http://identifiers.org/biomodels.db/MODEL1310110050#_0af8ddbd_93e3_40ce_ae67_fb01f33c641d
boundary condition: true
has only substance units: false
is encoded by: hsa:79369
is: Q9C0J1
initial concentration: NaN
name: B3GNT4
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM ala B e
has only substance units: false
initial amount: NaN
is: CHEBI:16958
is: SBO:0000247
is: HMDB00056
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
name: beta-alanine

metaM dag hs n
name: diglyceride
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
initial amount: NaN
constant: false

metaR PROt4 2 r
is described by: ECO:0000006
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
name: Proline transport (sodium symport) (2:1)

http://identifiers.org/biomodels.db/MODEL1310110050#_0246c6fa_addc_4939_96ce_02c76a02a8f5
has part: Q86U05
has only substance units: false
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000297
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_75ff4572_6470_4d9f_9dca_d000a347ffad
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AI291895_1_c
initial amount: NaN
is encoded by: hsa:AI291895

metaR ACETONEt2
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
type: Reaction
name: acetone transport via proton symport
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_d9099ae8_1fa8_44ce_90aa_a5b76e8707fe
is encoded by: hsa:2720
has part: P10619
is encoded by: hsa:5476
has part: P34059
initial concentration: NaN
is encoded by: hsa:4758
name: GALNS:GLB1:NEU1:CTSA
constant: false
is encoded by: hsa:2588
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000297
has part: P16278
initial amount: NaN
has part: Q99519

metaR NPTHLte
name: xenobiotic transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
product: MODEL1310110050#
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_c33a08f9_abf9_4e67_a4d1_44da21ae384b
is encoded by: hsa:5464
initial amount: NaN
type: Species
is: Q15181
boundary condition: true
name: PPA1
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR ARACHt
fast: false
is described by: ECO:0000000
name: fatty acid transport via diffusion
kinetic law: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110050#
reversible: true

metaM HC01434 m
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: oxalatosuccinate(3-)
type: Species
is: CHEBI:58931
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

http://identifiers.org/biomodels.db/MODEL1310110050#_e2f9ba94_0c58_4201_ba39_f91d11d7b206
has only substance units: false
is encoded by: hsa:374291
type: Species
boundary condition: true
constant: false
name: NDUFS7
is: SBO:0000252
is: O75251
initial concentration: NaN
initial amount: NaN

metaM h c
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: C00080
initial concentration: 1.0
has only substance units: false
is: CHEBI:24636
initial amount: NaN
name: proton
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
is: SBO:0000247

metaR DHCR72r
reactant: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110050#
modifier: MODEL1310110050#
name: 7-dehydrocholesterol reductase
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.1.21
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3e696616_1975_4d3b_9ce8_85da1312da83
type: Species
is: Q92535
is encoded by: hsa:5279
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PIGC
boundary condition: true
constant: false
is: SBO:0000252

metaR S2TASE4ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.18 Confidence Level: 4 AUTHORS: PMID:2497731,PMID:4019466,PMID:8993162 NOTES:NCD
reactant: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
reversible: false
product: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: glucuronate-2-sulfatase, lysosomal

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_9841bccf_7f1c_4792_83b8_a1bff3262c7a
constant: false
name: _2544_1_c
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2544
type: Species
initial concentration: NaN

metaM xol7ah3 c
constant: false
initial concentration: 1.0
is: CHEBI:28540
boundary condition: false
is: HMDB12455
type: Species
is: SBO:0000247
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,26-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_fd8311a5_a6ab_4ebf_a567_bcc151a408f2
name: DGUOK
initial amount: NaN
is: Q16854
constant: false
is encoded by: hsa:1716
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

metaR r0641
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.4

http://identifiers.org/biomodels.db/MODEL1310110050#_3dfc5569_6a3e_4cce_ab1b_84b7eb188d3f
name: RFK
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:55312
is: B2RDZ2
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_3a85d008_0334_4740_a4ae_21e66d1d4307
initial amount: NaN
name: FUT8
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:2530
is: Q546E0
has only substance units: false
type: Species
boundary condition: true

metaM nac c
initial amount: NaN
constant: false
is: HMDB01488
is: SBO:0000247
boundary condition: false
is: C00253
has only substance units: false
is: CHEBI:0
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0
name: Nicotinate
type: Species

metaR HSAT2ly
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
type: Reaction

metaM dump m
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
is: SBO:0000247
name: dUMP(2-)
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB01409
is: CHEBI:246422

metaM ala B c
has only substance units: false
is: CHEBI:16958
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
type: Species
name: beta-alanine
is: HMDB00056
constant: false

metaM gthox c
is: C00127
has only substance units: false
is: HMDB03337
type: Species
is: CHEBI:58297
initial concentration: 1.0
name: Oxidized glutathione
initial amount: NaN
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
boundary condition: false
is: SBO:0000247

metaR 7DHCHSTEROLtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
name: cholesterol precursor intracellular transport
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
reactant: MODEL1310110050#

metaR DOLASNT Ler
type: Reaction
reversible: false
product: MODEL1310110050#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
reactant: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.119
modifier: MODEL1310110050#

metaR DHCHOLESTANATEtm
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
kinetic law: MODEL1310110050#
name: lipid, flip-flop intracellular transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110050#
fast: false

metaM nadp r
initial concentration: 1.0
is: SBO:0000247
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
initial amount: NaN
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
type: Species
is: CHEBI:58349
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_0e1d8a46_a8ca_402e_ace2_3bc0862ffdaa
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q53Y25
boundary condition: true
name: GCK
has only substance units: false
is encoded by: hsa:2645
type: Species

metaR FATP7t
is version of: http://identifiers.org/ec-code/6.2.1.7
name: fatty acid electroneutral transport
product: MODEL1310110050#
fast: false
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: true

metaM HC01408 m
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: 3-Oxohexanoyl-CoA
is: CHEBI:27648
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR C120CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaR VLCS2r
is: SBO:0000176
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110050#_4e9d7295_b03f_4bf7_b9b0_a47df84f3bdd
constant: false
is encoded by: hsa:6817
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SULT1A1
type: Species

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
initial amount: NaN
is: SBO:0000247
name: proton
constant: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: CHEBI:24636
has only substance units: false

metaM CE4872 c
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
type: Species
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0
is: HMDB00127
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:15748
is: SBO:0000247

metaR r0308
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
is: SBO:0000176

metaM CE0849 m
has only substance units: false
name: cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:57795
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaR CYTK11n
modifier: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110050#
name: cytidylate kinase (dCMP,dGTP),nuclear
reversible: true
is: SBO:0000176

metaR r0483
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reversible: true
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is: SBO:0000176
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_73ad5072_247d_46e9_8c8a_f0011647ade3
name: GMDS
is encoded by: hsa:2762
is: O60547
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM acrn x
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57589
is: HMDB00201
name: O-acetylcarnitine
is: SBO:0000247
initial concentration: 1.0

metaM nac e
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00253
initial concentration: 1.0
constant: false
is: CHEBI:0
is: HMDB01488
name: Nicotinate
is: SBO:0000247

metaM 2mbcoa m
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: 2-methylbutanoyl-CoA(4-)
is: HMDB01041
initial concentration: 1.0
is: CHEBI:57336
type: Species

metaR PGDI
fast: false
name: Prostaglandin-H2 D-isomerase [Precursor]
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.2
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_daeb58c1_44f4_4782_b33d_d0d3f4ee7d37
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA278423
type: Species
boundary condition: true
name: _AA278423_1_c

metaM glutcoa c
is: SBO:0000247
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
initial amount: NaN
has only substance units: false
type: Species
name: glutaryl-CoA(5-)
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01339

http://identifiers.org/biomodels.db/MODEL1310110050#_afa458fb_7074_448b_a0ad_c76e5ddada3b
constant: false
is encoded by: hsa:2678
boundary condition: true
name: GGT1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P19440
initial amount: NaN

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM k c
constant: false
boundary condition: false
is: CHEBI:29103
has only substance units: false
is: C00238
initial amount: NaN
name: potassium
type: Species
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: SBO:0000247
initial concentration: 1.0
is: HMDB00586

metaR D LACt2
kinetic law: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
fast: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
name: D-lactate transport via proton symport

metaM imp e
type: Species
initial concentration: 1.0
name: IMP(2-)
is: HMDB00175
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58053
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130

metaM nadp x
constant: false
is: HMDB00217
is: CHEBI:58349
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
type: Species
is: C00006
initial amount: NaN

metaR r0642
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false

metaR NADtx
product: MODEL1310110050#
reversible: true
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of NAD into peroxisome
fast: false
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_06885986_94e2_4f8a_bd13_165cde6caf70
type: Species
name: BCAT2
is encoded by: hsa:587
is: O15382
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR VLCS2p
is: SBO:0000176
modifier: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: Very-long-chain-fatty-acid-CoA ligase
product: MODEL1310110050#
fast: false

metaM h g
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
initial concentration: 1.0
boundary condition: false

metaM lac D e
is: CHEBI:16004
is: SBO:0000247
is: HMDB01311
initial concentration: 1.0
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial amount: NaN
name: (R)-lactate
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_b3d5bef5_2eb3_46af_ae52_735a15d96b11
is: SBO:0000252
is encoded by: hsa:8818
constant: false
type: Species
is: O94777
boundary condition: true
name: DPM2
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR ALASm
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
fast: false
name: 5-aminolevulinate synthase
is described by: ECO:0000254
reactant: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.29
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.37
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_229d39b1_8ebf_41af_be2c_84465a339300
constant: false
initial amount: NaN
has only substance units: false
is: Q01415
is encoded by: hsa:2585
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: GALK2

metaR MTHFD2
is: SBO:0000176
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110050#
name: methylenetetrahydrofolate dehydrogenase (NAD)
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
type: Reaction
product: MODEL1310110050#

metaM k e
is: HMDB00586
initial amount: NaN
constant: false
name: potassium
is: C00238
is: CHEBI:29103
initial concentration: 1.0
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaM lald D c
name: (R)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: HMDB06458
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:17167

metaR r1150
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
name: Facilitated diffusion
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM imp c
boundary condition: false
initial concentration: 1.0
name: IMP
initial amount: NaN
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: SBO:0000247
constant: false
is: C00130
is: CHEBI:58053
type: Species
has only substance units: false
is: HMDB00175

metaR r0644
reactant: MODEL1310110050#
product: MODEL1310110050#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
is: SBO:0000176
fast: false
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
is described by: ECO:0000000

metaR HIBDm
reactant: MODEL1310110050#
is described by: ECO:0000269
type: Reaction
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is version of: http://identifiers.org/ec-code/1.1.1.31
fast: false
reversible: true
product: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176

metaR RE3218C
is: SBO:0000176
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
type: Reaction
kinetic law: MODEL1310110050#
name: RE3218
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true
fast: false

metaR FAOXC101C8m
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR TIGCRNe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaR r0480
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaM xol7ah3 m
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB12455
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,26-triol
constant: false
is: SBO:0000247
is: CHEBI:28540
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444

metaM glu L e
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00148
is: CHEBI:29985
has only substance units: false
type: Species
initial concentration: 1.0
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247

metaR P4507A1r
is version of: http://identifiers.org/ec-code/1.14.13.17
product: MODEL1310110050#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110050#
reversible: false
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000269
reactant: MODEL1310110050#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:

metaM HC00361 c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: sedoheptulose 1,7-bisphosphate(4-)
boundary condition: false
initial amount: NaN
is: CHEBI:58335
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
type: Species
constant: false

metaR DHCRD1
type: Reaction
kinetic law: MODEL1310110050#
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
modifier: MODEL1310110050#
is described by: ECO:0000269
name: dihydroceramide desaturase
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_a57b2ecd_ba68_427d_8b33_055254a3665b
initial amount: NaN
name: SLC5A8
is encoded by: hsa:160728
type: Species
has only substance units: false
is: SBO:0000252
is: Q8N695
boundary condition: true
initial concentration: NaN
constant: false

metaM cdpdag hs m
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: CDP-diacylglycerol(2-)
initial amount: NaN
is: CHEBI:58332

http://identifiers.org/biomodels.db/MODEL1310110050#_ae2af9e7_b6f7_42f0_bfff_ce69ef47b3ab
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NDUFS8
constant: false
is: O00217
is encoded by: hsa:4728
type: Species
has only substance units: false
initial concentration: NaN

metaR r0752
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false

metaR r1156
is: SBO:0000176
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: MODEL1310110050#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
kinetic law: MODEL1310110050#

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_4fd39183_4410_4b9d_b3dc_15a0b1894d3c
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1718
initial concentration: NaN
boundary condition: true
is: Q15392
constant: false
name: DHCR24

metaM rib D c
type: Species
constant: false
is: CHEBI:16988
is: HMDB00283
has only substance units: false
boundary condition: false
name: D-ribose
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_2386437b_7e13_4a28_bda3_16e73bd11142
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:3939
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P00338
initial concentration: NaN
name: LDHA

http://identifiers.org/biomodels.db/MODEL1310110050#_b5854263_fba9_4e34_92db_223a2f1190cc
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:9152
is: SBO:0000252
type: Species
name: SLC6A5
is: Q9Y345

http://identifiers.org/biomodels.db/MODEL1310110050#_9261052b_cb1a_4fa7_9de1_3155e59e226a
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: GCNT4
is encoded by: hsa:51301
has only substance units: false
is: Q9P109
initial amount: NaN

metaR MALtm
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is described by: ECO:0000269
product: MODEL1310110050#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
name: malate transport, mitochondrial

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR r1997
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110050#
reversible: false
is described by: ECO:0000000

metaR r0754
reactant: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true

metaR FAOXC16OHC16r
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaM ga2 hs g
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:465284
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
name: GA2

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
product: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
reversible: false
fast: false

metaM thbpt c
constant: false
is: HMDB00027
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial amount: NaN
boundary condition: false
has only substance units: false
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM core6 l
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
boundary condition: false
is: CHEBI:12936
has only substance units: false
is: HMDB00143
type: Species
constant: false
is: SBO:0000247
name: Core 6
initial concentration: 1.0

metaM lnlc e
name: linoleate
has only substance units: false
is: SBO:0000247
is: HMDB00673
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245
initial amount: NaN
constant: false

metaR DHORTS
product: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000269
name: dihydroorotase
fast: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
type: Reaction
reactant: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.3.2

metaR CYOR u10m
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110050#
is: SBO:0000185
name: ubiquinol-6 cytochrome c reductase, Complex III
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.5.1.92
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_2b7aa0b3_7a67_40cd_a57e_212ae19432b9
initial amount: NaN
is: Q6IB54
type: Species
name: ATP5J
boundary condition: true
is encoded by: hsa:522
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaR r1998
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#

metaM ala B m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16958
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
is: HMDB00056
type: Species
boundary condition: false
constant: false

metaM acgam c
is: SBO:0000247
name: N-acetyl-D-glucosamine
constant: false
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
is: CHEBI:17411
has only substance units: false
boundary condition: false
type: Species
is: HMDB00215

metaR r0753
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
product: MODEL1310110050#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
modifier: MODEL1310110050#
reversible: true
is: SBO:0000176

metaR HEXDICOAACBP
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaM xol7ah2 c
name: 5beta-cholestane-3alpha,7alpha-diol
type: Species
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28047
has only substance units: false
is: HMDB06893
constant: false
initial concentration: 1.0

metaM HC01434 x
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58931
name: oxalatosuccinate(3-)
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaR EX c51crn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM dag hs r
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
constant: false
is: SBO:0000247
is: CHEBI:18035
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM 34dhoxmand c
is: CHEBI:27637
initial concentration: 1.0
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
name: 3,4-Dihydroxymandelate
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01866

http://identifiers.org/biomodels.db/MODEL1310110050#_2279f2a1_509a_4aaf_8430_9d25a0b66289
is: Q92835
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: INPP5D
initial amount: NaN
is encoded by: hsa:3635
initial concentration: NaN

metaR GLYCtm
fast: false
name: glycerol transport
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110050#

metaM core6 g
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
has only substance units: false
is: C04383
initial amount: NaN
constant: false
name: Core 6

http://identifiers.org/biomodels.db/MODEL1310110050#_4b4b5084_23a4_400c_b070_1d8e6857310e
is: SBO:0000252
is encoded by: hsa:7084
boundary condition: true
type: Species
is: O00142
initial concentration: NaN
name: TK2
has only substance units: false
constant: false
initial amount: NaN

metaM dcacoa x
is: SBO:0000247
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: C05274
initial amount: NaN
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
constant: false
is: CHEBI:61430
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_58bb0020_ae73_45aa_905f_daf0d8a56b28
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: DPM2
is encoded by: hsa:8818

metaR DOLPMT L
kinetic law: MODEL1310110050#
fast: false
name: Dolichyl-phosphate D-mannosyltransferase (liver)
is: SBO:0000176
reactant: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.83
type: Reaction
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
product: MODEL1310110050#
is described by: ECO:0000000

metaR r2347
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
fast: false
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true

metaM dump n
is: SBO:0000247
is: CHEBI:246422
initial concentration: 1.0
name: dUMP(2-)
boundary condition: false
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_6069b434_d70a_4e66_bc0c_dfdeed1619fd
type: Species
initial concentration: NaN
is encoded by: hsa:2821
initial amount: NaN
has only substance units: false
is: P06744
constant: false
is: SBO:0000252
boundary condition: true
name: GPI

http://identifiers.org/biomodels.db/MODEL1310110050#_22b7e161_6e0a_4afa_b6e4_1c622b9e1c5b
is: SBO:0000252
boundary condition: true
name: ACAA1
is: Q96CA6
is encoded by: hsa:30
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaR ASCBt4
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
type: Reaction
is: SBO:0000185
reversible: true
name: L-ascorbate transport via proton symport
modifier: MODEL1310110050#

metaR r1996
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM ddcacoa x
is: SBO:0000247
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
initial concentration: 1.0
is: CHEBI:57375
is: C01832
has only substance units: false
is: HMDB03571
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species

metaM occoa c
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
is: C01944
has only substance units: false
type: Species
is: HMDB01070
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
is: CHEBI:57386
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_a4afe656_a522_434a_896c_6de462100ab5
name: AK3
constant: false
type: Species
is encoded by: hsa:50808
is: SBO:0000252
is: E7ET30
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR S4TASE2ly
product: MODEL1310110050#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_86e50909_996f_438f_8285_6d6f268b23fd
is: B7Z3I7
initial concentration: NaN
type: Species
is encoded by: hsa:4190
constant: false
initial amount: NaN
boundary condition: true
name: MDH1
has only substance units: false
is: SBO:0000252

metaR CSBPASEly
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110050#
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
type: Reaction
reactant: MODEL1310110050#

metaM gln L m
is: SBO:0000247
has only substance units: false
is: CHEBI:18050
type: Species
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
name: L-glutamine
boundary condition: false
is: HMDB00641
constant: false

metaM glu L c
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
is: CHEBI:29985
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_1427f0e3_2c6a_4c36_b42f_ef0917ca31b9
type: Species
constant: false
is: Q9Y2Q0
boundary condition: true
initial amount: NaN
is encoded by: hsa:10396
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ATP8A1

http://identifiers.org/biomodels.db/MODEL1310110050#_bc28202f_ce6e_4d65_9cb7_c83a17421a88
initial amount: NaN
is encoded by: hsa:953
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
is: Q86VV3
name: ENTPD1

http://identifiers.org/biomodels.db/MODEL1310110050#_f2921dad_c072_46ba_b1ef_c6d82eddfa43
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1557
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: CYP2C19
is: P33261

http://identifiers.org/biomodels.db/MODEL1310110050#_dfc289c9_bcf9_436e_aa45_7807d23c5cae
constant: false
is: O75747
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: PIK3C2G
initial amount: NaN
is encoded by: hsa:5288
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5ca5aa5f_b789_4dc8_a959_e5c08a69ecd3
initial concentration: NaN
boundary condition: true
type: Species
name: CHDH
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55349
constant: false
initial amount: NaN
is: Q8NE62

http://identifiers.org/biomodels.db/MODEL1310110050#_92cd1836_d745_40b5_8a9a_1c534b825e7f
constant: false
initial concentration: NaN
is encoded by: hsa:R14373
type: Species
name: _R14373_1_x
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_16240a3a_d608_4e88_ab4c_ba4dc95c81a3
is encoded by: hsa:205
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: AK4
has only substance units: false
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_9f3c2970_d555_4899_84b6_267109fab42b
initial amount: NaN
is: Q9Y6K8
name: AK5
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:26289
type: Species
constant: false

metaR r0750
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
reversible: true
is: SBO:0000176
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
fast: false

metaM pa hs c
initial amount: NaN
is: CHEBI:57739
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: phosphatidate(2-)
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

http://identifiers.org/biomodels.db/MODEL1310110050#_a344cad4_3d47_4d0a_8364_1cf5b28e5b80
constant: false
initial amount: NaN
boundary condition: true
is: P51606
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: RENBP
is encoded by: hsa:5973

metaR HYXNt
modifier: MODEL1310110050#
name: Hypoxanthine transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaR B3GALT44g
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.62
name: Beta-1,3-galactosyltransferase 4
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_4746e885_382c_49b0_927a_6411a37ecd53
initial concentration: NaN
is: SBO:0000252
type: Species
name: ACOT8
is encoded by: hsa:10005
is: O14734
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaR EX c101crn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_b677cdb7_f35c_4d37_ad60_9d56f02a1cb9
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:443
boundary condition: true
name: ASPA
is: Q6FH48

metaM m2mpdol L c
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28049
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM dgtp n
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16497
name: dGTP
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
is: C00286
is: HMDB01440
boundary condition: false

metaM HC00695 m
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: SBO:0000247
name: S-Succinyldihydrolipoamide
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:17432
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_ce2cb2b9_e228_4aaa_8c48_c81a6106d704
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: P09669
name: COX6C
is encoded by: hsa:1345
constant: false

metaM rib D e
name: D-ribose
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: HMDB00283
initial amount: NaN
is: CHEBI:16988
has only substance units: false
boundary condition: false

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaM aflatoxin e
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C17H12O6 CHARGE: 0 INCHI: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
type: Species
name: aflatoxin B1
is: CHEBI:2504
is: HMDB06552
constant: false
initial concentration: 1.0

metaR r2356
type: Reaction
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR GGH 5THFe
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
name: Gamma-glutamyl hydrolase (5THF), extracellular
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110050#
reversible: false
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_458adb75_8402_4896_aa50_2f5d7272c364
boundary condition: true
is encoded by: hsa:6534
name: SLC6A7
type: Species
initial concentration: NaN
initial amount: NaN
is: Q99884
has only substance units: false
constant: false
is: SBO:0000252

metaR P4502F1
name: cytochrome P450 2F1
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1572.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:1974816 NOTES:naphthalene epoxidation assumed to take place on outer membrane NJ
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.14.14.1
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR PIt8
name: phosphate transport in/out via Na+ symporter
fast: false
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
is described by: ECO:0000006

metaR NACHEXA7ly
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110050#

metaR GPIDA2er
fast: false
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
reactant: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
modifier: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: false

metaM idp c
name: IDP(3-)
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
initial amount: NaN
boundary condition: false
is: CHEBI:58280

metaR THFt2
fast: false
reversible: true
type: Reaction
name: tetrahydrofolate transport via anion exchange
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES:IT
modifier: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR r2355
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000000
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110050#
type: Reaction

metaR XYLt
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
fast: false
type: Reaction
name: D-xylose reversible transport
is described by: ECO:0000269
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD

metaR r0055
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is version of: http://identifiers.org/ec-code/2.4.2.7
reactant: MODEL1310110050#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.8
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
type: Reaction
product: MODEL1310110050#
modifier: MODEL1310110050#

metaM ddcacoa m
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57375
constant: false
is: C01832

metaR SUBERCROT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_bd8dbadf_a76a_4449_ba4b_0edb703a0e88
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:1633
is: SBO:0000252
is: P27707
constant: false
name: DCK
boundary condition: true
initial concentration: NaN

metaM 3mob c
is: CHEBI:11851
boundary condition: false
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaR r2358
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110050#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaR HACD9m
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
modifier: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000134
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial

metaM ksi pre23 g
initial concentration: 1.0
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 23
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaR CSNATer
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
is: SBO:0000176
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110050#
is described by: ECO:0000254
reversible: true
type: Reaction
modifier: MODEL1310110050#
name: carnitine O-acetyltransferase, endolasmic reticulum

metaR H2O2tp
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reversible: true
product: MODEL1310110050#
type: Reaction
name: hydrogen peroxide peroxisomal transport via diffusion
reactant: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_d496bd11_a403_4da0_930b_7b950e5c6eb4
constant: false
initial amount: NaN
is encoded by: hsa:122622
name: ADSSL1
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: B3KTV4
has only substance units: false

metaM g2m8mpdol L r
has only substance units: false
is: SBO:0000247
constant: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
initial amount: NaN
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
boundary condition: false
is: C05870
initial concentration: 1.0

metaM idp e
type: Species
name: IDP(3-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB03335
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
is: CHEBI:58280
constant: false

metaM aicar e
type: Species
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
is: HMDB01517
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13N4O8P CHARGE: -2
boundary condition: false
is: C04677
is: SBO:0000247
is: CHEBI:58475
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_d9071d1e_5672_4505_b0df_34c9e9f6e345
is encoded by: hsa:R39999
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: _R39999_1_c
is: SBO:0000252

metaM msa m
name: 3-oxopropanoate
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: HMDB11111
boundary condition: false
is: CHEBI:33190
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_48f247ca_c48a_44e8_8168_e61c38f1ccfd
name: ACADVL
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:37
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P49748

http://identifiers.org/biomodels.db/MODEL1310110050#_5f841576_d026_4856_a4cf_2d8ee1fdb750
constant: false
boundary condition: true
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
type: Species
has only substance units: false
is encoded by: hsa:516
has part: Q6FIH7

metaR r2357
reactant: MODEL1310110050#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_aba2a881_7442_41d7_878f_25401c6a73a0
is: Q9H2X9
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: SLC12A5
type: Species
is encoded by: hsa:57468
initial concentration: NaN
is: SBO:0000252

metaM didp n
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247
has only substance units: false
name: dIDP
is: CHEBI:28823
boundary condition: false
type: Species
is: HMDB03536

metaM hs deg13 l
constant: false
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: HMDB06254
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 13
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaR GLCt4
type: Reaction
modifier: MODEL1310110050#
reversible: true
product: MODEL1310110050#
is described by: ECO:0000269
name: glucose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
reactant: MODEL1310110050#

metaM 3mob e
is: CHEBI:11851
is: HMDB00019
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM dem2emgacpail prot hs r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:27979

http://identifiers.org/biomodels.db/MODEL1310110050#_34ffee78_dc5f_4e7a_a259_9bc8c25c62bd
initial concentration: NaN
name: PIK3R5
is encoded by: hsa:23533
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q8WYR1

http://identifiers.org/biomodels.db/MODEL1310110050#_0c454e5b_9936_420c_bbcc_81aa376f777b
is: SBO:0000297
initial amount: NaN
boundary condition: true
type: Species
constant: false
has part: P15531
initial concentration: NaN
has part: P22392
is encoded by: hsa:4830
has only substance units: false
name: NME1:NME2
is encoded by: hsa:4831

metaR HSPGtly
is: SBO:0000185
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: heparan sulfate transport, extracellular to lysosome
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
fast: false

metaR r2132
fast: false
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110050#
reversible: true
is described by: ECO:0000000

metaR 3MOBte
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of 3-methyl-2-oxobutanoate
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110050#
reversible: true

metaM r5p r
name: alpha-D-Ribose 5-phosphate
is: SBO:0000247
is: HMDB00618
initial concentration: 1.0
boundary condition: false
is: CHEBI:18189
type: Species
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
initial amount: NaN

metaR r0365
modifier: MODEL1310110050#
type: Reaction
reversible: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000176
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
reactant: MODEL1310110050#

metaR RE1530C
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
name: RE1530
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
type: Reaction

metaR r2352
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
name: Organic anion transporter 5 Utilized transport

metaR EX ptth LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ptth
type: Reaction

metaR r0801
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
is: SBO:0000185
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
type: Reaction

metaM CE4872 m
is: CHEBI:15748
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: HMDB00127
type: Species
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r0755
is: SBO:0000176
reactant: MODEL1310110050#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
fast: false

metaM m1mpdol L c
constant: false
is: CHEBI:28067
has only substance units: false
boundary condition: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

metaM aicar c
constant: false
is: HMDB01517
initial concentration: 1.0
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: SBO:0000247
initial amount: NaN
is: CHEBI:58475
boundary condition: false
is: C04677
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_cfca5e11_b037_43ee_b72c_75ea99e6fb1b
name: PIGQ
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9BRB3
type: Species
is encoded by: hsa:9091
constant: false
boundary condition: true

metaM cs c deg3 l
boundary condition: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
is: CHEBI:15748
is: SBO:0000247
constant: false
is: HMDB00127
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaM h x
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: C00080
name: proton

metaR ACONTm
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
name: Aconitate hydratase
is version of: http://identifiers.org/ec-code/4.2.1.3

metaM dodecanac c
is: HMDB00623
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C12H20O4 CHARGE: -2
name: Dodecanedioic acid
boundary condition: false

metaM hs deg16 l
has only substance units: false
initial amount: NaN
name: heparan sulfate, degradation product 16
is: SBO:0000247
boundary condition: false
is: CHEBI:21338
is: HMDB02704
constant: false
type: Species
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
initial concentration: 1.0

