concentration: NaN
type: Species
has only substance units: false
is: P16066
boundary condition: true
is encoded by: hsa:4881
name: NPR1
constant: false
initial amount: NaN
is: SBO:0000252

metaR r2089
reversible: true
product: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM formcoa x
is: CHEBI:57376
boundary condition: false
is: SBO:0000247
is: HMDB03419
name: formyl-CoA(4-)
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
type: Species

metaM hspg l
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01993
is: CHEBI:17899
has only substance units: false
boundary condition: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
constant: false
name: heparan sulfate proteoglycan

metaM o2s e
has only substance units: false
name: superoxide
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
boundary condition: false
is: HMDB02168
is: SBO:0000247
type: Species

metaR r2322
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110051#

metaR G14T9g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_1ac97779_5eef_45c9_a58f_064c36808239
name: NT5C3
has only substance units: false
is encoded by: hsa:51251
is: Q9H0P0
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR COAtn
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: coenzyme A transport, nuclear
reversible: true
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_e52fed4c_5bce_473c_8726_7f644d7aee75
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:2982
has only substance units: false
is: D6RDW3
initial concentration: NaN
name: GUCY1A3

http://identifiers.org/biomodels.db/MODEL1310110051#_7df3e7bd_ef60_4d69_9ebc_358315c09403
type: Species
boundary condition: true
has only substance units: false
name: SLC26A7
initial amount: NaN
is encoded by: hsa:115111
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_f26c6c0c_ec9b_4ef4_96ff_39b9413499fc
boundary condition: true
name: SLC26A6
type: Species
constant: false
is encoded by: hsa:65010
has only substance units: false
is: Q548A7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r2323
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110051#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ala B e
name: beta-alanine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
type: Species
is: CHEBI:16958
boundary condition: false

metaM nrpphrsf c
is: HMDB02062
boundary condition: false
name: Sulfate derivative of norepinephrine
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/123747
is: SBO:0000247
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_7c88f6a4_7f59_4c0e_a7e1_c53376bea724
type: Species
name: SUCLG1:SUCLA2
has only substance units: false
initial concentration: NaN
has part: E5KS60
is encoded by: hsa:8803
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110051#_2ab56596_989f_484c_b86c_01c539a28bc3
is encoded by: hsa:377677
is: Q8N1Q1
name: CA13
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM co2 m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: CO2
boundary condition: false
constant: false
type: Species
is: HMDB01967
is: C00011
is: CHEBI:16526
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

metaM cmp m
is: CHEBI:60377
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00095
boundary condition: false
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
name: CMP(2-)
is: SBO:0000247

metaR r2086
modifier: MODEL1310110051#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR TETTET6t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction

metaR HACD9m
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is described by: ECO:0000134
fast: false
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#

metaR COAtm
name: CoA transporter
reversible: true
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#

metaR CYTK4n
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
name: cytidylate kinase (dCMP,GTP),nuclear
is described by: ECO:0000269
type: Reaction

metaM Ser Gly Ala X Gly l
constant: false
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: CHEBI:36005
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB02183
has only substance units: false
is: SBO:0000247

metaR UREAt
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: Urea transport via facilitate diffusion
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
reversible: true
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#

metaR RE1826C
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
reversible: false
is described by: ECO:0000000
name: RE1826
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_ee8d9894_a286_4082_a522_ab2c12ce543a
type: Species
initial amount: NaN
name: SLC25A16
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:8034
is: SBO:0000252
is: P16260
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_018f68f3_f3ca_44f0_95b2_d61f100730b9
initial concentration: NaN
boundary condition: true
is: O15245
constant: false
is encoded by: hsa:6580
has only substance units: false
initial amount: NaN
type: Species
name: SLC22A1
is: SBO:0000252

metaR PPAt
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
kinetic law: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
reversible: false
fast: false
type: Reaction
name: Propionate transport, diffusion

metaR r2324
kinetic law: MODEL1310110051#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#

metaM sgalside hs g
initial concentration: 1.0
boundary condition: false
is: HMDB00061
constant: false
has only substance units: false
name: sulfatide galactocerebroside
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:58343
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1

metaM pmtcrn x
initial concentration: 1.0
is: HMDB00222
has only substance units: false
is: CHEBI:17490
boundary condition: false
constant: false
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
name: L-palmitoylcarnitine
initial amount: NaN

metaR r2087
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaM retinol c
constant: false
has only substance units: false
is: CHEBI:50211
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
is: SBO:0000247
initial concentration: 1.0
name: retinol
is: HMDB00305
initial amount: NaN

metaR C50CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaM o2s c
boundary condition: false
initial amount: NaN
name: superoxide
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:18421
initial concentration: 1.0
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false

metaM lald L c
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:18041
initial amount: NaN
name: (S)-lactaldehyde
is: HMDB03052
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1

metaM udpacgal c
initial concentration: 1.0
has only substance units: false
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN
is: CHEBI:57847
is: SBO:0000247
constant: false
boundary condition: false
type: Species

metaR COAtl
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: CoA transport in lysosome via diffusion
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
fast: false

metaM cmp n
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
is: SBO:0000247
boundary condition: false
name: CMP(2-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:60377
type: Species
is: HMDB00095
constant: false

metaM gthox m
has only substance units: false
is: HMDB03337
type: Species
is: CHEBI:58297
constant: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r2097
modifier: MODEL1310110051#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR SERGLNNaEx
is described by: ECO:0000269
kinetic law: MODEL1310110051#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
product: MODEL1310110051#
modifier: MODEL1310110051#
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110051#
fast: false

metaM hmgcoa c
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15467
has only substance units: false
boundary condition: false
constant: false
is: HMDB01375
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA

metaR DNDPt28m
name: dCDP transport via dGDP antiport
kinetic law: MODEL1310110051#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110051#
is: SBO:0000185
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
is described by: ECO:0000269

metaM fuc1p L c
is: CHEBI:28319
boundary condition: false
is: HMDB01265
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
constant: false
name: L-Fucose 1-phosphate
initial concentration: 1.0
type: Species
initial amount: NaN

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR r1640
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110051#
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_5b9297e0_b8bf_403d_8895_775e01438a17
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ABAT
is encoded by: hsa:18
is: SBO:0000252
type: Species
is: P80404
boundary condition: true
constant: false

metaM 6pgc r
is: SBO:0000247
is: CHEBI:58759
is: HMDB01316
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
has only substance units: false
name: 6-phosphonatooxy-D-gluconate
constant: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR r2096
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM 3hbcoa m
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
constant: false
type: Species
is: HMDB01166
is: CHEBI:57316
is: SBO:0000247
initial concentration: 1.0
name: (S)-3-hydroxybutanoyl-CoA(4-)

metaM pser L c
type: Species
is: SBO:0000247
initial concentration: 1.0
name: O-Phospho-L-serine
has only substance units: false
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: HMDB01721
initial amount: NaN
constant: false
is: CHEBI:15811
boundary condition: false

metaR AHEXASEly
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a570dd34_d410_493d_9f83_e325bfd089d5
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8706
type: Species
initial amount: NaN
is: Q49AT3
name: B3GALNT1

metaR BILIRUBt2
product: MODEL1310110051#
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport

metaR RE3000M
reversible: true
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000
name: RE3000
modifier: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaR r0545
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110051#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR r1641
kinetic law: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR TTDCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
reversible: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is described by: ECO:0000000

metaM udpacgal g
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00304
is: CHEBI:57847
type: Species
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false

metaR r2095
modifier: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f12dd313_b7fb_485a_9b5b_aecd4ef41ffe
is encoded by: hsa:55312
initial concentration: NaN
constant: false
is: B2RDZ2
has only substance units: false
boundary condition: true
name: RFK
type: Species
initial amount: NaN
is: SBO:0000252

metaR S6T14g
product: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM glcur c
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
has only substance units: false
initial amount: NaN
name: D-glucuronate
is: SBO:0000247
is: CHEBI:15748
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00127

metaR r2320
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR NDPK7n
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110051#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_eaa6e730_238a_40f3_9201_31c3f05840de
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: _728637_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:728637

metaR r1642
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
fast: false

metaM xolest2 hs e
boundary condition: false
name: cholesterol ester
initial concentration: 1.0
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:17002
constant: false

metaR AASAD3m
is: SBO:0000176
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
name: L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15865210 NOTES:MM. Found under reaction synonym name: 2-aminoadipic 6-semialdehyde dehydrogenase; Evidence was from mouse with identification of good human ortholog for U26 in the mouse that catalyzes this reaction. There was NOT evidence here specific to mitochondria, though. (Nathan Price)
reactant: MODEL1310110051#

metaM i e
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: SBO:0000247
type: Species
constant: false
name: iodide
has only substance units: false
boundary condition: false
is: HMDB12238
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16382

http://identifiers.org/biomodels.db/MODEL1310110051#_5b4fdce3_720a_4e1a_bd32_d4e14c18ce55
is: Q9Y2C3
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:10317
initial concentration: NaN
name: B3GALT5

http://identifiers.org/biomodels.db/MODEL1310110051#_6b3fd39b_e4e0_42ed_a845_b086005be830
is: P37837
boundary condition: true
is encoded by: hsa:6888
type: Species
constant: false
name: TALDO1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r2094
is: SBO:0000185
reactant: MODEL1310110051#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_964a621c_d62d_4b36_8581_08ff52342611
constant: false
initial amount: NaN
is: SBO:0000252
name: OXSM
is: Q9NWU1
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54995
has only substance units: false

metaR CORE6GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reversible: false
fast: false

metaR NOt
name: NO transport (diffusion)
reactant: MODEL1310110051#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is: SBO:0000185
kinetic law: MODEL1310110051#
fast: false

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR HEDCECRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaR r1643
type: Reaction
fast: false
reactant: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000

metaR DOLP Lter
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
name: dolichol phosphate flippase (liver)
is: SBO:0000176
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110051#
fast: false
reversible: false

metaM dttp m
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
has only substance units: false
is: CHEBI:37568
boundary condition: false
is: HMDB01342
initial amount: NaN
initial concentration: 1.0
is: C00459
type: Species
name: dTTP

metaR r2093
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
is described by: ECO:0000000
fast: false

metaR ENGASE2ly
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110051#_efd31146_4686_4476_b95e_835a276155db
is: SBO:0000252
initial amount: NaN
is: Q4KWH8
has only substance units: false
constant: false
is encoded by: hsa:23007
initial concentration: NaN
boundary condition: true
name: PLCH1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_7f929fee_c3fd_447d_8242_229a93f8a49f
is: SBO:0000252
boundary condition: true
name: G6PC3
initial amount: NaN
is encoded by: hsa:92579
initial concentration: NaN
type: Species
is: Q9BUM1
has only substance units: false
constant: false

metaR r1644
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_71f8e470_fe28_4984_aa38_c6afae809010
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6487
boundary condition: true
name: ST3GAL3
constant: false

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaM glcur e
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
has only substance units: false
name: D-glucuronate
constant: false
is: SBO:0000247
is: HMDB00127
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_ea75e1ee_6b6f_4cc4_9a4d_47667c367c52
is: SBO:0000252
boundary condition: true
is: Q546Y9
is encoded by: hsa:57379
name: AICDA
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaM ctdecdcoa m
name: cis2trans4decadienoylcoa
type: Species
has only substance units: false
is: HMDB00792
initial amount: NaN
is: C08277
constant: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247

metaM co2 r
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: CO2
is: HMDB01967
is: C00011
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16526
constant: false
type: Species
has only substance units: false
boundary condition: false

metaM ksi pre10 g
is: CHEBI:58053
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00175
is: C00130
boundary condition: false
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
constant: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 10
is: SBO:0000247

metaM dcsptn1 c
boundary condition: false
is: HMDB13123
name: docosa-4,7,10,13,16-pentaenoic acid
has only substance units: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5282848

http://identifiers.org/biomodels.db/MODEL1310110051#_a794a884_ea40_4d71_af30_38f3f61e2008
boundary condition: true
type: Species
has part: P16278
has part: P10619
initial amount: NaN
has only substance units: false
has part: Q99519
is encoded by: hsa:2720
is encoded by: hsa:4758
is encoded by: hsa:5476
is encoded by: hsa:2588
constant: false
initial concentration: NaN
name: GALNS:GLB1:NEU1:CTSA
is: SBO:0000297
has part: P34059

http://identifiers.org/biomodels.db/MODEL1310110051#_35fdf152_4723_4bb7_b28d_4697e9e4b50b
is: O00400
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9197
type: Species
name: SLC33A1

http://identifiers.org/biomodels.db/MODEL1310110051#_b548a523_b185_4031_ab7b_e162d583f84b
is: SBO:0000252
is encoded by: hsa:5315
is: B4DNK4
initial concentration: NaN
type: Species
constant: false
name: PKM2
has only substance units: false
initial amount: NaN
boundary condition: true

metaM dttp n
is: HMDB01342
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
is: C00459
name: dTTP
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:37568
boundary condition: false

metaR COAtg
is described by: ECO:0000000
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110051#
type: Reaction
name: CoA transport in Golgi via diffusion
is: SBO:0000185
reversible: true
product: MODEL1310110051#

metaR r2092
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM gly m
has only substance units: false
is: SBO:0000247
name: Glycine
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0
is: CHEBI:15428
is: C00037
constant: false
is: HMDB00123
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_bfe1f756_c0e1_47e3_b8b2_17d46d69a85a
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5092
constant: false
name: PCBD1

http://identifiers.org/biomodels.db/MODEL1310110051#_44cfc9f3_dc56_4985_a138_236e2895cabf
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:4723
initial concentration: NaN
name: NDUFV1
initial amount: NaN
is: E5KNH5

http://identifiers.org/biomodels.db/MODEL1310110051#_7b7112f3_6a2b_4d27_854e_fb2af0459019
name: NT5C1B
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q96P26
type: Species
is encoded by: hsa:93034

metaR RDH3a
is: SBO:0000176
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction
modifier: MODEL1310110051#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.300
name: retinol dehydrogenase (11-cis,NADPH)
product: MODEL1310110051#

metaM cmpacna c
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57812

metaM gdpmann c
is: HMDB01163
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: GDP-alpha-D-mannose(2-)
type: Species
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: CHEBI:57527
initial amount: NaN
initial concentration: 1.0

metaR r1645
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_84359b30_c8fe_4902_9732_9d82cbcc1b64
has part: P18545
initial amount: NaN
is encoded by: hsa:5148
has part: O43924
is: SBO:0000297
boundary condition: true
constant: false
is encoded by: hsa:5147
has only substance units: false
type: Species
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_f302e317_aa96_427d_8193_512c507f1acb
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3157
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: HMGCS1
is: Q01581

metaM 3dsphgn c
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
is: HMDB01480
is: CHEBI:58299
constant: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR r0755
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
reversible: true
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
modifier: MODEL1310110051#
is: SBO:0000176

metaR r0541
modifier: MODEL1310110051#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110051#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
type: Reaction
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r1859
product: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110051#
type: Reaction

metaM HC02206 c
boundary condition: false
type: Species
is: CHEBI:57399
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: prostaglandin C1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0

metaM 3odcoa x
is: HMDB03939
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
type: Species
constant: false
initial amount: NaN
is: CHEBI:28528
name: 3-Oxodecanoyl-CoA

metaM acngalgbside hs g
is: SBO:0000247
initial amount: NaN
is: HMDB03406
name: sialyl galactosylgloboside
is: CHEBI:16523
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

metaM ksi deg24 l
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
is: HMDB00143
is: CHEBI:12936
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 24
initial amount: NaN
is: SBO:0000247

metaM HC01223 m
initial concentration: 1.0
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false
is: CHEBI:57340
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110051#_dafbf01e_f9d8_4508_acb6_319d5a665d4b
initial amount: NaN
constant: false
is encoded by: hsa:1633
is: SBO:0000252
is: P27707
name: DCK
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR RE0453M
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reactant: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110051#
modifier: MODEL1310110051#
name: RE0453
reversible: true
type: Reaction

metaR FAOXC150m
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR FMNAT
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
kinetic law: MODEL1310110051#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
name: FMN adenylyltransferase

http://identifiers.org/biomodels.db/MODEL1310110051#_c6b4f0f7_46ad_48ee_8273_d2de85ca6d9e
initial amount: NaN
constant: false
is encoded by: hsa:50484
name: RRM2B
type: Species
has only substance units: false
boundary condition: true
is: Q7LG56
is: SBO:0000252
initial concentration: NaN

metaM HC01459 x
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
has only substance units: false
type: Species
boundary condition: false
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
is: CHEBI:27458
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_34006db3_00a6_41fe_b0f7_b218149bc59b
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is: Q9NUB1
name: ACSS1
constant: false
is encoded by: hsa:84532
has only substance units: false
initial concentration: NaN

metaM udpacgal l
has only substance units: false
initial concentration: 1.0
is: HMDB00304
initial amount: NaN
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
is: SBO:0000247
type: Species

metaR r1646
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110051#_472963ed_c0c7_4bba_aeaa_6c44bd407fc2
initial concentration: NaN
type: Species
has only substance units: false
name: NT5C1B
initial amount: NaN
is: SBO:0000252
is: Q96P26
constant: false
boundary condition: true
is encoded by: hsa:93034

http://identifiers.org/biomodels.db/MODEL1310110051#_953f6fd5_a137_46e2_841b_649275bd98e8
initial amount: NaN
name: FTCD
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:10841
is: SBO:0000252

metaM dcsptn1 e
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoic acid
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
is: http://identifiers.org/pubchem.compound/5282848
initial concentration: 1.0
is: HMDB13123

metaM accoa c
is: HMDB01206
has only substance units: false
name: Acetyl-CoA
initial concentration: 1.0
constant: false
type: Species
is: C00024
is: CHEBI:57288
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
is: SBO:0000247

metaR r0754
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110051#_0a07e29b_28ad_4c62_a04e_d8bc67d9d3c9
name: ALG1
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:56052
is: Q9BT22
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_2ff518f1_89af_45e9_83d6_9c7525454f75
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:1798
name: DPAGT1
type: Species

metaM crtsl r
constant: false
name: cortisol
boundary condition: false
is: CHEBI:17650
initial amount: NaN
is: HMDB00063
has only substance units: false
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR FAOXC15NADx
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nad)x
type: Reaction

metaM gcald c
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: glycolaldehyde
constant: false
is: CHEBI:17071
has only substance units: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: HMDB03344
is: SBO:0000247

metaM xol7ah3 c
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:28540
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: SBO:0000247
constant: false
is: HMDB12455
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
initial concentration: 1.0

metaR DURAD
name: dihydrouracil dehydrogenase (NADP)
is: SBO:0000176
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000269
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.1.2

http://identifiers.org/biomodels.db/MODEL1310110051#_5a20a435_84db_4cd8_ad89_a561e0f477a3
type: Species
is encoded by: hsa:286297
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _286297_1_c
constant: false
is: SBO:0000252
initial amount: NaN

metaR r2090
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_a9bb8529_2649_4819_806c_977591adb262
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9UJ70
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:55577
name: NAGK
has only substance units: false

metaR EX doco13ac
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaM nadp c
type: Species
boundary condition: false
is: CHEBI:58349
is: C00006
constant: false
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
initial concentration: 1.0
is: HMDB00217

metaM HC01401 x
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:27668
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_bfb27e06_b0b6_4573_8186_dc15472abc60
initial concentration: NaN
is: A5PKZ1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:11227
name: GALNT5
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM HC02206 e
type: Species
constant: false
boundary condition: false
is: CHEBI:57399
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
has only substance units: false
name: prostaglandin C1(1-)
initial concentration: 1.0

metaR r1647
product: MODEL1310110051#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_63a08f8c_1ee4_4959_9dc1_e6e5e9e5f2b9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6342
is: SBO:0000252
name: SCP2
is: C9JC79
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR r0753
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110051#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
modifier: MODEL1310110051#

metaR THYMDt1
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:9693094 NOTES:TDV
type: Reaction
fast: false
is described by: ECO:0000269
name: thymd transport
is: SBO:0000185
reversible: false
modifier: MODEL1310110051#

metaR FAOXC226205x
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_324fe7f6_eed6_4865_b61a_d47c813b8297
type: Species
is: P30566
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:158
boundary condition: true
name: ADSL

http://identifiers.org/biomodels.db/MODEL1310110051#_67b4597c_f9bf_496f_b27f_fe43ebf2f014
name: PIK3CD:PIK3R1
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has part: E7EX19
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5295
has only substance units: false

metaM HC01401 m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

metaR FAOXC161C161OHm
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR FAOXC163Gm
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM formcoa c
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
is: SBO:0000247
is: CHEBI:57376
is: HMDB03419
boundary condition: false
name: formyl-CoA(4-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_afcf997a_514d_4f86_a232_1d41ea3473f1
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AI656480
initial amount: NaN
initial concentration: NaN
name: _AI656480_1_m
has only substance units: false

metaM retinol 9 cis c
constant: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: HMDB06217
name: 9-cis-retinol
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:17336
type: Species
has only substance units: false

metaM hexdicoa c
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02014
name: hexadecanedioylcoa
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_1c835224_2072_410b_b19b_96dfc000d40f
name: _AA526438_1_m
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA526438
initial concentration: NaN
constant: false

metaM docohexcoa x
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
type: Species
name: 2,4,7,10,13,16-docosahexenoylcoa
has only substance units: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/24892790

metaR C14OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR r0339
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is: SBO:0000176
kinetic law: MODEL1310110051#

metaR r0698
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.27
kinetic law: MODEL1310110051#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
product: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110051#
reversible: true

metaM cbasp e
boundary condition: false
is: C00438
is: CHEBI:32814
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial concentration: 1.0
is: HMDB00828
has only substance units: false
initial amount: NaN
name: N-Carbamoyl-L-aspartate
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_fe7a0c4b_7ce1_416d_9b36_7d93a3df3bc3
type: Species
initial concentration: NaN
name: PANK2
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80025
constant: false

metaM dheas c
initial amount: NaN
type: Species
constant: false
has only substance units: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: SBO:0000247
is: CHEBI:57905
boundary condition: false
is: HMDB01032
initial concentration: 1.0
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)

metaM sucr e
is: C00089
is: CHEBI:17992
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00258
initial amount: NaN
type: Species
has only substance units: false
name: Sucrose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089

metaM hmgcoa m
initial concentration: 1.0
type: Species
is: CHEBI:15467
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR ILETAm
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110051#
reactant: MODEL1310110051#
name: isoleucine transaminase, mitochondrial
fast: false
kinetic law: MODEL1310110051#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110051#

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
name: beta-galactosidase, lysosomal
type: Reaction
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110051#_c4a0e7ad_3f9d_4b7c_b31f_387fe6c30539
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:223
has only substance units: false
is: P49189
constant: false
boundary condition: true
initial amount: NaN
name: ALDH9A1

metaR ARACHCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: fatty acid intracellular transport
is: SBO:0000185
reactant: MODEL1310110051#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_859a0a4d_767c_4544_9dd2_16721ada8a85
is: O00483
type: Species
boundary condition: true
name: NDUFA4
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4697
initial amount: NaN

metaM co2 x
initial amount: NaN
has only substance units: false
is: CHEBI:16526
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
is: HMDB01967
type: Species
is: SBO:0000247
name: carbon dioxide
boundary condition: false

metaM psylchol e
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/94244
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
name: psillium-glycocholic acid complex
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_90e9a969_7096_4ebb_87db_9d68c19e4b69
type: Species
name: AK4
initial amount: NaN
is: P27144
is encoded by: hsa:205
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaR r0483
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
fast: false
type: Reaction
product: MODEL1310110051#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reversible: true

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR 34DHPHEt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
product: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: 3,4-Dihydroxy-L-phenylalanine transport
reversible: true
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_fa863575_ce2d_43d7_b2f7_e8ec1fb7c433
is: B4DER4
initial concentration: NaN
has only substance units: false
name: PIK3CB
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5291
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_ff0fb805_c000_4c3c_92aa_63a002c1833c
initial concentration: NaN
is encoded by: hsa:1491
is: P32929
type: Species
initial amount: NaN
has only substance units: false
name: CTH
is: SBO:0000252
boundary condition: true
constant: false

metaR TCHOLAte
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
name: bile acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_bd942b2b_61f0_4ac6_9815_8009f20ffc14
is encoded by: hsa:3417
initial amount: NaN
is: O75874
boundary condition: true
has only substance units: false
type: Species
name: IDH1
initial concentration: NaN
is: SBO:0000252
constant: false

metaM gacpail hs c
is: CHEBI:57955
name: glucosaminyl-acylphosphatidylinositol
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01127
initial concentration: 1.0
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: C01236
type: Species

metaR ASNALANaEx
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
reversible: false
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_f7498843_6a10_4fcd_b19e_93f8f1508ae1
name: DPM2
is: O94777
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8818
constant: false
boundary condition: true
has only substance units: false

metaM gly x
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
has only substance units: false
constant: false
initial concentration: 1.0
name: glycine
is: HMDB00123
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM hLkynr c
initial concentration: 1.0
has only substance units: false
type: Species
name: 3-hydroxy-L-kynurenine
constant: false
is: HMDB11631
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: CHEBI:17380
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c99a1116_06b5_49f2_a6d5_1caff9f9da9b
has only substance units: false
name: CLYBL
boundary condition: true
is encoded by: hsa:171425
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: Q8N0X4
is: SBO:0000252

metaM 3odcoa m
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:28528
initial concentration: 1.0
boundary condition: false
name: 3-Oxodecanoyl-CoA
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial amount: NaN
is: HMDB03939

metaR r0999
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110051#
name: Facilitated diffusion
product: MODEL1310110051#

metaM adrncoa x
name: adrenyl coenzyme A
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
is: C16170
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
constant: false
boundary condition: false
is: SBO:0000247

metaM dlnlcgcrn c
name: dihomo-gamma-linolenyl carnitine
is: CHEBI:16004
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01311
type: Species
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM eicostetcrn c
has only substance units: false
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
is: SBO:0000247
is: CHEBI:57312
is: HMDB01356
boundary condition: false
initial concentration: 1.0
name: Eicosatetranoyl carnitine
initial amount: NaN
type: Species

metaR RE0453C
name: RE0453
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_8ab8e3bb_66ee_462d_b2d6_0f2647fba446
initial concentration: NaN
name: IDH3G
is encoded by: hsa:3421
initial amount: NaN
is: SBO:0000252
is: P51553
boundary condition: true
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_7f7c7e33_9f62_4d18_944c_affd0cd596f8
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4718
is: Q549M5
boundary condition: true
type: Species
name: NDUFC2
initial concentration: NaN

metaR 5THFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
name: 5-glutamyl-THF transport,m mitochondrial
product: MODEL1310110051#
reversible: false
type: Reaction
is: SBO:0000185

metaR r0998
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion

metaM dd5ecoa m
is: HMDB13028
is: SBO:0000247
name: 5-dodecenoylcoa
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: C01942
initial concentration: 1.0

metaR HGNTOR
is: SBO:0000176
reactant: MODEL1310110051#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.13.11.5
type: Reaction
reversible: false
modifier: MODEL1310110051#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:

metaM glyclt c
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00115
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:29805
is: SBO:0000247
name: glycolate

metaR G6PPer
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
name: glucose-6-phosphate phosphatase, edoplasmic reticular
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.9
type: Reaction

metaM octdececrn c
initial amount: NaN
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB06351
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0

metaR DUTPDPn
type: Reaction
is described by: ECO:0000269
name: dUTP diphosphatase, nuclear
is version of: http://identifiers.org/ec-code/3.6.1.23
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reversible: false
is: SBO:0000176

metaR HOCDACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_2cbbb33f_a721_4db2_999d_0779eee3949a
name: HADHB
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3032
is: P55084
constant: false
type: Species
boundary condition: true
is: SBO:0000252

metaM HC00682 m
constant: false
initial amount: NaN
is: CHEBI:16807
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C10H19NO2S2 CHARGE: 0 INCHI: InChI=1S/C10H19NO2S2/c1-8(12)15-9(6-7-14)4-2-3-5-10(11)13/h9,14H,2-7H2,1H3,(H2,11,13) EHMN_ABBREVIATION: C01136
name: S-Acetyldihydrolipoamide
is: SBO:0000247

metaM sphmyln hs g
is: CHEBI:58216
is: SBO:0000247
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
name: sphingomyelin betaine
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR r0488
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
product: MODEL1310110051#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_b559ed24_bc1d_4249_87ec_6a9a07d74d42
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1351
initial amount: NaN
is: Q53XN1
has only substance units: false
name: COX8A
type: Species
constant: false
initial concentration: NaN

metaR PI5P3K
kinetic law: MODEL1310110051#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.137
modifier: MODEL1310110051#
name: phosphatidylinositol-5-phosphate 3-kinase
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176

metaR ILEt4
reversible: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
modifier: MODEL1310110051#
is described by: ECO:0000304
is: SBO:0000185
name: L-isoleucine transport in via sodium symport
product: MODEL1310110051#
fast: false
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR GLCAASE8ly
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#

metaM nadp m
name: Nicotinamide adenine dinucleotide phosphate
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
constant: false
initial amount: NaN
is: HMDB00217
is: C00006
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_03a5cb60_4637_47e7_958e_7e04e0d97870
boundary condition: true
is: O60658
is encoded by: hsa:5151
has only substance units: false
is: SBO:0000252
type: Species
name: PDE8A
initial concentration: NaN
initial amount: NaN
constant: false

metaR M4MPDOL Lter
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
fast: false
name: m4mpdol flippase

metaM ahcys c
is: SBO:0000247
has only substance units: false
is: C00021
initial amount: NaN
is: HMDB00939
type: Species
boundary condition: false
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
is: CHEBI:16680

http://identifiers.org/biomodels.db/MODEL1310110051#_9e0da81c_b4da_421e_9425_0b1092990025
is: O75747
name: PIK3C2G
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:5288
has only substance units: false
constant: false
initial concentration: NaN

metaM meoh l
is: CHEBI:17790
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01875
name: methanol
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR PTDCAt
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110051#
is: SBO:0000185
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_f45f6aef_7af4_4c4a_a0c8_503daa7db568
boundary condition: true
is: P23368
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4200
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ME2

metaM tethex3coa c
is: http://identifiers.org/pubchem.compound/47205478
type: Species
has only substance units: false
name: tetracosahexaenoyl coenzyme A
is: HMDB06243
constant: false
boundary condition: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C16168

metaR C141ACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_d2abdcc2_16f5_42fa_8237_a3ccc58f6090
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:151531
is: O95045
is: SBO:0000252
constant: false
name: UPP2
boundary condition: true
type: Species

metaR LEUKTRE4t
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: leukotriene E4 transport
type: Reaction
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110051#

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR DMNONCRNt
reactant: MODEL1310110051#
product: MODEL1310110051#
reversible: true
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000

metaR MANtly
product: MODEL1310110051#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110051#
reversible: false
name: mannose efflux from lysosome
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_5a2f303b_9f4b_42e9_8218_856b86be7edb
boundary condition: true
is encoded by: hsa:4830
has only substance units: false
is: SBO:0000297
type: Species
constant: false
name: NME1:NME2
initial concentration: NaN
initial amount: NaN

metaR UDPDOLPT L
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.117
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
reversible: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
is: SBO:0000176
fast: false
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_30f35af5_dade_4274_a8db_49b563b5d3f0
is encoded by: hsa:7001
boundary condition: true
name: PRDX2
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_27415ceb_ec14_4154_b8d1_de58b41a2ce4
is encoded by: hsa:6817
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SULT1A1
type: Species

metaR CLHCO3tex2
reactant: MODEL1310110051#
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
name: chloride transport via bicarbonate countertransport (2:1)
product: MODEL1310110051#
fast: false

metaM cbasp c
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: C00438
type: Species
is: CHEBI:32814
is: HMDB00828
has only substance units: false
name: N-Carbamoyl-L-aspartate
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaM glyphe e
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97415
constant: false
name: Glycylphenylalanine
type: Species
notes: FORMULA: C11H14N2O3 CHARGE: 0
has only substance units: false
initial concentration: 1.0

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR FUCASE2e
modifier: MODEL1310110051#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, extracellular
reversible: false
product: MODEL1310110051#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_e6195c4d_94ab_4628_bf0c_6aed03207dbb
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: O60331
has only substance units: false
initial amount: NaN
name: PIP5K1C
is: SBO:0000252
is encoded by: hsa:23396

metaM dheas e
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
initial concentration: 1.0
type: Species
constant: false
is: HMDB01032
has only substance units: false
is: SBO:0000247
is: CHEBI:57905
initial amount: NaN
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555

metaR P450SCC1m
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
name: cholesterol monooxygenase
is: SBO:0000176
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
reactant: MODEL1310110051#
fast: false

metaR ACHtn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110051#

metaM ahcys e
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: C00021
is: HMDB00939
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: S-Adenosyl-L-homocysteine
constant: false
is: CHEBI:16680
is: SBO:0000247
initial amount: NaN

metaR 5THFtl
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
name: 5-glutamyl-THF transport, lysosomal
type: Reaction

metaR RNDR4
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
type: Reaction
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (UDP)

metaR ASNSERNaEx
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
modifier: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d656d7bc_8da0_4eec_ab6b_a797950e2d7c
name: TXNRD2
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:10587
initial concentration: NaN
type: Species
is: Q9NNW7
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_1779d300_4724_4f0c_bb38_8732df116dcb
is: P11169
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: SLC2A3
constant: false
is: SBO:0000252
is encoded by: hsa:6515

metaM paps g
is: HMDB01134
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: CHEBI:58339
boundary condition: false
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_ac936b03_8231_4c50_a4a9_0cdbea705ce1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8704
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: B4GALT2

metaR FAOXC24C22x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

metaR DNDPt17m
is described by: ECO:0000269
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
name: dUDP transport via dCDP antiport
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_0c1e5938_9445_497c_b9de_d12e98a544a3
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:8527
initial amount: NaN
name: DGKD
type: Species
is: SBO:0000252
boundary condition: true

metaR ALAR
is: SBO:0000176
reversible: true
modifier: MODEL1310110051#
name: alanine racemase
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
fast: false
product: MODEL1310110051#
is described by: ECO:0000212
type: Reaction

metaR ADEt
is described by: ECO:0000269
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
reversible: true
fast: false
name: adenine reversible transport, cytosol
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
kinetic law: MODEL1310110051#

metaM glu L m
is: SBO:0000247
has only substance units: false
is: CHEBI:29985
name: L-glutamate(1-)
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
constant: false
is: HMDB00148
initial concentration: 1.0
initial amount: NaN

metaR FAS180COA
modifier: MODEL1310110051#
name: fatty-acyl-CoA synthase (n-C18:0CoA)
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
type: Reaction

metaR O2St
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
name: superoxide anion transport via diffusion (extracellular)
is: SBO:0000185
reactant: MODEL1310110051#

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_7c5f96ca_fc1e_4834_a037_d70b93c0d186
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:219
name: ALDH1B1
is: P30837
has only substance units: false
boundary condition: true
constant: false

metaM pmtcrn c
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
is: CHEBI:17490
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00222
initial concentration: 1.0
has only substance units: false
name: L-palmitoylcarnitine

metaR G12MT1 L
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
is: SBO:0000176
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_84e1d99a_36ff_410e_99f2_4cd18d761265
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:56606
constant: false
type: Species
is: Q9NRM0
name: SLC2A9
initial concentration: NaN

MODEL1310110051
reaction: metaR r1886
reaction: metaR MM6bg
species: metaM prostgh2 c
reaction: metaR r1613
reaction: metaR SARCStex
reaction: metaR C204CPT1
reaction: metaR r1634
reaction: metaR 3MOX4HOXPGALDOX NADP
reaction: metaR S6T10g
species: metaM tetpent6 c
reaction: metaR RE1533M
reaction: metaR RE0453C
reaction: metaR HSD3B7P
species: metaM dhap e
species: metaM 3ivcoa m
species: metaM ha e
reaction: metaR r1106
reaction: metaR EX malthp LPAREN e RPAREN
species: metaM eicostetcoa m
species: metaM CE2838 e
reaction: metaR EX pi LPAREN e RPAREN
reaction: metaR r1434
reaction: metaR r2526
reaction: metaR DCK2n
reaction: metaR DOLPMT2 Ler
reaction: metaR NDPK3m
species: metaM 2mbcoa m
reaction: metaR MI14PP
species: metaM tmndnccoa c
reaction: metaR EX thf LPAREN e RPAREN
species: metaM 3octdece1crn c
species: metaM chol r
species: metaM mescon m
species: metaM man g
reaction: metaR DNDPt17m
reaction: metaR HPYRRy
reaction: metaR DHEASULT
reaction: metaR r2090
reaction: metaR DM 4abut LPAREN n RPAREN
reaction: metaR FAOXC183C163Gm
reaction: metaR AG13T6g
species: metaM clpn hs c
reaction: metaR CATp
reaction: metaR PRPPS
reaction: metaR S4TASE5ly
reaction: metaR CHOLt4
species: metaM thbpt4acam n
species: metaM creat c
species: metaM c51crn c
reaction: metaR r0186
reaction: metaR r1444
reaction: metaR SO4tl
reaction: metaR r0934
species: metaM xoltetrol c
reaction: metaR ARACHCPT1
reaction: metaR FAOXC16080x
species: metaM leuktrD4 e
species: metaM chlstol r
reaction: metaR r0139
reaction: metaR C81CRNe
species: metaM pep c
reaction: metaR M1316Mg
reaction: metaR DURItn
reaction: metaR EX co LPAREN e RPAREN
species: metaM HC02205 e
reaction: metaR r1597
species: metaM tetdec2crn c
species: metaM lnlncg c
reaction: metaR S6TASE14ly
reaction: metaR FAOXC101C8m
species: metaM cspg e l
species: metaM tethex3coa c
species: metaM CE1926 e
species: metaM dpcoa e
species: metaM lnlncgcoa x
species: metaM etfrd m
reaction: metaR HISCAT1
reaction: metaR GALASE19ly
reaction: metaR r0781
reaction: metaR GRTTx

http://identifiers.org/biomodels.db/MODEL1310110051#_81fd8d68_d1ae_4c3a_a548_c349e89db719
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:114799
name: ESCO1
initial amount: NaN
has only substance units: false
type: Species
is: Q5FWF5
initial concentration: NaN

metaR COt
fast: false
kinetic law: MODEL1310110051#
type: Reaction
name: CO transporter via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is: SBO:0000185
reversible: true
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_3e570d0c_7f0d_4a0c_b73a_78c35aeff646
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q6NSB3
boundary condition: true
constant: false
has only substance units: false
name: AMY1A
is encoded by: hsa:276

metaR RE3273C
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
fast: false
name: RE3273
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.4.4

http://identifiers.org/biomodels.db/MODEL1310110051#_2e036cc9_2e62_4b11_b8d0_9b9da80797ab
is: P14618
constant: false
is encoded by: hsa:5315
type: Species
boundary condition: true
name: PKM2
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_8de35414_79f2_4fd4_8e8e_7a34dd8ea75a
name: INPP5D
constant: false
initial amount: NaN
is encoded by: hsa:3635
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: Q92835

metaR LNLNCACPT1
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110051#
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110051#
reversible: false

metaR GPIMTer U
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
product: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
type: Reaction
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
reversible: false

metaM glyphe c
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H14N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97415
name: Glycylphenylalanine

http://identifiers.org/biomodels.db/MODEL1310110051#_42dbf0d1_ce7e_441d_9715_2c54934343c9
has only substance units: false
boundary condition: true
type: Species
is: Q13946
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5150
initial amount: NaN
constant: false
name: PDE7A

http://identifiers.org/biomodels.db/MODEL1310110051#_84c95443_79d3_46e2_b772_48005f7e795d
is: Q9BVK2
type: Species
boundary condition: true
name: ALG8
constant: false
is encoded by: hsa:79053
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_266d0547_d9cd_47b4_b8aa_1edf1043a167
is encoded by: hsa:60490
name: PPCDC
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: Q96CD2
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR RE1448N
reactant: MODEL1310110051#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
fast: false
name: RE1448
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_edb2648c_61c0_4f31_838d_bbb008b09c40
boundary condition: true
has only substance units: false
name: NME1
constant: false
is: SBO:0000252
is encoded by: hsa:4830
initial concentration: NaN
is: P15531
type: Species
initial amount: NaN

metaR FAOXC102C101x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaM 3hmbcoa m
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
initial concentration: 1.0
boundary condition: false
is: CHEBI:57312
constant: false
type: Species
is: HMDB01356
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a669df17_5575_4667_a68c_005c61305b56
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5136
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: PDE1A
constant: false
is: Q9Y633

metaR LNLNCACPT2
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
name: carnitine transferase
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_76e49dd9_a709_43fd_8767_8d7d9351cecc
name: DGUOK
initial amount: NaN
constant: false
is: E5KSL6
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1716

http://identifiers.org/biomodels.db/MODEL1310110051#_e80a7e59_b0ef_4c5a_94f1_b009f3d1b572
initial concentration: NaN
type: Species
has part: P48728
is encoded by: hsa:275
boundary condition: true
constant: false
is: SBO:0000297
initial amount: NaN
has part: P23434
name: DLD:GCSH:GLDC:AMT
has only substance units: false
is encoded by: hsa:2653
has part: P23378
is encoded by: hsa:2731

metaR AG13T12g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
modifier: MODEL1310110051#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#

metaM glyb m
is: HMDB00043
constant: false
initial concentration: 1.0
is: SBO:0000247
name: glycine betaine
is: CHEBI:17750
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
boundary condition: false
type: Species
has only substance units: false

metaR ADNtm
product: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000185
name: adenosine facilated transport in mitochondria
modifier: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_0c13d967_25f8_42ae_a654_163b828d9b87
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51179
type: Species
name: HAO2
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_b2f40638_d773_44e1_be9f_3aae64908a13
boundary condition: true
is encoded by: hsa:5150
constant: false
type: Species
name: PDE7A
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM dodecanac c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00623
notes: FORMULA: C12H20O4 CHARGE: -2
name: Dodecanedioic acid
constant: false
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_e0cff363_6068_4971_b84e_4ddd861fa3a5
name: SDHA
boundary condition: true
has only substance units: false
is encoded by: hsa:6389
initial amount: NaN
constant: false
is: P31040
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_8fb265f1_1bb4_4747_8499_9e0d9d815372
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q96L53
constant: false
is encoded by: hsa:6487
has only substance units: false
boundary condition: true
type: Species
name: ST3GAL3

metaR r0317
kinetic law: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000000
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.1.2.10

http://identifiers.org/biomodels.db/MODEL1310110051#_af9d2095_d2d2_4f99_87d7_320cf87b2f0e
constant: false
initial amount: NaN
is encoded by: hsa:25902
is: B2RD24
is: SBO:0000252
type: Species
name: MTHFD1L
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_e8e2d575_4035_4ccf_887f_1cffba5f48b1
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:112
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: ADCY6

http://identifiers.org/biomodels.db/MODEL1310110051#_62de49fa_2332_4ccc_a1bf_ef9d308ff043
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AF080579_1_c
constant: false
is encoded by: hsa:AF080579
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_5c97fdcd_0922_4bb5_bd42_3892350e0eb5
is: Q9NUB1
constant: false
name: ACSS1
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:84532
initial concentration: NaN
type: Species
initial amount: NaN

metaM meoh e
is: CHEBI:17790
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: methanol
is: HMDB01875
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
initial amount: NaN
type: Species
boundary condition: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_d5a5b2ec_f046_447c_81a6_497da8b153ee
type: Species
constant: false
is encoded by: hsa:222
is: SBO:0000252
boundary condition: true
is: P48448
initial amount: NaN
has only substance units: false
name: ALDH3B2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_bf40aae2_3e31_4406_bbac_870094e443fe
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:22978
type: Species
initial amount: NaN
is: P49902
name: NT5C2

metaR IDOAASE3ly
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
name: alpha-L-iduronidase, lysosomal
is: SBO:0000176
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_cd6c4d2c_ac3b_4482_8118_5148b190ae03
initial concentration: NaN
type: Species
is encoded by: hsa:BC005314
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: _BC005314_1_x
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_20354798_85e0_4c8b_a235_c41b260fb7dc
is: Q8NCL4
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:11226
initial amount: NaN
name: GALNT6
has only substance units: false
initial concentration: NaN

metaM octdececrn m
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
boundary condition: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
initial amount: NaN
is: HMDB06351
type: Species

metaM asn L c
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
has only substance units: false
constant: false
name: L-asparagine
is: HMDB00168
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:17196

metaM zymst r
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: zymosterol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
type: Species
is: CHEBI:18252
is: SBO:0000247
is: HMDB06271
constant: false

metaM trdrd m
is: SBO:0000247
boundary condition: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
type: Species
name: Reduced thioredoxin
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaM 5thf c
initial amount: NaN
notes: FORMULA: C39H45N11O18 CHARGE: -6
boundary condition: false
is: C00440
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: HMDB01396
has only substance units: false
is: CHEBI:3729
name: pentaglutamyl folate (THF)

metaR EX tdcrn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR S4TASE3ly
reactant: MODEL1310110051#
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
reversible: true

metaR FACOAL80i
name: fatty-acid--CoA ligase (octanoate)
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
product: MODEL1310110051#
type: Reaction
is: SBO:0000176

metaR NRVNCt
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_fea1f938_82f9_4202_ae5a_57e1db987507
is: SBO:0000252
is encoded by: hsa:H77542
name: _H77542_1_c
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_68465b3d_85a3_4ce1_b4d6_bc5c3f67735a
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P52824
constant: false
name: DGKQ
initial concentration: NaN
type: Species
is encoded by: hsa:1609
has only substance units: false

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB11123
is: CHEBI:28387
constant: false
type: Species

metaR FAOXC184C163m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaM HC01118 r
boundary condition: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: CHEBI:57310
initial concentration: 1.0
is: SBO:0000247
name: presqualene diphosphate(3-)
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR ACONT
product: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
reactant: MODEL1310110051#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000134
name: aconitase
is version of: http://identifiers.org/ec-code/4.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110051#_89f978b7_86ce_45ee_a564_6deae8022ad8
constant: false
is: O75387
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:8501
name: SLC43A1
initial concentration: NaN

metaM meoh c
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:17790
name: methanol
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: HMDB01875
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_9fa48328_c55c_4bdf_95d2_b712bfd557cb
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:8395
is: O14986
has only substance units: false
name: PIP5K1B

metaM adrncoa m
is: SBO:0000247
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
is: C16170

metaM asn L e
is: HMDB00168
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
is: CHEBI:17196
has only substance units: false
name: L-asparagine

metaM CE2417 m
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false
has only substance units: false
type: Species
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28387

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_1e35df68_1f8d_4a1d_8dd3_f7f091100780
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: P22303
is encoded by: hsa:43
initial amount: NaN
is: SBO:0000252
name: ACHE

metaM HC01522 c
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:28508
initial amount: NaN
name: Gentisate aldehyde
boundary condition: false
type: Species
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_be79ea28_188c_4f55_93c8_13aa27ece6f0
has only substance units: false
is: Q9NS00
type: Species
constant: false
name: C1GALT1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:56913

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR PROSTGD2t
kinetic law: MODEL1310110051#
is described by: ECO:0000269
fast: false
product: MODEL1310110051#
is: SBO:0000185
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true

metaM glu L l
is: CHEBI:29985
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
has only substance units: false
name: L-glutamate(1-)
initial concentration: 1.0
is: HMDB00148
constant: false
type: Species
boundary condition: false

metaM eicostetcrn m
constant: false
initial concentration: 1.0
is: HMDB01356
name: Eicosatetranoyl carnitine
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
is: CHEBI:57312
type: Species
is: SBO:0000247
boundary condition: false

metaM sph1p c
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: CHEBI:57939
has only substance units: false
is: SBO:0000247
is: HMDB01383
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial amount: NaN

metaR CYTD
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is described by: ECO:0000254
name: cytidine deaminase
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_faabf013_1390_4f7f_839f_c5ab03a2d1cd
constant: false
has only substance units: false
is encoded by: hsa:374907
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q7Z7M8
initial amount: NaN
name: B3GNT8

http://identifiers.org/biomodels.db/MODEL1310110051#_90ad8d83_0979_411e_94ec_e0202a8a2f21
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:4668
boundary condition: true
is: P17050
name: NAGA

metaR C141CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaM xol7a r
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB01496
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
initial concentration: 1.0
is: CHEBI:1296
name: 20-hydroxycholesterol

metaR CYTK9
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dCTP)
is: SBO:0000176
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR MMEm
fast: false
is described by: ECO:0000269
reactant: MODEL1310110051#
name: methylmalonyl-CoA epimerase/racemase
product: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.1.99.1
kinetic law: MODEL1310110051#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV

metaM 2dr1p c
is: C00672
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: HMDB01351
is: CHEBI:58576
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: 2-Deoxy-D-ribose 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110051#_6ef355df_b43b_419d_bf1b_530d713b7fbe
boundary condition: true
is: SBO:0000252
constant: false
name: GALNTL2
is encoded by: hsa:117248
type: Species
is: Q8N3T1
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_66945d02_2fb5_4f6b_8770_da89f8a2e755
has only substance units: false
is encoded by: hsa:1737
initial amount: NaN
constant: false
boundary condition: true
is: Q86YI5
initial concentration: NaN
name: DLAT
is: SBO:0000252
type: Species

metaR r1627
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110051#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#

metaM air c
is: SBO:0000247
is: C03373
boundary condition: false
is: HMDB01235
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
initial amount: NaN
is: CHEBI:58592
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
constant: false
type: Species

metaR TRIODTHYt2
type: Reaction
is: SBO:0000185
name: T3 transport via facilitated diffusion
fast: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
reversible: true
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_997448ae_7bb3_492f_b710_75b3a2070467
name: PIGL
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9487
constant: false
is: Q9Y2B2
is: SBO:0000252
has only substance units: false
type: Species

metaM glyb c
name: glycine betaine
is: CHEBI:17750
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_15bc2308_87a7_490f_b243_11b6826c0d7c
is encoded by: hsa:38
initial amount: NaN
initial concentration: NaN
name: ACAT1
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: P24752

metaM sph1p e
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01383
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: CHEBI:57939
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_57a41ce5_b197_4071_8f56_b434070249f3
is encoded by: hsa:490
name: ATP2B1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: P20020
boundary condition: true

metaR BUTt2r
is described by: ECO:0000269
is: SBO:0000185
reversible: true
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
name: Butyrate transport via proton symport, reversible
kinetic law: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_641938a2_081a_49e3_90b9_5818d95ef5ed
constant: false
initial concentration: NaN
type: Species
name: MTR
is encoded by: hsa:4548
boundary condition: true
is: Q99707
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r0774
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
kinetic law: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110051#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
modifier: MODEL1310110051#
type: Reaction
product: MODEL1310110051#

metaR RE3566C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: RE3566
type: Reaction

metaR r2079
modifier: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR r1626
is: SBO:0000185
reversible: true
product: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false

metaR PTE4x
reactant: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
type: Reaction
is: SBO:0000176
name: peroxisomal acyl-CoA thioesterase
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_8298f8ba_14d1_42a2_964e_d70868f6f29c
is: SBO:0000297
is encoded by: hsa:1743
boundary condition: true
has part: P36957
name: DLD:DLST:OGDH:PDHX
has only substance units: false
is encoded by: hsa:8050
constant: false
initial amount: NaN
is encoded by: hsa:4967
is encoded by: hsa:1738
initial concentration: NaN
has part: Q02218
has part: O00330
has part: P09622
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_9027efe4_46c0_4c2b_aa39_738d6aa9ed64
has only substance units: false
is encoded by: hsa:5297
initial amount: NaN
type: Species
is: B4DYG5
initial concentration: NaN
name: PI4KA
boundary condition: true
constant: false
is: SBO:0000252

metaM gthox c
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: C00127
is: HMDB03337
has only substance units: false
boundary condition: false
is: CHEBI:58297
name: Oxidized glutathione
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

http://identifiers.org/biomodels.db/MODEL1310110051#_c9223ca6_b1f1_4454_ab59_6fabc317aaf5
type: Species
boundary condition: true
name: PDE9A
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_7a7f7f91_6200_42d5_8f68_575caa3c4d9d
is: Q549M5
name: NDUFC2
is encoded by: hsa:4718
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r1625
reversible: true
modifier: MODEL1310110051#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110051#

metaM srtn c
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:350546
initial concentration: 1.0
is: SBO:0000247
is: HMDB00259
constant: false
name: serotonin(1+)
type: Species
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

metaM ksi pre21 g
name: keratan sulfate I biosynthesis, precursor 21
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
initial amount: NaN
is: C00130
notes: FORMULA: C177H284N12O145S6X CHARGE: -7

metaM glyb e
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
name: glycine betaine
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:17750
boundary condition: false
initial concentration: 1.0
is: HMDB00043

metaM HC01410 m
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:28706
initial concentration: 1.0
constant: false
has only substance units: false
name: (2E)-Hexenoyl-CoA

metaR CYTK3n
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110051#
name: cytidylate kinase (dCMP,CTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110051#_7434d2d8_b13a_465b_a537_b7ebe69d1079
initial concentration: NaN
type: Species
is encoded by: hsa:5315
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PKM2

metaM gacpail hs r
is: C01236
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01127
is: CHEBI:57955
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
name: glucosaminyl-acylphosphatidylinositol
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_c073baac_c34e_48a9_86a5_3089cc6d71f8
type: Species
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ST3GAL3
is: Q11203
boundary condition: true
constant: false

metaR SCP21cx
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM 5thf e
is: SBO:0000247
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: HMDB06487
name: pentaglutamyl folate (THF)
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR r1624
fast: false
is: SBO:0000185
product: MODEL1310110051#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000

metaR r2338
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reactant: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
product: MODEL1310110051#

metaM ksii core4 pre1 g
has only substance units: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: CHEBI:28067
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 1
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_e4b11836_df97_4375_ac09_da17b2bcd8c7
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2584
is: P51570
initial amount: NaN
constant: false
name: GALK1
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_02f89681_4665_432f_9b9d_427cbb317bae
boundary condition: true
is: P10619
has only substance units: false
type: Species
name: CTSA
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5476
is: SBO:0000252

metaR S4TASE1ly
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000

metaM pyr x
initial concentration: 1.0
is: C00022
is: SBO:0000247
initial amount: NaN
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
type: Species
constant: false
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
boundary condition: false
is: HMDB00243

metaR ORPT
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.2.10
name: orotate phosphoribosyltransferase
kinetic law: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
product: MODEL1310110051#

metaR RE1530C
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
name: RE1530
is: SBO:0000176
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true

metaM n2m2masn g
initial amount: NaN
notes: FORMULA: C50H83N4O35X CHARGE: 0
has only substance units: false
constant: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
is: C11530
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR N2M2NMASNtly
name: n2m2nmasn transport, extracellular to lysosome
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
type: Reaction

metaM adrncoa c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/47205480
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
initial amount: NaN
has only substance units: false
name: adrenyl coenzyme A
constant: false

metaM srtn e
has only substance units: false
is: HMDB00259
constant: false
is: CHEBI:350546
type: Species
name: serotonin(1+)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

metaM 5thf l
initial concentration: 1.0
name: pentaglutamyl folate (THF)
is: CHEBI:3729
type: Species
is: C00440
boundary condition: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
constant: false
is: HMDB01396
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_d9f041f5_c6cc_47b9_a9c2_7447ae67b95a
name: BAAT
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:570
boundary condition: true
constant: false
has only substance units: false
type: Species
is: Q14032
is: SBO:0000252

metaR CYTK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110051#
name: cytidylate kinase (dCMP)

http://identifiers.org/biomodels.db/MODEL1310110051#_bcedb26e_cb1a_43a1_8e67_24f6bc26a288
is: Q9UF12
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:58510
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: PRODH2

metaR r0547
modifier: MODEL1310110051#
is described by: ECO:0000000
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.17.1.4

metaR ACACt2
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reactant: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
reversible: true
is: SBO:0000185
name: acetoacetate transport via proton symport

metaR C10OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_03050aa4_c8d5_4df6_ab89_0651be45adff
name: AGA
is encoded by: hsa:175
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: P20933
boundary condition: true
has only substance units: false

metaR FACOAL244 1
product: MODEL1310110051#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
type: Reaction
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaM ala L m
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16977
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0
is: HMDB00161

metaR NDPK9n
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110051#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_a46d84dc_a2a1_4c61_9093_7081786c0fa5
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6483
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: Q16842
name: ST3GAL2

metaR S6T16g
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110051#

metaR RE3218C
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is described by: ECO:0000000
name: RE3218
kinetic law: MODEL1310110051#
reversible: true
type: Reaction

metaR RE1573M
type: Reaction
name: RE1573
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reactant: MODEL1310110051#
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false

metaR CYTK6
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#

metaR RNDR1
kinetic law: MODEL1310110051#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
reversible: false
name: ribonucleoside-diphosphate reductase (ADP)
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM hepcoa m
is: HMDB12969
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: heptanoylcoa
is: SBO:0000247
constant: false
notes: FORMULA: C28H44N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110051#_2f904ca5_c06e_4efe_b546_0e4cabe384e2
name: MIA3
boundary condition: true
is: Q5JRA6
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:375056
constant: false
initial amount: NaN

metaM tdcrn e
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false
is: HMDB05066
notes: FORMULA: C21H41NO4 CHARGE: 0
name: myristoyl carnitine
is: SBO:0000247
initial amount: NaN

metaR 3DSPHR
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.102
modifier: MODEL1310110051#
name: 3-Dehydrosphinganine reductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110051#
is: SBO:0000176
fast: false

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR DTMPK
name: dTMP kinase
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR r1629
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#

metaR r2333
product: MODEL1310110051#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction

metaR CYTK7
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110051#
fast: false
is: SBO:0000176
name: cytidylate kinase (CMP,UTP)
kinetic law: MODEL1310110051#
reversible: true
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR r1851
type: Reaction
kinetic law: MODEL1310110051#
name: Y+LAT2 Utilized transport
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false

metaR r0549
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is: SBO:0000176
modifier: MODEL1310110051#
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.1.1.17
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.6.99.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.6.5.3

metaM ksi deg25 l
is: HMDB01354
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
name: keratan sulfate I, degradation product 25
type: Species
is: CHEBI:57455
boundary condition: false
initial amount: NaN

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR FAOXC204184m
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110051#

metaM hdd2crn m
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
is: HMDB06317
is: SBO:0000247
initial concentration: 1.0
name: trans-Hexadec-2-enoyl carnitine

metaR CSPG Etly
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
type: Reaction
fast: false
reactant: MODEL1310110051#
name: chondroitin sulfate E transport, extracellular to lysosome
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110051#

metaM i c
has only substance units: false
is: HMDB12238
is: SBO:0000247
is: CHEBI:16382
boundary condition: false
constant: false
name: iodide
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_2c3bba9a_bb71_4378_ac0c_69dbd18c8602
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: HADHA
is: SBO:0000252
is encoded by: hsa:3030
is: E9KL44
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2b91d105_5e9a_4462_8500_97be9f60f4ce
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4124
type: Species
boundary condition: true
initial concentration: NaN
name: MAN2A1
initial amount: NaN
constant: false
is: Q16706

metaR r1628
reversible: true
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR r2334
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110051#

metaR RBTt
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribitol transport via passive diffusion
reactant: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false

metaR CYTK8
reversible: true
modifier: MODEL1310110051#
product: MODEL1310110051#
name: cytidylate kinase (CMP,dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110051#

metaR r1850
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: false
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110051#
is: SBO:0000185
type: Reaction

metaM tetpent3coa c
initial amount: NaN
type: Species
is: C16167
initial concentration: 1.0
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
constant: false
name: tetracosapentaenoyl coenzyme A, n-3
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR VITD3t2
is: SBO:0000185
reversible: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: Vitamin D3 uptake
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
fast: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR RNDR3
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
reversible: false
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (CDP)

metaM dhcholoylcoa x
has only substance units: false
type: Species
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27393
initial concentration: 1.0
is: HMDB06895
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM tdcrn c
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
constant: false
is: HMDB05066
notes: FORMULA: C21H41NO4 CHARGE: 0
name: myristoyl carnitine
is: SBO:0000247
initial amount: NaN

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR r2083
fast: false
modifier: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110051#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_ef144dff_485f_4259_9e33_0c869efd70e7
name: SCD
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6319
initial amount: NaN
has only substance units: false
is: O00767
boundary condition: true
initial concentration: NaN

metaM 3mop m
is: HMDB00491
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110051#_1170cc30_1804_4e00_aeca_b8ff732ea88a
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:160287
is: Q6ZMR3
name: LDHAL6A
constant: false
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_c3258968_89c2_419f_9bff_a1f88cfb41f9
constant: false
type: Species
is encoded by: hsa:4597
boundary condition: true
name: MVD
is: P53602
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR TETDEC2CRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_91c9f6c7_2c55_469c_87b2_4c688a73be60
is encoded by: hsa:2539
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: G6PD
boundary condition: true
has only substance units: false
initial amount: NaN
is: P11413

metaR RE3520E
reversible: true
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: RE3520
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false
is described by: ECO:0000000
modifier: MODEL1310110051#

metaM CE0785 m
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
name: cis,cis-myristo-5,8-dienoyl-CoA
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57795

metaR DCTPtn
is described by: ECO:0000000
reactant: MODEL1310110051#
product: MODEL1310110051#
name: dCTP diffusion in nucleus
reversible: true
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR r1630
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction

metaR DNDPt27m
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
type: Reaction
name: dCDP transport via dTDP antiport
fast: false

metaM dodecanac x
is: HMDB00623
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H20O4 CHARGE: -2
name: Dodecanedioic acid
boundary condition: false
has only substance units: false
constant: false

metaR r0556
reversible: true
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction

metaM retinal cis 9 c
is: HMDB01358
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
initial amount: NaN
type: Species
is: CHEBI:17898
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_01959dc0_7d44_4234_8e57_8713b1cf4bfd
initial amount: NaN
boundary condition: true
constant: false
is: P37059
is encoded by: hsa:3294
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: HSD17B2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_ff5e0b12_a399_4658_b4b8_635ca2a4fbf5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:BG035985
name: _BG035985_1_c
boundary condition: true
constant: false
has only substance units: false

metaR r2332
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1844
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110051#

metaM pmtcrn r
name: L-palmitoylcarnitine
is: SBO:0000247
is: CHEBI:17490
constant: false
type: Species
has only substance units: false
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR r2082
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000000

metaM so4 m
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16189
name: sulfate
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
has only substance units: false
is: HMDB01448

metaM 12ppd R c
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28972
name: (R)-propane-1,2-diol
is: SBO:0000247
has only substance units: false
is: HMDB01881
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ee8825bf_e510_43bf_9daa_4f4b63b7f28b
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P13686
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:54
name: ACP5

metaR r1631
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110051#
is: SBO:0000185

metaR LNLCCRNt
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110051#
is: SBO:0000185
fast: false
reversible: false
name: transport into the mitochondria (carnitine)

metaM so4 l
is: SBO:0000247
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
name: sulfate
is: CHEBI:16189
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r0555
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000176
reversible: false
modifier: MODEL1310110051#
name: acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12108679,PMID:14741190 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_2683ae13_80e2_4b59_b981_7ab37b583c9e
has only substance units: false
initial concentration: NaN
type: Species
name: NDUFA10
boundary condition: true
is: O95299
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:4705

metaR ACNAMPH
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
is: SBO:0000176
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD

metaM 4nph e
constant: false
name: 4-nitrophenolate
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01232
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: CHEBI:57917
initial amount: NaN

metaR r2331
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000185

metaM nadph r
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
is: CHEBI:57783
initial concentration: 1.0
is: HMDB00221
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0be6fb17_f377_4d84_8c4e_097cbb9174ac
name: ADCY8
is: Q4F7X0
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:114
boundary condition: true
is: SBO:0000252

metaR r2085
type: Reaction
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r2330
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110051#
type: Reaction

metaM 4fumacac c
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: 4-fumarylacetoacetate(2-)
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: CHEBI:18034
initial amount: NaN
has only substance units: false
is: HMDB01268

metaR EX estrones LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Estrone 3-sulfate exchange
type: Reaction

metaM glyclt x
has only substance units: false
type: Species
is: HMDB00115
boundary condition: false
initial amount: NaN
name: glycolate
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
constant: false
initial concentration: 1.0
is: CHEBI:29805
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_772273c3_31c0_4472_961a_cf44dca4d9db
type: Species
has only substance units: false
name: _AI291895_1_c
constant: false
initial amount: NaN
is encoded by: hsa:AI291895
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR FAOXC184C163x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR PI34P5K
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
modifier: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68

http://identifiers.org/biomodels.db/MODEL1310110051#_fb8473b5_03ed_4f35_9004_fcac9d1d4278
constant: false
is encoded by: hsa:56953
type: Species
has only substance units: false
is: Q9NPB1
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: NT5M
initial concentration: NaN

metaR r0558
is described by: ECO:0000000
modifier: MODEL1310110051#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
fast: false
reactant: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_6b0aaf55_6108_4514_a4eb_9e7a7398af6e
initial amount: NaN
is: Q8NBL9
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: PIGS
is encoded by: hsa:94005
boundary condition: true