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM hs deg24 l
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C31H50NO26 CHARGE: -1
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16126
is: SBO:0000247
name: GlcNAc-GlcA-(Gal)2-Xyl

metaM chito2pdol L c
initial amount: NaN
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
is: HMDB01196
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:12427

metaM dgtp c
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
name: dGTP
initial concentration: 1.0
is: HMDB01440
has only substance units: false

metaR LINOFATPtc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR r2131
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM aflatoxin c
type: Species
name: aflatoxin B1
constant: false
boundary condition: false
is: CHEBI:2504
has only substance units: false
notes: FORMULA: C17H12O6 CHARGE: 0 INCHI: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB06552

metaR GCCam
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
is described by: ECO:0000269
name: glycine-cleavage complex (lipoylprotein), mitochondrial
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_baeda6a9_1852_44e3_873f_c41714723c0b
constant: false
initial amount: NaN
name: ALG3
has only substance units: false
is encoded by: hsa:10195
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_e235e2e3_cc9a_43fc_ac50_b46a1dba8769
is: SBO:0000252
initial amount: NaN
is: Q53XN1
is encoded by: hsa:1351
name: COX8A
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM occoa m
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
is: C01944
has only substance units: false
initial amount: NaN
is: HMDB01070
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57386
constant: false

metaM carn c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15727
name: carnosine
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: HMDB00033

metaM 34dhoxmand m
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: HMDB01866
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaR r2354
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
is: SBO:0000185
product: MODEL1310110050#

metaM hretn c
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: 4 hydroxy retinoic acid
is: HMDB06254
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H27O3 CHARGE: -1

metaR r2130
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110050#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR 5ADTSTSTERONESte
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
name: sulfonated testosterone transport
kinetic law: MODEL1310110050#
is: SBO:0000185

metaM CE0785 m
boundary condition: false
is: CHEBI:57795
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial amount: NaN
constant: false
is: SBO:0000247
name: cis,cis-myristo-5,8-dienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110050#_c2d36ed6_a178_4c2b_a40b_6f27af6f0875
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: B4DIA3
is encoded by: hsa:6535
boundary condition: true
initial concentration: NaN
name: SLC6A8

metaR BTND1n
fast: false
product: MODEL1310110050#
modifier: MODEL1310110050#
name: biotinidase (biotin), nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.12
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reversible: false
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110050#

metaM ncam e
type: Species
constant: false
initial amount: NaN
is: HMDB01406
boundary condition: false
initial concentration: 1.0
is: C00153
notes: FORMULA: C6H6N2O CHARGE: 0
is: CHEBI:0
has only substance units: false
name: Nicotinamide
is: SBO:0000247

metaM CE4876 r
boundary condition: false
name: delta12-Prostaglandin J2
is: SBO:0000247
initial amount: NaN
is: CHEBI:57923
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaM HC01403 x
type: Species
boundary condition: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
name: (S)-Hydroxydecanoyl-CoA
has only substance units: false
is: CHEBI:28325
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_b4be51fb_8999_4014_b877_31538ceeaddd
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:38
boundary condition: true
is: P24752
initial amount: NaN
type: Species
constant: false
name: ACAT1

http://identifiers.org/biomodels.db/MODEL1310110050#_e111dc97_8c72_4947_a4a6_a328eb078945
name: ST8SIA5
is encoded by: hsa:29906
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O15466
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR r2353
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_6cebdfd9_e23f_476b_a2cb_893b9ddf9351
type: Species
is: SBO:0000252
is encoded by: hsa:48
is: P21399
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: ACO1

http://identifiers.org/biomodels.db/MODEL1310110050#_35e31f5a_5a2d_4588_856d_bcbb5110a0eb
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC12A7
has only substance units: false
is encoded by: hsa:10723
initial concentration: NaN
constant: false
type: Species
is: Q9Y666

metaM fadh2 c
has only substance units: false
constant: false
is: HMDB01197
initial concentration: 1.0
is: CHEBI:58307
initial amount: NaN
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
name: FADH2(2-)
is: SBO:0000247

metaM cdpdag hs c
initial concentration: 1.0
initial amount: NaN
name: CDP-diacylglycerol(2-)
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
has only substance units: false

metaM dudp c
is: HMDB01000
constant: false
type: Species
name: dUDP
is: SBO:0000247
has only substance units: false
is: CHEBI:60471
initial amount: NaN
is: C01346
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0

metaM dgtp e
is: CHEBI:16497
is: HMDB01440
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
name: dGTP
initial concentration: 1.0

metaR PIt7
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
modifier: MODEL1310110050#
name: phosphate transport in/out via three Na+ symporter
type: Reaction
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is described by: ECO:0000269

metaR MG3er
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
is: SBO:0000176
type: Reaction

metaM ddcacoa c
is: CHEBI:57375
type: Species
is: SBO:0000247
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
is: HMDB03571
is: C01832
initial amount: NaN
initial concentration: 1.0

metaM 5mthf e
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
type: Species
is: C00440
name: 5-Methyltetrahydrofolate
has only substance units: false
is: SBO:0000247
is: CHEBI:3729
constant: false
is: HMDB01396
initial concentration: 1.0
boundary condition: false

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaM cs d deg6 l
initial concentration: 1.0
notes: FORMULA: C23H35O27S2 CHARGE: -3
is: CHEBI:16953
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00812
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 6

metaR PI45P5Pn
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110050#
type: Reaction
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
fast: false
reactant: MODEL1310110050#

metaR RETI2
name: retinol isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110050#

metaM ura e
boundary condition: false
constant: false
initial concentration: 1.0
name: uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
initial amount: NaN
is: CHEBI:17568
has only substance units: false
is: SBO:0000247
type: Species

metaR EX decdicrn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaR EX c3dc
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaM cs c deg5 l
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
is: CHEBI:15936
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C23H36O24S CHARGE: -2
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

metaM pail45p hs c
type: Species
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r0474
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110050#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000

metaR r2136
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110050#
product: MODEL1310110050#

metaM apoC m
has only substance units: false
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: XH CHARGE: 0
is: CHEBI:32551
constant: false
is: SBO:0000247
name: Apocarboxlase (no lys residue)
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_434ec8bf_be56_4a82_bab5_c82fea2a6f84
name: _U52111_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:U52111

metaM gthox m
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58297
constant: false
is: HMDB03337

metaR CYTK4n
type: Reaction
fast: false
modifier: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
name: cytidylate kinase (dCMP,GTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110050#
is described by: ECO:0000269
reversible: true
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR DGULND
fast: false
reactant: MODEL1310110050#
name: dehydro-L-gulonate decarboxylase
type: Reaction
reversible: true
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_517a588b_17ad_4bc5_8134_7f32201523f1
is encoded by: hsa:222
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P48448
constant: false
type: Species
name: ALDH3B2
has only substance units: false

metaR RETI1
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110050#
name: retinol isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
product: MODEL1310110050#

metaM xan c
name: Xanthine
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00385
initial amount: NaN
is: HMDB00292
constant: false
is: CHEBI:17712
type: Species

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_d62efcdc_1781_457f_913f_f2a40636ee69
is encoded by: hsa:3425
initial amount: NaN
type: Species
boundary condition: true
name: IDUA
constant: false
is: SBO:0000252
is: P35475
initial concentration: NaN
has only substance units: false

metaM h l
initial concentration: 1.0
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
type: Species
is: C00080
initial amount: NaN
is: SBO:0000247
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false

metaM fadh2 r
name: FADH2(2-)
is: HMDB01197
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58307
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247

metaR r0647
reactant: MODEL1310110050#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110050#
name: Spontaneous reaction
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
type: Reaction
fast: false

metaR r0475
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110050#
reversible: true

metaM m2gacpail hs r
type: Species
is: SBO:0000247
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
has only substance units: false

metaM 5mthf c
is: HMDB01396
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
type: Species
is: C00440
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:3729
constant: false

metaM ura c
is: HMDB00300
initial concentration: 1.0
is: CHEBI:17568
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: Uracil
is: C00106
constant: false
has only substance units: false

metaM lac D c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: SBO:0000247
name: (R)-lactate
boundary condition: false
is: CHEBI:16004
is: HMDB01311
type: Species
constant: false

metaM dudp n
is: CHEBI:60471
is: SBO:0000247
type: Species
constant: false
boundary condition: false
name: dUDP(3-)
initial amount: NaN
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
has only substance units: false

metaR NMNtn
name: NMN transport, nuclear trhough pore
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction

metaM h m
initial amount: NaN
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: proton
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
is: C00080
constant: false

metaR GLYC3PFADm
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110050#
name: glycerophosphate shuttle for trasnfer of reducing equivalents
kinetic law: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
reversible: false
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_bc25e366_6a1d_48e0_ba50_2dfbacbf2b38
name: ALDH1B1
is: P30837
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:219
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_f75ab013_2fe7_4a7f_b3e3_cdc9029001f8
initial amount: NaN
has only substance units: false
boundary condition: true
name: UROS
is: P10746
is encoded by: hsa:7390
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaM dump c
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
is: C00365
boundary condition: false
is: HMDB01409
initial amount: NaN
name: dUMP
has only substance units: false
initial concentration: 1.0
is: CHEBI:246422
type: Species
constant: false

metaR r0472
reversible: true
is described by: ECO:0000000
product: MODEL1310110050#
fast: false
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_678fa03d_3918_4a82_8c1a_41f54d4ded89
is: SBO:0000252
has only substance units: false
name: _H77542_1_r
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:H77542

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM h n
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: SBO:0000247
name: proton

metaR r2133
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110050#

metaR CYTK10n
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (CMP,dGTP),nuclear
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_bd4b449c_7fd8_44d5_b9e5_fa4157c786c5
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:23236
name: PLCB1
has only substance units: false
boundary condition: true
is: Q9NQ66
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_4d940bfb_080f_43f6_b36d_803057e48c7d
name: LDHD
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:197257
type: Species
is: Q86WU2
is: SBO:0000252
has only substance units: false

metaR RE0383C
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
name: RE0383
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
fast: false
reversible: true

metaM Lkynr c
is: SBO:0000247
is: CHEBI:16946
name: L-kynurenine
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: HMDB00684

metaR CYTDK2m
reactant: MODEL1310110050#
is described by: ECO:0000000
name: cytidine kinase (ATP), mitochondrial
reversible: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false

metaR r1429
name: Free diffusion
fast: false
product: MODEL1310110050#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

metaM acngalgbside hs g
is: SBO:0000247
name: sialyl galactosylgloboside
is: HMDB03406
boundary condition: false
has only substance units: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16523

metaM air c
is: SBO:0000247
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
is: CHEBI:58592
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01235
type: Species
constant: false
initial amount: NaN
is: C03373
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole

metaR ALOX5
reversible: false
modifier: MODEL1310110050#
name: Arachidonate 5-lipoxygenase
is version of: http://identifiers.org/ec-code/1.13.11.34
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe

metaM CE1926 e
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00127
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926

metaM dudp m
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
boundary condition: false
has only substance units: false
is: HMDB01000
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: dUDP(3-)
is: CHEBI:60471

metaM fadh2 m
is: C01352
constant: false
name: Flavin adenine dinucleotide reduced
is: HMDB01197
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM HC02149 m
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
name: O-Propanoylcarnitine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28867
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaR r0051
type: Reaction
reversible: true
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.5
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_1db57b7a_2e77_46f0_a1bd_267d5faaa37a
constant: false
name: DPM2
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:8818
type: Species
initial concentration: NaN
is: SBO:0000252

metaM hretn n
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C20H27O3 CHARGE: -1
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB06254
has only substance units: false
name: 4 hydroxy retinoic acid

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM uri c
initial amount: NaN
has only substance units: false
name: Uridine
initial concentration: 1.0
is: HMDB00296
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: C00299
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704

metaR S6T6g
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
fast: false
is described by: ECO:0000000

metaR r2139
type: Reaction
reversible: true
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#

metaR r1428
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
name: Free diffusion
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_4f9d988f_d57f_4f71_93f4_6eb61d3fdc68
boundary condition: true
is: SBO:0000252
is encoded by: hsa:284273
initial amount: NaN
initial concentration: NaN
name: ZADH2
constant: false
is: Q4G1C4
has only substance units: false
type: Species

metaR GMAND
fast: false
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
type: Reaction
reactant: MODEL1310110050#
modifier: MODEL1310110050#
name: GDP-D-mannose dehydratase
product: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.47

http://identifiers.org/biomodels.db/MODEL1310110050#_68057c06_b7e0_4c91_999f_9d059a863627
boundary condition: true
is: B4DG68
is: SBO:0000252
name: NOS1
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4842

http://identifiers.org/biomodels.db/MODEL1310110050#_e98b9b0a_2503_4958_b78b_6b2c5e943593
has only substance units: false
boundary condition: true
is encoded by: hsa:6526
initial concentration: NaN
is: SBO:0000252
is: P53794
name: SLC5A3
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_14a4224c_9a2c_4338_aa3f_98f2c9878d03
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3033
initial concentration: NaN
is: Q16836
type: Species
name: HADH

http://identifiers.org/biomodels.db/MODEL1310110050#_c6f28b80_2a70_4a59_a323_c0d5e87a6dfc
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2108
initial concentration: NaN
name: ETFA
type: Species
constant: false
is: P13804

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR MANtly
fast: false
product: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000185
name: mannose efflux from lysosome
kinetic law: MODEL1310110050#

metaM thcrm hs g
is: SBO:0000247
type: Species
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
is: CHEBI:24636
initial amount: NaN
has only substance units: false
name: trihexosyl ceramide
constant: false
initial concentration: 1.0
boundary condition: false

metaM uri e
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00296
has only substance units: false
name: Uridine
initial amount: NaN
is: C00299
is: SBO:0000247
is: CHEBI:16704

http://identifiers.org/biomodels.db/MODEL1310110050#_9aa61fb5_2aed_4c42_ad5e_360c438165ac
type: Species
is encoded by: hsa:641372
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ACOT6
has only substance units: false
constant: false
is: Q3I5F7
boundary condition: true

metaM gullac c
initial concentration: 1.0
constant: false
is: CHEBI:17587
boundary condition: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
is: HMDB03466
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: L-gulono-1,4-lactone

metaM glutcoa m
is: SBO:0000247
is: HMDB01339
is: CHEBI:57378
name: glutaryl-CoA(5-)
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial amount: NaN

metaR r2137
reversible: true
type: Reaction
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

http://identifiers.org/biomodels.db/MODEL1310110050#_b3612484_10b6_457f_9548_380aab46185f
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:N63787
name: _N63787_1_c
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_436df169_7a56_4883_9353_34b0bf80d840
type: Species
name: SLC38A5
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q8WUX1
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:92745

http://identifiers.org/biomodels.db/MODEL1310110050#_e21ebc0f_4a7f_4def_bd78_a66bccf684a9
is encoded by: hsa:30
constant: false
is: SBO:0000252
boundary condition: true
name: ACAA1
type: Species
initial amount: NaN
initial concentration: NaN
is: Q96CA6
has only substance units: false

metaR FAOXC2051843m
name: Beta oxidation of fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR INSt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is described by: ECO:0000269
product: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
reversible: true
modifier: MODEL1310110050#
name: Inosine transport (diffusion)
type: Reaction

metaM h r
initial amount: NaN
is: C00080
constant: false
boundary condition: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_25248841_f88d_4a3f_b6a1_3b0e78342797
type: Species
name: HADHB
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:3032
initial concentration: NaN
constant: false
initial amount: NaN
is: P55084

metaR r1872
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_cbdb9eb5_ae78_46a9_961b_1b8358149bc0
boundary condition: true
is encoded by: hsa:2109
is: SBO:0000297
has only substance units: false
type: Species
is encoded by: hsa:2108
constant: false
initial concentration: NaN
name: ETFA:ETFB
has part: P13804
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_86b0b13b_56b7_41c7_b104_ec24bd8f1485
type: Species
initial amount: NaN
is encoded by: hsa:4830
constant: false
is: SBO:0000297
boundary condition: true
name: NME1:NME2
initial concentration: NaN
has only substance units: false

metaM n2m2nmasn e
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false
has only substance units: false
is: C04946
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

http://identifiers.org/biomodels.db/MODEL1310110050#_390cd2a8_d61a_4000_9a1f_e94db5d2f255
is: O76082
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6584
has only substance units: false
type: Species
constant: false
name: SLC22A5
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_1eafad9c_6745_4a56_a9ac_c69bb1ed6620
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: A0PJJ9
is encoded by: hsa:2686
has only substance units: false
name: GGT7

MODEL1310110050
reaction: metaR PSDm hs
reaction: metaR M1316Mg
species: metaM chol n
species: metaM 5fthf c
reaction: metaR PHCDm
reaction: metaR NACHEX3ly
reaction: metaR UAG4E
species: metaM odecoa r
species: metaM dgtp c
species: metaM n2m2nmasn e
reaction: metaR FBA2
reaction: metaR Htr
reaction: metaR r1648
species: metaM succ e
reaction: metaR r0246
reaction: metaR B3GALT42g
reaction: metaR FATP8t
species: metaM lgnc e
species: metaM pydx5p c
reaction: metaR LGNCt
reaction: metaR r0830
species: metaM 3mob e
reaction: metaR PGCD
reaction: metaR EX pnto R LPAREN e RPAREN
reaction: metaR CSPG Btly
species: metaM asp L m
species: metaM tchola e
reaction: metaR MTHFDm
reaction: metaR BACCLm
species: metaM fmn c
reaction: metaR 3AIBTm
species: metaM ps hs m
reaction: metaR r1299
reaction: metaR EX ctp LPAREN e RPAREN
reaction: metaR ADSL1
reaction: metaR r1557
reaction: metaR q10tm
reaction: metaR CO2t
reaction: metaR KYNAKGAT
species: metaM utp c
reaction: metaR EX phyt LPAREN e RPAREN
reaction: metaR r0650
reaction: metaR r2360
reaction: metaR PROSTGE1t
reaction: metaR PI34P5K
species: metaM ile L c
reaction: metaR DM anth
species: metaM prostgh2 c
reaction: metaR EX o2s LPAREN e RPAREN
species: metaM hdca r
species: metaM xan c
species: metaM mescoa m
species: metaM m5masnC g
reaction: metaR AKR1D2
species: metaM dopasf c
species: metaM Rtotal3coa c
species: metaM drib c
reaction: metaR EX ach LPAREN e RPAREN
reaction: metaR r1167
reaction: metaR EX ade LPAREN e RPAREN
species: metaM cs b l
reaction: metaR ESTRADIOLt
reaction: metaR GLRASE
reaction: metaR r0660
reaction: metaR r0960
species: metaM 5forthf c
species: metaM dcdp n
reaction: metaR Rtotaltl
reaction: metaR r0157
species: metaM cs a l
reaction: metaR r2323
reaction: metaR r0779
reaction: metaR EX dopasf LPAREN e RPAREN
species: metaM gdp c
species: metaM glyc S c
reaction: metaR r2388
species: metaM pac c
reaction: metaR GLYt7 311 r
species: metaM anth e
species: metaM nrpphr c

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_761487c5_b480_4254_acff_a8d44b1e7098
is encoded by: hsa:5277
constant: false
has part: B2RAU6
has part: P57054
type: Species
is encoded by: hsa:9091
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
is encoded by: hsa:51227
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:5279
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_656f0211_4a5b_42d3_9f74_19cf43b8010f
has only substance units: false
is: SBO:0000252
name: PIP4K2C
initial amount: NaN
constant: false
is: B3KQV3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:79837
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_ca95116d_ff9c_4381_a82e_3ba021e1b9cb
name: ACO2
initial amount: NaN
has only substance units: false
is encoded by: hsa:50
is: SBO:0000252
is: Q99798
initial concentration: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_bc874041_6105_4737_9769_3864393cd58f
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: P54750
is encoded by: hsa:5136
initial amount: NaN
boundary condition: true
name: PDE1A

metaM ksi pre12 g
boundary condition: false
is: HMDB06552
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 12
has only substance units: false
initial concentration: 1.0
is: CHEBI:2504
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
initial amount: NaN
constant: false
type: Species

metaR MTHFCm
is version of: http://identifiers.org/ec-code/6.3.4.3
modifier: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_f039d8df_b3ce_41bd_acc8_5d3fa391b6fb
is: SBO:0000252
type: Species
initial concentration: NaN
is: O95992
boundary condition: true
is encoded by: hsa:9023
has only substance units: false
constant: false
initial amount: NaN
name: CH25H

metaM cs b l
constant: false
type: Species
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
boundary condition: false
has only substance units: false
is: CHEBI:36005
initial amount: NaN
initial concentration: 1.0
is: HMDB02183
is: SBO:0000247

metaM bilglcur r
is: CHEBI:57767
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_ec7c28cd_81bf_429e_9fa2_d02be517cfb2
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1350
initial amount: NaN
is: P15954
name: COX7C

metaM cholcoa x
is: HMDB01374
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57373
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)

metaM apoC c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: XH CHARGE: 0
is: CHEBI:33190
constant: false
has only substance units: false
name: Apocarboxlase (no lys residue)
is: HMDB11111
type: Species

metaR S4TASE3ly
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false

metaM Rtotal c
type: Species
notes: FORMULA: CO2FULLR CHARGE: -1
is: HMDB01448
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:16189
initial amount: NaN
boundary condition: false
name: R total

metaR FAOXC1811601m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110050#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM uacgam g
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00290
has only substance units: false
is: CHEBI:57705

metaR S6T8g
is: SBO:0000176
reversible: false
modifier: MODEL1310110050#
fast: false
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaR B3GALT43g
name: Beta-1,3-galactosyltransferase 4
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.62
product: MODEL1310110050#
is described by: ECO:0000269
modifier: MODEL1310110050#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f9da07da_71fd_4dc8_be8a_1674c5abf4c4
has only substance units: false
constant: false
boundary condition: true
is: Q6IA69
type: Species
is encoded by: hsa:55191
initial concentration: NaN
is: SBO:0000252
name: NADSYN1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_330e962e_3003_43ab_a9f1_e5cd6a4d5e86
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM tymsf e
name: Tyramine O-sulfate
constant: false
is: SBO:0000247
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial amount: NaN
is: HMDB06409
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

metaM pail45p hs m
is: SBO:0000247
has only substance units: false
is: CHEBI:28910
constant: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaR SEBCOAPET
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_c316d109_016b_48f2_b8c6_93a5275ba23e
is: B4DGD7
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3423
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: IDS
type: Species

metaR FATP8t
product: MODEL1310110050#
name: fatty acid electroneutral transport
is described by: ECO:0000269
fast: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.7

http://identifiers.org/biomodels.db/MODEL1310110050#_ec63e19f_9910_4f1e_85e2_371b77c240ab
is encoded by: hsa:R06874
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: _R06874_1_r
has only substance units: false
initial amount: NaN

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_b411a642_2f4d_49db_9dd2_4f67dd86ef90
is: SBO:0000252
type: Species
has only substance units: false
is: Q5MY95
is encoded by: hsa:377841
initial amount: NaN
name: ENTPD8
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f57d19d5_63cd_4d20_b098_ee31cb413f5e
type: Species
constant: false
is encoded by: hsa:93183
boundary condition: true
name: PIGM
is: Q9H3S5
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR SBT Dtde
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000134
name: D-sorbitol transport, extracellular
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

http://identifiers.org/biomodels.db/MODEL1310110050#_3ea71244_534f_43d6_a6d4_1e3d02aa0720
name: SULT1A2
type: Species
boundary condition: true
constant: false
is: P50226
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6799
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_75aa2a15_ae14_4683_9c17_f6b40c402c57
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q7Z7B1
name: PIGW
type: Species
is encoded by: hsa:284098

metaR r0633
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_e8a6d363_4b58_4a06_856c_de058248b635
boundary condition: true
has only substance units: false
is encoded by: hsa:4709
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q6IB80
name: NDUFB3

metaR MM8Cg
reversible: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110050#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_b55e4d08_0dc5_49c6_8d03_4929f633a181
type: Species
is: B2RAU6
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9091
name: PIGQ

http://identifiers.org/biomodels.db/MODEL1310110050#_eb3d2b01_2692_4900_b0f7_d110ab01e52d
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6241
initial amount: NaN
is: P31350
initial concentration: NaN
name: RRM2

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_796ee6c1_0234_45a3_ad83_dd35bf67a1a0
has only substance units: false
name: FDFT1
is encoded by: hsa:2222
boundary condition: true
type: Species
is: P37268
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM ksi pre4 g
is: SBO:0000247
is: HMDB06552
has only substance units: false
boundary condition: false
is: CHEBI:2504
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 4
notes: FORMULA: C101H165N7O72X CHARGE: -1
constant: false
initial concentration: 1.0
type: Species

metaM gthrd c
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: HMDB00125
boundary condition: false
constant: false
is: C00051
initial concentration: 1.0
name: Reduced glutathione
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_1b1bba7d_daf0_4c01_8109_53a3e63913dc
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: ABCD1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:215
is: P33897
boundary condition: true

metaR G3PD1
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.8
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
name: glycerol-3-phosphate dehydrogenase (NAD)
reversible: true
type: Reaction
reactant: MODEL1310110050#

metaM sphings l
boundary condition: false
name: sphingosine(1+)
constant: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: SBO:0000247
is: CHEBI:57756
initial concentration: 1.0
is: HMDB00252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_74ca61e6_fb45_4a06_a93d_fac48af880ba
is encoded by: hsa:8435
name: SOAT2
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: O75908

http://identifiers.org/biomodels.db/MODEL1310110050#_c401a87d_9d9b_48ee_9aeb_25611d110b1e
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5464
name: PPA1
is: Q15181
constant: false
is: SBO:0000252

metaM idp n
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
initial amount: NaN
name: IDP(3-)
initial concentration: 1.0
is: CHEBI:58280
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM 34dhmald c
type: Species
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
is: HMDB06242
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
initial concentration: 1.0
is: C05577
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_44574798_a6ef_408f_9ec3_c39299622705
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI620219
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: _AI620219_1_e

metaR FPGS7m
reversible: false
product: MODEL1310110050#
name: folylpolyglutamate synthetase (10fthf), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.17
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT

metaR HSAT4ly
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_86843d78_daf4_4093_b9c0_bab4bd8f2322
initial amount: NaN
name: _AA977580_1_c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA977580
has only substance units: false
type: Species
constant: false
boundary condition: true

metaM didp c
has only substance units: false
name: dIDP
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB03536
type: Species
is: CHEBI:28823
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_3eae0dfd_726b_41d0_bf1c_9ee474901c87
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:1716
is: E5KSL6
name: DGUOK
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_30b260c9_4b31_455a_9774_4984184a6d30
constant: false
type: Species
name: ATP10A
is: SBO:0000252
is encoded by: hsa:57194
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O60312
has only substance units: false

metaM dhf c
is: HMDB01056
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
is: SBO:0000247
is: CHEBI:57451
is: C00415
has only substance units: false
name: 7,8-Dihydrofolate

metaR r2079
reversible: true
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000000

metaR r0494
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
fast: false
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#

metaR r0630
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
is described by: ECO:0000000
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#

metaM 2oxoadp m
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: HMDB00225
name: 2-oxoadipate(2-)
type: Species
is: CHEBI:57499
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_b12d2909_6dc7_4106_9363_b3322948591b
is encoded by: hsa:427
is: Q96AS2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
name: ASAH1

metaM CE5236 n
constant: false
has only substance units: false
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
is: HMDB03952
is: CHEBI:28002
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false
initial concentration: 1.0

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM ptth c
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB03426
has only substance units: false
name: pantetheine
constant: false
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM 3mob m
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00019

metaM fn2m2masn g
initial concentration: 1.0
is: CHEBI:32984
boundary condition: false
constant: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine

metaR r0384
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false

metaR RE1448N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
name: RE1448
is: SBO:0000176

metaM cytd m
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
is: HMDB00089
constant: false
is: CHEBI:17562
name: cytidine
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR GARFT
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110050#
name: phosphoribosylglycinamide formyltransferase
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
reversible: true
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.1.2.2
is: SBO:0000176

metaM taur e
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
has only substance units: false
type: Species
is: C00245
is: SBO:0000247
is: CHEBI:3544
initial concentration: 1.0
name: Taurine
initial amount: NaN
constant: false
boundary condition: false

metaM 3mox4hoxm c
is: CHEBI:27622
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
name: 3-Methoxy-4-hydroxymandelate
is: HMDB00291
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_d65ddcc7_9519_46ee_8cfe_583a6edd0a56
constant: false
name: GALNS
has only substance units: false
initial amount: NaN
is: P34059
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2588
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_27c8aaae_04c8_48cb_b19e_9308b86990bc
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:80025
is: Q6P1K9
is: SBO:0000252
has only substance units: false
name: PANK2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_d3ac4ec2_ec39_438d_8537_aaf16fe263c2
boundary condition: true
is encoded by: hsa:BG035985
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: _BG035985_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_5cfbf50b_e93c_4019_ada0_78d7bec3385e
is encoded by: hsa:5296
initial amount: NaN
type: Species
boundary condition: true
is: O00459
constant: false
is: SBO:0000252
has only substance units: false
name: PIK3R2
initial concentration: NaN

metaR r0741
kinetic law: MODEL1310110050#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
fast: false
type: Reaction
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110050#
reversible: true

metaM ptdcacoa m
type: Species
boundary condition: false
constant: false
is: HMDB06499
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: pentadecanoyl Coenzyme A

metaM n2m2nmasn l
notes: FORMULA: C58H96N5O40X CHARGE: 0
has only substance units: false
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: C04946
is: SBO:0000247
initial amount: NaN
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

http://identifiers.org/biomodels.db/MODEL1310110050#_5f4bcc6f_4009_4ddf_a7de_50ef328e7ed0
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI024818
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: _AI024818_1_c

metaM 34dhmald m
has only substance units: false
name: 3,4-Dihydroxymandelaldehyde
is: SBO:0000247
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false
is: HMDB06242
initial concentration: 1.0
is: C05577
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7903
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_c136bc93_4c99_4d64_932c_6722412eb8e2
is encoded by: hsa:2348
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: FOLR1

metaM ppp9 m
is: CHEBI:36159
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00241
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
name: Protoporphyrin
has only substance units: false
is: SBO:0000247

metaM ptth e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16753
name: pantetheine
boundary condition: false
has only substance units: false
is: HMDB03426
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_449399a8_0c58_4c8c_af7c_2b518aa47b7d
is: O14832
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5264
name: PHYH

metaR S2TASE3ly
reversible: false
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: iduronate-2-sulfatase, lysosomal
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_ceb771fd_8462_4f34_976e_09b1c763d4d7
constant: false
is encoded by: hsa:AI469183
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: _AI469183_1_x

http://identifiers.org/biomodels.db/MODEL1310110050#_7f5e2565_ea9a_4458_ab3a_51069d57a265
is: P49247
name: RPIA
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:22934
constant: false
type: Species
has only substance units: false

metaM C04849 e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57449

http://identifiers.org/biomodels.db/MODEL1310110050#_5c2de660_5406_4bfc_a254_0f16bc5de01a
is: P35754
is: SBO:0000252
constant: false
name: GLRX
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:2745
has only substance units: false

metaR XOLEST2te
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000185
name: cholesterol ester transporter
fast: false

metaR r1167
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
fast: false
product: MODEL1310110050#
name: EC:2.3.1.26
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_a7ba60be_449a_4df7_af42_2d426c8ecc02
type: Species
boundary condition: true
is encoded by: hsa:3030
initial concentration: NaN
is: SBO:0000252
name: HADHA
constant: false
has only substance units: false
is: E9KL44
initial amount: NaN

metaR CPPPGO
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.3.3
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000304
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
type: Reaction
name: coproporphyrinogen oxidase (O2 required)

metaR LEUKTRE4t
fast: false
is: SBO:0000185
name: leukotriene E4 transport
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

metaM ncam c
is: CHEBI:0
initial concentration: 1.0
is: HMDB01406
notes: FORMULA: C6H6N2O CHARGE: 0
is: C00153
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: Nicotinamide
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_ec8a75f9_cdb6_4c77_a98d_0b762e8e885a
initial amount: NaN
constant: false
name: AK7
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q96M32
has only substance units: false
type: Species
is encoded by: hsa:122481

http://identifiers.org/biomodels.db/MODEL1310110050#_cbdb8cb7_ac79_4c87_982a_7487a2865bf8
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27068
constant: false
name: PPA2
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_6aa3fe3b_0b57_4e72_8eae_3e729e5d5524
boundary condition: true
is: Q9Y6L6
name: SLCO1B1
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:10599
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM lthstrl r
initial concentration: 1.0
name: 5alpha-cholest-7-en-3beta-ol
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
type: Species
has only substance units: false
constant: false
is: CHEBI:17168
is: HMDB01170
boundary condition: false

metaM gullac r
type: Species
name: L-gulono-1,4-lactone
constant: false
is: HMDB03466
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17587
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
has only substance units: false

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaR RE3347C
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
name: RE3347

metaM taur c
is: HMDB00251
has only substance units: false
type: Species
is: C00245
name: Taurine
initial concentration: 1.0
is: CHEBI:3544
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false

metaM gthrd e
initial concentration: 1.0
type: Species
is: HMDB00125
name: glutathionate(1-)
initial amount: NaN
has only substance units: false
is: CHEBI:57925
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false

metaR GLNLASEer
type: Reaction
reversible: true
product: MODEL1310110050#
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is described by: ECO:0000000
name: gluconolactonase, endoplasmic reticulum

metaR NACASPtm
is described by: ECO:0000000
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
type: Reaction
fast: false
product: MODEL1310110050#
is: SBO:0000185
reversible: false

metaR r0385
product: MODEL1310110050#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_911653e0_3a90_4484_a414_9af52a816e24
boundary condition: true
constant: false
is: SBO:0000252
name: ESCO1
is: Q5FWF5
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:114799

metaR ACITL
reactant: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.3.8
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: ATP-Citrate lyase
reversible: false
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
modifier: MODEL1310110050#

metaR H2O2tm
kinetic law: MODEL1310110050#
is described by: ECO:0000000
name: hydrogen peroxide mitochondrial transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
product: MODEL1310110050#
reversible: true
fast: false
reactant: MODEL1310110050#

metaR HMBS
fast: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.5.1.61
name: hydroxymethylbilane synthase
reversible: false
is: SBO:0000176
product: MODEL1310110050#
is described by: ECO:0000254
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
kinetic law: MODEL1310110050#

metaR DURAD2
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
name: dihydrothymin dehydrogenase (NADP)
product: MODEL1310110050#

metaM adpcoa c
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: adipoylcoa
is: C14143
is: SBO:0000247
is: HMDB04047
constant: false

metaR NDPK10n
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reversible: true
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM retinol cis 11 c
is: CHEBI:16302
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB06216
name: 11-cis-retinol
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_90a1db64_ded9_46f0_850c_a33248ba1ee3
is: Q9UNA3
is encoded by: hsa:51146
initial amount: NaN
boundary condition: true
name: A4GNT
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_94de9e1e_8edf_4a05_89b3_808a2ae74852
is encoded by: hsa:5167
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: P22413
name: ENPP1
initial concentration: NaN

metaM pail45p hs n
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28910
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate

http://identifiers.org/biomodels.db/MODEL1310110050#_ebd96a66_089d_4f94_8759_750ab2bba13b
is: P33908
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: MAN1A1
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4121

metaM tyr L c
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17895
has only substance units: false
constant: false
is: HMDB00158
initial concentration: 1.0
name: L-tyrosine
initial amount: NaN

metaR PHYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_4451c51a_73a6_424f_b2ce_2954a38975a8
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:64841
has only substance units: false
initial amount: NaN
boundary condition: true
name: GNPNAT1
constant: false
is: Q96EK6

metaM ddeccrn c
is: HMDB02250
name: lauroyl carnitine
notes: FORMULA: C19H37NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

metaR RPEc
is: SBO:0000176
kinetic law: MODEL1310110050#
name: ribulose 5-phosphate 3-epimerase
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reversible: true
fast: false
is described by: ECO:0000134
type: Reaction

metaR C81CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaR 3HCO3 NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reactant: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
fast: false
name: 3HCO3_NAt
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110050#

metaR r2359
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_d46f34f4_6534_4a70_be67_3177dc0b910e
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P54819
is encoded by: hsa:204
constant: false
has only substance units: false
name: AK2
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_9efafaf8_e200_4450_8ade_9991facad297
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:6888
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P37837
constant: false
name: TALDO1

http://identifiers.org/biomodels.db/MODEL1310110050#_e0106df5_707a_43b8_9dec_1d59f09b27ca
constant: false
is: Q8IXK2
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: GALNT12
is encoded by: hsa:79695

metaM tyr L e
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
constant: false
is: CHEBI:17895
is: HMDB00158
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: L-tyrosine

metaR r0381
type: Reaction
reactant: MODEL1310110050#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
kinetic law: MODEL1310110050#
is: SBO:0000176
reversible: true
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
is described by: ECO:0000000
fast: false

metaR PIACGT
is described by: ECO:0000000
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.83
product: MODEL1310110050#
name: phosphatidylinositol N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.198
fast: false
is: SBO:0000176
modifier: MODEL1310110050#
reversible: false
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…

metaR RE1901R
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000000
name: RE1901
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
is: SBO:0000176
product: MODEL1310110050#

metaR FAOXC15NADx
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nad)x
type: Reaction

metaR GGT6
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
name: Gamma-glutamyltransferase
is: SBO:0000176
product: MODEL1310110050#

metaM 12ppd R c
has only substance units: false
initial concentration: 1.0
name: (R)-propane-1,2-diol
is: CHEBI:28972
is: HMDB01881
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
constant: false
type: Species
is: SBO:0000247

metaR r1871
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: false
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#

metaM ptth m
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB03426
is: CHEBI:16753
type: Species
name: pantetheine
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_2fc58214_cbc2_446b_ac3e_e0dca10c5081
is: P12235
initial amount: NaN
name: SLC25A4
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:291
has only substance units: false
type: Species

metaR r0940
name: Free diffusion
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000185

metaM dhf m
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: dihydrofolate(2-)
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
has only substance units: false
is: CHEBI:57451
is: HMDB01056

metaM bildglcur r
type: Species
initial concentration: 1.0
has only substance units: false
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
initial amount: NaN
is: HMDB03325
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_50fc8104_0be7_4baf_ad5d_0e14d7ae7d34
initial amount: NaN
is: Q9NRR6
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56623
is: SBO:0000252
name: INPP5E

metaR TRDR
type: Reaction
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110050#
name: thioredoxin reductase (NADPH)
fast: false
kinetic law: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.8.1.9

metaM 56dura c
type: Species
is: HMDB00076
initial amount: NaN
has only substance units: false
name: 5,6-dihydrouracil
is: CHEBI:15901
is: SBO:0000247
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
constant: false
boundary condition: false
initial concentration: 1.0

metaR GD1Cte
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: true
name: gd1c hs transport

metaM HC01118 r
initial amount: NaN
is: CHEBI:57310
name: presqualene diphosphate(3-)
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
boundary condition: false

metaM CE2417 m
type: Species
initial concentration: 1.0
is: HMDB11123
is: SBO:0000247
is: CHEBI:28387
initial amount: NaN
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
has only substance units: false
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_56395faf_98c8_4ab7_8e5d_bf780d583563
has only substance units: false
name: PIGF:PIGO
has part: Q6IB04
is encoded by: hsa:84720
constant: false
type: Species
is encoded by: hsa:5281
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000297

metaR HISCAT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR r2369
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR GLUTCOAACBP
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_369df7a2_3cfb_4a19_b504_cf4c7ba6705c
name: PRDX2
boundary condition: true
is encoded by: hsa:7001
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaR r0310
kinetic law: MODEL1310110050#
product: MODEL1310110050#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
reactant: MODEL1310110050#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction

metaM CE2435 m
is: CHEBI:57795
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: SBO:0000247
type: Species
initial amount: NaN
name: trans,cis-deca-2,4-dienoyl-CoA
has only substance units: false
constant: false

metaM CE5236 c
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
constant: false
is: CHEBI:28002
boundary condition: false
is: HMDB03952
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin

metaM cs a l
constant: false
is: SBO:0000247
is: HMDB02183
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial amount: NaN
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
boundary condition: false
is: CHEBI:36005
initial concentration: 1.0
has only substance units: false

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR PRODt2r
reversible: true
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
is described by: ECO:0000304
modifier: MODEL1310110050#
name: D-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
fast: false
type: Reaction

metaR ST8SIA55g
kinetic law: MODEL1310110050#
reversible: false
type: Reaction
modifier: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
name: Beta-galactoside alpha-2,3-sialyltransferase
product: MODEL1310110050#
is: SBO:0000176
fast: false

metaM cytd e
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:17562
constant: false
initial amount: NaN
name: Cytidine
is: C00475
is: HMDB00089
initial concentration: 1.0

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM gthrd m
initial amount: NaN
is: HMDB00125
boundary condition: false
constant: false
name: glutathionate(1-)
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
is: CHEBI:57925
type: Species
has only substance units: false
initial concentration: 1.0

metaR r0747
fast: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#

metaR r2368
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaR r0202
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110050#
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110050#

metaM glu L m
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: L-glutamate(1-)
is: SBO:0000247
type: Species
is: CHEBI:29985
has only substance units: false
is: HMDB00148

metaR ACCOAtn
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
name: acetyl-CoA transport, nuclear
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_1b506b22_99dd_4a9c_8222_2e75e44b5466
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:171425
name: CLYBL
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_37024c31_7a44_4895_824a_745063df01a0
initial amount: NaN
is: P55084
type: Species
has only substance units: false
is encoded by: hsa:3032
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: HADHB

metaR PNTEH
type: Reaction
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
reversible: false
name: Hydrolase Class ( RXN R02973)
is version of: http://identifiers.org/ec-code/3.5.1.92
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110050#

metaM xol7ah2 m
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
constant: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial amount: NaN
is: CHEBI:28047
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_16a6a49e_23b4_4438_8b97_ad3969947e00
initial concentration: NaN
is: O00764
boundary condition: true
name: PDXK
is encoded by: hsa:8566
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR r2140
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110050#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110050#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_4c04ae86_b34c_4591_9f67_9dbfa14d3486
type: Species
is: SBO:0000252
initial concentration: NaN
name: ITPKA
is encoded by: hsa:3706
initial amount: NaN
constant: false
boundary condition: true
is: P23677
has only substance units: false

metaM HC01405 m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: (S)-Hydroxyoctanoyl-CoA
is: CHEBI:28632
type: Species
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266

metaR EX debrisoquine LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: debrisoquine exchange
type: Reaction

metaR SUCCtp
reactant: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
name: succinate transporter, peroxisome

metaR GD1Ctg
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000185
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
type: Reaction
reversible: true
product: MODEL1310110050#
name: gd1c hs intracellular transport

metaR r2367
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_f8140ab6_564d_457a_abbd_ceb11d6a31ef
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: HSD17B4
is encoded by: hsa:3295
is: E9PB82
constant: false
boundary condition: true
initial amount: NaN

metaR EX 5fthf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-Formyltetrahydrofolate exchange
type: Reaction

metaM prostgd2 e
is: HMDB01403
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57406
name: prostaglandin D2(1-)

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110050#
reversible: true
type: Reaction
product: MODEL1310110050#
name: PTPATe
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000134
fast: false

metaM leuktrC4 e
name: leukotriene C4(2-)
type: Species
constant: false
is: CHEBI:57973
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: HMDB01198
initial amount: NaN

metaM cytd c
is: HMDB00089
type: Species
has only substance units: false
boundary condition: false
name: Cytidine
is: SBO:0000247
is: C00475
is: CHEBI:17562
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

metaM cholcoa c
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: choloyl-CoA(4-)
is: CHEBI:57373
is: HMDB01374
is: SBO:0000247
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_8b77c4cd_bdd1_475a_af8a_a0608957e0bd
has only substance units: false
initial amount: NaN
name: SLC27A2
is: O14975
constant: false
is encoded by: hsa:11001
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_62c52c45_62f3_4585_a665_4ba2b057b2e5
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:386757
initial amount: NaN
has only substance units: false
constant: false
name: SLC6A10P
boundary condition: true

metaR r0944
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
name: Active transport
product: MODEL1310110050#
reactant: MODEL1310110050#

metaM ksi pre8 g
name: keratan sulfate I biosynthesis, precursor 8
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
is: CHEBI:28067
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C115H186N8O88S2X CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110050#_412494c2_e493_4e1d_9deb_15735bc6f896
constant: false
name: PTGDS
is: SBO:0000252
is encoded by: hsa:5730
initial concentration: NaN
boundary condition: true
is: P41222
type: Species
initial amount: NaN
has only substance units: false

metaR r2366
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
is: SBO:0000185
product: MODEL1310110050#
fast: false

metaR r0208
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.4.1.1
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13

http://identifiers.org/biomodels.db/MODEL1310110050#_3d34c673_885d_4f2f_8b18_0245292e163a
has only substance units: false
type: Species
name: SDHA
constant: false
is: P31040
boundary condition: true
is encoded by: hsa:6389
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r2142
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110050#
reversible: true
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_155740b0_08f3_42f0_8473_2848bd908897
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:220
has only substance units: false
type: Species
constant: false
is: P47895
name: ALDH1A3

metaR FAOXC12DCc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_c69e4fdf_0f08_4e56_9919_64670fcfb5ea
is: O15121
initial amount: NaN
constant: false
boundary condition: true
name: DEGS1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:8560

metaM pa hs m
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
initial concentration: 1.0
is: SBO:0000247
name: phosphatidate(2-)
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaM glu L l
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:29985
is: HMDB00148
has only substance units: false
type: Species

metaR r2365
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
reversible: true
name: Organic anion transporter 5 Utilized transport

metaM prostgd2 c
type: Species
initial amount: NaN
is: HMDB01403
name: prostaglandin D2(1-)
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaR ARACHDCOAtx
is: SBO:0000185
kinetic law: MODEL1310110050#
fast: false
name: fatty acid intracellular transport
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reversible: true

metaM 3hmbcoa m
is: HMDB01356
has only substance units: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57312
is: SBO:0000247
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
boundary condition: false

metaR SBTR
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110050#
type: Reaction
name: D-sorbitol reductase
reversible: false

metaR r2141
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_c075e574_a68a_406d_8ba2_9cc14c612bf0
is encoded by: hsa:79611
name: ACSS3
is: Q9H6R3
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_633a0829_5dd9_4b20_baff_dddf5042da5e
is: B3KT86
initial amount: NaN
type: Species
is encoded by: hsa:109
name: ADCY3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR r2364
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#

metaR r0942
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
kinetic law: MODEL1310110050#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_86f9f139_37e9_481c_87e3_629625a8de0e
is encoded by: hsa:56922
is encoded by: hsa:64087
name: MCCC1:MCCC2
initial concentration: NaN
has only substance units: false
is: SBO:0000297
constant: false
has part: Q96RQ3
boundary condition: true
initial amount: NaN
type: Species
has part: Q9HCC0

http://identifiers.org/biomodels.db/MODEL1310110050#_5d2446fb_c538_467e_90ba_7f673fd07813
initial amount: NaN
constant: false
name: FASN
boundary condition: true
type: Species
is encoded by: hsa:2194
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P49327

metaR r0743
is: SBO:0000176
reactant: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR ACCOAtr
reversible: true
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: acetyl-coa transport
modifier: MODEL1310110050#

metaM cs e deg5 l
is: CHEBI:57737
is: SBO:0000247
notes: FORMULA: C31H47NO35S3 CHARGE: -4
type: Species
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00868
boundary condition: false

metaM hmgcoa x
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false
boundary condition: false
type: Species
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15467

metaM nm4masn g
notes: FORMULA: C54H90N3O40X CHARGE: 0
has only substance units: false
constant: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C05882
type: Species

metaR C121CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR r0377
reversible: false
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reactant: MODEL1310110050#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110050#

metaM eaflatoxin e
is: CHEBI:30725
type: Species
has only substance units: false
is: HMDB06558
boundary condition: false
name: aflatoxin B1 exo-8,9-epoxide
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C17H12O7 CHARGE: 0 INCHI: InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_25827c33_4edb_424b_90cc_d3a035254057
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: CYP8B1
has only substance units: false
constant: false
type: Species
is encoded by: hsa:1582
is: Q9UNU6
is: SBO:0000252