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaM 5thf m
initial amount: NaN
name: pentaglutamyl folate (THF)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00440
type: Species
is: CHEBI:3729
has only substance units: false
is: HMDB01396
notes: FORMULA: C39H45N11O18 CHARGE: -6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_cb47fb06_870a_4d47_9a6a_9ad7a70541b4
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: HK1
is: A8K7J7
is encoded by: hsa:3098
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_fb7a0e5a_7f68_422d_86d8_8c6f77e95df4
is encoded by: hsa:3948
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: LDHC
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR NDPK8n
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
reversible: true
modifier: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000304
type: Reaction

metaR FAOXC140
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110051#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110051#
is described by: ECO:0000269

metaR S6T15g
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.21
fast: false
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110051#_419f0e01_58bb_4a50_84a7_b0c113fcdea7
is: SBO:0000252
is encoded by: hsa:3028
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: Q99714
name: HSD17B10
initial amount: NaN
boundary condition: true

metaR RETH
name: retinyl ester hydrolase
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110051#
reversible: false
product: MODEL1310110051#
is: SBO:0000176

metaR CERT1rt
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
product: MODEL1310110051#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_63f7bd1a_41e1_463b_bd75_5e9a8425d82b
initial concentration: NaN
constant: false
is encoded by: hsa:2629
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: GBA
has only substance units: false
type: Species

metaM melatn c
type: Species
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
is: CHEBI:16796
is: HMDB01389
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: melatonin
constant: false
boundary condition: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM pd3 c
initial amount: NaN
is: HMDB06500
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
name: Previtamin D3
has only substance units: false
constant: false

metaR r2084
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM q10 e
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial amount: NaN
is: CHEBI:46245
constant: false
name: ubiquinone-10
is: HMDB01072
is: SBO:0000247
has only substance units: false

metaR NADPHtxu
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
name: NADPH transporter, peroxisome
fast: false

metaR r1380
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110051#
fast: false
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_de67f9b1_e973_4bfd_a571_2d845439c28d
type: Species
name: _100287639_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:100287639
boundary condition: true
initial amount: NaN

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR EX 34hpp
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM 4nph c
type: Species
is: SBO:0000247
initial amount: NaN
name: 4-nitrophenolate
initial concentration: 1.0
is: CHEBI:57917
has only substance units: false
boundary condition: false
is: HMDB01232
constant: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870

metaR C180CPT1
is: SBO:0000176
reversible: false
product: MODEL1310110051#
name: production of stearoylcarnitine
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269

metaM cs e deg7 l
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:15936
boundary condition: false
constant: false
notes: FORMULA: C23H35O27S2 CHARGE: -3
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_87941413_47dc_4b4a_80dd_80e156797181
initial concentration: NaN
constant: false
name: SLC7A8:SLC3A2
type: Species
is: SBO:0000297
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:23428
has part: Q9UHI5

metaM Ssq23epx r
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
name: (S)-2,3-epoxysqualene
is: SBO:0000247
is: HMDB01188
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: CHEBI:15441
initial concentration: 1.0

metaM nadph m
is: C00005
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
type: Species
is: HMDB00221

metaR r0552
type: Reaction
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
product: MODEL1310110051#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110051#

metaM ksi pre9 g
constant: false
has only substance units: false
is: HMDB00175
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00130
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 9
is: SBO:0000247
is: CHEBI:58053

metaR r1634
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185

metaR PSFLIPm
reversible: false
product: MODEL1310110051#
name: phosphatidylserine flippase
kinetic law: MODEL1310110051#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.1

metaR CHSTEROLtrc
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
kinetic law: MODEL1310110051#
is described by: ECO:0000134
name: transport of cholesterol into the cytosol
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#

metaR FACOAL246 1
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
type: Reaction

metaR PPAm
is: SBO:0000176
name: inorganic diphosphatase
product: MODEL1310110051#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_3b94a4f1_de54_420d_b95c_7a40e210bf05
initial amount: NaN
has only substance units: false
name: COX7B
initial concentration: NaN
type: Species
is: P24311
boundary condition: true
constant: false
is encoded by: hsa:1349
is: SBO:0000252

metaM ru5p D r
initial amount: NaN
is: HMDB00618
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58121
has only substance units: false
type: Species
initial concentration: 1.0
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM hs deg4 l
initial concentration: 1.0
name: heparan sulfate, degradation product 4
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16126
notes: FORMULA: C73H104N4O92S10 CHARGE: -12

metaM ddeccrn c
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C19H37NO4 CHARGE: 0
is: HMDB02250
initial amount: NaN
has only substance units: false
constant: false
name: lauroyl carnitine

metaR TETPENT6COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
fast: false
reactant: MODEL1310110051#
type: Reaction
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
product: MODEL1310110051#
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_a463630b_d412_4a8c_a493_07ec62dd6bfb
is encoded by: hsa:197257
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: LDHD
is: SBO:0000252

metaM gtp m
is: C00044
is: SBO:0000247
boundary condition: false
is: HMDB01273
constant: false
is: CHEBI:37565
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
initial concentration: 1.0
name: GTP
has only substance units: false

metaM octa e
boundary condition: false
name: octanoate (n-C8:0)
initial concentration: 1.0
initial amount: NaN
type: Species
is: C06423
is: HMDB00482
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
constant: false
is: SBO:0000247
has only substance units: false

metaM C05957 r
initial amount: NaN
boundary condition: false
type: Species
name: Prostaglandin J2
initial concentration: 1.0
constant: false
is: CHEBI:27485
has only substance units: false
is: HMDB02710
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957

metaR r1635
product: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110051#

metaR RE3001M
is described by: ECO:0000000
name: RE3001
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.34
product: MODEL1310110051#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction

metaM dec47dicoa m
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
name: 4,7-decadienoylcoa
type: Species
has only substance units: false
initial amount: NaN

metaM q10 c
type: Species
is: HMDB01072
is: CHEBI:46245
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
initial concentration: 1.0
name: ubiquinone-10
boundary condition: false

metaM 3hodcoa m
initial amount: NaN
name: (S)-3-Hydroxyoctadecanoyl-CoA
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
has only substance units: false
constant: false
boundary condition: false

metaR G6PDH1rer
reversible: true
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.47
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110051#

metaR FAOXC225C204m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR RE2799C
is: SBO:0000176
reversible: true
name: RE2799
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000

metaR PPAn
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
name: inorganic diphosphatase, nuclear
kinetic law: MODEL1310110051#
reversible: false

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_0c7e69d3_1317_4161_8c41_1f9806958cd5
boundary condition: true
is: SBO:0000252
is: P22304
initial amount: NaN
is encoded by: hsa:3423
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: IDS

metaR GLYCtm
is: SBO:0000185
type: Reaction
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
name: glycerol transport
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV

metaM glu5sa m
is: HMDB02104
is: SBO:0000247
boundary condition: false
has only substance units: false
name: L-Glutamate 5-semialdehyde
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: C01165
is: CHEBI:17232
initial amount: NaN
type: Species
initial concentration: 1.0

metaM pmtcrn m
is: SBO:0000247
is: CHEBI:17490
is: HMDB00222
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine

metaR RE3326M
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4
name: RE3326
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
modifier: MODEL1310110051#
product: MODEL1310110051#

metaR r2081
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
is described by: ECO:0000000

metaR TMNDNCCPT1
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110051#
modifier: MODEL1310110051#
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110051#
type: Reaction
fast: false

metaM ddeccrn e
name: lauroyl carnitine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C19H37NO4 CHARGE: 0
is: HMDB02250
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

metaR r1632
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000000

metaR ACACt2m
product: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000269
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reversible: true
name: Acetoacetate mitochondrial transport via H+ symport
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_aecebe5e_bbb5_4307_adad_3ce464a29755
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: TUSC3
boundary condition: true
is: Q13454
initial amount: NaN
is encoded by: hsa:7991

http://identifiers.org/biomodels.db/MODEL1310110051#_855296be_294c_4c99_8246_215cbb64837c
name: ACOT6
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:641372
initial concentration: NaN
initial amount: NaN
type: Species
is: Q3I5F7
has only substance units: false

metaR r2080
is: SBO:0000185
type: Reaction
product: MODEL1310110051#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110051#

metaM dectricoa m
constant: false
has only substance units: false
is: SBO:0000247
name: 2,4,7-decatrienoylcoa
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
type: Species
boundary condition: false

metaM octa c
initial concentration: 1.0
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
is: C06423
initial amount: NaN
has only substance units: false
is: HMDB00482
is: CHEBI:25646
name: octanoate (n-C8:0)
constant: false
is: SBO:0000247
boundary condition: false

metaR ACOAO7p
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
product: MODEL1310110051#

metaR BAMPPALDOX
reversible: false
is described by: ECO:0000212
is: SBO:0000176
modifier: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110051#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_0bc7c976_0407_4deb_a039_0195ce8ed66b
is encoded by: hsa:4594
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: MUT
initial concentration: NaN
constant: false
is: P22033
type: Species

metaM dolglcp L r
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
type: Species
is: CHEBI:15812

metaR TMNDNCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110051#
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction

metaM hpdcacrn c
is: HMDB06210
constant: false
boundary condition: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: heptadecanoyl carnitine

metaR r0553
type: Reaction
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110051#
kinetic law: MODEL1310110051#

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
is: SBO:0000176
reactant: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction

metaR r1633
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR C180CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
name: carnitine O-stearoyl transferase

metaM hs deg12 l
is: CHEBI:17180
is: SBO:0000247
name: heparan sulfate, degradation product 12
has only substance units: false
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
initial amount: NaN
is: HMDB01352
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_7e228f91_aa28_436b_a806_5191550f79d6
type: Species
has only substance units: false
is: Q6ZWP6
is encoded by: hsa:27034
name: ACAD8
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_4ab62d95_1576_4d0f_9e22_7433e111ef4c
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:84720
has only substance units: false
constant: false
is encoded by: hsa:5281
type: Species
has part: Q07326
boundary condition: true
name: PIGF:PIGO
initial amount: NaN
has part: Q8TEQ8

http://identifiers.org/biomodels.db/MODEL1310110051#_25b65a98_83f5_4dce_bc91_56ca13627fdd
is: Q9NPH0
is: SBO:0000252
has only substance units: false
name: ACP6
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:51205
constant: false

metaM 3thexddcoa m
has only substance units: false
is: HMDB02014
initial amount: NaN
name: 3-hydroxy trans7,10-hexadecadienoylcoa
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C37H58N7O18P3S CHARGE: -4

metaR TMDS
is version of: http://identifiers.org/ec-code/2.1.1.45
reversible: false
modifier: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
name: thymidylate synthase
kinetic law: MODEL1310110051#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:

metaM glu L e
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
name: L-glutamate(1-)
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:29985
has only substance units: false
initial amount: NaN

metaR S6T1g
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_4cf1fdc4_6337_4b6a_811c_8aa1c5d8e50d
boundary condition: true
is: Q9UHI5
initial amount: NaN
is encoded by: hsa:23428
name: SLC7A8
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaR PA HStg
name: phosphatidate scramblase
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
fast: false

metaR ASNGLNNaEx
product: MODEL1310110051#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false

metaM 3mop e
is: CHEBI:28654
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
constant: false
initial amount: NaN
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
is: HMDB00491
type: Species
boundary condition: false

metaM dolglcp L c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
type: Species
constant: false
is: CHEBI:15812
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_aa38e60a_bbbb_43d4_be0c_07eeaa9812ed
name: PIGW
type: Species
boundary condition: true
constant: false
is: Q7Z7B1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:284098
initial amount: NaN

metaR HDDACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM so3 c
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: Sulfite
is: CHEBI:17137
is: HMDB00240

metaR HMGCOARc
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
is version of: http://identifiers.org/ec-code/1.1.1.34
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000134
kinetic law: MODEL1310110051#
type: Reaction
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is: SBO:0000176
reversible: false
product: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_8c0e7e64_7cd2_49a9_8480_c87f9badc731
constant: false
initial concentration: NaN
is: A8K3J4
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23632
has only substance units: false
name: CA14
type: Species

metaM hdd2crn c
type: Species
initial amount: NaN
is: HMDB06317
constant: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
is: SBO:0000247
name: trans-Hexadec-2-enoyl carnitine
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b068132a_957d_4e3b_a5e8_1798b43334df
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:51557
initial concentration: NaN
has only substance units: false
is: Q5TDP6
is: SBO:0000252
name: LGSN
type: Species

metaM mn l
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
has only substance units: false
name: beta-1,4-mannose-N-acetylglucosamine
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06535
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d473f73c_4a30_45e6_9a1c_5bd71d462948
initial concentration: NaN
is: B2R6S5
has only substance units: false
is encoded by: hsa:51727
boundary condition: true
name: CMPK1
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaR r0470
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110051#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110051#_bd612822_7b54_4310_a651_4b11dae70b1f
name: NDUFA8
type: Species
initial concentration: NaN
is: SBO:0000252
is: B1AM93
initial amount: NaN
is encoded by: hsa:4702
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_89880828_a1bf_4682_bcb2_1c7ede297a8f
is: SBO:0000252
is encoded by: hsa:AA081045
initial amount: NaN
name: _AA081045_1_c
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_f7618072_036f_4437_88c4_542d80d0de8a
constant: false
boundary condition: true
is: SBO:0000252
name: ACAT2
initial concentration: NaN
is: Q9BWD1
is encoded by: hsa:39
type: Species
initial amount: NaN
has only substance units: false

metaR PEROXx
reversible: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
name: peroxisomal lumped long chain fatty acid oxidation
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_ce5a81b0_7409_4153_9f58_2a0fd673129e
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:126129
is: Q8TCG5
name: CPT1C
constant: false
initial concentration: NaN
boundary condition: true

metaR RE1804M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
type: Reaction
modifier: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
name: RE1804
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_7a9a2332_f78f_473c_8cf3_0ce794dd3189
is: Q9NY59
name: SMPD3
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55512
has only substance units: false
is: SBO:0000252

metaR C101CRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR MI4PP
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.3.25
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
name: myo-inositol 4-phosphatase
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
kinetic law: MODEL1310110051#

metaM tetpent3coa x
boundary condition: false
is: C16167
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-3
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_c437e634_3d83_41af_84b5_5d221d2facee
initial concentration: NaN
initial amount: NaN
name: OGDHL
is encoded by: hsa:55753
has only substance units: false
type: Species
is: Q9ULD0
constant: false
boundary condition: true
is: SBO:0000252

metaM gtp n
initial amount: NaN
name: GTP(4-)
boundary condition: false
constant: false
is: HMDB01273
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
is: CHEBI:37565
initial concentration: 1.0
has only substance units: false

metaM udpglcur r
initial concentration: 1.0
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
boundary condition: false
is: CHEBI:58052
has only substance units: false
initial amount: NaN
is: HMDB00935
type: Species
name: UDP-D-glucuronate
is: SBO:0000247
is: C00167

metaM Rtotalcoa c
constant: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
has only substance units: false
name: R total Coenzyme A
initial concentration: 1.0
is: CHEBI:16189
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01448

metaM Sfglutth c
is: CHEBI:57688
is: HMDB01550
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: S-formylglutathionate(1-)
constant: false
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_615b79d3_4bc3_4449_99e1_f2fc4047049a
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: GGT5
has only substance units: false
is encoded by: hsa:2687
boundary condition: true
is: P36269
is: SBO:0000252

metaM 3mop c
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:28654
initial amount: NaN
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
name: 3-methyl-2-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110051#_2c9f4559_c296_42c4_8650_6797870066e8
constant: false
boundary condition: true
type: Species
is encoded by: hsa:10327
name: AKR1A1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P14550
has only substance units: false

metaM nadph x
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
type: Species
is: C00005
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_db248d99_6c2f_42bc_82ca_8b5b4ab32d8e
name: ME3
initial concentration: NaN
type: Species
is encoded by: hsa:10873
is: Q6TCH8
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaR r0472
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110051#
is: SBO:0000176
name: beta-galactosidase, lysosomal
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000

metaR EX c81crn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_e6ac608f_3fba_4b4f_b29f_f46b32c0a515
initial amount: NaN
type: Species
is encoded by: hsa:AI469183
constant: false
is: SBO:0000252
boundary condition: true
name: _AI469183_1_x
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_0e0f8b6d_cae7_4112_90ed_be03adaf31f4
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:BE966236
initial concentration: NaN
constant: false
name: _BE966236_1_m
is: SBO:0000252

metaR DMHPTCRNte
type: Reaction
is: SBO:0000185
reactant: MODEL1310110051#
product: MODEL1310110051#
reversible: true
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
name: 2,6 dimethylheptanoyl carnitine transport
is described by: ECO:0000000

metaR BHBt
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
reversible: true
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate transport via H+ symport
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_70247305_1403_40d0_b7b5_dd1d17dffd8e
has only substance units: false
initial amount: NaN
name: PIGV
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55650
type: Species
is: Q9NUD9

metaR ADSL1
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.3.2.2
name: adenylosuccinate lyase
reversible: false

metaM paps c
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01134
is: CHEBI:58339
initial amount: NaN
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: SBO:0000247
constant: false
has only substance units: false

metaR r0475
fast: false
product: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110051#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR r1381
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
fast: false
reactant: MODEL1310110051#

metaM HC00250 e
name: hydrosulfide
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR RPEc
is: SBO:0000176
type: Reaction
product: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
is described by: ECO:0000134
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
name: ribulose 5-phosphate 3-epimerase

metaR NP1
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
name: nucleotide phosphatase
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110051#
is described by: ECO:0000304
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: false

metaM HC01444 e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Galactosylglycerol
initial amount: NaN
is: CHEBI:15754
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401

metaR VACCCRNt
name: transport into the mitochondria (carnitine)
reversible: false
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
fast: false
is described by: ECO:0000269

metaM tmndnccoa c
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: timnodonyl coenzyme A
is: HMDB06514
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0
initial amount: NaN

metaR r0474
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110051#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110051#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110051#

metaR r0321
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is version of: http://identifiers.org/ec-code/6.3.5.2
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: false
type: Reaction

metaM pyr m
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3324
type: Species
boundary condition: false
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
name: pyruvate
is: C00022
is: HMDB00243

http://identifiers.org/biomodels.db/MODEL1310110051#_0bd71fd2_0521_431b_9282_156edd973bc6
constant: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:7991
boundary condition: true
type: Species
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has only substance units: false
initial amount: NaN

metaM ca2 e
boundary condition: false
name: calcium(2+)
is: SBO:0000247
type: Species
constant: false
is: HMDB00464
is: CHEBI:29108
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076

metaM msa m
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
name: 3-oxopropanoate
is: HMDB11111
initial concentration: 1.0
initial amount: NaN
is: CHEBI:33190

metaR DM dgpi prot hs r
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaR UDPtl
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
type: Reaction
fast: false
name: udp intracellular transport
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_dc448be8_8678_4e57_84b0_d16568152d61
name: TXNRD2
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:10587

metaM hpdcacrn m
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: HMDB06210
type: Species
name: heptadecanoyl carnitine
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM ksi deg23 l
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 23
has only substance units: false
constant: false
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C124H201N8O106S5 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110051#_038097ea_0a02_4af3_94ac_302ac48f86cf
is encoded by: hsa:79717
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: PPCS
type: Species
initial concentration: NaN
is: Q9HAB8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_484f0308_f335_4f20_b29d_8d24d9f8c3f0
initial amount: NaN
type: Species
name: LDHD
has only substance units: false
is: Q86WU2
is: SBO:0000252
is encoded by: hsa:197257
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_6d92dfe8_a9d4_4937_8e3d_b2c507a06b74
constant: false
type: Species
is encoded by: hsa:6818
boundary condition: true
name: SULT1A3
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM HC01496 m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
has only substance units: false
name: 2-Amino-3-oxoadipate
type: Species
is: CHEBI:28095

http://identifiers.org/biomodels.db/MODEL1310110051#_5ebdfdc2_5930_488a_b2ca_a3809ed8a64a
initial amount: NaN
name: SLC38A4
type: Species
is: Q969I6
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:55089

http://identifiers.org/biomodels.db/MODEL1310110051#_c14c488b_89d7_4d17_91e1_0cde65d3ae18
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: GPI
has only substance units: false
is encoded by: hsa:2821
type: Species
is: P06744
is: SBO:0000252

metaM 2mbcoa m
initial amount: NaN
is: CHEBI:57336
is: HMDB01041
has only substance units: false
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 2-methylbutanoyl-CoA(4-)

metaM m8mpdol L r
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:59093
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
is: SBO:0000247
has only substance units: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false

metaM glu L c
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
name: L-glutamate(1-)
is: CHEBI:29985
is: HMDB00148
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_206d9813_eb68_445c_b8a1_3ffe9459e353
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: DHFR
is encoded by: hsa:1719
initial amount: NaN
constant: false
is: P00374
has only substance units: false

metaR ADSL2
kinetic law: MODEL1310110051#
reversible: false
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.3.2.2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
name: adenylosuccinate lyase
is: SBO:0000176
type: Reaction
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_e2a1be40_3f73_4cfd_95a9_101cee5b5ca6
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: O75438
type: Species
has only substance units: false
is encoded by: hsa:4707
name: NDUFB1
initial amount: NaN

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR FAOXC102C101m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR HEXCt
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110051#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#

metaR r1384
is: SBO:0000176
name: Guanosine aminohydrolase EC:3.5.4.15
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
reversible: true

metaM trdrd c
name: Reduced thioredoxin
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15967
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM ca2 c
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
is: CHEBI:29108
is: HMDB00464

metaR GRTTx
is version of: http://identifiers.org/ec-code/2.5.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
name: geranyltranstransferase
kinetic law: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
reversible: false
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000134

metaR r2193
reactant: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
fast: false

metaM hs deg20 l
has only substance units: false
type: Species
name: heparan sulfate, degradation product 20
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:16126
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM dc2coa m
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
name: trans-Dec-2-enoyl-CoA
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:61406
boundary condition: false
initial concentration: 1.0
constant: false

metaR r0246
reversible: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110051#

metaM atp x
is: SBO:0000247
is: HMDB00538
constant: false
name: ATP(4-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57299
has only substance units: false
type: Species
is: C00002
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b3cd8522_ef85_431e_9102_3af81eb3e87f
name: FH
type: Species
initial concentration: NaN
is: P07954
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2271

metaM pyr c
type: Species
boundary condition: false
is: C00022
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1
constant: false
initial amount: NaN
is: CHEBI:15361
name: pyruvate
initial concentration: 1.0
is: HMDB00243

metaR FATP1t
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
type: Reaction
name: fatty acid electroneutral transport
reversible: true
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_ad61d9f4_481f_4515_817e_9674db5f2e11
name: ST8SIA5
initial amount: NaN
is encoded by: hsa:29906
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: O15466

metaR GLCNACASE5ly
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaM 3hmp m
boundary condition: false
name: 3-hydroxy-2-methylpropanoate
constant: false
is: HMDB00023
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
type: Species
is: SBO:0000247
is: CHEBI:11805
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_f0b47af0_2dd1_4c8c_9e51_d949516585ef
is: P49888
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: SULT1E1
boundary condition: true
is encoded by: hsa:6783
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_42845525_5e4d_4b0c_99bd_090079c14a06
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:84890
initial amount: NaN
is: B3KXN9
constant: false
initial concentration: NaN
name: ADO
has only substance units: false

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_249674c1_4cfc_4aa5_b0bf_e7725021d7fd
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q13510
is encoded by: hsa:427
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: ASAH1

metaR NH4t3r
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
type: Reaction
product: MODEL1310110051#
name: ammonia transport via proton antiport
kinetic law: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
is: SBO:0000185

metaM man1p c
is: CHEBI:35374
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: HMDB06330
constant: false
boundary condition: false
name: D-Mannose 1-phosphate
type: Species
initial amount: NaN

metaM m3mpdol L c
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
is: CHEBI:37632
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX 3octdece1crn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR GAO2g
product: MODEL1310110051#
name: Ganglioside O-acetylation
kinetic law: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ

metaR PTE3x
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
fast: false
product: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
name: peroxisomal acyl-CoA thioesterase
kinetic law: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b36289ca_84b6_4829_ae17_ba3f7d69fb30
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5152
name: PDE9A
type: Species

metaM pyr e
initial amount: NaN
is: HMDB00243
name: pyruvate
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

metaM hestratriol c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: 4,17 dihydroxy estradiol
is: HMDB05896
initial amount: NaN
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
type: Species

metaR r0139
type: Reaction
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110051#

metaR TSTSTERONESte
kinetic law: MODEL1310110051#
type: Reaction
name: sulfonated testosterone transport
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_639947e3_dda5_418a_8723_068ed9b6a4d5
name: PYCRL
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q53H96
is encoded by: hsa:65263
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR r0245
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reactant: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110051#
type: Reaction
fast: false

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM cys L c
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00574
is: CHEBI:17561
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
name: L-cysteine

metaM hs deg13 l
constant: false
has only substance units: false
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: SBO:0000247
type: Species
boundary condition: false
name: heparan sulfate, degradation product 13
is: CHEBI:17180
initial concentration: 1.0
initial amount: NaN
is: HMDB01352

metaM glx c
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
is: HMDB00119
type: Species
is: CHEBI:36655
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR ESTRONEtr
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: estrone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR C142OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110051#_2bde9573_3657_4cad_8097_ae55caa5957e
is: SBO:0000252
name: PLCL1
is encoded by: hsa:5334
is: Q15111
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_de1aebb6_c196_49f3_a668_b14d3d854b1a
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI285872
has only substance units: false
type: Species
name: _AI285872_1_c
boundary condition: true
constant: false
initial concentration: NaN

metaR GALSGLT1le
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_4f45600d_4f22_4287_b73e_4d8b1e5c88cb
is encoded by: hsa:5151
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: PDE8A
type: Species
initial amount: NaN
is: SBO:0000252

metaR r0892
name: Facilitated diffusion
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.2.27
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR FAOXC122C101m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR r0242
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
product: MODEL1310110051#
type: Reaction
fast: false
is: SBO:0000176

metaM HC01412 x
is: SBO:0000247
is: CHEBI:61405
constant: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: trans-tetradec-2-enoyl-CoA(4-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_222e57ed_2ae1_410c_a956_6a7552ba0c1d
type: Species
constant: false
name: ACHE
initial amount: NaN
has only substance units: false
is encoded by: hsa:43
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_450f9519_dd6c_44a5_a39d_e10b8311b583
is encoded by: hsa:5471
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q06203
name: PPAT

metaR PHCDm
reversible: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
product: MODEL1310110051#

metaM CE2838 e
is: http://identifiers.org/pubchem.compound/5041
name: maltononaose
is: C01936
initial amount: NaN
type: Species
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaM ppcoa x
is: C00100
name: Propanoyl-CoA
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
is: HMDB01275
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57392

metaR SEBCOAPET
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_e9b7a677_09f3_4f89_9afd_b3d5fbae8ffd
is: P39656
is encoded by: hsa:1650
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: DDOST
has only substance units: false
initial amount: NaN

metaM tmndnccoa m
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
name: timnodonyl coenzyme A

metaR r0780
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
fast: false
modifier: MODEL1310110051#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#

metaR r0009
kinetic law: MODEL1310110051#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
product: MODEL1310110051#
fast: false
is: SBO:0000176
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#

metaR C142OHe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaM 3thexddcoa c
boundary condition: false
is: HMDB02014
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: 3-hydroxy trans7,10-hexadecadienoylcoa
notes: FORMULA: C37H58N7O18P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110051#_3360d8a6_3c04_446c_8b82_247cb4c61a76
initial concentration: NaN
is: G5E960
name: PLCB3
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:5331

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM ksii core2 pre5 g
has only substance units: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: HMDB00175
is: C00130
name: keratan sulfate II biosynthesis, precursor 5
is: SBO:0000247
constant: false
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR UPPN
modifier: MODEL1310110051#
name: b-ureidopropionase
is version of: http://identifiers.org/ec-code/3.5.1.6
fast: false
reversible: false
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_506aa8fb_a794_4c4f_9d11_ffc2b809ba35
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: CHAT
initial amount: NaN
has only substance units: false
is encoded by: hsa:1103
boundary condition: true
is: Q6LEN6

http://identifiers.org/biomodels.db/MODEL1310110051#_5396ed17_2058_439f_bad9_9136514bb7ec
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P49448
has only substance units: false
is encoded by: hsa:2747
initial amount: NaN
constant: false
name: GLUD2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_8b53c243_ed27_48ad_b153_a703b504201f
constant: false
is: SBO:0000252
initial amount: NaN
name: HSD17B4
boundary condition: true
initial concentration: NaN
has only substance units: false
is: E9PB82
type: Species
is encoded by: hsa:3295

metaM acgal c
initial amount: NaN
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00212
is: SBO:0000247
boundary condition: false
is: CHEBI:28037
name: N-acetyl-D-galactosamine

http://identifiers.org/biomodels.db/MODEL1310110051#_ddc5b9e9_799e_4385_b8ff_1d6a19ccfeb8
initial amount: NaN
is: SBO:0000252
name: _22305_2_c
boundary condition: true
has only substance units: false
is encoded by: hsa:22305
constant: false
type: Species
initial concentration: NaN

metaR O2tm
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: O2 transport (diffusion)
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is: SBO:0000185
reversible: true

metaR FAOXC2452256x
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110051#
type: Reaction
reversible: false
kinetic law: MODEL1310110051#

metaM cspg a l
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
constant: false
initial amount: NaN
is: HMDB02183
is: CHEBI:36005

http://identifiers.org/biomodels.db/MODEL1310110051#_c17e062c_1e9b_4050_86a8_15aab4f23f3d
constant: false
name: ALDH1A2
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8854
is: O94788

http://identifiers.org/biomodels.db/MODEL1310110051#_689f84a3_e821_415e_8896_d59d8b48c72a
is: SBO:0000252
name: ENPP1
has only substance units: false
is encoded by: hsa:5167
boundary condition: true
is: P22413
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM Tn antigen l
has only substance units: false
is: C04383
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: Tn antigen
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
initial amount: NaN

metaM 3docopencoa m
type: Species
initial amount: NaN
name: 3,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_3bc76552_e022_47b4_b8da_3938ac5e2055
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR FAOXC184C164m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_8919b9db_a05c_468d_b281_a75c011576fe
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: SULT2A1
is: SBO:0000252
is encoded by: hsa:6822
has only substance units: false
initial amount: NaN
is: Q06520

metaR r0668
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.19
kinetic law: MODEL1310110051#

metaM acgam6p c
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: CHEBI:57513
initial concentration: 1.0
is: HMDB01062
initial amount: NaN
boundary condition: false
name: N-acetyl-D-glucosamine 6-phosphate(2-)
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_1ffdd452_98cd_4d2a_bb52_2d0c1e213a64
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ATG9B
is encoded by: hsa:285973
has only substance units: false
initial concentration: NaN
type: Species
is: Q674R7
constant: false

metaM doco13ac e
is: HMDB02068
name: docosenoic acid (C22:1)
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C22H41O2 CHARGE: -1

metaR O2tp
kinetic law: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110051#
type: Reaction
name: O2 transport, peroxisomal
fast: false
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM ksi deg38 l
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 38
is: HMDB00143
is: CHEBI:12936
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false

metaM hdca l
is: HMDB00220
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
type: Species
boundary condition: false
name: palmitate
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_941f1e7b_88ca_41e4_b7e8_ed55661afc73
is: SBO:0000252
is encoded by: hsa:9469
name: CHST3
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q7LGC8

http://identifiers.org/biomodels.db/MODEL1310110051#_e9717560_71ab_4a4b_969d_2716d624e618
constant: false
type: Species
is: Q9HBF5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:400410
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ST20

metaR LEUKTRB4t
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
name: leukotriene B4 transport
type: Reaction
is: SBO:0000185

metaR r0669
fast: false
is: SBO:0000176
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:

metaM hdcoa c
has only substance units: false
name: Hexadecenoyl-CoA (n-C16:1CoA)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB06532
constant: false
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

metaR DOPAt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
product: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
is: SBO:0000185

metaM pmtcoa c
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01338
is: CHEBI:3454
is: C00154
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_00a3111d_7d56_4b5c_b480_2e6cba0cc479
type: Species
name: ALDH4A1
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8659
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_af3bc7dc_02a5_4a4f_9a45_fc5ea534f02a
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3155
is: SBO:0000252
is: Q6IBC0
name: HMGCL
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_835f53f0_07a4_4cfa_b02f_f3eaa10358f0
initial concentration: NaN
name: SLC2A4
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:6517
is: SBO:0000252
boundary condition: true
is: P14672
has only substance units: false

metaR DOPAtu
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: Dopamine uniport
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_bc6ea3fa_e0e6_493b_8189_4c188d58e3d1
boundary condition: true
is: Q9HAB8
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PPCS
type: Species
is: SBO:0000252
is encoded by: hsa:79717

metaR ADK3m
reactant: MODEL1310110051#
name: adentylate kinase (GTP)
type: Reaction
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
product: MODEL1310110051#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_bbccb7ba_fd8e_4b60_867c_0719b6a8ece2
is: Q6IA69
is encoded by: hsa:55191
has only substance units: false
initial concentration: NaN
name: NADSYN1
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR DLNLCGCPT2
is: SBO:0000176
name: carnitine transferase
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
reversible: false
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_9774836c_d2f2_471c_9332_052e26928b33
constant: false
has only substance units: false
initial amount: NaN
is: Q13615
name: MTMR3
is encoded by: hsa:8897
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_feaa5c63_5657_42f9_841d_677e165c39ce
is encoded by: hsa:6482
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: ST3GAL1

metaR r0783
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
product: MODEL1310110051#
type: Reaction
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM cdp n
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
has only substance units: false
is: HMDB01546
constant: false
is: CHEBI:58069
name: CDP(3-)
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM acnacngalgbside hs e
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00036
type: Species
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
constant: false
is: CHEBI:3338
name: disialyl galactosylgloboside
is: HMDB00223
has only substance units: false

metaR r1617
product: MODEL1310110051#
is: SBO:0000185
modifier: MODEL1310110051#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110051#

metaM hdca r
is: CHEBI:7896
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
type: Species
is: HMDB00220
is: C00249
name: Hexadecanoate (n-C16:0)
initial amount: NaN

metaR S6T17g
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110051#

metaM retinal cis 9 r
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17898
initial amount: NaN
boundary condition: false

metaM nadph c
is: HMDB00221
type: Species
is: SBO:0000247
is: CHEBI:57783
constant: false
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005

metaR DLNLCGCPT1
modifier: MODEL1310110051#
name: carnitine O-palmitoyltransferase
fast: false
is described by: ECO:0000000
product: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110051#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_314cee13_820c_4b50_ac82_6bcd1bb2e57c
initial amount: NaN
name: SLC7A9
constant: false
has only substance units: false
is encoded by: hsa:11136
is: SBO:0000252
is: P82251
initial concentration: NaN
type: Species
boundary condition: true

metaR FAOXC241181x
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:1 -> c18:1 - 3 rounds beta-ox 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110051#
fast: false
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
is: SBO:0000176
type: Reaction

metaM leuktrC4 c
initial concentration: 1.0
name: leukotriene C4(2-)
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973

metaR r2346
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaR r1616
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM glx m
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
is: CHEBI:36655
name: glyoxylate
is: HMDB00119
type: Species
is: SBO:0000247
boundary condition: false

metaM HC01412 m
is: SBO:0000247
name: trans-tetradec-2-enoyl-CoA(4-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:61405
constant: false

metaM 3mgcoa m
type: Species
constant: false
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial amount: NaN
is: HMDB01057
name: trans-3-methylglutaconyl-CoA(5-)
is: CHEBI:57346
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM so4 c
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
boundary condition: false
is: CHEBI:16189
initial amount: NaN
type: Species
name: sulfate
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01448

metaR r0784
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
fast: false
is described by: ECO:0000000

metaM bildglcur c
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM retn r
is: HMDB01852
type: Species
constant: false
is: CHEBI:35291
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: all-trans-retinoate
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_9b23afb1_c29f_45e1_b2de_163bb011b8d4
is: SBO:0000252
name: SULT2B1
boundary condition: true
constant: false
is encoded by: hsa:6820
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

metaR r0559
reactant: MODEL1310110051#
fast: false
type: Reaction
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
reversible: true
modifier: MODEL1310110051#

metaR r0002
fast: false
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_61c4d6c5_a97f_4990_a1bb_b938a773d39b
constant: false
initial amount: NaN
boundary condition: true
name: RDH12
is encoded by: hsa:145226
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q96NR8

http://identifiers.org/biomodels.db/MODEL1310110051#_c515fe26_7c9c_4afe_bea4_dc73f4c87d7e
initial concentration: NaN
is: P54315
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5407
boundary condition: true
name: PNLIPRP1
constant: false

metaM acnacngalgbside hs g
has only substance units: false
boundary condition: false
is: C00036
constant: false
type: Species
is: CHEBI:3338
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: HMDB00223
name: disialyl galactosylgloboside
is: SBO:0000247
initial amount: NaN

metaR r1619
is: SBO:0000185
type: Reaction
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000000
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
product: MODEL1310110051#

metaR r2347
is: SBO:0000185
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110051#

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR 3MOBte
product: MODEL1310110051#
name: Transport of 3-methyl-2-oxobutanoate
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000134
reactant: MODEL1310110051#

metaR PCHOLPg hs
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
name: choline phosphatase
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#

metaR FAOXC184C164x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaM ksi deg39 l
type: Species
constant: false
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00143
name: keratan sulfate I, degradation product 39
notes: FORMULA: C48H81N3O36 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_48f3bdcb_5ed0_46fe_8d7f_4f29e2de27b8
is encoded by: hsa:8574
name: AKR7A2
initial concentration: NaN
initial amount: NaN
is: O43488
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ce88fbeb_8795_4b45_93e9_ff2eec7b42fa
name: TYMP
has only substance units: false
is encoded by: hsa:1890
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: P19971
boundary condition: true
constant: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR 4MOPt2im
reactant: MODEL1310110051#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: false

metaR r1618
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: true
fast: false
reactant: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM leuktrC4 e
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
has only substance units: false
is: HMDB01198
initial amount: NaN
is: CHEBI:57973
constant: false
type: Species
name: leukotriene C4(2-)
boundary condition: false
is: SBO:0000247

metaR AG13T15g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110051#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
product: MODEL1310110051#
type: Reaction

metaR DOLPGT1 Ler
type: Reaction
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.267
reactant: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD

metaR CRNtx
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: carnitine transport peroxisome to mitochondria
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_48817256_5c1a_4c48_acaf_849fa8c93209
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI090874
name: _AI090874_1_c
constant: false
initial concentration: NaN

metaR MI134P4P
name: inositol-1,3,4-trisphosphate 4-phosphatase
reactant: MODEL1310110051#
product: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false

metaM ksii core2 deg8 l
is: HMDB00143
has only substance units: false
type: Species
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 8
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C36H60N3O25X CHARGE: 0
constant: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110051#_f8e92047_dcec_4eab_a128_032cf4f6da21
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: AK2
initial concentration: NaN
is encoded by: hsa:204

metaR r1613
fast: false
product: MODEL1310110051#
reversible: true
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#

metaM hestratriol e
boundary condition: false
type: Species
initial amount: NaN
is: HMDB05896
name: 4,17 dihydroxy estradiol
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false
is: SBO:0000247

metaR FAOXC121x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR r0787
type: Reaction
product: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false

metaR HDCACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_d15e7aa3_9352_4019_a1a5_ffc3415f7411
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10678
boundary condition: true
name: B3GNT2
initial concentration: NaN
initial amount: NaN

metaR INSTt4
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
name: inositol transport via sodium symport
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000269

metaR H2CO3D
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
name: carboxylic acid dissociation
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaM c4dc c
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
has only substance units: false
constant: false
name: succinyl carnitine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false
is: C02862
type: Species
is: HMDB02013

metaM HC01397 x
is: CHEBI:27402
boundary condition: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial concentration: 1.0

metaM 7dhf e
initial amount: NaN
type: Species
has only substance units: false
name: heptaglutamyl folate (DHF)
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
boundary condition: false
constant: false
is: HMDB06559
initial concentration: 1.0
is: SBO:0000247

metaR Htx
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: H transporter, peroxisome
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reversible: true
fast: false

metaM ha l
is: CHEBI:16336
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: hyaluronan
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
constant: false
initial amount: NaN
boundary condition: false

metaM adpac c
notes: FORMULA: C6H8O4 CHARGE: -2
boundary condition: false
name: adipic acid
type: Species
is: HMDB00448
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM ksi deg22 l
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
name: keratan sulfate I, degradation product 22
is: SBO:0000247
is: HMDB01354
initial concentration: 1.0
is: CHEBI:57455

http://identifiers.org/biomodels.db/MODEL1310110051#_1a4e8c58_b79c_4833_8e9e_4cc4f9ca6a54
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AW299740
initial concentration: NaN
is: SBO:0000252
name: _AW299740_1_m
constant: false

metaM pmtcoa m
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
is: HMDB01338
boundary condition: false
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaR r0788
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true

metaR r1612
is: SBO:0000185
modifier: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_01b9b2a2_dad1_470e_93b3_6d1dca965cbb
type: Species
is: SBO:0000252
name: AK2
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:204
has only substance units: false
is: P54819

metaM cys L e
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561
has only substance units: false
name: L-cysteine
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00574

http://identifiers.org/biomodels.db/MODEL1310110051#_f16d556c_7900_4f45_b032_e2fe0b10e261
type: Species
is: SBO:0000252
name: UROD
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P06132
initial amount: NaN
is encoded by: hsa:7389

metaR CYTK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110051#
reversible: true
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: cytidylate kinase (dCMP),nuclear

metaM acnacngalgbside hs c
initial amount: NaN
is: CHEBI:3338
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
is: HMDB00223
is: C00036
initial concentration: 1.0
name: disialyl galactosylgloboside

http://identifiers.org/biomodels.db/MODEL1310110051#_13c96ed5_40b8_4fd0_aa9e_8bdd73c30d70
initial amount: NaN
name: SLC15A2
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:6565
is: Q16348
boundary condition: true

metaM tmndnccoa x
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
name: timnodonyl coenzyme A
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

metaR r1615
reversible: true
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false

metaM ppcoa m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00100
name: Propanoyl-CoA
is: HMDB01275
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaM hs deg24 l
constant: false
is: SBO:0000247
notes: FORMULA: C31H50NO26 CHARGE: -1
type: Species
initial concentration: 1.0
is: CHEBI:16126
initial amount: NaN
has only substance units: false
boundary condition: false
name: GlcNAc-GlcA-(Gal)2-Xyl

http://identifiers.org/biomodels.db/MODEL1310110051#_efdb2b67_4c07_4f05_80f1_a2b38ec12c48
is encoded by: hsa:10948
is: B4DUY1
boundary condition: true
has only substance units: false
name: STARD3
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_488a6caa_9ad4_4125_b4e3_514f3ef41715
name: ETFB
is encoded by: hsa:2109
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P38117
constant: false
type: Species
boundary condition: true

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_5ed28170_5dc1_420e_95f9_cfc7bd44b8fe
is: Q9H2H9
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:81539
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC38A1

http://identifiers.org/biomodels.db/MODEL1310110051#_f92c1659_812a_41a5_bba2_6ce008ea8b3b
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AA081045
initial amount: NaN
name: _AA081045_1_e
initial concentration: NaN
constant: false
boundary condition: true

metaR C161CPT12
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110051#

metaM dctp c
initial amount: NaN
boundary condition: false
name: dCTP
is: C00458
is: HMDB00998
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
initial concentration: 1.0
is: CHEBI:16311
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_fa6f08aa_f03a_4e39_8881_0814c3dcb4c5
is encoded by: hsa:80339
initial concentration: NaN
is: Q9NST1
constant: false
is: SBO:0000252
name: PNPLA3
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaM dectricoa x
constant: false
type: Species
is: SBO:0000247
name: 2,4,7-decatrienoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H44N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110051#_b90b602e_3eec_490f_b001_26b324d8829e
is: Q13057
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: COASY
has only substance units: false
type: Species
is encoded by: hsa:80347

metaM dc2coa x
initial concentration: 1.0
is: HMDB01168
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
boundary condition: false
name: trans-Dec-2-enoyl-CoA

metaR r1614
modifier: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0249
is version of: http://identifiers.org/ec-code/2.7.7.12
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
reversible: true
is: SBO:0000176

metaR UDPGALtg
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
reversible: true
fast: false
type: Reaction
name: UDP-Gal Golgi transport via CMP antiport

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaM cspg a e
initial concentration: 1.0
type: Species
is: C00106
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
has only substance units: false
boundary condition: false
is: HMDB00300
constant: false
is: SBO:0000247
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial amount: NaN
is: CHEBI:17568

http://identifiers.org/biomodels.db/MODEL1310110051#_2f7c922d_2bc4_4341_b9cf_edc52220e76f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:259230
has only substance units: false
type: Species
boundary condition: true
name: SGMS1
constant: false
initial amount: NaN
is: D3DWC4

metaM andrstndn r
is: HMDB00053
type: Species
boundary condition: false
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
initial concentration: 1.0
is: CHEBI:16422
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: androst-4-ene-3,17-dione

metaM ksii core4 pre5 g
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: CHEBI:58053
initial concentration: 1.0
is: HMDB00175
type: Species
has only substance units: false
boundary condition: false
is: C00130
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
constant: false
is: SBO:0000247

metaM cdp m
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:58069
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
name: CDP(3-)
is: HMDB01546
initial concentration: 1.0

metaM so4 e
boundary condition: false
initial amount: NaN
name: sulfate
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
type: Species
is: HMDB01448
has only substance units: false
initial concentration: 1.0
is: CHEBI:16189

metaR r1620
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true
type: Reaction

metaM ala L c
name: L-alanine
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: CHEBI:16977
initial amount: NaN
initial concentration: 1.0
is: HMDB00161
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_7889e734_4d80_4031_853c_20c27057f260
constant: false
has only substance units: false
is: SBO:0000252
name: PRDX1
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5052
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_94ebe000_4ac2_4755_be1c_4a43f5c76c30
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q5JWV8
initial concentration: NaN
is encoded by: hsa:2182
name: ACSL4
constant: false
type: Species

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR FAOXC10C8m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

metaR PHCHGSm
type: Reaction
fast: false
kinetic law: MODEL1310110051#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reactant: MODEL1310110051#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD

metaM ksii core4 deg2 l
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
name: keratan sulfate II (core 4-linked), degradation product 2
boundary condition: false
initial concentration: 1.0

metaR r0671
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.22
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
reversible: false
is: SBO:0000176
reactant: MODEL1310110051#
fast: false
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:

metaR RE0383C
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
is: SBO:0000176
reversible: true
type: Reaction
name: RE0383
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is described by: ECO:0000000

metaR HPYRRy
type: Reaction
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
reversible: false
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.1.1.79
reactant: MODEL1310110051#
name: Hydroxypyruvate reductase (NADPH)
is: SBO:0000176

metaR ABTti
kinetic law: MODEL1310110051#
name: L-arabinitol transport via passive diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_0df4a11f_36bc_4c18_8d91_7d88ecb3d142
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is: P00390
name: GSR
type: Species
is encoded by: hsa:2936
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_ea8feebb_41c7_406f_a0dd_1617a461328d
constant: false
is: SBO:0000252
type: Species
name: GOT1
has only substance units: false
is: P17174
is encoded by: hsa:2805
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_eb14bde9_f68a_439f_bde5_4284bc13f0ee
is: SBO:0000252
name: SCD
initial concentration: NaN
type: Species
is encoded by: hsa:6319
is: O00767
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaR PROD2
product: MODEL1310110051#
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
name: Proline dehydrogenase
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.5.99.8
kinetic law: MODEL1310110051#
fast: false

metaM gpail hs c
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
type: Species
is: SBO:0000247
is: CHEBI:17049
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_75c5fac5_6483_4b1a_894d_a9bfee4fa577
initial concentration: NaN
is encoded by: hsa:T83654
initial amount: NaN
name: _T83654_1_c
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false

metaM CE2422 m
initial amount: NaN
is: HMDB11123
is: CHEBI:28387
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaR C3STDH1Pr
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
is described by: ECO:0000134
product: MODEL1310110051#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
modifier: MODEL1310110051#

metaR DURItn
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
name: deoxyuridine transport in nucleus
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#

metaR S6TASE24ly
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

metaR r1621
modifier: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#
is described by: ECO:0000000

metaR r0779
is: SBO:0000176
fast: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110051#_22ada1c4_129c_4623_b478_c3159883fcd6
is: SBO:0000252
boundary condition: true
name: GBA
initial amount: NaN
is encoded by: hsa:2629
constant: false
is: B7Z5G2
type: Species
initial concentration: NaN
has only substance units: false

metaR r0670
fast: false
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
reactant: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

metaM 5forthf c
is: HMDB01534
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: CHEBI:57456
is: C00664
boundary condition: false
initial amount: NaN
type: Species
name: 5-Formiminotetrahydrofolate

metaM core6 g
name: Core 6
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
is: CHEBI:16478
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaM hdcoa m
has only substance units: false
initial concentration: 1.0
type: Species
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: HMDB06532

http://identifiers.org/biomodels.db/MODEL1310110051#_fcb7a2ee_1f45_4660_9dcb_b9bf8efa055c
is: B3KUN3
initial concentration: NaN
boundary condition: true
name: AHCY
is: SBO:0000252
is encoded by: hsa:191
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR FACOAL184
fast: false
modifier: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110051#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#

metaM xol7aone c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
initial concentration: 1.0
is: CHEBI:17899
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR RE2658R
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
type: Reaction
product: MODEL1310110051#
reversible: true
name: RE2658
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000

metaR ARABR
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
name: arabinose reductase
is described by: ECO:0000269
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2

metaM ins c
is: C00294
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
is: HMDB00195
is: CHEBI:17596
boundary condition: false
has only substance units: false

metaM urea e
initial concentration: 1.0
is: CHEBI:16199
boundary condition: false
name: Urea
is: SBO:0000247
has only substance units: false
is: HMDB00294
initial amount: NaN
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
constant: false
type: Species
is: C00086

metaR ACACT1r
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110051#
type: Reaction
reversible: true
name: acetyl-CoA C-acetyltransferase
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is described by: ECO:0000000
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM ala L e
is: SBO:0000247
type: Species
name: L-alanine
has only substance units: false
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
is: CHEBI:16977
initial concentration: 1.0
constant: false
is: HMDB00161

metaR r1622
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_a6d2c1ed_0438_44bd_b8aa_cb688a472626
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6173
name: RPL36A
is: P83881
initial amount: NaN
boundary condition: true

metaM pchol hs m
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16110
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial amount: NaN
name: Phosphatidylcholine

metaM dcmp c
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247
name: dCMP
initial concentration: 1.0
boundary condition: false
is: HMDB01202
is: CHEBI:57566
is: C00239
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR ASNtN1
is: SBO:0000185
fast: false
product: MODEL1310110051#
name: Asparagine transport (Na, H coupled)
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110051#

metaM bilirub c
is: HMDB00054
has only substance units: false
boundary condition: false
constant: false
name: bilirubin(2-)
is: SBO:0000247
is: CHEBI:57977
initial amount: NaN
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0

metaR r1623
modifier: MODEL1310110051#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM cit m
is: CHEBI:16947
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
name: Citrate
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00094

http://identifiers.org/biomodels.db/MODEL1310110051#_c320d7c8_15f4_4585_9272_34b4a4b851b8
initial concentration: NaN
is: E9PCI1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:53
is: SBO:0000252
constant: false
name: ACP2

metaM stcoa c
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
type: Species
is: CHEBI:57394
constant: false
boundary condition: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM ins e
is: C00294
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17596
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: HMDB00195
name: Inosine
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_7482cbff_d9dd_41f8_8ed9_f1803a59e3f6
name: NDUFA12
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55967
initial concentration: NaN
type: Species
boundary condition: true
is: F8VQS7
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_90aaca69_3fbd_4145_ba8d_37625b31420e
has only substance units: false
type: Species
name: OGDH
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q02218
initial concentration: NaN
is encoded by: hsa:4967

metaR r2342
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_a2bd529f_b40a_4724_ab8b_82c50ec252cd
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:1375
name: CPT1B
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: E9PCP2

http://identifiers.org/biomodels.db/MODEL1310110051#_f72c95b5_d551_461d_8636_7664bb2ed202
boundary condition: true
name: SLC25A26
has only substance units: false
constant: false
is: SBO:0000252
is: F8WAB8
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:115286

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_e071f24e_80e5_43e0_a2b2_6fac24bd278e
initial amount: NaN
is encoded by: hsa:6574
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q8WUM9
name: SLC20A1

http://identifiers.org/biomodels.db/MODEL1310110051#_8ad5b153_92bc_490e_9e6c_d177261f634d
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: _AI024818_1_c
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:AI024818

metaR r1830
reversible: false
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r0130
is: SBO:0000176
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
type: Reaction
fast: false
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_d72d8122_848b_4d75_b1a7_94271f0ce5d5
is encoded by: hsa:4125
initial concentration: NaN
constant: false
initial amount: NaN
name: MAN2B1
has only substance units: false
boundary condition: true
is: O00754
is: SBO:0000252
type: Species

metaM cdp c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:58069
name: CDP
has only substance units: false
is: C00112
type: Species
is: HMDB01546

metaR G14T7g
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false

metaR LNLNCGCRNt
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reversible: false
name: transport into the mitochondria (carnitine)
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#

metaR ACNAM9PL
type: Reaction
product: MODEL1310110051#
reversible: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
kinetic law: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.56

metaR TSTSTERONEtr
reversible: true
name: testosterone intracellular transport
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000

metaR H4ETer
is: SBO:0000176
reversible: false
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
fast: false
is described by: ECO:0000000

metaM pchol hs g
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
name: Phosphatidylcholine
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16110
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ec3f8f90_e50c_43ed_a5c7_7987df91e1d3
is: SBO:0000252
is: Q4J699
initial concentration: NaN
constant: false
type: Species
name: ATP2B2
is encoded by: hsa:491
initial amount: NaN
boundary condition: true
has only substance units: false

metaR FUCASEe
reactant: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.51
is: SBO:0000176
name: alpha-fucosidase, extracellular
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#

metaM xtsn c
constant: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: HMDB00299
name: xanthosine
initial amount: NaN
boundary condition: false
is: CHEBI:18107
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM lanost r
name: lanosterol
has only substance units: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial concentration: 1.0
is: CHEBI:16521
boundary condition: false
is: HMDB01251
is: SBO:0000247

metaM ha e
is: SBO:0000247
name: hyaluronan
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16336
constant: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
initial amount: NaN

metaM atp c
initial amount: NaN
name: ATP(4-)
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00002
is: CHEBI:30616
is: HMDB00538
boundary condition: false
constant: false

metaM thexddcoa m
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: trans7,10-hexadecadienoylcoa
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
is: HMDB02288

metaM bilirub e
is: HMDB00054
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57977
boundary condition: false
is: SBO:0000247
type: Species
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaR r0355
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_0823c4db_3217_4b77_b28f_cc12b150b2fb
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51196
boundary condition: true
is: Q9P212
has only substance units: false
constant: false
type: Species
name: PLCE1
is: SBO:0000252

metaR DALAt2r
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
name: D-alanine transport via proton symport
is described by: ECO:0000304
product: MODEL1310110051#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#

metaR FAOXC163x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaM c3dc e
constant: false
boundary condition: false
is: HMDB02095
type: Species
initial amount: NaN
has only substance units: false
name: malonyl carnitine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H16NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110051#_55610ca4_e045_404f_ac76_7aa4c1da1ef7
name: DHCR24
type: Species
is: Q15392
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1718
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r2341
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
fast: false

metaM estrone c
is: HMDB00145
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: estrone
boundary condition: false
is: CHEBI:17263
constant: false
type: Species

metaM 5dhf e
initial amount: NaN
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
name: pentaglutamyl folate (DHF)
is: HMDB06487
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaM core6 l
constant: false
type: Species
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
name: Core 6
boundary condition: false
initial concentration: 1.0
is: HMDB00143

metaR r2344
kinetic law: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_0fc3e107_3b59_4c04_b32b_0ba87c58e8f1
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:7498
is: P47989
name: XDH
is: SBO:0000252
boundary condition: true

metaR r1832
fast: false
reversible: false
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0354
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reactant: MODEL1310110051#
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
is: SBO:0000176

metaM cdp e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:58069
has only substance units: false
is: HMDB01546
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)

metaR LNLNCGt
type: Reaction
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: fatty acid transport via diffusion

metaM leu L e
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:15603
name: L-leucine

metaR EX c3dc
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR C140CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaR SPHK21c
product: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
fast: false
name: sphingosine kinase 2
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.91
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
reversible: false

metaR r2343
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction

metaR BILIRUBtr
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
fast: false
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
name: lipid, flip-flop intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_4cc8895f_deb8_4c91_88bb_a08a3aa59c37
name: PLD1
is: Q59EA4
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5337
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaR ALASm
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.37
name: 5-aminolevulinate synthase
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.29
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reversible: false
fast: false

metaM atp e
constant: false
is: CHEBI:57299
boundary condition: false
initial concentration: 1.0
name: ATP(4-)
is: C00002
is: HMDB00538
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

metaM urea c
constant: false
is: CHEBI:16199
type: Species
is: C00086
name: Urea
is: SBO:0000247
has only substance units: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00294

metaM c3dc c
name: malonyl carnitine
is: SBO:0000247
is: HMDB02095
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H16NO6 CHARGE: -1
type: Species

metaR PROt4 2 r
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
name: Proline transport (sodium symport) (2:1)
is described by: ECO:0000006
is: SBO:0000185
kinetic law: MODEL1310110051#
reversible: true
type: Reaction
modifier: MODEL1310110051#

metaR ACACT1x
modifier: MODEL1310110051#
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is: SBO:0000176
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_4a3811b3_c9dd_4cce_8ac9_3742a6aee78c
constant: false
name: UEVLD
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q8IX04
has only substance units: false
is encoded by: hsa:55293

metaR HCO3 CLt
is: SBO:0000185
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269
name: bicarbonate transport (Cl-/HCO3- exchange)
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
fast: false
modifier: MODEL1310110051#

metaR RE1527M
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
name: RE1527
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
modifier: MODEL1310110051#
reversible: true
product: MODEL1310110051#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_49d34b83_7eab_4801_9c9e_0debbd5a285f
constant: false
is: P14410
type: Species
has only substance units: false
is encoded by: hsa:6476
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SI
is: SBO:0000252

metaM zym int2 r
name: zymosterol intermediate 2
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
is: CHEBI:52386
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaM mi1p D c
is: HMDB02985
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: CHEBI:58433
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_05a4fb97_36e6_48c9_b112_bb1df868eaf3
constant: false
is encoded by: hsa:3290
type: Species
name: HSD11B1
is: P28845
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_27314e93_206a_48ba_a740_b36d4bffcfab
is: SBO:0000252
boundary condition: true
is: Q9NRX3
name: NDUFA4L2
constant: false
initial amount: NaN
is encoded by: hsa:56901
initial concentration: NaN
type: Species
has only substance units: false

metaM 3htdcoa m
is: HMDB02288
name: (S)-3-Hydroxytetradecanoyl-CoA
type: Species
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR DOLPMT1 Ler
reversible: false
kinetic law: MODEL1310110051#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#

metaR G14T20g
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM pchol hs c
type: Species
initial concentration: 1.0
is: CHEBI:16110
constant: false
initial amount: NaN
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_53032728_1b74_4b24_9181_52576677cdc1
has part: A7E2E0
boundary condition: true
is encoded by: hsa:5293
type: Species
has part: Q92569
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:8503
has only substance units: false
initial concentration: NaN
name: PIK3CD:PIK3R3
constant: false

metaM hdca c
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate
initial concentration: 1.0
boundary condition: false
is: HMDB00220

metaR r0974
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
type: Reaction
kinetic law: MODEL1310110051#
reversible: true
name: Active transport
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM ump c
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: UMP
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57865
is: C00105
boundary condition: false

metaM leu L c
name: L-leucine
is: CHEBI:15603
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247

metaM Tn antigen g
name: Tn antigen
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H14NO5X CHARGE: 0
is: C04383
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR r0679
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
fast: false
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
product: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_dca194a6_0906_45a9_802c_632c6101bc49
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O76062
name: TM7SF2
type: Species
constant: false
is encoded by: hsa:7108

metaM ksii core4 pre9 g
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 9
boundary condition: false
has only substance units: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM cit c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
constant: false
type: Species
is: HMDB00094
initial concentration: 1.0
is: CHEBI:16947
is: C00158
name: Citrate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_5e0d1497_58c6_4ab4_a969_f44d591d154b
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: PLCB4
is: E2QRH8
initial amount: NaN
type: Species
is encoded by: hsa:5332

metaR r0973
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
kinetic law: MODEL1310110051#
name: Facilitated diffusion
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_60f2124e_2c38_49c0_b81a_ae34d8c0f18d
constant: false
is encoded by: hsa:8802
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: P53597
initial concentration: NaN
initial amount: NaN
name: SUCLG1

http://identifiers.org/biomodels.db/MODEL1310110051#_7234e6bb_f24e_4f0b_b558_644aa32ae505
constant: false
is encoded by: hsa:1962
boundary condition: true
has part: Q9NY65
has only substance units: false
name: EHHADH:ACAA1:ACOX1
is: SBO:0000297
type: Species
initial concentration: NaN
initial amount: NaN

metaR r0464
product: MODEL1310110051#
fast: false
reversible: true
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
type: Reaction
reactant: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110051#

metaR GLUTCOAACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaM stcoa m
is: C00412
type: Species
has only substance units: false
is: CHEBI:57394
name: Stearoyl-CoA (n-C18:0CoA)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB01114
constant: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412

metaR MI1PP
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
name: myo-inositol 1-phosphatase
modifier: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.25
reversible: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
is described by: ECO:0000269
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_e66ecd96_b70a_41ea_8b73_b6144bed1684
is: B7Z428
initial concentration: NaN
type: Species
is encoded by: hsa:10020
initial amount: NaN
is: SBO:0000252
name: GNE
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_24f875a8_dc00_452a_92c8_37bd3163533d
type: Species
constant: false
initial concentration: NaN
name: AK4
is: P27144
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:205

metaR RE1516M
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: RE1516
type: Reaction

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_0ab0604b_5bfa_4e9d_92e5_f1da52ff62be
constant: false
initial amount: NaN
is encoded by: hsa:4695
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: O43678
is: SBO:0000252
name: NDUFA2

http://identifiers.org/biomodels.db/MODEL1310110051#_98490a1b_beb3_4d9c_bd42_9466a67d551d
initial concentration: NaN
is: SBO:0000252
is: E9PAK4
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: SLC5A9
is encoded by: hsa:200010

metaM 3dhguln c
initial amount: NaN
constant: false
initial concentration: 1.0
name: 3-dehydro-L-gulonate
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: CHEBI:57655
is: HMDB06334
type: Species
boundary condition: false
is: SBO:0000247

metaM 2octpencoa m
boundary condition: false
type: Species
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
name: 2,6,9,12,15-octadecapentenoylcoa
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR VACCCPT1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
name: carnitine O-palmitoyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
product: MODEL1310110051#

metaR r0463
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
fast: false
type: Reaction
is described by: ECO:0000000

metaR ACOAD9m
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM cit e
boundary condition: false
constant: false
type: Species
name: citrate(3-)
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
is: CHEBI:16947
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR GLUNm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110051#
name: glutaminase (mitochondrial)
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.2
reactant: MODEL1310110051#

metaR ACOAD1fm
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110051#

metaM atp r
type: Species
has only substance units: false
is: HMDB00538
constant: false
initial amount: NaN
is: CHEBI:57299
is: C00002
is: SBO:0000247
initial concentration: 1.0
name: ATP(4-)
boundary condition: false

metaM dctp n
name: dCTP
is: SBO:0000247
type: Species
is: CHEBI:16311
is: C00458
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00998
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458

http://identifiers.org/biomodels.db/MODEL1310110051#_93d65efa_1802_4382_99f2_1107728400ba
is encoded by: hsa:6240
is: P23921
name: RRM1
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_cda91e17_d818_481b_93ac_7ab1b5176d49
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI824319
constant: false
name: _AI824319_1_r
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR DNDPt15m
reactant: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
modifier: MODEL1310110051#
name: dUDP transport via dGDP antiport
is: SBO:0000185
kinetic law: MODEL1310110051#
reversible: false

metaR VACCCPT2
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is: SBO:0000176
product: MODEL1310110051#
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaM arachcoa x
name: arachidyl coenzyme A
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:15527
is: HMDB04258

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
fast: false
reversible: true
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110051#
kinetic law: MODEL1310110051#

metaM atp m
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57299
initial concentration: 1.0
type: Species
is: HMDB00538
initial amount: NaN
name: ATP(4-)
is: C00002
has only substance units: false

metaR S6T2g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
modifier: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000

metaR NAHCO3 HCLt
reactant: MODEL1310110051#
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
name: bicarbonate transport (HCl/NaHCO3 exchange)
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reversible: true
product: MODEL1310110051#
fast: false
is described by: ECO:0000269
type: Reaction