metaR HPYRR2x
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
modifier: MODEL1310110050#
is: SBO:0000176
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.2.4
name: hydroxypyruvate reductase (NADH)
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false

metaR EX cspg d LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_c7d24fcb_fe7b_471f_9e65_1fa4ac36af09
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3795
name: KHK
is: P50053
constant: false
type: Species

metaM HC01401 x
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial amount: NaN
is: CHEBI:27668
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_37f44a85_59d7_42da_a55b_3b696141342c
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80308
has only substance units: false
name: FLAD1
constant: false

metaR r2363
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#

metaR DHORD9
modifier: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.5.2
kinetic law: MODEL1310110050#
name: dihydoorotic acid dehydrogenase (quinone10)
reversible: false
is: SBO:0000185
reactant: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
fast: false

metaR r0744
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reversible: false
is: SBO:0000176
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107

metaR r0941
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
fast: false
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: true
name: Free diffusion
is described by: ECO:0000000
product: MODEL1310110050#

metaR XOL27OHtm
reactant: MODEL1310110050#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: 27 hydroxy cholesterol transport

metaR H6ET3er
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.8.1
reversible: false
type: Reaction

metaM ptdcacoa c
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
constant: false
is: HMDB06499
name: pentadecanoyl Coenzyme A
initial amount: NaN

metaR r2362
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaM onpthl c
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06215
name: naphthalene epoxide
boundary condition: false
constant: false
notes: FORMULA: C10H8O CHARGE: 0 INCHI: InChI=1/C10H8O/c1-2-4-8-7(3-1)5-6-9-10(8)11-9/h1-6,9-10H
has only substance units: false
initial concentration: 1.0

metaR NADtn
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
name: NAD transport, nuclear through pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_8ec3201d_0fc5_4341_af6c_eaac2c608e62
name: SLC34A2
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:10568
constant: false
is: O95436
is: SBO:0000252
has only substance units: false

metaR r1013
reactant: MODEL1310110050#
fast: false
name: Transport reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
is: SBO:0000185

metaM Rtotal l
notes: FORMULA: CO2FULLR CHARGE: -1
has only substance units: false
is: SBO:0000247
name: R total
type: Species
boundary condition: false
is: CHEBI:52639
initial concentration: 1.0
initial amount: NaN
constant: false

metaM 3ddcrn c
constant: false
boundary condition: false
has only substance units: false
is: HMDB00623
initial amount: NaN
name: 3-hydroxydodecanoylcarnitine
type: Species
notes: FORMULA: C19H37NO5 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0

metaR r0317
reversible: true
is: SBO:0000176
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
product: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4

http://identifiers.org/biomodels.db/MODEL1310110050#_dfae065c_b312_4dd0_9b96_78d90ff6099f
is encoded by: hsa:4357
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: MPST
is: P25325
initial concentration: NaN
is: SBO:0000252

metaM dhf e
has only substance units: false
is: SBO:0000247
name: dihydrofolate(2-)
boundary condition: false
is: CHEBI:57451
constant: false
is: HMDB01056
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaM hs deg15 l
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:16126
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 15
notes: FORMULA: C49H71N2O57S5 CHARGE: -7

metaR NACASPAH
name: N-Acetyl-L-aspartate amidohydrolase
is version of: http://identifiers.org/ec-code/3.5.1.15
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110050#

metaR r2361
fast: false
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR NACHEXA4ly
is: SBO:0000176
fast: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110050#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#

metaR FAEL183
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is: SBO:0000176
fast: false
product: MODEL1310110050#
reversible: false
type: Reaction
is described by: ECO:0000000
name: fatty-acyl-CoA elongation (n-C18:3CoA)

http://identifiers.org/biomodels.db/MODEL1310110050#_543b5a51_ea66_4461_a182_080b6d4e98b7
is encoded by: hsa:5373
is: O15305
name: PMM2
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR CYTK3n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110050#
is: SBO:0000176
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaR r1012
kinetic law: MODEL1310110050#
name: Postulated transport reaction
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
reversible: false
is: SBO:0000185
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_3a9050e2_9989_499f_92a5_6b4f1edf3b55
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: MGAT2
constant: false
is encoded by: hsa:4247
initial concentration: NaN
is: SBO:0000252
is: Q10469

http://identifiers.org/biomodels.db/MODEL1310110050#_28adeee4_4916_499a_8b51_a1c5c78282ed
constant: false
is: SBO:0000252
is encoded by: hsa:80864
has only substance units: false
boundary condition: true
name: EGFL8
is: Q99944
type: Species
initial concentration: NaN
initial amount: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR 4ABUTtm
fast: false
kinetic law: MODEL1310110050#
reversible: true
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
name: 4-aminobutanoate mitochondrial transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_3b3159af_84c5_42dc_be94_c8a13ab6a6df
type: Species
is: P78356
is: SBO:0000252
is encoded by: hsa:8396
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PIP4K2B

metaM ksi pre22 g
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 22
is: CHEBI:2504
initial amount: NaN
is: HMDB06552

http://identifiers.org/biomodels.db/MODEL1310110050#_c9c89909_6f3d_407c_bcf2_ff9b30d3e57c
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110050#_d6af404b_cda4_4413_ba0c_cc16aa5ba8d6
constant: false
boundary condition: true
has only substance units: false
name: GOT2
is: SBO:0000252
type: Species
is encoded by: hsa:2806
initial amount: NaN
initial concentration: NaN
is: P00505

metaR UMPK2n
reactant: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
name: UMP kinase (CTP),nuclear
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110050#
is: SBO:0000176

metaR HISTAtu
reactant: MODEL1310110050#
reversible: true
name: Histamine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110050#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000269

metaR r2360
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaR FAOXC226205m
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
name: Beta oxidation of long chain fatty acid
reversible: false
product: MODEL1310110050#
modifier: MODEL1310110050#

metaM Ser Gly Ala X Gly l
is: CHEBI:36005
is: HMDB02183
notes: FORMULA: XH CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: protein-linked serine residue (glycosaminoglycan attachment site)

metaR EX hcoumarin LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxy coumarin exchange
type: Reaction

metaR SADT
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
is described by: ECO:0000269
fast: false

metaM adrncrn m
boundary condition: false
constant: false
name: Adrenyl carnitine
type: Species
is: HMDB00062
notes: FORMULA: C29H49NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
is: C00318
is: CHEBI:16347
initial concentration: 1.0
is: SBO:0000247

metaR CYSGLTH
reversible: true
fast: false
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is described by: ECO:0000000
name: Glutathione:cystine oxidoreductase
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaM 3ddcrn e
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C02838
initial amount: NaN
constant: false
name: 3-hydroxydodecanoylcarnitine
notes: FORMULA: C19H37NO5 CHARGE: 0
is: HMDB00791
boundary condition: false

metaR LACZe
kinetic law: MODEL1310110050#
is described by: ECO:0000134
modifier: MODEL1310110050#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.108
fast: false
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
reversible: false
product: MODEL1310110050#
reactant: MODEL1310110050#
name: b-galactosidase, extracellular

metaR r0946
reversible: true
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110050#

metaM pail345p hs c
constant: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57836
initial concentration: 1.0
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)

metaR r0634
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#

metaM pa hs n
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
constant: false
type: Species

metaR PPCOAOm
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110050#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110050#
type: Reaction
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD

metaM sucsal m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
name: Succinic semialdehyde
initial amount: NaN
is: HMDB01259
boundary condition: false
is: CHEBI:57706
type: Species
has only substance units: false
constant: false

metaR r1014
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: Postulated transport reaction
reactant: MODEL1310110050#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
type: Reaction

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM xol27oh r
has only substance units: false
type: Species
name: 26-hydroxycholesterol
initial concentration: 1.0
boundary condition: false
is: HMDB02103
initial amount: NaN
is: CHEBI:17703
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false

metaR GTHPm
is: SBO:0000176
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.15
type: Reaction
is described by: ECO:0000269
name: glutathione peroxidase, mitochondria
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#

metaR BILGLCURtr
is described by: ECO:0000000
product: MODEL1310110050#
name: glucuronidated compound transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_823fc77c_496a_4329_b115_d5c7368f1bf9
constant: false
boundary condition: true
is: SBO:0000252
name: HIBCH
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:26275
initial amount: NaN
is: Q6NVY1

metaR DHAPtc
kinetic law: MODEL1310110050#
reversible: false
name: transport of DHAP into cytosol
is described by: ECO:0000134
type: Reaction
fast: false
product: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR FE2tm
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
name: iron (II) transport
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_7fed4132_bfd1_49b0_968d_697a1ad2dfc6
is: SBO:0000252
name: DPYSL3
has only substance units: false
constant: false
boundary condition: true
is: Q8IXW6
is encoded by: hsa:1809
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_61ab6707_9448_40ed_8168_4682fcdd43e0
is encoded by: hsa:11001
is: O14975
is: SBO:0000252
name: SLC27A2
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR PPD2CSPp
name: PPD2CSPp
reactant: MODEL1310110050#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_3dcfbaa4_676b_409c_a58b_97cbc640e501
constant: false
has only substance units: false
type: Species
is: P36269
name: GGT5
initial amount: NaN
boundary condition: true
is encoded by: hsa:2687
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_598562dd_1f8c_43fe_951f_7637473bc3a1
name: SLC25A22
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:79751
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9H936
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_19a4eef7_16d2_4f9f_bcb8_5e232face404
has only substance units: false
is encoded by: hsa:7359
type: Species
name: _7359_1_c
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

metaM bilglcur e
boundary condition: false
type: Species
is: CHEBI:57767
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
initial concentration: 1.0
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false

metaR r0488
fast: false
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#

metaR DM hretn n
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 4 hydroxy retinoic acid demand
type: Reaction

metaM HC01401 m
initial amount: NaN
has only substance units: false
is: CHEBI:27668
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

metaM 5aop m
has only substance units: false
is: HMDB01149
is: SBO:0000247
constant: false
is: CHEBI:17549
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: C00430
initial amount: NaN
name: 5-Amino-4-oxopentanoate

metaR ECOAH9m
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000304
product: MODEL1310110050#
is: SBO:0000176
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity

http://identifiers.org/biomodels.db/MODEL1310110050#_1950512b_6f43_4282_86c8_4292cf54dc21
type: Species
is encoded by: hsa:491
initial amount: NaN
has only substance units: false
is: Q4J699
initial concentration: NaN
name: ATP2B2
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_d6eda3eb_d1b4_4eb7_979f_206b93f540a5
type: Species
is encoded by: hsa:8897
boundary condition: true
name: MTMR3
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR AICART
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is: SBO:0000176
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000269
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.1.2.3
type: Reaction
reactant: MODEL1310110050#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_7e8f0684_fff4_4adb_bed2_d74c756c31b1
initial amount: NaN
is encoded by: hsa:6487
constant: false
initial concentration: NaN
name: ST3GAL3
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

metaR r1418
product: MODEL1310110050#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110050#
type: Reaction

metaR S6T7g
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110050#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
is described by: ECO:0000000

metaR r1011
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
name: Transport reaction
is: SBO:0000185
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_e395a131_0941_4805_a61c_7280a9de28d2
is encoded by: hsa:AI934540
name: _AI934540_1_c
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaM Rtotal e
is: HMDB00244
is: CHEBI:3554
type: Species
boundary condition: false
name: R total
has only substance units: false
is: C00255
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
initial amount: NaN

metaR UGALNACtg
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110050#
modifier: MODEL1310110050#
name: UDP-GalNAc Golgi transport via CMP antiport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110050#_1d8a99b2_9c4e_4b3c_add1_3ec7e9db0964
has only substance units: false
boundary condition: true
is encoded by: hsa:8372
name: HYAL3
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: O43820
is: SBO:0000252

metaM onpthl e
boundary condition: false
notes: FORMULA: C10H8O CHARGE: 0 INCHI: InChI=1/C10H8O/c1-2-4-8-7(3-1)5-6-9-10(8)11-9/h1-6,9-10H
initial amount: NaN
is: HMDB06215
type: Species
name: naphthalene epoxide
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaR r0638
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.2
type: Reaction
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110050#
is: SBO:0000176
reversible: true
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR r0311
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reactant: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
reversible: false
type: Reaction
kinetic law: MODEL1310110050#

metaR ADPCOACROT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaM gd2 hs g
has only substance units: false
constant: false
notes: FORMULA: C60H101N4O33FULLRCO CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: GD2
is: CHEBI:28648
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_f4ca4f4d_dbe2_447b_a00f_74a08aef593b
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:BC005314
is: SBO:0000252
boundary condition: true
type: Species
name: _BC005314_1_x
has only substance units: false
constant: false

metaM bilglcur c
boundary condition: false
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_c886f2f6_088b_4961_a6bd_1e195afcb637
initial amount: NaN
is: SBO:0000252
name: _AI761708_1_m
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AI761708
has only substance units: false
constant: false

metaR FORt2m
type: Reaction
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD,IT
name: formate mitochondrial transport
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000

metaM xol27oh m
has only substance units: false
is: CHEBI:17703
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
constant: false
name: 26-hydroxycholesterol
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r1010
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
name: Postulated transport reaction
type: Reaction

metaM sphings c
type: Species
name: sphingosine(1+)
is: SBO:0000247
is: HMDB00252
initial concentration: 1.0
is: CHEBI:57756
boundary condition: false
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
constant: false
initial amount: NaN

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_212afb76_0292_4a22_8ff9_392cbf9b1b15
type: Species
is encoded by: hsa:6547
initial concentration: NaN
constant: false
boundary condition: true
name: SLC8A3
initial amount: NaN
is: SBO:0000252
is: P57103
has only substance units: false

metaR METyLATthc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_c533869d_9ea4_468d_88ef_cfe9013e4fb1
is encoded by: hsa:8704
name: B4GALT2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: O60909
constant: false
type: Species
has only substance units: false

metaR INSTt2r
name: inositol transport in via proton symport
reversible: true
fast: false
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_04b2cdf8_2773_462d_8b2c_274a5c379b7d
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: GSTZ1
is: SBO:0000252
constant: false
is encoded by: hsa:2954

metaR ALAALACNc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: ALAALACNc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_4192256e_5a80_4e32_81d7_76ac2b7fe32a
type: Species
has only substance units: false
name: AK4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:205
boundary condition: true

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR ALAGLNexR
fast: false
product: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000185
type: Reaction
name: L-alanine/glutamine reversible exchange
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110050#

metaM urate c
name: Urate
is: C00366
constant: false
is: HMDB00289
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial amount: NaN
is: CHEBI:17775
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR PRO Dtde
product: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000134
fast: false
name: D-proline transport, extracellular
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reversible: true
kinetic law: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_34b997c1_cc3d_492d_bde5_e41ceb3330df
boundary condition: true
initial concentration: NaN
name: B3GALT5
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:10317

metaR DOLPH Ler
product: MODEL1310110050#
is: SBO:0000176
name: Dolichol-phosphate phosphohydrolase, human (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_fe712cbf_2e1e_42bc_8884_5a0b5ee62a94
is: SBO:0000252
is encoded by: hsa:2673
constant: false
boundary condition: true
initial amount: NaN
is: Q06210
has only substance units: false
type: Species
name: GFPT1
initial concentration: NaN

metaR r1597
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR GCC2cm
kinetic law: MODEL1310110050#
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.4.2

metaR r1866
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110050#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction

metaM 2mp2coa m
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: HMDB01011
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: CHEBI:27754
name: 2-Methylprop-2-enoyl-CoA
initial concentration: 1.0

metaR r2043
type: Reaction
fast: false
product: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110050#
modifier: MODEL1310110050#

metaM pi x
is: SBO:0000247
type: Species
is: HMDB00973
boundary condition: false
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
has only substance units: false
is: CHEBI:43474
initial concentration: 1.0
name: hydrogenphosphate

metaR r1598
reactant: MODEL1310110050#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#

metaR CRNCARtp
kinetic law: MODEL1310110050#
name: carnitine-acetylcarnitine carrier, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is: SBO:0000185
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110050#

metaR CHSTEROLtrc
reactant: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
type: Reaction
kinetic law: MODEL1310110050#
name: transport of cholesterol into the cytosol
fast: false
product: MODEL1310110050#
reversible: true
is described by: ECO:0000134

metaR PMANM
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
name: phosphomannomutase
is version of: http://identifiers.org/ec-code/5.4.2.8
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_62c61713_393c_4b46_86a1_89a2b2f1227c
name: COX7B2
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:170712
initial concentration: NaN
is: Q8TF08
type: Species

metaR LEUKTRA4t
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000269
reversible: true
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
name: leukotriene A4 transport

metaR RTOTALFATPc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR ETF
is: SBO:0000176
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
modifier: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: electron transfer flavoprotein
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_d52bef6f_a774_446b_95de_234827225c0b
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC4A4
constant: false
is encoded by: hsa:8671
is: A5JJ20

metaM urate e
initial concentration: 1.0
name: Urate
is: HMDB00289
initial amount: NaN
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00366
constant: false

metaM pail4p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_47966340_8029_44bb_b584_5aa6b88615cb
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:60490
name: PPCDC
type: Species
is: SBO:0000252
has only substance units: false
is: Q96CD2

metaM glc D r
name: D-glucose
is: CHEBI:4167
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00122
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
initial concentration: 1.0

metaR q10h2tc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110050#
type: Reaction
reversible: true
name: transport of ubiquinol into cytosol
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
fast: false
is described by: ECO:0000134

metaR FALDH
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.1
name: formaldehyde dehydrogenase
reversible: true
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#

metaR r1599
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110050#_fd7358f7_672d_4ce4_aa2d_95b32b2e999c
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: BLVRB
initial concentration: NaN
is encoded by: hsa:645
is: P30043
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f0fa2ca1_da0e_4209_be3f_c306caa93116
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC8A3
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:6547

metaM bildglcur e
constant: false
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN
boundary condition: false
is: HMDB03325
is: SBO:0000247
has only substance units: false
is: CHEBI:58471
type: Species

metaR r2041
product: MODEL1310110050#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
modifier: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_329f1fdd_497e_4e5c_b609_9df54c375cf7
is: SBO:0000252
initial concentration: NaN
is: B7Z6S9
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2629
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110050#_fbe9002a_b559_4e52_a6f4_3319c2596c09
is: Q86YN1
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: DOLPP1
initial concentration: NaN
type: Species
is encoded by: hsa:57171

http://identifiers.org/biomodels.db/MODEL1310110050#_c48e2ed0_32a7_491b_874c_f61c4e10518c
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: P14618
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5315
name: PKM2
constant: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_abd00f5c_6af9_41dd_9da5_a94abaa20745
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:53354
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: PANK1
is: Q8TE04

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM naglc2p L c
boundary condition: false
has only substance units: false
is: CHEBI:18278
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
initial concentration: 1.0
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
initial amount: NaN

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM ibcoa m
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
name: isobutyryl-CoA(4-)
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57338
initial concentration: 1.0
is: HMDB01243
is: SBO:0000247
type: Species

metaM dhcholestanate c
initial concentration: 1.0
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
is: SBO:0000247
is: HMDB00359
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
has only substance units: false

metaM 5aop c
type: Species
constant: false
is: CHEBI:17549
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 5-Amino-4-oxopentanoate
is: HMDB01149
is: SBO:0000247
is: C00430

metaM for e
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
constant: false
has only substance units: false
is: SBO:0000247
name: formate
boundary condition: false
initial concentration: 1.0
is: CHEBI:15740
type: Species
initial amount: NaN

metaM tdchola c
has only substance units: false
is: HMDB00951
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
type: Species
initial amount: NaN
name: taurochenodeoxycholate
is: SBO:0000247
boundary condition: false
constant: false

metaM ksi pre19 g
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 19
is: SBO:0000247
is: HMDB06552
has only substance units: false
is: CHEBI:2504
type: Species
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
initial concentration: 1.0
constant: false
initial amount: NaN

metaM bildglcur c
initial concentration: 1.0
has only substance units: false
is: HMDB03325
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
initial amount: NaN
is: CHEBI:58471
type: Species
constant: false

metaM c4dc x
boundary condition: false
name: succinyl carnitine
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H18NO6 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C02862
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
type: Species

metaM hmgcoa c
boundary condition: false
constant: false
type: Species
is: CHEBI:15467
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR G12MT2 L
reversible: false
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_642fbb09_f196_4387_93ef_943d35c2b651
name: GALNT5
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11227
is: A5PKZ1
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaM prpncoa m
name: acryloyl-CoA(4-)
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02307
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57367
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_5a0d61e0_6057_460d_b6e0_65fc17afbfad
type: Species
is: SBO:0000252
boundary condition: true
name: SLC27A1
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:376497
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_71819fdd_31ae_4392_89c2_42741974adef
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PIK3C3
is: SBO:0000252
type: Species
is: Q8NEB9
is encoded by: hsa:5289
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_05e97dce_8ebb_42af_afb2_2992ccc056d7
initial concentration: NaN
is: SBO:0000252
name: CHST1
type: Species
has only substance units: false
constant: false
is encoded by: hsa:8534
boundary condition: true
is: O43916
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_28b06ccb_dbc1_48aa_a904_a0b34aa35906
initial amount: NaN
type: Species
is: O14561
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4706
name: NDUFAB1

metaM vacc e
is: CHEBI:30828
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: trans-vaccenate
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
has only substance units: false

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_20e3deff_cfe1_43e7_a8ff_ab07d0f09af5
is: P10619
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5476
name: CTSA
boundary condition: true
constant: false

metaM duri n
is: HMDB00012
initial amount: NaN
is: CHEBI:16450
name: 2'-deoxyuridine
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false

metaM ksi pre1 g
constant: false
is: HMDB06552
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: CHEBI:2504
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 1
has only substance units: false
type: Species
initial amount: NaN

metaR BILDGLCURt
is: SBO:0000185
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
type: Reaction
reactant: MODEL1310110050#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
fast: false
is described by: ECO:0000269
product: MODEL1310110050#

metaR FUM
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110050#
reactant: MODEL1310110050#
name: fumarase
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000176
modifier: MODEL1310110050#

metaM mi145p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: CHEBI:203600
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01498

metaR DMHPTCRNCPT2
name: 2,6 dimethylheptanoly CoA carnitine transferase
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_0e3d1cdb_b96e_4c19_96a5_fb1e010a096d
initial concentration: NaN
type: Species
boundary condition: true
name: ACSL6
constant: false
is: SBO:0000252
is: B2RB13
has only substance units: false
is encoded by: hsa:23305
initial amount: NaN

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM g2m8masn r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
initial concentration: 1.0
is: C05874
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C82H137N2O65X CHARGE: 0

metaR ACGALK
reversible: false
name: N-acetylgalactosamine kinase
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000000

metaR B3GALT42g
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.62
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
is: SBO:0000176
modifier: MODEL1310110050#
name: Beta-1,3-galactosyltransferase 4
kinetic law: MODEL1310110050#

metaM for c
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
is: HMDB00142
has only substance units: false
constant: false
name: Formate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15740
is: C00058

metaR PHEMEtm
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
type: Reaction
name: Heme transport to cytosol
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reversible: true
product: MODEL1310110050#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_f95fff44_a5f9_4ae9_838e_2c8b5a01364b
is encoded by: hsa:80270
initial amount: NaN
initial concentration: NaN
is: Q9H2F3
has only substance units: false
name: HSD3B7
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaR ASCBt
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
name: L-ascorbate transport via facilitated diffusion
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000185

metaR GGH 5DHFe
name: Gamma-glutamyl hydrolase (5DHF), extracellular
modifier: MODEL1310110050#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000

metaR S6T9g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110050#

metaR RE3627M
reactant: MODEL1310110050#
type: Reaction
name: RE3627
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_ef9958b4_eb0b_45d6_b731_02a700e4c75f
is: SBO:0000252
is encoded by: hsa:6648
has only substance units: false
initial amount: NaN
constant: false
name: SOD2
is: P04179
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_dbaf3476_883c_47d4_8db3_51ec3af55313
initial amount: NaN
initial concentration: NaN
name: SUCLG1:SUCLA2
constant: false
has only substance units: false
is encoded by: hsa:8803
type: Species
has part: E5KS60
boundary condition: true
is: SBO:0000297

metaM galgluside hs g
initial amount: NaN
is: SBO:0000247
is: HMDB00295
constant: false
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
is: C00015
type: Species
boundary condition: false
is: CHEBI:58223
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_619ba8ca_c0f2_4a9b_812e_c97f12d09866
is: P37268
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2222
name: FDFT1
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_03727851_82d2_4f85_8c2b_4cc687b71ba9
is: SBO:0000252
is encoded by: hsa:29968
boundary condition: true
type: Species
has only substance units: false
constant: false
name: PSAT1
initial concentration: NaN
initial amount: NaN
is: Q9Y617

metaM m5mpdol L r
constant: false
is: CHEBI:37634
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
is: SBO:0000247
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR NACHEX2ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_cc07f777_2958_4d69_b7a4_92a45d15e058
name: SLC19A3
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9BZV2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80704

metaR DASCBR
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.8.4.1
is described by: ECO:0000269
product: MODEL1310110050#
type: Reaction
name: dehydroascorbate reductase
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
reversible: false

metaR MMMm
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
reversible: true
name: methylmalonyl-CoA mutase
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/5.4.99.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_f2c7f938_7002_4a96_80d7_24edf50e4836
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:U37519
initial concentration: NaN
boundary condition: true
name: _U37519_1_c

metaR LPCOXp
fast: false
is described by: ECO:0000269
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is version of: http://identifiers.org/ec-code/1.5.3.1
name: L-pipecolate oxidase, peroxisomal
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_58b91788_1a05_4bbf_bf99_64c36114df22
is: SBO:0000252
initial concentration: NaN
is: P30837
boundary condition: true
is encoded by: hsa:219
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ALDH1B1

metaR PI4PLCn
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110050#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110050#
fast: false
is: SBO:0000176
modifier: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_5e923cc3_fee9_42dc_adc4_53993c5e5e09
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:7296
initial concentration: NaN
is: SBO:0000252
name: TXNRD1
has only substance units: false

metaR NMNATn
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110050#
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
name: nicotinamide-nucleotide adenylyltransferase
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
is version of: http://identifiers.org/ec-code/2.7.7.1
reversible: false

metaM 2dr1p c
name: 2-Deoxy-D-ribose 1-phosphate
is: HMDB01351
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
constant: false
is: C00672
initial concentration: 1.0
is: CHEBI:58576
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_0e438514_efcb_4342_bc91_7df80ddb0d61
initial concentration: NaN
has only substance units: false
is: Q6LEN5
initial amount: NaN
is: SBO:0000252
name: CHAT
boundary condition: true
type: Species
constant: false
is encoded by: hsa:1103

metaM maltttr e
constant: false
is: C02052
has only substance units: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
name: Maltotetraose
type: Species
initial concentration: 1.0
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: HMDB01296