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_dc2eb508_ad94_49bf_b277_4d79f5a8c2e8
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AA854479
name: _AA854479_1_m
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR C6CRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

metaM tridcoa m
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB13109
has only substance units: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
name: tridecanoylcoa

metaR DMHPTCRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
name: 2,6 dimethylheptanoyl crn transport
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_b5723f60_1f81_4a74_86ba_05343d531268
boundary condition: true
is: Q9BZQ4
initial concentration: NaN
name: NMNAT2
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:23057

metaM C05965 e
is: CHEBI:57444
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 12(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: HMDB04243
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ac899728_eb9f_437c_ab20_728def0776ac
initial amount: NaN
has part: Q8WYR1
has only substance units: false
is: SBO:0000297
initial concentration: NaN
constant: false
name: PIK3R5:PIK3CG
is encoded by: hsa:23533
type: Species
boundary condition: true

metaR r1117
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
fast: false
product: MODEL1310110051#
name: Facilitated diffusion
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
is: SBO:0000185

metaR AHEXASE2ly
reversible: false
product: MODEL1310110051#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD

metaM HC01408 m
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27648
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
name: 3-Oxohexanoyl-CoA
type: Species
initial amount: NaN

metaR PPA
type: Reaction
modifier: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.6.1.1
name: inorganic diphosphatase
fast: false

metaM sbcoa x
name: suberylcoa
constant: false
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species
is: SBO:0000247
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
boundary condition: false
initial amount: NaN

metaR RE0512M
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110051#
reversible: true
name: RE0512
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110051#_f58a7362_1a47_45cc_bf57_7238b98339d0
name: ENTPD8
boundary condition: true
is: Q5MY95
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:377841
type: Species
has only substance units: false

metaR RE3556C
reversible: true
type: Reaction
name: RE3556
is described by: ECO:0000000
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110051#
product: MODEL1310110051#

metaM m6mpdol L r
is: CHEBI:37635
constant: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20

metaM acgal l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
name: N-acetyl-D-galactosamine
boundary condition: false
is: CHEBI:28037
is: HMDB00212
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM hdca e
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: C00249
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1
boundary condition: false
name: Hexadecanoate (n-C16:0)
is: CHEBI:0
initial concentration: 1.0
is: HMDB00220

metaR GLB1
name: Beta-galactosidase
modifier: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110051#_ce8c6c15_8e11_4475_9764_838c065ba63d
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:2530
has only substance units: false
name: FUT8
is: SBO:0000252
initial amount: NaN
is: Q9BYC5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_a98e7c24_cff3_4987_a8bc_fd03181f5633
is: SBO:0000252
is: A8K596
name: SARDH
initial amount: NaN
is encoded by: hsa:1757
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR r0560
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
product: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR LCADi
reactant: MODEL1310110051#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110051#
is: SBO:0000176
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36

http://identifiers.org/biomodels.db/MODEL1310110051#_695f23dd_7c10_4dca_83fd_3c5cf5374eb7
type: Species
initial concentration: NaN
name: LDHA
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3939
constant: false
is: P00338
is: SBO:0000252

metaR MI1PS
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
is version of: http://identifiers.org/ec-code/5.5.1.4
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
reversible: false
is described by: ECO:0000269
name: myo-Inositol-1-phosphate synthase
type: Reaction
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176

metaR MEOHt2
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110051#
name: Methanol diffusion
type: Reaction
is: SBO:0000185

metaR PCHOLPr hs
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
name: choline phosphatase
product: MODEL1310110051#
kinetic law: MODEL1310110051#

metaR FAOXC17C15m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_b7a4f039_2535_484f_84c4_9287bc60955f
is encoded by: hsa:4952
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: OCRL
is: Q01968
has only substance units: false
type: Species
is: SBO:0000252

metaM atp n
boundary condition: false
is: CHEBI:57299
constant: false
name: ATP(3-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial concentration: 1.0
is: HMDB00538
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_c70ca408_c128_4963_8413_6790d75ae8b0
is encoded by: hsa:10965
type: Species
has only substance units: false
is: SBO:0000252
name: ACOT2
is: P49753
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM dece4coa m
initial concentration: 1.0
is: SBO:0000247
is: HMDB02145
initial amount: NaN
constant: false
name: 4-decenoylcoa
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
has only substance units: false
boundary condition: false

metaM hexccoa x
is: SBO:0000247
name: Hexacosanoyl-CoA (n-C26:0CoA)
initial concentration: 1.0
boundary condition: false
is: HMDB06459
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR DDCRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_0679fa01_971b_49e5_ae96_74c1315b429a
is encoded by: hsa:80025
type: Species
initial concentration: NaN
name: PANK2
is: Q6P1K9
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_a5d89100_1493_42e6_8b6b_0e7675de738e
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:222
constant: false
name: ALDH3B2
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: P48448

metaR r1116
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110051#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110051#

metaM dcmp n
is: HMDB01202
type: Species
initial amount: NaN
constant: false
name: dCMP(2-)
boundary condition: false
is: CHEBI:57566
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

http://identifiers.org/biomodels.db/MODEL1310110051#_a9d5b0c9_c6bc_48a9_9ae7_9041408cfbf4
is: SBO:0000252
is encoded by: hsa:6534
name: SLC6A7
constant: false
is: Q99884
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaM ksii core4 pre4 g
is: SBO:0000247
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
is: C00130
notes: FORMULA: C61H99N5O43X CHARGE: -1
type: Species
boundary condition: false
constant: false

metaM 3ohdcoa x
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349
type: Species
is: HMDB06402
has only substance units: false
constant: false
is: SBO:0000247

metaM citr L m
constant: false
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
boundary condition: false
is: CHEBI:16349
name: L-citrulline
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00904

metaR GLYCTDle
name: difussion of glycerol accross the brush border membrane
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_c6b43a69_acd6_4552_a855_d453a083f119
type: Species
is encoded by: hsa:9152
constant: false
name: SLC6A5
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9Y345

metaM ditp n
is: HMDB03537
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: dITP(4-)
is: SBO:0000247
is: CHEBI:61382

metaR r0127
reversible: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000176
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_a29c3733_db4f_4e75_ab43_e40c4645f305
is: Q9H008
is encoded by: hsa:64077
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: LHPP
boundary condition: true
constant: false

metaM hs deg14 l
is: CHEBI:16126
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
name: heparan sulfate, degradation product 14
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_5dcbde2f_6f09_456f_b7f8_9d640df44d24
is encoded by: hsa:5831
initial concentration: NaN
has only substance units: false
is: P32322
name: PYCR1
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_83ff8682_4bce_42da_b9bc_e9995181c127
is: Q02318
name: CYP27A1
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1593
constant: false

metaM utp n
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:46398
constant: false
has only substance units: false
type: Species
is: HMDB00285
name: UTP(4-)

metaM pre prot r
is: HMDB03125
has only substance units: false
notes: FORMULA: XY CHARGE: 0
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: CHEBI:16240

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM m3gacpail hs r
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: SBO:0000247
is: CHEBI:16240
has only substance units: false
initial amount: NaN
is: HMDB03125
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_d70753b8_dc49_4854_85b3_5e56ef95a427
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: HCST
constant: false
type: Species
initial concentration: NaN
is: Q9UBK5
is encoded by: hsa:10870

metaR SIAASE4ly
type: Reaction
fast: false
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is: SBO:0000176
product: MODEL1310110051#

metaR GLCNACASE3ly
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50

http://identifiers.org/biomodels.db/MODEL1310110051#_9af090fa_5169_42c3_9ace_eef393a6d277
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3030
boundary condition: true
is: E9KL44
constant: false
name: HADHA

http://identifiers.org/biomodels.db/MODEL1310110051#_70d09e59_ad7b_4aaf_89b3_c1a92f406c16
is: B7Z792
type: Species
is encoded by: hsa:4720
constant: false
is: SBO:0000252
has only substance units: false
name: NDUFS2
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR CHOLD2m
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
reactant: MODEL1310110051#
reversible: false
modifier: MODEL1310110051#
name: choline dehydrogenase (FAD acceptor), mitochondrial
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/1.1.99.1
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110051#
is described by: ECO:0000269

metaM 3htdcoa c
name: (S)-3-Hydroxytetradecanoyl-CoA
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
initial amount: NaN
is: HMDB02014
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_e16a4f01_dc60_4968_919f_19a8513ce335
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q99808
type: Species
is encoded by: hsa:2030
initial amount: NaN
name: SLC29A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0a5768a4_6136_4a3d_bb28_b24485c4fab3
initial concentration: NaN
constant: false
is encoded by: hsa:157570
is: SBO:0000252
initial amount: NaN
is: Q56NI9
type: Species
boundary condition: true
name: ESCO2
has only substance units: false

metaR RE1807M
type: Reaction
modifier: MODEL1310110051#
name: RE1807
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
is: SBO:0000176

metaM HC02210 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
type: Species
is: SBO:0000247
constant: false
is: CHEBI:34939
name: prostaglandin-d3
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM oxa m
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
type: Species
is: CHEBI:30623
initial concentration: 1.0
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110051#_13c50b84_f609_4dd0_a189_dae1e7421051
boundary condition: true
is encoded by: hsa:6487
is: SBO:0000252
initial concentration: NaN
constant: false
name: ST3GAL3
has only substance units: false
initial amount: NaN
type: Species

metaR r0129
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true
modifier: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
product: MODEL1310110051#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

http://identifiers.org/biomodels.db/MODEL1310110051#_550176ea_7e23_4a67_aba4_a998e0302875
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7167
type: Species
constant: false
boundary condition: true
is: Q53HE2
name: TPI1
initial concentration: NaN

metaR ATPtm
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: false
name: ADP/ATP transporter, mitochondrial
is described by: ECO:0000269
fast: false
modifier: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_96634cc5_bffe_449e_8305_143f3cdd7396
boundary condition: true
constant: false
initial concentration: NaN
name: SLC27A2
type: Species
is: O14975
is encoded by: hsa:11001
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM HC00342 c
has only substance units: false
boundary condition: false
is: SBO:0000247
name: cis-aconitate(3-)
initial concentration: 1.0
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
constant: false
type: Species
is: CHEBI:16383

metaM c6dc x
has only substance units: false
name: adipoyl carnitine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C13H22NO6 CHARGE: -1
initial amount: NaN
is: HMDB04047
type: Species
is: C14143
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_a7510683_f37c_45ad_84a2_1e679b6ce4b7
name: _R33828_1_c
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:R33828
is: SBO:0000252
type: Species
has only substance units: false

metaM dece4coa x
boundary condition: false
is: SBO:0000247
name: 4-decenoylcoa
has only substance units: false
is: HMDB02145
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_cb975072_b9cc_440a_b86a_32f494d77124
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: SLC23A2
is: Q9UGH3
type: Species
boundary condition: true
is encoded by: hsa:9962
initial concentration: NaN

metaM 25aics c
is: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: HMDB00797
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: CHEBI:58443
boundary condition: false
is: SBO:0000247
constant: false

metaR RE2759X
reversible: true
is version of: http://identifiers.org/ec-code/5.1.99.4
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
name: RE2759
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
fast: false

metaM bilirub r
is: HMDB00054
has only substance units: false
is: CHEBI:57977
name: bilirubin(2-)
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaR PMANM
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.4.2.2
reversible: true
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
name: phosphomannomutase
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_f145c07d_c6bd_4352_8188_d29a93ce50f2
is: P00491
boundary condition: true
is encoded by: hsa:4860
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PNP

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR CYTK1n
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_59f2e416_a472_4fd6_8a8e_bab3f8358b17
has only substance units: false
initial amount: NaN
name: HSD17B4
initial concentration: NaN
is: E9PB82
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3295
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b38c896a_8b7a_44e6_93f9_8931a2611a9f
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4714
name: NDUFB8
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: O95169

metaM c4dc x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H18NO6 CHARGE: -1
constant: false
name: succinyl carnitine
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: C02862
is: HMDB02013

metaR r0990
product: MODEL1310110051#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
kinetic law: MODEL1310110051#
name: Postulated transport reaction
reactant: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_65706d26_dc53_4a5f_97a5_6e8bc88f008a
is: Q9ULC5
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:51703
boundary condition: true
is: SBO:0000252
name: ACSL5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_69e787a7_c0d5_4057_9766_b1a46547d0ec
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5158
boundary condition: true
is encoded by: hsa:5145
has part: P16499
has part: Q13956
is encoded by: hsa:5149
name: PDE6A:PDE6H:PDE6B
has part: B7Z9T9
constant: false
is: SBO:0000297

metaR FAOXC102C103x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaM CE5132 c
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57923
is: SBO:0000247
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial amount: NaN

metaR CYTK1m
name: cytidylate kinase (CMP),mitochondrial
reversible: true
type: Reaction
product: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000134
reactant: MODEL1310110051#

metaM cmpacna n
constant: false
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaM betald c
is: CHEBI:15710
type: Species
name: betaine aldehyde
constant: false
is: HMDB01252
is: SBO:0000247
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

metaR DURIPP
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
name: deoxyuridine phosphorylase
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
type: Reaction

metaR r2202
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR FATP2t
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110051#
name: fatty acid electroneutral transport
reversible: true

metaR DOLPGT2 Ler
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reversible: false
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.265
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_0f945d66_16fc_4221_9b38_1f5ea6c59eb8
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:622
has only substance units: false
name: BDH1

metaR NACHEX3ly
modifier: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110051#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR OCD11CRNCPT2
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_42473b8d_bc08_4082_a41a_a66dc44fc818
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:6817
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SULT1A1

http://identifiers.org/biomodels.db/MODEL1310110051#_2caddaed_cc65_46bd_893a_3392a9104d22
has only substance units: false
type: Species
is encoded by: hsa:8228
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PNPLA4
is: P41247
constant: false

metaR GLCAASE4ly
is: SBO:0000176
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: beta-glucuronidase, lysosomal
reversible: false
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false

metaR GLYtm
name: glycine passive transport to mitochondria
reactant: MODEL1310110051#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
type: Reaction
reversible: true
product: MODEL1310110051#

metaR ALAGLNexR
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
reversible: true
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#

metaM arachcoa m
initial amount: NaN
has only substance units: false
is: HMDB04258
is: SBO:0000247
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:15527

http://identifiers.org/biomodels.db/MODEL1310110051#_df73630d_fc37_4501_9193_fee89f531fb6
is: SBO:0000252
type: Species
is encoded by: hsa:10195
name: ALG3
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_180e5514_c97a_46b3_87d3_229f66dc587f
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: IDH2
is: P48735
is encoded by: hsa:3418
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR G16MT L
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
product: MODEL1310110051#
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#

metaM pram c
is: HMDB01128
has only substance units: false
is: CHEBI:58681
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
name: 5-Phospho-beta-D-ribosylamine
is: C03090
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_9c0aa77b_8462_4959_a0a8_9ae2d55625a1
is encoded by: hsa:248
is: P09923
boundary condition: true
initial concentration: NaN
name: ALPI
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaR FUMm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.2
name: fumarase, mitochondrial
product: MODEL1310110051#
is described by: ECO:0000134
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
modifier: MODEL1310110051#
type: Reaction

metaR PALFATPtc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_1ab3d110_6274_42e3_ab89_c707583bd383
name: HSD3B7
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80270
type: Species
is: Q9H2F3

metaR GLYtp
name: glycine passive transport to peroxisome
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110051#_257caa43_29bc_4266_8cc5_9030acf9bb5c
initial amount: NaN
is encoded by: hsa:1327
name: COX4I1
is: P13073
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaR r0791
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reversible: true
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176

metaR r1609
is: SBO:0000185
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110051#
fast: false

metaR r2200
is: SBO:0000185
reactant: MODEL1310110051#
reversible: true
product: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110051#

metaR NDP7er
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: false
type: Reaction

metaR r0993
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
is: SBO:0000185
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
reversible: false

metaR DPMVDx
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/4.1.1.33
type: Reaction
reactant: MODEL1310110051#
reversible: false
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000134
name: diphosphomevalonate decarboxylase

metaR FAOXC161C141m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaM dec24dicoa m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,4-decadienoylcoa
is: SBO:0000247

metaM xol27oh m
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02103
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false
name: 26-hydroxycholesterol

metaM HC02187 c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: reverse-triiodthyronine
is: CHEBI:28774
initial concentration: 1.0

metaR r0792
fast: false
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
modifier: MODEL1310110051#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR r1608
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185

metaR r2201
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
type: Reaction
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185

metaR ATP2ter
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
name: AMP/ATP transporter, endoplasmic reticulum
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
reactant: MODEL1310110051#

metaR G6Pter
product: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
fast: false
reversible: true
modifier: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
type: Reaction
kinetic law: MODEL1310110051#

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM HC02210 e
initial concentration: 1.0
name: prostaglandin-d3
is: CHEBI:34939
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_8fdd84e7_590f_4c22_ae95_b1870cc91102
constant: false
name: _AI924226_1_m
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI924226
boundary condition: true
is: SBO:0000252
type: Species

metaR XOLDIOLONEt
name: lipid, flip-flop intracellular transport
is: SBO:0000185
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110051#
type: Reaction
reversible: true
fast: false

metaR r0994
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#

metaR SUCOASm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: true

metaR ATPtx
is: SBO:0000185
reactant: MODEL1310110051#
type: Reaction
reversible: true
name: ATP transporter, peroxisomal
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_21dec39b_2856_41d6_bb7e_4614138fd49e
has only substance units: false
is: P24666
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:52
initial amount: NaN
name: ACP1
constant: false

metaM gly c
is: CHEBI:3339
name: Glycine
is: C00037
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_6a7537de_dee0_4698_8a7b_431773c28381
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q7GXZ4
is encoded by: hsa:4539
name: ND4L
type: Species
boundary condition: true
initial concentration: NaN

metaR TMNDNCt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110051#
is described by: ECO:0000000

metaR FAOXC122x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR r1607
fast: false
kinetic law: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110051#

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
fast: false
reactant: MODEL1310110051#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000000
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110051#
type: Reaction

metaR r2359
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_e7af7e4e_e430_4e45_99eb_10bdec448240
is: SBO:0000252
is: Q16851
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7360
name: UGP2

http://identifiers.org/biomodels.db/MODEL1310110051#_85b4b44f_16ab_4b1c_b47e_62a1eab13253
is encoded by: hsa:8854
is: F5H2Y9
has only substance units: false
constant: false
name: ALDH1A2
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR KSItly
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
name: keratan sulfate I transport, extracellular to lysosome
product: MODEL1310110051#

metaM m2mn l
has only substance units: false
initial amount: NaN
boundary condition: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: SBO:0000247
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
constant: false
initial concentration: 1.0
type: Species
is: HMDB06537

metaR C204CRNt
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
reversible: false
type: Reaction
fast: false
name: arachidonic acid transport into the mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
is described by: ECO:0000000
product: MODEL1310110051#

metaM hexccoa c
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB06459
initial amount: NaN
constant: false
name: Hexacosanoyl-CoA (n-C26:0CoA)

metaM 6hoxmelatn c
is: HMDB04081
is: C05643
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
is: http://identifiers.org/pubchem.compound/7954
initial concentration: 1.0
name: 6-Hydroxymelatonin
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c844cca9_399e_41f7_b828_0e929bf28071
name: HPD
constant: false
boundary condition: true
type: Species
is encoded by: hsa:3242
is: B3KQ63
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_2145e113_d513_43fc_a0ba_8a5d3c6d1e3d
is encoded by: hsa:6648
is: P04179
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: SOD2
constant: false
boundary condition: true
has only substance units: false

metaM ksi pre27 g
constant: false
initial concentration: 1.0
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: C00130
is: HMDB00175
type: Species
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 27
is: CHEBI:58053
has only substance units: false
initial amount: NaN

metaR FACOAL191
type: Reaction
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
name: fatty-acid--CoA ligase
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_96fa2ea3_f3ac_4bce_b50e_df45f5e5cc35
is: F5GY65
boundary condition: true
name: SLC25A11
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:8402
initial amount: NaN
has only substance units: false
constant: false

metaM ksii core2 deg2 l
is: HMDB00143
initial amount: NaN
type: Species
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 2
boundary condition: false
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
constant: false
is: SBO:0000247

metaR r1606
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM pail35p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57923
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5

metaM HC02187 e
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
has only substance units: false
name: reverse-triiodthyronine
is: CHEBI:28774
type: Species
is: SBO:0000247
constant: false
boundary condition: false

metaR ACHEe
reactant: MODEL1310110051#
fast: false
name: Acetylcholinesterase
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.1.7
is: SBO:0000176

metaM docohexcoa m
name: 2,4,7,10,13,16-docosahexenoylcoa
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

metaR PI4PLC
reactant: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
name: phosphatidylinositol 4-phosphate phospholipase C

http://identifiers.org/biomodels.db/MODEL1310110051#_a01fa308_d530_4095_95ec_2fe265d6c561
initial amount: NaN
is: P18283
has only substance units: false
name: GPX2
type: Species
initial concentration: NaN
is encoded by: hsa:2877
is: SBO:0000252
constant: false
boundary condition: true

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_f60277dc_0e81_482d_8038_1973a581d14f
initial concentration: NaN
has only substance units: false
type: Species
is: O94777
constant: false
is: SBO:0000252
initial amount: NaN
name: DPM2
boundary condition: true
is encoded by: hsa:8818

http://identifiers.org/biomodels.db/MODEL1310110051#_779a76e8_5600_4cd2_b389_1e1d8b421d37
has only substance units: false
initial amount: NaN
constant: false
name: CYP2C19
is: P33261
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1557

http://identifiers.org/biomodels.db/MODEL1310110051#_58f63fed_5fe2_40cb_842b_485092c5c099
name: GALT
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: B4E097
is encoded by: hsa:2592
boundary condition: true
initial concentration: NaN
constant: false

metaM gly e
type: Species
name: Glycine
is: C00037
constant: false
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00123
is: CHEBI:3339

http://identifiers.org/biomodels.db/MODEL1310110051#_201bce32_4cad_48ec_9e33_7d84d8852788
is: SBO:0000252
initial amount: NaN
is: P00414
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: COX3
is encoded by: hsa:4514
boundary condition: true

metaR r2357
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110051#
reversible: true
is described by: ECO:0000000

metaR r1605
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_359caada_418b_4064_9dbb_e57ea3278281
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: _AU149534_1_e
initial amount: NaN
is encoded by: hsa:AU149534
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_55283d20_5772_41b9_b9e3_28d3e5313d13
type: Species
is encoded by: hsa:5138
initial amount: NaN
is: Q8IW54
boundary condition: true
name: PDE2A
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaM accoa n
has only substance units: false
boundary condition: false
is: CHEBI:57288
constant: false
initial concentration: 1.0
name: acetyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: SBO:0000247
is: HMDB01206

http://identifiers.org/biomodels.db/MODEL1310110051#_2a856489_9cf6_442f_96eb_392fba96a498
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ACOX1
initial concentration: NaN
is: B4DK61
constant: false
is encoded by: hsa:51

http://identifiers.org/biomodels.db/MODEL1310110051#_7445937f_e17b_40eb_9445_a1ab1755dd63
name: NDUFS6
is: SBO:0000252
is encoded by: hsa:4726
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q6IBC4
constant: false
initial concentration: NaN

metaR DOLPMT4 Ler
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000185
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f3646ad8_e6e6_4604_8079_961450f0afb2
is encoded by: hsa:2717
initial concentration: NaN
boundary condition: true
name: GLA
constant: false
is: SBO:0000252
type: Species
is: Q53Y83
initial amount: NaN
has only substance units: false

metaM CE2433 m
initial amount: NaN
constant: false
boundary condition: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
type: Species
initial concentration: 1.0
is: CHEBI:57795
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433

http://identifiers.org/biomodels.db/MODEL1310110051#_7fa7049f_dc6c_4529_adb9_d548e030a207
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:93183
boundary condition: true
is: Q9H3S5
initial concentration: NaN
name: PIGM
constant: false

metaM xol27oh r
is: CHEBI:17703
constant: false
name: 26-hydroxycholesterol
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial amount: NaN
is: HMDB02103
boundary condition: false
type: Species
initial concentration: 1.0

metaM utp e
type: Species
is: SBO:0000247
boundary condition: false
name: UTP(4-)
is: HMDB00285
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: CHEBI:46398
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_9690b073_4273_4745_9083_764761f1f304
name: DGKG
is encoded by: hsa:1608
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P49619
constant: false
has only substance units: false
type: Species

metaR DM pe hs LPAREN r RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pe_hs[r]
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_33cd91e4_d107_4171_900f_639116a2dff9
name: _C7orf24_1_m
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:C7orf24
constant: false
boundary condition: true

metaR r1604
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR r2358
product: MODEL1310110051#
type: Reaction
fast: false
kinetic law: MODEL1310110051#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110051#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110051#_7f8c7261_fbdc_4b88_8a3f_23f8fc6bcf47
has only substance units: false
is encoded by: hsa:2348
name: FOLR1
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: P15328
boundary condition: true

metaR AG13T14g
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110051#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_f4b97c51_2959_4f67_93c2_651316ecb663
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: A0PJM6
has only substance units: false
boundary condition: true
name: CHKB
is encoded by: hsa:1120

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR r0796
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reversible: true
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110051#

metaR r0122
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is: SBO:0000176
fast: false
kinetic law: MODEL1310110051#
reversible: false

metaM accoa m
has only substance units: false
name: Acetyl-CoA
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
initial amount: NaN
boundary condition: false
constant: false
is: C00024

metaM ksii core4 pre3 g
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: C00130
name: keratan sulfate II biosynthesis, precursor 3
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00175
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_34718b0b_df14_4202_9812_57e132938fc1
is: Q6NVY1
initial concentration: NaN
name: HIBCH
is encoded by: hsa:26275
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaM pchol hs r
name: Phosphatidylcholine
is: SBO:0000247
is: CHEBI:16110
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

metaM ttdca e
is: CHEBI:30807
is: C06424
initial concentration: 1.0
name: tetradecanoate (n-C14:0)
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00806
boundary condition: false
has only substance units: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424

metaR ALAt2r
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000304
modifier: MODEL1310110051#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
name: L-alanine reversible transport via proton symport
product: MODEL1310110051#

metaR FAOXC13C11m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_59116311_5754_41e2_8b99_8a03ca74ab07
type: Species
constant: false
is: Q9NR34
has only substance units: false
initial amount: NaN
name: MAN1C1
is encoded by: hsa:57134
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0236
product: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6
modifier: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110051#
is: SBO:0000176
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1

metaR r0797
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
modifier: MODEL1310110051#
fast: false
reversible: true
product: MODEL1310110051#
type: Reaction
name: glycine N-choloyltransferase EC:2.3.1.65
is: SBO:0000176
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR r1603
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
fast: false
product: MODEL1310110051#
type: Reaction

metaR S6T18g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110051#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110051#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaM dec24dicoa x
boundary condition: false
is: HMDB01168
has only substance units: false
name: 2,4-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM nac c
constant: false
name: Nicotinate
type: Species
is: CHEBI:0
boundary condition: false
is: HMDB01488
is: C00253
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H4NO2 CHARGE: -1
has only substance units: false

metaM CE5119 m
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
constant: false
boundary condition: false
is: CHEBI:57923
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_1bc3b404_5229_4c96_9cb4_0fa5ec79fb45
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A

metaM CE4793 x
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
initial concentration: 1.0
name: 3-oxo-dihomo-gama-linolenoyl-CoA
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793

metaM hexdicoa r
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
has only substance units: false
type: Species
is: C08260
constant: false
boundary condition: false
name: hexadecanedioylcoa
is: SBO:0000247
is: HMDB00672
initial amount: NaN

metaR CHOLPtg
is: SBO:0000185
name: choline phosphate intracellular transport
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
type: Reaction
reversible: true

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_e83cb2f3_f8e8_440f_bb11_b35896426efb
type: Species
initial concentration: NaN
is encoded by: hsa:3419
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: IDH3A
is: SBO:0000252
is: P50213

metaM leu L m
name: L-leucine
type: Species
is: SBO:0000247
is: HMDB00687
has only substance units: false
constant: false
is: CHEBI:15603
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0

metaM utp c
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
name: UTP
is: HMDB00285
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: C00075
is: CHEBI:46398
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_28214fd7_0af2_4027_bf56_47b416422ffb
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10861
type: Species
has only substance units: false
constant: false
name: SLC26A1

metaM accoa g
is: HMDB01206
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
boundary condition: false
is: CHEBI:57288
initial concentration: 1.0
name: acetyl-CoA(4-)

metaR r1602
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110051#

metaM stcoa x
is: CHEBI:57394
initial amount: NaN
constant: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
boundary condition: false
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01114

metaR C102CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR F6Tg
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.68
is: SBO:0000176
reversible: false
modifier: MODEL1310110051#
fast: false
name: glycoprotein 6-alpha-L-fucosyltransferase
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#

metaR ALR3
name: aldose reductase (acetol)
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false

metaM cmpacna g
has only substance units: false
is: CHEBI:57812
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
is: HMDB01176
constant: false

metaR CGLYt3 2
type: Reaction
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
reactant: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
name: Cys-Gly transport in via proton symport
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
reversible: false
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110051#_6b8ee146_9a0e_4945_b775_b16294360e76
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6392
type: Species
initial concentration: NaN
is: O14521
name: SDHD
constant: false

metaR NACHEX13ly
reactant: MODEL1310110051#
is: SBO:0000176
reversible: false
modifier: MODEL1310110051#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM sebacid c
name: sebacicacid
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C08277
notes: FORMULA: C10H16O4 CHARGE: -2
constant: false
is: HMDB00792
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ee0f727b_ab14_4cdb_a515_a2db2cf1c22c
is: SBO:0000252
constant: false
is encoded by: hsa:1635
boundary condition: true
initial concentration: NaN
is: P32321
type: Species
has only substance units: false
initial amount: NaN
name: DCTD

metaR C161CPT22
reactant: MODEL1310110051#
reversible: false
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: C161 transport into the mitochondria
fast: false
product: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

metaR ALR2
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
name: aldose reductase (methylglyoxal)
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110051#

metaR PGLYCt
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: phosphatidylglycerol transport

metaR r1600
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
product: MODEL1310110051#

metaR UGCG
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
kinetic law: MODEL1310110051#
fast: false
name: Ceramide glucosyltransferase
reactant: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.80
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_460dc39d_22f9_4311_b21e_fa9fbffdf6d1
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AI915649
name: _AI915649_1_c
constant: false
boundary condition: true
initial concentration: NaN

metaR RE1807C
name: RE1807
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_615e19cc_4d20_40f8_8b79_0990ccfdc5bf
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3706
constant: false
is: P23677
name: ITPKA
initial amount: NaN
type: Species

metaM prostgi2 e
is: CHEBI:57403
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01335
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
has only substance units: false

metaR S6TASE15ly
reversible: true
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110051#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false

metaR r1824
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
name: Y+LAT2 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_9ad38911_9989_46d4_a99a_7fa304bf09f0
constant: false
name: PECR
is encoded by: hsa:55825
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9BY49

metaM tethex3 e
initial amount: NaN
has only substance units: false
is: HMDB02007
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
constant: false
name: tetracosahexaenoic acid, n-3

metaR r1610
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false

metaR MAL Lte
kinetic law: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
is described by: ECO:0000134
type: Reaction
name: Transport of L-malate
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_3125a1f5_968d_42dc_951c_9f3a8a61ff63
is encoded by: hsa:115019
type: Species
initial concentration: NaN
has only substance units: false
is: Q7LBE3
is: SBO:0000252
initial amount: NaN
name: SLC26A9
constant: false
boundary condition: true

metaM g1p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: CHEBI:58601
is: C00103
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01586
boundary condition: false
name: D-Glucose 1-phosphate
is: SBO:0000247
type: Species

metaM dtdp n
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: SBO:0000247
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01274
type: Species
is: CHEBI:58369
initial concentration: 1.0

metaR r2352
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185

metaM c16dc e
initial concentration: 1.0
name: Hexadecanedioic acid mono-L-carnitine ester
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: HMDB00712
notes: FORMULA: C23H42NO6 CHARGE: -1
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0786962a_5128_4b72_97ae_26dc67448d61
is: SBO:0000252
constant: false
boundary condition: true
is: B7Z1R0
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:57282
name: SLC4A10
initial concentration: NaN

metaR HEXCOAACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_3da0bcc5_4314_4b90_b21b_2300669029e3
constant: false
is: P48200
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3658
type: Species
boundary condition: true
name: IREB2
initial amount: NaN
is: SBO:0000252

metaR r0575
product: MODEL1310110051#
is: SBO:0000176
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000000
type: Reaction

metaR BETALDHxm
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110051#
name: betaine-aldehyde dehydrogenase, mitochondrial
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM

metaR TYRTA
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
name: tyrosine transaminase
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
kinetic law: MODEL1310110051#

metaR GLAl
is version of: http://identifiers.org/ec-code/3.2.1.22
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
type: Reaction
name: galactosidase, alpha
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176

metaR r0789
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110051#

metaM ksii core2 g
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57255
name: keratan sulfate II (core 2-linked)
boundary condition: false
type: Species
has only substance units: false
is: HMDB01014
is: SBO:0000247

metaR r1611
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FAOXC164x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_f61084e8_cf85_48f2_8814_ef683774a7ea
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: CYP7A1
is: P22680
is encoded by: hsa:1581
is: SBO:0000252
has only substance units: false

metaR RDH2a
name: retinol dehydrogenase (9-cis,NADPH)
is: SBO:0000176
product: MODEL1310110051#
fast: false
type: Reaction
modifier: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.105
is version of: http://identifiers.org/ec-code/1.1.1.300
kinetic law: MODEL1310110051#
is described by: ECO:0000269

metaR r0680
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
modifier: MODEL1310110051#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_6c1a0ef0_f554_4d8e_88c5_d465e446b1fe
type: Species
is: Q5QPH3
name: ACSS2
is encoded by: hsa:55902
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaR FOAXC122C101x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_9c7af613_55c9_4c50_9d4d_ed4e1f96403b
is encoded by: hsa:7915
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: ALDH5A1
is: Q546H9

http://identifiers.org/biomodels.db/MODEL1310110051#_c94cef88_982b_491f_9eda_907a08a1d434
name: PIP5K1A
has only substance units: false
is encoded by: hsa:8394
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: Q99755
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_a6cbc158_7456_4918_a946_c71608cdcbdc
has only substance units: false
constant: false
is encoded by: hsa:10786
is: O00476
boundary condition: true
type: Species
name: SLC17A3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR r0683
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#

metaR r1109
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
type: Reaction
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_42e44ca7_b0ba_4de6_9868_a16a57b70308
name: ITPKC
is: SBO:0000252
initial concentration: NaN
is: Q96DU7
is encoded by: hsa:80271
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR r0578
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.1.2.27
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
product: MODEL1310110051#

metaR r1717
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000185
reversible: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110051#
is described by: ECO:0000000

metaR r0340
fast: false
kinetic law: MODEL1310110051#
type: Reaction
reversible: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_ffc41eb4_fb56_4bb0_ab78_65a09efa7bd5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6120
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: RPE
is: Q96AT9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_401e40ad_edad_4ce4_8289_bb079bb96060
constant: false
has only substance units: false
initial concentration: NaN
name: _AW277253_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:AW277253
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_7bccf1c7_b255_4193_a740_ebc2f5203e7b
initial amount: NaN
type: Species
is: B1AM93
is: SBO:0000252
constant: false
is encoded by: hsa:4702
boundary condition: true
name: NDUFA8
has only substance units: false
initial concentration: NaN

metaM adpac x
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00448
initial concentration: 1.0
boundary condition: false
name: adipic acid
notes: FORMULA: C6H8O4 CHARGE: -2
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c9c3cb80_7d84_445e_932b_1002221e86b9
initial concentration: NaN
is encoded by: hsa:8525
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: DGKZ
constant: false
is: SBO:0000252
is: B7Z6M3

http://identifiers.org/biomodels.db/MODEL1310110051#_948a6c2e_8141_4033_ba15_6104f26523cd
boundary condition: true
constant: false
is: O43924
is encoded by: hsa:5147
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PDE6D
type: Species

metaM arachcoa c
is: CHEBI:15527
has only substance units: false
initial concentration: 1.0
constant: false
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB04258

metaR PE HStm
product: MODEL1310110051#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylethanolamine scramblase
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_d3546087_8691_43f2_b327_31d62b8dc8df
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: ALDH1B1
is: P30837
is encoded by: hsa:219
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d6021de0_c937_4472_8707_caa2a43e1fb4
is: SBO:0000252
constant: false
has only substance units: false
is: O15270
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9517
initial amount: NaN
name: SPTLC2

metaR FAOXC161C141x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_89164739_f1a9_41b8_8383_4b7fdefe9c54
constant: false
has only substance units: false
name: CYP27A1
boundary condition: true
is encoded by: hsa:1593
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q02318

metaM 2mpdhl m
is: SBO:0000247
is: CHEBI:17577
constant: false
initial amount: NaN
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide

metaM ksii core2 e
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:17268
is: HMDB00211

http://identifiers.org/biomodels.db/MODEL1310110051#_d465c944_814c_44e8_81f7_d5cf0ad37c33
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: B2RB13
has only substance units: false
constant: false
name: ACSL6
is encoded by: hsa:23305

metaR FAOXC163GC142m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM pmtcoa r
has only substance units: false
is: HMDB01338
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
constant: false
boundary condition: false
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: SBO:0000247
is: C00154
initial amount: NaN

metaM prostge1 c
constant: false
is: CHEBI:57397
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: HMDB01442
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR OCD11COACPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM hestratriol r
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 4,17 dihydroxy estradiol
has only substance units: false
constant: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: HMDB05896
initial amount: NaN
type: Species

metaR FAOXC122m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM ttdca c
name: myristate
type: Species
is: HMDB00806
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
constant: false
is: CHEBI:30807
initial amount: NaN

metaM dtdp m
boundary condition: false
name: dTDP
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: C00363
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01274
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_4c845da4_0f96_4fa0_9045_3362d16237af
is encoded by: hsa:6697
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: P35270
name: SPR
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2d9836b1_8b6d_4e08_b89b_b8292935aa31
constant: false
is encoded by: hsa:5277
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5279
is encoded by: hsa:51227
is: SBO:0000297
has only substance units: false
initial concentration: NaN
has part: P57054
type: Species
is encoded by: hsa:9091
has part: B2RAU6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_df08b813_465f_4329_9306_2cb44cb4952f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54363
name: HAO1
initial amount: NaN
constant: false
is: Q9UJM8
has only substance units: false
type: Species
boundary condition: true

metaR PAIL45P HStn
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR BPNT
reversible: false
is described by: ECO:0000269
name: 3',5'-bisphosphate nucleotidase
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.3.7
fast: false
reactant: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
type: Reaction
modifier: MODEL1310110051#

metaM hista c
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: histamium
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58432
has only substance units: false
is: HMDB00870

metaM sbcoa c
is: HMDB00791
has only substance units: false
name: suberylcoa
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: C02838
type: Species
initial concentration: 1.0

metaR r2356
reversible: true
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110051#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110051#
fast: false

metaM sgalside hs c
is: HMDB03406
is: CHEBI:16523
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_38988f1d_1478_4be6_9686_7fa89fb41cee
is encoded by: hsa:3422
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q13907
name: IDI1

http://identifiers.org/biomodels.db/MODEL1310110051#_5bf800a5_bf92_4e8e_9697_cad34ca1390d
boundary condition: true
is encoded by: hsa:2618
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: Q59HH3
has only substance units: false
type: Species
name: GART

metaR THCHOLSTOICtm
name: lipid, flip-flop intracellular transport
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR RE1342C
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
reversible: true
is: SBO:0000176
name: RE1342
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR G14T8g
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110051#
type: Reaction
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM ditp c
name: dITP(4-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03537
initial amount: NaN
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a7be10f3_8277_48ab_b3a1_4b8c39b9fcd5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:D87002
boundary condition: true
initial amount: NaN
constant: false
name: _D87002_1_e

metaR GGH 7THFe
reactant: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110051#
name: Gamma-glutamyl hydrolase (7THF), extracellular
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_a827226e_030e_4103_a642_8e9491cf3a0b
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: GALNT12
is: Q8IXK2
is encoded by: hsa:79695
type: Species

metaM retn e
name: all-trans-retinoate
constant: false
is: CHEBI:35291
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01852
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false

metaR DOLPMT3 Ler
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
fast: false
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.260

metaR r0579
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
is version of: http://identifiers.org/ec-code/1.13.11.19
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176

metaR FAOXC181C181OHm
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR FAOXC7C5m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaR FCOAH
is described by: ECO:0000000
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: formyl coa hydrolase
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_36a1b0cb_cd20_4367_9446_5e84e48eb584
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6513
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: P11166
is: SBO:0000252
name: SLC2A1

metaM ade c
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16708
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00034
is: C00147
is: SBO:0000247
name: Adenine

metaR RE2426C
is: SBO:0000176
reversible: true
name: RE2426
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:

metaR r2355
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110051#
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR PTDCACRNCPT2
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110051#
name: pentadecanoate transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110051#_31b5db74_d443_4161_ac2f_daaa2ba1b58c
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:159963
is: Q1EHB4
name: SLC5A12
constant: false
boundary condition: true

metaR RE2659R
product: MODEL1310110051#
is described by: ECO:0000000
name: RE2659
kinetic law: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
reversible: true

metaR DOLPMT3 Uer
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: false

metaM tethex3 c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: tetracosahexaenoic acid, n-3
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
is: SBO:0000247
is: HMDB02007
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_3a3d506e_3ff7_442d_80d8_77a8a0469a32
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false

metaR r2354
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110051#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
reversible: true

metaM prostgi2 c
name: prostaglandin I2(1-)
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
boundary condition: false
is: HMDB01335
is: CHEBI:57403

metaM CE4792 m
boundary condition: false
initial concentration: 1.0
name: 3-oxo-cis-8-tetradecenoyl-CoA
initial amount: NaN
is: CHEBI:57923
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaM hista e
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: histamium
is: SBO:0000247
is: HMDB00870
is: CHEBI:58432

http://identifiers.org/biomodels.db/MODEL1310110051#_a1edcfdd_3f82_4137_bf66_415dab2096df
has only substance units: false
is: P04062
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2629
constant: false
name: GBA
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_141141f8_f38a_429b_9f60_64a17a51aeb8
initial amount: NaN
constant: false
is encoded by: hsa:8309
type: Species
initial concentration: NaN
is: Q99424
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ACOX2

metaR FAOXC102C103m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM retn c
name: all-trans-retinoate
constant: false
is: CHEBI:35291
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM arg L m
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:32682
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
name: L-argininium(1+)

metaR r0456
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.32
fast: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#

metaR DINt
name: deoxyinosine transport via diffusion
reactant: MODEL1310110051#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000000

metaR MCCCrm
is version of: http://identifiers.org/ec-code/6.4.1.4
fast: false
product: MODEL1310110051#
name: methylcrotonoyl-CoA carboxylase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reversible: true
is: SBO:0000176
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaR r2353
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110051#

metaR Asn X Ser Thrtr
name: Asn-X-Ser/Thr transport (from ER to lysosome)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
product: MODEL1310110051#

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR r1930
kinetic law: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction

metaM bildglcur e
has only substance units: false
is: HMDB03325
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
constant: false
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_40d9a0ab_b14d_4de2_8d84_149407a22329
type: Species
is encoded by: hsa:113026
has only substance units: false
boundary condition: true
is: Q8N3E9
constant: false
initial concentration: NaN
is: SBO:0000252
name: PLCD3
initial amount: NaN

metaR FAOXC103C102x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaM ksii core2 pre4 g
type: Species
is: C00130
boundary condition: false
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: HMDB00175
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 4

http://identifiers.org/biomodels.db/MODEL1310110051#_852679a2_806e_4683_a067_cdf351e3d1f3
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:NOS2A
type: Species
has only substance units: false
initial concentration: NaN
name: _NOS2A_1_e
constant: false

metaR S6T3g
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110051#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
fast: false
reversible: false

metaM crvnc e
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:36005
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C22H31O2 CHARGE: -1
constant: false
is: SBO:0000247
is: HMDB02183
name: cervonic acid, C22:6 n-3

http://identifiers.org/biomodels.db/MODEL1310110051#_7082a1e1_9ef9_4159_b0d1_6d7035091d06
initial amount: NaN
is: Q9P0Z9
is encoded by: hsa:51268
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PIPOX

http://identifiers.org/biomodels.db/MODEL1310110051#_e7a07825_7c58_4d98_b0f2_7f63d652550b
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: ACAA1
is: Q96CA6
is encoded by: hsa:30
initial amount: NaN
boundary condition: true

metaR AKR1D2
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000176
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.1.3
product: MODEL1310110051#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

metaM citr L c
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16349
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: L-citrulline
has only substance units: false
is: SBO:0000247
is: HMDB00904
constant: false

metaR CITL
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reversible: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Citrate lyase
type: Reaction

metaR ADRNCPT2
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
name: carnitine transferase
kinetic law: MODEL1310110051#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_d2253bf8_7528_47cd_af72_40fd00bcf2f8
boundary condition: true
is encoded by: hsa:216
name: ALDH1A1
is: P00352
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR CERT2gt
product: MODEL1310110051#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

metaR 4HGLSDm
reactant: MODEL1310110051#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000212
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_9572542d_9551_4086_91a1_198c8cfeff12
boundary condition: true
is: O00330
is encoded by: hsa:8050
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: PDHX
has only substance units: false
initial amount: NaN

metaM pmtcoa x
has only substance units: false
boundary condition: false
is: C00154
initial concentration: 1.0
is: CHEBI:57379
is: HMDB01338
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)

metaR r0688
kinetic law: MODEL1310110051#
fast: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
product: MODEL1310110051#
modifier: MODEL1310110051#

metaR STRDNCCRNt
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110051#
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#

metaR r0345
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2e7241e1_e152_4df6_a0dd_6f42f16774a3
name: PPA2
has only substance units: false
boundary condition: true
is: Q9H2U2
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:27068
constant: false

metaR Q10H2e
reversible: true
reactant: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000134
is: SBO:0000185
name: transport of ubiquinol into lymph
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

metaM HC00342 m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
type: Species
name: cis-aconitate(3-)
constant: false
is: CHEBI:16383
has only substance units: false

metaR r0450
reversible: true
modifier: MODEL1310110051#
fast: false
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110051#

metaR PPCDC
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
name: phosphopantothenoylcysteine decarboxylase
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_1c44199c_2066_45c8_8175_24b147c69e91
initial concentration: NaN
type: Species
is: Q3MHC9
boundary condition: true
has only substance units: false
is encoded by: hsa:23517
constant: false
name: SKIV2L2
initial amount: NaN
is: SBO:0000252

metaR PTDCACRNCPT1
name: carnitine fatty-acyl transferase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false

metaM crvnc c
has only substance units: false
notes: FORMULA: C22H31O2 CHARGE: -1
initial concentration: 1.0
is: CHEBI:36005
constant: false
initial amount: NaN
is: SBO:0000247
name: cervonic acid, C22:6 n-3
is: HMDB02183
boundary condition: false
type: Species

metaM citr L e
boundary condition: false
is: CHEBI:16349
name: citr_L[e]
initial concentration: 1.0
is: SBO:0000247
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM ipdp x
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
boundary condition: false
name: isopentenyl diphosphate(3-)
is: HMDB01347
initial amount: NaN
type: Species
is: CHEBI:128769
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2ebe1e52_33ec_46a2_b346_7709d3e198c7
has only substance units: false
is: C9JC79
initial concentration: NaN
constant: false
name: SCP2
initial amount: NaN
is encoded by: hsa:6342
type: Species
is: SBO:0000252
boundary condition: true

metaM CE5101 m
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
boundary condition: false
is: CHEBI:57795
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_0e63e92e_4e91_4e32_a7c6_47db9aaba460
name: PPA2
is: F8WDN9
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:27068
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_f85cba9f_e573_4f19_84af_d21cb9898237
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: DECR1
boundary condition: true
constant: false
type: Species
is: Q16698
is encoded by: hsa:1666

metaR r0570
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
product: MODEL1310110051#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
reversible: true
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.3.2
is: SBO:0000176
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#

metaR GALASE3ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR RE1517M
modifier: MODEL1310110051#
name: RE1517
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR FAOXC101C8x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaR FAOXC160
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
fast: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
reversible: false

metaR OLEICFATPtc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR FAOXC103C102m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR 13DAMPPOX
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000212
is: SBO:0000176
kinetic law: MODEL1310110051#
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22

metaR CLPNDt
fast: false
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110051#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_8c41b01b_15e5_4683_b8af_4a49aeab7a1e
type: Species
name: ESPN
has only substance units: false
boundary condition: true
is encoded by: hsa:83715
initial concentration: NaN
is: SBO:0000252
constant: false
is: B1AK53
initial amount: NaN

metaM g1m8mpdol L r
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C05870
type: Species
constant: false
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
initial amount: NaN
initial concentration: 1.0
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR ACNAMlt
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is: SBO:0000185
reversible: true
type: Reaction
name: N-acetylneuraminate transport into lysososme
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110051#_4018c7b0_6b02_404a_8ff0_821565610f96
initial concentration: NaN
is: P00915
boundary condition: true
is: SBO:0000252
has only substance units: false
name: CA1
constant: false
is encoded by: hsa:759
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_b217ec43_7e9d_45ea_863d_e4bbf18c412d
type: Species
initial concentration: NaN
is encoded by: hsa:35
has only substance units: false
is: SBO:0000252
name: ACADS
constant: false
initial amount: NaN
boundary condition: true
is: P16219

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaM prist x
boundary condition: false
name: pristanic acid
type: Species
is: HMDB00795
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:51340
initial amount: NaN
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)

http://identifiers.org/biomodels.db/MODEL1310110051#_570d470f_257d_4683_a9f0_0ea9ee55300d
is encoded by: hsa:D87002
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _D87002_1_m
is: SBO:0000252
type: Species
initial amount: NaN

metaM ppcoa c
constant: false
is: C00100
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57392
name: Propanoyl-CoA
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
initial amount: NaN

metaM sebacid x
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: sebacicacid
constant: false
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2
is: C08277
boundary condition: false
has only substance units: false

metaM oxa c
is: CHEBI:30623
is: HMDB02329
is: SBO:0000247
name: oxalate(2-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaM bildglcur r
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
is: HMDB03325
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

metaR FAOXC164m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR THRCYSNaEx
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
is: SBO:0000185
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269

metaM glx x
constant: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
boundary condition: false
is: CHEBI:36655
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: glyoxylate

metaM accoa x
is: SBO:0000247
type: Species
is: C00024
is: CHEBI:57288
has only substance units: false
constant: false
name: Acetyl-CoA
is: HMDB01206
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN

metaR CYSGLNNaEx
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110051#
type: Reaction
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269

metaR r0899
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110051#
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction

metaM ksii core2 l
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked)
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:57255
is: HMDB01014
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_2da67bae_b50f_4d19_a851_dfda315d31e9
name: GGT1
initial amount: NaN
is: P19440
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:2678
type: Species
boundary condition: true

metaM Lcystin c
boundary condition: false
is: CHEBI:16283
initial amount: NaN
type: Species
constant: false
name: L-cystine
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_0feb42f9_9b2c_4184_b6b2_ab4d82a82dc2
initial amount: NaN
boundary condition: true
is: Q9NQR4
is: SBO:0000252
is encoded by: hsa:56954
initial concentration: NaN
type: Species
constant: false
name: NIT2
has only substance units: false

metaR r1715
type: Reaction
is: SBO:0000185
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110051#
fast: false
name: Y+LAT2 Utilized transport

metaR PRPPS
is: SBO:0000176
product: MODEL1310110051#
name: phosphoribosylpyrophosphate synthetase
reactant: MODEL1310110051#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.6.1
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaR HS4ly
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
type: Reaction
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110051#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_96463c56_d683_4583_8948_b68baab83366
boundary condition: true
constant: false
type: Species
is encoded by: hsa:U52111
has only substance units: false
name: _U52111_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_c49bf5a7_3b0c_4ef2_ba2b_72bd0c30d540
has part: Q9P0J0
has part: O00483
is encoded by: hsa:55967
is encoded by: hsa:4719
is encoded by: hsa:4728
has part: E5KNH5
is encoded by: hsa:4696
is encoded by: hsa:4715
is encoded by: hsa:4707
is encoded by: hsa:4537
has part: O95299
is encoded by: hsa:4725
has part: F8VQS7
is encoded by: hsa:4713
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q6IBA0
has part: P03905
is encoded by: hsa:4723
initial amount: NaN
has part: O95139
has only substance units: false
is encoded by: hsa:4711
has part: B1AM93
is encoded by: hsa:4720
has part: P03915
has part: Q6IBB5
has part: Q6FG42
has part: Q549M5
type: Species
is encoded by: hsa:4709
is encoded by: hsa:4539
is encoded by: hsa:4698
has part: B7Z792
is encoded by: hsa:4718
boundary condition: true
is encoded by: hsa:7991
has part: Q13454
is encoded by: hsa:4705
is encoded by: hsa:4695
has part: P56181
has part: O95168
is encoded by: hsa:4536
is encoded by: hsa:4706
has part: Q7GXZ4
is encoded by: hsa:4541
is encoded by: hsa:4724
has part: O75251
initial concentration: NaN
has part: O95167
has part: H7C5B8
is encoded by: hsa:4722
has part: P28331
is encoded by: hsa:4731
has part: A8K761
has part: P19404
has part: P56556
is encoded by: hsa:4701
has part: P17568
is encoded by: hsa:4710
is encoded by: hsa:4540
has part: O75489
is encoded by: hsa:374291
is encoded by: hsa:4729
has part: Q16718
is encoded by: hsa:4697
is encoded by: hsa:4716
has part: O95169
has part: O43674
is encoded by: hsa:4708
is encoded by: hsa:4538
has part: O43677
is encoded by: hsa:4717
has part: Q7GXZ1
is encoded by: hsa:4726
is encoded by: hsa:4704
is encoded by: hsa:4694
is encoded by: hsa:126328
is encoded by: hsa:4535
has part: P03897
has part: Q9Y6M9

metaR DATPtn
reactant: MODEL1310110051#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: dATP diffusion in nucleus
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_7a46f460_cb38_41e6_a77b_585f0f779114
is: SBO:0000252
is: P26572
initial amount: NaN
name: MGAT1
boundary condition: true
is encoded by: hsa:4245
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d35b92e0_223b_46a4_b0cb_2353ac32099b
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6391
is: SBO:0000252
is: Q99643
boundary condition: true
initial amount: NaN
name: SDHC
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2461335a_67a6_45a1_9437_8c592e27b00b
constant: false
is: E7ET30
name: AK3
is encoded by: hsa:50808
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR SERPT
kinetic law: MODEL1310110051#
reversible: false
is described by: ECO:0000269
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.50
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
name: serine C-palmitoyltransferase

metaM nicrns c
has only substance units: false
initial concentration: 1.0
name: Nicotinate D-ribonucleoside
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
is: CHEBI:58527
is: HMDB06809

http://identifiers.org/biomodels.db/MODEL1310110051#_e6fc389e_fa34_4ecf_84c5_49f469fe0d7b
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:23530
initial amount: NaN
has only substance units: false
name: NNT

metaM c16dc c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H42NO6 CHARGE: -1
initial concentration: 1.0
is: HMDB00712
constant: false
name: Hexadecanedioic acid mono-L-carnitine ester
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_2f34ff51_8ea9_44a5_a283_16551874efa9
initial concentration: NaN
is encoded by: hsa:10331
boundary condition: true
initial amount: NaN
type: Species
is: Q9Y2A9
is: SBO:0000252
has only substance units: false
constant: false
name: B3GNT3

metaR FK
is described by: ECO:0000000
name: Fucokinase
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.52
is: SBO:0000176
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_530711bd_4099_456c_889e_0df802b636f0
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5169
is: SBO:0000252
is: Q308M7
name: ENPP3
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_f334790c_7749_41c1_b7a0_4a2405db8fba
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: P42765
is: SBO:0000252
name: ACAA2
boundary condition: true
is encoded by: hsa:10449
initial amount: NaN

metaR H8TAer
is: SBO:0000176
reversible: false
fast: false
name: H8 transamidase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
modifier: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000

metaM Lcystin e
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
is: SBO:0000247
is: HMDB00192
has only substance units: false
boundary condition: false
is: CHEBI:16283
initial amount: NaN
type: Species
constant: false

metaR ACOAD8m
reversible: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.10
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial

metaM gar c
is: SBO:0000247
constant: false
is: HMDB02022
is: C03838
boundary condition: false
type: Species
initial amount: NaN
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
has only substance units: false
initial concentration: 1.0

metaR C10DCCACT
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR r1826
modifier: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110051#
fast: false

metaM ksi deg5 l
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate I, degradation product 5
constant: false
initial amount: NaN
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: CHEBI:12936

metaR PSSA2 hs
type: Reaction
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
is version of: http://identifiers.org/ec-code/2.7.8.29
fast: false
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: Phosphatidylserine synthase homo sapiens
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_b08e6643_c72f_447e_803c_e8d75079a6a1
constant: false
name: COX5B
initial amount: NaN
is: Q53YB7
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:1329
initial concentration: NaN
has only substance units: false

metaM c6dc c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: adipoyl carnitine
has only substance units: false
constant: false
is: HMDB00705
is: SBO:0000247
notes: FORMULA: C13H22NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110051#_ef79626d_0b3a_4710_bc4a_e4deb4c125a0
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:374907
type: Species
constant: false
name: B3GNT8

metaR Rtotaltl
fast: false
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
name: fatty acid intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
reactant: MODEL1310110051#
is described by: ECO:0000000

metaR r1106
reactant: MODEL1310110051#
type: Reaction
fast: false
name: Postulated transport reaction
is: SBO:0000185
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110051#

metaR LTD4DP
name: Leukotriene D4 dipeptidase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c683300d_a8a8_49a8_aaab_7da949c1e5c1
name: NDUFB1
constant: false
initial amount: NaN
boundary condition: true
is: O75438
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4707

metaR FTHFL
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
name: Formate-tetrahydrofolate ligase
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.5.1.5
modifier: MODEL1310110051#
product: MODEL1310110051#
reversible: true
is described by: ECO:0000134

metaR r0686
kinetic law: MODEL1310110051#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
product: MODEL1310110051#

metaR PA HSter
type: Reaction
fast: false
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000000
name: phosphatidate scramblase
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
product: MODEL1310110051#
is: SBO:0000185

metaM Rtotal3coa c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: CHEBI:16189
initial amount: NaN
has only substance units: false
name: R total 3 Coenzyme A
is: SBO:0000247
type: Species
is: HMDB01448
constant: false

metaR RE3270C
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
reversible: true
name: RE3270
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_5dd7b9b1_1d78_4655_b938_35bcb0935f58
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3028
is: Q99714
name: HSD17B10
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR C4tmc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_24413ee3_8a70_4746_b70e_f009e98ca960
is: SBO:0000252
is: Q13370
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:5140
name: PDE3B

metaM g3m8masn r
type: Species
is: C05873
boundary condition: false
is: SBO:0000247
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
constant: false
initial amount: NaN

metaR PPCOACm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.3
reversible: false
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
reactant: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
name: Propionyl-CoA carboxylase, mitochondrial
kinetic law: MODEL1310110051#

metaR r1020
name: Postulated transport reaction
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_b8972d0e_0365_40ce_b38d_6dbd8680a0d7
is: E9KL42
initial concentration: NaN
name: ACOT1
has only substance units: false
constant: false
is encoded by: hsa:641371
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: NICRNS
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110051#

metaM orot e
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
name: orotate
initial concentration: 1.0
is: CHEBI:30839
is: HMDB00226
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

metaM strdnccrn m
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB06463
is: SBO:0000247
boundary condition: false
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
initial concentration: 1.0
name: stearidonyl carnitine

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR RE3004M
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110051#
modifier: MODEL1310110051#
name: RE3004

metaR XOL7AH2tm
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110051#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_cbc45ef9_3641_46fb_a1d4_e773c0f0959f
has only substance units: false
type: Species
is encoded by: hsa:84532
initial amount: NaN
is: Q9NUB1
name: ACSS1
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r2521
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000185
name: Utilized transport
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
fast: false

metaR OMHPALTD
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaR PSP L
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.3
name: phosphoserine phosphatase (L-serine)
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
reactant: MODEL1310110051#

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaR HOCTDECCRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaR HPYRDC
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
fast: false
name: hydroxypyruvate decarboxylase
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_282d9d6d_8179_442c_b012_a0eb418e0d5d
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: TMEM91
has only substance units: false
is: C9JZ62
is encoded by: hsa:641649

metaR FAOXC164C163x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaR AG13T17g
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110051#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_547de362_e6b4_4876_9411_cea84a56f017
is: Q16773
initial concentration: NaN
type: Species
initial amount: NaN
name: CCBL1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:883
is: SBO:0000252

metaR r2520
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
product: MODEL1310110051#

metaR RE2972M
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.67
product: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: RE2972
reversible: true
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_fdfb89f2_8e93_48f7_bb41_5a17d2449180
is: Q9UKG4
initial concentration: NaN
is encoded by: hsa:26266
name: SLC13A4
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b4d21878_d2e2_4776_b1b3_edd81925bf7c
name: PANK3
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79646
is: Q9H999
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR RE1836X
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: RE1836
modifier: MODEL1310110051#
type: Reaction

metaR ENGASEly
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
is: SBO:0000176
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reversible: false

metaM orot c
name: Orotate
boundary condition: false
is: CHEBI:30839
is: HMDB00226
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00295
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

metaR DHCRD2
fast: false
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110051#
is: SBO:0000176
name: dihydroceramide desaturase

metaR FAOXC200180m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110051#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reversible: false
product: MODEL1310110051#
reactant: MODEL1310110051#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110051#_a2a61ad2_114e_4e3d_94eb_f9dbc1d03089
initial concentration: NaN
name: AOC3
initial amount: NaN
type: Species
is encoded by: hsa:8639
boundary condition: true
is: SBO:0000252
is: Q16853
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ee4031a8_9b78_47a8_86c2_7030c46a8e0f
is: SBO:0000252
boundary condition: true
name: ATP10A
has only substance units: false
is encoded by: hsa:57194
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: O60312

metaR r0224
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
reversible: false
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is: SBO:0000176

metaM lnlccrn m
is: HMDB06469
constant: false
type: Species
name: Linoleyl carnitine
has only substance units: false
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM m2emgacpail hs r
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: C00080
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM amp x
boundary condition: false
constant: false
name: AMP
initial amount: NaN
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
is: HMDB00045
has only substance units: false
is: SBO:0000247
is: CHEBI:456215
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_92e1c485_5c09_4ac3_9be3_49706b376806
is: Q8NCI4
name: PIGG
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54872
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR ILEtec
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110051#
is described by: ECO:0000269
fast: false
name: L-isoleucine transport via diffusion (extracellular to cytosol)
type: Reaction
kinetic law: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185

metaR MTHFCm
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.4.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR GUACYC
reversible: false
name: guanylate cyclase
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/4.6.1.2

http://identifiers.org/biomodels.db/MODEL1310110051#_fcd563b7_3be2_4fd7_ae0e_93f8089d0af5
initial amount: NaN
constant: false
is: P34949
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: MPI
is encoded by: hsa:4351
boundary condition: true

metaR PFK26
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: 6-phosphofructo-2-kinase
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
modifier: MODEL1310110051#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.105
type: Reaction

metaR C10DCc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaM 3hpcoa m
has only substance units: false
name: 3-hydroxypropanoyl-CoA(4-)
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial amount: NaN
type: Species
is: CHEBI:58528
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06807

metaM 3ddcrn e
constant: false
is: HMDB00791
type: Species
notes: FORMULA: C19H37NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C02838
boundary condition: false
name: 3-hydroxydodecanoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110051#_e2589056_3afa_4aae_a146_cee7027ab5ce
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110051#_08c0cba9_183c_48ed_a081_dcadd1e741a0
is: SBO:0000252
has only substance units: false
is encoded by: hsa:28976
type: Species
is: Q9H845
initial concentration: NaN
name: ACAD9
constant: false
boundary condition: true
initial amount: NaN

metaM 4hpro LT m
is: HMDB00725
initial amount: NaN
is: SBO:0000247
is: CHEBI:18095
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
constant: false
name: trans-4-hydroxy-L-proline

metaR AMPtp
reactant: MODEL1310110051#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
name: AMP transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ

metaR 3MOX4HOXPGALDOX
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000304
is: SBO:0000176
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110051#
type: Reaction
fast: false
reactant: MODEL1310110051#

metaM fprica c
initial amount: NaN
constant: false
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
is: CHEBI:58467
is: C04734
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
initial concentration: 1.0
type: Species
is: HMDB01439
has only substance units: false
is: SBO:0000247

metaR ALCD21 D
kinetic law: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000304
fast: false
is: SBO:0000176
name: alcohol dehydrogenase (D-1,2-propanediol)
type: Reaction
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.1

metaR LPS3
is version of: http://identifiers.org/ec-code/3.1.1.23
is: SBO:0000176
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: lipase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
fast: false
reactant: MODEL1310110051#
reversible: false

metaR FAOXC10C10OHm
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaR P5CRm
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
name: pyrroline-5-carboxylate reductase (m)
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110051#
fast: false

metaM ade e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00034
type: Species
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
name: adenine
is: CHEBI:16708
initial amount: NaN
constant: false

metaM 4hglusa m
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
initial amount: NaN
has only substance units: false
is: CHEBI:27809
constant: false
is: SBO:0000247
initial concentration: 1.0
name: L-4-hydroxyglutamic semialdehyde
boundary condition: false
type: Species
is: HMDB06556

metaR HISD
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/4.3.1.3
name: histidase
fast: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#

metaR RE1135C
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
name: RE1135

metaR SERDGLNexR
fast: false
modifier: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
is described by: ECO:0000304
name: D-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110051#
is: SBO:0000185
reversible: true

metaM tymsf c
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB06409
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: Tyramine O-sulfate

metaR DOLGLCP Lter
type: Reaction
fast: false
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
product: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_65a0c5b6_cf55_47ba_bd1f_4778cdbf1d62
is encoded by: hsa:9435
is: SBO:0000252
name: CHST2
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9Y4C5
has only substance units: false
constant: false
boundary condition: true

metaM dha e
initial concentration: 1.0
has only substance units: false
name: glycerone
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01882
is: CHEBI:16016
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
boundary condition: false

metaR LNLNCAt
is: SBO:0000185
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_f9b2cc51_3174_4e8c_8741_28ef97e36a61
type: Species
is encoded by: hsa:6818
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q1ET61
initial amount: NaN
name: SULT1A3
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_d33370b3_2a09_49ca_80d5_d0a33e317f96
type: Species
has only substance units: false
is encoded by: hsa:6528
name: SLC5A5
initial concentration: NaN
constant: false
is: Q92911
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM acgam1p c
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: SBO:0000247
has only substance units: false
is: HMDB01367
type: Species
initial concentration: 1.0
name: N-Acetyl-D-glucosamine 1-phosphate
is: CHEBI:7125
constant: false
boundary condition: false

metaR LGNCt
reversible: true
name: fatty acid transport via diffusion
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
product: MODEL1310110051#
is: SBO:0000185
type: Reaction

metaR 4MOPte
name: Transport of 4-methyl-2-oxopentanoate
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaM amet m
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00019
is: HMDB01185
is: CHEBI:15414
name: S-Adenosyl-L-methionine
has only substance units: false
boundary condition: false

metaM HC00361 c
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58335
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
name: sedoheptulose 1,7-bisphosphate(4-)

http://identifiers.org/biomodels.db/MODEL1310110051#_844f8763_327b_4db8_a9ad_0624d5a81a4d
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _MBOAT5_1_c
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:MBOAT5

metaR ACALDt
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
name: acetaldehyde reversible transport

metaM cs e deg4 l
initial amount: NaN
notes: FORMULA: C31H46NO38S4 CHARGE: -5
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
has only substance units: false
is: HMDB00127
boundary condition: false
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

metaM CE2416 x
name: (2R,6S,10S)-pristanate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
constant: false
is: CHEBI:57923
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR GPIAT
name: glucosaminylphosphatidyl inositol acetyltransferase
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110051#_9f5b4580_36ba_42b8_b65d_0d55e5647ddf
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:10654
name: PMVK
constant: false
is: Q6FGV9

metaM g3m8mpdol L r
type: Species
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
is: CHEBI:37568
is: C00459
is: HMDB01342
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_ae30a7cb_159c_492c_86bb_ec798e20a9bf
constant: false
is: SBO:0000252
has only substance units: false
name: ALAS1
boundary condition: true
type: Species
initial concentration: NaN
is: P13196
initial amount: NaN
is encoded by: hsa:211

metaR PROSTGE2t
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110051#
fast: false
reversible: true
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#

metaR RE1525M
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110051#
fast: false
name: RE1525
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_f237adaa_84a3_4af6_b84f_b8597a103baf
constant: false
type: Species
initial amount: NaN
is: A0S0A7
name: NOS3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4846
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_7f359de1_0b52_4230_a241_34d0d4fa6c5e
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:114134
has only substance units: false
type: Species
is: Q96QE2
name: SLC2A13
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_c252fc5c_5d0e_44aa_b8f7_a48d0da963fc
name: _AI926493_1_m
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI926493
type: Species
constant: false

metaM ksi pre25 g
is: C00130
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 25
boundary condition: false
type: Species

metaR MACACI
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110051#
reversible: false
name: maleylacetoacetate isomerase
is: SBO:0000176

metaM amet c
constant: false
name: S-Adenosyl-L-methionine
is: CHEBI:15414
initial concentration: 1.0
type: Species
is: HMDB01185
has only substance units: false
is: C00019
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

metaR GALASE17ly
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
product: MODEL1310110051#
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR r0647
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
name: Spontaneous reaction
is described by: ECO:0000000
reversible: true

metaR SBCOAACOTx
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaM lnlccrn c
is: HMDB06469
initial concentration: 1.0
initial amount: NaN
name: Linoleyl carnitine
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247

metaM HC02213 e
type: Species
constant: false
name: prostaglandin-e3
initial amount: NaN
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR FATP3t
name: fatty acid electroneutral transport
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
reversible: true

metaR ADK1m
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
name: adenylate kinase, mitochondrial
modifier: MODEL1310110051#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3

metaM ctp m
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
constant: false
is: CHEBI:37563
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00082

metaR NTD5m
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
reversible: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
name: 5'-nucleotidase (dTMP), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110051#_e039b035_76e0_4927_8002_43c4c27cdbe1
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI631997
name: _AI631997_1_m
initial concentration: NaN

metaM acmana e
has only substance units: false
type: Species
name: N-acetyl-D-mannosamine
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01129
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
initial concentration: 1.0
is: CHEBI:17122