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR NCKt
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000269
name: Na+/Ca2+-K+ exchange
fast: false

metaR DURIt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110050#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110050#
reversible: true
name: deoxyuridine transport via diffusion
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaM cs b deg1 l
has only substance units: false
initial concentration: 1.0
is: HMDB00812
constant: false
initial amount: NaN
is: CHEBI:16953
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
boundary condition: false
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1

http://identifiers.org/biomodels.db/MODEL1310110050#_32b20b04_297e_4ede_ac57_071b2f2de5d8
is encoded by: hsa:6521
initial concentration: NaN
is: P02730
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: SLC4A1
constant: false
boundary condition: true

metaM ksi pre21 g
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06552
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:2504
name: keratan sulfate I biosynthesis, precursor 21
notes: FORMULA: C177H284N12O145S6X CHARGE: -7

metaM ivcrn e
notes: FORMULA: C12H23NO4 CHARGE: 0
initial amount: NaN
boundary condition: false
is: HMDB00688
is: SBO:0000247
name: isovaleryl carnitine
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR 3SALAASPm
is: SBO:0000185
is described by: ECO:0000304
reversible: true
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
name: cysteinesulfinate-aspartate mitochondrial shuttle
kinetic law: MODEL1310110050#
fast: false
type: Reaction
product: MODEL1310110050#
modifier: MODEL1310110050#

metaM cspg e e
boundary condition: false
initial amount: NaN
is: HMDB00300
is: C00106
type: Species
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:17568

metaR ACGALtly
reversible: false
reactant: MODEL1310110050#
product: MODEL1310110050#
name: N-acetyl-galactosamine lysosomal efflux
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5a53e5ea_8d86_4e9c_8662_f6a4a8c2bb43
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4719
is: P28331
constant: false
is: SBO:0000252
name: NDUFS1
boundary condition: true
initial amount: NaN
type: Species

metaR RE1517M
fast: false
reactant: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110050#
name: RE1517
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR RBTt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
fast: false
name: ribitol transport via passive diffusion

http://identifiers.org/biomodels.db/MODEL1310110050#_108de3b9_87b5_4a14_9b1d_b89ee16457f4
has only substance units: false
initial concentration: NaN
name: DPM1
constant: false
is: O60762
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:8813
is: SBO:0000252

metaR r0774
is described by: ECO:0000000
product: MODEL1310110050#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110050#

metaR ITCOALm
type: Reaction
is: SBO:0000176
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaR RE2651R
type: Reaction
kinetic law: MODEL1310110050#
name: RE2651
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
fast: false
is: SBO:0000176

metaR r1450
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
type: Reaction
name: EC:1.3.3.6
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110050#
reversible: false

metaR UAGALDP
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: UDP-N-acetylgalactosamine diphosphorylase
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_8c935ba1_838f_4b7d_9585_f6c46a7c69e9
type: Species
is encoded by: hsa:22978
has only substance units: false
is: SBO:0000252
is: P49902
name: NT5C2
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

metaR PPAt
kinetic law: MODEL1310110050#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110050#
name: Propionate transport, diffusion
reversible: false
reactant: MODEL1310110050#

metaR CSCPASEly
product: MODEL1310110050#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
reactant: MODEL1310110050#
reversible: false
name: chondroitin sulfate C proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_fad995d3_86af_4396_be5d_c96bc131325f
is: P06132
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: UROD
boundary condition: true
has only substance units: false
is encoded by: hsa:7389
is: SBO:0000252

metaM 34dhpha c
constant: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
initial amount: NaN
has only substance units: false
name: (3,4-dihydroxyphenyl)acetate
initial concentration: 1.0
is: HMDB01336
type: Species
is: CHEBI:17612
boundary condition: false
is: SBO:0000247

metaM leuktrC4 c
constant: false
initial concentration: 1.0
boundary condition: false
name: leukotriene C4(2-)
has only substance units: false
is: CHEBI:57973
is: HMDB01198
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaM dhcholestanate r
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
initial amount: NaN
is: HMDB00359

metaM pi r
initial concentration: 1.0
boundary condition: false
name: hydrogenphosphate
is: CHEBI:43474
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C00009
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR FATP9t
is version of: http://identifiers.org/ec-code/6.2.1.7
reversible: true
name: fatty acid electroneutral transport
reactant: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110050#
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_71e8b008_4b92_4493_961b_6fe3353604c2
is encoded by: hsa:374907
name: B3GNT8
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q7Z7M8
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_f75de216_d516_4bea_b767_8c588b7ef599
type: Species
initial amount: NaN
boundary condition: true
is: Q8WWX8
constant: false
has only substance units: false
is encoded by: hsa:115584
is: SBO:0000252
initial concentration: NaN
name: SLC5A11

http://identifiers.org/biomodels.db/MODEL1310110050#_7699b573_c31a_4165_94ab_9447e6ae98da
initial concentration: NaN
name: SLC2A3
constant: false
is encoded by: hsa:6515
has only substance units: false
type: Species
is: P11169
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR FAOXC140
reversible: false
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR ADPACTD
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaR TCHOLAte
is: SBO:0000185
kinetic law: MODEL1310110050#
fast: false
reversible: true
type: Reaction
name: bile acid intracellular transport
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaM ivcrn c
notes: FORMULA: C12H23NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB00688
has only substance units: false
name: isovaleryl carnitine
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

metaR r1451
type: Reaction
name: EC:1.3.3.6
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaM Rtotal2coa c
constant: false
type: Species
name: R total 2 coenzyme A
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: C00055
initial concentration: 1.0
is: HMDB00095
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:60377
initial amount: NaN

metaR RIBt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110050#
reversible: true
name: ribose transport via diffusion
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_e9f5545d_4582_46a9_ae13_0c7cfcc73089
is encoded by: hsa:80201
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: HKDC1
is: B3KT70
type: Species
has only substance units: false

metaR NMNATr
is version of: http://identifiers.org/ec-code/2.7.7.1
product: MODEL1310110050#
name: nicotinamide-nucleotide adenylyltransferase
is: SBO:0000176
modifier: MODEL1310110050#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
type: Reaction

metaR RE3421R
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
reversible: true
name: RE3421
type: Reaction
is described by: ECO:0000000

W3 CDTF: Thu Aug 30 09:57:43 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110050#_06e5b03e_d3b4_465a_a1b2_39e8a040a2b4
type: Species
is: SBO:0000252
boundary condition: true
is: Q5I0G3
has only substance units: false
is encoded by: hsa:130752
initial amount: NaN
constant: false
name: MDH1B
initial concentration: NaN

metaM urcan c
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00301
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
name: Urocanate
type: Species
is: CHEBI:17771
is: C00785
constant: false
initial concentration: 1.0

metaR RE1447N
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
name: RE1447
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110050#

metaM trp L c
is: SBO:0000247
is: CHEBI:16828
is: HMDB00929
name: L-tryptophan
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_948c4caa_776a_4d59_9c36_4e147f15a47e
name: MYO5B
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4645
constant: false
has only substance units: false
is: Q9H6Y6

metaR RE2426C
is: SBO:0000176
name: RE2426
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
reactant: MODEL1310110050#

metaM ppa m
is: HMDB00237
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: propionate
initial concentration: 1.0
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN

metaM HC02203 e
initial amount: NaN
name: prostaglandin-a2
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:27820
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
is: SBO:0000247

metaM for m
has only substance units: false
name: formate
is: HMDB00142
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
is: CHEBI:15740
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_a579df5d_24c0_45ff_9dac_006cc87ae110
is: Q7KZA3
name: FECH
has only substance units: false
is encoded by: hsa:2235
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR PPAm
type: Reaction
kinetic law: MODEL1310110050#
fast: false
reversible: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000269
is: SBO:0000176
name: inorganic diphosphatase
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF

metaM CE2434 m
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
constant: false
type: Species
is: SBO:0000247
is: CHEBI:57795
initial amount: NaN
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA

metaM gt2 hs g
constant: false
initial concentration: 1.0
notes: FORMULA: C71H117N5O41FULLRCO CHARGE: -3
name: GT2
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:28648

W3 CDTF: Thu Aug 30 09:57:43 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110050#_185ad247_7946_4434_b4e0_c797375aec11
is encoded by: hsa:5634
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: P11908
boundary condition: true
name: PRPS2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_da3f507c_37c4_4634_bba7_65b21584f57a
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2819
type: Species
name: GPD1
is: F8W1L5
initial concentration: NaN

metaM hcoumarin e
type: Species
constant: false
is: CHEBI:27510
is: SBO:0000247
initial concentration: 1.0
name: umbelliferone
initial amount: NaN
is: C09315
notes: FORMULA: C9H6O3 CHARGE: 0 INCHI: InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
has only substance units: false
boundary condition: false

metaM 5fthf m
is: CHEBI:57457
is: HMDB01562
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: 5-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM hmgcoa m
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
constant: false
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_567475c6_52ae_43ac_b32e_ca5f4cfebdf5
initial amount: NaN
is encoded by: hsa:55350
is: SBO:0000252
boundary condition: true
name: VNN3
has only substance units: false
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_523ddde6_1ff7_472b_97fa_e388ebb2d405
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: VNN2
is: A8K7W0
type: Species
is encoded by: hsa:8875

metaM dhcholestanate m
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00359
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR PE HSter
kinetic law: MODEL1310110050#
name: phosphatidylethanolamine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reactant: MODEL1310110050#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110050#
is described by: ECO:0000000
fast: false

metaM 20ahchsterol m
constant: false
is: CHEBI:1296
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: HMDB06283
name: 20-hydroxycholesterol
has only substance units: false

metaM c6dc c
is: SBO:0000247
notes: FORMULA: C13H22NO6 CHARGE: -1
initial amount: NaN
boundary condition: false
name: adipoyl carnitine
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: HMDB13130

metaM HC02203 c
is: CHEBI:27820
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
name: prostaglandin-a2
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_b5a2c8a2_3a32_459a_af64_a734f3de804f
is encoded by: hsa:2582
initial amount: NaN
is: Q14376
name: GALE
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaR r1177
fast: false
is described by: ECO:0000000
name: EC:3.1.1.13
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
product: MODEL1310110050#
is: SBO:0000176

metaR DGNSKm
is version of: http://identifiers.org/ec-code/2.7.1.113
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
reversible: false
type: Reaction
modifier: MODEL1310110050#
fast: false
name: deoxyguanosine kinase
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000269

metaR GCCcm
product: MODEL1310110050#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110050#
is: SBO:0000176
name: glycine-cleavage complex (lipoylprotein), mitochondrial

metaR RE1447M
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.41
name: RE1447
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
product: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
is: SBO:0000176

metaM trp L e
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00929
is: SBO:0000247
name: L-tryptophan
is: CHEBI:16828
has only substance units: false

metaR FAOXC16180m
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
reversible: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
name: Beta oxidation fatty acid

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM no c
is: HMDB03378
is: C00533
has only substance units: false
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: Nitric oxide
boundary condition: false

metaM hcoumarin c
type: Species
constant: false
is: CHEBI:27510
name: umbelliferone
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H6O3 CHARGE: 0 INCHI: InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
is: C09315
boundary condition: false

metaM duri e
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
constant: false
type: Species
is: SBO:0000247
is: HMDB00012
has only substance units: false
initial amount: NaN
name: Deoxyuridine
boundary condition: false
initial concentration: 1.0
is: C00526

metaM no e
constant: false
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
name: Nitric oxide
is: CHEBI:16480
has only substance units: false
is: HMDB03378
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM s2l2n2m2masn e
type: Species
is: CHEBI:3554
notes: FORMULA: C84H135N6O61X CHARGE: -2
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00255
has only substance units: false
is: HMDB00244
initial amount: NaN
name: de-Fuc form of PA6
constant: false

metaM 5HPET c
initial amount: NaN
has only substance units: false
is: CHEBI:57450
type: Species
initial concentration: 1.0
is: HMDB01193
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
boundary condition: false
constant: false
name: 5(S)-HPETE(1-)

metaR D3AIBTm
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
fast: false

metaM glc D e
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:4167
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose

metaR NADPHtru
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
reversible: false
name: NADPH transporter, endoplasmic reticulum

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR r1445
type: Reaction
name: EC:1.3.3.6
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000

metaR r2376
product: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
reversible: true

metaR r0779
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
type: Reaction
modifier: MODEL1310110050#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is described by: ECO:0000000

metaR RE3270C
product: MODEL1310110050#
is: SBO:0000176
name: RE3270
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton

metaR GLCNACT L
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
reversible: false
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)

metaR TYRCBOX
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
is version of: http://identifiers.org/ec-code/4.1.1.28
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000134
fast: false
name: L-Tyrosine carboxy-lyase
reversible: false

metaM dhcholestanate x
is: HMDB00359
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16577
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaM spc hs c
type: Species
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5311445
boundary condition: false
name: sphingosylphosphorylcholine
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1

metaR CYTK2n
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP),nuclear
reversible: true
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110050#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110050#_4e7cd4c2_0626_46ba_aaa9_3da1bf3d9856
type: Species
is: P00414
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4514
name: COX3
constant: false

metaM thbpt4acam c
initial concentration: 1.0
is: HMDB02281
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
is: SBO:0000247
has only substance units: false
name: 4a-hydroxytetrahydrobiopterin
constant: false

metaR r2375
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110050#

metaR HIStN1
reversible: true
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110050#
name: Histidine transport (Na, H coupled)
modifier: MODEL1310110050#
type: Reaction
product: MODEL1310110050#

metaR r1444
product: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
name: EC:1.3.3.6
is described by: ECO:0000000
type: Reaction

metaM dolichol L r
notes: FORMULA: C1080H1768O10 CHARGE: 0
initial amount: NaN
is: CHEBI:16091
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Dolichol, human liver homolog
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_4d9a6c4c_eacb_40b9_9139_66e99dbaf679
constant: false
is: P09923
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ALPI
initial amount: NaN
is encoded by: hsa:248

metaM glc D c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: CHEBI:4167
boundary condition: false

metaR PItx
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Phosphate transporter, peroxisome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
type: Reaction

metaM hLkynr c
initial amount: NaN
is: CHEBI:17380
has only substance units: false
name: 3-hydroxy-L-kynurenine
constant: false
type: Species
boundary condition: false
is: HMDB11631
initial concentration: 1.0
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: SBO:0000247

metaM leuktrD4 c
is: CHEBI:28666
boundary condition: false
name: Leukotriene D4
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

metaR r2378
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#

metaM duri c
is: HMDB00012
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
initial concentration: 1.0
is: C00526
is: CHEBI:16450
initial amount: NaN
name: Deoxyuridine
type: Species

metaR URIK1
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
reversible: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
kinetic law: MODEL1310110050#
name: uridine kinase (ATP:Uridine)
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269
fast: false

metaR r0932
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#

metaM npthl e
is: C00829
type: Species
notes: FORMULA: C10H8 CHARGE: 0 INCHI: InChI=1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H EHMN_ABBREVIATION: C00829
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
name: naphthalene
is: CHEBI:16482
has only substance units: false

metaM acgal1p c
type: Species
initial amount: NaN
is: HMDB06480
is: SBO:0000247
has only substance units: false
is: CHEBI:55404
boundary condition: false
name: N-Acetyl-D-galactosamine 1-phosphate
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
constant: false

metaR ALAGLYexR
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110050#
type: Reaction
name: L-alanine/glycine reversible exchange

metaM srtn e
boundary condition: false
name: serotonin(1+)
constant: false
is: CHEBI:350546
is: HMDB00259
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial amount: NaN
type: Species
has only substance units: false

metaM acetone m
is: HMDB01659
name: acetone
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR INSTt4 2
reactant: MODEL1310110050#
name: inositol transport via sodium symport
product: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
is described by: ECO:0000006
fast: false
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_e544cd75_eb4d_49ef_a4a6_9196601aeb65
name: XDH
type: Species
initial amount: NaN
has only substance units: false
is: P47989
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:7498
boundary condition: true

metaR C81CRNe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM cspg e l
type: Species
has only substance units: false
is: HMDB02183
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: CHEBI:36005
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan

metaR FAS120COA
is: SBO:0000176
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
modifier: MODEL1310110050#
reversible: false
type: Reaction
product: MODEL1310110050#
name: fatty-acyl-CoA synthase (n-C12:0CoA)

metaR r0340
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.1.38
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110050#

metaM 2hb c
is: SBO:0000247
initial amount: NaN
is: CHEBI:1148
is: HMDB00008
has only substance units: false
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
initial concentration: 1.0
boundary condition: false
name: 2-Hydroxybutyrate

metaR r0931
reversible: false
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
name: Transport reaction

metaR r2377
product: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
fast: false

metaR r1446
is: SBO:0000176
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
name: EC:1.3.3.6

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaM leuktrD4 e
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB03080
is: CHEBI:28666
name: Leukotriene D4
has only substance units: false

metaM 5fthf e
type: Species
name: 5-formyltetrahydrofolate(2-)
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57457
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: HMDB01562

http://identifiers.org/biomodels.db/MODEL1310110050#_98a53f36_ca14_4d40_9b56_fdc174cab656
initial concentration: NaN
has only substance units: false
has part: P23378
boundary condition: true
name: DLD:GCSH:GLDC:AMT
is: SBO:0000297
is encoded by: hsa:2731
is encoded by: hsa:2653
type: Species
has part: P48728
constant: false
is encoded by: hsa:275
initial amount: NaN
has part: P23434

http://identifiers.org/biomodels.db/MODEL1310110050#_cf420d62_8b03_4ce2_8c06_345207944968
constant: false
boundary condition: true
is: Q9GZV3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:60482
name: SLC5A7
initial amount: NaN
has only substance units: false
type: Species

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_2b38b5a1_cdda_45ef_8023_49ebb6cab9f4
boundary condition: true
initial amount: NaN
name: PLA2G2E
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:30814
constant: false
initial concentration: NaN
is: Q9NZK7

http://identifiers.org/biomodels.db/MODEL1310110050#_1170e86d_6c12_40f3_9052_b3b78f52055f
initial amount: NaN
type: Species
is encoded by: hsa:284111
initial concentration: NaN
constant: false
name: SLC13A5
has only substance units: false
boundary condition: true
is: Q86YT5
is: SBO:0000252

metaM hs deg19 l
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
type: Species
initial amount: NaN
has only substance units: false
is: HMDB06254
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: heparan sulfate, degradation product 19

metaM npthl c
initial concentration: 1.0
notes: FORMULA: C10H8 CHARGE: 0 INCHI: InChI=1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H EHMN_ABBREVIATION: C00829
boundary condition: false
is: SBO:0000247
name: naphthalene
is: C00829
type: Species
initial amount: NaN
is: CHEBI:16482
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_e96ef6d3_8925_4378_8b13_f6cf15a2f2b9
is: O00754
constant: false
initial concentration: NaN
name: MAN2B1
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4125

metaM lpro m
boundary condition: false
is: CHEBI:15804
name: Lipoylprotein
is: SBO:0000247
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR HMGCOAtx
reversible: true
product: MODEL1310110050#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR PI345P5P
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110050#
type: Reaction

metaR r0345
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:

metaM hs deg21 l
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16126
notes: FORMULA: C37H55NO38S2 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110050#_4855e0d4_7573_4db7_bba4_5310983e1c3e
is encoded by: hsa:10195
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
name: ALG3
is: Q92685

http://identifiers.org/biomodels.db/MODEL1310110050#_a4d15329_f436_4252_90fb_21145734dc06
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O15244
is encoded by: hsa:6582
type: Species
initial concentration: NaN
name: SLC22A2
boundary condition: true
constant: false

metaR ST8SIA54g
reactant: MODEL1310110050#
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
type: Reaction
is described by: ECO:0000269
reversible: false
is: SBO:0000176
fast: false

metaR ADPACDAc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaM srtn c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:350546
name: serotonin(1+)
type: Species
constant: false
is: HMDB00259
is: SBO:0000247
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
boundary condition: false
has only substance units: false

metaR r0829
modifier: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.37
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

http://identifiers.org/biomodels.db/MODEL1310110050#_d591982e_3edc_415c_bada_480ea3e70783
is: P49902
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: NT5C2
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:22978

metaM psylchol e
is: SBO:0000247
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/79101
initial amount: NaN
is: HMDB00721
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
type: Species
name: psillium-glycocholic acid complex
initial concentration: 1.0
has only substance units: false

metaM c8crn e
type: Species
initial amount: NaN
is: SBO:0000247
name: octanoyl carnitine
is: HMDB00791
initial concentration: 1.0
is: C02838
notes: FORMULA: C15H29NO4 CHARGE: 0
constant: false
boundary condition: false
has only substance units: false

metaR r2379
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM cs e l
is: SBO:0000247
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
constant: false
is: HMDB02183
initial amount: NaN
is: CHEBI:36005

http://identifiers.org/biomodels.db/MODEL1310110050#_aa8862c3_3d5c_4b3f_b281_a582fa1f95c1
boundary condition: true
is: SBO:0000252
is: O43865
initial concentration: NaN
constant: false
is encoded by: hsa:10768
name: AHCYL1
has only substance units: false
type: Species
initial amount: NaN

metaM 2hb e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:1148
is: HMDB00008
name: 2-Hydroxybutyrate
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984

metaR ACHtn
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reversible: true
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
name: Acetylcholin transport, nuclear trhough pores

metaM malthx e
is: C01936
name: Maltohexaose
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_256cc0d6_2ee7_43a8_866b_3cdee37d1fc8
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: E9PCI1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:53
name: ACP2
constant: false

metaR MELATNOX
is described by: ECO:0000269
is: SBO:0000176
name: Melatonin:NADP oxidoreductase
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
fast: false
reversible: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.14.13.48
is version of: http://identifiers.org/ec-code/1.14.14.1

http://identifiers.org/biomodels.db/MODEL1310110050#_ed9c9435_495c_44ce_9449_a3cf511fb3a1
type: Species
is encoded by: hsa:4830
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: NME1

metaR r0321
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is: SBO:0000176
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.3.5.2
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:

metaR r1443
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
name: EC:1.3.3.6
fast: false
type: Reaction

metaR RE1573M
name: RE1573
modifier: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reactant: MODEL1310110050#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110050#

metaM elaidcrn m
type: Species
name: Elaidic carnitine
is: HMDB06464
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_e691a175_4b9e_40e6_b45c_e76c2aee47d4
constant: false
is encoded by: hsa:160851
name: DGKH
boundary condition: true
has only substance units: false
is: A8K0I1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR HDCEAtr
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185

metaM spc hs e
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5311445
initial concentration: 1.0
name: sphingosylphosphorylcholine
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
constant: false

metaR DM fol
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_4c7492a9_8b78_4c76_9672_58022d47dc1b
initial concentration: NaN
is: P15121
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: AKR1B1
is encoded by: hsa:231

metaR DALAt2r
reversible: true
fast: false
product: MODEL1310110050#
modifier: MODEL1310110050#
name: D-alanine transport via proton symport
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
is described by: ECO:0000304
kinetic law: MODEL1310110050#

metaM c8crn c
type: Species
name: octanoyl carnitine
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H29NO4 CHARGE: 0
is: HMDB00791
boundary condition: false
is: C02838
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_b198d705_0372_43b1_b82d_f952167c21bb
is encoded by: hsa:54677
is: SBO:0000252
is: E7EQF2
type: Species
has only substance units: false
name: CROT
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaM 2oxoadp c
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
initial amount: NaN
is: HMDB00225
is: SBO:0000247
is: CHEBI:57499
has only substance units: false
initial concentration: 1.0
name: 2-oxoadipate(2-)
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_1d6db395_bd9c_441a_a57a_e6f446810350
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: AMY1B
has only substance units: false
is: P04745
is encoded by: hsa:277

metaR RE2649M
modifier: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: RE2649
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110050#
type: Reaction

metaM cs d deg3 l
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C37H54NO41S3 CHARGE: -5
initial amount: NaN
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 3
type: Species
is: CHEBI:15748
initial concentration: 1.0
is: HMDB00127

metaR ACALDt
name: acetaldehyde reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR r0074
reactant: MODEL1310110050#
reversible: true
product: MODEL1310110050#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_a9401f28_f7e5_4785_a4ce_5d1940c70de3
name: PDE4D
type: Species
is: SBO:0000252
boundary condition: true
is: Q08499
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:5144
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_eb985f5b_fb29_4d6c_97e7_d1032d44c580
is: SBO:0000297
has part: O95497
is encoded by: hsa:8876
has only substance units: false
is encoded by: hsa:8875
is encoded by: hsa:55350
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: VNN3:VNN2:VNN1
constant: false
has part: A8K7W0

metaR RETH1e
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
name: retinyl ester hydrolase (9-cis), extracellular
is: SBO:0000176

metaM mi134p c
type: Species
constant: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: HMDB01143
has only substance units: false
initial concentration: 1.0
is: CHEBI:58414
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
boundary condition: false

metaR FAOXC16BRx
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaM pail4p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178

metaM HC01415 m
has only substance units: false
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
type: Species
is: SBO:0000247
name: (2E)-Octenoyl-CoA
boundary condition: false
initial concentration: 1.0
is: CHEBI:27537
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_e0cf5073_3f71_44c3_92b8_d30671921310
initial concentration: NaN
type: Species
boundary condition: true
is: Q96P26
constant: false
is encoded by: hsa:93034
is: SBO:0000252
has only substance units: false
name: NT5C1B
initial amount: NaN

metaR r0627
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
reversible: true
product: MODEL1310110050#
is: SBO:0000176

metaR r0937
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: true

metaM gp1calpha hs c
initial amount: NaN
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
is: HMDB00618
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: GP1c alpha
constant: false
is: CHEBI:58121
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_ef2d5323_a5fe_486d_9c9c_80a123f32137
is encoded by: hsa:6675
constant: false
has only substance units: false
initial concentration: NaN
is: Q16222
name: UAP1
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaM clpn hs c
constant: false
has only substance units: false
notes: FORMULA: CHARGE: 0
is: SBO:0000247
is: CHEBI:21338
boundary condition: false
name: clpn_hs[c]
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB02704

http://identifiers.org/biomodels.db/MODEL1310110050#_ecf53c12_d5b6_4a1a_ad6f_52b9d34c7f4e
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:7108
initial amount: NaN
name: TM7SF2
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O76062

metaM aps c
is: CHEBI:58243
constant: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
boundary condition: false
name: 5'-adenylyl sulfate(2-)
is: HMDB01003
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_ec3b057b_d237_4edb_9032_ea87cd038c76
is: O43181
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFS4
constant: false
is encoded by: hsa:4724
initial concentration: NaN