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM 3ddcrn c
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C19H37NO5 CHARGE: 0
has only substance units: false
name: 3-hydroxydodecanoylcarnitine
is: HMDB00623

http://identifiers.org/biomodels.db/MODEL1310110051#_64d189ac_d6cf_43a8_b20d_0580b7b363cb
is encoded by: hsa:6390
has part: P21912
is encoded by: hsa:6391
name: SDHA:SDHB:SDHC:SDHD
initial concentration: NaN
is: SBO:0000297
has part: O14521
has part: Q99643
is encoded by: hsa:6392
is encoded by: hsa:6389
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
has part: P31040
type: Species

metaR C162ACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaM bilglcur c
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:57767
type: Species

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR GAL3ST11
product: MODEL1310110051#
reactant: MODEL1310110051#
name: Galactosylceramide sulfotransferase
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
modifier: MODEL1310110051#
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.8.2.11
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2b32f04d_1d7c_4fc5_871b_95d3f3d115d8
initial amount: NaN
boundary condition: true
constant: false
is: E7ET32
name: GALT
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2592

metaM ach n
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00895
type: Species
has only substance units: false
is: CHEBI:15355
name: acetylcholine

metaM cytd c
is: C00475
type: Species
boundary condition: false
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247
has only substance units: false
is: HMDB00089
name: Cytidine
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17562

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM man6p c
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
name: D-Mannose 6-phosphate
is: CHEBI:17369
is: HMDB01078

metaM creat e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:16919
name: creatine
constant: false

metaR HOCTDACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR HSAT1ly
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110051#
fast: false
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110051#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_72c85915_33da_4d0c_a1f5_670b4b6f8178
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5406
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: PNLIP
is: P16233
initial amount: NaN

metaR PROD2m
reversible: false
fast: false
kinetic law: MODEL1310110051#
type: Reaction
name: Proline dehydrogenase (m)
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000254
is: SBO:0000176

metaM omhpal c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: w-hydroxypalmiticacid
notes: FORMULA: C16H30O3 CHARGE: -1
type: Species
boundary condition: false
is: HMDB06294

http://identifiers.org/biomodels.db/MODEL1310110051#_542582b4_5f69_4296_b711_61a79463c051
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:386757
constant: false
name: SLC6A10P
initial concentration: NaN

metaM HC01405 m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: (S)-Hydroxyoctanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
type: Species
is: CHEBI:28632

http://identifiers.org/biomodels.db/MODEL1310110051#_29131fbe_b018_42ff_baf1_1b024e55fb5b
type: Species
is encoded by: hsa:6576
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: D9HTE9
is: SBO:0000252
name: SLC25A1
has only substance units: false

metaM subeac c
has only substance units: false
is: HMDB00893
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C8H12O4 CHARGE: -2
is: SBO:0000247
initial amount: NaN
type: Species
name: suberic acid

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_fac54027_6f9f_49e8_8c5d_7cd5b787aa51
is encoded by: hsa:1339
type: Species
constant: false
is: Q02221
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: COX6A2

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM bilglcur e
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57767
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaM 3hpp m
type: Species
is: SBO:0000247
initial amount: NaN
name: 3-hydroxypropionate
is: HMDB00700
is: CHEBI:16510
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false

metaR PRASCS
product: MODEL1310110051#
is described by: ECO:0000269
kinetic law: MODEL1310110051#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.3.2.6
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110051#

metaR r0644
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110051#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

metaM hpdcacoa c
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: heptadecanoyl coa
initial concentration: 1.0
is: HMDB06497
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110051#_eb509a08_6eaf_47a9_9760_21bb2a65ae26
is: Q8TE04
constant: false
is encoded by: hsa:53354
initial concentration: NaN
name: PANK1
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaM 4abut c
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628
is: HMDB00112
initial amount: NaN
boundary condition: false
name: 4-Aminobutanoate
has only substance units: false

metaM 5mthf c
is: C00440
has only substance units: false
is: HMDB01396
name: 5-Methyltetrahydrofolate
is: SBO:0000247
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: CHEBI:3729
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_174712de_75fb_46b3_9b40_e1deb4763d5f
constant: false
type: Species
is encoded by: hsa:5279
name: PIGC
is: Q92535
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR FOLt2le
reactant: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000134
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: folate transport via anion exchange
product: MODEL1310110051#

metaM acmana c
has only substance units: false
boundary condition: false
name: N-acetyl-D-mannosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
initial concentration: 1.0
is: SBO:0000247
is: HMDB01129
type: Species
constant: false
initial amount: NaN
is: CHEBI:17122

http://identifiers.org/biomodels.db/MODEL1310110051#_816ed316_cd58_4de7_82f9_22d26bed940c
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:7296
is: SBO:0000252
name: TXNRD1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_cfb3f660_cfca_426c_b38c_5ae0a20a1b4d
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC43A2
has only substance units: false
constant: false
is encoded by: hsa:124935
is: Q8N370
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_6f77b889_3260_41d4_9e11_e50440a1d77e
is encoded by: hsa:2639
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: GCDH
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f72e4b9c_dbc7_43fc_9531_0230707e4fd3
is encoded by: hsa:8140
constant: false
initial concentration: NaN
has part: Q8IV97
name: SLC3A2:SLC7A5
type: Species
has only substance units: false
is: SBO:0000297
boundary condition: true
initial amount: NaN

metaM ksi deg26 l
name: keratan sulfate I, degradation product 26
is: CHEBI:58343
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00061
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
boundary condition: false
constant: false

metaR P5CR
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reversible: false
fast: false
name: pyrroline-5-carboxylate reductase
reactant: MODEL1310110051#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134

metaM creat c
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
name: creatine
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00064
initial concentration: 1.0
has only substance units: false
is: CHEBI:16919

http://identifiers.org/biomodels.db/MODEL1310110051#_6f56d561_46f8_424a_915d_0259fa7c233c
has only substance units: false
initial amount: NaN
is: Q8WUX1
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:92745
name: SLC38A5
boundary condition: true

metaR r2526
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR KSIt
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: false
is: SBO:0000185
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: keratan sulfate I transport, golgi to extracellular
fast: false

metaR ALCD21 L
type: Reaction
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110051#
name: alcohol dehydrogenase (L-1,2-propanediol)
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD

metaM 4abut e
is: C00334
is: HMDB00112
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: 4-Aminobutanoate
is: SBO:0000247
has only substance units: false
is: CHEBI:3628
notes: FORMULA: C4H9NO2 CHARGE: 0

metaR r2525
reactant: MODEL1310110051#
fast: false
type: Reaction
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

http://identifiers.org/biomodels.db/MODEL1310110051#_b7874238_eb5f_4e18_af41_663a044c5ec4
constant: false
initial concentration: NaN
name: GALNT4
initial amount: NaN
type: Species
is encoded by: hsa:8693
has only substance units: false
is: SBO:0000252
is: Q8N4A0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_035b6746_5760_4c43_95f1_0c95d2cb87c3
is encoded by: hsa:AI373818
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: _AI373818_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_55141f05_a6fe_415a_bff0_b95a93590d89
is: SBO:0000252
has only substance units: false
is: O75038
is encoded by: hsa:9651
boundary condition: true
initial amount: NaN
type: Species
name: PLCH2
initial concentration: NaN
constant: false

metaR B MANNASEly
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110051#
name: beta-mannosidase, lysosomal
kinetic law: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction

metaM ksii core2 deg1 l
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 1
is: CHEBI:57737
is: HMDB00868
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_d039d67f_27c7_4f32_a0ea_4049b20ad9a2
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: _LOC647190_1_c
has only substance units: false
is encoded by: hsa:LOC647190

http://identifiers.org/biomodels.db/MODEL1310110051#_9535ce98_1530_41e6_b3b3_221fb7d1ddbe
initial concentration: NaN
is: B3KVI7
has only substance units: false
is encoded by: hsa:3712
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: IVD
is: SBO:0000252

metaM n2m2nmn l
has only substance units: false
is: CHEBI:17588
type: Species
notes: FORMULA: C50H84N4O36 CHARGE: 0
initial amount: NaN
boundary condition: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
constant: false
is: HMDB00742
initial concentration: 1.0
is: SBO:0000247

metaM 5mthf e
has only substance units: false
is: SBO:0000247
name: 5-Methyltetrahydrofolate
is: CHEBI:3729
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01396
is: C00440

metaR AKGMALtm
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
kinetic law: MODEL1310110051#
fast: false
name: alpha-ketoglutarate/malate transporter
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110051#

metaR ANTHte
reversible: true
name: Transport of anthranilate
is described by: ECO:0000134
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110051#

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaR NACHEX14ly
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
type: Reaction

metaR r1751
name: Y+LAT2 Utilized transport
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
reversible: false
product: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110051#

metaR URAt
kinetic law: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reversible: true
fast: false
is: SBO:0000185
name: uracil transport via facilated diffusion
reactant: MODEL1310110051#

metaM fn2m2masn g
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:32984
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
is: SBO:0000247
constant: false

metaM ei11ecoa x
constant: false
is: http://identifiers.org/pubchem.compound/24892790
name: 11-eicosenoylcoa
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false

metaR ICDHyrm
is: SBO:0000176
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reversible: true
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
name: Isocitrate dehydrogenase (NADP+)
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
is described by: ECO:0000269
modifier: MODEL1310110051#

metaM ctp n
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: CTP(4-)
has only substance units: false
is: HMDB00082
boundary condition: false
constant: false
type: Species
is: CHEBI:37563

metaM retfa c
initial amount: NaN
name: fatty acid retinol
is: HMDB00305
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
is: CHEBI:50211
is: SBO:0000247

metaR GBAl
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.45
name: Glucosylceramidase

metaM ura e
name: uracil
is: CHEBI:17568
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00300
has only substance units: false
initial concentration: 1.0

metaR GGH 7DHFe
kinetic law: MODEL1310110051#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7DHF), extracellular

http://identifiers.org/biomodels.db/MODEL1310110051#_18396849_fa15_4582_b068_b88f594f1f11
is: SBO:0000252
type: Species
name: NDUFS1
boundary condition: true
has only substance units: false
is: P28331
constant: false
initial concentration: NaN
is encoded by: hsa:4719
initial amount: NaN

metaM cs e deg6 l
is: CHEBI:57455
type: Species
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
boundary condition: false
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
initial amount: NaN
is: HMDB01354
initial concentration: 1.0
is: SBO:0000247

metaM xoldiolone r
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
type: Species
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB02197
is: CHEBI:28477

metaR GCC2cm
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
product: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110051#
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true

metaR r1752
type: Reaction
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110051#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110051#

metaR S2L2N2M2MASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110051#
reversible: false
type: Reaction
name: s2l2n2m2masn transport, extracellular to lysosome
is: SBO:0000185
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000

metaM HC02213 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:28031
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR MM8Cg
reversible: false
kinetic law: MODEL1310110051#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.113
is: SBO:0000176
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reactant: MODEL1310110051#
fast: false
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000000

metaM dnad c
name: Deamino-NAD+
is: C00857
is: HMDB01179
is: CHEBI:18304
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR ALADGLNexR
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000304
reversible: true
is: SBO:0000185
product: MODEL1310110051#
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_c4d7c3dd_5a65_4858_8e2a_67b9f5551a22
is: Q86SK9
constant: false
has only substance units: false
is encoded by: hsa:79966
initial amount: NaN
type: Species
boundary condition: true
name: SCD5
is: SBO:0000252
initial concentration: NaN

metaR r0650
modifier: MODEL1310110051#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36

metaM hpdcacoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
type: Species
is: HMDB06497
is: SBO:0000247
boundary condition: false
constant: false
name: heptadecanoyl coa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f213a3d6_08e6_4a15_b770_517648839f25
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: E9PAX2
name: G6PC2
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:57818

http://identifiers.org/biomodels.db/MODEL1310110051#_10c9d0d2_27fe_4132_a651_33e8cbf92649
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: IDH2
is: P48735
is: SBO:0000252
is encoded by: hsa:3418
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_26c28229_3135_41f6_b07d_a57ebf6ee5d8
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AI972237
is: SBO:0000252
name: _AI972237_1_c
initial amount: NaN
has only substance units: false

metaM ach e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
is: HMDB00895
boundary condition: false
is: CHEBI:15355
type: Species
name: acetylcholine
initial amount: NaN
has only substance units: false

metaM acetol c
name: hydroxyacetone
has only substance units: false
is: CHEBI:27957
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: HMDB06961
initial concentration: 1.0

metaM pep c
is: CHEBI:18021
is: HMDB00263
is: C00074
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: Phosphoenolpyruvate
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM dcsptn1crn c
is: HMDB06321
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaM CE5236 n
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28002
has only substance units: false
constant: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952

http://identifiers.org/biomodels.db/MODEL1310110051#_39db0509_3370_43de_a424_91ea18fe701d
name: SLC1A4
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:6509
type: Species
is: P43007

metaR r0651
reactant: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110051#
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
kinetic law: MODEL1310110051#

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_4e3d8bc0_bf68_45c0_afad_ab5c228b6939
initial amount: NaN
is: O43772
name: SLC25A20
initial concentration: NaN
is encoded by: hsa:788
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaM etha c
initial concentration: 1.0
type: Species
name: etha[c]
is: CHEBI:57603
has only substance units: false
boundary condition: false
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
initial amount: NaN
is: SBO:0000247
is: HMDB00149
constant: false

metaR SCP22x
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
fast: false
is described by: ECO:0000000
name: Sterol carrier protein 2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true
is: SBO:0000185

metaR DNDPt24m
type: Reaction
fast: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
product: MODEL1310110051#
name: dTDP transport via dADP antiport
kinetic law: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000185

metaR LALDO2x
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
is described by: ECO:0000269
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaM ctp c
is: CHEBI:37563
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: CTP
is: HMDB00082
constant: false
is: C00063
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaM thf m
is: HMDB01846
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
constant: false

metaR r0954
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
reversible: true
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000
name: MCT 1 Transport reaction
type: Reaction
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_63902dca_55ef_49d8_9418_020c6fc03bfe
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54995
is: Q9NWU1
type: Species
name: OXSM
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_3445e9cc_d697_4b00_8820_320a8880c290
is encoded by: hsa:8813
has part: O60762
is encoded by: hsa:54344
name: DPM3:DPM1:DPM2
has part: Q86TM7
is: SBO:0000297
constant: false
has part: O94777
is encoded by: hsa:8818
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaR FAOXC204C205x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR DNDPt13m
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110051#
is: SBO:0000185
modifier: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
name: dADP transport via ATP antiport
is described by: ECO:0000269
product: MODEL1310110051#

metaR OCD11CRNCACT
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR P45027A11m
fast: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110051#
reversible: false

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_dcbf69c3_1a16_4633_9d6f_a56d4129111e
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: P49327
initial amount: NaN
boundary condition: true
name: FASN
initial concentration: NaN
is encoded by: hsa:2194

metaM thf l
has only substance units: false
type: Species
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: CHEBI:57453
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaR S6T10g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
type: Reaction
fast: false
product: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaM ksi pre16 g
initial amount: NaN
has only substance units: false
is: C00130
boundary condition: false
type: Species
constant: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
initial concentration: 1.0
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 16
is: SBO:0000247
is: CHEBI:58053

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is: P21399
name: ACO1
initial concentration: NaN
is encoded by: hsa:48
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false

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initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: SLC7A8
is: Q86U05
type: Species
is encoded by: hsa:23428
boundary condition: true
has only substance units: false

metaR HDCEAtr
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110051#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110051#_2e98e9b2_7b05_4784_a5f3_579944204196
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: TXNRD3
type: Species
is: Q86VQ6
initial concentration: NaN
is encoded by: hsa:114112
initial amount: NaN

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has only substance units: false
boundary condition: true
is encoded by: hsa:112724
initial amount: NaN
is: SBO:0000252
name: RDH13
type: Species
constant: false
initial concentration: NaN
is: B3KVA3

http://identifiers.org/biomodels.db/MODEL1310110051#_c8cb03bd_9834_4827_8ca0_da2ba95a0f0e
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: PDE9A
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
constant: false

metaM c101coa c
is: HMDB00651
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
name: decenoylcoa
initial amount: NaN
boundary condition: false

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type: Species
name: _AA177072_1_c
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA177072
boundary condition: true
is: SBO:0000252

metaM 4abut m
is: CHEBI:16865
type: Species
initial amount: NaN
constant: false
name: 4-Aminobutanoate
is: C00334
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: SBO:0000247
boundary condition: false
is: HMDB00112
initial concentration: 1.0

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initial concentration: NaN
type: Species
name: PLCB1
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: Q9NQ66
is encoded by: hsa:23236
is: SBO:0000252

metaM lnlnca e
name: alpha-linolenate
is: CHEBI:32387
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
boundary condition: false

metaR FAOXC200180x
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
name: Beta oxidation of long chain fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000

metaM lnlncgcoa m
name: gamma-linolenoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
has only substance units: false
is: CHEBI:57363
type: Species
constant: false

metaR C80CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_6601d785_01fe_4691_bab8_5759c94d37d0
type: Species
is encoded by: hsa:113
boundary condition: true
initial amount: NaN
name: ADCY7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: P51828

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_a659979c_cc82_4c12_8470_b42344d4ac58
boundary condition: true
constant: false
is: P55084
is encoded by: hsa:3032
name: HADHB
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR r0655
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is: SBO:0000176
reactant: MODEL1310110051#
reversible: true
type: Reaction
product: MODEL1310110051#
modifier: MODEL1310110051#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110051#

metaM HC02205 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
type: Species
is: CHEBI:28099
name: prostaglandin-b2
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

metaM 4abut n
boundary condition: false
is: HMDB00112
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate
is: C00334
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_4a85f936_7ab5_48eb_acaf_92956f5047e0
constant: false
is encoded by: hsa:2509
name: _2509_1_e
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_3536069b_828e_4118_9400_f94081191380
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8525
initial concentration: NaN
name: DGKZ
is: SBO:0000252
type: Species
is: G3V0F6

metaR CYSTSERex
reversible: false
modifier: MODEL1310110051#
is described by: ECO:0000269
name: L-cystine/glycine exchanger (cystine in)
fast: false
is: SBO:0000185
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110051#
type: Reaction

metaM g6p r
name: D-Glucose 6-phosphate
boundary condition: false
is: C00092
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:61548
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_8ffc5bef_19b4_4dc9_9a5b_85e338c6d590
name: DGKB
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9Y6T7
is: SBO:0000252
constant: false
is encoded by: hsa:1607
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_e5226c6b_1316_4453_a0a0_40046276e694
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8818
is: SBO:0000297
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species
boundary condition: true
has part: P37287
initial amount: NaN
is encoded by: hsa:5277

http://identifiers.org/biomodels.db/MODEL1310110051#_abf19e0b_f7f3_4747_befe_b945acb579f9
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P33121
initial amount: NaN
name: ACSL1
constant: false
has only substance units: false
is encoded by: hsa:2180

http://identifiers.org/biomodels.db/MODEL1310110051#_635590f9_63a3_4891_ae2a_2ab0dd05cafe
is encoded by: hsa:80201
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: B3KT70
is: SBO:0000252
initial amount: NaN
name: HKDC1

metaM 4mzym int2 r
constant: false
boundary condition: false
type: Species
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: HMDB06838
name: 4-Methylzymosterol intermediate 2
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR FORtr
fast: false
is: SBO:0000185
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
reversible: true
type: Reaction
name: FOR transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110051#

metaM ach c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
boundary condition: false
constant: false
is: HMDB00895
has only substance units: false
is: CHEBI:15355
name: acetylcholine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_0cfc22a8_6085_46cd_a061_d8043720986b
boundary condition: true
type: Species
is encoded by: hsa:10449
has only substance units: false
constant: false
initial concentration: NaN
is: P42765
name: ACAA2
is: SBO:0000252
initial amount: NaN

metaR r0652
kinetic law: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR r2519
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
name: Utilized transport
reversible: true
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_8afb05eb_5589_4992_ac32_4de365cc7c0c
type: Species
is: P00325
name: ADH1B
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:125
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_af20db78_b5df_4497_b15b_fd32de89c67c
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: P11310
name: ACADM
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:34

metaR ACt2m
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110051#
type: Reaction
fast: false
product: MODEL1310110051#
name: acetate mitochondrial transport via proton symport
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_35bb6115_9251_4b8a_b4ec_db40622f94f0
constant: false
is encoded by: hsa:2592
name: GALT
initial amount: NaN
has only substance units: false
is: B2RAT6
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaM subeac x
initial concentration: 1.0
constant: false
boundary condition: false
name: suberic acid
is: HMDB00893
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C8H12O4 CHARGE: -2
is: SBO:0000247

metaM ksii core2 pre2 g
name: keratan sulfate II biosynthesis, precursor 2
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: HMDB00175
is: CHEBI:58053
is: SBO:0000247
constant: false
initial amount: NaN
is: C00130

metaM sucsal m
initial concentration: 1.0
initial amount: NaN
name: Succinic semialdehyde
has only substance units: false
constant: false
is: CHEBI:57706
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: SBO:0000247
is: HMDB01259
boundary condition: false
type: Species

metaM lnlnca c
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
constant: false
name: alpha-linolenate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:32387

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR FAOXC14C12x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR DTTPtn
name: dTTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110051#
reversible: true

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110051#
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
name: H2O transport, lysosomal
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM amp m
boundary condition: false
is: CHEBI:456215
is: HMDB00045
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
name: AMP(2-)
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_5e61d17e_98ff_4da3_9f40_9c761c19c69b
is: Q96M32
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:122481
has only substance units: false
initial amount: NaN
name: AK7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_a0aabb3f_4dc7_40ed_a5ca_fc6416729671
type: Species
boundary condition: true
initial amount: NaN
name: MAN1A1
constant: false
is: P33908
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4121
has only substance units: false

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial amount: NaN
is: SBO:0000247
name: prostaglandin-b2
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28099
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_939d1939_a0f8_4099_94bc_3c72c17f69b8
is: SBO:0000252
name: ALAS2
is: Q5JZF5
boundary condition: true
is encoded by: hsa:212
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaM adn m
name: adenosine
has only substance units: false
is: CHEBI:16335
is: HMDB00050
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
constant: false
type: Species

metaM hs deg5 l
has only substance units: false
is: HMDB00158
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 5
constant: false
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: CHEBI:17895

metaR TSTSTERONESULT
modifier: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
reversible: false
is: SBO:0000176
name: testosterone sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.14
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110051#_74bd90fb_df87_40d5_9136_27d900703ba8
name: ACAA1
has only substance units: false
is encoded by: hsa:30
is: Q96CA6
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM ctp e
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
name: CTP(4-)
is: HMDB00082
is: CHEBI:37563

http://identifiers.org/biomodels.db/MODEL1310110051#_a54d252d_a316_404f_81b9_970a1c0d4479
boundary condition: true
is encoded by: hsa:5298
is: SBO:0000252
constant: false
is: Q9UBF8
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: PI4KB

metaM amp r
name: AMP
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
is: C00020
has only substance units: false
constant: false
is: HMDB00045
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_e9acfc75_9ad8_4db0_84b7_a2fade2a8cdf
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4731
constant: false
is: SBO:0000252
boundary condition: true
name: NDUFV3
has only substance units: false
type: Species
is: P56181

metaM ser L e
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
boundary condition: false
name: L-serine
is: HMDB00187
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:17115

http://identifiers.org/biomodels.db/MODEL1310110051#_a2000f09_6b43_4243_b713_403eb9603e71
is: P49902
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: NT5C2
is encoded by: hsa:22978
constant: false

metaM ksi deg29 l
is: HMDB00143
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
name: keratan sulfate I, degradation product 29
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:12936

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_aef3b744_fff2_4eff_8ff5_253d3dc7eb4a
boundary condition: true
is: Q9BY32
has only substance units: false
type: Species
name: ITPA
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3704
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_d0318d7c_5ec2_4e02_9ab6_8b110cf00731
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4695
name: NDUFA2
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: O43678

metaR CERT1gt
reactant: MODEL1310110051#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
reversible: true
product: MODEL1310110051#
name: ceramide transport protein
is described by: ECO:0000304
kinetic law: MODEL1310110051#

metaM nrvnc c
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB02368
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:32392
name: nervonate

metaM thf e
initial amount: NaN
constant: false
is: CHEBI:57453
is: SBO:0000247
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
boundary condition: false
is: HMDB01846
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
initial concentration: 1.0

metaM pep m
is: HMDB00263
is: SBO:0000247
initial concentration: 1.0
name: Phosphoenolpyruvate
initial amount: NaN
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
constant: false
is: C00074
boundary condition: false
has only substance units: false
is: CHEBI:18021

http://identifiers.org/biomodels.db/MODEL1310110051#_fb8f6238_2b39_45c7_97e7_f0b789fc5a5f
has only substance units: false
constant: false
type: Species
name: _AI769281_1_e
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI769281
boundary condition: true

metaM hs deg9 l
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17115
type: Species
has only substance units: false
is: HMDB00187
name: heparan sulfate, degradation product 9
constant: false
boundary condition: false
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_0dfb043a_9744_4d27_8d98_610518807f37
initial concentration: NaN
has part: Q02153
is encoded by: hsa:2977
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2983
is: SBO:0000297
has only substance units: false
type: Species
has part: P33402
name: GUCY1A2:GUCY1B3

metaM dgsn c
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species
constant: false
is: HMDB00085
name: Deoxyguanosine
initial amount: NaN
boundary condition: false
is: C00330
is: SBO:0000247
is: CHEBI:17172
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_54537bfe_26c4_47c5_b5a6_57f41ad6f491
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q96PD7
constant: false
name: DGAT2
initial amount: NaN
has only substance units: false
is encoded by: hsa:84649

metaR PRISTtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000185
reversible: true
name: prist peroxisomal transport
is described by: ECO:0000000
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_61c1aa16_ea86_40df_80c1_48687a251ecd
is encoded by: hsa:6821
is: SBO:0000252
constant: false
has only substance units: false
is: P51687
name: SUOX
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaM tymsf e
is: SBO:0000247
boundary condition: false
is: HMDB06409
initial amount: NaN
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial concentration: 1.0
has only substance units: false
constant: false
name: Tyramine O-sulfate
type: Species

metaM ser L c
has only substance units: false
constant: false
name: L-serine
is: SBO:0000247
is: CHEBI:17115
is: HMDB00187
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

metaR IDPtn
product: MODEL1310110051#
is: SBO:0000185
reversible: true
name: IDP nuclear transport
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reactant: MODEL1310110051#

metaR FAOXC184m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR C8CRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_0aad6e77_573a_433e_8d98_d07a04f2d6f8
is: P07451
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CA3
is encoded by: hsa:761
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaR GARFT
type: Reaction
kinetic law: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.1.2.2
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
name: phosphoribosylglycinamide formyltransferase
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110051#

metaM strdnccrn c
name: stearidonyl carnitine
is: HMDB06463
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-

metaR r0377
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
modifier: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110051#
reversible: false

metaM lnlncgcoa c
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368

http://identifiers.org/biomodels.db/MODEL1310110051#_e0dd29c4_b07c_4c33_a0cf_b7b32020af0a
is encoded by: hsa:55753
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9ULD0
name: OGDHL
constant: false

metaM thf c
initial amount: NaN
is: CHEBI:57453
boundary condition: false
constant: false
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247
has only substance units: false
type: Species
is: C00101
is: HMDB01846
initial concentration: 1.0
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaM nrvnc e
is: SBO:0000247
constant: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
boundary condition: false
is: HMDB02368
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:32392
has only substance units: false
name: nervonate

metaM T antigen g
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:22783
has only substance units: false
boundary condition: false
notes: FORMULA: C14H24NO10X CHARGE: 0
name: T antigen (core 1)
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_04a6e8fc_4c0f_4ec8_9e70_123c83ecaa1c
type: Species
is: SBO:0000252
is encoded by: hsa:AI620219
boundary condition: true
constant: false
name: _AI620219_1_c
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_900db17a_3f69_40f5_a75b_a3ba8788d199
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR ACt2r
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
fast: false
name: acetate reversible transport via proton symport
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_195a0f07_8fde_4814_a408_1f4f06963757
type: Species
constant: false
boundary condition: true
name: SLC7A6
initial concentration: NaN
is encoded by: hsa:9057
is: SBO:0000252
has only substance units: false
is: Q92536
initial amount: NaN

metaM no c
is: C00533
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
initial amount: NaN
initial concentration: 1.0
name: Nitric oxide
is: CHEBI:16480
constant: false

metaR FAOXC18480m
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110051#
name: Beta oxidation of fatty acid
reversible: false
fast: false
is described by: ECO:0000000

metaR G14T11g
is: SBO:0000176
reactant: MODEL1310110051#
reversible: false
product: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR CITt4 2
reversible: true
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
name: citrate transport via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is: SBO:0000185

metaR CYTK9n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dCTP),nuclear
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_2b2cf2a4_611f_4ca8_b864_f90803446213
name: HK1
is: P78542
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3098
is: SBO:0000252
constant: false

metaR UDPACGALtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reactant: MODEL1310110051#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: udpacgal intracellular transport
reversible: true

metaR DHORTS
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.2
fast: false
is: SBO:0000176
name: dihydroorotase
is described by: ECO:0000269
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#

metaR DESAT22 2p
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_18e1abfd_b138_412d_87fa_715b47e889e7
initial amount: NaN
has only substance units: false
is encoded by: hsa:218
initial concentration: NaN
is: P30838
constant: false
is: SBO:0000252
boundary condition: true
name: ALDH3A1
type: Species

metaM retinal r
initial amount: NaN
is: CHEBI:15035
has only substance units: false
boundary condition: false
is: HMDB01358
type: Species
initial concentration: 1.0
constant: false
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: SBO:0000247

metaM betald m
constant: false
is: HMDB01252
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
boundary condition: false
type: Species
initial amount: NaN
name: betaine aldehyde

metaM gt3 hs g
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:28424
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
initial concentration: 1.0
boundary condition: false
name: GT3
is: SBO:0000247

metaR UGLCNACtg
fast: false
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
name: UDP-GlcNAc Golgi transport via CMP antiport
is described by: ECO:0000269

metaR S4TASE4ly
is described by: ECO:0000000
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
reactant: MODEL1310110051#

metaR FACOAL161
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110051#
is described by: ECO:0000000
name: fatty-acid--CoA ligase (hexadecenoate)
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR 2AMADPTm
fast: false
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
modifier: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110051#_5b87515f_6b95_4f12_8cdb_91f9f58b97fb
boundary condition: true
initial concentration: NaN
type: Species
name: ALDH3A2
has only substance units: false
initial amount: NaN
is encoded by: hsa:224
is: P51648
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_6d68bcd0_ab21_4eaf_948a_f26e997240bb
has only substance units: false
is encoded by: hsa:6578
type: Species
is: SBO:0000252
is: Q92959
initial concentration: NaN
boundary condition: true
name: SLCO2A1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_6c59b825_e506_4da9_9df5_54dbd6ff299a
name: ITPKB
initial concentration: NaN
boundary condition: true
is: P27987
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:3707
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b3d2fc5b_004d_43e9_96b0_c2d6b9ee07ec
is: SBO:0000252
is encoded by: hsa:51809
name: GALNT7
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is: Q86SF2
initial concentration: NaN

metaR G14T5g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110051#
reactant: MODEL1310110051#

metaM no e
type: Species
initial concentration: 1.0
is: C00533
is: HMDB03378
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
constant: false
name: Nitric oxide
is: CHEBI:16480

http://identifiers.org/biomodels.db/MODEL1310110051#_a88016cd_2f1c_4a74_997a_d49fd69869fc
name: NME1:NME2
is: SBO:0000297
type: Species
constant: false
initial concentration: NaN
has part: P22392
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4831
is encoded by: hsa:4830
has part: P15531

metaM pro D e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
name: D-proline
has only substance units: false
is: CHEBI:16313
is: HMDB03411
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

metaR AG13T18g
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

metaR HESTRATRIOLtr
type: Reaction
is described by: ECO:0000000
name: hydroxylated estrogen derivative transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
fast: false
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_410a1e4a_a96e_4e20_b3cb_53d9b353af7a
constant: false
initial amount: NaN
type: Species
is: Q6FG42
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: NDUFA7
is encoded by: hsa:4701
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2a838d5e_3e0a_41db_90c5_bfc321a1785c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:84105
boundary condition: true
constant: false
is: Q9H0N5
type: Species
name: PCBD2
has only substance units: false

metaM ksi pre19 g
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 19
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
constant: false
is: SBO:0000247
is: C00130
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_cfbca4d5_02a7_4c74_bc22_fcc8505cb0e0
has only substance units: false
constant: false
name: LHPP
is: Q9H008
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:64077

http://identifiers.org/biomodels.db/MODEL1310110051#_2451c38d_1de5_4d87_aa5e_6d355b8ca2f1
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: _R06874_1_r
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:R06874

metaR KAS8
modifier: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
name: b-ketoacyl synthetase (palmitate, n-C16:0)
kinetic law: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#

metaR S6TASE16ly
type: Reaction
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
fast: false

metaR RE1898C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
name: RE1898
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_c8decab6_4728_4772_aa30_eef2af695245
name: TKTL1
is encoded by: hsa:8277
is: SBO:0000252
is: B7Z7I0
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaM 10fthf7glu e
has only substance units: false
boundary condition: false
is: CHEBI:16236
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: HMDB00108
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](7)
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaR FATP9t
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
name: fatty acid electroneutral transport
product: MODEL1310110051#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110051#

metaM decdicoa c
type: Species
has only substance units: false
initial amount: NaN
name: decadienoylcoa
is: SBO:0000247
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_fec3cb7e_f09a_4bf5_a4e6_fc3887a1580a
initial amount: NaN
boundary condition: true
name: PIK3CA:PIK3R1
has only substance units: false
is encoded by: hsa:5295
initial concentration: NaN
is: SBO:0000297
constant: false
type: Species
has part: P27986

metaR ABUTD
product: MODEL1310110051#
name: Aminobutyraldehyde dehydrogenase
type: Reaction
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reactant: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a3123a53_346c_4d6c_a3fa_0fc45a737238
initial amount: NaN
is encoded by: hsa:204
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: AK2

http://identifiers.org/biomodels.db/MODEL1310110051#_c960c0e0_4d74_48ca_8f88_b5cc22b084c4
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:4830
type: Species
boundary condition: true
name: NME1:NME2

metaM hdd2coa x
is: HMDB03945
boundary condition: false
has only substance units: false
is: CHEBI:61526
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
initial amount: NaN
name: (E)-hexadec-2-enoyl-CoA(4-)
constant: false
is: SBO:0000247

metaR ODECOAtx
name: fatty acid intracellular transport
is described by: ECO:0000000
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR FAOXC226C227m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR CHAT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
name: Choline O-acetyltransferase
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_f55a0109_651d_4927_a45b_1f1f10b0abb2
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR RTOTALFATPc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaM acmana r
has only substance units: false
initial concentration: 1.0
is: CHEBI:17122
name: N-acetyl-D-mannosamine
boundary condition: false
is: HMDB01129
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c042b9d4_b92f_4d5f_b6ef_312fa046d7a1
boundary condition: true
is encoded by: hsa:26227
is: O43175
initial concentration: NaN
type: Species
name: PHGDH
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaM pro D c
name: D-proline
has only substance units: false
constant: false
is: CHEBI:16313
initial concentration: 1.0
is: HMDB03411
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

metaM ksi deg20 l
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
boundary condition: false
has only substance units: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 20

metaR r2532
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
product: MODEL1310110051#

metaR r0504
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
reversible: true
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
fast: false
modifier: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
kinetic law: MODEL1310110051#

metaM g6p c
name: D-Glucose 6-phosphate
is: SBO:0000247
is: C00092
boundary condition: false
initial concentration: 1.0
is: HMDB01401
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: CHEBI:61548

http://identifiers.org/biomodels.db/MODEL1310110051#_ac12d269_a944_4db4_a977_b96e77e2a87a
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: COX7A2
type: Species
is encoded by: hsa:1347
is: H0UI06
has only substance units: false
boundary condition: true
constant: false

metaM ump n
is: HMDB00288
is: SBO:0000247
is: CHEBI:57865
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
constant: false
name: UMP(2-)
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR 34DHXMANDACOX NADP
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_774d3219_0436_444d_bdd2_7f4cc84b1ba5
is: Q96N66
name: MBOAT7
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:79143
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_16690d2f_7eb1_41f2_b122_92a212a45a6b
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2530
initial concentration: NaN
initial amount: NaN
is: A8K8P8
is: SBO:0000252
name: FUT8

http://identifiers.org/biomodels.db/MODEL1310110051#_db61d9fc_9b21_49c9_916c_09280c1ed48c
type: Species
is: Q92820
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8836
name: GGH
constant: false
boundary condition: true

metaR SUCRe
name: sucrose hydrolyzing enxyme, extracellular
reactant: MODEL1310110051#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.10
is version of: http://identifiers.org/ec-code/3.2.1.20
product: MODEL1310110051#
is described by: ECO:0000269
kinetic law: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f0f5d400_709b_4acc_89f8_9111af911c9e
has only substance units: false
initial amount: NaN
type: Species
is: B4DGD7
boundary condition: true
name: IDS
is encoded by: hsa:3423
is: SBO:0000252
initial concentration: NaN
constant: false

metaM o2 r
initial amount: NaN
has only substance units: false
is: C00007
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: O2
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110051#_02078715_0e49_4635_b489_ec126bc2b9f4
initial amount: NaN
boundary condition: true
is: P26439
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3284
name: HSD3B2
constant: false
type: Species
is: SBO:0000252

metaR GCCcm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
kinetic law: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110051#_7cf60ad3_0476_48d4_acb2_2ea38138a1aa
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:80308
name: FLAD1
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_5f14d0e7_46fb_43e5_bf62_865f0da72058
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI971036_1_m
initial concentration: NaN
is encoded by: hsa:AI971036
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_7b01cc2c_9d9a_42f2_9b47_210f71de311e
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55163
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: PNPO
is: Q9NVS9

http://identifiers.org/biomodels.db/MODEL1310110051#_41cd7e63_905d_4b64_91cf_a57f5b35cf79
initial concentration: NaN
initial amount: NaN
name: ACOX1
constant: false
is: B4DK61
is encoded by: hsa:51
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR BILIRED
is: SBO:0000176
type: Reaction
reversible: false
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
name: Nad(p)h biliverdin reductase
is version of: http://identifiers.org/ec-code/1.3.1.24
kinetic law: MODEL1310110051#

metaM CE5586 c
boundary condition: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
initial amount: NaN
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:58732
initial concentration: 1.0
constant: false

metaM CE5125 x
is: CHEBI:12947
initial amount: NaN
boundary condition: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: (2S)-pristanoyl-CoA

metaR FACOAL170
reversible: true
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
product: MODEL1310110051#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110051#_c82f3476_8c6c_4eac_a26b_8e25441c3035
is: SBO:0000252
initial amount: NaN
is: O95168
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: NDUFB4
is encoded by: hsa:4710
type: Species

metaR r2534
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110051#

metaR AG13T16g
modifier: MODEL1310110051#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction

metaR PHETHPTOX2
is: SBO:0000176
kinetic law: MODEL1310110051#
is described by: ECO:0000269
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
reactant: MODEL1310110051#
fast: false
reversible: false
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.14.16.1
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
product: MODEL1310110051#
type: Reaction

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_9b18b418_59be_4341_9c15_04a3322ba5aa
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9BTY2
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:2519
name: FUCA2

metaR HDECEACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_8608e040_1ced_4069_b7e1_88d6f4b3febf
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:686
name: BTD
is: SBO:0000252
initial concentration: NaN
type: Species
is: P43251

metaR r0360
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110051#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
reversible: false
product: MODEL1310110051#

metaM pi m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:43474
is: C00009
name: hydrogenphosphate
boundary condition: false
is: HMDB00973
type: Species
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110051#_1b4363ea_40e4_4506_a303_1dd98d6ac10d
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR CRNrtx
product: MODEL1310110051#
name: reversible transport of L-Carnitine in peroxisome
type: Reaction
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000185
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110051#_738457d9_c894_41cb_bf43_63180b72057b
is encoded by: hsa:760
name: CA2
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: P00918
has only substance units: false

metaR G6PDH2c
kinetic law: MODEL1310110051#
is: SBO:0000176
type: Reaction
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000134
reversible: false
name: glucose 6-phosphate dehydrogenase
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.49
fast: false
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:found in rats. HMP shunt reactions are cytosolic. Irreversible reaction, coefficient changed to 3

metaR SQLEr
is version of: http://identifiers.org/ec-code/1.14.13.132
fast: false
is described by: ECO:0000134
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
modifier: MODEL1310110051#
name: Squalene epoxidase, endoplasmic reticular (NADP)
is: SBO:0000176

metaR ARACHt
kinetic law: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
name: fatty acid transport via diffusion
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction

metaM ser L m
constant: false
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
boundary condition: false
has only substance units: false
initial amount: NaN
name: L-serine
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_5127c53c_dc27_4bd6_9ba2_09f1a2b3e419
is: O75874
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3417
name: IDH1
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true

metaR 4NPHSULT
is: SBO:0000176
reversible: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.8.2.1
modifier: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is described by: ECO:0000269
name: 4-Nitrophenol Sulfotransferase

metaM dopasf e
has only substance units: false
name: dopamine 3-O-sulfate
is: HMDB06275
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:37946
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
boundary condition: false

metaM pi l
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:43474
name: hydrogenphosphate
boundary condition: false
is: HMDB00973
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110051#_bf67c98f_9013_41bb_b8f0_bdc2f013512e
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: Q9Y2P5
name: SLC27A5
is encoded by: hsa:10998
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_2667c00e_5781_444f_9e45_b9539b70b936
is encoded by: hsa:2629
name: GBA
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_5d3bffa5_b57d_459a_86ba_90546740e5e5
initial amount: NaN
constant: false
name: PIGC
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5279
is: SBO:0000252
type: Species

metaM ump r
is: HMDB00288
initial concentration: 1.0
boundary condition: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: UMP

metaM fmn c
is: C00061
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: HMDB01520
initial amount: NaN
name: FMN
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58210
has only substance units: false
boundary condition: false

metaM hdcea c
is: HMDB03229
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
constant: false
is: CHEBI:32372
initial amount: NaN
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
initial concentration: 1.0
boundary condition: false

metaM 5tedtricoa m
type: Species
initial concentration: 1.0
name: 5,8,11-tetradecatrienoylcoa
boundary condition: false
has only substance units: false
is: HMDB02288
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4

metaM c12dc x
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H34NO6 CHARGE: -1
name: dodecanedioyl carnitine
is: HMDB11123
constant: false
boundary condition: false
is: C05279

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM 6dhf e
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB06563

metaR r1010
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Postulated transport reaction
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110051#

metaM vacc e
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
name: trans-vaccenate
is: CHEBI:30828
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+

http://identifiers.org/biomodels.db/MODEL1310110051#_e00f83b7_18e8_41d5_9c55_58bbe3a5cbdd
name: ATG9B
is: Q674R7
boundary condition: true
type: Species
is encoded by: hsa:285973
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR AACOAT
product: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
type: Reaction
is described by: ECO:0000269
name: Acetoacetyl-CoA:acetate CoA-transferase
is version of: http://identifiers.org/ec-code/6.2.1.16

http://identifiers.org/biomodels.db/MODEL1310110051#_c7a29501_b555_4eef_b175_b6cf3c956af3
is encoded by: hsa:23563
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: CHST5
initial concentration: NaN

metaM CE1617 r
is: SBO:0000247
is: HMDB01358
has only substance units: false
constant: false
name: 9-cis-retinoate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
type: Species
is: CHEBI:17898
boundary condition: false

metaR EX 3ivcrn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaM hs deg16 l
is: SBO:0000247
has only substance units: false
is: CHEBI:21338
boundary condition: false
constant: false
is: HMDB02704
name: heparan sulfate, degradation product 16
initial concentration: 1.0
type: Species
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
initial amount: NaN

metaR r1011
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
fast: false
name: Transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:

metaR RE3005M
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110051#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3005
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_796fae30_32af_4936_aa2e_1e6709b88a89
name: CTPS2
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q9NRF8
initial amount: NaN
is encoded by: hsa:56474

metaM pi n
is: HMDB00973
constant: false
is: CHEBI:43474
type: Species
has only substance units: false
name: hydrogenphosphate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110051#_82354126_149c_44f2_a8a0_47f0ef5a1c2e
name: ND3
boundary condition: true
type: Species
is encoded by: hsa:4537
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P03897

metaR KYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.64
name: L-Kynurenine:2-oxoglutarate aminotransferase
modifier: MODEL1310110051#
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_4cb7f37e_3319_4fa2_afd9_8d8924bb9516
has only substance units: false
is encoded by: hsa:55907
is: Q8NFW8
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: CMAS
initial amount: NaN

metaM CE5236 c
has only substance units: false
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
is: HMDB03952
is: CHEBI:28002
constant: false
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
initial concentration: 1.0
initial amount: NaN

metaR CYSGLUexR
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110051#
fast: false
name: L-cysteine/L-glutamine reversible exchanger
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaR C142CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR r0502
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is: SBO:0000176
reversible: true
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.113
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#

metaR r1012
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: Postulated transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:

metaM ksi pre35 g
boundary condition: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 35
is: SBO:0000247
type: Species
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110051#_d7bd9a4e_3fa2_4aa9_a98b_8b37d6d52f2b
is: SBO:0000252
is encoded by: hsa:5295
name: PIK3R1
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: E7EX19
boundary condition: true

metaM hdd2coa c
is: CHEBI:61526
boundary condition: false
is: HMDB03945
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
name: trans-Hexadec-2-enoyl-CoA
initial concentration: 1.0
constant: false
has only substance units: false
is: C05272
type: Species
initial amount: NaN

metaR SPMTDe
fast: false
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: SPMTDe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185

metaR DHCHOLESTANATEtm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: lipid, flip-flop intracellular transport
fast: false
reactant: MODEL1310110051#
is: SBO:0000185

metaR C4DCCACT
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaM dlnlcgcoa c
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:27979
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
initial concentration: 1.0
constant: false

metaM o2 x
has only substance units: false
is: HMDB01377
is: SBO:0000247
is: C00007
constant: false
initial concentration: 1.0
name: O2
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

http://identifiers.org/biomodels.db/MODEL1310110051#_67327d75_d06c_4c26_b258_6b0d6c01a827
initial concentration: NaN
is encoded by: hsa:38
name: ACAT1
type: Species
constant: false
is: P24752
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r1013
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000
reversible: false
name: Transport reaction
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_7a4c5cbd_af9b_41cb_a02e_0a1079e33cfc
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P30613
name: PKLR
has only substance units: false
is encoded by: hsa:5313
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_704719a7_5b66_44d4_bd15_18ad4f1e08d3
boundary condition: true
constant: false
name: _AI435857_1_x
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:AI435857

metaR PNTOte
reactant: MODEL1310110051#
type: Reaction
fast: false
reversible: true
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of (R)-Pantothenate
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110051#

metaR RE1526M
is described by: ECO:0000000
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is: SBO:0000176
type: Reaction
name: RE1526
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR AMETtd
is: SBO:0000185
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000134
reversible: true
type: Reaction
name: diffusion of S-Adenosyl-L-methionine

metaR ARACHDt2
reactant: MODEL1310110051#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110051#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110051#

metaM pi c
is: C00009
type: Species
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
has only substance units: false
initial concentration: 1.0
is: HMDB00973
is: SBO:0000247
constant: false
name: hydrogenphosphate
is: CHEBI:43474
initial amount: NaN

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_56453482_8dc3_4d78_ab89_316e4377324a
initial amount: NaN
boundary condition: true
is encoded by: hsa:23563
name: CHST5
is: Q9GZS9
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaR FACOAL2251
fast: false
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
name: fatty-acid--CoA ligase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true

metaM hexc c
initial concentration: 1.0
is: CHEBI:31013
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB02356
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
boundary condition: false
name: cerotate
type: Species
constant: false

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR SUCCACT
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR FRUt4
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: D-fructose transport via sodium cotransport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110051#

metaR DDECCRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_c1eb3232_a97d_4de4_9de3_e7dbf22f6ac0
initial concentration: NaN
is encoded by: hsa:54407
is: SBO:0000252
has only substance units: false
constant: false
is: Q96QD8
initial amount: NaN
name: SLC38A2
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_9dda7d60_6eaf_4f08_a4e2_1d6010605957
initial amount: NaN
constant: false
name: HADHA
initial concentration: NaN
type: Species
is encoded by: hsa:3030
has only substance units: false
boundary condition: true
is: SBO:0000252
is: E9KL44

metaM hdd2coa m
constant: false
type: Species
is: C05272
boundary condition: false
has only substance units: false
initial amount: NaN
name: trans-Hexadec-2-enoyl-CoA
is: SBO:0000247
is: HMDB03945
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
initial concentration: 1.0

metaM 6thf e
boundary condition: false
is: http://identifiers.org/pubchem.compound/169691
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
name: hexaglutamyl folate (THF)

metaR EX 3ddcrn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR FACOAL2252
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
name: fatty-acid--CoA ligase
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176

metaR ACALDtm
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
name: acetaldehyde mitochondrial diffusion
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
reversible: true
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_27cd6d7e_b42b_4f39_b8f0_fe3dbeee0e10
name: NOS1
is: B4DG68
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:4842
boundary condition: true
initial amount: NaN

metaM dcsptn1crn m
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB06321
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c55a4c38_abd3_4b11_a739_bed6d7a69cbc
name: FDPS
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P14324
boundary condition: true
type: Species
is encoded by: hsa:2224
constant: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM tststerones c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB02833
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
name: testosterone sulfate

metaR r2539
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185
reversible: true
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Postulated transport reaction

metaM 34dhphe e
type: Species
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
constant: false
is: HMDB00181
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: L-dopa
boundary condition: false
is: CHEBI:15765

metaM pi e
is: C00009
type: Species
boundary condition: false
is: HMDB00973
has only substance units: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:43474
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110051#_4a897773_3058_4c09_af23_303334a6a270
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6675
is: Q16222
is: SBO:0000252
name: UAP1

metaM adrncrn m
boundary condition: false
is: C00318
is: SBO:0000247
is: CHEBI:16347
is: HMDB00062
name: Adrenyl carnitine
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C29H49NO4 CHARGE: 0
constant: false
has only substance units: false

metaR LNSTLSr
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
reactant: MODEL1310110051#
name: lanosterol synthase
reversible: false
fast: false
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110051#
is described by: ECO:0000134
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.4.99.7

metaM ump g
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00288
name: UMP(2-)
is: SBO:0000247
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
constant: false

metaM estrone r
name: estrone
is: HMDB00145
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17263
type: Species
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
initial amount: NaN
initial concentration: 1.0

metaR ACNACNGALGBSIDEtg
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
name: acnacngalgbside hs intracellular transport
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185

metaR C3DCe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaM 4mop e
boundary condition: false
name: 4-methyl-2-oxopentanoate
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
is: HMDB00695
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17865

metaR RE3346C
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
reversible: true
name: RE3346
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#

metaM xol7ah2 m
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:28047
is: HMDB06893

http://identifiers.org/biomodels.db/MODEL1310110051#_783d5caa_1137_4b22_bce4_ac79c4411b28
has only substance units: false
name: ALDH1A3
initial amount: NaN
constant: false
is encoded by: hsa:220
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P47895

http://identifiers.org/biomodels.db/MODEL1310110051#_cef6b0b9_78b5_4f50_83e1_4a498c0c5886
is encoded by: hsa:4709
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q6IB80
constant: false
name: NDUFB3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_effa3062_08c2_43a0_b68a_78e30b2118fd
is: Q9P019
is encoded by: hsa:29085
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: PHPT1
boundary condition: true

metaM amp c
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2
type: Species
is: CHEBI:3322
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00045
name: AMP

metaR RE1903R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
reactant: MODEL1310110051#
reversible: true
is: SBO:0000176
name: RE1903
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
type: Reaction

metaM mgacpail hs r
type: Species
has only substance units: false
is: HMDB00220
is: C00249
is: SBO:0000247
initial amount: NaN
is: CHEBI:7896
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false
initial concentration: 1.0
constant: false

metaM fpram c
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: CHEBI:58478
initial concentration: 1.0
has only substance units: false
is: C04640
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB06211
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640

http://identifiers.org/biomodels.db/MODEL1310110051#_c69e3879_7e94_4c41_bfa0_120cc80140b6
is: SBO:0000252
is encoded by: hsa:AA419122
name: _AA419122_1_c
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaR GTHRDt
reversible: true
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
type: Reaction
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR MECOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110051#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#

metaM ksi pre24 g
initial concentration: 1.0
is: C00130
constant: false
boundary condition: false
is: HMDB00175
initial amount: NaN
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 24
is: CHEBI:58053
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f674a31e_4398_4f40_bce6_c8f83ffc8ad1
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:1376
name: CPT2
is: P23786
is: SBO:0000252
has only substance units: false

metaR FAOXC14C12m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR NAt3 1
type: Reaction
name: sodium proton antiporter (H:NA is 1:1)
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110051#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false

metaM 34dhphe c
boundary condition: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: SBO:0000247
name: L-dopa
is: HMDB00181
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15765
has only substance units: false

metaR NACHEX21ly
modifier: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110051#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
kinetic law: MODEL1310110051#

metaR PROSTGH2t
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110051#
reversible: true
fast: false
name: Prostaglandin H2 transport
is described by: ECO:0000269

metaR BILDGLCURt
reversible: true
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110051#
type: Reaction
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
kinetic law: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
fast: false
is: SBO:0000185
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_5be298c5_1dbd_4eae_8d64_8c327fef9db4
is: O14556
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: GAPDHS
is: SBO:0000252
is encoded by: hsa:26330
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_281231d4_07ba_4356_af3c_c80721f4a99c
type: Species
is encoded by: hsa:2629
has only substance units: false
is: B7Z5G2
name: GBA
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_3d717afa_445f_4ea1_8d42_3951c78192d7
initial concentration: NaN
has only substance units: false
name: GCNT3
is: O95395
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:9245

metaR RE2973C
type: Reaction
is: SBO:0000176
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#

metaR ACNACNGALGBSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: acnacngalgbside hs transport
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
type: Reaction
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_a42c0560_72ea_4e63_9cea_3d966c0f7140
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: GPX7
is encoded by: hsa:2882
is: Q96SL4

http://identifiers.org/biomodels.db/MODEL1310110051#_848b37da_72d2_47b7_a54b_b12c2077a504
name: ADCY4
is: Q8NFM4
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:196883
boundary condition: true
type: Species

metaM gln L m
is: CHEBI:18050
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00641
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
has only substance units: false
name: L-glutamine

metaM pi g
is: HMDB00973
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:43474
initial amount: NaN
name: hydrogenphosphate
constant: false
initial concentration: 1.0

metaM xylu L c
is: SBO:0000247
is: CHEBI:17399
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial amount: NaN
is: HMDB00751
initial concentration: 1.0
name: L-xylulose
constant: false

metaR GLCAASE9ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_0d3598cd_38b5_45bc_a6c4_2c703bb7f168
name: ATIC
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:471
constant: false
boundary condition: true
is: P31939
type: Species
initial concentration: NaN

metaM ksii core2 deg7 l
is: HMDB01354
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 7
is: CHEBI:57455
initial concentration: 1.0
type: Species
notes: FORMULA: C44H73N4O30X CHARGE: 0
constant: false

metaM amp e
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
is: HMDB00045
has only substance units: false
is: CHEBI:456215
type: Species
name: AMP
initial amount: NaN
constant: false
boundary condition: false
is: C00020
initial concentration: 1.0

metaR RE1534M
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
name: RE1534
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176

metaM 4mop c
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
boundary condition: false
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
is: CHEBI:17865
is: HMDB00695
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_6b953ccd_ee69_411a_a4a1_b3dbaff90743
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: _BE042354_1_m
is encoded by: hsa:BE042354
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR SERDGLYexR
type: Reaction
fast: false
name: D-Serine/Glycine reversible exchange
reversible: true
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110051#

metaM dlnlcgcoa m
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:27979
type: Species
initial concentration: 1.0
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM lnlncgcoa x
has only substance units: false
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57363

http://identifiers.org/biomodels.db/MODEL1310110051#_4bc2c0fc_f6ad_4616_bb79_1feb1e68149c
is: SBO:0000252
type: Species
initial amount: NaN
name: ACOT2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10965
constant: false
is: P49753
boundary condition: true

metaR NACHEX1ly
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176

metaR UAG2EMAi
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.1.3.14
reversible: false
is: SBO:0000176
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_0965a435_dc6a_4f40_acbc_a186bf8a05e5
type: Species
boundary condition: true
initial concentration: NaN
name: XDH
is encoded by: hsa:7498
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P47989

metaR r2535
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
type: Reaction
reversible: true

metaM retinal 11 cis c
type: Species
initial concentration: 1.0
is: HMDB02152
is: CHEBI:16066
has only substance units: false
initial amount: NaN
name: 11-cis-retinal
boundary condition: false
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247

metaM 2octdectecoa x
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: 2,6,9,12-octadecatetraenoylcoa
type: Species
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN

metaM retinal c
is: CHEBI:15035
boundary condition: false
name: retinal
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01358
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
constant: false
type: Species

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
constant: false
has only substance units: false
is: CHEBI:57449
is: SBO:0000247
boundary condition: false
name: trans-3-decenoyl-CoA
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_120b98da_f0ed_4ef4_9fd0_6acf4ce308f7
is: O95167
initial concentration: NaN
constant: false
name: NDUFA3
is encoded by: hsa:4696
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaR LINKDEG1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
name: degradation of proteoglycan linkage region, lysosomal

metaR LEUTA
name: leucine transaminase
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR 2MB2COAc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_7361032b_c1fb_434e_b06e_e0d5e274c0d8
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: ATP2B4
is encoded by: hsa:493
is: P23634
boundary condition: true
initial concentration: NaN

metaR ACGAMK
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.59
reversible: false
product: MODEL1310110051#
name: N-acetylglucosamine kinase
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110051#
is: SBO:0000176

metaR NAIt
is: SBO:0000185
kinetic law: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
fast: false
name: Na+ / iodide cotransport
reversible: true
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD

metaM hexc e
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB02356
initial concentration: 1.0
type: Species
is: CHEBI:31013
constant: false
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
boundary condition: false
name: cerotate

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_9a02b2df_a9d0_47ba_aacf_426abaf3710e
has only substance units: false
type: Species
initial concentration: NaN
name: ACAD9
constant: false
is: SBO:0000252
is: Q9H845
boundary condition: true
is encoded by: hsa:28976
initial amount: NaN

metaM tststerones e
type: Species
name: testosterone sulfate
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
initial amount: NaN
is: HMDB02833
initial concentration: 1.0
constant: false

metaR SUBERCACT
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_441aa66d_408d_49ea_a7c4_b5709c6c6f3e
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:771
boundary condition: true
is: O43570
name: CA12

http://identifiers.org/biomodels.db/MODEL1310110051#_fb0c0600_de8d_4e7a_9065_7edd1e6aabaf
initial concentration: NaN
is encoded by: hsa:2184
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: P16930
boundary condition: true
name: FAH
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_eab8fab3_63d0_4f2a_89c3_b0374aa58f20
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: Q92185
is: SBO:0000252
constant: false
is encoded by: hsa:6489
name: ST8SIA1
boundary condition: true

metaR GLCNACPT L
product: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.15
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_6e6311b0_2962_4e0f_9ad8_96f3663c93a0
type: Species
initial concentration: NaN
name: PSPH
has only substance units: false
constant: false
initial amount: NaN
is: P78330
is encoded by: hsa:5723
boundary condition: true
is: SBO:0000252

metaR r0210
reactant: MODEL1310110051#
is described by: ECO:0000000
name: L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
product: MODEL1310110051#
reversible: false
is: SBO:0000176
type: Reaction
fast: false

metaR PYNP2r
type: Reaction
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
fast: false
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#

metaR MM5ag
is described by: ECO:0000000
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113

http://identifiers.org/biomodels.db/MODEL1310110051#_69db5740_2a7d_4eae_8cf2_7e3ae38981ec
is: SBO:0000252
is: O76083
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5152
name: PDE9A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_5401a41f_17f7_4ca9_b498_860943130ab5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84693
type: Species
initial concentration: NaN
initial amount: NaN
name: MCEE
boundary condition: true
constant: false
is: Q96PE7

metaR DMHPTCRNCPT2
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is: SBO:0000176
name: 2,6 dimethylheptanoly CoA carnitine transferase
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
reversible: true

metaR r0660
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
product: MODEL1310110051#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
is: SBO:0000176
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR S6TASE26ly
kinetic law: MODEL1310110051#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110051#
reversible: true
fast: false
type: Reaction

metaR GLNtm
name: L-glutamine transport via electroneutral transporter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110051#

metaR FAOXC3DC
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaR r0963
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000185
name: Facilitated diffusion

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM glyald m
is: SBO:0000247
type: Species
is: HMDB01051
name: D-glyceraldehyde
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
initial concentration: 1.0
boundary condition: false

metaM udpgal c
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
is: CHEBI:58439
initial amount: NaN
is: HMDB00302
name: UDP-D-galactose(2-)
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR METtec
reversible: true
reactant: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110051#
type: Reaction
name: L-methionine transport via diffusion (extracellular to cytosol)
product: MODEL1310110051#
fast: false
is described by: ECO:0000269
is: SBO:0000185

metaM sphings l
boundary condition: false
is: HMDB00252
is: CHEBI:57756
name: sphingosine(1+)
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaR r0661
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
is: SBO:0000176
reversible: false

metaR VALt5m
type: Reaction
name: Valine reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
is: SBO:0000185

metaR G14T21g
modifier: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110051#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_864e904c_16d2_4ee1_9522_4fa238b010f0
initial concentration: NaN
type: Species
is encoded by: hsa:9791
initial amount: NaN
is: SBO:0000252
name: PTDSS1
constant: false
is: P48651
boundary condition: true
has only substance units: false

metaM 34dhoxmand m
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
name: 3,4-Dihydroxymandelate
is: HMDB01866
is: CHEBI:27637
initial amount: NaN
has only substance units: false

metaR KSII CORE2tly
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
name: keratan sulfate II (core 2) transport, extracellular to lysosome
kinetic law: MODEL1310110051#
fast: false

metaR D3AIBTm
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
product: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_a1ce35c1_d3b4_43ff_890c_8eae5199a83c
is: SBO:0000252
is: B2RAT6
is encoded by: hsa:2592
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: GALT
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0f65ee74_6621_4f6f_8d2f_2477c7d5f80f
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:30833
is: Q8TCD5
name: NT5C

metaM o2 c
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: O2
is: CHEBI:15379
is: HMDB01377
has only substance units: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007

metaR FAOXC183C163m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_4e9c55d6_20ca_4a18_bd52_025b5c92fe5d
initial concentration: NaN
has only substance units: false
constant: false
is: P21953
is encoded by: hsa:594
initial amount: NaN
name: BCKDHB
type: Species
boundary condition: true
is: SBO:0000252

metaM 2dr5p c
is: SBO:0000247
name: 2-deoxy-D-ribose 5-phosphate(2-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57651
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
boundary condition: false
type: Species
is: HMDB01031
constant: false
has only substance units: false

metaM ura c
initial amount: NaN
is: CHEBI:17568
name: Uracil
is: HMDB00300
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00106
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
constant: false
boundary condition: false
has only substance units: false

metaM CE1926 e
is: CHEBI:15748
is: HMDB00127
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
name: gama-carboxyethyl-hydroxychroman
constant: false

metaM C02470 c
is: http://identifiers.org/pubchem.compound/5485
is: HMDB00881
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
boundary condition: false
is: C02470
initial amount: NaN
has only substance units: false
name: Xanthurenic acid

http://identifiers.org/biomodels.db/MODEL1310110051#_67186998_d547_480b_93b1_16026151d4ce
name: NDUFB5
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:4711
is: SBO:0000252
initial amount: NaN
is: O43674

metaR Htg
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
name: proton diffusion (Golgi)
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#

metaM 5tedtricoa x
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
initial amount: NaN
name: 5,8,11-tetradecatrienoylcoa
type: Species
boundary condition: false
is: HMDB02288
is: SBO:0000247
has only substance units: false

metaR S6T11g
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
type: Reaction
product: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110051#

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR C181CRNt
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
fast: false
is: SBO:0000185
name: C181 transport into the mitochondria
reversible: false
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_7740ad95_e12e_4597_af43_c123cda31d6c
is encoded by: hsa:AV717590
name: _AV717590_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaM 4mop m
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial amount: NaN
boundary condition: false
name: 4-methyl-2-oxopentanoate
constant: false
is: SBO:0000247
is: CHEBI:17865
is: HMDB00695

http://identifiers.org/biomodels.db/MODEL1310110051#_cef0c962_1c83_4fbc_b5a5_a12feb01c384
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:10861
initial amount: NaN
is: Q9H2B4
name: SLC26A1
constant: false
boundary condition: true
initial concentration: NaN

metaR NH4tn
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: ammonia nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false

metaM 3docopencoa x
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
type: Species
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN
constant: false

metaR FAOXC2051843m
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110051#
name: Beta oxidation of fatty acid
fast: false
is: SBO:0000176
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_eb036861_c4f3_4fdb_96c9_f2e0e6fb46c9
has part: O15269
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: SPTLC1:SPTLC2
has part: O15270
is encoded by: hsa:10558
has only substance units: false
is encoded by: hsa:9517
is: SBO:0000297
constant: false

metaM c6crn c
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false
is: HMDB00705
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: hexanoyl carnitine

metaM o2 e
is: SBO:0000247
boundary condition: false
is: C00007
name: O2
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
initial amount: NaN

metaR CTPtn
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#
name: CTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110051#
reactant: MODEL1310110051#

metaR FATP4t
reactant: MODEL1310110051#
is described by: ECO:0000269
kinetic law: MODEL1310110051#
fast: false
type: Reaction
name: fatty acid electroneutral transport
reversible: true
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
modifier: MODEL1310110051#

metaM adrncrn c
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C29H49NO4 CHARGE: 0
is: C00318
is: CHEBI:16347
is: HMDB00062
name: Adrenyl carnitine
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR PRODt2r
product: MODEL1310110051#
name: D-proline reversible transport via proton symport
reactant: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
type: Reaction
kinetic law: MODEL1310110051#
reversible: true
is described by: ECO:0000304
is: SBO:0000185

metaM g1m8masn r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C76H127N2O60X CHARGE: 0
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: C05875
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_266e15e1_fae3_4a81_a61a_481b31497c3d
is encoded by: hsa:9388
name: LIPG
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9Y5X9
has only substance units: false

metaM CE4795 x
is: SBO:0000247
is: CHEBI:57923
initial amount: NaN
constant: false
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795

metaR NCKt
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-K+ exchange
reversible: true
modifier: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
fast: false

metaM but c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17968
constant: false
name: butyrate
is: HMDB00039
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

metaM udpgal g
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
is: CHEBI:58439
is: HMDB00302
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0c4f3a45_b3ac_4ec1_8ae2_91a6ca5f3f5f
is: P19367
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: HK1
boundary condition: true
type: Species
is encoded by: hsa:3098
has only substance units: false

metaM 1pipdn2c x
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: HMDB01084
name: 1-piperideine-2-carboxylate
type: Species
is: CHEBI:16187
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

metaR NH4tp
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: true
name: ammonia peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110051#_4786fb96_2bb4_4a45_9be1_abdc46d22ff0
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:NM 001929
has only substance units: false
is: SBO:0000252
type: Species
name: _NM_001929_1_c

metaR r0960
reversible: true
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reactant: MODEL1310110051#
type: Reaction
is: SBO:0000185

metaR CHATn
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.6
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
fast: false

metaM gln L e
has only substance units: false
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: L-glutamine
type: Species
constant: false
is: HMDB00641
initial amount: NaN

metaR IDOURte
reactant: MODEL1310110051#
name: L-iduronate transport, extracellular
kinetic law: MODEL1310110051#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110051#

metaR ARAB Lt
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
kinetic law: MODEL1310110051#
is: SBO:0000185
name: L-arabinoase extracellular transport

http://identifiers.org/biomodels.db/MODEL1310110051#_40b90382_6372_4e86_9686_94f4336648d7
is encoded by: hsa:1109
initial concentration: NaN
name: AKR1C4
has only substance units: false
type: Species
is: P17516
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaM xol7ah2 c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB06893
is: SBO:0000247
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
boundary condition: false
constant: false

metaR ADK3
is: SBO:0000176
product: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
fast: false
is described by: ECO:0000269
name: adentylate kinase (GTP)
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_2690a492_68f9_48bd_954c_cfd75e6e958a
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: O00483
is encoded by: hsa:4697
name: NDUFA4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0e1bd68b_f95c_4ae9_992b_1d87479e2617
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PDE9A
constant: false
is encoded by: hsa:5152
type: Species

metaM c6crn e
name: hexanoyl carnitine
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00705
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C13H25NO4 CHARGE: 0

metaM cs b deg3 l
is: CHEBI:21338
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB02704
is: SBO:0000247
type: Species
notes: FORMULA: C37H55NO38S2 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110051#_3e4e695a_380a_4afc_a8aa_4eb60c2b8f94
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: RPN2
is: P04844
is encoded by: hsa:6185
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR EX tetdece1crn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaR URCN
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.49
name: URCN
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176

metaR FAS160COA
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110051#
product: MODEL1310110051#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110051#
reversible: false
is described by: ECO:0000269

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR r0666
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1

metaM but e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
is: SBO:0000247
name: butyrate
has only substance units: false
is: HMDB00039
type: Species
boundary condition: false

metaR PSERT
kinetic law: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.52
name: phosphoserine transaminase
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110051#

metaR PSYGCHe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM 7thf e
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
initial concentration: 1.0
boundary condition: false
is: HMDB06559
initial amount: NaN
has only substance units: false
name: heptaglutamyl folate (THF)

metaR LYStip
is described by: ECO:0000000
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
fast: false
reactant: MODEL1310110051#
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110051#
name: L-lysine transport, peroxisomal (irreversible)

http://identifiers.org/biomodels.db/MODEL1310110051#_3396b9b5_61be_4d29_a99d_c564fe6a4448
initial concentration: NaN
type: Species
has only substance units: false
name: ZADH2
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:284273
is: Q4G1C4

metaR FAOXC16C14m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaR RE0583C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000176
name: RE0583

metaM udpgal e
has only substance units: false
boundary condition: false
is: CHEBI:58439
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
is: HMDB00302
is: SBO:0000247
type: Species
name: UDP-D-galactose(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_df8be16a_f89a_44d3_b12b_228a23a33ae5
initial amount: NaN
is encoded by: hsa:AA629629
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: _AA629629_1_m
initial concentration: NaN

metaR SGPL12r
modifier: MODEL1310110051#
is: SBO:0000176
name: Sphingosine-1-phosphate lyase
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
type: Reaction
product: MODEL1310110051#
fast: false

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR r0962
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
name: Facilitated diffusion
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaR GBA
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.2.1.45
modifier: MODEL1310110051#
fast: false
name: Glucosylceramidase
type: Reaction
reversible: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176

metaM gln L c
initial amount: NaN
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
name: L-glutamine
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: HMDB00641

http://identifiers.org/biomodels.db/MODEL1310110051#_bf7b25a8_1634_483a_a4aa_82b3ea13f224
boundary condition: true
is: Q15849
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8170
name: SLC14A2

metaR DNDPt8m
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
name: dADP transport via dUDP antiport
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_2c4e54e3_abf5_42a8_9835_8584ff538dfc
name: AOC2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:314
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_4837907f_79a8_435f_96e3_343e9d436e8e
is: E7EPT3
is encoded by: hsa:501
constant: false
name: ALDH7A1
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_68f34856_dcda_4e2d_ae4e_b0b3531eabfb
boundary condition: true
type: Species
is: P36269
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2687
name: GGT5
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_4c96eda1_34d9_4df4_9a1a_9e8de27ff6df
is: SBO:0000252
is: P12074
has only substance units: false
is encoded by: hsa:1337
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: COX6A1

metaR SEBACIDTD
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM pi r
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
name: hydrogenphosphate
is: C00009
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00973
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_7d879e24_2bd4_4581_b78c_09188ea8f05b
boundary condition: true
initial amount: NaN
is encoded by: hsa:83530
initial concentration: NaN
name: _83530_1_c
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaR r0365
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000176
reversible: false
modifier: MODEL1310110051#

metaR r0208
reversible: true
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.4.1.1
fast: false
type: Reaction
reactant: MODEL1310110051#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#

metaR FAOXC2051843x
name: Beta oxidation of long chain fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000176

metaR LYSOXp
fast: false
name: L-lysine oxidase, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
type: Reaction
product: MODEL1310110051#

metaR SPHS1Ptr
is: SBO:0000185
reactant: MODEL1310110051#
name: sphingosine-1-phosphate transport
fast: false
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ

metaR S3TASE1ly
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110051#
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false

metaM sphings c
initial amount: NaN
name: sphingosine(1+)
is: SBO:0000247
has only substance units: false
is: HMDB00252
is: CHEBI:57756
type: Species
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial concentration: 1.0
constant: false

metaR Htr
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reversible: true
name: H transporter, endoplasmic reticulum
reactant: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#

metaM kynate c
initial concentration: 1.0
is: CHEBI:58454
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00715
is: SBO:0000247
has only substance units: false
name: kynurenate
type: Species
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717

metaR PROt2r
modifier: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
type: Reaction
kinetic law: MODEL1310110051#
name: L-proline reversible transport via proton symport
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_3399f095_6e2c_402a_9d45_293a3a72087f
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:728226
name: _728226_1_e
type: Species

metaR r1014
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
is described by: ECO:0000000
product: MODEL1310110051#
name: Postulated transport reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR GLCtly
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: glucose efflux from lysosome
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ed57df72_60da_4575_aaef_679909b84bc0
is: P55084
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3032
name: HADHB

http://identifiers.org/biomodels.db/MODEL1310110051#_ce2e4e7e_8a71_460c_8d77_1f7f3ff1c7a9
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: SDHA
type: Species
is encoded by: hsa:6389
is: P31040
boundary condition: true

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR RE3301C
modifier: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000176
name: RE3301
is version of: http://identifiers.org/ec-code/3.1.4.4

http://identifiers.org/biomodels.db/MODEL1310110051#_cafa6592_0270_4e75_b621_349df73f06c2
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11000
is: Q5K4L6
name: SLC27A3
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_4a647037_ce51_42c5_80de_0c0d7723581e
boundary condition: true
has only substance units: false
name: COX6B2
initial amount: NaN
is: SBO:0000252
type: Species
is: Q6YFQ2
initial concentration: NaN
is encoded by: hsa:125965
constant: false

metaM 2octdectecoa m
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: 2,6,9,12-octadecatetraenoylcoa
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110051#_2dfbe2ec_e904_459d_b236_965917df66ca
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9060
type: Species
initial amount: NaN
name: PAPSS2
is: SBO:0000252
constant: false
is: O95340

metaM orot5p c
initial concentration: 1.0
name: Orotidine 5'-phosphate
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57538
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: HMDB00218
has only substance units: false
is: C01103
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2f051249_ff99_46da_af7d_60d145108109
initial amount: NaN
name: SUCLG2
type: Species
constant: false
boundary condition: true
is: Q96I99
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8801
has only substance units: false

metaM HC02204 e
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
type: Species
is: CHEBI:27624
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: prostaglandin-b1

metaR ADK1
name: adenylate kinase
reversible: true
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
is described by: ECO:0000269
is: SBO:0000176

metaM vacc c
is: SBO:0000247
is: C08367
initial amount: NaN
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
has only substance units: false
constant: false
initial concentration: 1.0
name: trans-vaccenate
boundary condition: false
is: CHEBI:30828

metaR VACCt
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000185

metaM hdcea e
is: CHEBI:32372
initial concentration: 1.0
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
is: HMDB03229
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaM 34dhoxmand c
is: HMDB01866
is: CHEBI:27637
has only substance units: false
boundary condition: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: 3,4-Dihydroxymandelate

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM 3mb2coa m
name: 3-methylbut-2-enoyl-CoA(4-)
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB01493
is: CHEBI:57344
initial amount: NaN

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_bc1e2ec7_6bb6_4231_a164_2fa58c568583
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:51181
is: Q7Z4W1
has only substance units: false
name: DCXR
boundary condition: true
initial amount: NaN

metaR GGH 10FTHF6GLUe
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
modifier: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_10483914_7bc3_4ffb_a033_dc4da15f3430
is: F6KD01
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: PTEN
is encoded by: hsa:5728

http://identifiers.org/biomodels.db/MODEL1310110051#_89619c50_7e59_4fc2_beab_dd97e4733f38
is: A0PJJ9
is encoded by: hsa:2686
name: GGT7
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_bc419fd5_3c5e_492d_a276_abfc245554ce
constant: false
is encoded by: hsa:51477
name: ISYNA1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: B3KRT1

metaR PHYHx
is version of: http://identifiers.org/ec-code/1.14.11.18
is described by: ECO:0000269
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
reversible: false
is: SBO:0000176
name: Phytanoyl-CoA dioxygenase, peroxisomal

metaR MM6bg
is: SBO:0000176
reversible: false
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000

metaM docosahexcoa m
is: SBO:0000247
name: 3,7,10,13,16,19-docosahexenoylcoa
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN

metaR MI1345PP
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110051#
is: SBO:0000176
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
modifier: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110051#
fast: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR FAOXC16C14x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)x
type: Reaction

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reactant: MODEL1310110051#
reversible: false
product: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM o2 m
type: Species
boundary condition: false
is: CHEBI:15379
is: C00007
is: SBO:0000247
initial concentration: 1.0
is: HMDB01377
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
has only substance units: false
constant: false

metaM dopasf c
initial amount: NaN
initial concentration: 1.0
name: dopamine 3-O-sulfate
has only substance units: false
is: HMDB06275
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:37946
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690

http://identifiers.org/biomodels.db/MODEL1310110051#_acc7aaa9_92ba_4ee2_893d_b73efcce3b58
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8876
name: VNN1
has only substance units: false
initial concentration: NaN
type: Species
is: O95497

metaM c8dc x
boundary condition: false
is: SBO:0000247
name: suberyl carnitine
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C15H26NO6 CHARGE: -1
is: HMDB00893
initial amount: NaN

metaR r1019
product: MODEL1310110051#
name: Postulated transport reaction
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000185

metaR GALASE9ly
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110051#
name: beta-galactosidase, lysosomal
reactant: MODEL1310110051#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_98af46a7_dd45_49f7_af18_22a45c8a6dcf
is encoded by: hsa:6549
is: Q9UBY0
constant: false
initial amount: NaN
name: SLC9A2
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM HC02204 c
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:27624
name: prostaglandin-b1
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959

http://identifiers.org/biomodels.db/MODEL1310110051#_c123e365_fae2_4fc7_9e0b_641259e56efb
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is: B7Z723
name: LIPF
is encoded by: hsa:8513
initial amount: NaN

metaR G14T6g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110051#
modifier: MODEL1310110051#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176

metaR EX 35cgmp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3',5'-Cyclic GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_69a24d15_07b8_4127_ad8e_54881bf51674
type: Species
initial amount: NaN
is encoded by: hsa:2629
is: SBO:0000252
is: B7Z6S1
name: GBA
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR GLYCLTtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
kinetic law: MODEL1310110051#
name: glycolate transport into peroxisome
type: Reaction
product: MODEL1310110051#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185

metaR 4NPHte
type: Reaction
reactant: MODEL1310110051#
name: xenobiotic transport
kinetic law: MODEL1310110051#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110051#
fast: false

metaM HC01407 m
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:28276
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
name: (S)-Hydroxyhexanoyl-CoA
is: SBO:0000247
initial amount: NaN

metaR r0968
fast: false
reversible: false
kinetic law: MODEL1310110051#
type: Reaction
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaM hs l
type: Species
is: CHEBI:28815
name: heparan sulfate, free chain
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c990c4fe_3c35_4cb8_a872_cd1e7e8b5c3c
initial amount: NaN
type: Species
is encoded by: hsa:211
has only substance units: false
name: ALAS1
is: Q5JAM2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_3e233b1e_994c_40ec_88f4_4b40539eda96
name: EGFL8
is: Q99944
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:80864
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r1018
reactant: MODEL1310110051#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#

metaM 10fthf6glu e
has only substance units: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
type: Species
is: CHEBI:16236
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00108
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false

metaR MTHFDm
kinetic law: MODEL1310110051#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
fast: false

metaM tddedi2coa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
constant: false
is: C08277
type: Species
is: HMDB00792
has only substance units: false
boundary condition: false
name: trans2,6dodecadienoylcoa
is: SBO:0000247

metaM 5eipencoa m
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
name: 5,8,11,14,17-eicosapentenoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790

metaM glyald c
is: HMDB01051
has only substance units: false
name: D-Glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
boundary condition: false
initial amount: NaN
is: CHEBI:17378
initial concentration: 1.0
type: Species
is: C00577
is: SBO:0000247
constant: false

metaM pi x
has only substance units: false
name: hydrogenphosphate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:43474
type: Species
is: HMDB00973

metaR URIK1
product: MODEL1310110051#
name: uridine kinase (ATP:Uridine)
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
fast: false

metaM cytd m
initial amount: NaN
initial concentration: 1.0
is: HMDB00089
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
is: CHEBI:17562
is: SBO:0000247
name: cytidine
has only substance units: false
boundary condition: false
constant: false

metaR DHORD9
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.5.2
is: SBO:0000185
reactant: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
name: dihydoorotic acid dehydrogenase (quinone10)
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110051#

metaM omhpal r
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: w-hydroxypalmiticacid
notes: FORMULA: C16H30O3 CHARGE: -1
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB06294

metaM etfrd m
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: RH2 CHARGE: 0
type: Species
is: HMDB00145
is: SBO:0000247
name: Electron transfer flavoprotein reduced
is: CHEBI:17263
has only substance units: false
boundary condition: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR G14Tg
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000269
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110051#
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_a534fdc2_c0de_405a_be63_3b2202a7f8fc
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PKLR
is: SBO:0000252
is encoded by: hsa:5313
type: Species

metaR PUNP7
reversible: true
name: purine-nucleoside phosphorylase (Xanthosine)
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is described by: ECO:0000269
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110051#

metaR RETFA
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000
name: retinol acyltransferase
type: Reaction
product: MODEL1310110051#
is: SBO:0000176
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR GGH 6THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110051#
name: Gamma-glutamyl hydrolase (6THF), extracellular
kinetic law: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_2fa6a054_90aa_4539_93b8_ab39b883ab97
constant: false
initial concentration: NaN
name: NDUFB4
is: SBO:0000252
is encoded by: hsa:4710
has only substance units: false
initial amount: NaN
is: O95168
type: Species
boundary condition: true

metaR r0392
reversible: true
product: MODEL1310110051#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110051#

metaR r1886
fast: false
modifier: MODEL1310110051#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110051#
type: Reaction

metaR r0514
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
reactant: MODEL1310110051#
type: Reaction
reversible: false
modifier: MODEL1310110051#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_cb9265f7_aa56_4c34_8c6e_b03ba8cf830f
name: ALDH3B1
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:221
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P43353

metaR RE3567C
fast: false
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
name: RE3567

metaR PUNP6
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
kinetic law: MODEL1310110051#
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110051#
name: purine-nucleoside phosphorylase (Deoxyinosine)
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110051#

metaR ATP1ter
name: ADP/ATP transporter, endoplasmic reticulum
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_3e4d9775_8ab5_4ad4_a8c4_33313ca00d75
is: G3XAJ0
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: ACAD10
initial concentration: NaN
is encoded by: hsa:80724
initial amount: NaN
boundary condition: true

metaR TCHOLAt2
reversible: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
reactant: MODEL1310110051#
fast: false
is: SBO:0000185
name: taurocholate transport via sodium cotransport
modifier: MODEL1310110051#
product: MODEL1310110051#
type: Reaction

metaR r0391
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
reversible: true
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
fast: false
reactant: MODEL1310110051#

metaR ILEt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
name: Isoleucine mitochondrial transport
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_fe56ced6_eaf5_41a7_b3b1_fa4d4c022ea5
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: Q13956
name: PDE6H
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5149
initial amount: NaN

metaM c81crn e
initial concentration: 1.0
constant: false
name: octenoyl carnitine
type: Species
is: HMDB13324
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H27NO4 CHARGE: 0
initial amount: NaN

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR r1497
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110051#
reactant: MODEL1310110051#
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_b35d6923_21d7_4a14_97d4_6c79e965799e
type: Species
is: SBO:0000252
has only substance units: false
name: ECH1
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1891
constant: false
is: Q13011

metaR OROTGLUt
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
name: OROTGLUt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_43556892_af89_411c_a8a5_f481ebdf7a95
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: CHST1
is encoded by: hsa:8534
initial amount: NaN
is: O43916
has only substance units: false

metaM ksi pre13 g
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
type: Species
name: keratan sulfate I biosynthesis, precursor 13
has only substance units: false
is: C00130

metaR FAS140COA
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
product: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110051#
type: Reaction
is: SBO:0000176
name: fatty-acyl-CoA synthase (n-C14:0CoA)
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_c31b088c_dd3f_47ae_8ffb_51b8f3f9f8ef
has part: O43837
has only substance units: false
is: SBO:0000297
name: IDH3A:IDH3B:IDH3G
boundary condition: true
type: Species
has part: P51553
constant: false
is encoded by: hsa:3421
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3420

http://identifiers.org/biomodels.db/MODEL1310110051#_4019a0d0_8186_40c9_b12f_f71e187e1249
initial concentration: NaN
name: SLC2A9
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:56606
initial amount: NaN
type: Species
has only substance units: false

metaR r0390
reactant: MODEL1310110051#
is: SBO:0000176
type: Reaction
reversible: true
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110051#

metaR RE3272N
is: SBO:0000176
reactant: MODEL1310110051#
name: RE3272
kinetic law: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
product: MODEL1310110051#
fast: false
is described by: ECO:0000000
type: Reaction

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_b3572282_2a9d_45a0_a252_85e7a36f1ee7
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110051#_e50d5a84_6ac5_47e1_8812_acd110934c51
is encoded by: hsa:10317
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: B3GALT5
has only substance units: false

metaR TTDCRNt
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110051#

metaR NAGAly
modifier: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.49
reactant: MODEL1310110051#
is described by: ECO:0000269
name: N-acetylgalactosaminidase, alpha-
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reversible: false
fast: false

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR LNELDCCPT1
type: Reaction
fast: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
reversible: false
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

metaR PEPCKm
name: Phosphoenolpyruvate carboxykinase (GTP)
reversible: false
fast: false
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.1.1.32
reactant: MODEL1310110051#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR r0512
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000176

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR PYRt2m
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
name: pyruvate mitochondrial transport via proton symport
kinetic law: MODEL1310110051#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
modifier: MODEL1310110051#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_da7b4417_0b93_4d96_9e03_ff323a7539a3
type: Species
initial amount: NaN
is encoded by: hsa:51727
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: CMPK1
is: B2R6S5
is: SBO:0000252

metaM CE5120 m
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
boundary condition: false
is: CHEBI:57923
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: trans-2-cis-8-tetradecadienoyl-CoA
is: SBO:0000247

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM c81crn c
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H27NO4 CHARGE: 0
is: HMDB13324
is: SBO:0000247
name: octenoyl carnitine
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_df30f31c_61c1_4290_a162_fb04d9181dc3
type: Species
name: SLC12A6
is: Q9UHW9
is encoded by: hsa:9990
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM ksi deg30 l
has only substance units: false
name: keratan sulfate I, degradation product 30
initial concentration: 1.0
is: CHEBI:12936
type: Species
is: HMDB00143
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR LNELDCCPT2
modifier: MODEL1310110051#
type: Reaction
reversible: false
reactant: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176

metaR NACHEX10ly
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110051#

metaR EX ddecrn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaR PYRt2p
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
modifier: MODEL1310110051#
is: SBO:0000185
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
reversible: true
is described by: ECO:0000269
name: pyruvate peroxisomal transport via proton symport
kinetic law: MODEL1310110051#

metaM ksi deg11 l
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
name: keratan sulfate I, degradation product 11
is: HMDB00143
constant: false
is: CHEBI:12936
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR BDMT L
modifier: MODEL1310110051#
is described by: ECO:0000000
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.142
product: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ae2351d4_d7a4_41d0_95fa_f002677161fd
has only substance units: false
is: P23434
constant: false
type: Species
name: GCSH
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2653
boundary condition: true
is: SBO:0000252

metaR r1492
product: MODEL1310110051#
reversible: false
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#
fast: false

metaR CYSASNNaEx
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false
product: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_eaff2a5e_dc7d_40b6_9f59_5bbd5584383f
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: ALG8
is encoded by: hsa:79053

http://identifiers.org/biomodels.db/MODEL1310110051#_bf836b12_f002_4445_afbc_4a4e95d1f609
is: P33402
is encoded by: hsa:2977
initial amount: NaN
has only substance units: false
name: GUCY1A2
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaR PUNP3
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
name: purine-nucleoside phosphorylase (Guanosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176

metaR HSD17B8r
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
name: 17-beta-hydroxysteroid dehydrogenase
type: Reaction
reactant: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (3294.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES:microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ
fast: false
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.62
is described by: ECO:0000269

metaM zymstnl r
is: CHEBI:16608
initial concentration: 1.0
name: 5alpha-cholest-8-en-3beta-ol
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06841
type: Species

metaR G6PDH2rer
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
product: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaM cholcoar x
is: CHEBI:58677
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial amount: NaN
boundary condition: false
type: Species
is: HMDB02178

http://identifiers.org/biomodels.db/MODEL1310110051#_39b26495_db3d_432b_9737_ed1ad93e3ae0
is encoded by: hsa:7360
name: UGP2
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR INSTt2r
modifier: MODEL1310110051#
name: inositol transport in via proton symport
reversible: true
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reactant: MODEL1310110051#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110051#_abf07360_6b2a_4945_9f0d_64966e21ded0
initial amount: NaN
is: O95528
type: Species
boundary condition: true
name: SLC2A10
is encoded by: hsa:81031
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r1150
name: Facilitated diffusion
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000

metaR SERASNNaEx
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110051#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
product: MODEL1310110051#
modifier: MODEL1310110051#

metaR HSD3A1r
is described by: ECO:0000269
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ

metaM ksi deg34 l
name: keratan sulfate I, degradation product 34
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57455
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
is: HMDB01354
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

metaM gal l
type: Species
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: D-galactose
is: HMDB00143
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_f29f059f_310d_48ee_8272_c1e3895d7f7c
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:10195
initial amount: NaN
constant: false
name: ALG3
is: SBO:0000252

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: RE3524
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
fast: false

metaR OCT11EFATP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaM hco3 e
is: HMDB00595
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate
has only substance units: false
is: C00288
boundary condition: false
is: CHEBI:17544

metaM succ e
has only substance units: false
is: HMDB00254
type: Species
initial amount: NaN
name: succinate(2-)
is: CHEBI:30031
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR GALNTg
product: MODEL1310110051#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
name: GalNAc transferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.41

metaR r0517
is: SBO:0000176
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
modifier: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
reversible: true

metaR r0202
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8

http://identifiers.org/biomodels.db/MODEL1310110051#_426bda95_e2a5_4401_ba22_03509b1e4f01
constant: false
name: FOLR1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_3560a130_cc81_40f1_a063_9c043a1c6e23
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5631
type: Species
boundary condition: true
is: P60891
initial concentration: NaN
initial amount: NaN
constant: false
name: PRPS1

metaR r0394
product: MODEL1310110051#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:

metaR PYRt2r
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
name: pyruvate reversible transport via proton symport
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185

metaM leuleu e
constant: false
initial amount: NaN
name: Leucylleucine
type: Species
has only substance units: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/94244
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR PUNP1
kinetic law: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110051#
fast: false
name: purine-nucleoside phosphorylase (Adenosine)
reversible: true
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR 5ADTSTSTERONESte
product: MODEL1310110051#
name: sulfonated testosterone transport
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_dfa2243f_f880_46c7_9a23_48a773bd2840
is: O15056
constant: false
boundary condition: true
type: Species
is encoded by: hsa:8871
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SYNJ2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_2d4dadb1_11ec_4ea6_8a93_e974afa76834
type: Species
is: Q9UMR5
name: PPT2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:9374
boundary condition: true

metaM dolp L c
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
is: SBO:0000247
constant: false
name: dolichyl phosphate(2-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

metaM dmpp x
is: CHEBI:57623
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: HMDB01120
name: prenyl diphosphate(3-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR C161CRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
reversible: false
is: SBO:0000185
product: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
is described by: ECO:0000000
name: C161 transport into the mitochondria
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_6ebee069_0475_4669_b56e_22ded2a4e69f
is encoded by: hsa:54187
initial concentration: NaN
is: Q9NR45
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: NANS
constant: false

metaR HS1ly
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false

metaR r0629
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110051#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.22
reactant: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
modifier: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0f58866d_eb8f_4533_be64_48987208ba6a
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: Q9NTN3
type: Species
name: SLC35D1
is: SBO:0000252
is encoded by: hsa:23169

metaR r0393
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110051#

metaM L2aadp6sa c
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17917
name: L-allysine
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR RE1523M
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: true
name: RE1523
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR GASNASEly
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110051#
is: SBO:0000176
name: glycosylasparaginase, lysosomal
type: Reaction
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110051#

metaM succ c
boundary condition: false
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Succinate
initial concentration: 1.0
is: HMDB00254
type: Species
is: C00042

metaR OCTDECE1CRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaM xoltetrol c
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial concentration: 1.0
is: HMDB01231
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17278
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

http://identifiers.org/biomodels.db/MODEL1310110051#_3d4f5e10_0d0a_4140_8265_184ceff33b80
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AL050025_1_c
is encoded by: hsa:AL050025
is: SBO:0000252
boundary condition: true
type: Species

metaR r0627
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
fast: false

metaM ksii core2 deg5 l
initial amount: NaN
type: Species
is: HMDB00143
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 5
constant: false

metaM 4ppan c
initial amount: NaN
is: CHEBI:10986
type: Species
name: D-4'-Phosphopantothenate
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: HMDB01016
is: C03492

metaR RE1533M
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
type: Reaction
name: RE1533
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true

metaR r1773
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: false
product: MODEL1310110051#
is: SBO:0000185
modifier: MODEL1310110051#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR PPItm
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reactant: MODEL1310110051#
name: diphopshate transporter, mitochondrial
product: MODEL1310110051#
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110051#

metaM ksi deg19 l
is: HMDB01354
boundary condition: false
constant: false
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
initial concentration: 1.0
is: CHEBI:57455
has only substance units: false
type: Species
name: keratan sulfate I, degradation product 19
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_d158aec0_e1f8_4b36_8b1a_c394474a8725
has only substance units: false
type: Species
constant: false
name: LPGAT1
is encoded by: hsa:9926
is: SBO:0000252
initial amount: NaN
is: Q92604
initial concentration: NaN
boundary condition: true

metaM sebcoa x
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: sebacoylcoa
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
type: Species
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110051#_9d7f19a9_7b77_4021_9bb6_1e34eab9cba7
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: AK5
is encoded by: hsa:26289

metaR ETHAK
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.32
is version of: http://identifiers.org/ec-code/2.7.1.82
name: Ethanolamine kinase
reversible: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#

metaM cdpdag hs c
constant: false
is: CHEBI:58332
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial amount: NaN
is: SBO:0000247
name: CDP-diacylglycerol(2-)
boundary condition: false

metaR CORE4GTg
kinetic law: MODEL1310110051#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110051#
type: Reaction
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false

metaM leuleu c
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
name: Leucylleucine
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H24N2O3 CHARGE: 0

metaR H2O2t
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
kinetic law: MODEL1310110051#
name: hydrogen peroxide transport via diffusion
fast: false
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR MECOAS1m
name: mesaconate--CoA ligase (GDP-forming)
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is: SBO:0000176
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000304
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_651fa511_dfa6_4943_834b_66e33b40f2d3
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80347
name: COASY
has only substance units: false
constant: false
is: Q13057

metaM octe5coa m
initial concentration: 1.0
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false
type: Species
name: 5-octenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false

metaR FAOXTC162TC142m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaM hexdiac r
has only substance units: false
type: Species
name: hexadecanediocacid
boundary condition: false
is: SBO:0000247
is: C08260
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C16H28O4 CHARGE: -2
is: HMDB00672

metaM eitetcoa m
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 5,8,11,14-eicosatetraenoylcoa
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_1f502182_02db_4531_9c4e_c7913fbe300e
initial amount: NaN
boundary condition: true
is encoded by: hsa:4694
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFA1
is: Q6IBB5
constant: false
is: SBO:0000252

metaM hs deg6 l
is: HMDB01352
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
is: CHEBI:17180
name: heparan sulfate, degradation product 6
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_58cf298e_772e_4959_a711_712d41cc32a8
type: Species
is encoded by: hsa:728441
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: GGT2
is: SBO:0000252

metaM s2l2n2m2masn l
is: CHEBI:18287
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00174
notes: FORMULA: C84H135N6O61X CHARGE: -2
constant: false
name: de-Fuc form of PA6
is: SBO:0000247
type: Species
has only substance units: false

metaR DOCO13EFATP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR r2308
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000185
reversible: true

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR r1377
reactant: MODEL1310110051#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
kinetic law: MODEL1310110051#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000000

metaM hyptaur c
is: SBO:0000247
is: CHEBI:16668
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
name: Hypotaurine
boundary condition: false
has only substance units: false
is: HMDB00965
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR LPCOXp
modifier: MODEL1310110051#
product: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.3.1
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
type: Reaction
name: L-pipecolate oxidase, peroxisomal
kinetic law: MODEL1310110051#
is described by: ECO:0000269

metaR RBFK
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
name: riboflavin kinase
product: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.26
kinetic law: MODEL1310110051#
is described by: ECO:0000269
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_18723596_335e_400e_bd82_754542a0cf76
has only substance units: false
initial amount: NaN
is encoded by: hsa:5330
type: Species
constant: false
name: PLCB2
is: SBO:0000252
initial concentration: NaN
is: Q59F77
boundary condition: true

metaM forglu c
has only substance units: false
is: SBO:0000247
is: HMDB00854
initial concentration: 1.0
constant: false
name: N-Formimidoyl-L-glutamate
type: Species
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: CHEBI:18327
initial amount: NaN
boundary condition: false
is: C00439

http://identifiers.org/biomodels.db/MODEL1310110051#_e6e7aa6c_a1b8_4393_92d7_f4400299d115
type: Species
initial concentration: NaN
is encoded by: hsa:56301
name: SLC7A10
boundary condition: true
is: Q9NS82
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaM mev R x
initial amount: NaN
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: CHEBI:36464
name: (R)-mevalonate
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB00227

metaR r1378
kinetic law: MODEL1310110051#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
product: MODEL1310110051#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reactant: MODEL1310110051#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR HSD17B42x
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
name: hydroxysteroid (17-beta) dehydrogenase 4
is: SBO:0000176
reversible: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_becd5921_24f8_4e39_a896_8b99589ca3ab
initial amount: NaN
name: MYO5B
is encoded by: hsa:4645
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9H6Y6
constant: false
has only substance units: false
type: Species

metaR CRNCARtp
kinetic law: MODEL1310110051#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110051#
name: carnitine-acetylcarnitine carrier, peroxisomal
fast: false
reactant: MODEL1310110051#

metaM ksi pre26 g
name: keratan sulfate I biosynthesis, precursor 26
boundary condition: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
is: SBO:0000247
is: CHEBI:28067
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR M1316Mg
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
type: Reaction
product: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.114

http://identifiers.org/biomodels.db/MODEL1310110051#_77f1000b_ade3_4013_822a_61e18d9e1191
constant: false
is encoded by: hsa:AI926493
has only substance units: false
boundary condition: true
initial amount: NaN
name: _AI926493_1_c
type: Species
initial concentration: NaN
is: SBO:0000252

metaR CBASPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000134
name: Transport of N-carbamoyl-L-aspartate

metaR SARCStm
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
name: Sarcosine transport (mitochondrial)
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction

metaR r2506
reversible: true
reactant: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
name: Utilized transport

metaM ksi deg8 l
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
boundary condition: false
constant: false
is: CHEBI:12936
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 8
initial amount: NaN

metaR GLUDxm
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110051#
reversible: true
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
name: glutamate dehydrogenase (NAD) (mitochondrial)

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110051#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110051#

metaM met L e
is: HMDB00696
initial concentration: 1.0
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16643
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_d3c54ebc_f480_4e7c_9b28_cef88f83f809
is: P30838
has only substance units: false
constant: false
is encoded by: hsa:218
type: Species
initial amount: NaN
boundary condition: true
name: ALDH3A1
initial concentration: NaN
is: SBO:0000252

metaR MG3er
type: Reaction
fast: false
reactant: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_1b55c44b_4a52_4f69_9394_d038e7c19537
is encoded by: hsa:3419
constant: false
name: IDH3A:IDH3B:IDH3G
has part: E9PDD5
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
has part: P50213
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:3420
is encoded by: hsa:3421

metaM ksi pre20 g
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 20

http://identifiers.org/biomodels.db/MODEL1310110051#_a1d2338f_a51c_41b6_8f7a_3febdf903975
has only substance units: false
name: DHCR24
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:1718
initial amount: NaN
type: Species
initial concentration: NaN
is: Q15392

metaM 2mb2coa m
initial amount: NaN
boundary condition: false
is: HMDB02054
is: SBO:0000247
constant: false
name: 2-methylcrotonoyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57337
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
has only substance units: false

metaR SO4tl
reversible: true
name: Sulfate transport (lysosome)
type: Reaction
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110051#_65682095_f76c_4d36_975b_cf2431301c4e
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
name: _BE966236_1_c
is encoded by: hsa:BE966236

metaM 5aop m
constant: false
is: C00430
name: 5-Amino-4-oxopentanoate
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17549
initial concentration: 1.0
is: HMDB01149
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
boundary condition: false

metaM Asn X Ser Thr r
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
constant: false
has only substance units: false
is: C01342
is: SBO:0000247
name: protein-linked asparagine residue (N-glycosylation site)
is: HMDB00051
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:28938

metaR r2309
is: SBO:0000185
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110051#
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110051#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_504c2819_3d6d_4113_8c02_bd9a0365073a
type: Species
is encoded by: hsa:6582
has only substance units: false
boundary condition: true
name: SLC22A2
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR OCDCAtr
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM succ m
constant: false
name: Succinate
initial amount: NaN
is: C00042
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:30031

metaM L2aadp6sa m
is: CHEBI:17917
is: HMDB01263
boundary condition: false
name: L-allysine
has only substance units: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC9C7m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaR RTOTAL2t
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: RTOTAL2 transport
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_58a5210c_f28e_40a9_b8fa_6c541eddb80f
name: SLC24A4
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:123041

metaR DIDPtn
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
name: dIDP nuclear transport
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
fast: false

metaM hco3 m
initial concentration: 1.0
name: Bicarbonate
initial amount: NaN
has only substance units: false
is: CHEBI:17544
is: SBO:0000247
boundary condition: false
constant: false
is: C00288
type: Species
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

http://identifiers.org/biomodels.db/MODEL1310110051#_b5f6faee_d74b_4828_a0dd_dcb90d2cceac
boundary condition: true
type: Species
name: AADAT
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51166
constant: false
has only substance units: false
is: Q8N5Z0

metaR LEUTAm
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: leucine transaminase, mitochondrial
reversible: true
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM met L c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
is: HMDB00696
name: L-methionine
is: CHEBI:16643
has only substance units: false
boundary condition: false

metaM fdp c
constant: false
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16905
type: Species
name: D-Fructose 1,6-bisphosphate
is: HMDB01058
is: C00354

metaR RE3347C
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: true
name: RE3347
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaM cholcoar r
type: Species
constant: false
boundary condition: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: HMDB02178
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:58677
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR FAOXC16180m
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
type: Reaction
is described by: ECO:0000269
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_432720aa_d504_498e_9095_02f152bccbf7
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:9843
name: HEPH
is: E9PHN8
initial concentration: NaN

metaM octdececoa m
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
name: octadecenoylcoa
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM c10dc x
boundary condition: false
constant: false
name: sebacoyl carnitine
is: HMDB00651
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C17H30NO6 CHARGE: -1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b0652c5a_380c_4923_99fc_4f70a091b078
constant: false
is: SBO:0000252
is: O60488
is encoded by: hsa:2182
type: Species
name: ACSL4
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_8d6c2a78_dbc5_4878_a101_46c07318bc77
initial amount: NaN
name: BCKDHB
type: Species
is: SBO:0000252
is encoded by: hsa:594
boundary condition: true
initial concentration: NaN
is: P21953
constant: false
has only substance units: false

metaM HC01104 e
is: CHEBI:61146
has only substance units: false
constant: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
name: 4-nitrophenyl phosphate(2-)
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR ALAASNNaEx
kinetic law: MODEL1310110051#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
reversible: false
reactant: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
fast: false
product: MODEL1310110051#
type: Reaction

metaR GBGT1
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (26301.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.88 Confidence Level: 4 AUTHORS: PMID:10506200 NOTES:NJ
type: Reaction
name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.88
is: SBO:0000176
reversible: false
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269

metaR C181CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
fast: false
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000176
name: transport of Octadecenoyl-CoA into mitochondrial matrix
kinetic law: MODEL1310110051#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_e4de054a_2c3e_4126_b19d_5b58278b2340
is encoded by: hsa:763
name: CA5A
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P35218

metaR PPItr
product: MODEL1310110051#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction
is: SBO:0000185
reactant: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_9016df81_7f35_44a5_92c1_6a336b493e11
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:158
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ADSL
boundary condition: true

metaR TIGCRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_b263e297_a993_46c0_acc9_2992a46e2aa5
type: Species
is encoded by: hsa:4704
is: SBO:0000252
is: Q16795
name: NDUFA9
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaR r0620
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.7
reversible: true
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:

metaR r1156
reversible: true
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
fast: false
is: SBO:0000176
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is described by: ECO:0000000
reactant: MODEL1310110051#

metaR ARACHCRNt
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_418e5647_1e3f_4a36_be03_edd44894a2bf
is: Q8TDB8
constant: false
is: SBO:0000252
initial concentration: NaN
name: SLC2A14
is encoded by: hsa:144195
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR DOLMANP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
name: dolichol-phosphate mannose flippase (liver)
product: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#

metaM ha pre1 l
is: SBO:0000247
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
constant: false
is: CHEBI:16126
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: hyaluronan biosynthesis, precursor 1

http://identifiers.org/biomodels.db/MODEL1310110051#_b49fa8a1_bd59_4326_9cc9_745b6ec7a3de
name: DPM2
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:8818
type: Species
is: SBO:0000252
boundary condition: true

metaR C181CPT1
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
type: Reaction
reversible: false
reactant: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
modifier: MODEL1310110051#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
kinetic law: MODEL1310110051#

metaR BACCL
reversible: false
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
name: biotin-[acetyl-CoA-carboxylase] ligase
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_aec484ba_8512_44fa_a73f_db6af2ff37c1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O95427
type: Species
name: PIGN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23556
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a7761894_5a7c_4762_865d_203d628f727e
initial amount: NaN
name: SLC4A9
boundary condition: true
constant: false
is encoded by: hsa:83697
is: SBO:0000252
is: E9PDK1
has only substance units: false
initial concentration: NaN
type: Species

metaM xoltetrol m
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01231
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: CHEBI:17278
is: SBO:0000247
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial concentration: 1.0

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR EX decdicrn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_3f122e75_60db_493d_8ba8_ed3cff7bf159
name: ACO2
is: Q99798
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:50
type: Species
has only substance units: false
initial concentration: NaN

metaM coa l
type: Species
is: HMDB01423
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57287
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: coenzyme A(4-)

metaR r1907
type: Reaction
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
modifier: MODEL1310110051#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_03a5809b_6f29_47bd_9ab5_f19bd1a66c5f
initial concentration: NaN
is encoded by: hsa:1545
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q16678
constant: false
name: CYP1B1

metaR FATP5t
reactant: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
name: fatty acid electroneutral transport
reversible: true
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110051#

metaR GLYSNAT5tc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM ksii core4 deg3 l
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 3
is: SBO:0000247
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: CHEBI:12936
type: Species
is: HMDB00143

metaR r0630
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.1
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000000
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_de966949_6063_430d_92b2_e96fbec10ba1
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: CA7
is encoded by: hsa:766
initial concentration: NaN
is: Q86YU0
boundary condition: true
is: SBO:0000252

metaR ACITL
modifier: MODEL1310110051#
name: ATP-Citrate lyase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.3.8
reversible: false
type: Reaction
product: MODEL1310110051#
fast: false
is: SBO:0000176

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_0de7f46a_8544_430a_a8c1_2abb8331f74d
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:9488
is: Q92521
name: PIGB
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_628272d2_12af_4b51_aab6_69ed0fa5d245
is: O95498
initial amount: NaN
constant: false
has only substance units: false
name: VNN2
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8875

metaM 3php c
type: Species
name: 3-phosphonatooxypyruvate(3-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
initial amount: NaN
is: CHEBI:18110
constant: false
is: HMDB01024

metaM coa m
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
is: HMDB01423
name: Coenzyme A
initial concentration: 1.0
is: CHEBI:57287
type: Species
is: C00010
boundary condition: false
is: SBO:0000247

metaR BALAtmr
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: Beta-alanine reversible mitochondrial transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reversible: true
reactant: MODEL1310110051#
fast: false
type: Reaction
product: MODEL1310110051#

metaM 5aizc c
initial concentration: 1.0
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: C04751
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: CHEBI:58564
type: Species
is: HMDB06273
has only substance units: false

metaR EX c5dc
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR PDE4n
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: false
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
is version of: http://identifiers.org/ec-code/3.1.4.35

metaR C101CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaR RE3002X
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
kinetic law: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
name: RE3002
is described by: ECO:0000000
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176

metaR FUCASE2ly
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
name: alpha-fucosidase, lysosomal
fast: false
kinetic law: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51

metaR ACETONEt2
modifier: MODEL1310110051#
is described by: ECO:0000269
name: acetone transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
fast: false
reversible: true

metaR Coqe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: Transport of q10
product: MODEL1310110051#
is described by: ECO:0000134
reversible: true
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false

metaR PItx
kinetic law: MODEL1310110051#
is: SBO:0000185
name: Phosphate transporter, peroxisome
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#

metaM 34dhpha c
constant: false
name: (3,4-dihydroxyphenyl)acetate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17612
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
type: Species
is: HMDB01336
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_4a87c7f0_7e8b_46fb_8fd8_d405932cc7db
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:D29675
name: _D29675_1_e

http://identifiers.org/biomodels.db/MODEL1310110051#_69582a23_3fdb_4f21_992e_4d5070887c4b
is: SBO:0000252
name: TXNRD1
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:7296
is: Q16881
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_ce94e7e5_ab5e_4818_8644_858ce75515cf
has only substance units: false
name: GGT2
is encoded by: hsa:728441
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM duri n
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: 2'-deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
is: HMDB00012
type: Species
boundary condition: false
is: CHEBI:16450

metaM 3octdece1coa m
has only substance units: false
name: 3-hydroxyoctadecenoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/5280355
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
boundary condition: false

metaR LPSe
name: lipase
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (3990.1) or (9388.1) or (5407.1) or (8513.1) or (5408.1) or (5406.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:10318835,PMID:1379598,PMID:1783385,PMID:2753032,PMID:3304425 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is: SBO:0000176
reversible: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110051#
is described by: ECO:0000000

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaR S2TASE2ly
name: iduronate-2-sulfatase, lysosomal
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.13
is described by: ECO:0000000
is: SBO:0000176

metaM cs b deg1 l
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57455
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01354
initial concentration: 1.0

metaM Asn X Ser Thr l
is: HMDB00051
name: protein-linked asparagine residue (N-glycosylation site)
is: C01342
is: SBO:0000247
constant: false
is: CHEBI:28938
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: XH CHARGE: 0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_f69b899e_44c0_4c1b_9637_4452f35c4188
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_m
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR PRFGS
type: Reaction
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylformylglycinamidine synthase
kinetic law: MODEL1310110051#
reversible: false
product: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.3
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ffe0d8c4_9df8_4cb7_9649_9b1b4d4530b6
name: VNN3
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55350
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f04353a1_cb3e_4465_84ba_cd9748897176
name: SLC26A9
is: B3KXK1
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:115019
initial concentration: NaN

metaR FAOXC260240x
is: SBO:0000176
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM 3decdicoa m
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
name: 3,7-decadienoylcoa
boundary condition: false

metaM imp c
boundary condition: false
name: IMP
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00175
is: C00130
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: CHEBI:58053
initial concentration: 1.0
type: Species
has only substance units: false

metaR CSPG Btly
reversible: false
name: chondroitin sulfate B transport, extracellular to lysosome
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_72246487_94d3_4685_95cb_2d9d1db1031d
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: FTMT
is: Q8N4E7
initial amount: NaN
is encoded by: hsa:94033

metaR BTNDm
is version of: http://identifiers.org/ec-code/3.5.1.12
product: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
reversible: false
name: biotinidase (biotin), mitochondrial
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
fast: false
type: Reaction
is: SBO:0000176

metaR PPItx
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
type: Reaction
name: Diphosphate transporter, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110051#_3e58904a_d1b7_4159_9de7_25de8366c189
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110051#_426fc354_2993_4354_abe1_bd0014772239
boundary condition: true
constant: false
is: P20594
type: Species
initial concentration: NaN
is encoded by: hsa:4882
initial amount: NaN
name: NPR2
has only substance units: false
is: SBO:0000252

metaR GALASE5ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR FAOXC15C13m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR G14T3g
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaM vacccrn m
type: Species
name: Vaccenyl carnitine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06351
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d08e9f22_4e98_432b_b901_ddfce13be477
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: PDE9A
is encoded by: hsa:5152
initial amount: NaN

metaM l2n2m2mn l
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
notes: FORMULA: C54H91N3O41 CHARGE: 0
type: Species
boundary condition: false
is: HMDB00143
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
constant: false

metaM leuktrA4 c
constant: false
type: Species
boundary condition: false
is: CHEBI:57463
name: leukotriene A4(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337

http://identifiers.org/biomodels.db/MODEL1310110051#_63b4e3d7_d7fe_41f8_826c_49f7d1575151
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5464
name: PPA1
type: Species
is: Q15181
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_977908fb_70c8_4fa7_ae3e_8f47178e4505
name: SMPD3
initial amount: NaN
is encoded by: hsa:55512
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: A8K0T6
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_60953f15_19ce_4c67_9486_b8eae1aa3fb8
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55350
is: SBO:0000252
name: VNN3
constant: false
initial amount: NaN

metaM coa r
constant: false
initial amount: NaN
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: C00010
boundary condition: false
is: HMDB01423
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_3d506398_eb7e_4836_8ec5_1dcc4f6d5a01
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:M68895
has only substance units: false
initial concentration: NaN
name: _M68895_1_c

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM coa n
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
name: coenzyme A(4-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR M8MASNterg
name: m8masn transport from ER to Golgi apparatus
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD

metaM pap c
is: CHEBI:58343
is: HMDB00061
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: adenosine 3',5'-bismonophosphate(4-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR G6PDH2r
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.49 Confidence Level: 0 AUTHORS: NOTES:JLR - a reversible reaction that is otherwise identical to ZWF
name: glucose 6-phosphate dehydrogenase
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.49
product: MODEL1310110051#
reversible: true
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110051#
fast: false

metaM ppa c
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB00237
name: propionate
is: CHEBI:17272

http://identifiers.org/biomodels.db/MODEL1310110051#_a06f9eaa_e9be_45fe_933f_4994f792cf04
constant: false
initial amount: NaN
has only substance units: false
is: Q9Y217
is encoded by: hsa:9107
type: Species
boundary condition: true
name: MTMR6
is: SBO:0000252
initial concentration: NaN

metaR FATP7t
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110051#
fast: false
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaM arachdcrn m
is: HMDB01322
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57387
name: C20:4 carnitine
type: Species

metaM ttdcrn c
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: tetradecanoyl carnitine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
is: http://identifiers.org/pubchem.compound/3413344
is: HMDB05066
is: SBO:0000247

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_1b022224_dd06_426a_b9f7_2b82895739c9
is: SBO:0000252
is encoded by: hsa:280
is: P19961
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: AMY2B
initial concentration: NaN

metaM HC01162 c
boundary condition: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: CHEBI:58376
type: Species
constant: false

metaR APAT2rm
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.19
type: Reaction
fast: false
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
is described by: ECO:0000212
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110051#

metaM leuktrA4 e
type: Species
is: CHEBI:57463
boundary condition: false
name: leukotriene A4(1-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01337
constant: false
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaM ppa e
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17272
name: propionate
is: HMDB00237
has only substance units: false
initial concentration: 1.0
constant: false

metaM n2m2mn l
notes: FORMULA: C42H71N3O31 CHARGE: 0
has only substance units: false
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:17588
constant: false
is: HMDB00742
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_8338d415_4cf2_492e_9ed1_e7fccad83864
boundary condition: true
is encoded by: hsa:4696
is: O95167
name: NDUFA3
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_8f8f26a0_fe48_4bd5_926d_226ba5eb1e34
has only substance units: false
initial amount: NaN
is encoded by: hsa:126
is: P00326
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: ADH1C
initial concentration: NaN

metaR SIAASE3ly
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110051#_4313b43c_613b_4576_9c83_c4fa1003c35f
name: ADH1A:ADH1B
initial concentration: NaN
type: Species
is: SBO:0000297
has part: P07327
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:124
initial amount: NaN

metaR PIter
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000212
name: phosphate transport, endoplasmic reticulum
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_9be2c8c0_98fe_4eb5_bf8a_2c343b55838c
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:2108
initial amount: NaN
boundary condition: true
is: P13804
name: ETFA
type: Species
has only substance units: false

metaR r0399
product: MODEL1310110051#
type: Reaction
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#

metaR FAOXC163C164x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR NACHEX17ly
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110051#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#

metaR PItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
name: phosphate transport, nuclear
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_7bd5febe_06d2_4f4c_837c_925487f1b26f
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:T83654
is: SBO:0000252
type: Species
initial concentration: NaN
name: _T83654_1_m

http://identifiers.org/biomodels.db/MODEL1310110051#_fbe7dc2e_7ca0_4ed9_a3a9_9a7e17a458c5
initial concentration: NaN
has only substance units: false
constant: false
is: O60909
type: Species
name: B4GALT2
boundary condition: true
initial amount: NaN
is encoded by: hsa:8704
is: SBO:0000252

metaM prgnlones c
boundary condition: false
is: CHEBI:35420
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
type: Species
name: pregnenolone sulfate
is: HMDB00774

metaM duri c
boundary condition: false
is: HMDB00012
type: Species
initial concentration: 1.0
is: C00526
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
is: SBO:0000247
name: Deoxyuridine
initial amount: NaN
is: CHEBI:16450

metaM hexdiac c
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: C08260
constant: false
is: SBO:0000247
name: hexadecanediocacid
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
initial amount: NaN

metaM pap g
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
is: CHEBI:58343
type: Species
constant: false
has only substance units: false
name: adenosine 3',5'-bismonophosphate(4-)
initial amount: NaN
boundary condition: false
is: HMDB00061
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_f8a5ecb1_3bdc_4074_b27a_dff7e03ddcea
is: P78381
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: SLC35A2
boundary condition: true
type: Species
is encoded by: hsa:7355
initial concentration: NaN

metaM tag hs e
is: CHEBI:17855
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
type: Species
boundary condition: false
initial amount: NaN
name: triglyceride

http://identifiers.org/biomodels.db/MODEL1310110051#_eee61897_3642_472b_90bf_c6da4c6e34b4
type: Species
initial concentration: NaN
name: COX7A1
is encoded by: hsa:1346
constant: false
is: P24310
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_c196879f_8549_46c0_8e57_8c790853b811
boundary condition: true
has only substance units: false
name: ADH1B:ADH1C
constant: false
type: Species
is: SBO:0000297
is encoded by: hsa:126
initial concentration: NaN
has part: P00326
initial amount: NaN

metaR r0934
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_bdd46b5d_6240_4501_9667_dac2350403f5
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: SLC25A1
is encoded by: hsa:6576
type: Species
initial amount: NaN
is: D9HTE9
has only substance units: false

metaR RE1233C
kinetic law: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is: SBO:0000176
is described by: ECO:0000000
name: RE1233
reactant: MODEL1310110051#

metaR DAGK hs
type: Reaction
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107
reactant: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000269
name: Diacylglycerol phosphate kinase (homo sapiens)

metaM nm2masn g
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C42H70N3O30X CHARGE: 0
initial amount: NaN
boundary condition: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
constant: false
is: SBO:0000247
is: C05884

metaM hco3 c
is: SBO:0000247
boundary condition: false
name: Bicarbonate
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
is: HMDB00595
is: CHEBI:17544
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C00288

metaR FAOXC1811603m
type: Reaction
is described by: ECO:0000269
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110051#
fast: false
reversible: false

metaM 3octdece1coa c
type: Species
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxyoctadecenoylcoa
is: HMDB13336
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

metaM ksi deg18 l
is: SBO:0000247
is: HMDB00143
type: Species
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
has only substance units: false
name: keratan sulfate I, degradation product 18
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110051#_334bfc6d_76eb_4192_b6cc_86418a1628df
initial concentration: NaN
initial amount: NaN
is: O00154
constant: false
name: ACOT7
type: Species
is encoded by: hsa:11332
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR LACLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
reactant: MODEL1310110051#
is described by: ECO:0000134
fast: false
is: SBO:0000185
reversible: false
type: Reaction
name: Lactate transport
product: MODEL1310110051#
kinetic law: MODEL1310110051#

metaR RE2079R
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: RE2079
type: Reaction

metaM duri e
is: HMDB00012
boundary condition: false
type: Species
is: C00526
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
is: CHEBI:16450
name: Deoxyuridine

http://identifiers.org/biomodels.db/MODEL1310110051#_c7e0db40_9909_4a35_8865_298148ba93c4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q96T66
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: NMNAT3
is encoded by: hsa:349565

metaR METLEUex
name: Methionine/Leucine exchange (Met in)
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
reversible: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110051#