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM gm1 hs g
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C55H95N3O30FULLRCO CHARGE: -1
boundary condition: false
is: CHEBI:18216
name: ganglioside GM1
constant: false

metaM pacald c
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
has only substance units: false
initial amount: NaN
is: CHEBI:16424
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06236
name: phenylacetaldehyde
is: SBO:0000247
constant: false

metaR BILDGLCURtr
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
name: glucuronidated compound transport
fast: false

metaR LPS3e
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
is: SBO:0000176
fast: false
name: lipase, extracellular
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_4d4aec60_5292_41fe_a656_8bc71dc8e116
initial concentration: NaN
is: A8K0T6
boundary condition: true
initial amount: NaN
constant: false
name: SMPD3
is: SBO:0000252
is encoded by: hsa:55512
type: Species
has only substance units: false

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaR FAOXC11
name: Beta oxidation of long chain fatty acid
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000

metaR RNMK
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000269
kinetic law: MODEL1310110050#
reversible: false
name: ribosylnicotinamide kinase
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
modifier: MODEL1310110050#
product: MODEL1310110050#

metaR GGH 7THFe
type: Reaction
reversible: false
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
name: Gamma-glutamyl hydrolase (7THF), extracellular

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM 3snpyr m
is: SBO:0000247
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: HMDB02332
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 3-Sulfinopyruvate
has only substance units: false
is: CHEBI:1665

metaM 5fthf c
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01562
name: 5-formyltetrahydrofolate(2-)
initial amount: NaN
is: CHEBI:57457
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_98daf586_0916_4bff_9d8a_c9f325e209fd
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA177072
constant: false
initial amount: NaN
is: SBO:0000252
name: _AA177072_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_a6804298_3e0d_4203_8d85_de5433abc4ab
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:84532
boundary condition: true
is: Q9NUB1
is: SBO:0000252
name: ACSS1
has only substance units: false

metaR RE3326M
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
reversible: true
name: RE3326
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
type: Reaction

metaR r0629
product: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.6.1.22
fast: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is: SBO:0000176
reversible: true
type: Reaction

metaM tdchola e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
is: CHEBI:9407
name: taurochenodeoxycholate
constant: false
is: SBO:0000247
is: HMDB00951
has only substance units: false
boundary condition: false

metaR RE2759X
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
is version of: http://identifiers.org/ec-code/5.1.99.4
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
name: RE2759
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false

metaM gbside hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: globoside
initial concentration: 1.0
is: CHEBI:18259

metaR r0821
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR HRETNtn
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
name: 4-hydroxyretinoic acid transport, Nuclear
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_9251fd43_2bb9_41c0_9ad3_42c16890fe03
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: B4E3E9
is encoded by: hsa:4967
name: OGDH
boundary condition: true

metaM dolglcp L r
is: CHEBI:15812
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_9440ddcf_8c7e_495e_81cb_fc506c609016
initial amount: NaN
is encoded by: hsa:6532
has only substance units: false
initial concentration: NaN
type: Species
is: P31645
name: SLC6A4
constant: false
is: SBO:0000252
boundary condition: true

metaM etfrd m
is: HMDB00151
is: CHEBI:16469
boundary condition: false
name: Electron transfer flavoprotein reduced
initial amount: NaN
type: Species
constant: false
notes: FORMULA: RH2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM chsterol r
boundary condition: false
name: cholesterol
is: SBO:0000247
initial amount: NaN
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
has only substance units: false
is: CHEBI:16113
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_2359ad1f_9616_485c_835b_5e88092666f5
is encoded by: hsa:6241
is: P31350
initial concentration: NaN
name: RRM2
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaR P4502D6
kinetic law: MODEL1310110050#
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.14.1
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
name: cytochrome P450 2D6
notes: GENE_ASSOCIATION: (1565.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES:debrisoquine 4-hydroxylation assumed to take place on outer membrane NJ
product: MODEL1310110050#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_7981529f_b777_4121_a6dc_507b30395718
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4716
initial amount: NaN
constant: false
is: A8K761
name: NDUFB10
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_d058c9e5_ca95_456e_9513_58c13cc8d076
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7498
name: XDH
initial amount: NaN
is: P47989
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR r2372
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000

metaR DAGK hs
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.1.107
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_0d7d9e17_55da_4820_aa48_cb1dfb217bbd
initial concentration: NaN
is encoded by: hsa:54511
initial amount: NaN
name: HMGCLL1
has only substance units: false
type: Species
is: Q9NT06
boundary condition: true
constant: false
is: SBO:0000252

metaR r1448
is: SBO:0000176
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reversible: false
product: MODEL1310110050#
name: EC:1.3.3.6
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_ff489810_197f_4924_8d8a_551aef4f43cb
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AI656480
is: SBO:0000252
name: _AI656480_1_m
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_93680f8f_1e26_4bfc_95a1_3cd05fce436c
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2629
type: Species
is: SBO:0000252
name: GBA
has only substance units: false
is: B7Z6S1

metaR 3SALAOX
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: cysteinesulfinic acid oxidase
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_7d5c1a84_0c21_40b8_b0ad_073363d3c97c
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: ACLY
is encoded by: hsa:47
type: Species
is: P53396
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_858aeef5_6fb0_4d1d_bc8a_ff14a3309bc1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2876
constant: false
initial concentration: NaN
boundary condition: true
name: GPX1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_691c2be3_b717_429c_ac87_66c179c9cc20
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:AI697028
initial concentration: NaN
initial amount: NaN
name: _AI697028_1_e
is: SBO:0000252
type: Species

metaM gp1calpha hs g
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
boundary condition: false
has only substance units: false
is: CHEBI:58121
type: Species
is: HMDB00618
constant: false
name: GP1c alpha

metaR r2371
type: Reaction
kinetic law: MODEL1310110050#
reversible: true
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR RE0944E
reactant: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0944
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110050#
is: SBO:0000176

metaR r0936
reactant: MODEL1310110050#
reversible: false
name: Transport reaction
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#

metaR r2374
is: SBO:0000185
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_830ad350_bfe6_4236_b03f_61629a6846a2
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: NME6
is encoded by: hsa:10201
is: O75414
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_b4415c34_cf7c_4aab_98e8_ea132ba2a470
constant: false
boundary condition: true
is encoded by: hsa:522
name: ATP5J
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P18859

http://identifiers.org/biomodels.db/MODEL1310110050#_76681957_944b_46d7_9be9_d7d71f189318
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8399
constant: false
is: O15496
name: PLA2G10
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_c76bea4f_a6e7_44c4_b0d7_44849496c345
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O95498
name: VNN2
is encoded by: hsa:8875

metaR THFtm
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
product: MODEL1310110050#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reactant: MODEL1310110050#
type: Reaction

metaR r0822
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110050#_eabb302c_75a5_4140_8534_e479579152b8
initial concentration: NaN
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
has part: F8W7V3
initial amount: NaN
type: Species
constant: false
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:517

metaR r0497
fast: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is: SBO:0000176

metaR THYMt
is: SBO:0000185
is described by: ECO:0000269
fast: false
modifier: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: thymine reversible transport via facilated diffusion

metaR r2373
kinetic law: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
is: SBO:0000185
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM gp1calpha hs e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
boundary condition: false
is: SBO:0000247
is: CHEBI:58115
is: HMDB01397
type: Species
name: GP1c alpha
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_97cfbfd5_6dda_4c8e_b4a4_90e06980d3a1
type: Species
boundary condition: true
name: ADCY7
is: SBO:0000252
is: P51828
initial concentration: NaN
has only substance units: false
is encoded by: hsa:113
initial amount: NaN
constant: false

metaM lnlnca e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
has only substance units: false
constant: false
is: CHEBI:32387
initial concentration: 1.0
boundary condition: false
name: alpha-linolenate
is: HMDB01388
type: Species

metaR r1298
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110050#
fast: false
type: Reaction
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false

metaM sl L c
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
name: (S)-3-sulfonatolactate(2-)
is: CHEBI:61289
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_59ecfda0_8d54_4611_b999_4dcddcecd60d
is encoded by: hsa:5291
is: B4DER4
type: Species
initial concentration: NaN
name: PIK3CB
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_f7a4aafb_aade_4c0b_9b9a_c345a5391e04
boundary condition: true
name: SLC14A2
constant: false
initial concentration: NaN
initial amount: NaN
is: Q15849
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8170
type: Species

metaR r1587
reactant: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
type: Reaction

metaR COAtm
modifier: MODEL1310110050#
fast: false
product: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110050#
reversible: true
type: Reaction
name: CoA transporter
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_a2ea405f_5a5f_4dd3_9715_0ae423d30357
constant: false
is encoded by: hsa:3028
boundary condition: true
is: Q99714
name: HSD17B10
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaR r1299
fast: false
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_5435b506_edbd_46ef_a065_7e3ede992275
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:217
initial amount: NaN
constant: false
is: P05091
name: ALDH2
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_57f16806_05f1_4443_99e8_e575bf7220af
initial concentration: NaN
name: COX6B2
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:125965
is: Q6YFQ2
boundary condition: true
is: SBO:0000252

metaR r1588
is: SBO:0000185
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_fcd1f799_4ce4_4545_bec0_396930548542
is: SBO:0000252
name: SLC40A1
is encoded by: hsa:30061
is: Q9NP59
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaM gt3 hs g
boundary condition: false
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
constant: false
initial amount: NaN
initial concentration: 1.0
name: GT3
type: Species
is: SBO:0000247
is: CHEBI:28424
has only substance units: false

metaR COAtl
name: CoA transport in lysosome via diffusion
reversible: true
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT

metaR TYRt
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
fast: false
type: Reaction
name: L-tyrosine transport
is: SBO:0000185
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110050#_d4e0a7ab_1704_40d6_9008_8e1f14ac1ddb
boundary condition: true
is encoded by: hsa:7296
name: TXNRD1
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q16881

metaR C6DCCACT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaM lnlnca c
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: alpha-linolenate
is: CHEBI:32387
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-

http://identifiers.org/biomodels.db/MODEL1310110050#_4ec7b853_68aa_4589_bb34_b41774d2fa45
is encoded by: hsa:56994
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: CHPT1
is: Q8WUD6
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM sl L e
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
name: (S)-3-sulfonatolactate(2-)
is: CHEBI:61289
initial amount: NaN
constant: false
is: SBO:0000247

metaM gm1b hs g
notes: FORMULA: C55H95N3O30FULLRCO CHARGE: -1
boundary condition: false
constant: false
initial concentration: 1.0
name: GM1b
has only substance units: false
is: CHEBI:15440
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00256

metaR B3GALT41g
is described by: ECO:0000269
reactant: MODEL1310110050#
name: Beta-1,3-galactosyltransferase 4
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.62
product: MODEL1310110050#
reversible: false

metaR r1585
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR r1854
kinetic law: MODEL1310110050#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
fast: false
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR C14STRr
is version of: http://identifiers.org/ec-code/1.3.1.70
name: C-14 sterol reductase
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
product: MODEL1310110050#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_42bd1376_7320_45fe_a85e_22f0cc7bd944
initial concentration: NaN
is: SBO:0000252
name: GGH
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:8836
is: Q92820
constant: false

metaR PItg
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: false
type: Reaction
name: phosphate transport, Golgi apparatus
reactant: MODEL1310110050#
fast: false

metaR OCD11CRNCPT2
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM dadp c
boundary condition: false
has only substance units: false
is: CHEBI:57667
initial amount: NaN
is: C00206
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
name: dADP

metaR PHCDm
is: SBO:0000176
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
reversible: false
is described by: ECO:0000304
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
reactant: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction

metaR r1586
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaM HC02149 c
is: SBO:0000247
is: CHEBI:28867
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial amount: NaN
boundary condition: false
name: O-Propanoylcarnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_76861a88_9990_4a59_b9d1_05ae321ff8a9
initial concentration: NaN
boundary condition: true
is: O43272
constant: false
has only substance units: false
is encoded by: hsa:5625
type: Species
is: SBO:0000252
name: PRODH
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_c21b49c9_3217_4efc_a565_908beeda9883
is encoded by: hsa:51227
is: SBO:0000252
type: Species
initial concentration: NaN
name: PIGP
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaM hs deg17 l
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:21338
is: SBO:0000247
initial concentration: 1.0
is: HMDB02704
name: heparan sulfate, degradation product 17
constant: false
initial amount: NaN
notes: FORMULA: C43H65N2O48S4 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110050#_e97f9637_f623_4725_a104_59f590cc64c9
initial concentration: NaN
is: E5KNH5
type: Species
boundary condition: true
initial amount: NaN
name: NDUFV1
is encoded by: hsa:4723
is: SBO:0000252
constant: false
has only substance units: false

metaM r5p c
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: C00117
boundary condition: false
is: HMDB00618
has only substance units: false

metaM 4aphdob c
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:58147
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978
type: Species

metaM malthp e
constant: false
boundary condition: false
initial concentration: 1.0
is: C01936
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
type: Species
initial amount: NaN
is: SBO:0000247
name: maltoheptaose

metaR TRPO2
is described by: ECO:0000269
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
reversible: false
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.13.11.11
fast: false
is: SBO:0000176
product: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_91287efd_8a32_49f9_a815_e98df225c078
is: SBO:0000252
type: Species
is encoded by: hsa:7296
has only substance units: false
name: TXNRD1
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_aac2ed8a_9fb1_46f2_8d32_31e2630884c1
name: ST3GAL3
is encoded by: hsa:6487
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: B4DX62
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_081a865c_8246_48fc_8123_a0fb25dd7616
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: SLC7A6
boundary condition: true
is: Q92536
is encoded by: hsa:9057
is: SBO:0000252

metaR CO2ter
type: Reaction
reversible: true
product: MODEL1310110050#
fast: false
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 endoplasmic reticular transport via diffusion
is described by: ECO:0000000

metaR UDPDOLPT L
is: SBO:0000176
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.117
reversible: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
fast: false
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
type: Reaction

metaM thbpt4acam n
constant: false
type: Species
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:15374

metaR AHCYSte
kinetic law: MODEL1310110050#
is described by: ECO:0000134
name: Transport of S-adenosyl-L-homocysteine
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110050#
is: SBO:0000185
type: Reaction
reversible: true
fast: false

metaM gly m
boundary condition: false
is: CHEBI:15428
type: Species
name: Glycine
constant: false
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
is: HMDB00123
initial concentration: 1.0
initial amount: NaN
is: C00037

metaR HOXG
reactant: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
name: Heme oxygenase 1
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
product: MODEL1310110050#
is described by: ECO:0000134
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.14.99.3
type: Reaction
is: SBO:0000176
fast: false

metaM HC01223 m
initial amount: NaN
is: CHEBI:57340
boundary condition: false
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047

metaR COAtp
is: SBO:0000185
name: coenzyme A transport, peroxisomal
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110050#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_05304c7a_e1f4_491b_8174_b262fdf93144
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:10050
initial amount: NaN
name: SLC17A4
has only substance units: false
initial concentration: NaN
is: Q9Y2C5
constant: false

metaR PGCD
reversible: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
type: Reaction
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000269
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.95
reactant: MODEL1310110050#
name: phosphoglycerate dehydrogenase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_82fb13f9_f4a4_47d0_8d0f_a4213fb48d96
is: SBO:0000252
constant: false
is encoded by: hsa:1595
name: CYP51A1
boundary condition: true
initial amount: NaN
is: Q16850
has only substance units: false
type: Species
initial concentration: NaN

metaM succoa x
boundary condition: false
constant: false
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01022
initial concentration: 1.0

metaR RE2541E
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
reversible: true
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
name: RE2541
fast: false
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000176

metaR C101CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaR GLCAASE5ly
name: beta-glucuronidase, lysosomal
reversible: false
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR CDIPTr
name: phosphatidylinositol synthase (Homo sapiens)
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.8.11
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
type: Reaction
reversible: true

metaM ade e
boundary condition: false
name: adenine
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00034
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: CHEBI:16708
has only substance units: false
initial amount: NaN

metaR PROSTGF2t
reversible: true
is: SBO:0000185
modifier: MODEL1310110050#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
name: prostaglandin uniport

metaR SIAT4Bg
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110050#
reversible: false

metaM dcacoa c
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
has only substance units: false
is: C05274
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
initial amount: NaN
constant: false

metaR AHCYStd
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110050#
is: SBO:0000185
name: diffusion of S-Adenosyl-L-homocysteine
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
reversible: true

metaR DRPA
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
product: MODEL1310110050#
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_04f49482_1e7a_4709_9b42_9378a0c4e8aa
is encoded by: hsa:159963
is: Q1EHB4
initial concentration: NaN
constant: false
name: SLC5A12
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR ILETA
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110050#
is described by: ECO:0000269
name: isoleucine transaminase
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_15a96bca_4da2_4f26_93e4_214b017a4e7c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: O75355
name: ENTPD3
is encoded by: hsa:956
constant: false
has only substance units: false

metaR r1589
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_034cd454_87fb_473f_a94b_075c08e68d8c
boundary condition: true
type: Species
constant: false
is: P51648
is encoded by: hsa:224
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ALDH3A2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_dbcbbbbb_d9b0_4240_8c1b_f64d58bfcdfc
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: SCP2
initial amount: NaN
constant: false
is encoded by: hsa:6342
has only substance units: false
is: C9JC79

metaR FUCASEe
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
reversible: false
name: alpha-fucosidase, extracellular
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.51
reactant: MODEL1310110050#

metaR RE1903R
is: SBO:0000176
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
fast: false
name: RE1903
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_7dad5f04_255d_406d_be95_ce9e08bd353b
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CA4
is: SBO:0000252
is encoded by: hsa:762
constant: false
has only substance units: false
type: Species
is: Q6FHI7

metaR RE3626M
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: RE3626
reactant: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#

metaR OCDCEAtr
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_c32604ee_e465_46da_bcd8_c036ac51a1e3
initial concentration: NaN
is encoded by: hsa:2592
has only substance units: false
is: E7ET32
is: SBO:0000252
name: GALT
initial amount: NaN
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_25a5c14f_0785_413d_84b7_7c87fa9d7995
is: P35219
name: CA8
initial concentration: NaN
has only substance units: false
is encoded by: hsa:767
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

metaR r1851
is: SBO:0000185
modifier: MODEL1310110050#
reversible: false
fast: false
kinetic law: MODEL1310110050#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#

metaR C3DCe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR COAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110050#
name: coenzyme A transport, nuclear
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_99852fa9_939d_4fca_9183_197ac7ac10cc
is encoded by: hsa:622
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: BDH1
initial amount: NaN
constant: false

metaM ksi pre27 g
boundary condition: false
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 27
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06552
is: CHEBI:2504
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_cf0f64b8_a801_40d4_abe9_4f1837cb128f
is: Q9NRZ5
name: AGPAT4
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:56895
is: SBO:0000252
initial amount: NaN

metaM ade c
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00147
type: Species
is: SBO:0000247
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
name: Adenine
is: HMDB00034
has only substance units: false
is: CHEBI:16708

metaM CE2421 m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: HMDB02329
has only substance units: false
constant: false
is: CHEBI:30623
type: Species
name: (3S)-3-hydroxylinoleoyl-CoA
initial amount: NaN

metaR NADS2
modifier: MODEL1310110050#
name: NAD synthase (glutamine-hydrolysing)
product: MODEL1310110050#
is: SBO:0000176
reversible: false
reactant: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.1
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000269

metaM g1m8masn r
notes: FORMULA: C76H127N2O60X CHARGE: 0
type: Species
is: C05875
constant: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM met L e
is: SBO:0000247
is: CHEBI:16643
is: HMDB00696
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false
name: L-methionine

metaR COt
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
name: CO transporter via diffusion
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_05e52e84_0378_4e80_8ae8_24439d52dc8b
constant: false
is: F8WDN9
boundary condition: true
has only substance units: false
is encoded by: hsa:27068
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: PPA2

metaR r1291
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110050#
name: Postulated transport reaction
product: MODEL1310110050#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_463a4986_f13b_4625_9db6_82bce8ea4472
constant: false
is encoded by: hsa:3295
is: SBO:0000252
name: HSD17B4
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: E9PB82

metaR FAOXC5C5DCc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_b6f3eebb_39ce_4222_8a7f_755ad0205985
name: PIGB
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9488
is: Q92521
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_832ac543_8d56_42c6_a4c5_ef125e38feb9
type: Species
name: SDHD
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6392
is: O14521
is: SBO:0000252
has only substance units: false

metaR RE1516M
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1516
reversible: true
fast: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_a0e62b90_c41c_4340_89a6_b30f6162ead2
has only substance units: false
constant: false
type: Species
is: O95907
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23539
name: SLC16A8

http://identifiers.org/biomodels.db/MODEL1310110050#_b0dd1d0a_7a7e_474c_a3d9_5c7fadd15490
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3712
type: Species
is: B3KVI7
name: IVD
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM ocdca c
initial concentration: 1.0
has only substance units: false
name: stearate
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00827
type: Species
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: SBO:0000247

metaR LEUKTRB4t
reversible: true
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
name: leukotriene B4 transport
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction

metaR PYDXPP
product: MODEL1310110050#
name: Pyridoxal 5-phosphate phosphatase
fast: false
kinetic law: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (57026.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14522954,PMID:6380540 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.3
reversible: false
is: SBO:0000176
reactant: MODEL1310110050#

metaR ACGAMK
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
type: Reaction
name: N-acetylglucosamine kinase
modifier: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.59
is: SBO:0000176
kinetic law: MODEL1310110050#

metaM ru5p D r
constant: false
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
type: Species
boundary condition: false
name: D-ribulose 5-phosphate(2-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:58121
has only substance units: false

metaR 4HDEBRISOQUINEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
name: xenobiotic transport
type: Reaction
fast: false

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR r1292
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110050#
name: Postulated transport reaction

metaM met L c
is: SBO:0000247
is: CHEBI:16643
type: Species
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: L-methionine
constant: false

metaM CE2705 c
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: CHEBI:57287
is: HMDB01423
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: quinonoid dihydrobiopterin
is: C00010
initial concentration: 1.0

metaR NACHEX9ly
kinetic law: MODEL1310110050#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000

metaR GASNASE2ly
is: SBO:0000176
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
name: glycosylasparaginase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.5.1.26

http://identifiers.org/biomodels.db/MODEL1310110050#_07a0b691_6fb2_47a0_a385_842d807047df
initial concentration: NaN
name: ACP2
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: E9PCI1
initial amount: NaN
has only substance units: false
is encoded by: hsa:53

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM dgsn e
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00330
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:17172
has only substance units: false
is: HMDB00085

metaR r0809
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110050#
name: Facilitated diffusion
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#

metaM succoa m
has only substance units: false
constant: false
boundary condition: false
is: HMDB01022
is: CHEBI:57292
is: SBO:0000247
type: Species
name: Succinyl-CoA
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091

metaR CYTK2
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP)
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110050#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_fdd0718e_3ee9_418c_9e09_fd8d976bc868
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9UBQ7
name: GRHPR
type: Species
is: SBO:0000252
is encoded by: hsa:9380

http://identifiers.org/biomodels.db/MODEL1310110050#_511255b3_fd01_43d6_8902_ad049409a43e
name: RDH5
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q92781
has only substance units: false
initial amount: NaN
is encoded by: hsa:5959

metaM lnlnca l
is: HMDB01388
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial concentration: 1.0
is: CHEBI:32387
name: alpha-linolenate
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_badfc096_1701_4c03_9d0f_3e1e92a8960e
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: P43007
name: SLC1A4
has only substance units: false
is encoded by: hsa:6509
is: SBO:0000252

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR FAOXC12C12OHm
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR COAtr
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reversible: true
fast: false
name: COA transporter, endoplasmic reticulum

metaM hmbil c
initial concentration: 1.0
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
constant: false
is: C01024
initial amount: NaN
type: Species
is: CHEBI:57845
boundary condition: false
is: SBO:0000247
is: HMDB01137
has only substance units: false
name: Hydroxymethylbilane

metaR CYTK1
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
name: cytidylate kinase (CMP)
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR PItn
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
name: phosphate transport, nuclear
reversible: true
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_acf3f3da_cf94_4d53_bc37_f3e21ef0af7d
constant: false
initial concentration: NaN
is encoded by: hsa:2348
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: FOLR1
has only substance units: false

metaR 3AIBt
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
name: 3-amino-isobutyrate transport
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_3559dec7_b445_4972_926d_d99895880b0f
initial concentration: NaN
has only substance units: false
is: P49915
type: Species
is: SBO:0000252
name: GMPS
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8833

metaR CYTK4
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
fast: false
type: Reaction
is: SBO:0000176
name: cytidylate kinase (dCMP)(GTP)
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_f1bf7d29_6d6d_4176_a6f0_a2e72f1c08d2
initial amount: NaN
name: NDUFA12
has only substance units: false
constant: false
is encoded by: hsa:55967
is: F8VQS7
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM dgsn c
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
initial amount: NaN
type: Species
boundary condition: false
name: Deoxyguanosine
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:17172
is: HMDB00085

http://identifiers.org/biomodels.db/MODEL1310110050#_a4a42d9d_e494_4e6e_8308_1a52c6691ead
boundary condition: true
is encoded by: hsa:1603
initial amount: NaN
has part: Q53G02
type: Species
has part: P04844
has part: P04843
is encoded by: hsa:6184
is encoded by: hsa:1650
is encoded by: hsa:6185
initial concentration: NaN
has only substance units: false
name: DAD1:DDOST:RPN1:RPN2
is: SBO:0000297
constant: false
has part: P39656

metaR r0360
type: Reaction
modifier: MODEL1310110050#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.16
reversible: false
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000176

metaR RETFAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
fast: false
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
name: fatty acid retinol efflux

metaR SEBACACT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaM xol7aone c
is: CHEBI:17899
initial concentration: 1.0
type: Species
is: HMDB01993
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

http://identifiers.org/biomodels.db/MODEL1310110050#_1ede9866_97a6_46f6_b758_a2a2143e34f0
is: P05187
boundary condition: true
name: ALPP
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:250

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM lnlnca r
boundary condition: false
is: CHEBI:32387
type: Species
is: SBO:0000247
is: HMDB01388
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
name: alpha-linolenate

metaR H2Ot
name: H2O transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false

metaR CYTK3
is described by: ECO:0000269
type: Reaction
name: cytidylate kinase (CMP)(GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_ab25b970_bb12_4da9_b54c_775f33f85344
name: GALNT6
has only substance units: false
is: Q8NCL4
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:11226
initial concentration: NaN
constant: false

metaR NDP8ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000269
reactant: MODEL1310110050#
modifier: MODEL1310110050#
name: nucleoside-diphosphatase (UTP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
product: MODEL1310110050#
reversible: false

metaM m4masn g
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C05881
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN

metaR TKT2
name: transketolase
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.2.1.1
product: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_92f2f50b_0273_4c0a_8976_5b73577f2a4a
is: O75452
boundary condition: true
name: RDH16
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:8608
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_e5c9cb23_8c42_4839_9100_6a4664947039
initial concentration: NaN
name: HK1
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: P19367
boundary condition: true
is encoded by: hsa:3098
initial amount: NaN

metaM mn l
is: HMDB06535
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: beta-1,4-mannose-N-acetylglucosamine
boundary condition: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_782f2813_d7f9_42f4_a01c_f2b65a931a97
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:BE966236
constant: false
name: _BE966236_1_m
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_8e19528d_686a_48b1_b454_bb7455508132
initial concentration: NaN
is encoded by: hsa:2589
has only substance units: false
initial amount: NaN
name: GALNT1
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: Q10472

http://identifiers.org/biomodels.db/MODEL1310110050#_4a302f2a_48a9_4342_9479_6f4ae6401fbb
is: Q9H6Y6
is: SBO:0000252
type: Species
is encoded by: hsa:4645
constant: false
name: MYO5B
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_cd0d1aa3_1b30_4a2c_bb72_68eb3a9676aa
boundary condition: true
is: SBO:0000252
is: F6KD01
initial concentration: NaN
constant: false
name: PTEN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5728

metaR RE2649C
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
type: Reaction
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110050#
modifier: MODEL1310110050#
name: RE2649
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2

metaM datp c
is: SBO:0000247
constant: false
is: C00131
is: HMDB01532
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial amount: NaN
is: CHEBI:61404
name: dATP
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR G12MT1 L
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_ea8390e7_c2df_497d_85ab_7eb844eb4778
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9H5J4
is: SBO:0000252
name: ELOVL6
boundary condition: true
is encoded by: hsa:79071
type: Species

metaR CYTK6
reversible: true
fast: false
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110050#
type: Reaction
name: cytidylate kinase (CMP,CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#

metaR TKT1
reversible: true
product: MODEL1310110050#
fast: false
type: Reaction
modifier: MODEL1310110050#
name: transketolase
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.2.1.1
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2

metaM gly x
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
is: HMDB00123
initial amount: NaN
name: glycine
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_1b3de333_c307_4c5a_b789_4464579ef7da
has part: Q8TBF5
is encoded by: hsa:93183
is encoded by: hsa:54965
has part: Q9H3S5
is: SBO:0000297
name: PIGX:PIGM
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_9eafd373_d6e7_40ea_8cca_e8045f0d3a88
is: SBO:0000252
name: ATP5F1
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:515
boundary condition: true
constant: false

metaM 7thf e
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB06559
notes: FORMULA: C49H57N13O24 CHARGE: -8
is: SBO:0000247
name: heptaglutamyl folate (THF)

metaR ACETONEt2m
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
name: acetone mitochondrial transport via proton symport

metaR OROTGLUt
reversible: true
is described by: ECO:0000134
name: OROTGLUt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaM ocdca e
is: SBO:0000247
is: C01530
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: HMDB00827
name: octadecanoate (n-C18:0)
boundary condition: false
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530

metaM acrn c
boundary condition: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57589
initial amount: NaN
name: O-acetylcarnitine
has only substance units: false
initial concentration: 1.0
is: HMDB00201

http://identifiers.org/biomodels.db/MODEL1310110050#_9c3a0676_7295_4831_859d_58eabd7681c3
initial concentration: NaN
name: SLC25A1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6576
constant: false
boundary condition: true
type: Species
has only substance units: false
is: D9HTE9

metaR CYTK5
name: cytidylate kinase (dCMP)
product: MODEL1310110050#
is: SBO:0000176
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110050#
type: Reaction

metaM chtn e
boundary condition: false
is: CHEBI:17029
initial amount: NaN
constant: false
name: chitin
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
type: Species
is: HMDB03362

metaR CYTK7
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: cytidylate kinase (CMP,UTP)
reactant: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_9e48ea24_50a8_4d2e_9020_0ff53aebd4d1
boundary condition: true
has part: B4DER4
is encoded by: hsa:5291
initial concentration: NaN
has part: B3KT19
constant: false
name: PIK3CB:PIK3R1
is: SBO:0000297
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5295

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_653fc450_e028_4324_81c6_b7790e4b5a26
boundary condition: true
name: SLC8A3
initial concentration: NaN
is encoded by: hsa:6547
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

metaM hom L e
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: L-homoserine
boundary condition: false
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
has only substance units: false
is: HMDB00719

http://identifiers.org/biomodels.db/MODEL1310110050#_bf5a9a57_6eee_44f0_b1df_0e5afce7d751
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PRDX1
is encoded by: hsa:5052
initial concentration: NaN
type: Species
initial amount: NaN

metaR r0068
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
fast: false
reversible: false
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.2.1

metaM dcacoa m
initial concentration: 1.0
name: Decanoyl-CoA (n-C10:0CoA)
is: SBO:0000247
initial amount: NaN
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
is: HMDB06404
is: CHEBI:61430
constant: false
type: Species
boundary condition: false

metaM succoa c
has only substance units: false
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: Succinyl-CoA
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_c9649dce_a163_4da3_8dd9_593cca5e3b7f
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9197
is: O00400
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SLC33A1
is: SBO:0000252

metaM gln L e
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
is: CHEBI:18050
type: Species
has only substance units: false
initial concentration: 1.0
name: L-glutamine
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00641

metaR CYTK8
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
fast: false
is described by: ECO:0000269
name: cytidylate kinase (CMP,dATP)
product: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110050#

metaR ST8SIA53g
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110050#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110050#
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110050#

metaR GALtly
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: galactose efflux from lysosome
is: SBO:0000185
reversible: false
reactant: MODEL1310110050#
product: MODEL1310110050#

metaR CYTK1n
fast: false
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r2389
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction

metaR r1434
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
name: Transport reaction
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000185

metaR r0330
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
reactant: MODEL1310110050#
product: MODEL1310110050#

metaR ACOAO7p
is described by: ECO:0000269
kinetic law: MODEL1310110050#
reversible: false
is: SBO:0000176
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_72568c92_b205_4111_aa93_5dc4b15d43ec
boundary condition: true
initial amount: NaN
is encoded by: hsa:4694
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFA1
is: SBO:0000252
is: Q6IBB5
constant: false

metaM gly c
is: HMDB00123
type: Species
has only substance units: false
name: Glycine
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:3339
is: C00037
initial concentration: 1.0
initial amount: NaN
constant: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaR CYTK1m
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
product: MODEL1310110050#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
is: SBO:0000176
fast: false
name: cytidylate kinase (CMP),mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110050#_37462bb5_71e9_43b3_8c58_83f75112b56c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1109
type: Species
boundary condition: true
name: AKR1C4
is: P17516
has only substance units: false
initial concentration: NaN
constant: false

metaR CYTK9
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP)
fast: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110050#
type: Reaction

metaM hom L c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00719
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
type: Species
name: L-homoserine
boundary condition: false
is: SBO:0000247
constant: false

metaM HC00229 e
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
has only substance units: false
name: Isomaltose
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:28189

metaR r0813
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:

metaR r2388
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
modifier: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110050#
is described by: ECO:0000000
reversible: false
type: Reaction

metaM ha e
constant: false
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: hyaluronan
initial amount: NaN
is: CHEBI:16336

metaR 3MOBt2im
is described by: ECO:0000000
type: Reaction
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM gln L c
has only substance units: false
name: L-glutamine
type: Species
initial concentration: 1.0
is: CHEBI:18050
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaM dgsn m
is: C00330
boundary condition: false
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false
has only substance units: false
is: HMDB00085
is: SBO:0000247
name: Deoxyguanosine
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_be3580f5_5115_435e_9d18_b5cdd6ce35f0
has only substance units: false
constant: false
boundary condition: true
name: NDUFB1
initial amount: NaN
is: O75438
is encoded by: hsa:4707
initial concentration: NaN
is: SBO:0000252
type: Species

metaR ATP2ter
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
name: AMP/ATP transporter, endoplasmic reticulum
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR r2387
type: Reaction
modifier: MODEL1310110050#
fast: false
product: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000

metaM acgam l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00215
type: Species
is: SBO:0000247
constant: false
name: N-acetyl-D-glucosamine
initial concentration: 1.0
is: CHEBI:17411

http://identifiers.org/biomodels.db/MODEL1310110050#_abc546be_25c0_46c6_84c2_0a155be38333
constant: false
type: Species
is encoded by: hsa:AD000092
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AD000092_1_c

metaR r0812
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
reactant: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_f8ae35bb_ac37_413a_ac3a_ad88cda38ab0
is: SBO:0000252
initial concentration: NaN
is: Q8TEQ8
boundary condition: true
type: Species
name: PIGO
has only substance units: false
initial amount: NaN
is encoded by: hsa:84720
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_0af5b7f6_b35c_4a0d_9ef3_d55aa9bf7481
initial amount: NaN
boundary condition: true
is encoded by: hsa:130367
type: Species
initial concentration: NaN
has only substance units: false
name: SGPP2
is: Q8IWX5
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_d681455d_bcfc_4679_ad28_b0ae7a6539b9
type: Species
boundary condition: true
is encoded by: hsa:83530
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: _83530_1_c

metaR r0354
product: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
initial amount: NaN
is: CHEBI:57667
boundary condition: false
initial concentration: 1.0
is: HMDB01508
is: SBO:0000247
type: Species
name: dADP(3-)
constant: false

metaR C10DCCACT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_8895c7d1_fc69_4a1b_9cd8_8e2c62da14c6
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: O95470
name: SGPL1
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:8879

metaM acrn m
is: CHEBI:57589
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: O-acetylcarnitine
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial concentration: 1.0
is: HMDB00201
has only substance units: false
type: Species
constant: false

metaR r0355
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
product: MODEL1310110050#
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaR HDDACBP
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR H2Otg
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
name: H2O transport, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110050#

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM dadp n
initial amount: NaN
is: CHEBI:57667
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: dADP(3-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_ff49f784_4e12_4722_9626_51c41103919f
has part: E9KL44
is: SBO:0000297
type: Species
initial amount: NaN
is encoded by: hsa:3032
has only substance units: false
has part: P55084
name: HADHA:HADHB
constant: false
is encoded by: hsa:3030
boundary condition: true
initial concentration: NaN

metaR r0819
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110050#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR TREHe
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.28
reactant: MODEL1310110050#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
name: alpha,alpha-trehalase
product: MODEL1310110050#
modifier: MODEL1310110050#

metaR MTHFTe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of THF into the protal blood
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_cb5ef27c_f025_4bce_bf17_1f71721be141
is: SBO:0000252
constant: false
type: Species
is: E7EPT3
name: ALDH7A1
boundary condition: true
is encoded by: hsa:501
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM n2m2nm l
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06529
boundary condition: false
name: n2m2nmasn (w/o peptide linkage)
is: CHEBI:50570
type: Species
notes: FORMULA: C58H97N5O41 CHARGE: 0
initial amount: NaN
constant: false

metaM fald c
is: HMDB01426
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde
is: SBO:0000247
is: CHEBI:16842
initial amount: NaN
boundary condition: false
type: Species

metaM oaa c
is: HMDB00223
is: C00036
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Oxaloacetate
is: SBO:0000247
notes: FORMULA: C4H2O5 CHARGE: -2
is: CHEBI:3338
type: Species
initial amount: NaN
constant: false

metaM Rtotalcoa c
is: HMDB01448
initial concentration: 1.0
name: R total Coenzyme A
has only substance units: false
is: SBO:0000247
is: CHEBI:16189
initial amount: NaN
constant: false
type: Species
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
boundary condition: false

metaR EX tdcrn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR DM gncore2 g
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gncore2(g)
type: Reaction

metaR r0818
fast: false
name: Transport reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaR GTHP
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000134
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.11.1.9
is version of: http://identifiers.org/ec-code/1.11.1.12
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD

metaM HC00718 c
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57781
is: SBO:0000247
boundary condition: false
type: Species
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_33be5345_3665_4ed6_9162_a5e6bb45438c
is: SBO:0000252
name: NDUFV2
is: P19404
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4729
type: Species
initial concentration: NaN
constant: false

metaR r0331
kinetic law: MODEL1310110050#
reversible: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaM acetol c
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:27957
initial concentration: 1.0
name: hydroxyacetone
is: HMDB06961
constant: false
initial amount: NaN
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3

metaR r0618
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110050#
reversible: true
is: SBO:0000176
product: MODEL1310110050#
type: Reaction
fast: false

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR r0817
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110050#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
reversible: true

metaR ACACt2m
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110050#
name: Acetoacetate mitochondrial transport via H+ symport
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_1d69a7fb_5249_4e34_87f7_2f23a3a40d98
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: ACSL4
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2182
boundary condition: true
is: Q5JWV8

metaM nadp c
is: CHEBI:58349
constant: false
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
type: Species
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
initial concentration: 1.0
is: C00006
is: HMDB00217
initial amount: NaN

metaR RE0958E
is described by: ECO:0000000
reactant: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0958

metaM ksi pre26 g
initial concentration: 1.0
constant: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 26
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_e8b233f6_77dd_40cb_9f1f_92c5647f9570
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: _AA021081_1_r
constant: false
is encoded by: hsa:AA021081

metaR ALOX52
product: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
reversible: false
name: Arachidonate 5-lipoxygenase
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.13.11.34
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is: SBO:0000176
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000269

metaM pail5p hs c
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM etoh e
name: ethanol
type: Species
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16236
initial concentration: 1.0
constant: false
is: HMDB00108
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_1a7080d4_f4c9_4eee_93d6_f8615976dcbb
is encoded by: hsa:229
initial amount: NaN
type: Species
name: ALDOB
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P05062
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_3356011a_8de2_4fa1_815f_f152bf3e8d69
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:518
is: P48201
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ATP5G3

http://identifiers.org/biomodels.db/MODEL1310110050#_17697642_34fe_4c1b_bbae_bda517bef7fb
is encoded by: hsa:111
boundary condition: true
has only substance units: false
is: O95622
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: ADCY5
constant: false

metaR r0616
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110050#
product: MODEL1310110050#
fast: false

metaR RE1810M
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
name: RE1810
is: SBO:0000176
product: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_b6355c5b_110e_4489_ada2_30d173cf27b6
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: GUK1
is encoded by: hsa:2987
has only substance units: false
initial concentration: NaN
is: Q16774
constant: false

metaM dag hs c
name: diglyceride
constant: false
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:18035
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM datp n
constant: false
initial amount: NaN
name: dATP
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
is: CHEBI:61404
is: HMDB01532
is: C00131

http://identifiers.org/biomodels.db/MODEL1310110050#_8e94c8fa_0d4a_481b_9000_8ebbbbccc394
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI440329
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: _AI440329_1_r

metaR r1592
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaR r2382
modifier: MODEL1310110050#
type: Reaction
fast: false
kinetic law: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5f672c41_ea51_4fa9_a95b_009e4021271e
type: Species
is: O00476
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:10786
name: SLC17A3
initial amount: NaN

metaM nadp m
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
constant: false
has only substance units: false

metaM nrpphr e
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: CHEBI:33569
name: Norepinephrine
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00216

metaM acrn r
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
has only substance units: false
initial amount: NaN
is: CHEBI:57589
is: SBO:0000247
name: O-acetylcarnitine
constant: false
type: Species

metaM datp m
is: C00131
is: CHEBI:61404
constant: false
initial amount: NaN
is: HMDB01532
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
name: dATP
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f328d18b_1c10_423b_8c17_54907b071baf
is encoded by: hsa:56848
is: Q9NRA0
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SPHK2

http://identifiers.org/biomodels.db/MODEL1310110050#_fad6df08_90e3_43cd_a8a4_d274f234ba04
constant: false
is: SBO:0000252
name: _AI222095_1_e
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI222095
initial concentration: NaN
type: Species

metaR r1591
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_4f2e06b9_4342_4f4d_a36e_01a3f66cdd4f
initial amount: NaN
has only substance units: false
boundary condition: true
name: ACO1
initial concentration: NaN
is encoded by: hsa:48
type: Species
is: SBO:0000252
constant: false
is: P21399

http://identifiers.org/biomodels.db/MODEL1310110050#_fe1bef0b_4f69_4536_857c_69dec435bc7b
constant: false
name: CHAT
initial concentration: NaN
is: Q6LEN5
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1103
initial amount: NaN

metaR r0926
is: SBO:0000185
name: Postulated transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
product: MODEL1310110050#
type: Reaction
fast: false

metaM Tn antigen l
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: Tn antigen
notes: FORMULA: C8H14NO5X CHARGE: 0
is: C04383
has only substance units: false

metaR r0614
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
is: SBO:0000176
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_9354bcd9_edd8_4f66_bb90_d7590b456b39
name: LCT
initial amount: NaN
boundary condition: true
is: P09848
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3938
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_052f127f_6293_461c_b265_014c8f0f0e31
name: PGAP1
type: Species
has only substance units: false
is: Q75T13
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:80055
is: SBO:0000252

metaM sphgn c
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00269
initial concentration: 1.0
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
is: CHEBI:57817
name: sphinganine(1+)

metaM gsn c
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
type: Species
is: SBO:0000247
is: C00387
is: CHEBI:16750
boundary condition: false
is: HMDB00133
has only substance units: false
name: Guanosine

metaR ACACT1rm
type: Reaction
reversible: true
product: MODEL1310110050#
modifier: MODEL1310110050#
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
fast: false
kinetic law: MODEL1310110050#

metaM ru5p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
type: Species
is: HMDB00618
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58121
boundary condition: false

metaR r2380
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110050#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110050#

metaM xol7aone m
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01993
type: Species
is: SBO:0000247
is: CHEBI:17899
initial amount: NaN

metaR PI4P3K
is version of: http://identifiers.org/ec-code/2.7.1.154
name: phosphatidylinositol 4-phosphate 3-kinase
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
reactant: MODEL1310110050#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
is described by: ECO:0000000

metaM n2m2nmn l
is: CHEBI:17588
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: HMDB00742
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)

metaM oaa m
boundary condition: false
name: Oxaloacetate
is: SBO:0000247
is: C00036
initial amount: NaN
is: HMDB00223
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16452
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
constant: false

metaM mi14p n
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
constant: false
initial concentration: 1.0
is: HMDB00968
is: CHEBI:58282

metaR ADNt
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
name: adenosine facilated transport in cytosol
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110050#
fast: false
reversible: true

metaR FAOXC1811603m
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110050#
is: SBO:0000176
reversible: false
modifier: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction

metaM nrpphr c
is: HMDB00216
is: CHEBI:33569
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
name: Norepinephrine

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_27ed6d54_09f6_44d1_90f5_036063eddec1
is: Q15111
constant: false
name: PLCL1
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:5334
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_c69c4aa3_82f3_4d78_99d8_72f640d861f7
type: Species
name: RRM1
initial amount: NaN
boundary condition: true
is encoded by: hsa:6240
has only substance units: false
is: P23921
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_a6f48348_c186_446a_9689_85b7913367b6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:514
has only substance units: false
constant: false
name: ATP5E

http://identifiers.org/biomodels.db/MODEL1310110050#_fae431e0_fee8_4097_ac94_9f6e0a629e1b
initial amount: NaN
is encoded by: hsa:210
is: P13716
boundary condition: true
is: SBO:0000252
name: ALAD
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaR DHFR
modifier: MODEL1310110050#
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000254
name: dihydrofolate reductase
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#

metaR C12DCACT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

metaM fru c
is: CHEBI:15824
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: D-Fructose
is: HMDB00660
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
is: C00095
initial amount: NaN
constant: false

metaR SPHK21c
modifier: MODEL1310110050#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110050#
name: sphingosine kinase 2
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.1.91
is: SBO:0000176
product: MODEL1310110050#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f8d7c1ea_c78e_42e3_99f7_b1af3b0f1ffd
type: Species
constant: false
is encoded by: hsa:160287
name: LDHAL6A
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q6ZMR3
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_5e8f1399_c906_426b_a90f_88b75eb4bcdb
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: O00154
name: ACOT7
is encoded by: hsa:11332
constant: false
initial amount: NaN
initial concentration: NaN

metaR EX tetdec2crn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaR r1596
reactant: MODEL1310110050#
fast: false
type: Reaction
kinetic law: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

metaM crvnc c
notes: FORMULA: C22H31O2 CHARGE: -1
constant: false
has only substance units: false
is: CHEBI:36005
type: Species
is: HMDB02183
initial concentration: 1.0
name: cervonic acid, C22:6 n-3
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r2386
modifier: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_36998c1c_4515_4088_a8e9_2ed2219dccc5
type: Species
initial concentration: NaN
is encoded by: hsa:MBOAT5
constant: false
boundary condition: true
name: _MBOAT5_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM nformanth c
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: N-formylanthranilate
notes: FORMULA: C8H6NO3 CHARGE: -1 INCHI: InChI=1S/C8H7NO3/c10-5-9-7-4-2-1-3-6(7)8(11)12/h1-5H,(H,9,10)(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC01553 EHMN_ABBREVIATION: C05653
initial concentration: 1.0
is: SBO:0000247
is: HMDB04089
type: Species
is: CHEBI:18410

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM gly e
is: C00037
is: HMDB00123
initial concentration: 1.0
initial amount: NaN
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
constant: false
name: Glycine
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_9120fede_4944_4c09_b0e6_6b681ed72657
initial concentration: NaN
is encoded by: hsa:221
name: ALDH3B1
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: P43353
boundary condition: true

metaR H2Otp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
name: H2O transport, peroxisomal
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110050#

metaR H2Otn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110050#
fast: false
name: H2O transport, nuclear
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

metaR CORE6GTg
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
type: Reaction
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
is: SBO:0000176
reactant: MODEL1310110050#
fast: false

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaR RTOTALt
name: RTOTAL transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110050#

metaM CE5132 c
is: SBO:0000247
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:57923
initial amount: NaN

metaM acgam r
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
is: HMDB00215
constant: false
type: Species
name: N-acetyl-D-glucosamine

metaR r2385
type: Reaction
reversible: false
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaR r1595
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_523bdb31_79fb_41a9_bb3b_73c2cdd02ccd
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:522
name: ATP5J
constant: false
is: SBO:0000252

metaR B3GALT5g
reactant: MODEL1310110050#
modifier: MODEL1310110050#
name: Beta-1,3-galactosyltransferase 5
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110050#_bab9ea53_85b3_4f2b_9dc5_26d5ff39cfbd
constant: false
is encoded by: hsa:AI480132
is: SBO:0000252
has only substance units: false
name: _AI480132_1_c
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_a4bb3b0a_1579_42aa_a13c_ad30992b7192
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10317
name: B3GALT5
type: Species
initial amount: NaN
initial concentration: NaN

metaM xol7aone r
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01993
is: CHEBI:17899
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_707e3812_7895_46d9_a861_aa3d5eb7d32b
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:953
is: SBO:0000252
name: ENTPD1
constant: false
is: Q86VV3

metaR r0339
reactant: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.22
kinetic law: MODEL1310110050#

metaR H2Otm
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269
type: Reaction
product: MODEL1310110050#
name: H2O transport, mitochondrial

metaM fru e
is: CHEBI:15824
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00660
is: C00095
name: D-Fructose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial amount: NaN
has only substance units: false
constant: false

metaR 5OXPROt
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-oxoprolinate
reactant: MODEL1310110050#
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_2deacaaf_3c30_4c53_aa97_f122bde617f1
type: Species
boundary condition: true
is: Q9HAB8
initial concentration: NaN
name: PPCS
is encoded by: hsa:79717
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r2497
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r1594
reactant: MODEL1310110050#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaM crvnc e
notes: FORMULA: C22H31O2 CHARGE: -1
is: CHEBI:36005
constant: false
is: HMDB02183
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: cervonic acid, C22:6 n-3
has only substance units: false
is: SBO:0000247

metaR NDP8
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110050#
reversible: false
fast: false
name: nucleoside-diphosphatase (dUDP)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110050#

metaM etoh c
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
boundary condition: false
is: HMDB00108
initial amount: NaN
is: CHEBI:16236
constant: false
name: ethanol
has only substance units: false

metaR r2384
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_1e0f9701_488a_45f6_89d8_fd6aaf8e0bb3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AV713053
is: SBO:0000252
name: _AV713053_1_m
boundary condition: true
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_ed06d2e3_9068_491c_9d5d_2c57e9271cfb
has only substance units: false
name: PAH
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P00439
type: Species
is encoded by: hsa:5053
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_8ab7252c_1e5c_4a19_b7ed_57f3d44f7769
is: SBO:0000252
name: _22305_2_c
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:22305
boundary condition: true
initial amount: NaN
has only substance units: false

metaM Tn antigen g
initial amount: NaN
name: Tn antigen
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C8H14NO5X CHARGE: 0
initial concentration: 1.0
is: C04383
boundary condition: false

metaR NDP10ex
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
name: nucleoside-diphosphatase (IDP), extracellular
reversible: false
kinetic law: MODEL1310110050#

metaR r1593
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
fast: false

metaM gdpmann c
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is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57527
boundary condition: false
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
is: HMDB01163
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_6ae557f5_7fe5_4cea_a3d9_cc91f7eddf15
constant: false
boundary condition: true
has only substance units: false
name: RPE
is encoded by: hsa:6120
initial concentration: NaN
type: Species
initial amount: NaN
is: Q53TV9
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_5997c510_44ce_4f2f_a450_0b578739818e
boundary condition: true
name: ACOX1
is: B4DK61
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_abdd33cb_0113_410c_a728_bb48e2b4bc94
is encoded by: hsa:56052
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9BT22
has only substance units: false
initial amount: NaN
type: Species
name: ALG1

metaR r0921
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_56de1f0d_634e_4e3c_b31d_1aa1bac97745
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:230
boundary condition: true
name: ALDOC
is: SBO:0000252
is: P09972
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_aa25344d_a4dd_4f42_bc5f_1016ed6d8570
is: SBO:0000252
has only substance units: false
is encoded by: hsa:27068
type: Species
is: F8WDN9
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: PPA2

metaR C50CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaM hs deg3 l
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
boundary condition: false
name: heparan sulfate, degradation product 3
is: CHEBI:16126
has only substance units: false