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR DMNONCRNCPT2
name: DMNONCRNCPT2
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
fast: false

metaR B3GNT39g
kinetic law: MODEL1310110051#
reversible: false
product: MODEL1310110051#
fast: false
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
type: Reaction

metaR MEOHtly
name: Methanol transporter, lysosome
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NCD
product: MODEL1310110051#

metaM 3decdicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3,7-decadienoylcoa
initial amount: NaN
constant: false

metaM tag hs c
is: CHEBI:17855
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
name: triglyceride
boundary condition: false
type: Species

metaR S6T12g
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction

metaM coa c
boundary condition: false
name: Coenzyme A
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
constant: false
is: CHEBI:3312
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01423
initial concentration: 1.0

metaM succ x
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:30031
type: Species
is: HMDB00254
is: C00042
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_392f7ebf_1670_49e4_b8d4_4ef307589565
constant: false
is encoded by: hsa:27165
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: GLS2
initial concentration: NaN

metaM c10dc c
name: sebacoyl carnitine
is: SBO:0000247
initial amount: NaN
is: HMDB00651
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C17H30NO6 CHARGE: -1
boundary condition: false
constant: false

metaR FAOXTC122TC101m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
fast: false
is: SBO:0000176
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110051#
reversible: false

metaR RE3346M
modifier: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: RE3346
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110051#
reversible: true

metaR C40CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_aaf47252_0226_46af_b859_511e154f2a54
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5625
constant: false
boundary condition: true
is: O43272
name: PRODH

http://identifiers.org/biomodels.db/MODEL1310110051#_9e626446_a187_46ee_b20d_8777c5d208a2
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:29968
boundary condition: true
constant: false
name: PSAT1
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_18f009fc_9618_469a_a610_ed11d7c9be4c
boundary condition: true
name: NDUFA10
initial concentration: NaN
is: O95299
has only substance units: false
is encoded by: hsa:4705
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_f6090be6_7df9_47d1_bef8_600ab2d324f9
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q5FC00
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:765
name: CA6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_25219912_8c57_448f_804f_6696d3da642f
is encoded by: hsa:8972
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: MGAM
is: O43451
is: SBO:0000252
constant: false
initial concentration: NaN

metaR FAOXC80
name: Beta oxidation of med/long chain fatty acid
kinetic law: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110051#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110051#_2aa698c9_21c1_4e68_93ca_39e8993281f3
initial amount: NaN
name: HMGCLL1
has only substance units: false
type: Species
is: Q9NT06
constant: false
is encoded by: hsa:54511
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR CYTK7n
fast: false
name: cytidylate kinase (CMP,UTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_66de659f_3595_43e8_975d_14d5a44f3afc
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:26301
has only substance units: false
constant: false
type: Species
boundary condition: true
is: Q8N5D6
initial concentration: NaN
name: GBGT1

metaR PRGNLONESULT
is version of: http://identifiers.org/ec-code/2.8.2.2
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
fast: false
name: steroid sulfotransferase
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.8.2.14

http://identifiers.org/biomodels.db/MODEL1310110051#_d52fc384_94f7_484c_89bc_69fa11610819
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PIGO
constant: false
is encoded by: hsa:84720
type: Species

metaR FAOXC4C4DCc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaM 5dpmev x
type: Species
initial amount: NaN
is: CHEBI:15899
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
is: HMDB01090
name: (R)-5-Diphosphomevalonate

metaR r0937
reactant: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110051#
fast: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_3b18c7ea_9c9a_40e4_b916_df34389f0773
name: ACSL3
constant: false
type: Species
is encoded by: hsa:2181
initial concentration: NaN
is: O95573
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r0522
reactant: MODEL1310110051#
type: Reaction
reversible: false
product: MODEL1310110051#
is: SBO:0000176
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000

metaM arab L e
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:30849
constant: false
boundary condition: false
is: HMDB00646
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
initial amount: NaN

metaM eitetcoa x
boundary condition: false
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
name: 5,8,11,14-eicosatetraenoylcoa
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4

metaM dd2coa c
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB03712
is: SBO:0000247
has only substance units: false
constant: false
name: trans-Dodec-2-enoyl-CoA
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_d52e33e4_0366_4ed0_8682_d11c61d1fddc
has only substance units: false
constant: false
name: GUCY1B2:GUCY1A3
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2982
type: Species
is encoded by: hsa:2974
boundary condition: true
has part: D6RDW3

metaR IMPC
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
modifier: MODEL1310110051#
name: IMP cyclohydrolase

http://identifiers.org/biomodels.db/MODEL1310110051#_9c1e29fb_4776_4885_a33a_47837b695fd1
is: SBO:0000252
is encoded by: hsa:115584
has only substance units: false
initial amount: NaN
name: SLC5A11
is: Q8WWX8
constant: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_9831c2f2_de67_496c_bbbe_9528123c756b
is: P32119
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7001
name: PRDX2
is: SBO:0000252
has only substance units: false

metaM e4p c
constant: false
type: Species
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: SBO:0000247
name: D-Erythrose 4-phosphate
initial concentration: 1.0
is: C00279
is: CHEBI:16897
initial amount: NaN
is: HMDB01321
has only substance units: false
boundary condition: false

metaR S6TASE13ly
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110051#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110051#_513188af_e695_4c74_9649_e285f8033ceb
initial amount: NaN
is: Q8IV97
type: Species
constant: false
initial concentration: NaN
name: SLC7A5
is encoded by: hsa:8140
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR ALDD2xm
product: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
kinetic law: MODEL1310110051#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
is described by: ECO:0000134
reversible: false
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_93e551ab_1a94_46d8_8415_7bed34a18dca
constant: false
boundary condition: true
is encoded by: hsa:8776
name: MTMR1
is: SBO:0000252
has only substance units: false
is: Q13613
initial concentration: NaN
initial amount: NaN
type: Species

metaR C161OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_18522e37_9159_4c3a_8b07_9b10f5fd8798
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: GUK1
is: Q16774
is encoded by: hsa:2987
type: Species
has only substance units: false
initial concentration: NaN

metaR HSD3B7P
type: Reaction
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.181
kinetic law: MODEL1310110051#
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
is described by: ECO:0000269
modifier: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110051#

metaM octe5coa x
is: SBO:0000247
initial amount: NaN
name: 5-octenoylcoa
boundary condition: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
type: Species
constant: false
has only substance units: false

metaR C51CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaR R group phosphotase 1
is described by: ECO:0000000
name: R group phosphotase 1
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2aeb79ac_6233_4b19_a42d_c5d6eb9bccc5
name: NDUFV3
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4731
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_1bb0818a_9d57_4409_bf6c_a6fb3c5cc5af
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8869
constant: false
initial amount: NaN
is: Q9UNP4
has only substance units: false
name: ST3GAL5

metaR H6ET3er
reactant: MODEL1310110051#
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.8.1
fast: false
product: MODEL1310110051#
reversible: false
modifier: MODEL1310110051#
is: SBO:0000176

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110051#
is: SBO:0000176
fast: false
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR r1498
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
is: SBO:0000185
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ba58b8dd_12e9_460d_b236_ee06e4957e78
has only substance units: false
name: AQP8
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:343
type: Species
initial amount: NaN
initial concentration: NaN
is: O94778

metaM arab L c
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
is: SBO:0000247
name: L-arabinose
is: CHEBI:30849
has only substance units: false
type: Species
boundary condition: false
is: HMDB00646
constant: false

metaM mmcoa R m
type: Species
has only substance units: false
constant: false
is: HMDB01269
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57326
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
name: (R)-methylmalonyl-CoA(5-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_cdda3f68_e64d_4ea4_ac14_ed8d4e8b2bbf
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: SLC25A19
is encoded by: hsa:60386
is: Q9HC21
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_4de432b8_320b_436f_9442_5d787c0a30a9
initial concentration: NaN
is encoded by: hsa:55229
is: Q9NVE7
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: PANK4
has only substance units: false

metaM ksi pre23 g
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 23
initial amount: NaN
type: Species
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
constant: false
is: SBO:0000247
is: CHEBI:28067

metaM CE2424 m
initial concentration: 1.0
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
is: SBO:0000247
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
initial amount: NaN
is: HMDB11123
type: Species
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110051#_ed4323df_a1e4_4500_af66_0f66b3977f61
name: SLC13A2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9058
constant: false
has only substance units: false
is: E7ETH5
type: Species

metaM coa g
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01423
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: coenzyme A(4-)
is: CHEBI:57287
is: SBO:0000247
type: Species
boundary condition: false

metaR r0936
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110051#
name: Transport reaction
product: MODEL1310110051#

metaM 3hddcoa c
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: HMDB00623
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_106e59ac_ed3b_41fd_96b1_077b40fe362d
constant: false
is: B3KQV3
name: PIP4K2C
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:79837
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_9b3c20ac_491a_470a_89b1_af9fd8987a9f
has only substance units: false
name: SYNJ1
type: Species
boundary condition: true
is: SBO:0000252
is: C9JFZ1
constant: false
is encoded by: hsa:8867
initial amount: NaN
initial concentration: NaN

metaM q10h2 e
constant: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: Ubiquinol-10

http://identifiers.org/biomodels.db/MODEL1310110051#_60014747_ebfd_483e_bdf9_19e952693dca
type: Species
is encoded by: hsa:5152
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PDE9A
initial amount: NaN
constant: false

metaR PItg
is: SBO:0000185
product: MODEL1310110051#
name: phosphate transport, Golgi apparatus
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaR FAOXC2452253x
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is: SBO:0000176
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) confusing name, sorry - accounting for omega3 vs omega6 FA peroxisomal (very long chain FA) c24:5,n-3 -> c22:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR r2099
modifier: MODEL1310110051#
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_42327bd9_4a69_4f1b_9ef4_6efb0e93aebc
has only substance units: false
is encoded by: hsa:54344
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: DPM3
is: Q9P2X0
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_8fd5d0b2_c9bf_4602_8d73_4f12ceefafd1
initial amount: NaN
is encoded by: hsa:6472
boundary condition: true
name: SHMT2
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: B4DJQ3

metaM ribflv e
is: SBO:0000247
boundary condition: false
name: Riboflavin
initial amount: NaN
is: HMDB00244
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
is: CHEBI:3554
has only substance units: false
is: C00255
constant: false
initial concentration: 1.0

metaR RE3568C
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
name: RE3568
kinetic law: MODEL1310110051#

metaM acnam l
initial concentration: 1.0
is: HMDB00230
boundary condition: false
type: Species
name: N-acetylneuraminate
constant: false
is: CHEBI:35418
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaM sphgn c
name: sphinganine(1+)
has only substance units: false
type: Species
is: CHEBI:57817
constant: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial amount: NaN
initial concentration: 1.0
is: HMDB00269
boundary condition: false
is: SBO:0000247

metaR ALOX52
is: SBO:0000176
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.13.11.34
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
reactant: MODEL1310110051#
modifier: MODEL1310110051#
name: Arachidonate 5-lipoxygenase
is described by: ECO:0000269
reversible: false
fast: false
type: Reaction

metaM 5pmev x
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: (R)-5-phosphonatomevalonate(3-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
is: HMDB01343
has only substance units: false
is: CHEBI:58146

metaR ASNCYSNaEx
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185
product: MODEL1310110051#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
reversible: false
is described by: ECO:0000269

metaM pnto R e
name: (R)-Pantothenate
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:7916
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
has only substance units: false
is: HMDB00210

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR r2098
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR GLYt7 311 r
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000006
reversible: true
name: glycine reversible transport via sodium and chloride symport (3:1:1)
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110051#
is: SBO:0000185
fast: false

metaM itaccoa m
is: HMDB03377
name: itaconyl-CoA(5-)
type: Species
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57381
boundary condition: false

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
is: SBO:0000185

metaR r1877
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#

metaR GLCNACASE4ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110051#
type: Reaction
fast: false
modifier: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110051#

metaR DSREDUCr
product: MODEL1310110051#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
name: Desmosterol reductase
fast: false
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#

metaM ivcoa c
boundary condition: false
name: Isovaleryl-CoA
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01113
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
constant: false

metaR S3TASE3ly
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
type: Reaction
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR r0523
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000

metaR BTNt4i
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
fast: false
modifier: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
name: Biotin uptake (antiport)
reactant: MODEL1310110051#

metaM c101crn c
notes: FORMULA: C17H31NO4 CHARGE: 0
is: HMDB13205
initial concentration: 1.0
name: decenoyl carnitine
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaR FAOXTC182TC162m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaM q10h2 c
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
boundary condition: false
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
is: HMDB13111
initial concentration: 1.0
name: Ubiquinol-10
initial amount: NaN

metaR PRO Dtde
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
name: D-proline transport, extracellular
is described by: ECO:0000134
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaM ribflv c
constant: false
is: SBO:0000247
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial amount: NaN
is: HMDB00244
has only substance units: false
type: Species
is: CHEBI:3554
is: C00255
initial concentration: 1.0
name: Riboflavin
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_66291929_9301_42cd_b9e9_a9dfde10a599
type: Species
is encoded by: hsa:1544
is: P05177
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: CYP1A2
initial concentration: NaN

metaM hs deg19 l
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17180
constant: false
is: HMDB01352
boundary condition: false
name: heparan sulfate, degradation product 19

metaM 3octdectecoa m
has only substance units: false
is: SBO:0000247
name: 3,6,9,12-octadecatetraenoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaR LDH L
reversible: true
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
name: L-lactate dehydrogenase
is: SBO:0000176

metaR LNLNCGCPT2
product: MODEL1310110051#
is described by: ECO:0000269
reversible: false
name: carnitine transferase
modifier: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_ec3a6da8_f468_4958_a33f_a5aa4149605a
boundary condition: true
constant: false
has only substance units: false
type: Species
is: O43252
name: PAPSS1
is encoded by: hsa:9061
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR RE1901R
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
is: SBO:0000176
name: RE1901
reactant: MODEL1310110051#

metaM h2o r
is: CHEBI:15377
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB02111
initial amount: NaN
name: H2O
boundary condition: false
constant: false
type: Species
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR MTHFD2
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
name: methylenetetrahydrofolate dehydrogenase (NAD)
kinetic law: MODEL1310110051#
reversible: true
fast: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
modifier: MODEL1310110051#
product: MODEL1310110051#

metaR C3STKR2r
product: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110051#
name: C-3 sterol keto reductase (zymosterol)
reactant: MODEL1310110051#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ

metaR r2310
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110051#_6351ce53_f11f_4de9_b2ca_1b078e9cab31
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110051#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reactant: MODEL1310110051#

metaR CYTK5n
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110051#
name: cytidylate kinase (CMP),nuclear

metaR FAOXC180x
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110051#
is: SBO:0000176
fast: false

metaR TTDCAFATPc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_02b6b1de_79f1_4f54_a7e5_89decc12f856
type: Species
constant: false
is: P51841
name: GUCY2F
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2986
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR CMPSAS
fast: false
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.7.43
type: Reaction
is described by: ECO:0000304
product: MODEL1310110051#
is: SBO:0000176
reversible: false
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_143e3f67_66e0_4fe5_b3c9_38d957ec562d
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PKM2
is encoded by: hsa:5315
constant: false
boundary condition: true
is: P14618
type: Species

metaR PROSTGE1t
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
reversible: true
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110051#
is: SBO:0000185

metaM pristcoa x
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: CHEBI:51341
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: pristanoyl coa
boundary condition: false
initial amount: NaN

metaR LNLNCGCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is: SBO:0000176

metaM ksii core4 pre8 g
is: SBO:0000247
has only substance units: false
is: HMDB00175
initial amount: NaN
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 8
type: Species
is: CHEBI:58053
initial concentration: 1.0
is: C00130
notes: FORMULA: C83H134N7O61SX CHARGE: -2
constant: false

metaR 5ADTSTSTERONEte
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: 5 alpha dihydrotesterone transport
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110051#
type: Reaction
fast: false
kinetic law: MODEL1310110051#

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_261a4b0f_cab7_4f8c_bece_c504c8e30392
is encoded by: hsa:AI694761
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: _AI694761_1_c
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_b3d147ea_7bc4_4e7f_86c6_f361cba9df3d
type: Species
constant: false
is encoded by: hsa:4725
initial amount: NaN
has only substance units: false
name: NDUFS5
is: SBO:0000252
boundary condition: true
is: Q6IBA0
initial concentration: NaN

metaM ttdcrn m
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3413344
is: HMDB05066
initial concentration: 1.0
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
has only substance units: false
constant: false
name: tetradecanoyl carnitine

metaM acetone m
is: CHEBI:15347
type: Species
boundary condition: false
name: acetone
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a619ad1a_73c5_4167_b960_16299a00637b
type: Species
name: DPM2
boundary condition: true
is encoded by: hsa:8818
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaR LNLCCPT2
fast: false
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is: SBO:0000176
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110051#_54106595_e430_4446_9bfa_75eb9752b130
type: Species
is encoded by: hsa:AV717590
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AV717590_1_m
boundary condition: true

metaM ksi deg4 l
initial concentration: 1.0
name: keratan sulfate I, degradation product 4
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57737
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
type: Species
is: HMDB00868
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_c8c797f6_1cd2_47dc_8b0b_b9f147fe0a67
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
name: PANK1
initial concentration: NaN
is encoded by: hsa:53354
is: SBO:0000252

metaR C5DCe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaR FRDPtcr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
fast: false
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000134
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
kinetic law: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185

metaM ksi deg37 l
is: CHEBI:57455
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 37
notes: FORMULA: C62H104N4O46 CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01354
boundary condition: false
initial amount: NaN

metaR HDECAACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_7a8b0d93_e5f4_400d_ba66_37f0d91d6d7c
is: O14732
type: Species
constant: false
boundary condition: true
name: IMPA2
has only substance units: false
initial amount: NaN
is encoded by: hsa:3613
is: SBO:0000252
initial concentration: NaN

metaM undcoa m
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
type: Species
name: undecanoylcoa
is: SBO:0000247
is: HMDB13114
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_ca721bf1_758f_43e2_bafb_dce942d31384
initial amount: NaN
has only substance units: false
name: ABCD1
is encoded by: hsa:215
boundary condition: true
is: SBO:0000252
is: P33897
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_33271d35_727d_4bab_9b86_c595cbdf4d43
is: SBO:0000252
is encoded by: hsa:9963
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: SLC23A1

http://identifiers.org/biomodels.db/MODEL1310110051#_c26f8239_809d_4dfc_9728_f19b04cdd862
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: ACAD11
initial amount: NaN
is: Q709F0
is encoded by: hsa:84129
has only substance units: false
type: Species

metaM 10fthf m
has only substance units: false
is: CHEBI:57454
is: SBO:0000247
is: HMDB00972
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
type: Species
name: 10-formyltetrahydrofolate(2-)
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_d6acee58_47df_4d42_a1a1_ccb8f6ab5612
boundary condition: true
has only substance units: false
is: P08195
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6520
constant: false
initial concentration: NaN
type: Species
name: SLC3A2

metaR r2316
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110051#
product: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_580bb5d6_b51d_41f8_8bd7_16ee4885ba13
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:84343
type: Species
initial amount: NaN
name: HPS3
initial concentration: NaN
is: Q969F9

metaM tethex3coa x
constant: false
name: tetracosahexaenoyl coenzyme A
is: HMDB06243
initial concentration: 1.0
is: C16168
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205478
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
type: Species

metaR r0381
is: SBO:0000176
type: Reaction
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
product: MODEL1310110051#
reversible: true

metaR H2O2tp
name: hydrogen peroxide peroxisomal transport via diffusion
is: SBO:0000185
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reversible: true

metaR r0527
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: true
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42

metaR GALtly
type: Reaction
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000185
product: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: galactose efflux from lysosome
is described by: ECO:0000000

metaM ppi x
type: Species
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Diphosphate
is: HMDB00250
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:33019

metaR UDPGLCAter
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
kinetic law: MODEL1310110051#
reversible: true
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD

metaR RE3003M
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3003
product: MODEL1310110051#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
fast: false
reactant: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR r2315
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#

metaR 7DHCHSTEROLtr
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000185
name: cholesterol precursor intracellular transport
is described by: ECO:0000000
reversible: true

metaM dolmanp L c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human liver homolog
has only substance units: false
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809

http://identifiers.org/biomodels.db/MODEL1310110051#_68b9870d_3966_47ae_bc5c_100534afd5b8
name: NME3
is encoded by: hsa:4832
constant: false
is: SBO:0000252
is: Q13232
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaM h2o n
has only substance units: false
initial concentration: 1.0
is: CHEBI:15377
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
constant: false
name: water
is: HMDB02111
is: SBO:0000247
boundary condition: false

metaR RE2660N
type: Reaction
reversible: true
fast: false
name: RE2660
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_78177990_f68a_4825_81ca_62e1492d3685
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:7378
is: SBO:0000252
boundary condition: true
has only substance units: false
name: UPP1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_fe5288b7_c0cc_4af6_8a22_6a35de04c3f7
is: P15531
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4830
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NME1
type: Species

metaM hs deg10 l
initial concentration: 1.0
is: CHEBI:15748
has only substance units: false
name: heparan sulfate, degradation product 10
boundary condition: false
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
type: Species
is: HMDB00127
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_c5dcd2dc_a758_4b71_a45b_f78f1bd1aa26
is: Q9BXI2
name: SLC25A2
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:83884

metaR MTHFD2m
is described by: ECO:0000254
reactant: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176

metaR r2314
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110051#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_aedaf9b1_a4cb_4185_8e4b_16ac5cdede65
constant: false
type: Species
is encoded by: hsa:AU149534
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AU149534_1_m
initial amount: NaN
initial concentration: NaN

metaR RE0453N
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
name: RE0453
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
modifier: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaM c101crn e
is: SBO:0000247
notes: FORMULA: C17H31NO4 CHARGE: 0
has only substance units: false
type: Species
boundary condition: false
is: HMDB13205
initial amount: NaN
initial concentration: 1.0
name: decenoyl carnitine
constant: false

metaM pnto R c
name: (R)-Pantothenate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
has only substance units: false
type: Species
is: HMDB00210
initial amount: NaN
constant: false

metaR r0383
name: pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) EC:1.2.4.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.1 Confidence Level: 0 AUTHORS: PMID:18032470,PMID:2323578,PMID:2748588 NOTES:
reactant: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110051#

metaR FAOXC221C201x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR r1871
fast: false
modifier: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_2e27a5df_9784_4f01_9fe7_71e177505e37
is: Q8IWX5
boundary condition: true
has only substance units: false
name: SGPP2
is encoded by: hsa:130367
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR DHFR
is described by: ECO:0000254
name: dihydrofolate reductase
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:

metaR r2313
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR DOLMANP Uter
is described by: ECO:0000000
name: dolichol-phosphate mannose flippase (uterus)
kinetic law: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_b96b091a_519e_4ba6_99cd_0d2bf1d6ad9d
is: P49441
has only substance units: false
is encoded by: hsa:3628
name: INPP1
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_2ad37d61_0fb8_4287_a210_4a2f0aeb2a48
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q16635
name: TAZ
is encoded by: hsa:6901
has only substance units: false
initial concentration: NaN
constant: false

metaM adp x
is: CHEBI:456216
name: ADP(3-)
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
has only substance units: false
is: HMDB01341
constant: false

metaM adn e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00050
name: Adenosine
is: CHEBI:16335
is: C00212
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species

metaR CRNt
is described by: ECO:0000269
name: L-carnitine reversible transport
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reversible: true
type: Reaction
modifier: MODEL1310110051#
is: SBO:0000185

metaM dgtp e
name: dGTP
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:16497
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
boundary condition: false

metaM camp c
constant: false
name: 3',5'-cyclic AMP(1-)
is: SBO:0000247
is: HMDB00058
is: CHEBI:58165
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
initial amount: NaN
type: Species
boundary condition: false

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR A MANASEly
name: alpha-mannosidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.24
type: Reaction
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
fast: false
reversible: false
modifier: MODEL1310110051#

metaM dd2coa m
constant: false
has only substance units: false
is: CHEBI:57330
initial amount: NaN
boundary condition: false
type: Species
name: trans-dodec-2-enoyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221

http://identifiers.org/biomodels.db/MODEL1310110051#_9a3e6cef_b3e6_4e32_97bd_5bd928536d2f
is: SBO:0000252
is encoded by: hsa:AI440329
name: _AI440329_1_r
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM ksi deg1 e
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: CHEBI:17268
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00211
initial amount: NaN
name: keratan sulfate I, degradation product 1
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_7243e12f_19c3_4cd2_be22_4914a9e6acf2
name: B3GNT2
is encoded by: hsa:10678
is: Q9NY97
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaM gluside hs r
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaR XYLUR
fast: false
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
name: xylulose reductase
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.10
product: MODEL1310110051#
is described by: ECO:0000269

metaM core4 g
name: Core 4
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0
type: Species

metaR r2319
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110051#
reversible: true
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110051#
fast: false
type: Reaction

metaR TAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: triacylglycerol transport

metaM acetone c
type: Species
is: HMDB01659
initial amount: NaN
is: CHEBI:15347
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: acetone
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaR FAOXC2242046x
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110051#
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM dttp c
is: C00459
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
name: dTTP
constant: false
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
has only substance units: false
is: CHEBI:37568

metaR HSD3A2r
product: MODEL1310110051#
reversible: true
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_e656e972_1204_4fdf_b8c1_67178dae3423
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:10396
type: Species
is: SBO:0000252
name: ATP8A1
is: Q9Y2Q0
initial amount: NaN
has only substance units: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR CLPNDCOAtx
is: SBO:0000185
reactant: MODEL1310110051#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110051#
type: Reaction
name: fatty acid intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110051#

metaR NACHEX16ly
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ef1ed10c_3d3e_4a68_9580_98198d2bd42b
boundary condition: true
type: Species
is: Q14117
constant: false
has only substance units: false
is encoded by: hsa:1807
initial amount: NaN
name: DPYS
is: SBO:0000252
initial concentration: NaN

metaR DESAT18 3
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

metaM adn c
type: Species
name: Adenosine
initial concentration: 1.0
is: SBO:0000247
is: HMDB00050
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
is: CHEBI:16335
is: C00212
boundary condition: false
constant: false
initial amount: NaN

metaM ksi pre12 g
boundary condition: false
type: Species
is: C00130
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 12
has only substance units: false
initial concentration: 1.0
is: HMDB00175
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: CHEBI:58053
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_7d0e0ef2_3c73_4a42_8885_7b8e8de44fe4
has only substance units: false
initial amount: NaN
is encoded by: hsa:2181
type: Species
name: ACSL3
is: SBO:0000252
is: B3KMA6
constant: false
boundary condition: true
initial concentration: NaN

metaR r0639
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110051#

metaR r2318
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110051#
is: SBO:0000185

metaM 1p3h5c m
is: CHEBI:6151
type: Species
initial amount: NaN
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: HMDB01369
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281

metaR LDH D
is: SBO:0000176
kinetic law: MODEL1310110051#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
name: D-lactate dehydrogenase
reversible: true
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#

metaM prostge2 c
name: prostaglandin E2(1-)
is: CHEBI:606564
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01220
is: SBO:0000247

metaM docoscoa x
is: HMDB12930
type: Species
name: docosanoylcoa
has only substance units: false
is: SBO:0000247
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR DESAT18 4
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
is described by: ECO:0000000
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110051#

metaM ksii core2 pre1 g
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
type: Species
constant: false
name: keratan sulfate II biosynthesis, precursor 1
notes: FORMULA: C33H53N3O23X CHARGE: -1
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_22bbfcfc_3b21_4812_8c12_f87b0630bf84
is: O75874
is encoded by: hsa:3417
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: IDH1
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_731581de_e1b3_41f2_ace9_c4afa2c52305
type: Species
boundary condition: true
is: SBO:0000297
initial amount: NaN
has part: P13804
has only substance units: false
name: ETFA:ETFB
constant: false
is encoded by: hsa:2109
is encoded by: hsa:2108
initial concentration: NaN

metaM ppi r
is: CHEBI:33019
name: Diphosphate
initial amount: NaN
is: C00013
is: HMDB00250
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaM mmcoa S m
constant: false
has only substance units: false
is: HMDB02310
type: Species
initial concentration: 1.0
name: (S)-methylmalonyl-CoA(5-)
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57327

metaR r0638
kinetic law: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
reactant: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110051#

metaM acetone e
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial amount: NaN
has only substance units: false
is: CHEBI:15347
type: Species
is: HMDB01659
is: SBO:0000247
constant: false
name: acetone
initial concentration: 1.0
boundary condition: false

metaR r2317
fast: false
reversible: true
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#

metaR RE2069C
reversible: true
is: SBO:0000176
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
name: RE2069
is described by: ECO:0000000

metaR GUAt
name: Guanine transport
kinetic law: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
fast: false
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_1177641e_d062_4d01_abe2_4c853b0ddb9d
initial amount: NaN
constant: false
is: B4DFS7
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:2530
name: FUT8
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_331820a5_9111_487d_a2e8_87e286d6464c
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:84569
initial concentration: NaN
name: LYZL1
initial amount: NaN
is: Q6UWQ5
constant: false
is: SBO:0000252

metaR S6TASE8ly
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: N-acetylgalactosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110051#

metaR 5MTHFt
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
fast: false
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reversible: true
modifier: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
product: MODEL1310110051#
is: SBO:0000185

metaM dttp e
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: dTTP(4-)
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_36ba6272_1dfe_4501_8991_8ed323242f95
boundary condition: true
is: SBO:0000297
initial concentration: NaN
name: VNN3:VNN2:VNN1
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:55350
type: Species

metaR FAOXC240200x
is described by: ECO:0000000
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:0 -> c20:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR FAOXC16080x
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR XYLTt
product: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000185
name: Xylitol transport via passive diffusion
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#

metaR r1143
fast: false
modifier: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:

metaR RE1532M
name: RE1532
kinetic law: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110051#

metaM prostge2 e
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01220
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
is: CHEBI:606564
name: prostaglandin E2(1-)
constant: false

metaR TRDRm
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.9
product: MODEL1310110051#
name: thioredoxin reductase (NADPH)
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
is described by: ECO:0000269

metaM h2o x
is: HMDB02111
name: H2O
initial amount: NaN
is: CHEBI:15377
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
type: Species
boundary condition: false
has only substance units: false
is: C00001

metaR GLUDym
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110051#
type: Reaction
reversible: true

metaR r2516
product: MODEL1310110051#
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110051#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r0633
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110051#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.3
type: Reaction

metaM coa x
is: CHEBI:57287
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
boundary condition: false
is: C00010

http://identifiers.org/biomodels.db/MODEL1310110051#_89feec49_6a9a_4306_8f21_59f89aeecf21
type: Species
is encoded by: hsa:92483
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: LDHAL6B
is: Q9BYZ2
has only substance units: false

metaR DESAT18 6
fast: false
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
is: SBO:0000176

metaR BTNDe
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000269
name: biotinidase (biotin), extracellular
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
reversible: false
type: Reaction
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_45047549_5a84_403c_aa87_7967f282383f
is: P56556
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFA6
is encoded by: hsa:4700
constant: false
initial amount: NaN
is: SBO:0000252

metaR r1144
is: SBO:0000185
fast: false
modifier: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_0ac4b634_ea9a_43af_89e1_5502b1147ea1
has only substance units: false
initial amount: NaN
type: Species
name: NDUFB6
constant: false
is encoded by: hsa:4712
initial concentration: NaN
is: SBO:0000252
is: O95139
boundary condition: true

metaR TRDR
kinetic law: MODEL1310110051#
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
name: thioredoxin reductase (NADPH)
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110051#

metaR LEUyLAThtc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM 7dhchsterol c
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: cholesta-5,7-dien-3beta-ol
boundary condition: false
is: CHEBI:17759
is: SBO:0000247
has only substance units: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_8d27d67c_9a55_4c13_8977_8e13db1d2e71
is: SBO:0000252
boundary condition: true
is: Q16720
initial concentration: NaN
initial amount: NaN
name: ATP2B3
type: Species
constant: false
is encoded by: hsa:492
has only substance units: false

metaM glyc R m
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate
is: CHEBI:16659
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00139
constant: false

metaR GLUt7l
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction
name: Glutamate transport, lysosomal
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR CGMPt
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10257.1) or (10057.2) or (10057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11447229,PMID:12637526,PMID:12835412,PMID:14507663,PMID:15631998 NOTES:IT
name: cGMP transport (ATP-dependent)
product: MODEL1310110051#
is: SBO:0000185
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#

metaM od2coa m
name: trans-Octadec-2-enoyl-CoA
is: SBO:0000247
is: CHEBI:50570
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB06529
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
constant: false

metaM retinal cis 13 r
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB06220
is: CHEBI:45487
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
name: 13-cis-retinal

metaR RE2660C
kinetic law: MODEL1310110051#
name: RE2660
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_c2c0cd11_477b_4f65_a17c_fda3febfab61
initial concentration: NaN
is: Q9Y2P5
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: SLC27A5
is encoded by: hsa:10998
initial amount: NaN
constant: false

metaR FAOXC164GC163m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR H2Ot
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
type: Reaction
is: SBO:0000185
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
name: H2O transport via diffusion
kinetic law: MODEL1310110051#

metaM 10fthf c
is: C00234
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
initial concentration: 1.0
is: HMDB00972

http://identifiers.org/biomodels.db/MODEL1310110051#_5bbc5dae_0095_4b61_9d2b_bafa83bba6ef
is: B3KT19
has only substance units: false
is: SBO:0000252
constant: false
name: PIK3R1
is encoded by: hsa:5295
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaR AKR1C42
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110051#
reversible: false
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaM dgtp c
boundary condition: false
is: HMDB01440
constant: false
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00286
has only substance units: false
name: dGTP

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_b94a0442_5720_4e7a_adb4_7c174aa4c327
boundary condition: true
is: Q15758
type: Species
is encoded by: hsa:6510
is: SBO:0000252
name: SLC1A5
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM tststerone r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00234
is: CHEBI:17347
type: Species
name: testosterone
initial amount: NaN
constant: false
has only substance units: false

metaM nrpphr e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial concentration: 1.0
is: CHEBI:33569
name: Norepinephrine
initial amount: NaN
is: HMDB00216
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c8618760_87ba_44a2_8267_3c407589ef54
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:55343
is: B3KQH0
type: Species
is: SBO:0000252
has only substance units: false
name: SLC35C1
initial amount: NaN

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

metaM ksi deg12 l
name: keratan sulfate I, degradation product 12
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9

metaM dmnoncrn c
has only substance units: false
name: 4,8-dimethylnonanoyl carnitine
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H37NO4 CHARGE: 0
is: HMDB06202
is: SBO:0000247

metaR r0634
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
fast: false
modifier: MODEL1310110051#
reversible: true
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110051#_98db1f69_3850_4bc5_8b85_b552a8d9886a
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79611
name: ACSS3
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9H6R3
constant: false
boundary condition: true

metaM ppi n
name: diphosphate(3-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
initial concentration: 1.0
type: Species
is: CHEBI:33019
initial amount: NaN
boundary condition: false
constant: false

metaM Ser Thr l
initial concentration: 1.0
has only substance units: false
type: Species
name: protein-linked serine or threonine residue (O-glycosylation site)
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: HMDB00224
boundary condition: false
constant: false
is: CHEBI:58190
is: SBO:0000247

metaR MGSA
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
fast: false
name: methylglyoxal synthase
reactant: MODEL1310110051#
reversible: false
is: SBO:0000176

metaM acnam n
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:35418
initial amount: NaN
type: Species
is: SBO:0000247
name: N-acetylneuraminate
is: HMDB00230
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaR FAS100COA
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
is described by: ECO:0000269
name: fatty acyl-CoA synthase (n-C10:0CoA)

metaR DHCR72r
reversible: false
modifier: MODEL1310110051#
name: 7-dehydrocholesterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.21
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is: SBO:0000176
kinetic law: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
fast: false

metaM ivcoa m
is: HMDB01113
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
type: Species
initial amount: NaN
name: Isovaleryl-CoA
has only substance units: false
is: CHEBI:57345
is: SBO:0000247
constant: false
boundary condition: false

metaM 3octdectecoa x
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
initial amount: NaN
name: 3,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0e1022ad_bf42_49e5_8293_9343eeb93794
has only substance units: false
name: INPP5J
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q15735
is encoded by: hsa:27124

metaM adp n
initial amount: NaN
is: HMDB01341
has only substance units: false
type: Species
initial concentration: 1.0
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
boundary condition: false
is: CHEBI:456216
is: SBO:0000247

metaM h2o e
boundary condition: false
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02111
type: Species
is: C00001
name: H2O
initial concentration: 1.0
is: SBO:0000247

metaR DHCR71r
modifier: MODEL1310110051#
reversible: false
is described by: ECO:0000134
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
name: 7-dehydrocholesterol reductase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.1.21

metaR LYStm
name: Lysine mitochondrial transport via ornithine carrier
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
type: Reaction
reversible: true

metaR RE2985X
fast: false
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.99.3
kinetic law: MODEL1310110051#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110051#
name: RE2985
is described by: ECO:0000000

metaR S6TASE1ly
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110051#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false

metaM ksii core4 deg1 l
has only substance units: false
is: CHEBI:57737
is: HMDB00868
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 1
type: Species
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
constant: false

metaM s2l2n2m2masn e
type: Species
boundary condition: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: CHEBI:3554
constant: false
is: SBO:0000247
is: HMDB00244
name: de-Fuc form of PA6
has only substance units: false
initial concentration: 1.0
is: C00255
initial amount: NaN

metaR ABTD
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: L-arabinitol 4-dehydrogenase
product: MODEL1310110051#

metaR r1148
reversible: true
product: MODEL1310110051#
is: SBO:0000185
name: Active transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110051#

metaM m6masnC g
boundary condition: false
constant: false
is: HMDB00573
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: CHEBI:30825
is: SBO:0000247
type: Species
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110051#_6dea4d49_04dd_4c4d_b1a9_08c308832816
boundary condition: true
is: Q8TBG4
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:64850
name: AGXT2L1
has only substance units: false
constant: false

metaR TETTET6COAtx
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_15579acc_3bf5_4ddd_834e_31cce76f9849
name: SLC25A15
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: Q9Y619
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10166

http://identifiers.org/biomodels.db/MODEL1310110051#_e7c54fb5_946e_4ffe_89ee_351e48143020
boundary condition: true
constant: false
initial amount: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q5VYT2
is encoded by: hsa:4712
has only substance units: false
is encoded by: hsa:4731
initial concentration: NaN
is: SBO:0000297
type: Species

metaR It
type: Reaction
name: Iodide uniport
reversible: true
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185

metaM nrpphr c
is: CHEBI:33569
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
constant: false
is: HMDB00216

metaR r2508
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: Utilized transport
is: SBO:0000185
type: Reaction

metaM ppi m
boundary condition: false
constant: false
is: HMDB00250
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
type: Species
initial amount: NaN
is: CHEBI:33019

metaR r0641
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is: SBO:0000176

metaR FAOXC16080m
reversible: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR C60CPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR r1147
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110051#
reversible: true
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185

metaM 3mox4hoxm c
has only substance units: false
is: CHEBI:27622
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
boundary condition: false
constant: false
is: HMDB00291
initial concentration: 1.0
is: SBO:0000247
name: 3-Methoxy-4-hydroxymandelate
initial amount: NaN
type: Species

metaM ksi deg1 l
name: keratan sulfate I, degradation product 1
is: CHEBI:18287
boundary condition: false
initial concentration: 1.0
is: HMDB00174
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_31287781_b8d9_4bc5_a34a_62195bb9adca
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is: Q68CJ7
name: UROC1
is encoded by: hsa:131669
initial amount: NaN

metaM h2o c
is: HMDB02111
is: C00001
is: CHEBI:3303
boundary condition: false
initial amount: NaN
has only substance units: false
name: H2O
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_db6537d4_c4f2_428e_9eca_624d938aff24
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AA977580
is: SBO:0000252
name: _AA977580_1_c
initial amount: NaN
type: Species
boundary condition: true

metaR AHC
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
name: adenosylhomocysteinase
is version of: http://identifiers.org/ec-code/3.3.1.1
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
type: Reaction
is described by: ECO:0000269

metaM glyc R c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00139
name: D-glycerate
is: CHEBI:16659
type: Species
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: SBO:0000247
constant: false

metaR FAOXC141C121x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_41db2e46_4bcc_46ee_bd29_cfc81544bf1e
is: Q86V21
is encoded by: hsa:65985
name: AACS
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR MAN6PI
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/5.3.1.8
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000304
name: mannose-6-phosphate isomerase
product: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_dff72bec_c440_4801_90ae_5c1d20beecd3
boundary condition: true
type: Species
is encoded by: hsa:55967
name: NDUFA12
is: SBO:0000252
is: F8VQS7
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaR r0642
reversible: true
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_991353d2_eceb_4920_895e_fb275a0510b3
is: Q9Y233
is encoded by: hsa:10846
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: PDE10A
type: Species
initial concentration: NaN
initial amount: NaN

metaM gluside hs l
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
has only substance units: false

metaM adp m
constant: false
initial concentration: 1.0
name: ADP
is: C00008
is: CHEBI:456216
is: HMDB01341
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN

metaR EX c51crn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM 7dhchsterol r
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17759
type: Species
is: SBO:0000247
is: HMDB00032
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN

metaM clpnd c
boundary condition: false
has only substance units: false
type: Species
constant: false
is: HMDB06528
is: CHEBI:53488
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
name: clupanodonic acid

metaR DDECE1CRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM dd2coa x
initial amount: NaN
type: Species
name: trans-Dodec-2-enoyl-CoA
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB03712

metaR r1757
kinetic law: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_7618992c_deaa_442f_8093_74db6ad78110
constant: false
boundary condition: true
is encoded by: hsa:R14373
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _R14373_1_x
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_f5926da7_60c6_43c4_b7ad_8deff71a0f69
is: SBO:0000252
name: ENPP1
is: P22413
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5167

metaR FE2t
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
kinetic law: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110051#
name: iron (II) transport
type: Reaction

metaM adp r
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
is: CHEBI:456216
name: ADP(3-)
has only substance units: false

metaR DCSPTN1CPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000269
product: MODEL1310110051#
reversible: false
is: SBO:0000176
fast: false

metaM dolp L r
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57683
type: Species
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR XOL7AONEtr
product: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
reversible: true
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaR FATP6t
is described by: ECO:0000269
name: fatty acid electroneutral transport
is: SBO:0000185
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110051#
reversible: true
fast: false
type: Reaction

metaM octdececoa c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
name: octadecenoylcoa
is: HMDB06351
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_72eae7a2_932b_483b_8a6b_258c74e9a1ed
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: Q99685
name: MGLL
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11343

metaR r0494
is: SBO:0000176
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
kinetic law: MODEL1310110051#

metaR AG13T1g
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

metaR C16DCe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaM ksi deg7 l
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
name: keratan sulfate I, degradation product 7
is: CHEBI:57455
boundary condition: false
is: HMDB01354
initial concentration: 1.0
has only substance units: false

metaR LEUKTRA4t
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000269
product: MODEL1310110051#
name: leukotriene A4 transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaM mev R c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: HMDB00227
name: (R)-mevalonate
constant: false
is: CHEBI:36464
boundary condition: false
type: Species
has only substance units: false

metaM ascb L e
name: L-ascorbate
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00044
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
has only substance units: false
is: CHEBI:38290
is: SBO:0000247

metaM clpnd e
is: CHEBI:53488
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: HMDB06528
name: clupanodonic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM Ser Thr g
constant: false
initial amount: NaN
boundary condition: false
name: protein-linked serine or threonine residue (O-glycosylation site)
notes: FORMULA: XH CHARGE: 0
type: Species
has only substance units: false
is: CHEBI:58336
initial concentration: 1.0
is: SBO:0000247
is: HMDB00645

metaR LTA4H
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.3.2.6
name: Leukotriene A-4 hydrolase

metaR GLYOp
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
product: MODEL1310110051#
name: glycine oxidase, perixosomal
is described by: ECO:0000000

metaM dmnoncrn x
notes: FORMULA: C18H37NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
name: 4,8-dimethylnonanoyl carnitine
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06202
constant: false
is: SBO:0000247

metaR G14T4g
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction

metaR r0940
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110051#
name: Free diffusion
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaM mi1345p c
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57895
is: HMDB01059
type: Species
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_afcee453_590d_4d66_b6bf_c19f82d25b25
is: SBO:0000252
is encoded by: hsa:8526
initial concentration: NaN
is: A1L4Q0
name: DGKE
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_e4d0b3af_29e5_4915_ba3a_8685f0672e49
is: O43505
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:11041
name: B3GNT1
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaR FAOXC22C20x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22-->C20)x
type: Reaction

metaM c51crn c
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: tiglyl carnitine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H21NO4 CHARGE: 0
initial amount: NaN
is: HMDB02366

metaM 2mb2coa c
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 2-methylcrotonoyl-CoA(4-)
initial concentration: 1.0
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_9e86e4af_7981_43d0_9568_f0fe8e7e24b9
is encoded by: hsa:2589
constant: false
is: SBO:0000252
initial amount: NaN
is: Q10472
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: GALNT1

metaM 3mox4hpac m
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
is: CHEBI:28111
is: HMDB05175
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2020a325_234b_48f5_9ee4_fc29b2424e70
is encoded by: hsa:9498
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: SLC4A8
initial concentration: NaN
is: E7EML0

metaR r0941
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Free diffusion
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_d33f6fe0_54c3_4bae_bbbe_19ef7f936d3f
is encoded by: hsa:6555
is: Q12908
initial amount: NaN
is: SBO:0000252
type: Species
name: SLC10A2
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_8f72418f_960d_47f4_9d0e_e9076ef448ab
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
name: CHKA
initial amount: NaN
is encoded by: hsa:1119
initial concentration: NaN

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR LAPCOAl
reversible: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
type: Reaction
fast: false
name: lysosomal acid phosphorylase (CoA)
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
is version of: http://identifiers.org/ec-code/3.1.3.2

metaR PSDm hs
name: Phosphatidylserine decarboxylase
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.1.1.65
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000176

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM pristcoa c
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:51341
initial concentration: 1.0
boundary condition: false
name: pristanoyl coa
initial amount: NaN
constant: false

metaR OCTDECCPT1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR MELATNOX
modifier: MODEL1310110051#
fast: false
reversible: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.14.13.48
name: Melatonin:NADP oxidoreductase
is version of: http://identifiers.org/ec-code/1.14.14.1
is: SBO:0000176
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_45d92b63_a1ed_4882_a191_e50e939a2975
initial amount: NaN
name: CAD
constant: false
has only substance units: false
is: P27708
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:790
initial concentration: NaN

metaR S6TASE12ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110051#

metaR r0942
fast: false
is: SBO:0000185
reversible: true
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
product: MODEL1310110051#

metaR DCSPTN1CPT2
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110051#

metaR ETOHtx
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: ethanol reversible peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
product: MODEL1310110051#
fast: false

metaR ACCOAtn
product: MODEL1310110051#
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_19fe3440_9145_40fb_94d6_41158146451c
initial concentration: NaN
has only substance units: false
name: PIGX
constant: false
is encoded by: hsa:54965
is: Q8TBF5
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM dolmanp L r
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809

metaM ha deg1 l
is: CHEBI:16336
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
name: hyaluronan degradation product 1
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1

metaR r0497
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
type: Reaction
reversible: true
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_6d3f6f16_c376_43e8_9869_82e04fa7e9b8
is: P48751
constant: false
name: SLC4A3
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6508
is: SBO:0000252

metaR OCTDECCPT2
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM c51crn e
constant: false
boundary condition: false
initial concentration: 1.0
name: tiglyl carnitine
initial amount: NaN
notes: FORMULA: C12H21NO4 CHARGE: 0
has only substance units: false
is: HMDB02366
is: SBO:0000247
type: Species

metaM 34hpp c
is: HMDB00707
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM 3hddcoa m
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0
is: HMDB11123
type: Species
is: C05279
constant: false
initial amount: NaN
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
has only substance units: false

metaM dmnoncrn m
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 4,8 dimethylnonanoyl carnitine
is: HMDB06202
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_cc6feadd_bd64_46a9_a355_b11556513924
name: IVD
initial amount: NaN
is: B3KVI7
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:3712
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_0ebb4bc9_455c_482e_9c18_6307ec00e788
has only substance units: false
is: Q99624
is encoded by: hsa:10991
boundary condition: true
initial concentration: NaN
name: SLC38A3
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaM acnam c
is: CHEBI:35418
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false
is: HMDB00230
type: Species
name: N-acetylneuraminate
constant: false
is: SBO:0000247

metaM q10h2 m
boundary condition: false
constant: false
type: Species
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
initial concentration: 1.0
name: Ubiquinol-10

metaM tststerone c
boundary condition: false
constant: false
is: HMDB00234
name: testosterone
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
is: CHEBI:17347
initial concentration: 1.0

metaR r0385
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110051#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

metaM cs b deg2 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
constant: false
boundary condition: false
is: HMDB01354
is: SBO:0000247
type: Species
notes: FORMULA: C37H54NO41S3 CHARGE: -5
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57455
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a9ed8b39_8345_47a6_831f_dfeea3a0cc1b
boundary condition: true
has only substance units: false
name: _2544_1_c
is: SBO:0000252
constant: false
is encoded by: hsa:2544
initial concentration: NaN
type: Species
initial amount: NaN

metaR FACOAL150
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
name: fatty-acid--CoA ligase
type: Reaction
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR

metaM h2o m
type: Species
is: SBO:0000247
is: HMDB02111
is: CHEBI:15377
boundary condition: false
initial concentration: 1.0
name: H2O
is: C00001
has only substance units: false
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false

metaR TETHEX3COAtx
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_07bc6c98_ca16_4186_8793_3fae3c829fb9
is encoded by: hsa:7841
constant: false
boundary condition: true
is: SBO:0000252
name: MOGS
has only substance units: false
type: Species
is: F5H6D0
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_b4ca3824_5750_4c2b_ac83_8bc73800fd8c
is: SBO:0000252
initial concentration: NaN
is: Q9UFY1
type: Species
constant: false
is encoded by: hsa:5335
name: PLCG1
boundary condition: true
initial amount: NaN
has only substance units: false

metaR GALASE6ly
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
name: beta-galactosidase, lysosomal
is: SBO:0000176

metaM gluside hs c
constant: false
has only substance units: false
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:18368

metaR DHEAtr
product: MODEL1310110051#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
name: Dehydroepiandrosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:

metaR r0944
fast: false
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
name: Active transport
product: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:

metaM ppi e
type: Species
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
initial concentration: 1.0
is: C00013
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:33019
is: HMDB00250
boundary condition: false

metaR PGDI
is described by: ECO:0000269
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: true
name: Prostaglandin-H2 D-isomerase [Precursor]
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.3.99.2
product: MODEL1310110051#

metaM b2coa m
is: SBO:0000247
is: HMDB02009
constant: false
type: Species
is: CHEBI:57332
name: crotonoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
boundary condition: false
initial amount: NaN
has only substance units: false

metaM m5mpdol L r
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37634
constant: false

metaM h2o l
is: CHEBI:15377
name: water
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111

metaR FATP8t
type: Reaction
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110051#
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.7
fast: false
is: SBO:0000185
modifier: MODEL1310110051#
reversible: true
is described by: ECO:0000269
product: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_2305f614_fc6e_46ee_9c28_308b686b31a4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9H490
initial amount: NaN
name: PIGU
has only substance units: false
type: Species
constant: false
is encoded by: hsa:128869

metaR C16DCc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_7c24aa20_8e97_4197_8576_808644ddf5af
is encoded by: hsa:10246
is: SBO:0000252
is: O00624
has only substance units: false
name: SLC17A2
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_682200ed_b773_4a11_bcf5_6a5606ac8d4b
is: SBO:0000252
is encoded by: hsa:6569
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: Q7Z725
has only substance units: false
name: SLC34A1

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_3b03cc29_32d0_49b2_b42f_34675e8501aa
name: _AI935189_1_m
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AI935189
initial amount: NaN
boundary condition: true
has only substance units: false

metaM 34hpp e
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
has only substance units: false
is: SBO:0000247
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
initial concentration: 1.0
boundary condition: false
is: HMDB00707

metaR RE1897C
name: RE1897
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#

metaR TYMSFt
fast: false
name: Tyramine O-sulfate transport (diffusion)
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is: SBO:0000185

metaM ksii core2 deg4 l
type: Species
notes: FORMULA: C58H95N5O43SX CHARGE: -1
constant: false
has only substance units: false
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 4
is: CHEBI:57455
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01354

metaR DLNLCGCRNt
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
name: transport into the mitochondria (carnitine)

metaM od2coa c
is: C16218
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
boundary condition: false
is: CHEBI:50570
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB06529
name: trans-Octadec-2-enoyl-CoA

metaM udpg r
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species
is: HMDB00286
is: CHEBI:58367

metaR C204CPT1
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reversible: false
type: Reaction
name: carnitine C20:4 transferase
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1374.1) or (1375.4) or (1375.1) or (1375.3) or (1375.2) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110051#_894704bf_ee7a_4f9c_ae35_235e6c66770a
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q16831
is encoded by: hsa:7378
name: UPP1
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_67027549_9805_4473_8b01_563109541482
is: Q6LEN5
initial concentration: NaN
name: CHAT
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:1103
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_ce511086_98f1_47a8_9934_cf0b1f37fc3a
boundary condition: true
initial amount: NaN
name: PPA1
is: SBO:0000252
type: Species
is encoded by: hsa:5464
constant: false
is: Q15181
has only substance units: false
initial concentration: NaN

metaR S6T13g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_ecfb81f3_7926_4390_a22e_e951224f7514
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q06830
is encoded by: hsa:5052
initial concentration: NaN
constant: false
is: SBO:0000252
name: PRDX1

metaM biliverd c
name: biliverdin(2-)
initial amount: NaN
type: Species
is: HMDB01008
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57991
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_24860ccd_d3ef_4100_843a_8706a65c7571
has only substance units: false
constant: false
is: P22392
type: Species
is encoded by: hsa:4831
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NME2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_778584fd_c9fb_48a4_addd_55792051a909
is encoded by: hsa:56922
type: Species
is: Q96RQ3
name: MCCC1
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM ppi c
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:0
is: C00013
is: HMDB00250
type: Species
notes: FORMULA: HO7P2 CHARGE: -3
is: SBO:0000247
name: Diphosphate

metaR GAPD
name: glyceraldehyde-3-phosphate dehydrogenase
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.12
reversible: true

metaM ascb L c
initial concentration: 1.0
name: L-ascorbate
constant: false
has only substance units: false
is: CHEBI:38290
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_111ecb1c_7833_46af_8c6f_dfb0855c7692
has only substance units: false
is: Q96AS2
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:427
initial amount: NaN
is: SBO:0000252
name: ASAH1

metaM pail345p hs c
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial amount: NaN
is: CHEBI:57836
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species

metaR r0946
is: SBO:0000185
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110051#

metaR C204CPT2
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110051#
name: arachidonic acid transport into the mitochondria
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
reactant: MODEL1310110051#

metaR GLCAASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_21897a42_d477_44dd_9c10_75c431f359e3
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:6185
is encoded by: hsa:1603
boundary condition: true
has part: P04844
constant: false
is encoded by: hsa:1650
is encoded by: hsa:6184
type: Species
has only substance units: false
has part: Q53G02
initial amount: NaN
has part: P39656
name: DAD1:DDOST:RPN1:RPN2
has part: P04843

metaR r0531
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_72b0c925_3c41_4108_b5bf_d5c0fc425db0
is encoded by: hsa:34
is: P11310
has only substance units: false
name: ACADM
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_fc13d5b9_900a_47d0_9444_5960fe1f8a8a
initial concentration: NaN
name: PIK3R5
type: Species
is encoded by: hsa:23533
boundary condition: true
is: Q8WYR1
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaR CYTK6n
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,CTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110051#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_b63d1a5e_309d_4688_8f6d_e1a4797b2e42
constant: false
boundary condition: true
has only substance units: false
is: Q53TV9
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6120
name: RPE
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_391c90cf_274e_47bb_ada7_3c1d07a5fe51
is: SBO:0000252
name: SLC26A3
type: Species
is: P40879
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1811
boundary condition: true
constant: false
has only substance units: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR UDPGLCter
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110051#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport

metaR SPODMm
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is described by: ECO:0000304
name: superoxide dismutase
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110051#
modifier: MODEL1310110051#

metaM sebcoa c
has only substance units: false
is: HMDB00651
name: sebacoylcoa
initial concentration: 1.0
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM cdpdag hs m
initial amount: NaN
type: Species
has only substance units: false
name: CDP-diacylglycerol(2-)
is: CHEBI:58332
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_e4874cf2_f192_4bef_b57b_002d032822b3
initial concentration: NaN
is encoded by: hsa:2348
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: FOLR1
initial amount: NaN
type: Species

metaM gal c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:0
is: C00124
has only substance units: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247
type: Species
name: D-Galactose
is: HMDB00143
boundary condition: false

metaM gluside hs g
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
initial concentration: 1.0
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
is: SBO:0000247
type: Species

metaR NODe
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110051#
name: NODe
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_d8fa27f8_4cea_40f2_86e6_894d16ddab81
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2495
is: P02794
type: Species
name: FTH1
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_55978804_170b_4390_8663_38a78799a395
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2542
type: Species
constant: false
is: A8K0S7
initial concentration: NaN
name: SLC37A4

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR APOC LYS BTNP
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proteolysis of apoC-Lys-btn
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_9a037413_10dd_4a96_b2e1_421adc35359b
is: Q16877
initial amount: NaN
name: PFKFB4
constant: false
type: Species
boundary condition: true
is encoded by: hsa:5210
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR DNDPt10m
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
name: dADP transport via dCDP antiport
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110051#_0b034452_9d2a_4949_a0e0_1168f53f58ae
constant: false
type: Species
has only substance units: false
is: Q16739
initial concentration: NaN
is: SBO:0000252
name: UGCG
is encoded by: hsa:7357
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_5c56d73c_b8a4_4240_9576_fedbeffed513
initial amount: NaN
constant: false
is: SBO:0000252
name: FUT8
initial concentration: NaN
type: Species
is encoded by: hsa:2530
has only substance units: false
is: G3V5N0
boundary condition: true

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM h2o g
initial concentration: 1.0
is: HMDB02111
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: water
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false

metaR S2TASE1ly
is version of: http://identifiers.org/ec-code/3.1.6.13
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110051#
name: iduronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction

metaR RTOTAL3FATPc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_2e6e2b52_3a63_4cac_a47a_920ba9458bd6
is encoded by: hsa:293
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: Q6I9V5
name: SLC25A6

metaM gal e
boundary condition: false
is: CHEBI:0
initial concentration: 1.0
is: C00124
constant: false
is: SBO:0000247
type: Species
is: HMDB00143
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
initial amount: NaN
name: D-Galactose

metaR LCADi D
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
product: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
name: lactaldehyde dehydrogenase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR IDOURtly
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
name: iduronate transport into lysososme

http://identifiers.org/biomodels.db/MODEL1310110051#_8da84cb4_de75_4ffd_a8e2_50865c0b28b1
is encoded by: hsa:6309
constant: false
is: Q6GTM5
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: SC5DL

metaR FAOXC141C121m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR ALAGLYexR
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000304
fast: false
is: SBO:0000185
name: L-alanine/glycine reversible exchange
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR FAOXC183C163Gm
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_1f70944a_560d_41e7_b8ee_38f975f8e99e
is encoded by: hsa:57835
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: SLC4A5
is: SBO:0000252
initial amount: NaN
constant: false

metaM nmn c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:14649
initial amount: NaN
has only substance units: false
name: NMN
is: C00455
boundary condition: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
constant: false
type: Species
is: HMDB00229

http://identifiers.org/biomodels.db/MODEL1310110051#_76f0d99c_4f0b_42bc_8fc8_6d847304a909
name: _AI539321_1_c
boundary condition: true
is encoded by: hsa:AI539321
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_5692d170_d686_4a4a_ac73_fe81fc4a4494
has only substance units: false
is: Q96G03
name: PGM2
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:55276
initial concentration: NaN

metaM dhlam m
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
is: SBO:0000247
name: dihydrolipoamide
is: HMDB00985
boundary condition: false
is: CHEBI:17694
initial amount: NaN
type: Species

metaM 3hdcoa c
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB00651
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
is: SBO:0000247
name: (S)-3-Hydroxydecanoyl-CoA
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_e84bf436_e1a7_4971_8f98_5111196a994d
boundary condition: true
has only substance units: false
is: P54687
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:586
constant: false
name: BCAT1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_8f3c9d1b_a413_4e6e_ab25_89f6b49550a7
initial concentration: NaN
name: PPA2
constant: false
is encoded by: hsa:27068
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_b2bf2e39_8826_435b_929a_29d1451d97ff
initial concentration: NaN
is encoded by: hsa:6530
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SLC6A2
is: Q96KH8
type: Species

metaR FAOXC163C164Gm
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR GLNtN1
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
name: Glutamine transport (Na, H coupled)
fast: false
reversible: true
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
is described by: ECO:0000269

metaR BILDGLCURtr
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_2f35f0bc_c7d0_4abf_bb7a_423bdd4e0d05
initial amount: NaN
has only substance units: false
is encoded by: hsa:6519
name: SLC3A1
boundary condition: true
constant: false
is: Q07837
is: SBO:0000252
initial concentration: NaN
type: Species

metaR TDCHOLAte
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
reactant: MODEL1310110051#
fast: false
is: SBO:0000185
product: MODEL1310110051#
name: bile acid intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_3a4095de_5191_4cd7_b743_28a3607c3894
initial concentration: NaN
boundary condition: true
is: Q6LEN6
type: Species
constant: false
is encoded by: hsa:1103
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: CHAT

metaM bhb m
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
initial amount: NaN
is: HMDB00011
is: CHEBI:10983

metaR r0911
reversible: true
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
fast: false
kinetic law: MODEL1310110051#
name: Facilitated diffusion
product: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR FAOXC1811601m
kinetic law: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110051#
name: Beta oxidation fatty acid
product: MODEL1310110051#
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_bdfaeae8_912f_4aa4_bb4a_3f67e71bcb09
is: Q969K7
type: Species
initial amount: NaN
name: TMEM54
is: SBO:0000252
is encoded by: hsa:113452
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaM his L e
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: HMDB00177
type: Species
constant: false
name: L-histidine
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15971
initial concentration: 1.0

metaR DPCOAK
reversible: false
fast: false
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.7.3
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: dephospho-CoA kinase
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaR ENGASE3ly
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_014a9906_9e5e_41e4_b58d_233d823754b2
initial amount: NaN
initial concentration: NaN
has part: C9JPQ8
boundary condition: true
is encoded by: hsa:5095
name: PCCA:PCCB
has only substance units: false
has part: P05166
type: Species
is: SBO:0000297
constant: false
is encoded by: hsa:5096

metaR UAG4E
reactant: MODEL1310110051#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.2
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
name: UDP-N-acetylglucosamine 4-epimerase
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaR r2109
reversible: true
is: SBO:0000185
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR GPIDAer
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
reversible: false
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
modifier: MODEL1310110051#
product: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_3a6353e9_d052_465e_9e17_950163fee307
boundary condition: true
is: P49327
name: FASN
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:2194

http://identifiers.org/biomodels.db/MODEL1310110051#_d63ba383_0e8a_4f5b_aad5_6fe0512a0e43
initial amount: NaN
is: Q9NY65
has only substance units: false
boundary condition: true
constant: false
name: EHHADH
initial concentration: NaN
is encoded by: hsa:1962
is: SBO:0000252
type: Species

metaR r1578
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000185

metaR r0051
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.5
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reactant: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#

metaR FACOAL260
is: SBO:0000176
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
product: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (n-C26:0)
kinetic law: MODEL1310110051#

metaM 6pgl r
type: Species
has only substance units: false
is: HMDB01127
constant: false
is: CHEBI:57955
is: SBO:0000247
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236

http://identifiers.org/biomodels.db/MODEL1310110051#_910af455_a94b_4eff_a15e_5d583965d84f
name: HLCS
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: P50747
boundary condition: true
initial amount: NaN
is encoded by: hsa:3141

http://identifiers.org/biomodels.db/MODEL1310110051#_81f414d0_ecec_4b33_a3a3_17759ae8fad2
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: VNN2
is encoded by: hsa:8875
is: A8K7W0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_cbf4789a_6acb_4f58_b144_4209b7e2f046
has only substance units: false
is encoded by: hsa:2983
is: Q02153
type: Species
constant: false
name: GUCY1B3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR S6TASE2ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_ed8e8580_f3e1_44b8_9b1e_3404951c1b03
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: Q9UI40
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC24A2
is encoded by: hsa:25769

http://identifiers.org/biomodels.db/MODEL1310110051#_3d26fbc7_45c9_42e4_a71a_8e02827bee3f
type: Species
name: _AI348006_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI348006
constant: false

metaM h g
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: proton
has only substance units: false
is: SBO:0000247
is: CHEBI:24636
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR PPDOx
reversible: false
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
modifier: MODEL1310110051#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110051#

metaM udp l
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58223
is: SBO:0000247
is: HMDB00295
boundary condition: false
initial amount: NaN
has only substance units: false
name: UDP(3-)

metaR r0839
is: SBO:0000185
product: MODEL1310110051#
name: Postulated transport reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000000

metaR r1575
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110051#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR r2108
modifier: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110051#

metaM nadh x
is: HMDB01487
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
is: CHEBI:57945
has only substance units: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306

http://identifiers.org/biomodels.db/MODEL1310110051#_fb988e1e_73ca_47fa_bf71_f720ba40e0aa
name: ACP1
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:52
initial concentration: NaN
constant: false
initial amount: NaN
is: B5MCC7
has only substance units: false

metaR r0913
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110051#

metaM ksii core2 pre9 g
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
constant: false
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 9
type: Species
is: CHEBI:28067

metaR C16OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

metaR r2107
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR PPDOy
is described by: ECO:0000269
fast: false
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.21
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR FAOXC2242046m
type: Reaction
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_52bceed9_a216_4294_972e_c94e0e40996c
constant: false
name: PIGO
is encoded by: hsa:84720
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q8TEQ8
boundary condition: true
type: Species
initial concentration: NaN

metaR r0838
type: Reaction
fast: false
is described by: ECO:0000000
name: Free diffusion
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reversible: true

metaM c4crn m
is: HMDB02013
has only substance units: false
name: butyryl carnitine
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: C02862
constant: false
boundary condition: false

metaR r0276
kinetic law: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
modifier: MODEL1310110051#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
reversible: true
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000000

metaR r1576
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110051#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_5daa8cbe_8e5a_48f0_8aaa_dd7adb5b895c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: MPST
is encoded by: hsa:4357
is: P25325
has only substance units: false

metaR CLS hs
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176
name: cardiolipin synthase (homo sapiens)
fast: false
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
is described by: ECO:0000000

metaM dhbpt c
constant: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: CHEBI:20680
is: HMDB00038
initial amount: NaN
boundary condition: false
has only substance units: false
name: 6,7-dihydrobiopterin
type: Species
initial concentration: 1.0

metaM crn c
initial concentration: 1.0
is: CHEBI:16347
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: L-Carnitine
type: Species
is: C00318
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaM h m
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
name: proton
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:24636
is: C00080
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3380
type: Species

metaR CATm
modifier: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES:TV
is version of: http://identifiers.org/ec-code/1.11.1.6
fast: false
name: catalase
reactant: MODEL1310110051#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
type: Reaction

metaR r1573
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_31679f98_50a5_4901_ba4d_902ff1e28f66
initial amount: NaN
is encoded by: hsa:7298
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P04818
name: TYMS
type: Species

metaR AHCYSte
reversible: true
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
name: Transport of S-adenosyl-L-homocysteine

http://identifiers.org/biomodels.db/MODEL1310110051#_345e3d90_3d86_4f29_a5aa_eb886e490329
boundary condition: true
has only substance units: false
constant: false
type: Species
name: COX7C
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1350
initial amount: NaN
is: P15954

metaM udp n
boundary condition: false
constant: false
type: Species
has only substance units: false
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
initial concentration: 1.0
initial amount: NaN
is: HMDB00295
is: SBO:0000247

metaM CE4872 m
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:15748
initial amount: NaN
is: HMDB00127
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_2c46770e_261d_4c53_a4e5_21784953d1c1
name: ELOVL6
is: SBO:0000252
is: Q9H5J4
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:79071
has only substance units: false

metaR RE2626C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
product: MODEL1310110051#
name: RE2626
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR r2106
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110051#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaM tetd7ecoa m
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: 7-tetradecenoylcoa
is: HMDB13109
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_53921d38_d7f3_46d2_bc8c_57d2aa2e8bad
is: C9JT23
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:126328
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: NDUFA11

metaM h n
name: proton
is: SBO:0000247
is: CHEBI:24636
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_54db6a50_5984_4db5_880a_119b39374709
is encoded by: hsa:J03866
boundary condition: true
name: _J03866_1_m
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaM dudp c
is: HMDB01000
name: dUDP
is: CHEBI:60471
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C01346
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ada5d8b6_5d3d_459b_a32b_5d5da01be80a
initial amount: NaN
is encoded by: hsa:66035
initial concentration: NaN
is: Q8WXF9
has only substance units: false
name: SLC2A11
constant: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_5ec99b3f_3e70_4fa6_a87c_ee67be548f64
name: COX6B1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P14854
is: SBO:0000252
is encoded by: hsa:1340
constant: false
initial amount: NaN
type: Species

metaM adrn c
is: SBO:0000247
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
name: adrenic acid
initial concentration: 1.0
constant: false
is: CHEBI:53487
is: HMDB02226
boundary condition: false
type: Species
initial amount: NaN

metaM prpncoa m
is: HMDB02307
initial concentration: 1.0
type: Species
is: SBO:0000247
name: acryloyl-CoA(4-)
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57367
has only substance units: false

metaM fad c
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: C00016
boundary condition: false
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01248
type: Species

metaR CSAPASEly
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110051#
reversible: false

metaM occoa m
is: CHEBI:57386
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
initial concentration: 1.0
has only substance units: false
is: HMDB01070
type: Species
constant: false
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247

metaR r1574
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_6947aafc_daaf_4cbf_82b3_f65f1b5c4fd9
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6524
is: P31639
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC5A2

http://identifiers.org/biomodels.db/MODEL1310110051#_54858c5a_370d_436e_b731_423df2883885
is encoded by: hsa:10637
is: O75610
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: LEFTY1
boundary condition: true

metaM nadh r
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
has only substance units: false
type: Species
is: CHEBI:57945
name: NADH(2-)
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

metaR r0836
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_cec2a7c6_c255_457b_83d4_db8db2340e33
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM etoh x
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial amount: NaN
is: HMDB00108
name: ethanol
is: CHEBI:16236
has only substance units: false

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110051#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#

metaR RAI1
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
reversible: true
name: retinal isomerase (11-cis)
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR CRVNCtr
name: fatty acid transport via diffusion
reversible: true
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_bfb6d428_099a_4fce_b0d6_2e37bbac66d2
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q03393
boundary condition: true
is encoded by: hsa:5805
type: Species
name: PTS
has only substance units: false

metaM crn e
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
is: C00318
name: L-Carnitine
is: HMDB00062
initial amount: NaN

metaR r1571
reversible: true
reactant: MODEL1310110051#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110051#
is: SBO:0000185

metaR ACP1 FMN
name: acid phosphatase (FMN)
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
reactant: MODEL1310110051#
type: Reaction
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
kinetic law: MODEL1310110051#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110051#_5586b0dd_139a_4237_b98a_798d7931b77e
initial amount: NaN
type: Species
name: ENTPD3
has only substance units: false
constant: false
is: O75355
boundary condition: true
is encoded by: hsa:956
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_b5f8f45d_1942_47e4_af14_8e174f3c63f5
is encoded by: hsa:3162
type: Species
is: SBO:0000252
constant: false
is: Q6FH11
initial concentration: NaN
initial amount: NaN
name: HMOX1
boundary condition: true
has only substance units: false

metaR DNDPt21m
reactant: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: dTDP transport via ADP antiport
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false

metaR r0835
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
product: MODEL1310110051#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000

metaR ITCOALm
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
reactant: MODEL1310110051#
is described by: ECO:0000212
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
fast: false

metaR r2104
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM ksi deg17 l
boundary condition: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: CHEBI:12936
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 17
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00143

metaM fad e
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01248
type: Species
has only substance units: false
is: C00016
initial amount: NaN
is: CHEBI:16238
boundary condition: false

metaM ksii core2 pre6 g
has only substance units: false
type: Species
is: CHEBI:28067
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_30ba7590_44b0_4914_a9af_4d4336cda1d4
is encoded by: hsa:2530
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: FUT8
is: Q546E0
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR DECCRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaR ELAIDt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110051#
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#

metaR C4STMO2Pr
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
modifier: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
kinetic law: MODEL1310110051#
name: C-4 methyl sterol oxidase
reversible: false

metaM adrn e
has only substance units: false
is: CHEBI:53487
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
initial amount: NaN
initial concentration: 1.0
name: adrenic acid
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_5dcbd00e_e84a_4100_a235_97595e693c17
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: P38571
is encoded by: hsa:3988
has only substance units: false
name: LIPA

metaR AHCYStd
fast: false
type: Reaction
name: diffusion of S-Adenosyl-L-homocysteine
kinetic law: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reversible: true
reactant: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000134

metaR FALDtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110051#
fast: false
reversible: true
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: formaldehyde transport via diffusion (lysosomall)
reactant: MODEL1310110051#

metaR FAOXC11C9m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_4961dfa7_de7e_4020_9dca_7ac27255efaf
initial amount: NaN
is: SBO:0000252
name: NDUFA9
is: Q16795
is encoded by: hsa:4704
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR r0400
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false

metaM h l
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
name: proton
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247

metaM thcrm hs g
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:24636
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial amount: NaN
name: trihexosyl ceramide
constant: false
type: Species

metaM his L c
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: HMDB00177
initial amount: NaN
boundary condition: false
name: L-histidine
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:15971

http://identifiers.org/biomodels.db/MODEL1310110051#_15655a17_52d9_4591_9ed1_ace15af95a58
is: Q99643
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6391
has only substance units: false
name: SDHC
constant: false
initial concentration: NaN

metaR r2103
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110051#

metaR THRASNNaEx
modifier: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_ba51f9fe_22b7_43d3_8a9c_f3cec5f05185
type: Species
name: SLC46A1
initial amount: NaN
has only substance units: false
is encoded by: hsa:113235
boundary condition: true
is: SBO:0000252
is: Q96NT5
constant: false
initial concentration: NaN

metaM dmnoncoa x
boundary condition: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: HMDB11604
is: SBO:0000247
has only substance units: false
name: 4,8 dimethylnonanoyl-CoA
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_dc1fe086_6eb5_46c2_adcc_1e98ce2e3f20
has only substance units: false
is: SBO:0000252
constant: false
name: HLCS
is encoded by: hsa:3141
is: P50747
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_13db089a_dd72_4613_b26c_ffc100bd4cb1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7108
is: O76062
has only substance units: false
type: Species
boundary condition: true
constant: false
name: TM7SF2

metaR ADNCYC
kinetic law: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.6.1.1
type: Reaction
is described by: ECO:0000269
product: MODEL1310110051#
name: adenylate cyclase
reversible: false
fast: false
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
reactant: MODEL1310110051#

metaM 3mob e
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
type: Species
is: CHEBI:11851
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1

http://identifiers.org/biomodels.db/MODEL1310110051#_a5f20097_b77e_4df9_833a_2502721ae32c
type: Species
name: B3GALNT1
is: Q8TDY1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8706
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_6f4ec16a_7a28_4aa5_a7ab_68e056f84c9d
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:W74642
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: _W74642_1_c

http://identifiers.org/biomodels.db/MODEL1310110051#_499d106a_cc86_4e1e_a65b_4c35c6798465
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9BVG9
name: PTDSS2
is encoded by: hsa:81490
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_7953c065_702b_4591_a9f2_47d44827ac01
constant: false
has only substance units: false
is encoded by: hsa:6553
initial amount: NaN
is: SBO:0000252
type: Species
name: SLC9A5
initial concentration: NaN
is: Q9NSW9
boundary condition: true

metaR GLCt1r
product: MODEL1310110051#
fast: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110051#
reversible: true
name: glucose transport (uniport)
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

metaR ACONTm
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
reactant: MODEL1310110051#
name: Aconitate hydratase
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical

http://identifiers.org/biomodels.db/MODEL1310110051#_70d231bd_d557_48a2_bdd7_0b82fbded327
is encoded by: hsa:4967
is: Q02218
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: OGDH
has only substance units: false
constant: false

metaM glc D e
is: CHEBI:4167
name: D-glucose
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
is: SBO:0000247
is: HMDB00122
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_c8174752_c158_4bfc_b9bc_e440d041dc8c
name: PPAP2A
is: SBO:0000252
is encoded by: hsa:8611
constant: false
type: Species
is: G3XA95
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR FAOXTC142TC122m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_fedb6cda_d2dc_4803_b3c5_f049641b28b8
name: CAT
has only substance units: false
is: P04040
constant: false
is encoded by: hsa:847
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM strdnccoa c
is: http://identifiers.org/pubchem.compound/47205473
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB06519
name: stearidonyl coenzyme A
constant: false
is: C16163
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110051#_b1af2065_612e_4562_80ca_ce77a66d7dfe
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:AI222095
initial concentration: NaN
name: _AI222095_1_e

http://identifiers.org/biomodels.db/MODEL1310110051#_81d481a4_4676_4956_91b0_85b6bc768afe
boundary condition: true
constant: false
name: LTA4H
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: P09960
is encoded by: hsa:4048
initial amount: NaN

metaR PGCD
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
fast: false
reversible: false
name: phosphoglycerate dehydrogenase
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.95

metaM m2mpdol L c
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
initial concentration: 1.0
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
initial amount: NaN
is: CHEBI:28049
type: Species
boundary condition: false
has only substance units: false

metaM mi13p c
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
is: CHEBI:18225
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB06234
initial concentration: 1.0
name: 1D-myo-Inositol 1,3-bisphosphate
boundary condition: false

metaR DGCHOLte
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_8c673594_0cad_4c74_ac82_c115c115e823
is: SBO:0000252
is: P15121
constant: false
initial amount: NaN
is encoded by: hsa:231
name: AKR1B1
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaM h r
is: http://identifiers.org/pubchem.compound/3380
constant: false
is: C00080
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: CHEBI:24636
name: proton
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM hs deg8 l
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: heparan sulfate, degradation product 8
is: CHEBI:16126
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
initial amount: NaN
type: Species
has only substance units: false

metaR HISTAtu
product: MODEL1310110051#
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110051#
is: SBO:0000185
name: Histamine uniport
fast: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaR RE2986X
notes: GENE_ASSOCIATION: (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: RE2986
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM guln c
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB03290
initial amount: NaN
is: CHEBI:13115
has only substance units: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
constant: false
is: SBO:0000247
name: L-gulonate

metaR ELAIDCRNt
fast: false
modifier: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)

http://identifiers.org/biomodels.db/MODEL1310110051#_c1017dad_46ac_45a1_ac53_7ec295acc715
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:7296
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: TXNRD1

metaR FUM
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
name: fumarase
reversible: true
kinetic law: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_197a6d3c_e58b_4807_a67c_0983260a2617
boundary condition: true
has only substance units: false
constant: false
name: ABCC5
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10057
initial amount: NaN

metaR LNLNCACRNt
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110051#
name: transport into the mitochondria (carnitine)
fast: false
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000269
kinetic law: MODEL1310110051#
reversible: false
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_4082a9fc_01e1_4798_9035_b5ad190488ca
initial amount: NaN
constant: false
is encoded by: hsa:4166
boundary condition: true
is: Q9GZX3
name: CHST6
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_9477a618_aa3d_4305_86f6_ce290c99a0c7
type: Species
constant: false
is encoded by: hsa:6487
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ST3GAL3

metaM udp c
is: C00015
boundary condition: false
is: SBO:0000247
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: HMDB00295
type: Species
is: CHEBI:58223
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM nh4 x
type: Species
has only substance units: false
name: Ammonium
boundary condition: false
is: HMDB00051
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
is: C01342
constant: false
initial concentration: 1.0
is: CHEBI:28938

metaM 3mob c
is: HMDB00019
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
type: Species
is: CHEBI:11851
has only substance units: false

metaM lneldccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB06461
boundary condition: false
constant: false
initial concentration: 1.0
name: Linoelaidyl carnitine

metaR FAOXC181C161x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_64c699e8_ef86_4eb0_a421_ba1e41ad85da
has only substance units: false
name: NDUFB9
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4715
is: SBO:0000252
is: Q9Y6M9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_232d4e4f_8578_4d67_a993_00b8282dc227
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: PPAP2C
is encoded by: hsa:8612
is: SBO:0000252
initial concentration: NaN
is: E9PAY8

metaR THRALANaEx
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110051#_e5235625_c2fa_4399_8469_5f684e7143b5
boundary condition: true
is encoded by: hsa:65010
initial concentration: NaN
has only substance units: false
name: SLC26A6
is: SBO:0000252
initial amount: NaN
is: Q9NQU1
constant: false
type: Species

metaR r0830
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110051#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR AG13T2g
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR PVD3
reactant: MODEL1310110051#
is described by: ECO:0000134
fast: false
name: Previtamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reversible: true
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_288dc871_3a60_4248_8fd5_d372ce4a9b18
name: _AI971036_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI971036
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_a31ff034_5d75_48ab_b19a_1c2949852fd3
is encoded by: hsa:130
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P28332
constant: false
initial concentration: NaN
name: ADH6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_82f33682_db66_499c_8909_307ddbf16ca1
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC26A7
initial amount: NaN
is: Q8TE54
has only substance units: false
type: Species
is encoded by: hsa:115111

metaM glc D c
name: D-glucose
has only substance units: false
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00122
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_4591fedc_c7a5_4219_87ef_64013f818051
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: HSD3B1
is: P14060
is encoded by: hsa:3283
initial amount: NaN
has only substance units: false

metaM 2dodtricoa m
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: HMDB11123
has only substance units: false
is: C05279
initial concentration: 1.0
name: 2,6,9-dodecatrienoylcoa
constant: false
type: Species
is: SBO:0000247

metaM pail34p hs c
is: SBO:0000247
type: Species
is: CHEBI:57658
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
has only substance units: false
boundary condition: false

metaM m4masn g
is: C05881
initial amount: NaN
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_cdf4fc41_e7b3_4f99_b644_daf96df8fa0e
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AA203143
name: _AA203143_1_c
type: Species

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM 3tdcrn e
name: 3-hydroxy-tetradecanoyl carnitine
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C21H41NO5 CHARGE: 0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB13336

http://identifiers.org/biomodels.db/MODEL1310110051#_0f23affe_4069_4f0b_a787_3abf7fbdcf9b
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: PDE9A
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252

metaR FAOXC102C81m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR GTHOm
kinetic law: MODEL1310110051#
name: glutathione oxidoreductase
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: false
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is: SBO:0000176

metaM CE2431 m
name: cis-deca-4-enoyl-CoA
initial amount: NaN
boundary condition: false
is: CHEBI:57795
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: SBO:0000247

metaR SUCCCROT
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_144af756_553b_4271_a0da_d17efbe339e7
is encoded by: hsa:11254
is: SBO:0000252
name: SLC6A14
type: Species
constant: false
is: Q9UN76
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR PIK3
is: SBO:0000176
modifier: MODEL1310110051#
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.137
fast: false
type: Reaction
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD

metaM m4mpdol L c
constant: false
initial amount: NaN
is: CHEBI:37633
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false

metaM decdicrn e
notes: FORMULA: C17H29NO4 CHARGE: 0
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB13325
name: decadienoyl carnitine
boundary condition: false
type: Species
is: SBO:0000247

metaM udp e
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:58223
is: HMDB00295

metaM ksi deg32 l
type: Species
is: HMDB00143
initial concentration: 1.0
constant: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
is: CHEBI:12936
has only substance units: false
name: keratan sulfate I, degradation product 32
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR BTND1
type: Reaction
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
is described by: ECO:0000269
is: SBO:0000176
name: biotinidase (biotin)
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaM ksi pre15 g
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00175
is: CHEBI:58053
type: Species
constant: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 15
initial concentration: 1.0
is: C00130

metaR OCTAt
reactant: MODEL1310110051#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110051#
name: Octanoate transport via diffusion
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR

metaR FAOXC121C10x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_37c142ea_2f1f_4d34_a5d2_0f2b08cb5104
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:51227
name: PIGP

http://identifiers.org/biomodels.db/MODEL1310110051#_91b23d6f_6f55_41be_9ac7_b630256b7ea2
is: Q8TD20
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC2A12
has only substance units: false
is encoded by: hsa:154091
type: Species

metaR KSII CORE2t
name: keratan sulfate II (core2) transport, golgi to extracellular
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_86c8c00a_8144_43c2_bda1_ee2147794ec9
initial amount: NaN
initial concentration: NaN
is: A6NN98
boundary condition: true
name: MTMR2
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:8898
constant: false

metaR r1579
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE2996X
kinetic law: MODEL1310110051#
is: SBO:0000176
name: RE2996
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.34
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaM dudp n
is: SBO:0000247
name: dUDP(3-)
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
is: HMDB01000
initial amount: NaN
is: CHEBI:60471
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_bb8407d1_a1c7_4041_a6e8_68ce80883c7b
is encoded by: hsa:5281
boundary condition: true
is: SBO:0000252
is: Q07326
constant: false
type: Species
initial concentration: NaN
name: PIGF
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_9c46aacc_69e3_4caa_ae1e_340432487242
type: Species
initial amount: NaN
name: LSS
initial concentration: NaN
has only substance units: false
constant: false
is: E9PEI9
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4047

metaR NACHEX24ly
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110051#
reversible: false

metaM nadh m
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
constant: false
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57945
is: C00004
is: SBO:0000247
is: HMDB01487
type: Species

metaM 3tdcrn c
boundary condition: false
is: HMDB02014
initial concentration: 1.0
notes: FORMULA: C21H41NO5 CHARGE: 0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: 3-hydroxy-tetradecanoyl carnitine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_29e38ecf_a0ca_4d00_92cf_c834620fd36c
name: PFKFB3
is encoded by: hsa:5209
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: Q16875
is: SBO:0000252
boundary condition: true

metaM decdicrn c
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: decadienoyl carnitine
boundary condition: false
is: HMDB13325
type: Species
notes: FORMULA: C17H29NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110051#_cee2280d_7ffe_4a02_af2c_9d0a276d22ea
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: GCDH
is encoded by: hsa:2639
is: Q92947
constant: false
has only substance units: false
initial concentration: NaN

metaR CHOLK
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Choline kinase
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000269
product: MODEL1310110051#

metaM tdchola x
name: taurochenodeoxycholate
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00951
initial amount: NaN
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
boundary condition: false

metaM udp g
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58223
boundary condition: false
is: HMDB00295

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaR ME1m
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
name: malic enzyme (NAD), mitochondrial

metaM fad m
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16238
is: SBO:0000247
is: C00016
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
name: Flavin adenine dinucleotide oxidized
is: HMDB01248

metaM phyt2ohcoa x
has only substance units: false
name: 2-hydroxyphytanoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57334
is: HMDB01295
constant: false
boundary condition: false
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
type: Species

metaR FAOXC225C226m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR BDHm
reactant: MODEL1310110051#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.30
kinetic law: MODEL1310110051#
reversible: true
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110051#

metaM dudp m
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB01000
initial concentration: 1.0
name: dUDP(3-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471

http://identifiers.org/biomodels.db/MODEL1310110051#_c1dd9ec8_92dc_4b25_a83e_21ac54434c98
type: Species
is: SBO:0000252
name: _N63787_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:N63787

metaM C04849 e
is: SBO:0000247
initial amount: NaN
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate

metaM fe2 e
boundary condition: false
is: HMDB00692
is: SBO:0000247
has only substance units: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial amount: NaN
type: Species
is: CHEBI:29033
name: Fe2+
constant: false
initial concentration: 1.0
is: C00023

metaR RE0926E
type: Reaction
is: SBO:0000176
name: RE0926
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false

metaR SARCStex
is: SBO:0000185
type: Reaction
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
reversible: false
is described by: ECO:0000000
name: Sarcosine transport (extracellular to cytosol)
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR P4508B11r
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110051#
name: sterol 12-alpha-hydroxylase
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.14.13.95
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)

http://identifiers.org/biomodels.db/MODEL1310110051#_05506448_b047_4719_b925_feffa4b2aec6
has only substance units: false
initial concentration: NaN
is encoded by: hsa:48
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: P21399
name: ACO1
is: SBO:0000252

metaM HC02217 e
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
name: prostaglandin-g2
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM 6pgl c
is: HMDB01127
notes: FORMULA: C6H9O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57955
type: Species
has only substance units: false
is: SBO:0000247
is: C01236
initial amount: NaN
name: 6-phospho-D-glucono-1,5-lactone

metaM 5fthf m
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
constant: false
is: CHEBI:57457
name: 5-formyltetrahydrofolate(2-)
is: HMDB01562
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_2abe7346_3b1b_461e_a801_d38be4b9a9ed
is: Q14442
is: SBO:0000252
name: PIGH
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5283
type: Species
initial amount: NaN
constant: false

metaR r0614
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
fast: false
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_09bb5ebf_7196_45a2_9b59_90748488f1a3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: SYNJ1
is encoded by: hsa:8867
initial amount: NaN
is: O43426
has only substance units: false
type: Species

metaR OMPDC
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.10
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000176
name: orotidine-5'-phosphate decarboxylase
modifier: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction

metaR NACHEX26ly
type: Reaction
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110051#
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110051#_b6ffc3f8_a501_49a4_8476_ac0b767a1aa4
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: SLC4A5
has only substance units: false
is encoded by: hsa:57835
constant: false

metaR GALSIDEtl
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110051#
name: galactocerebroside intracellular transport
is described by: ECO:0000000
reversible: true

metaR ACCOAC
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM galgluside hs g
is: C00015
initial concentration: 1.0
has only substance units: false
is: CHEBI:58223
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
type: Species
name: galactosyl glucosyl ceramide
initial amount: NaN
is: HMDB00295
constant: false
is: SBO:0000247

metaM occoa x
constant: false
type: Species
is: SBO:0000247
is: CHEBI:57386
has only substance units: false
initial concentration: 1.0
is: C01944
is: HMDB01070
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_da1e741b_5364_423b_bd44_36154de4963f
is: SBO:0000252
has only substance units: false
name: SLC19A3
is: Q9BZV2
initial concentration: NaN
constant: false
is encoded by: hsa:80704
type: Species
initial amount: NaN
boundary condition: true

metaR EICOSTETCRNt
is: SBO:0000185
fast: false
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
reversible: false
product: MODEL1310110051#

metaM 3mob m
is: CHEBI:11851
constant: false
name: 3-methyl-2-oxobutanoate
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00019
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

metaR LEUPHELAT2tc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR 3HBCOAHLm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
fast: false
is: SBO:0000176
reactant: MODEL1310110051#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction

metaM nh4 n
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: ammonium
constant: false
has only substance units: false
is: CHEBI:28938
type: Species

metaR DM ethamp r
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_703f2774_ddca_4ca4_8b47_79c35f72df34
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AL048840
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: _AL048840_1_c
has only substance units: false

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaM fad x
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
constant: false
has only substance units: false
initial concentration: 1.0

metaM h x
is: CHEBI:24636
initial amount: NaN
type: Species
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
name: proton

metaM fe2 c
is: C00023
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692
is: SBO:0000247
type: Species
initial amount: NaN
name: Fe2+
is: CHEBI:29033
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_9e570aa0_d185_4dfd_a5de_ff02be7dd2cb
has only substance units: false
type: Species
initial amount: NaN
is: Q9UHI7
is: SBO:0000252
name: SLC23A1
constant: false
is encoded by: hsa:9963
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_dca84c65_9097_46a3_b904_e4fa39c9a300
boundary condition: true
is: Q9H6Y6
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: MYO5B
is encoded by: hsa:4645
has only substance units: false
constant: false

metaM thbpt c
is: SBO:0000247
constant: false
is: HMDB00027
initial amount: NaN
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
type: Species
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR RE0958E
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0958
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
reversible: true
product: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.17

metaR FAOXC226
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110051#
product: MODEL1310110051#

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_e24cd1b9_c641_4bb0_8cb0_6f18af98eca2
constant: false
initial concentration: NaN
type: Species
is: Q7KYS4
initial amount: NaN
has only substance units: false
is encoded by: hsa:5143
boundary condition: true
name: PDE4C
is: SBO:0000252

metaM ksi deg14 l
type: Species
constant: false
is: CHEBI:12936
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00143
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
name: keratan sulfate I, degradation product 14

metaM strdnccoa m
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06519
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
name: stearidonyl coenzyme A
is: C16163
type: Species
is: http://identifiers.org/pubchem.compound/47205473
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_27105d24_0287_4044_841c_4d5309014756
type: Species
is: Q9NRA0
initial concentration: NaN
name: SPHK2
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:56848
initial amount: NaN
is: SBO:0000252

metaR GBSIDEtl
reversible: true
type: Reaction
kinetic law: MODEL1310110051#
name: globoside intracellular transport
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_567ef63a_2c99_4138_bc47_1b53873c6ab8
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: B3KWF4
initial amount: NaN
initial concentration: NaN
name: GALNT11
is encoded by: hsa:63917

metaR MMTSADm
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110051#
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human

metaM crn r
name: (R)-carnitine
initial amount: NaN
is: CHEBI:16347
is: HMDB00062
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species

metaR GACPAILter
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: glucosaminyl-acylphosphatidylinositol ER flippase
is: SBO:0000185
kinetic law: MODEL1310110051#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_bb2c0370_4f74_4985_84e9_0c962d31d9ea
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: Q53Y41
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1644
initial concentration: NaN
name: DDC

metaR RE1521M
reversible: true
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1521
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000

metaM c4crn x
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: butyryl carnitine
is: C02862
is: HMDB02013
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_ff7779c0_76a1_4411_8dbb_4adb56955d44
is encoded by: hsa:9380
is: Q9UBQ7
boundary condition: true
name: GRHPR
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM CE1944 c
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36781
is: SBO:0000247
type: Species
has only substance units: false
name: 1-pyrrolinium
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a70bd5d5_72b1_4744_95f9_4e28731dc6c1
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: GALK2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2585
has only substance units: false
is: Q01415

metaR r1433
reversible: false
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
type: Reaction
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_f80766b1_34c0_4566_a444_d291e7a1ffe9
constant: false
is: E9PDD5
initial concentration: NaN
name: IDH3G
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:3421

metaR NACHEX15ly
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
fast: false
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_a7cebc84_d02d_4d17_924c_84eb67802f48
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1632
name: ECI1
is: P42126
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaR PCHOL HStg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
name: phosphatidylcholine scramblase
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
type: Reaction
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_31076b46_549b_494d_b802_83fb0e18c70b
has only substance units: false
name: NDUFB7
boundary condition: true
is: P17568
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4713

metaR 34DHXMANDACOX
kinetic law: MODEL1310110051#
is: SBO:0000176
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
product: MODEL1310110051#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
type: Reaction
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000269

metaM trdox m
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
initial concentration: 1.0

metaM tetpent3 c
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB06323
name: tetracosapentaenoic acid, n-3
constant: false
boundary condition: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaR RE2954C
is described by: ECO:0000000
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
name: RE2954
is: SBO:0000176

metaM galgluside hs c
name: galactosyl glucosyl ceramide
has only substance units: false
boundary condition: false
is: HMDB06535
type: Species
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_b61719e8_11e0_4aaf_b434_fd9ef1c6c1b8
initial concentration: NaN
has part: B4E3E9
initial amount: NaN
boundary condition: true
type: Species
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:4967
constant: false
is: SBO:0000297
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_634b08f8_29b0_4d29_bb87_29f563c654c4
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:BF195998
name: _BF195998_1_x
type: Species
is: SBO:0000252

metaM lnlc c
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00673
name: linoleate
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
has only substance units: false

metaM c226crn c
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: cervonyl carnitine
initial concentration: 1.0
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06510
is: http://identifiers.org/pubchem.compound/127055
is: SBO:0000247

metaR URATEt
name: urate export from cytosol
kinetic law: MODEL1310110051#
reversible: false
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110051#

metaM cgly e
constant: false
has only substance units: false
is: CHEBI:4047
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00078
name: L-cysteinylglycine
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

http://identifiers.org/biomodels.db/MODEL1310110051#_39bd84a5_6ddc_4513_a9e6_ff2b51834fcb
name: ALDH7A1
is: SBO:0000252
boundary condition: true
is: E7EPT3
type: Species
constant: false
is encoded by: hsa:501
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaM nadh c
has only substance units: false
is: C00004
is: HMDB01487
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced

metaR EICOSTETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110051#
name: fatty acid transport via diffusion
reactant: MODEL1310110051#
fast: false
reversible: true
product: MODEL1310110051#

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR r1431
type: Reaction
reactant: MODEL1310110051#
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_a7ec7ee6_091d_461d_bb36_f963d121d49a
is: O00459
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:5296
boundary condition: true
name: PIK3R2
is: SBO:0000252

metaR HSD3B12r
fast: false
type: Reaction
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
product: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: false

metaM ksi pre1 g
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: SBO:0000247
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 1
type: Species
is: C00130
is: HMDB00175
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
boundary condition: false

metaR GALASE16ly
modifier: MODEL1310110051#
name: beta-galactosidase, lysosomal
reversible: false
fast: false
kinetic law: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR PI45P5P
kinetic law: MODEL1310110051#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110051#
is: SBO:0000176
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110051#
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_8460239b_f794_4ff5_bbef_729adcdc5b86
name: ARSB
type: Species
constant: false
initial amount: NaN
is: P15848
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:411

metaM vacccrn c
has only substance units: false
name: Vaccenyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06351
is: SBO:0000247
boundary condition: false

metaR PROSTGF2t
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false

metaM dutp c
is: CHEBI:17625
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01191
initial amount: NaN
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
constant: false
is: C00460

metaM tetpent3 e
name: tetracosapentaenoic acid, n-3
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06323
constant: false
boundary condition: false
initial amount: NaN

metaR SERtN1
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
fast: false
kinetic law: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
name: Serine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110051#_7ca1cf23_2dce_44cd_a585_6b8ffbd9e254
initial concentration: NaN
name: GPT
constant: false
has only substance units: false
is encoded by: hsa:2875
is: SBO:0000252
is: P24298
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_852caf38_e5d0_43e6_b2b3_c8a8997fd6ba
is encoded by: hsa:8883
type: Species
is: A8MU28
constant: false
name: NAE1
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR FADH2ETC
type: Reaction
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110051#
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110051#
name: Complex II reaction for respiratory chain

metaM malthx e
initial concentration: 1.0
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
name: Maltohexaose
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial amount: NaN
constant: false
is: C01936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_c72b9276_69fe_462e_b072_a9cfdfddcbcd
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2639
is: SBO:0000252
boundary condition: true
name: GCDH
is: Q92947

metaR THRGLNexR
product: MODEL1310110051#
reversible: true
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110051#
name: L-threonine/glycine reversible exchange

metaM cgly c
constant: false
is: CHEBI:4047
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: L-cysteinylglycine
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: HMDB00078
has only substance units: false

metaR RE3624M
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
name: RE3624
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110051#
reversible: false

metaR LNELDCCRNt
product: MODEL1310110051#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110051#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR UMPK4n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (GTP),nuclear
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#

metaR r2101
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110051#
reversible: true
product: MODEL1310110051#

metaR LNELDCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110051#
name: fatty acid transport via diffusion
fast: false
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_8c15b012_d13b_43e8_8c75_9e73c353ff54
is: Q96CA6
has only substance units: false
boundary condition: true
is encoded by: hsa:30
is: SBO:0000252
name: ACAA1
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_83419ed8_75af_41ac_b5cf_b83d485744ae
has only substance units: false
is: SBO:0000252
is encoded by: hsa:291
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: SLC25A4
boundary condition: true
is: P12235

metaR FAOXC102C81x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaR r1796
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110051#
type: Reaction
reversible: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR r1570
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_051d1e58_1174_42fb_ac01_261eb93a0ee2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3155
has only substance units: false
constant: false
is: Q6IBC0
type: Species
name: HMGCL

metaM 2decdicoa m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: 2,7-decadienoylcoa
is: SBO:0000247

metaM Rtotal e
is: HMDB00244
is: CHEBI:3554
name: R total
constant: false
notes: FORMULA: CO2FULLR CHARGE: -1
has only substance units: false
is: SBO:0000247
is: C00255
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM 3oddcoa m
is: HMDB03937
has only substance units: false
constant: false
is: CHEBI:27868
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
initial amount: NaN
name: 3-Oxododecanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR CYTK14n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000269

metaM udp r
is: C00015
has only substance units: false
is: CHEBI:58223
name: UDP
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM bhb e
boundary condition: false
name: (R)-3-hydroxybutyrate
constant: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
is: HMDB00011
is: CHEBI:10983
initial amount: NaN
type: Species
initial concentration: 1.0

metaM nh4 e
type: Species
name: ammonium
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
has only substance units: false
is: HMDB00051
constant: false
boundary condition: false

metaR r2102
product: MODEL1310110051#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_1b20acff_e5e3_4e05_bc1e_a9f6b58cad52
type: Species
is encoded by: hsa:206
initial amount: NaN
constant: false
is: SBO:0000252
name: _206_1_c
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM HC01610 e
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:28607
boundary condition: false
name: CoproporphyrinogenI
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial concentration: 1.0
is: SBO:0000247

metaR r1435
reactant: MODEL1310110051#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: Transport reaction
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_aa8b2bf9_ea89_4021_b99e_0247652e4139
is: P07954
is: SBO:0000252
name: FH
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:2271
has only substance units: false
constant: false
initial amount: NaN

metaR GBSIDEte
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
fast: false
is described by: ECO:0000000
name: globoside transport
product: MODEL1310110051#

metaM gdp c
is: C00035
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:58189
is: HMDB01201
boundary condition: false
is: SBO:0000247
name: GDP
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_bbda1d21_5144_4d9b_9b82_02917fbba609
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:112
name: ADCY6
constant: false
is: O43306
type: Species
initial amount: NaN

metaR G14T14g
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110051#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110051#_8dee0818_73fd_41ca_a5f9_848f4349bc9f
boundary condition: true
initial amount: NaN
name: SLCO1C1
type: Species
has only substance units: false
is encoded by: hsa:53919
is: Q5JPA4
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r2100
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_16bb69ab_0527_4d34_874d_969013cf79b3
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:57835
initial concentration: NaN
name: SLC4A5
is: SBO:0000252
constant: false
boundary condition: true

metaR r2443
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110051#
reversible: false
is described by: ECO:0000000
product: MODEL1310110051#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is: SBO:0000185
reactant: MODEL1310110051#

metaM homoval m
boundary condition: false
constant: false
has only substance units: false
name: Homovanillate
type: Species
is: HMDB00118
initial amount: NaN
is: CHEBI:545959
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
initial concentration: 1.0
is: SBO:0000247

metaR r1434
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
type: Reaction
name: Transport reaction

metaM lnlc e
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate
constant: false
boundary condition: false
type: Species
is: CHEBI:30245
initial concentration: 1.0
is: HMDB00673

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

metaR GLNTHRNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110051#
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
fast: false
type: Reaction
reactant: MODEL1310110051#

metaR r0618
type: Reaction
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110051#
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000000
fast: false

metaM CE5786 e
boundary condition: false
is: CHEBI:27485
initial amount: NaN
name: kinetensin
constant: false
has only substance units: false
is: HMDB02710
type: Species
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: SBO:0000247
initial concentration: 1.0

metaM 4nphsf c
boundary condition: false
has only substance units: false
is: CHEBI:35422
constant: false
name: 4-Nitrophenyl sulfate
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB06492
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial concentration: 1.0

metaR UGLT
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
product: MODEL1310110051#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.12
is described by: ECO:0000000
modifier: MODEL1310110051#
fast: false

metaM crn m
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
has only substance units: false
is: CHEBI:16347
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00062
name: L-Carnitine
is: SBO:0000247
is: C00318
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_03abd86b_10b9_4140_8038_946b431a0485
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:205
constant: false
name: AK4
type: Species

metaM galgluside hs l
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00143
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: CHEBI:12936
name: galactosyl glucosyl ceramide
has only substance units: false

metaR r0915
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaR TPI
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.3.1.1
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000134
reversible: true
is: SBO:0000176
type: Reaction
name: triose-phosphate isomerase
kinetic law: MODEL1310110051#

metaR DGULND
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
name: dehydro-L-gulonate decarboxylase

metaR ALADGLYexR
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
type: Reaction
name: D-alanine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_3d344cf6_3936_4930_b2cf_0aeffd74bba2
boundary condition: true
name: PPA2
initial amount: NaN
is encoded by: hsa:27068
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaM dutp n
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
is: CHEBI:17625
initial amount: NaN
is: HMDB01191
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r0917
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#

metaR 35CGMPtn
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
name: 35cGMP nuclear transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaM ser D e
is: CHEBI:16523
constant: false
is: SBO:0000247
is: HMDB03406
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
name: D-serine

http://identifiers.org/biomodels.db/MODEL1310110051#_cbb24902_0144_41a8_ab70_accd22de0707
is encoded by: hsa:4833
is: SBO:0000252
type: Species
is: O00746
constant: false
has only substance units: false
name: NME4
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM dutp m
initial amount: NaN
is: CHEBI:17625
has only substance units: false
initial concentration: 1.0
is: HMDB01191
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
constant: false
is: SBO:0000247
name: dUTP
boundary condition: false

metaR FAOXC141C141OHm
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR INSt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
modifier: MODEL1310110051#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
name: Inosine transport (diffusion)
fast: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#

metaR S6T9g
reversible: false
modifier: MODEL1310110051#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR r0616
kinetic law: MODEL1310110051#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_2d84ca58_c7ba_442a_baca_9abb3f1e85af
is encoded by: hsa:2109
name: ETFB
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaM 4nphsf e
constant: false
initial amount: NaN
is: CHEBI:35422
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 4-Nitrophenyl sulfate
type: Species
is: HMDB06492
initial concentration: 1.0
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)

http://identifiers.org/biomodels.db/MODEL1310110051#_d86d34d4_7d13_4fbd_834b_fdbfe7888710
is: SBO:0000252
constant: false
boundary condition: true
name: B4GALT3
type: Species
is encoded by: hsa:8703
is: A8K5Z0
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR GLNALANaEx
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
type: Reaction
modifier: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000269
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185

metaM HC02217 c
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: prostaglandin-g2
constant: false
is: CHEBI:27647

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR NMNATr
is described by: ECO:0000269
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.7.1
name: nicotinamide-nucleotide adenylyltransferase
is: SBO:0000176
product: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110051#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_3d2749e0_0726_4e38_8a1a_e6785cb79222
name: NDUFV2
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4729
type: Species
is: P19404

http://identifiers.org/biomodels.db/MODEL1310110051#_ad8e13f8_437e_42e8_96b5_88389d1c13c4
boundary condition: true
has only substance units: false
is encoded by: hsa:5287
is: SBO:0000252
initial concentration: NaN
is: O00750
constant: false
type: Species
initial amount: NaN
name: PIK3C2B

metaM nh4 m
name: Ammonium
is: C01342
boundary condition: false
is: CHEBI:28938
constant: false
is: SBO:0000247
is: HMDB00051
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_be781118_c004_4b4f_8b8d_c334c803c85c
is encoded by: hsa:5281
name: PIGF:PIGO
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
has part: Q6IB04
constant: false
type: Species
boundary condition: true
is encoded by: hsa:84720
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_edb18daf_295d_4179_91a3_25d87e0f1c63
type: Species
is encoded by: hsa:5144
has only substance units: false
name: PDE4D
constant: false
boundary condition: true
is: Q08499
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR 34DHPLACOX NADP
fast: false
kinetic law: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
product: MODEL1310110051#
is: SBO:0000176
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110051#

metaR ALACYSNaEx
is described by: ECO:0000269
reactant: MODEL1310110051#
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110051#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM dcyt n
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: 2'-deoxycytidine
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
type: Species
is: HMDB00014

metaR TYMSULT
fast: false
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
name: Tyramine Sulfotransferase
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_4e2a7767_1780_450f_b352_63fdb866bcb8
is encoded by: hsa:1376
is: P23786
type: Species
boundary condition: true
has only substance units: false
name: CPT2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ad6883ac_8f4f_4bca_9abe_331a05b1cf76
name: _AI601100_1_m
boundary condition: true
has only substance units: false
is encoded by: hsa:AI601100
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaM trdox c
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: C00343
name: Oxidized thioredoxin
has only substance units: false
is: CHEBI:18191
type: Species
initial concentration: 1.0

metaM bhb c
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00011
type: Species
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
constant: false

metaM ser D c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
is: CHEBI:16523
boundary condition: false
name: D-serine
constant: false
is: SBO:0000247
is: HMDB03406

metaM Rtotal l
type: Species
is: CHEBI:52639
notes: FORMULA: CO2FULLR CHARGE: -1
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: R total
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_fc8044c7_921e_49ae_9c04_e170f9dbe3c9
initial concentration: NaN
is: Q6PXP3
name: SLC2A7
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:155184

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#

metaR RE2626M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
reversible: true
modifier: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
product: MODEL1310110051#
name: RE2626

metaM pentcoa m
initial concentration: 1.0
is: C00888
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
constant: false
has only substance units: false
type: Species
is: HMDB13037
name: pentanoylcoa
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_789cf181_5b25_4167_9763_53c04235dcb2
name: _AI191472_1_c
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AI191472
has only substance units: false
constant: false
initial amount: NaN

metaM pro L m
is: HMDB00162
is: CHEBI:17203
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
has only substance units: false
name: L-proline
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

metaM tdchola c
has only substance units: false
is: HMDB00951
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
is: CHEBI:9407
type: Species
name: taurochenodeoxycholate

metaR r0926
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110051#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
name: Postulated transport reaction
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_8aab221c_07f3_450e_9e1b_23947933b019
initial amount: NaN
has only substance units: false
constant: false
name: MECR
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is: Q9BV79
is encoded by: hsa:51102

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaM thymd e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial amount: NaN
is: CHEBI:17748
type: Species
constant: false
is: HMDB00273
is: C00214
is: SBO:0000247
name: Thymidine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_ceae4bb6_bb5c_432c_8810_5fc44d0daa4d
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57468
boundary condition: true
type: Species
initial concentration: NaN
name: SLC12A5
constant: false
is: Q9H2X9

metaM eicostet c
initial amount: NaN
is: CHEBI:36033
is: SBO:0000247
boundary condition: false
name: eicosatetranoic acid
constant: false
initial concentration: 1.0
is: HMDB02177
notes: FORMULA: C20H31O2 CHARGE: -1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d7fe1c5e_843c_4797_ae8d_53cc83ceb99d
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:23236
name: PLCB1
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR AICART
reactant: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110051#
is described by: ECO:0000269
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
kinetic law: MODEL1310110051#
reversible: true
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3

metaR r1563
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110051#
type: Reaction
fast: false
kinetic law: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM CE5788 e
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
is: HMDB02710
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: kinetensin 1-7
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:27485

metaM cspg b l
is: CHEBI:36005
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: HMDB02183

http://identifiers.org/biomodels.db/MODEL1310110051#_e9d17593_21ed_4dc4_8e04_58b9a5416ada
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:377841
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q5MY95
name: ENTPD8
constant: false

metaR S6TASE19ly
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110051#
is described by: ECO:0000000
kinetic law: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#

metaR GMPtg
reversible: true
fast: false
is: SBO:0000185
name: GMP transport (Golgi)
is described by: ECO:0000269
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#

metaR PYK
name: pyruvate kinase
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110051#
is described by: ECO:0000134
product: MODEL1310110051#
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_1c8a26d5_8577_40ac_a4fe_466fc0c0d72b
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: _AV727634_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AV727634
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_4979888d_2707_4d39_8378_fa5b5a6da323
type: Species
is: SBO:0000252
is encoded by: hsa:229
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ALDOB
is: P05062

http://identifiers.org/biomodels.db/MODEL1310110051#_da303df3_3c2d_4b4a_8604_bf28a3d6f94e
type: Species
is encoded by: hsa:10905
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: MAN1A2
has only substance units: false
is: O60476
boundary condition: true

metaM phyt c
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
name: phytanate
initial concentration: 1.0
is: HMDB00801
type: Species
is: CHEBI:37257
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaR S6TASE22ly
is version of: http://identifiers.org/ec-code/3.4.16.5
name: galactose-6-sulfate sulfatase, lysosomal
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
fast: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110051#
type: Reaction

metaR B3GALT5g
product: MODEL1310110051#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
type: Reaction
modifier: MODEL1310110051#
name: Beta-1,3-galactosyltransferase 5
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110051#_c33f10ce_13ed_462b_bb90_5a44b91dc015
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9NPC4
type: Species
is: SBO:0000252
is encoded by: hsa:53947
name: A4GALT
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_1e30eb7f_e2ed_40e1_a4a3_23b3cdcc5210
is: Q8N695
constant: false
name: SLC5A8
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:160728

metaR r1564
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_16f34af7_10e4_42a2_8f0a_3a817c97a828
initial amount: NaN
is: P16278
is encoded by: hsa:2720
boundary condition: true
is: SBO:0000252
name: GLB1
constant: false
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_9d85de0f_5344_4366_b9c7_cfaa1ef46fd7
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4706
name: NDUFAB1
type: Species
is: O14561
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaR r0924
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15209530 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.204.5
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
is described by: ECO:0000000

metaM tdchola e
name: taurochenodeoxycholate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
is: HMDB00951

metaM thymd c
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: C00214
is: SBO:0000247
is: HMDB00273
initial amount: NaN
boundary condition: false
name: Thymidine
is: CHEBI:17748

metaM rbt c
type: Species
initial concentration: 1.0
is: HMDB00508
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
is: CHEBI:15963
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM hx2coa x
boundary condition: false
is: C05998
type: Species
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188
name: trans-Hex-2-enoyl-CoA

metaR SUCCOAPET
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_dc86e172_5dd2_41d4_b199_e6ff1f9030ed
boundary condition: true
type: Species
name: IDH3A:IDH3B:IDH3G
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:3420

metaR r1565
reactant: MODEL1310110051#
reversible: true
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110051#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM eicostet e
is: CHEBI:36033
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: eicosatetranoic acid
is: HMDB02177
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1

metaM pac c
initial concentration: 1.0
name: phenylacetate
initial amount: NaN
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
has only substance units: false
is: HMDB00209
is: SBO:0000247
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_cac3c817_6575_4407_a365_bba34de29f0f
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AU149534
name: _AU149534_1_c

metaM ksii core4 deg4 l
is: CHEBI:57455
initial concentration: 1.0
is: HMDB01354
name: keratan sulfate II (core 4-linked), degradation product 4
boundary condition: false
notes: FORMULA: C66H108N6O48SX CHARGE: -1
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR DPCOAtl
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: dephospho-CoA transport from lysosome via diffusion
type: Reaction
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM ksi deg6 l
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 6
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM phyt e
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
initial concentration: 1.0
is: CHEBI:37257
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00801
name: phytanate
type: Species
is: SBO:0000247

metaR 34HPPte
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110051#
product: MODEL1310110051#

metaM gdp m
has only substance units: false
name: GDP
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
initial concentration: 1.0
boundary condition: false
is: C00035
is: HMDB01201
initial amount: NaN
is: CHEBI:58189

metaR r0829
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.37
reversible: true
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_bf7e47e2_a069_4cbd_8650_ef3ec2eccd14
is: SBO:0000252
initial amount: NaN
constant: false
name: ACOT8
has only substance units: false
boundary condition: true
is encoded by: hsa:10005
initial concentration: NaN
is: O14734
type: Species

metaR ME2m
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
fast: false
reversible: false
name: malic enzyme (NADP), mitochondrial
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.38
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.40

http://identifiers.org/biomodels.db/MODEL1310110051#_8b372f05_1daf_43b6_be04_803fae1ad34a
name: PIK3CG
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5294
is: SBO:0000252
boundary condition: true
is: P48736
initial concentration: NaN
type: Species

metaR S6T8g
reactant: MODEL1310110051#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110051#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_3a8dd68d_24c7_41bd_be7c_5da403f40dcb
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: Q96C36
name: PYCR2
type: Species
is encoded by: hsa:29920
boundary condition: true

metaR r1566
kinetic law: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110051#
reversible: true
product: MODEL1310110051#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110051#_d9f755fa_8c17_4a3b_b815_185a2cec0c80
constant: false
is encoded by: hsa:23530
is: Q13423
has only substance units: false
name: NNT
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaM uacgam c
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:57705
boundary condition: false
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial concentration: 1.0
type: Species

metaM Lpipecol x
has only substance units: false
name: L-pipecolic acid
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:30913
type: Species
initial amount: NaN
is: HMDB00716
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408

metaM octd11ecoa m
is: HMDB06294
type: Species
initial amount: NaN
boundary condition: false
name: 11-octadecenoylcoa
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false

metaM hexdectecoa m
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
name: 2,4,7,10-hexadecatetraenoylcoa
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

metaR r2116
kinetic law: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
modifier: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM Rtotal c
is: HMDB01448
type: Species
boundary condition: false
is: CHEBI:16189
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total

metaM btn c
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
is: CHEBI:3420
boundary condition: false
name: Biotin
is: SBO:0000247
is: HMDB00030
constant: false

metaR RE2625C
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE2625
is described by: ECO:0000000
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_83167935_5ce6_4400_be71_985790c51af6
is: Q9BV79
is: SBO:0000252
boundary condition: true
name: MECR
has only substance units: false
initial amount: NaN
is encoded by: hsa:51102
initial concentration: NaN
type: Species
constant: false

metaR r1560
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110051#
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_d3714f94_9159_474c_bcc2_e30b078e2e42
is encoded by: hsa:AI934540
constant: false
has only substance units: false
name: _AI934540_1_c
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM gdp g
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01201
initial amount: NaN
type: Species
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
name: GDP(3-)

metaM oagt3 hs g
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
name: 9-O-Acetylated GT3
is: HMDB00286
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58367
is: C00029
is: SBO:0000247
initial amount: NaN

metaR ALASERNaEx
is: SBO:0000185
is described by: ECO:0000269
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_3d37a6fa_ddc9_4834_96b7_8446763317c0
is: SBO:0000252
boundary condition: true
is: B2RDU6
constant: false
initial concentration: NaN
name: MVK
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:4598

metaR r2115
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000

metaR FAOXC1811602m
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: false
is: SBO:0000176
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction

metaR ILETA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
name: isoleucine transaminase
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#

metaM HC02208 e
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:27696
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
name: prostaglandin-d1

metaR NADS2
reactant: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: NAD synthase (glutamine-hydrolysing)
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.3.5.1

http://identifiers.org/biomodels.db/MODEL1310110051#_86527459_1450_402b_8095_ab288227f2ed
constant: false
initial concentration: NaN
is encoded by: hsa:27068
is: SBO:0000252
is: F8WDN9
initial amount: NaN
has only substance units: false
name: PPA2
type: Species
boundary condition: true

metaR r0822
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
is: SBO:0000185
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000

metaR DNDPt38m
kinetic law: MODEL1310110051#
is: SBO:0000185
fast: false
modifier: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110051#
reversible: false
type: Reaction
name: dUTP transport via dUDP antiport

metaR GHMT2rm
type: Reaction
name: glycine hydroxymethyltransferase, reversible, mitochondrial
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.1

http://identifiers.org/biomodels.db/MODEL1310110051#_62b5abc5_6f5a_4ff0_bd81_312915c9be81
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: MANBA
initial concentration: NaN
is encoded by: hsa:4126
is: O00462
type: Species
initial amount: NaN

metaM thyox L c
is: CHEBI:18332
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00248
is: SBO:0000247
boundary condition: false

metaM ksii core2 pre3 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: HMDB00175
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: keratan sulfate II biosynthesis, precursor 3
is: SBO:0000247
is: CHEBI:58053
is: C00130
type: Species
initial amount: NaN

metaR OAGT3te
product: MODEL1310110051#
name: oagt3 hs transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
fast: false
is: SBO:0000185
type: Reaction

metaM oagt3 hs c
is: HMDB00286
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58367
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
is: C00029
type: Species
constant: false
name: 9-O-Acetylated GT3

metaR r2118
is: SBO:0000185
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
product: MODEL1310110051#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110051#
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110051#_d8d714b1_ee95_476b_ad30_278db2ec7cbe
initial concentration: NaN
name: ST3GAL3
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR r1561
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110051#

metaR DNDPt22m
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269
name: dTDP transport via dUDP antiport
reversible: false
is: SBO:0000185

metaR SMS
is: SBO:0000176
product: MODEL1310110051#
name: Sphingomyelin synthase (homo sapiens)
reactant: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.27
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ

metaM ksi deg31 l
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 31
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
is: HMDB01354
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57455

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_b532ae06_f29b_4ca1_a938_0bf2a3b91961
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:1375
is: SBO:0000252
is: Q92523
has only substance units: false
initial concentration: NaN
name: CPT1B

metaR CRNtim
is: SBO:0000185
product: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000269
type: Reaction
name: L-carnitine transport out of mitochondria via diffusion

metaR H7ET2er
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
reversible: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
reactant: MODEL1310110051#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
product: MODEL1310110051#

metaM strdnccoa x
is: C16163
is: http://identifiers.org/pubchem.compound/47205473
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
constant: false
name: stearidonyl coenzyme A
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB06519

metaR HISSNAT5tc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR S6TASE11ly
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000

metaM oagt3 hs e
is: SBO:0000247
is: CHEBI:18421
initial amount: NaN
name: 9-O-Acetylated GT3
is: HMDB02168
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3

metaM arachdcoa m
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
has only substance units: false
is: HMDB06523
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_f90456a6_2370_4da6_b798_5e46b0a72aaf
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: NME1
is: SBO:0000252
is encoded by: hsa:4830
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_375fb154_f48f_4b2b_a3b7_5501c361f560
initial amount: NaN
is encoded by: hsa:W87865
is: SBO:0000252
boundary condition: true
constant: false
name: _W87865_1_c
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_b9e59b91_a0cf_4987_ab9b_4b61ddf8b908
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:10455
has only substance units: false
boundary condition: true
initial amount: NaN
name: ECI2
is: O75521
constant: false

metaR EX c16dc
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaR GMPtn
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: GMP nuclear transport
fast: false
type: Reaction
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_f4ecc7d6_d391_4f0f_91be_c5cc0b3ab555
is: O75489
is encoded by: hsa:4722
boundary condition: true
type: Species
is: SBO:0000252
name: NDUFS3
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r2117
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110051#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110051#

metaR r1562
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
kinetic law: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM HC00695 m
boundary condition: false
constant: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:17432
name: S-Succinyldihydrolipoamide
has only substance units: false
initial concentration: 1.0

metaM hexe3coa x
is: HMDB06522
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: 3-hexenoylcoa
constant: false
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM tetdec2coa c
initial concentration: 1.0
has only substance units: false
name: tetradecadienoylcoa
is: SBO:0000247
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02014
initial amount: NaN
type: Species
boundary condition: false

metaR FAOXC12DCTc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaR KHte
reactant: MODEL1310110051#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110051#
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110051#
name: KHte

http://identifiers.org/biomodels.db/MODEL1310110051#_126d65cf_a620_4bc7_b1b2_2f765d229821
name: ABTB2
is encoded by: hsa:25841
boundary condition: true
constant: false
is: E9PRW7
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_338b8359_a32a_4924_8e86_206d6907a288
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:122970
name: ACOT4
constant: false
is: Q8N9L9
boundary condition: true
is: SBO:0000252

metaM r5p c
is: SBO:0000247
initial amount: NaN
is: C00117
is: CHEBI:18189
constant: false
name: alpha-D-Ribose 5-phosphate
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00618
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117

metaM ksii core2 pre8 g
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: HMDB00175
is: C00130
type: Species
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

metaR OAGT3tg
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
name: oagt3 hs intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110051#_a23cf74e_f896_4a27_9dc2_5d15ab41366f
is: Q8TB61
initial amount: NaN
name: SLC35B2
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:347734
has only substance units: false
type: Species

metaM g3p c
initial concentration: 1.0
name: Glyceraldehyde 3-phosphate
is: CHEBI:58027
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
constant: false
is: http://identifiers.org/pubchem.compound/3930
is: HMDB01112
initial amount: NaN
is: C00661
type: Species

metaR C4CRNCPT2
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_7aa8b770_3dd6_47e9_b29b_8f7042ab943d
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC9A4
boundary condition: true
constant: false
is: Q6AI14
is encoded by: hsa:389015
initial concentration: NaN
type: Species

metaM gua e
boundary condition: false
constant: false
is: CHEBI:16235
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
name: guanine
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_9f82c8b6_a091_4a68_8185_a0bb217736c6
type: Species
constant: false
boundary condition: true
has part: P08195
is encoded by: hsa:6520
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:56301
has part: Q9NS82
name: SLC7A10:SLC3A2

metaM pan4p m
is: SBO:0000247
initial amount: NaN
name: pantetheine 4'-phosphate(2-)
is: CHEBI:47942
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
has only substance units: false
is: HMDB01416
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_580916b4_ad6a_4f2d_b70d_9d8ae46e21c7
name: SULT1A1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6817
constant: false
boundary condition: true
is: P50225
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_c3f6fb17_9bb4_4e23_9be5_36ab6606e4e7
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI697028
has only substance units: false
type: Species
name: _AI697028_1_e
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM thymd m
has only substance units: false
name: Thymidine
is: CHEBI:17748
is: HMDB00273
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
type: Species
initial concentration: 1.0
is: C00214

metaR GLNCYSNaEx
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
fast: false
product: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR ACACT10m
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
reversible: true
fast: false

metaM hx2coa m
name: trans-Hex-2-enoyl-CoA
has only substance units: false
is: C05998
constant: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
type: Species

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: Deoxycytidine
initial amount: NaN
boundary condition: false
is: CHEBI:15698
initial concentration: 1.0
is: SBO:0000247
is: HMDB00014
is: C00881
has only substance units: false
type: Species
constant: false

metaM leuktrD4 e
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB03080
type: Species
is: CHEBI:28666
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
name: Leukotriene D4
initial concentration: 1.0

metaM CE2705 n
initial amount: NaN
has only substance units: false
is: HMDB02281
initial concentration: 1.0
is: CHEBI:15374
name: quinonoid dihydrobiopterin
constant: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
type: Species

metaR HIStN1
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
is described by: ECO:0000269
name: Histidine transport (Na, H coupled)
kinetic law: MODEL1310110051#
is: SBO:0000185
type: Reaction
product: MODEL1310110051#

metaR GluForTx
product: MODEL1310110051#
fast: false
name: Glutamate formimidoyltransferase
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110051#_6d51801b_690f_4d23_ba3e_0fbc5807e2b5
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10588
name: MTHFS
is: SBO:0000252
constant: false
is: P49914
type: Species
initial concentration: NaN

metaM hexe3coa m
boundary condition: false
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
is: HMDB06522
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 3-hexenoylcoa

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_e33c9187_e66f_4032_8505_df1133c31e59
constant: false
is: SBO:0000252
type: Species
name: COX2
initial concentration: NaN
is: Q7GXZ8
is encoded by: hsa:4513
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r0821
reversible: true
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_7414ca90_47b6_4a72_98ca_cc8ecb556c7b
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:R39999
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _R39999_1_c

metaR MGCHrm
kinetic law: MODEL1310110051#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
reversible: true
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaR RE2987X
fast: false
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reversible: true
name: RE2987
reactant: MODEL1310110051#
modifier: MODEL1310110051#

metaR S6TASE14ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000176

metaM 4mlacac c
type: Species
is: SBO:0000247
boundary condition: false
name: 4-maleylacetoacetate
initial amount: NaN
is: CHEBI:17105
constant: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
initial concentration: 1.0
is: HMDB02052
has only substance units: false

metaR HPDCACRNCPT1
fast: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
name: carnitine fatty-acyl transferase
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
type: Reaction
product: MODEL1310110051#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_b5b75a36_7e17_454c_be67_a1a1a6b72d03
is encoded by: hsa:1345
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: COX6C
type: Species
is: SBO:0000252
is: P09669

metaR MMMm
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.99.2
reactant: MODEL1310110051#
product: MODEL1310110051#
is: SBO:0000176
name: methylmalonyl-CoA mutase
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
reversible: true

metaM gua c
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
constant: false
is: CHEBI:16235
is: C00242
initial amount: NaN
type: Species
has only substance units: false
name: Guanine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00132
boundary condition: false

metaM crn x
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16347
has only substance units: false
is: C00318
initial concentration: 1.0
is: HMDB00062
boundary condition: false
name: L-Carnitine

metaM m2gacpail hs r
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_28cf658b_4f15_4f65_b0fd_2a40f4ed8962
name: NDUFA5
is encoded by: hsa:4698
initial amount: NaN
is: Q16718
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM cspg b e
is: HMDB00300
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial amount: NaN
boundary condition: false
is: CHEBI:17568
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: SBO:0000247
is: C00106

metaM leuktrD4 c
boundary condition: false
is: SBO:0000247
is: HMDB03080
type: Species
constant: false
is: CHEBI:28666
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN
name: Leukotriene D4
has only substance units: false
initial concentration: 1.0

metaR CYSTHRNaEx
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
modifier: MODEL1310110051#
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_72e095d1_73ff_47c0_ace1_c147a2d5f2c8
constant: false
type: Species
is encoded by: hsa:6713
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SQLE
initial concentration: NaN
boundary condition: true
is: Q5HYI4

http://identifiers.org/biomodels.db/MODEL1310110051#_5d8cac63_d00a_485a_8e66_d3e57c1bf8ab
constant: false
name: PIGP
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51227
is: P57054
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_0c43c76f_66e6_463c_bae6_60b3992fbabd
constant: false
name: NME6
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10201
type: Species
boundary condition: true
initial concentration: NaN
is: O75414

metaR RE3009C
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
name: RE3009
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: false
fast: false

metaM ksii core2 deg3 l
is: HMDB00143
initial amount: NaN
has only substance units: false
is: CHEBI:12936
constant: false
is: SBO:0000247
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
initial concentration: 1.0
boundary condition: false
type: Species
name: keratan sulfate II (core 2-linked), degradation product 3

metaR HPDCACRNt
name: heptadecanoate transport into the mitochondria
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
type: Reaction
modifier: MODEL1310110051#
fast: false
is described by: ECO:0000269
product: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_211b20db_8edc_4dd0_879b_38af946151a1
type: Species
is: Q06136
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2531
constant: false
has only substance units: false
is: SBO:0000252
name: KDSR

metaR r1567
fast: false
reversible: true
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM CE4791 x
is: CHEBI:57923
type: Species
name: 3(S)-hydroxy-dihomo-gama-linolenoyl-CoA
notes: FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-30,34-36,40,49,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t29-,30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4791
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR CORE2GTg
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
modifier: MODEL1310110051#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
reversible: false
type: Reaction
fast: false

metaM digalside hs l
is: C06126
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide
is: http://identifiers.org/pubchem.compound/8383
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaM gdp n
is: CHEBI:58189
has only substance units: false
constant: false
name: GDP(3-)
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
boundary condition: false

metaM rbt e
boundary condition: false
is: HMDB00508
initial amount: NaN
is: CHEBI:15963
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_a7d97376_9fde_4437_9170_1235b566445a
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: DCK
is: P27707
is encoded by: hsa:1633
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_183342b0_a482_41e6_8f9d_7d4b929b6a0d
has only substance units: false
constant: false
is encoded by: hsa:55229
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9NVE7
name: PANK4

metaR GALt4
name: galactose transport via sodium symport
kinetic law: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
product: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_d858c0b4_0dd6_4898_b186_73f6c0ac45fd
type: Species
constant: false
is encoded by: hsa:83594
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: NUDT12
is: Q9BQG2

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR GLUTCOADHm
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.7
reversible: false
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000304
name: glutaryl-CoA dehydrogenase (mitochondria)
type: Reaction
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
is: SBO:0000176

metaR HPDCACRNCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110051#
fast: false
name: heptadecanoate transport into the mitochondria
type: Reaction
modifier: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#

metaR CYOOm3
is version of: http://identifiers.org/ec-code/1.9.3.1
name: cytochrome c oxidase, mitochondrial Complex IV
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
reversible: false
fast: false

metaR r1568
kinetic law: MODEL1310110051#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110051#
type: Reaction
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

metaM octd11ecoa c
constant: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 11-octadecenoylcoa
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110051#_c8f3280b_1dd1_462d_804e_017c79f5de7a
has only substance units: false
is encoded by: hsa:3420
constant: false
type: Species
initial amount: NaN
name: IDH3B
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_2a4c39bc_9fcd_44bc_8256_09f40111be89
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: P51648
is encoded by: hsa:224
constant: false
is: SBO:0000252
name: ALDH3A2
type: Species

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR r1569
reactant: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#

metaR GALSIDEtg
is: SBO:0000185
name: galactocerebroside intracellular transport
reversible: true
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
kinetic law: MODEL1310110051#
fast: false
is described by: ECO:0000000

metaR RE2814R
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
name: RE2814
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_1f7c7bb8_8095_49cf_872d_f811cfb41202
name: SLC23A2
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:9962
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_18b02ecc_563f_4613_8a95_e014bff1c7da
is encoded by: hsa:79053
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: A6NDW6
has only substance units: false
constant: false
boundary condition: true
name: ALG8

http://identifiers.org/biomodels.db/MODEL1310110051#_b2761a9a_5e08_49c7_9974_3d34ca1ec0eb
boundary condition: true
initial concentration: NaN
is: P28329
is: SBO:0000252
constant: false
name: CHAT
initial amount: NaN
type: Species
is encoded by: hsa:1103
has only substance units: false

metaR ADRNCRNt
type: Reaction
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_76a61b9f_bc90_4eec_b484_54f4e3702796
has only substance units: false
boundary condition: true
is encoded by: hsa:206358
constant: false
initial amount: NaN
name: SLC36A1
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q1LZ56

metaR FAOXC185C164m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR AG13T3g
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110051#

metaR HACD1m
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
fast: false
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000134
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_61ec64be_b5c1_4baf_b1fa_e71e3703f2c0
name: SLC12A4
boundary condition: true
is encoded by: hsa:6560
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: F5H066

http://identifiers.org/biomodels.db/MODEL1310110051#_c0eab619_f3e5_40ef_a0e6_696caefae3fa
initial amount: NaN
has only substance units: false
is: D3DX95
type: Species
initial concentration: NaN
is encoded by: hsa:1103
constant: false
name: CHAT
boundary condition: true
is: SBO:0000252

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_ac22b4ad_56b2_4527_a21f_efccc590620a
name: ZADH2
constant: false
has only substance units: false
boundary condition: true
is: Q8N4Q0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:284273
type: Species

metaR C4STMO1r
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.72
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#

metaM hedepecoa m
is: HMDB02288
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 2,4,7,10,13-hexadecapentenoylcoa
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
type: Species

metaM pan4p e
is: SBO:0000247
type: Species
boundary condition: false
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2
constant: false
is: HMDB01416
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:47942
name: Pantetheine 4'-phosphate

metaM hexdectecoa x
is: SBO:0000247
name: 2,4,7,10-hexadecatetraenoylcoa
is: HMDB02288
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM fru c
boundary condition: false
constant: false
has only substance units: false
is: C00095
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
type: Species
is: SBO:0000247
is: CHEBI:15824
name: D-Fructose
initial amount: NaN
initial concentration: 1.0

metaR RE1810M
product: MODEL1310110051#
is described by: ECO:0000000
fast: false
name: RE1810
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
is: SBO:0000176
reactant: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_1a079f02_99f0_443f_88b4_d1e8ae5dad89
initial concentration: NaN
name: PEMT
is encoded by: hsa:10400
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR PTPAT
is: SBO:0000176
type: Reaction
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.7.3
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
fast: false
reversible: true
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_b8ab93f2_6ea8_4043_8918_98dba87976c1
name: AHCYL1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:10768
type: Species
constant: false

metaM 3hexdtetcoa x
boundary condition: false
is: HMDB02288
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

metaM fru e
constant: false
name: D-Fructose
initial amount: NaN
is: C00095
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00660
has only substance units: false
is: CHEBI:15824
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095

metaR P4507A1r
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110051#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.14.13.17
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110051#

metaR C12OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaM HC01376 m
is: CHEBI:28692
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: S-(2-Methylbutanoyl)-dihydrolipoamide
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118

metaM core2 g
name: Core 2
type: Species
is: CHEBI:15876
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaR DGTPtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: dGTP diffusion in nucleus
fast: false
reactant: MODEL1310110051#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR CHOLtr
is: SBO:0000185
product: MODEL1310110051#
name: choline intracellular transport
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false

metaM tetpent6 e
is: SBO:0000247
has only substance units: false
is: HMDB06322
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
initial amount: NaN
name: tetracosapentaenoic acid, n-6

metaR ADPCOAPTE
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR NADHtpu
fast: false
name: NADH transporter, peroxisome
product: MODEL1310110051#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_ac56132a_3b1f_4ce0_a257_fd0692957113
boundary condition: true
is: Q9Y259
initial concentration: NaN
type: Species
constant: false
name: CHKB
initial amount: NaN
is encoded by: hsa:1120
is: SBO:0000252
has only substance units: false

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM ksi pre36 g
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 36
boundary condition: false
type: Species
constant: false

metaM malt e
name: Maltose
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: HMDB00163
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:17306
is: C00208
has only substance units: false
initial concentration: 1.0
type: Species

metaR NACHEXA21ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110051#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: false

metaR PPCOAOm
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is described by: ECO:0000269
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR GCALDD
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
kinetic law: MODEL1310110051#
name: Glycolaldehyde dehydrogenase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110051#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110051#
is: SBO:0000176

metaR RTOTAL2FATPc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM HC02216 e
type: Species
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:28922
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_7e9548d7_fbfc_44fd_889d_fe67cc4922e7
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: A8K761
is encoded by: hsa:4716
name: NDUFB10
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_1965af91_48e6_449b_9a5c_36fbc3322d3c
constant: false
is: SBO:0000252
is: Q8TF08
boundary condition: true
has only substance units: false
name: COX7B2
is encoded by: hsa:170712
type: Species
initial amount: NaN
initial concentration: NaN

metaR LEUt5m
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110051#
name: leucine mitochondrial transport
is described by: ECO:0000000

metaR CHOLtu
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
name: Choline uniport
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110051#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110051#

metaM ksi pre34 g
name: keratan sulfate I biosynthesis, precursor 34
is: C00130
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
initial concentration: 1.0
boundary condition: false
is: HMDB00175
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_5386f01c_5230_46b6_af1c_143fac4a1832
name: GALNT9
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9HCQ5
initial amount: NaN
type: Species
is encoded by: hsa:50614

metaM etoh c
is: HMDB00108
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: ethanol
is: CHEBI:16236
boundary condition: false

metaR AKGtp
name: AKG transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
kinetic law: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
reversible: true
fast: false
reactant: MODEL1310110051#
type: Reaction

metaM CE0233 c
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01993
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
constant: false
is: CHEBI:17899
name: 5beta-cholestane-3alpha,7alpha,27-triol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110051#_5e33cca7_75e8_4592_93f1_df62ff4f8faa
type: Species
is: Q96E98
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:6005
name: RHAG
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_70f2adab_b210_49ea_b70c_d0569d16fed5
initial amount: NaN
name: SLCO1B1
constant: false
is encoded by: hsa:10599
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: Q9Y6L6
has only substance units: false

metaM tetpent6 c
initial amount: NaN
boundary condition: false
is: HMDB06322
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: tetracosapentaenoic acid, n-6
has only substance units: false
constant: false

metaR UMPK
reversible: true
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
modifier: MODEL1310110051#
name: UMP kinase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#

metaM lneldccrn m
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
is: HMDB06461
constant: false
has only substance units: false
name: Linoelaidyl carnitine
initial concentration: 1.0

metaR RE1254C
name: RE1254
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is described by: ECO:0000000
reversible: true
fast: false

metaR r0603
modifier: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.12
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12

metaM arachdcoa x
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB06523
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57368
name: arachidonoyl-CoA(4-)

metaR 4ABUTtcn
reversible: false
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
name: transport of GABA
is described by: ECO:0000134
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
kinetic law: MODEL1310110051#

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR CITRtm
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: citrulline mitochondrial transport via proton antiport
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000185

metaM HC02216 c
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: CHEBI:28922
name: prostaglandin-f2beta
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN

metaR P4501B1r
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
name: cytochrome P450 1B1
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.14.14.1
type: Reaction

metaM glc D l
initial concentration: 1.0
has only substance units: false
is: CHEBI:4167
boundary condition: false
is: HMDB00122
initial amount: NaN
type: Species
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
is: SBO:0000247

metaR r2001
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110051#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
kinetic law: MODEL1310110051#
fast: false
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_5b3fc6fe_6c5e_4576_b114_e990d0f639bc
is: SBO:0000252
is: Q9Y5P4
name: COL4A3BP
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:10087
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_79eeddf1_878c_4876_be0a_9236358f93bb
boundary condition: true
has only substance units: false
is: P07195
initial amount: NaN
initial concentration: NaN
type: Species
name: LDHB
is: SBO:0000252
is encoded by: hsa:3945
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_d279b0f7_e21a_451e_8966_300b3b3bfb28
name: NDUFB6
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4712
is: O95139

metaM etoh e
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:16236
has only substance units: false
name: ethanol
initial concentration: 1.0
is: HMDB00108
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469

metaM dd3coa x
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 3-dodecenoylcoa
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
is: HMDB04257

metaM Rtotal2coa c
is: CHEBI:60377
has only substance units: false
is: C00055
type: Species
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00095
initial amount: NaN
constant: false
name: R total 2 coenzyme A

metaR RE1522M
type: Reaction
fast: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110051#
name: RE1522
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaR RE2651R
fast: false
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2651
product: MODEL1310110051#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110051#

metaR PSt3
reactant: MODEL1310110051#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: phosphatidylserine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaM odecoa x
initial amount: NaN
type: Species
is: CHEBI:57387
constant: false
has only substance units: false
name: oleoyl-CoA(4-)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01322

metaR CHOLtn
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
name: Choline transport, nuclear through pores
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
product: MODEL1310110051#

metaM L2aadp c
is: CHEBI:58672
initial amount: NaN
is: HMDB00510
initial concentration: 1.0
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: L-2-aminoadipate(1-)

metaM estradiol r
has only substance units: false
type: Species
is: HMDB00151
name: estradiol
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:16469
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial concentration: 1.0

metaM uacgam r
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00290

metaR r1443
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
reversible: false
kinetic law: MODEL1310110051#
name: EC:1.3.3.6
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

metaR RE2814M
type: Reaction
name: RE2814
product: MODEL1310110051#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000000

metaR SBTR
fast: false
name: D-sorbitol reductase
modifier: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21

metaR C10CRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_56f747b0_01d8_4511_8b93_9839e0b88689
boundary condition: true
has only substance units: false
name: PDE9A
is encoded by: hsa:5152
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_988d805e_9cd6_442d_8863_3ee5b6f1a401
constant: false
name: PRDX3
initial concentration: NaN
boundary condition: true
is: P30048
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10935
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_2c48e3a2_1cc9_4c95_8842_e4142f06e063
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is: G0W2N5
boundary condition: true
name: SLC14A1
initial concentration: NaN
is encoded by: hsa:6563
initial amount: NaN

metaR RE2988X
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110051#
is: SBO:0000176
name: RE2988
kinetic law: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction

metaR PDE4
reactant: MODEL1310110051#
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.4.35
is: SBO:0000176
reversible: false
type: Reaction
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
fast: false
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.4.17

metaR PIACGT
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.83
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.198
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol N-acetylglucosaminyltransferase
modifier: MODEL1310110051#

metaM 3hdcoa m
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
constant: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
name: (S)-3-Hydroxydecanoyl-CoA
is: SBO:0000247

metaM CE2705 c
initial concentration: 1.0
constant: false
boundary condition: false
name: quinonoid dihydrobiopterin
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
type: Species
is: SBO:0000247
is: CHEBI:36781
initial amount: NaN

metaM cs e deg1 l
initial concentration: 1.0
is: HMDB00868
boundary condition: false
is: CHEBI:57737
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
constant: false
type: Species

metaR NDPK10
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110051#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110051#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_7b6b6e48_7b21_4ae7_bc5f_d9fe55412fc6
initial concentration: NaN
is encoded by: hsa:5831
constant: false
is: A6NFM2
is: SBO:0000252
type: Species
name: PYCR1
has only substance units: false
initial amount: NaN
boundary condition: true

metaR FADH2tx
kinetic law: MODEL1310110051#
fast: false
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: FADH2 transporter, peroxisomal
reactant: MODEL1310110051#
reversible: true

metaR IZPN
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: Imidazolonepropionase
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110051#

metaR 5ADTSTSTERONESULT
reversible: false
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
modifier: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.14
is: SBO:0000176
name: 5alpha-Dihydrotestosterone sulfotransferase

metaM digalside hs c
is: http://identifiers.org/pubchem.compound/8383
boundary condition: false
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
is: C06126
type: Species
name: Digalactosylceramide
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_9dddcae0_5228_42f3_9941_adc539d66c8b
is: Q05C14
is: SBO:0000252
name: FOLR3
initial amount: NaN
is encoded by: hsa:2352
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaR r1051
type: Reaction
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
is: SBO:0000185
fast: false
name: Vesicular transport
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is described by: ECO:0000000

metaR ADNt
product: MODEL1310110051#
reversible: true
fast: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000269
name: adenosine facilated transport in cytosol
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_ed13bfa6_da18_4c51_ad5c_bcf233dede33
is: SBO:0000252
is: Q9HBU6
boundary condition: true
name: ETNK1
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:55500
initial concentration: NaN

metaR FAS120COA
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
fast: false
product: MODEL1310110051#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110051#
type: Reaction
name: fatty-acyl-CoA synthase (n-C12:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
reactant: MODEL1310110051#
modifier: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_13375be0_b524_417e_9ac0_d80276d55154
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
name: PRDX3
initial amount: NaN
is: E9PH29
is encoded by: hsa:10935

metaM ksii core2 deg6 l
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 6
notes: FORMULA: C44H72N4O33SX CHARGE: -1
type: Species
has only substance units: false
constant: false

metaM C05279 m
is: CHEBI:28387
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: trans,cis-Lauro-2,6-dienoyl-CoA
has only substance units: false
is: HMDB11123
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
constant: false

metaR r1445
reversible: false
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000000
name: EC:1.3.3.6
is: SBO:0000176
type: Reaction

metaR PIt8
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter
type: Reaction
product: MODEL1310110051#
is: SBO:0000185
fast: false
is described by: ECO:0000006

metaM didp c
initial concentration: 1.0
initial amount: NaN
constant: false
name: dIDP
is: CHEBI:28823
is: HMDB03536
type: Species
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r1050
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000000
name: Vesicular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_8f3d445d_7767_46cd_b0c9_f55fa2463ba8
has only substance units: false
type: Species
name: STS
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:412
boundary condition: true
is: P08842
constant: false
initial concentration: NaN

metaM ksi pre4 g
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 4
initial concentration: 1.0
type: Species
notes: FORMULA: C101H165N7O72X CHARGE: -1
is: CHEBI:58053
is: HMDB00175
initial amount: NaN
is: C00130

metaM dopa e
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:59905
name: dopaminium(1+)
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
is: SBO:0000247

metaR PDE1
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.17
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110051#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.35
reversible: false
product: MODEL1310110051#

metaM xol7ah2al m
constant: false
initial concentration: 1.0
is: HMDB06894
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:27428

MODEL1310110051#
species: metaM c81crn e
species: metaM cspg e e
species: metaM c101crn e
species: metaM tag hs c
species: metaM tettet6coa x
species: metaM apoC Lys btn c
species: metaM ksi pre27 g
species: metaM estrone c
species: metaM accoa m
species: metaM sph1p c
species: metaM 3mob m
species: metaM q10 m
species: metaM glyb m
species: metaM sebcoa c
species: metaM dodecanac c
species: metaM ksii core4 pre5 g
species: metaM prostge1 c
species: metaM nadp r
species: metaM ksi e
species: metaM ala L m
name: PIK3CA:PIK3R3
stoichiometry: 7.0
species: metaM 3deccrn c
species: metaM ksii core4 pre2 g
species: metaM cs e deg5 l
species: metaM CE5118 m
species: metaM dopa e
species: metaM 3odcoa m
species: metaM dcacoa x
species: metaM mescoa m
species: metaM ksi pre17 g
species: metaM pe hs m
species: metaM ksi deg23 l
initial concentration: NaN
species: metaM cytd m
species: metaM o2 x
species: metaM dcyt n
species: metaM 44mctr r
species: metaM duri e
species: metaM docoscoa x
species: metaM leuktrA4 c
species: metaM glyb e
species: metaM CE4872 c
species: metaM uri e
species: metaM 4hexdtricoa x
species: metaM mal L e
species: metaM galgluside hs g
species: metaM gpi prot hs r
species: metaM accoa x
species: metaM thbpt c
species: metaM dmhptcrn m
species: metaM 4nphsf c
species: metaM ctp n
species: metaM Ser Thr g
species: metaM ach c
species: metaM 2mop m
stoichiometry: 1.0
species: metaM ksii core2 pre7 g
species: metaM pyr e
species: metaM Rtotal3 e
species: metaM 3php c
species: metaM ha l
species: metaM phe L e
species: metaM acmanap c
species: metaM ocdcea e
species: metaM ksi deg24 l
species: metaM leuktrE4 c
species: metaM itp e
species: metaM tddedicoa m
species: metaM vacc c
species: metaM andrstandn r
species: metaM akg c
species: metaM lpro m
species: metaM ddcacoa c
species: metaM sphmyln hs c
species: metaM trdrd m
species: metaM biocyt c
species: metaM 2mb2coa c
species: metaM fn2m2masn g
species: metaM tetpent3coa c

http://identifiers.org/biomodels.db/MODEL1310110051#_5a60d726_8fb5_408b_aba0_d46829b862e9
initial concentration: NaN
type: Species
is: F8W1L5
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: GPD1
is encoded by: hsa:2819

metaM 2hexdtricoa x
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02288
name: 2,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false

metaR ACETONEt2m
modifier: MODEL1310110051#
product: MODEL1310110051#
name: acetone mitochondrial transport via proton symport
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR FAOXC181C161m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaM dhlpro m
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Dihydrolipolprotein
has only substance units: false
boundary condition: false
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
is: CHEBI:16194
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_44c209eb_1798_407f_b882_242769beffc1
boundary condition: true
name: HGD
is: Q93099
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:3081
initial amount: NaN
is: SBO:0000252

metaR r1444
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
fast: false
is described by: ECO:0000000
name: EC:1.3.3.6

metaR PI345P3P
modifier: MODEL1310110051#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
reversible: false
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
kinetic law: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.67
reactant: MODEL1310110051#

metaR PIt7
is: SBO:0000185
kinetic law: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
product: MODEL1310110051#
name: phosphate transport in/out via three Na+ symporter
type: Reaction
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT

metaM hxan c
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00157
is: CHEBI:17368
is: SBO:0000247
name: Hypoxanthine
boundary condition: false
type: Species
is: C00262
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR r2111
is described by: ECO:0000000
product: MODEL1310110051#
type: Reaction
kinetic law: MODEL1310110051#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
fast: false
is: SBO:0000185
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM ksi deg9 l
name: keratan sulfate I, degradation product 9
is: HMDB00143
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:12936

metaM pro L c
name: L-proline
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
boundary condition: false
constant: false
is: HMDB00162

metaM pglyc hs e
has only substance units: false
is: SBO:0000247
name: phosphatidylglycerol(1-)
is: CHEBI:60523
constant: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR FAOXTC102C101m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaM 2hexdtricoa m
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110051#_44ad2a83_a508_4026_9905_4eb4b3eab183
has only substance units: false
initial concentration: NaN
is: Q8NCG5
is encoded by: hsa:10164
initial amount: NaN
boundary condition: true
name: CHST4
is: SBO:0000252
type: Species
constant: false

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR r1446
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reversible: false
kinetic law: MODEL1310110051#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110051#
name: EC:1.3.3.6
fast: false
product: MODEL1310110051#

metaR FAOXC225C226x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR r2112
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true

metaR C181OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaM dopa c
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:59905
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
is: HMDB00073
has only substance units: false

metaR GNDer
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
reversible: false
product: MODEL1310110051#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110051#

metaM glc D r
is: HMDB00122
initial concentration: 1.0
is: CHEBI:4167
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
name: D-glucose

metaM uacgam g
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
is: SBO:0000247
is: CHEBI:57705
boundary condition: false

metaM thyox L e
is: SBO:0000247
name: L-thyroxine
is: CHEBI:18332
type: Species
initial concentration: 1.0
is: HMDB00248
boundary condition: false
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_4d6b0c70_54d9_4cb5_a7b1_f57fd4893a70
name: PIK3R1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5295
constant: false
has only substance units: false
initial amount: NaN
is: P27986
boundary condition: true
type: Species

metaR r0281
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
fast: false
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
product: MODEL1310110051#
reversible: true
is: SBO:0000176
modifier: MODEL1310110051#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
type: Reaction

metaR 3MOPte
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
name: Transport of 3-methyl-2-oxopentanoate
type: Reaction
reversible: true
is described by: ECO:0000134

metaM xol7ah2al c
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: CHEBI:27428
type: Species
initial amount: NaN

metaM 13dpg c
initial concentration: 1.0
is: HMDB01270
is: C00236
name: 3-Phospho-D-glyceroyl phosphate
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: http://identifiers.org/pubchem.compound/3535
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57604
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_824d398d_7e48_4b12_87c1_9aaf342c3c0c
initial amount: NaN
type: Species
is: Q96BD0
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:28231
constant: false
name: SLCO4A1
has only substance units: false

metaM r5p r
constant: false
name: alpha-D-Ribose 5-phosphate
type: Species
initial amount: NaN
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18189

metaM pro L e
type: Species
initial amount: NaN
name: L-proline
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17203
constant: false
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162

metaR GALASE10ly
name: beta-galactosidase, lysosomal
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110051#

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaR r2113
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110051#
reversible: true
product: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#

metaR SUCCTD
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM pglyc hs c
boundary condition: false
constant: false
name: phosphatidylglycerol(1-)
is: CHEBI:60523
has only substance units: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR G14T15g
reactant: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
modifier: MODEL1310110051#
type: Reaction

metaR SERALANaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110051#
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_d4550efe_b356_4159_89a8_79f745db3498
type: Species
is: Q9NXB9
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: ELOVL2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54898

metaR NACHEX2ly
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110051#

metaR DITPtn
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dITP nuclear transport
reactant: MODEL1310110051#
type: Reaction
fast: false
product: MODEL1310110051#
is described by: ECO:0000000
reversible: true

metaR FBP
name: fructose-bisphosphatase
is version of: http://identifiers.org/ec-code/3.1.3.11
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
fast: false
product: MODEL1310110051#
type: Reaction
reversible: false
modifier: MODEL1310110051#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP

metaR r2114
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_d0d6ff02_5153_4972_a843_1a18da37f5c0
boundary condition: true
is: Q9H0I9
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84076
is: SBO:0000252
name: TKTL2
type: Species
constant: false
initial amount: NaN

metaM lpam m
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: CHEBI:17460
is: HMDB00962
initial concentration: 1.0
name: lipoamide
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_0b28c547_0c77_49ec_ab80_6892086cf2dc
is: SBO:0000252
type: Species
is: Q53H96
has only substance units: false
is encoded by: hsa:65263
initial concentration: NaN
initial amount: NaN
name: PYCRL
boundary condition: true
constant: false

metaM for r
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: Formate
is: HMDB00142
is: SBO:0000247
is: CHEBI:15740
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: C00058
initial amount: NaN

metaR RE2625M
reactant: MODEL1310110051#
type: Reaction
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: true
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110051#
name: RE2625

metaM damp c
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00905
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
name: dAMP(2-)
constant: false
initial amount: NaN

metaR HEXDCRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaR ITCOAL1m
fast: false
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (GDP-forming), mitochondrial

metaR UMPK5n
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
type: Reaction
name: UMP kinase (dATP),nuclear
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR CITtam
type: Reaction
product: MODEL1310110051#
is: SBO:0000185
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reversible: true
name: citrate transport, mitochondrial
modifier: MODEL1310110051#

metaR r0604
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
fast: false
product: MODEL1310110051#
reversible: false
is described by: ECO:0000000
type: Reaction
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reactant: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#

metaM arachdcrn c
type: Species
is: HMDB01322
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
has only substance units: false
is: CHEBI:57387
name: C20:4 carnitine

metaM lald D c
name: (R)-lactaldehyde
is: HMDB06458
type: Species
initial amount: NaN
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
constant: false
boundary condition: false
is: CHEBI:17167
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM CE2432 m
boundary condition: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57795

metaM f26bp c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
initial concentration: 1.0
boundary condition: false
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
constant: false
type: Species
initial amount: NaN
is: HMDB01047
is: SBO:0000247
is: CHEBI:58579
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_477f7903_1cb0_4fa9_a581_c663f31363f6
initial concentration: NaN
is: SBO:0000252
is: Q9P1E4
boundary condition: true
is encoded by: hsa:4122
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: MAN2A2

http://identifiers.org/biomodels.db/MODEL1310110051#_6eb98ec6_d7d3_45eb_ba3d_aff4e4f4bba5
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:5151
is: SBO:0000252
initial concentration: NaN
name: PDE8A

metaM pail5p hs n
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
boundary condition: false
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR ACOAD10m
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is described by: ECO:0000269
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
type: Reaction
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
is: SBO:0000176

metaM didp n
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: dIDP
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: CHEBI:28823
has only substance units: false
is: HMDB03536

metaR PRISTCOAtcx
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR CHOLtg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
name: choline intracellular transport
kinetic law: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_43d3d9bf_b2e7_49b2_bc00_b31464511bcf
name: PIGX:PIGM
has part: Q9H3S5
initial amount: NaN
is encoded by: hsa:54965
constant: false
is: SBO:0000297
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:93183
has part: Q8TBF5
boundary condition: true

metaM hs deg7 l
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01352
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:17180
name: heparan sulfate, degradation product 7
type: Species
notes: FORMULA: C67H99N4O80S8 CHARGE: -9

metaM his L m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
boundary condition: false
constant: false
is: HMDB00177
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b07a986a_1abb_4002_8bac_d60faa6b0d5e
is: P05164
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4353
constant: false
initial amount: NaN
name: MPO
has only substance units: false

metaM lnlncacoa c
is: CHEBI:51985
type: Species
is: HMDB06290
has only substance units: false
boundary condition: false
name: alpha-Linolenoyl-CoA
initial concentration: 1.0
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_53ebd6dd_6eb1_49df_a5df_d9c480aedc1b
initial amount: NaN
boundary condition: true
is: O14495
type: Species
is: SBO:0000252
name: PPAP2B
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:8613

metaM xoldioloneh c
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:2288
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
is: HMDB06887
has only substance units: false
is: SBO:0000247
type: Species

metaM odecoa m
is: HMDB01322
has only substance units: false
initial amount: NaN
is: CHEBI:57387
type: Species
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
constant: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
boundary condition: false

metaM 3hexdtetcoa m
type: Species
initial amount: NaN
constant: false
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
name: 3,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110051#_08d2d035_8f6a_4967_bbb5_552c3141f7ec
is encoded by: hsa:51703
name: ACSL5
initial concentration: NaN
is: SBO:0000252
is: Q9ULC5
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM l2fn2m2masn g
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
constant: false
is: CHEBI:28067
has only substance units: false
notes: FORMULA: C68H113N4O49X CHARGE: 0
boundary condition: false

metaR RE2269E
reversible: true
is described by: ECO:0000000
fast: false
name: RE2269
reactant: MODEL1310110051#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is version of: http://identifiers.org/ec-code/3.4.21.39
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_7b60ee0b_5b59_45e9_9c14_c4c02af09ee6
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:221
type: Species
is: P43353
initial concentration: NaN
name: ALDH3B1
has only substance units: false
is: SBO:0000252

metaR r0287
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: false

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110051#
type: Reaction
reversible: false
modifier: MODEL1310110051#
reactant: MODEL1310110051#

metaR HSAT4ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
reactant: MODEL1310110051#
reversible: false
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

http://identifiers.org/biomodels.db/MODEL1310110051#_7b47eb95_ca60_47c9_9e95_72ddcf7ddde0
is encoded by: hsa:5151
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: PDE8A
constant: false
initial amount: NaN

metaR r2110
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110051#
type: Reaction

metaM occoa c
is: SBO:0000247
constant: false
type: Species
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
is: CHEBI:57386
initial concentration: 1.0
is: HMDB01070
boundary condition: false

metaM 4hexdtricoa x
initial amount: NaN
boundary condition: false
type: Species
name: 4,7,10-hexadecatrienoylcoa
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB02288

metaR HIVCACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaM 3ivcrn c
notes: FORMULA: C12H23NO5 CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/11966188
initial concentration: 1.0
name: 3-hydroxy-isovaleryl carnitine
is: C05998
has only substance units: false
is: HMDB06870

metaR r0813
is: SBO:0000185
reactant: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110051#
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:

metaR r1597
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
type: Reaction
product: MODEL1310110051#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

metaR DAG HSter
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: diacylglycerol ER export
kinetic law: MODEL1310110051#
reversible: false
fast: false
type: Reaction

metaM 3dodtricoa x
boundary condition: false
is: HMDB11123
name: 3,6,9-dodecatrienoylcoa
has only substance units: false
initial amount: NaN
is: C05279
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM dhea r
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: HMDB00077
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: 3beta-hydroxyandrost-5-en-17-one
is: CHEBI:28689
boundary condition: false

metaR S6TASE17ly
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
is: SBO:0000176
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110051#

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_57d7bbce_18a4_48c5_bee6_365f3c8b2112
boundary condition: true
name: COX4I2
is: Q96KJ9
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84701
type: Species
has only substance units: false
constant: false

metaM galside hs c
is: CHEBI:12947
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false

metaM HC00900 c
constant: false
is: CHEBI:30860
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
has only substance units: false
name: Methylmalonate
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_3d363710_bd40_4d0e_8884_d8c47ac6c4f5
type: Species
has only substance units: false
initial amount: NaN
is: Q6IBA0
is: SBO:0000252
constant: false
is encoded by: hsa:4725
initial concentration: NaN
boundary condition: true
name: NDUFS5

metaR GASNASE2ly
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: false
is described by: ECO:0000000
type: Reaction
name: glycosylasparaginase, lysosomal

metaM ddcacoa m
is: SBO:0000247
is: CHEBI:57375
has only substance units: false
is: C01832
initial concentration: 1.0
constant: false
initial amount: NaN
name: Dodecanoyl-CoA (n-C12:0CoA)
type: Species
boundary condition: false
is: HMDB03571
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832

http://identifiers.org/biomodels.db/MODEL1310110051#_ff93a4f7_0ecc_4177_aed0_8eddaaf51135
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:57665
is: SBO:0000252
name: RDH14
is: Q9HBH5

metaR r0812
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
reactant: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR RE2666C
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
type: Reaction
name: RE2666
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:

metaM HC02202 c
has only substance units: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
initial amount: NaN
is: CHEBI:57398
constant: false
name: prostaglandin A1(1-)
is: SBO:0000247
initial concentration: 1.0

metaM leuktrF4 e
name: leukotriene F4
boundary condition: false
initial amount: NaN
type: Species
is: HMDB06465
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:27491

metaR r1598
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: true
product: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110051#

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaR C162OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR r2129
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
reversible: true
is: SBO:0000185
reactant: MODEL1310110051#
type: Reaction

metaM acgagbside hs g
name: alpha GalNAc globoside
has only substance units: false
is: CHEBI:15347
initial concentration: 1.0
is: HMDB01659
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
constant: false
initial amount: NaN

metaM datp n
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
initial concentration: 1.0
constant: false
is: C00131
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
name: dATP
type: Species
is: CHEBI:61404

metaR FAOXTC101TC102m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaM pheme e
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Protoheme
is: C00032
type: Species
is: CHEBI:17627
is: HMDB03178

http://identifiers.org/biomodels.db/MODEL1310110051#_1b377bbf_a0a9_4705_a107_d2b70f757244
boundary condition: true
type: Species
name: SLC34A2
is encoded by: hsa:10568
has only substance units: false
constant: false
is: O95436
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r1595
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR ADSK
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.25
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
name: adenylyl-sulfate kinase
product: MODEL1310110051#
type: Reaction
is described by: ECO:0000269
fast: false

metaR r2128
reversible: true
reactant: MODEL1310110051#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
product: MODEL1310110051#
is described by: ECO:0000000

metaM 3ivcrn e
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C12H23NO5 CHARGE: 0
is: HMDB13336
initial concentration: 1.0
constant: false
type: Species
name: 3-hydroxy-isovaleryl carnitine

http://identifiers.org/biomodels.db/MODEL1310110051#_2f42867c_3546_47db_abf2_9232ba4a17ed
is encoded by: hsa:146712
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: B3GNTL1
boundary condition: true
constant: false
is: Q67FW5
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_342a4aa8_e037_47ec_ab5e_e517bfead437
initial amount: NaN
has only substance units: false
type: Species
name: _AI697028_1_m
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:AI697028

http://identifiers.org/biomodels.db/MODEL1310110051#_f339cc2f_a334_4b96_817e_2eeabeeedb26
initial concentration: NaN
type: Species
name: ND6
constant: false
is: Q7GXZ1
initial amount: NaN
is encoded by: hsa:4541
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110051#_f7aa102b_b752_489e_84ad_f1399625a29c
has only substance units: false
is encoded by: hsa:1545
initial amount: NaN
type: Species
name: CYP1B1
boundary condition: true
is: Q16678
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_65eee5b6_a88a_439e_af12_feb8384d8bce
is encoded by: hsa:3420
is: O43837
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: IDH3B
has only substance units: false

metaR C162OHe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaR RE0691C
name: RE0691
type: Reaction
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#

metaR FACOAL240
modifier: MODEL1310110051#
product: MODEL1310110051#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110051#
is: SBO:0000176
reactant: MODEL1310110051#
reversible: true

metaR G14T2g
reversible: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110051#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
modifier: MODEL1310110051#
is described by: ECO:0000000

metaM leuktrF4 c
type: Species
is: HMDB06465
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:27491
initial concentration: 1.0
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4

metaR r1596
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC02202 e
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false
boundary condition: false
is: CHEBI:57398
is: SBO:0000247
name: prostaglandin A1(1-)
initial concentration: 1.0

metaR r2127
type: Reaction
kinetic law: MODEL1310110051#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110051#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110051#_1966de47_1ad3_402a_8c5e_fa767251106b
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: A6NED0
initial amount: NaN
is encoded by: hsa:2954
name: GSTZ1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_917bb45f_b8f2_407f_bae4_00c493f1b35e
type: Species
has only substance units: false
is encoded by: hsa:9197
initial amount: NaN
name: SLC33A1
boundary condition: true
is: O00400
is: SBO:0000252
initial concentration: NaN
constant: false

metaR TETDECE1CRNe
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaM pail3p hs c
is: SBO:0000247
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
is: CHEBI:58088
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaR THBPT4ACAMDASE
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
reversible: false
is: SBO:0000176
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110051#
type: Reaction
fast: false

metaM pheme c
constant: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
initial concentration: 1.0
type: Species
name: Protoheme
is: CHEBI:17627
initial amount: NaN
has only substance units: false
is: HMDB03178
is: SBO:0000247
boundary condition: false

metaR LEUKTRD4t
is described by: ECO:0000269
kinetic law: MODEL1310110051#
name: leukotriene D4 transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction
is: SBO:0000185
fast: false

metaR S6TASE25ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
name: galactose-6-sulfate sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176

metaR DCMPDA
is version of: http://identifiers.org/ec-code/3.5.4.12
modifier: MODEL1310110051#
is described by: ECO:0000254
reversible: true
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
kinetic law: MODEL1310110051#
name: dCMP deaminase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD

metaR r0817
type: Reaction
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
reactant: MODEL1310110051#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_c554d268_d59f_4b6a_953c_b313a1b4aad6
has only substance units: false
type: Species
is encoded by: hsa:91734
constant: false
name: IDI2
is: Q9BXS1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r0818
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110051#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_aea7dc30_39fc_4437_8254_27f5c819a0b7
initial concentration: NaN
constant: false
name: _AA502753_1_m
type: Species
boundary condition: true
is encoded by: hsa:AA502753
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_9b72745f_55f8_43ef_9e0d_5a2cd9be6a2c
initial concentration: NaN
boundary condition: true
name: _AI091231_1_c
is encoded by: hsa:AI091231
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR ASPTA
kinetic law: MODEL1310110051#
product: MODEL1310110051#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
name: aspartate transaminase
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000176

metaM glygn5 e
initial concentration: 1.0
is: HMDB00131
boundary condition: false
type: Species
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
is: CHEBI:17754
notes: FORMULA: C12H21O11X CHARGE: 0
constant: false
initial amount: NaN
is: C00116
has only substance units: false
is: SBO:0000247

metaR IDOAASE1ly
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
fast: false
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction

metaM galside hs g
constant: false
is: CHEBI:12947
has only substance units: false
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

metaR 3HKYNAKGAT
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.7
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110051#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110051#

metaR ADNK1m
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false
is described by: ECO:0000000
name: adenosine kinase, mitochondrial
kinetic law: MODEL1310110051#
fast: false
type: Reaction

metaR GGH 10FTHF7GLUe
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110051#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR TETHEX3t
reversible: true
fast: false
reactant: MODEL1310110051#
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR RTOTALt
product: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
name: RTOTAL transport
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reactant: MODEL1310110051#
reversible: true

metaR METS
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.1.1.13
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: methionine synthase
fast: false
is described by: ECO:0000134
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
product: MODEL1310110051#
type: Reaction

metaR r0181
kinetic law: MODEL1310110051#
is: SBO:0000176
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110051#
modifier: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction

metaM dtmp m
initial concentration: 1.0
name: dTMP
has only substance units: false
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
boundary condition: false
is: HMDB01227
initial amount: NaN
type: Species
is: CHEBI:26999
is: SBO:0000247

metaM acgagbside hs c
initial amount: NaN
is: HMDB01659
name: alpha GalNAc globoside
has only substance units: false
is: CHEBI:15347
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_c4d725a5_d8d9_4696_baf3_59d6da02f957
is: P30084
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1892
name: ECHS1

metaR HTDCACBP
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR NACHEX18ly
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR FAOXC164C165x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR TYRCBOX
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110051#
is described by: ECO:0000134
name: L-Tyrosine carboxy-lyase
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
product: MODEL1310110051#
type: Reaction

metaR r1599
reactant: MODEL1310110051#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110051#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110051#

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_fb55b95e_09f9_4743_8879_1e797bbf1982
is encoded by: hsa:26503
is: Q9NRA2
constant: false
is: SBO:0000252
has only substance units: false
name: SLC17A5
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM 3ddecdicoa x
is: C05280
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
name: 3,6-dodecadienoylcoa
is: HMDB03952

metaR FAOXC15ATPx
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaM thr L c
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: L-threonine
is: CHEBI:16857
type: Species
is: HMDB00167

http://identifiers.org/biomodels.db/MODEL1310110051#_97b34d39_97ea_4b01_8bcb_4ef346baa257
name: _AA081045_1_m
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AA081045
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_f7ec1d08_23a3_4688_911d_1ddfaf3f3a72
constant: false
name: PFKFB2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5208
type: Species
is: O60825
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR FAOXC5C5DCc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR DNDPt37m
modifier: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
name: dUTP transport via dTDP antiport
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
reversible: false
is: SBO:0000185

metaM lneldccoa m
boundary condition: false
has only substance units: false
is: HMDB01064
initial amount: NaN
constant: false
name: linoelaidyl coenzyme A
type: Species
is: http://identifiers.org/pubchem.compound/5462164
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_0bb3d53b_212c_4df8_abae_1ac29f11f969
has only substance units: false
name: GMPS
is: P49915
type: Species
is encoded by: hsa:8833
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM galside hs e
name: D-galactosyl-N-acylsphingosine
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
is: CHEBI:12947

http://identifiers.org/biomodels.db/MODEL1310110051#_d23d7592_5a19_4db9_8e40_3946a5cf97a4
type: Species
is: O43677
is encoded by: hsa:4717
constant: false
initial concentration: NaN
name: NDUFC1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_3e5e7d10_7cbc_4d81_bbbd_acd96541f45b
is encoded by: hsa:195814
is: SBO:0000252
constant: false
is: B3KT84
initial amount: NaN
boundary condition: true
name: SDR16C5
has only substance units: false
initial concentration: NaN
type: Species

metaM vacccoa m
is: http://identifiers.org/pubchem.compound/9543677
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
name: vaccenyl coenzyme A
constant: false
is: HMDB06521

http://identifiers.org/biomodels.db/MODEL1310110051#_dc6f9d10_ac0c_4a66_b5db_208e748f40c7
is: Q99714
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: HSD17B10
is encoded by: hsa:3028
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_fcad1f75_c5d7_41e1_b503_b5704f60c176
is: Q3KQV9
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:91373
name: UAP1L1
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_e576bc36_b149_43b3_b147_b71a647dc801
initial concentration: NaN
initial amount: NaN
name: GBA
has only substance units: false
type: Species
is encoded by: hsa:2629
constant: false
boundary condition: true
is: B7Z6S9
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_0a475f2f_587d_45a3_818b_7a8d810813e2
type: Species
is: Q86VV3
is: SBO:0000252
initial amount: NaN
name: ENTPD1
has only substance units: false
is encoded by: hsa:953
initial concentration: NaN
boundary condition: true
constant: false

metaR C6DCc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_5ece9fbe_0963_438f_a2d7_d7bb2de51dce
initial concentration: NaN
name: PDE6A
has only substance units: false
constant: false
is: P16499
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5145
initial amount: NaN

metaR r0074
is described by: ECO:0000000
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110051#
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
modifier: MODEL1310110051#
product: MODEL1310110051#

metaM 3hexdtricoa x
is: HMDB02288
initial amount: NaN
has only substance units: false
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_57bcbe49_9b72_4239_918b_c9b7a1712e88
has only substance units: false
initial amount: NaN
name: LDHAL6B
type: Species
is encoded by: hsa:92483
is: Q9BYZ2
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM 2mop m
boundary condition: false
is: SBO:0000247
name: 2-methyl-3-oxopropanoate
is: HMDB01172
is: CHEBI:57700
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
constant: false

metaM 3hexdcoa m
constant: false
is: SBO:0000247
is: HMDB03932
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3-hydroxyhexadecanoylcoa
is: C05258
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_322abae4_2634_4148_bf51_037963799f24
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: O75610
name: LEFTY1
type: Species
is encoded by: hsa:10637
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_71715943_2bd6_4215_96d7_9e25a6dc211a
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:30
name: ACAA1
is: Q96CA6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_a6ff6f04_db61_4654_bee1_94974c886670
initial concentration: NaN
is encoded by: hsa:X63359
name: _X63359_1_c
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM 2maacoa m
is: HMDB01157
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: SBO:0000247
is: CHEBI:57335
initial concentration: 1.0
type: Species
has only substance units: false
name: 2-methylacetoacetyl-CoA(4-)

metaM lnlccoa c
is: HMDB01064
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial amount: NaN

metaR FADtx
fast: false
is: SBO:0000185
product: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
type: Reaction
is described by: ECO:0000000
name: FAD transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

http://identifiers.org/biomodels.db/MODEL1310110051#_c07a97a3_ca7e_425f_aec8_345a514cd358
name: GGH
is encoded by: hsa:8836
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: Q92820
constant: false
has only substance units: false

metaR FAOXC12C12OHm
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR r0186
kinetic law: MODEL1310110051#
is: SBO:0000176
fast: false
product: MODEL1310110051#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
reversible: false
reactant: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_ffdea38c_6249_4092_9db3_a1796aa5361a
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: PRPS2
initial concentration: NaN
is encoded by: hsa:5634
constant: false
is: P11908
boundary condition: true

metaR GALASE8ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110051#
is described by: ECO:0000000
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#

metaM lneldccoa c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/9543677
initial amount: NaN
constant: false
name: linoelaidyl coenzyme A
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06521

http://identifiers.org/biomodels.db/MODEL1310110051#_d4ae6fe2_7a2c_4a80_a22c_f7779fad1964
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
has part: Q86U05
initial concentration: NaN
name: SLC7A8:SLC3A2
is: SBO:0000297
is encoded by: hsa:23428

metaR ACCOAgt
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110051#
type: Reaction
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
reactant: MODEL1310110051#
name: acetyl-coa transport
product: MODEL1310110051#
modifier: MODEL1310110051#
is described by: ECO:0000269

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR RE3269C
modifier: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.3.48
reversible: true
name: RE3269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000000
type: Reaction

metaR G3PD1
is version of: http://identifiers.org/ec-code/1.1.1.8
type: Reaction
name: glycerol-3-phosphate dehydrogenase (NAD)
modifier: MODEL1310110051#
is described by: ECO:0000269
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
reversible: true

metaR PPD2CSPp
reversible: false
name: PPD2CSPp
kinetic law: MODEL1310110051#
product: MODEL1310110051#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reactant: MODEL1310110051#
is described by: ECO:0000000

metaR LINKDEG4ly
product: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
type: Reaction
reversible: false
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110051#_b628ecdc_0b5b_450f_9e4d_226b624f235a
is encoded by: hsa:2590
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: GALNT2
is: Q10471
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_c343f5c8_acd7_4aa9_85ac_782b0147b353
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:23556
name: PIGN
initial concentration: NaN
is: SBO:0000252

metaR ORNt4m
name: ornithine mitochondrial transport exchange with citruline
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: true
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
type: Reaction
fast: false
kinetic law: MODEL1310110051#

metaR CDSm
fast: false
modifier: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.41
reversible: false
kinetic law: MODEL1310110051#
product: MODEL1310110051#
name: phosphatidate cytidylyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
reactant: MODEL1310110051#
is: SBO:0000176

metaR FAOXC201C181x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM for e
is: SBO:0000247
is: HMDB00142
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:15740
initial amount: NaN
type: Species
name: formate
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false

metaR HSPGtly
is described by: ECO:0000000
type: Reaction
product: MODEL1310110051#
fast: false
name: heparan sulfate transport, extracellular to lysosome
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185

metaM dolmanp U c
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:15809
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Dolichyl phosphate D-mannose, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

metaR SPH1Pte
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
name: sph1p transport
is described by: ECO:0000000
reactant: MODEL1310110051#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#
reversible: true
fast: false

metaM galside hs l
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_488b79d6_4061_49e5_b52c_ff9ecbf490d2
is: SBO:0000252
constant: false
name: CA12
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:771
initial amount: NaN
has only substance units: false

metaM L2aadp m
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: HMDB00510
boundary condition: false
initial amount: NaN
is: CHEBI:58672
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: L-2-aminoadipate(1-)

metaM ddcacoa c
is: C01832
is: SBO:0000247
constant: false
is: HMDB03571
type: Species
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
is: CHEBI:57375
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0

metaR AG13T4g
fast: false
type: Reaction
modifier: MODEL1310110051#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110051#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#
reversible: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_50bf1a68_5d64_4af3_9b54_203a130c9567
boundary condition: true
is encoded by: hsa:1603
type: Species
initial concentration: NaN
is: SBO:0000252
name: DAD1
initial amount: NaN
is: Q53G02
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_394fc7ad_a4d8_4a50_b0b6_8b1ddf1e4fa6
initial amount: NaN
is: O14735
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: CDIPT
is encoded by: hsa:10423
has only substance units: false
initial concentration: NaN

metaM hexde7coa x
name: 7-hexadecenoylcoa
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: HMDB02288
type: Species
is: SBO:0000247

metaR r0706
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.10
is described by: ECO:0000000
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
kinetic law: MODEL1310110051#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaM dag hs e
has only substance units: false
is: CHEBI:18035
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
constant: false
boundary condition: false
name: diglyceride

metaM dolp U c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
name: dolichyl phosphate(2-)
has only substance units: false
is: CHEBI:57683

http://identifiers.org/biomodels.db/MODEL1310110051#_5c77e9b6_647d_4fce_9080_1125e62995a5
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NDUFS7
is encoded by: hsa:374291
constant: false
initial concentration: NaN
is: O75251
type: Species

metaM acnamp c
has only substance units: false
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
constant: false
is: HMDB06268
boundary condition: false
initial concentration: 1.0
name: N-Acetylneuraminate 9-phosphate
is: CHEBI:27438
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_c03f8dd9_4325_4873_8da8_9687f9175750
boundary condition: true
has only substance units: false
constant: false
name: IMPA1
is: B7Z6Q4
is encoded by: hsa:3612
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaR HMGLm
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
product: MODEL1310110051#
reversible: false
fast: false
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.3.4
name: hydroxymethylglutaryl-CoA lyase

http://identifiers.org/biomodels.db/MODEL1310110051#_5023d4bd_f879_4821_8e40_0981649613a7
boundary condition: true
is encoded by: hsa:5152
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: PDE9A

metaR FAOXC164C165m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_88e1bf13_5f50_41da_af0e_5edecaccafba
initial concentration: NaN
is encoded by: hsa:22934
name: RPIA
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: P49247
type: Species

metaR ADSS
is: SBO:0000176
product: MODEL1310110051#
reversible: false
fast: false
name: adenylosuccinate synthase
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#

metaR MI13PP
name: inositol-1,3-bisphosphate 3-phosphatase
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is: SBO:0000176
product: MODEL1310110051#
type: Reaction
reversible: false
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#

metaM cholcoads x
is: CHEBI:27505
constant: false
initial amount: NaN
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06889
is: SBO:0000247
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460

metaR DNDPt34m
is described by: ECO:0000269
product: MODEL1310110051#
is: SBO:0000185
reversible: false
fast: false
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
name: dGDP transport via dTDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110051#
type: Reaction

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_7dc5ee62_c0c9_4dcd_9bf8_6b1f7b4f9f5a
is: P19440
has only substance units: false
constant: false
is encoded by: hsa:2678
name: GGT1
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR PRAGSr
kinetic law: MODEL1310110051#
is: SBO:0000176
name: phosphoribosylglycinamide synthase
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110051#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110051#_d990d107_6f80_4613_915d_54ecb596f35f
is: O14975
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11001
initial amount: NaN
name: SLC27A2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_cf2ad977_3943_45fa_bbbd_bc951532c7e2
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: PRPS1L1
is: SBO:0000252
is encoded by: hsa:221823
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110051#_349dbd79_f442_448a_8efe_02395b64bf1a
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:19
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: O95477
name: ABCA1

metaM 5adtststerone e
initial amount: NaN
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: SBO:0000247
has only substance units: false
is: HMDB02961
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110051#_53bb6d94_56a5_4971_a3c8_2e803b2d638d
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: B2ZGL7
type: Species
constant: false
initial amount: NaN
name: MGLL
is encoded by: hsa:11343

metaR C18OHc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaM dag hs c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18035
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: diglyceride
has only substance units: false
type: Species

metaR NDPK2n
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is: SBO:0000176
reversible: true
reactant: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
kinetic law: MODEL1310110051#
type: Reaction
modifier: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM cysam c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58029
type: Species
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
constant: false
has only substance units: false
is: HMDB02991
initial amount: NaN
name: cysteaminium

http://identifiers.org/biomodels.db/MODEL1310110051#_475c05d6_05b0_4567_9514_c45609ea25c9
is: Q16822
is: SBO:0000252
is encoded by: hsa:5106
initial concentration: NaN
constant: false
name: PCK2
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR FACOAL241
is: SBO:0000176
name: fatty-acid--CoA ligase
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110051#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR KSII CORE4t
name: keratan sulfate II (core4) transport, golgi to extracellular
reactant: MODEL1310110051#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_4ac8e325_9ebd_44dc_b91c_11df8995e183
initial concentration: NaN
name: SPTLC1
initial amount: NaN
is: O15269
type: Species
constant: false
is encoded by: hsa:10558
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM c12dc c
has only substance units: false
type: Species
initial concentration: 1.0
name: dodecanedioyl carnitine
initial amount: NaN
notes: FORMULA: C19H34NO6 CHARGE: -1
constant: false
is: SBO:0000247
is: HMDB00623
boundary condition: false

metaR SUBERICACT
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR EX 3deccrn
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaM datp m
is: C00131
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01532
has only substance units: false
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
initial amount: NaN

metaR RE2974C
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
reversible: true
name: RE2974
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.149
is described by: ECO:0000000
fast: false
modifier: MODEL1310110051#
type: Reaction

metaR FAOXC226m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_ecd43362_cc0c_4aa4_a694_f41b7a39c01e
name: SGPL1
boundary condition: true
type: Species
is: O95470
initial amount: NaN
is encoded by: hsa:8879
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_8b21e9a8_da8d_452f_8df8_a446e205c6ab
is encoded by: hsa:65010
initial concentration: NaN
is: Q9Y3Y1
initial amount: NaN
boundary condition: true
name: SLC26A6
constant: false
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110051#_1dad60de_c343_4417_bd01_763dfc12470a
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLC5A10
is encoded by: hsa:125206
type: Species
is: A0PJK1
initial amount: NaN
constant: false
initial concentration: NaN

metaM 5adtststerone c
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
is: CHEBI:16330
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02961
type: Species

metaR FAOXC142C122x
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM odecoa c
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB01322
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: CHEBI:3793
name: Octadecenoyl-CoA (n-C18:1CoA)
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_32b98b3d_c6ba_42a7_ad71_335bf64d2a53
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5277
name: PIGA
has only substance units: false
is: SBO:0000252

metaM ocdececrn c
type: Species
initial amount: NaN
is: HMDB06351
name: 11-octadecenoyl carnitine
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0

metaM for c
name: Formate
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15740
type: Species
is: SBO:0000247
is: C00058
is: HMDB00142
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
initial amount: NaN

metaR NDP8
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110051#
modifier: MODEL1310110051#
name: nucleoside-diphosphatase (dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_42e08020_7adb_4bbc_80fd_b82048ca3f09
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:257068
is: Q0VAA5
constant: false
is: SBO:0000252
name: PLCXD2

metaR r2406
reactant: MODEL1310110051#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110051#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_7e64f131_7179_4cf3_b6fa_6856cf124594
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:2731
name: GLDC
is: P23378
is: SBO:0000252
initial amount: NaN
type: Species

metaR FBP26
product: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.105
type: Reaction
reactant: MODEL1310110051#
is: SBO:0000176
is described by: ECO:0000000
name: Fructose-2,6-bisphosphate 2-phosphatase
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/3.1.3.11
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
fast: false
kinetic law: MODEL1310110051#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_b47d9b0c_ceae_49b3_b160_1684932d8beb
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: P36969
name: GPX4
is: SBO:0000252
type: Species
is encoded by: hsa:2879

http://identifiers.org/biomodels.db/MODEL1310110051#_89c4be3b_719f_4d1b_81f5_4dc11a2618c8
has only substance units: false
is: Q6FGA0
type: Species
constant: false
name: COX7A2L
boundary condition: true
is encoded by: hsa:9167
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM tettet6coa c
boundary condition: false
name: tetracosatetraenoyl coenzyme A
is: HMDB06516
constant: false
is: http://identifiers.org/pubchem.compound/47205481
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
has only substance units: false
initial concentration: 1.0
is: C16171

metaM dhea c
has only substance units: false
boundary condition: false
type: Species
is: HMDB00077
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
constant: false
is: CHEBI:28689
name: 3beta-hydroxyandrost-5-en-17-one

metaR KCC2t
modifier: MODEL1310110051#
is described by: ECO:0000269
product: MODEL1310110051#
name: K+-Cl- cotransporter (NH4+)
kinetic law: MODEL1310110051#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is: SBO:0000185
reversible: true
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_26614485_1e47_4247_abb6_86efa8b2cd92
is encoded by: hsa:622
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: BDH1
initial amount: NaN
is: Q02338

metaM hs deg2 l
has only substance units: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
boundary condition: false
is: CHEBI:17180
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01352
initial amount: NaN
name: heparan sulfate, degradation product 2
type: Species

metaM chlstol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: CHEBI:16290
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: HMDB06842

metaR r1456
kinetic law: MODEL1310110051#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110051#
reversible: false
is described by: ECO:0000000
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_36765ac2_a840_41ca_9939_aefd1dd58de1
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA788780
constant: false
name: _AA788780_1_c

http://identifiers.org/biomodels.db/MODEL1310110051#_e347196b_663e_4e35_9316_26c77283d012
is encoded by: hsa:LOC727762
initial amount: NaN
type: Species
constant: false
name: _LOC727762_1_m
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR CO2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 peroxisomal transport
is: SBO:0000185
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reversible: true
fast: false
reactant: MODEL1310110051#
type: Reaction
is described by: ECO:0000000

metaR XYLt
name: D-xylose reversible transport
modifier: MODEL1310110051#
fast: false
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD

metaR DMATTx
reactant: MODEL1310110051#
type: Reaction
name: dimethylallyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/2.5.1.1
is described by: ECO:0000134
is: SBO:0000176
reversible: false
modifier: MODEL1310110051#
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#

metaM ksi pre29 g
is: CHEBI:28067
type: Species
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 29
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110051#_a933f66c_6246_4ec7_824e_a74a4d81fb7f
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10768
has only substance units: false
type: Species
name: AHCYL1
is: SBO:0000252
constant: false
is: O43865

http://identifiers.org/biomodels.db/MODEL1310110051#_600edd23_efa1_4614_ae3d_8f3e1f7e8f85
is: SBO:0000252
is encoded by: hsa:3101
constant: false
boundary condition: true
is: P52790
name: HK3
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaM ksi pre31 g
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
name: keratan sulfate I biosynthesis, precursor 31
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00130
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:58053
is: HMDB00175
boundary condition: false

metaM thp2c c
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: CHEBI:16987
has only substance units: false
initial amount: NaN
constant: false
name: 1-piperideine-6-carboxylate
is: SBO:0000247
is: HMDB12130
boundary condition: false
initial concentration: 1.0

metaR r2408
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110051#
kinetic law: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110051#
reactant: MODEL1310110051#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110051#_80ec1bb5_1095_423a_9b38_fb6302877691
name: _AF116616_1_m
is encoded by: hsa:AF116616
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaR r1455
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110051#
type: Reaction
reactant: MODEL1310110051#
name: Transport reaction
fast: false
is: SBO:0000185

metaR EX oagt3 hs LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GT3 (homo sapiens) exchange
type: Reaction

metaR LINOFATPtc
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaM ps hs m
has only substance units: false
boundary condition: false
initial amount: NaN
name: ps_hs[m]
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303

metaR MG2er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
kinetic law: MODEL1310110051#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110051#
product: MODEL1310110051#

metaR HSD17B4x
name: hydroxysteroid (17-beta) dehydrogenase 4
fast: false
product: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
type: Reaction

metaR TYRt
modifier: MODEL1310110051#
reactant: MODEL1310110051#
kinetic law: MODEL1310110051#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
name: L-tyrosine transport
product: MODEL1310110051#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110051#_1aed0e30_3bfd_4b0e_9d89_479ee2896640
has only substance units: false
initial amount: NaN
constant: false
name: FOLR1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:2348

metaM phyt x
boundary condition: false
is: CHEBI:37257
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
name: phytanate
is: SBO:0000247
is: HMDB00801

metaM c12dccoa x
name: dodecanedioylcoa
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB03712
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR PGLer
is: SBO:0000176
reactant: MODEL1310110051#
is version of: http://identifiers.org/ec-code/1.1.1.47
name: 6-phosphogluconolactonase, endoplasmic reticulum
reversible: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
is described by: ECO:0000269
kinetic law: MODEL1310110051#
modifier: MODEL1310110051#
type: Reaction
product: MODEL1310110051#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110051#_af872906_f456_4fb0_81be_1eb4251539fa
is: SBO:0000252
is: B7Z792
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: NDUFS2
is encoded by: hsa:4720
boundary condition: true
has only substance units: false

metaR FAOXC142C122m
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM ocdca c
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
has only substance units: false
is: HMDB00827
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: stearate
is: CHEBI:25629
initial amount: NaN

metaM ksi pre17 g
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 17
initial amount: NaN
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: SBO:0000247
has only substance units: false

metaR r2409
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110051#_ffce43da_b30c_496d_8ea3_72446a5c322f
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: INPP5J
has only substance units: false
is encoded by: hsa:27124

metaM abt c
is: HMDB01851
is: CHEBI:18403
type: Species
name: L-arabinitol
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false

metaR SERGLNexR
modifier: MODEL1310110051#
is: SBO:0000185
reactant: MODEL1310110051#
is described by: ECO:0000304
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110051#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110051#_95891dce_ef5e_4ed5_857c_5710f16ecb36
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR CO2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
name: CO2 transport (diffusion), mitochondrial
product: MODEL1310110051#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110051#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110051#
reversible: true

metaR PTDCACRNt
fast: false
is described by: ECO:0000000
modifier: MODEL1310110051#
type: Reaction
reversible: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
is: SBO:0000185
name: pentadecanoate transport into the mitochondria
reactant: MODEL1310110051#

http://identifiers.org/biomodels.db/MODEL1310110051#_cc55b4ff_edb8_4da6_b78d_3061b8570224
name: SUCLA2
boundary condition: true
is: SBO:0000252
type: Species
is: E5KS60
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8803

metaM s2l2n2m2mn l
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: HMDB00573
is: SBO:0000247
is: CHEBI:30825
has only substance units: false
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
initial amount: NaN
boundary condition: false

metaM apoC Lys m
name: Apocarboxylase (Lys residue)
boundary condition: false
has only substance units: false
type: Species
is: HMDB00182
is: CHEBI:32551
is: SBO:0000247
constant: false
notes: FORMULA: C6H13N2OX CHARGE: 0
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110051#_83756e77_2240_4a7a_9e43_7cd772aaef21
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _H77542_1_r
is encoded by: hsa:H77542
constant: false
initial concentration: NaN
type: Species

metaM estrones e
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
name: estrone 3-sulfate(1-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:60050
has only substance units: false
is: HMDB01425

metaR FACOAL1822
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110051#
name: fatty-acid--CoA ligase
reversible: true
modifier: MODEL1310110051#
reactant: MODEL1310110051#
is: SBO:0000176
product: MODEL1310110051#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110051#_18ec7327_567e_4a1c_94fe_ac42d9305959
initial amount: NaN
boundary condition: true
name: _AA532636_1_m
type: Species
initial concentration: NaN
is encoded by: hsa:AA532636
has only substance units: false
constant: false
is: SBO:0000252

metaR GLCSGLT1le
kinetic law: MODEL1310110051#
product: MODEL1310110051#
reactant: MODEL1310110051#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaR CHOLATEt
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110051#
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110051#
reversible: true
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
type: Reaction

metaR GALK
name: galactokinase
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is: SBO:0000176
modifier: MODEL1310110051#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.6
is version of: http://identifiers.org/ec-code/2.7.1.157
type: Reaction
is described by: ECO:0000000
reversible: false

metaM c8dc c
initial amount: NaN
is: C02838
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00791
is: SBO:0000247
name: suberyl carnitine
constant: false
has only substance units: false
notes: FORMULA: C15H26NO6 CHARGE: -1

metaM cs e deg5 l
is: SBO:0000247
notes: FORMULA: C31H47NO35S3 CHARGE: -4
boundary condition: false
constant: false
is: CHEBI:57737
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
type: Species
has only substance units: false
is: HMDB00868
initial concentration: 1.0

metaR r1453
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110051#
fast: false
type: Reaction
reactant: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8

http://identifiers.org/biomodels.db/MODEL1310110051#_2891a155_62a6_4644_9f81_c7a99b9902ef
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57171
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: DOLPP1
is: Q86YN1

metaM ocdca e
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
type: Species
is: HMDB00827
has only substance units: false
constant: false
name: octadecanoate (n-C18:0)
initial amount: NaN
is: CHEBI:25629
initial concentration: 1.0
boundary condition: false
is: C01530

metaM ksi pre7 g
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: C00130
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 7

http://identifiers.org/biomodels.db/MODEL1310110051#_4b3e0ec5_a5d1_4a06_a700_8c6fa40eab33
is: SBO:0000252
is: B7Z2M9
constant: false
initial concentration: NaN
type: Species
name: DGKZ
initial amount: NaN
is encoded by: hsa:8525
boundary condition: true
has only substance units: false

metaM btn m
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00030
is: CHEBI:57586
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
name: biotinate

metaR FAOXC204
modifier: MODEL1310110051#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
product: MODEL1310110051#
fast: false
reactant: MODEL1310110051#
reversible: false
kinetic law: MODEL1310110051#

metaR ASAH1
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110051#
type: Reaction
name: N-acylsphingosine amidohydrolase
is version of: http://identifiers.org/ec-code/3.5.1.23
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
kinetic law: MODEL1310110051#
reversible: false
product: MODEL1310110051#

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR DCK1n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110051#
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (ATP)
product: MODEL1310110051#
is: SBO:0000176
kinetic law: MODEL1310110051#
reactant: MODEL1310110051#
fast: false
reversible: true

metaR NDPK9
fast: false
kinetic law: MODEL1310110051#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:IDP)
type: Reaction
modifier: MODEL1310110051#
product: MODEL1310110051#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110051#

metaM ksi deg15 l
is: HMDB00143
is: CHEBI:12936
has only substance units: false
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 15
initial concentration: 1.0

metaR NACHEX22ly
reversible: false
product: MODEL1310110051#
kinetic law: MODEL1310110051#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110051#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110051#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal

metaM nm4masn g
has only substance units: false
is: SBO:0000247
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
initial amount: NaN
is: C05882
boundary condition: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110051#_57e90c2d_ec6f_4857_83da_9aacc809e9a2
initial concentration: NaN
constant: false
is encoded by: hsa:2645
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: GCK

http://identifiers.org/biomodels.db/MODEL1310110051#_e31ff702_c322_4105_b40c_55ec9b9b79b9
boundary condition: true
is encoded by: hsa:6579
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P46721
constant: false
name: SLCO1A2
type: Species

metaM abt e
constant: false
initial amount: NaN
name: L-arabinitol
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
type: Species
is: CHEBI:18403
has only substance units: false
is: HMDB01851

metaR FACOAL1821
reactant: MODEL1310110051#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
product: MODEL1310110051#
fast: false
kinetic law: MODEL1310110051#
is: SBO:0000176
reversible: true
modifier: MODEL1310110051#
type: Reaction
is described by: ECO:0000269