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR N4Tg
reversible: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
fast: false
is described by: ECO:0000000
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
product: MODEL1310110050#
is: SBO:0000176

metaR DOLP Lter
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
name: dolichol phosphate flippase (liver)
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000

metaR GGH 10FTHF7GLUl
product: MODEL1310110050#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), lysosomal
kinetic law: MODEL1310110050#
reversible: false
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
is described by: ECO:0000000

metaR r1683
name: Y+LAT2 Utilized transport
reactant: MODEL1310110050#
reversible: false
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ACTLMO
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1571.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:stoichiometry described in Thornalley PJ. Gen Pharmacol. 1996 Jun;27(4):565-73. PMID: 8853285 NCD
product: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
is described by: ECO:0000269
name: acetol monooxygenase
type: Reaction

metaR 4NPHSULT
is: SBO:0000176
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
type: Reaction
modifier: MODEL1310110050#
name: 4-Nitrophenol Sulfotransferase
reactant: MODEL1310110050#
fast: false
reversible: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1

http://identifiers.org/biomodels.db/MODEL1310110050#_b48cfc6d_2330_4fc2_8ee1_b33dae0ac30e
type: Species
has only substance units: false
name: SLC25A11
is encoded by: hsa:8402
initial concentration: NaN
boundary condition: true
is: F5GY65
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_7ce3cf6f_84f7_4d41_becf_0019a7f2739f
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: _AI345944_1_m
is encoded by: hsa:AI345944
initial concentration: NaN
has only substance units: false
type: Species

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM glx x
initial concentration: 1.0
initial amount: NaN
name: glyoxylate
type: Species
is: CHEBI:36655
is: HMDB00119
boundary condition: false
constant: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_8587c307_eec0_4912_ad5a_101a7497b272
initial concentration: NaN
constant: false
is: A8K003
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:5372
name: PMM1
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_c2056f32_4e83_4183_a67e_4caa7ed9232a
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6487
name: ST3GAL3
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaM rbt e
is: HMDB00508
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: D-ribitol
is: CHEBI:15963
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380

metaR r1682
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#

metaM Asn X Ser Thr r
is: C01342
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:28938
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
constant: false
name: protein-linked asparagine residue (N-glycosylation site)
initial amount: NaN
is: HMDB00051
is: SBO:0000247

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaM ocdcea c
is: C00712
initial concentration: 1.0
name: octadecenoate (n-C18:1)
is: CHEBI:0
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00207

http://identifiers.org/biomodels.db/MODEL1310110050#_b520742d_4e13_4e12_9cf4_9558041b7ee1
is: O43708
has only substance units: false
name: GSTZ1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:2954
constant: false
type: Species
is: SBO:0000252

metaR r1260
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction

metaM ptdcacrn m
constant: false
name: pendtadenoyl carnitine
is: HMDB01721
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15811
is: SBO:0000247
type: Species

metaR APOC LYS BTNPm
type: Reaction
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
is: SBO:0000176
reversible: false
name: proteolysis of apoC-Lys-btn, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_9f560251_d98e_4c81_a963_ccebcb034a6a
is: SBO:0000252
name: SLC6A12
initial amount: NaN
constant: false
initial concentration: NaN
is: P48065
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6539

http://identifiers.org/biomodels.db/MODEL1310110050#_f4b93951_59c8_425a_9260_c2f8a9e61f9d
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:65263
constant: false
has only substance units: false
initial concentration: NaN
is: Q53H96
name: PYCRL
boundary condition: true
type: Species

metaR DCMPDA
fast: false
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
reactant: MODEL1310110050#
type: Reaction
reversible: true
modifier: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.12
is: SBO:0000176
name: dCMP deaminase
kinetic law: MODEL1310110050#

metaR r1685
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
reversible: false
product: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
name: Y+LAT2 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_52edc4de_21bc_4456_9fd4_bd13bc5d4ff1
name: COASY
is: Q13057
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:80347
is: SBO:0000252
type: Species
initial concentration: NaN

metaR FAOXC160
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
reversible: false
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_d9f34121_3a9a_4c82_a3b8_c5553343446f
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q5TDP6
name: LGSN
constant: false
initial amount: NaN
is encoded by: hsa:51557

metaM cmpacna g
boundary condition: false
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
is: CHEBI:57812
is: HMDB01176
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_e139e6a4_f80b_4ce5_a5f5_a11bd02a6a86
initial concentration: NaN
initial amount: NaN
name: _J03866_1_m
boundary condition: true
is encoded by: hsa:J03866
constant: false
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_6cd7418d_36f1_4173_b8f8_71fd8e5fe10d
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: O15254
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8310
name: ACOX3
type: Species

metaM CE2839 e
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
boundary condition: false
is: C01936
constant: false
type: Species
name: maltodecaose
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_de6a70f1_bf35_4164_b13e_696c9c2c0a55
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2618
is: Q59HH3
name: GART
has only substance units: false
constant: false

metaR HISSNAT5tc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1684
reactant: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#
fast: false

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaM pac c
is: HMDB00209
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: SBO:0000247
has only substance units: false
is: CHEBI:18401
name: phenylacetate
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR DOLPGT1 Ler
fast: false
type: Reaction
product: MODEL1310110050#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.267
modifier: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176

metaM rbt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:15963
is: HMDB00508
name: D-ribitol

http://identifiers.org/biomodels.db/MODEL1310110050#_06bf1eb9_1eb6_4e30_871b_6666518cd7eb
initial amount: NaN
name: PHGDH
boundary condition: true
type: Species
is: O43175
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:26227
initial concentration: NaN

metaM ocdcea e
type: Species
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
has only substance units: false
boundary condition: false
is: CHEBI:0
initial amount: NaN
name: octadecenoate (n-C18:1)
is: C00712
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_818b37ee_ccbc_43c4_a10a_7b69b1597f54
initial amount: NaN
is encoded by: hsa:23475
is: SBO:0000252
is: Q15274
boundary condition: true
name: QPRT
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaR r2028
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110050#
reversible: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#

metaM pep m
name: Phosphoenolpyruvate
is: CHEBI:18021
is: C00074
initial concentration: 1.0
type: Species
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
has only substance units: false
constant: false
boundary condition: false
is: HMDB00263
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_84c486c4_cadf_4c3d_ba34_f421398c8484
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: O75912
is: SBO:0000252
name: DGKI
has only substance units: false
is encoded by: hsa:9162
type: Species

metaM nm2masn g
initial amount: NaN
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
type: Species
is: C05884
initial concentration: 1.0

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_7b9f00cb_235e_4495_9558_708df4d89935
constant: false
is encoded by: hsa:AA614647
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: _AA614647_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_ec8ae1ef_ce65_4ec9_b905_8222ae160102
is: Q96CD2
is encoded by: hsa:60490
initial amount: NaN
type: Species
name: PPCDC
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR NDP7er
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110050#_32b1e5ca_3ffd_43ef_87d6_7224f5a6d9bb
boundary condition: true
is encoded by: hsa:2590
name: GALNT2
initial amount: NaN
constant: false
is: Q10471
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR r1687
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110050#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

metaM CE5126 x
initial concentration: 1.0
is: HMDB00127
name: (2R)-pristanoyl-CoA
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
is: CHEBI:15748
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_0986e06d_32c7_488b_810e_addd72328515
is encoded by: hsa:5320
type: Species
initial concentration: NaN
has only substance units: false
name: PLA2G2A
initial amount: NaN
boundary condition: true
is: P14555
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5bb3839a_51a6_4867_9b2e_9a0bc5f33219
initial concentration: NaN
is: Q86SR1
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:55568
initial amount: NaN
name: GALNT10

metaM 7dhf e
is: SBO:0000247
initial amount: NaN
name: heptaglutamyl folate (DHF)
is: HMDB06559
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
boundary condition: false

metaR RE2625M
is: SBO:0000176
kinetic law: MODEL1310110050#
name: RE2625
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
reactant: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
product: MODEL1310110050#
fast: false

metaM cys L c
initial amount: NaN
constant: false
name: L-cysteine
is: HMDB00574
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:17561
initial concentration: 1.0

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR r1686
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185

metaR H2MTer L
fast: false
reversible: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110050#
name: H2 mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110050#
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_891b42b9_6413_4230_90a5_366e65e39d11
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7360
constant: false
is: Q16851
type: Species
name: UGP2
boundary condition: true

metaM xol7ah2al c
constant: false
initial amount: NaN
is: CHEBI:27428
type: Species
has only substance units: false
is: HMDB06894
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0

metaR NACHEX27ly
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110050#

metaR GLYGLYPEPT1tc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycyl-glycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR L LACt4r
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
fast: false
kinetic law: MODEL1310110050#
reversible: true
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
name: L-lactate reversible transport via sodium symport
is: SBO:0000185

metaR ACCOALm
is version of: http://identifiers.org/ec-code/6.2.1.1
name: acetate-CoA ligase (AMP-forming)
product: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_aca65d59_7b42_4dac_9407_384815d4db9c
boundary condition: true
is encoded by: hsa:89874
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: SLC25A21
constant: false
is: G3V4L5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_7bd9d1f9_5fa3_4650_bc85_e9453232a71d
initial amount: NaN
type: Species
is encoded by: hsa:5153
name: PDE1B
constant: false
is: Q7Z364
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_6f5ee2a0_dccf_4da2_998c_a9e69b393f6f
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3156
type: Species
name: HMGCR
constant: false
boundary condition: true
is: P04035
has only substance units: false
is: SBO:0000252

metaR GGH 10FTHF7GLUe
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
fast: false
modifier: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

http://identifiers.org/biomodels.db/MODEL1310110050#_3031b44c_74d1_4a08_80ab_4c856397dbf8
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: P43353
is encoded by: hsa:221
type: Species
boundary condition: true
name: ALDH3B1
initial concentration: NaN

metaM cmpacna c
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
is: SBO:0000247
is: HMDB01176
has only substance units: false
constant: false
type: Species

metaM akg e
constant: false
is: HMDB00208
has only substance units: false
is: CHEBI:16810
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: 2-oxoglutarate(2-)

metaM 3ohdcoa m
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB06402
is: SBO:0000247
is: CHEBI:57349
type: Species
initial amount: NaN
has only substance units: false
name: 3-oxopalmitoyl-CoA(4-)
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259

http://identifiers.org/biomodels.db/MODEL1310110050#_35f91c6e_c114_4263_8095_6386b33e267d
name: RBAK
is: Q9NYW8
is encoded by: hsa:57786
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR r1364
product: MODEL1310110050#
fast: false
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110050#
name: Vesicular transport

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaR LINKDEG1ly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_d0223064_f9a4_4988_8a0c_6598ebeb060c
is: P42765
initial concentration: NaN
has only substance units: false
constant: false
name: ACAA2
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10449

metaM ptdcacrn c
is: HMDB01721
initial amount: NaN
type: Species
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
boundary condition: false
is: CHEBI:15811
name: pendtadenoyl carnitine
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaM mi1345p c
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01059
initial amount: NaN
constant: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: CHEBI:57895
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_134d0bb2_cd97_4fcc_9fd7_c7e9a52dc431
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: PIP5K1C
is encoded by: hsa:23396
is: O60331

http://identifiers.org/biomodels.db/MODEL1310110050#_fb8f3738_9f93_4527_8da0_2d1888b31b42
type: Species
is encoded by: hsa:6818
name: SULT1A3
is: P50224
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR GLCAASE6ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
fast: false
name: beta-glucuronidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: false
type: Reaction
is: SBO:0000176

metaR PTDCACRNt
is described by: ECO:0000000
reactant: MODEL1310110050#
name: pentadecanoate transport into the mitochondria
is: SBO:0000185
reversible: false
modifier: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
type: Reaction

metaR GLNS
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
name: glutamine synthetase
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/4.1.1.15
fast: false
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_9dc6b6b7_fda3_4110_acd8_2f53d3531fd6
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: TMEM91
is: C9JZ62
boundary condition: true
is encoded by: hsa:641649

metaM akg c
is: C00026
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: 2-Oxoglutarate
is: CHEBI:16810
constant: false
has only substance units: false

metaR CYTK8n
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (CMP,dATP),nuclear
reversible: true
is: SBO:0000176
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110050#

metaM accoa x
initial amount: NaN
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: CHEBI:57288
has only substance units: false
is: C00024
initial concentration: 1.0
is: SBO:0000247
name: Acetyl-CoA
type: Species
boundary condition: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR A MANASEly
is version of: http://identifiers.org/ec-code/3.2.1.24
kinetic law: MODEL1310110050#
is: SBO:0000176
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
modifier: MODEL1310110050#
name: alpha-mannosidase, lysosomal
type: Reaction
reversible: false
product: MODEL1310110050#

metaM gua c
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
name: Guanine
is: CHEBI:16235
constant: false
initial concentration: 1.0
is: HMDB00132
is: C00242

http://identifiers.org/biomodels.db/MODEL1310110050#_eff9b9a1_b4cb_4df8_b169_003e1fda700f
is: P30613
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: PKLR
type: Species
is encoded by: hsa:5313
has only substance units: false

metaR ADK3m
reversible: true
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
name: adentylate kinase (GTP)
reactant: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.10
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_86b9f509_a8a4_4d80_b36b_cd6ac9d07688
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:594
type: Species
name: BCKDHB
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P21953

metaR ILETAm
is: SBO:0000176
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110050#
name: isoleucine transaminase, mitochondrial
fast: false
is described by: ECO:0000269
reversible: true
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction

metaR RE2814M
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: RE2814
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
reversible: true

metaR COUMARINte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
fast: false
reversible: true
product: MODEL1310110050#
type: Reaction
name: xenobiotic transport
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110050#

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

metaR r0909
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Transport reaction
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_8012001b_c3fb_402b_91e3_92eadb8d3e68
constant: false
name: ADSSL1
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q8N142
is: SBO:0000252
type: Species
is encoded by: hsa:122622

http://identifiers.org/biomodels.db/MODEL1310110050#_e15dd55e_9bcb_40b5_94ca_46bb7a1f7ea1
is: SBO:0000252
constant: false
is: P32119
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:7001
name: PRDX2

metaM icit x
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:16087
constant: false
name: isocitrate(3-)
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial concentration: 1.0
has only substance units: false
is: HMDB00193

metaR Q10H2e
is: SBO:0000185
reversible: true
name: transport of ubiquinol into lymph
reactant: MODEL1310110050#
type: Reaction
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

metaR r1365
name: Vesicular transport
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaR ESTRADIOLt
fast: false
name: estradiol transport
is described by: ECO:0000000
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110050#
reversible: true
type: Reaction

metaR UMPK6n
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase (dCTP),nuclear
fast: false
reversible: true
modifier: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110050#

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM cys L e
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: HMDB00574
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: L-cysteine
type: Species
has only substance units: false
is: CHEBI:17561

metaM ksi pre13 g
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: HMDB06552
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 13
is: CHEBI:2504

http://identifiers.org/biomodels.db/MODEL1310110050#_c79b9c5d_c4f2_4d6c_9c80_0519c672e710
initial concentration: NaN
has only substance units: false
name: NAGA
is: SBO:0000252
is: P17050
boundary condition: true
is encoded by: hsa:4668
type: Species
initial amount: NaN
constant: false

metaM hs deg6 l
boundary condition: false
initial amount: NaN
type: Species
is: HMDB06254
has only substance units: false
constant: false
name: heparan sulfate, degradation product 6
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C67H98N4O83S9 CHARGE: -10

http://identifiers.org/biomodels.db/MODEL1310110050#_b175d8b9_d359_494b_80cc_b39371d51f19
is: E9PAK4
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:200010
name: SLC5A9
has only substance units: false

metaR r0908
name: Postulated transport reaction
reactant: MODEL1310110050#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_2a86f7fe_4bf6_4c4e_9976_95038d36c07b
initial concentration: NaN
is encoded by: hsa:4645
is: Q9H6Y6
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: MYO5B
type: Species
is: SBO:0000252

metaM estradiol r
initial concentration: 1.0
initial amount: NaN
constant: false
name: estradiol
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00151
is: CHEBI:16469
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951

metaR r2308
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false

metaM gua e
constant: false
initial concentration: 1.0
boundary condition: false
name: guanine
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
is: SBO:0000247
is: CHEBI:16235

metaR r1574
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000185

metaM s7p c
is: C05382
initial concentration: 1.0
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: HMDB01068
name: Sedoheptulose 7-phosphate
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:57483
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_a0d15097_46fa_4613_967d_5c608af2fa53
is encoded by: hsa:8876
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: O95497
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: VNN1

metaR RE2974C
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.149
name: RE2974
modifier: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_0a2f9960_58cb_48ea_a417_0b72a1bb832e
type: Species
has only substance units: false
name: PLA2G2D
is: Q9UNK4
is encoded by: hsa:26279
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR Asn X Ser Thrtr
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
type: Reaction
name: Asn-X-Ser/Thr transport (from ER to lysosome)
fast: false
reactant: MODEL1310110050#
reversible: true
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185

metaM cmpacna n
boundary condition: false
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
has only substance units: false
is: CHEBI:57812
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_a65fae9b_dc15_43ff_9b6c_b69d8dcb4e31
name: ATP5J2
is: Q6IBB3
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:9551
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r1573
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_e4bb2e75_9f4a_4341_bf32_6d960f47528b
boundary condition: true
name: NSF
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4905
has only substance units: false
is: P46459
initial amount: NaN
constant: false

metaM arachdcoa x
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57368
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
type: Species
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
is: HMDB06523
is: SBO:0000247

metaM Rtotal3coa c
initial amount: NaN
name: R total 3 Coenzyme A
has only substance units: false
is: HMDB01448
constant: false
is: CHEBI:16189
initial concentration: 1.0
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
type: Species
boundary condition: false
is: SBO:0000247

metaM pep c
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
constant: false
name: Phosphoenolpyruvate
is: CHEBI:18021
is: HMDB00263
is: C00074
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR CH25H
reversible: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.14.99.38
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
type: Reaction
fast: false
modifier: MODEL1310110050#
name: cholesterol 25-hydroxylase

metaM dctp n
is: CHEBI:16311
name: dCTP
is: SBO:0000247
type: Species
constant: false
is: C00458
initial concentration: 1.0
is: HMDB00998
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
boundary condition: false
initial amount: NaN

metaR C8CRNe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR FORMCOAtx
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
name: formyl coa transport
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_2255a0e3_6b0d_4783_bd99_092d65eab976
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P36021
is encoded by: hsa:6567
constant: false
boundary condition: true
type: Species
name: SLC16A2

metaR HS4ly
fast: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.10.1.1
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#

metaR NDP7ex
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110050#
name: nucleoside-diphosphatase (UDP), extracellular
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
reversible: false
kinetic law: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false

metaR r1576
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110050#
product: MODEL1310110050#

metaR NRPPHRSFt
product: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
fast: false
name: norepinephrine sulfate transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM 3mb2coa m
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
type: Species
initial amount: NaN
is: CHEBI:57344
boundary condition: false
is: SBO:0000247
name: 3-methylbut-2-enoyl-CoA(4-)
is: HMDB01493
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_871921f0_06ba_4086_ad25_c221b6cb8b09
constant: false
initial amount: NaN
name: UCK2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9BZX2
has only substance units: false
is encoded by: hsa:7371
type: Species

metaR G13MT L
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.132
is described by: ECO:0000000
is: SBO:0000176
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
product: MODEL1310110050#
reversible: false
modifier: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

metaM Asn X Ser Thr l
is: CHEBI:28938
notes: FORMULA: XH CHARGE: 0
is: HMDB00051
type: Species
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: C01342
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f2f5f63f_121d_4dc3_80bb_c570686ffbca
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: UEVLD
has only substance units: false
is encoded by: hsa:55293
is: Q8IX04
boundary condition: true
constant: false

metaR CMPSASn
is described by: ECO:0000304
modifier: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
fast: false
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
name: CMP sialic acid synthase, nuclear
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_93f22023_52c4_4d57_b0e7_33a80f87252d
is: Q15392
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:1718
name: DHCR24
type: Species
initial amount: NaN
has only substance units: false

metaR r2309
fast: false
product: MODEL1310110050#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_a74e43e6_4d9d_4eaa_aa68_4978bdb224c1
type: Species
initial concentration: NaN
is: Q9H999
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:79646
name: PANK3

http://identifiers.org/biomodels.db/MODEL1310110050#_e25c9d13_64f3_44b5_b232_4cd68e819282
boundary condition: true
is: SBO:0000252
has only substance units: false
name: GCK
is: P35557
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2645

metaR r1575
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 3sala m
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: C00606
is: CHEBI:61085
initial amount: NaN
name: 3-sulfino-L-alanine (1-)
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
boundary condition: false

metaR ITPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
name: ITP nuclear transport
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR CORE2GTg
reversible: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110050#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.102
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_6cb0e045_401b_4cb1_b1ef_7621074e89b0
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51703
initial amount: NaN
is: Q9ULC5
type: Species
initial concentration: NaN
name: ACSL5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_ae0986c9_8c48_4af9_93ad_fd10d1f00753
name: MLYCD
is encoded by: hsa:23417
is: O95822
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM atp x
initial concentration: 1.0
boundary condition: false
is: HMDB00538
is: CHEBI:57299
is: SBO:0000247
constant: false
has only substance units: false
is: C00002
initial amount: NaN
name: ATP(4-)
type: Species

metaR FAOXC12DCTc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_20edf96a_41b7_4d78_a4e6_48dfd85b9825
has only substance units: false
initial amount: NaN
name: DHFR
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1719
is: P00374
constant: false
type: Species
is: SBO:0000252

metaR HSD3A2r
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
reversible: true
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_54992e38_bcf1_4675_9a10_947cd654b3cd
constant: false
has only substance units: false
name: SLC4A5
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57835

metaR DM T antigen g
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR r1581
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#

metaM ksi pre7 g
is: HMDB06552
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: CHEBI:2504
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_c1149ca6_2d8e_4de4_89a5_23a0b8f4f71c
initial concentration: NaN
is: O14735
has only substance units: false
name: CDIPT
is: SBO:0000252
is encoded by: hsa:10423
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR PLA2 2
reversible: false
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
name: phospholipase A2
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: MODEL1310110050#

metaR RE0915E
reactant: MODEL1310110050#
product: MODEL1310110050#
name: RE0915
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_bd219de4_269d_4cbe_a77d_ea8e3ef69ef0
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: _H77542_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:H77542

http://identifiers.org/biomodels.db/MODEL1310110050#_79df4e67_1170_47d9_bacf_35763c036e34
has only substance units: false
constant: false
type: Species
is encoded by: hsa:26289
boundary condition: true
is: SBO:0000252
name: AK5
initial concentration: NaN
initial amount: NaN

metaM c5dc e
constant: false
name: glutaryl carnitine
initial amount: NaN
type: Species
notes: FORMULA: C12H21NO6 CHARGE: 0
is: HMDB13130
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM hdcea e
is: SBO:0000247
type: Species
constant: false
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0
boundary condition: false
is: HMDB03229
has only substance units: false
is: CHEBI:32372
initial amount: NaN

metaM xol7ah2al m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
is: CHEBI:27428
constant: false
type: Species
initial concentration: 1.0
is: HMDB06894

http://identifiers.org/biomodels.db/MODEL1310110050#_ece9f21b_d902_47c0_b22f_958f35347340
boundary condition: true
type: Species
name: COX7A2
constant: false
is encoded by: hsa:1347
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: H0UI06
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_cfa70929_5727_4fd8_be2a_5eeb27479038
is: Q16739
initial concentration: NaN
name: UGCG
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:7357

metaM CE2838 e
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
name: maltononaose
constant: false
boundary condition: false
initial amount: NaN
is: C01936
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_f4ca3411_dd9d_4b6d_8712_3faddad7b66c
is: SBO:0000252
is encoded by: hsa:1603
is: Q53G02
constant: false
has only substance units: false
name: DAD1
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaM f1a l
is: HMDB02917
constant: false
name: F1alpha
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:17151
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_51c89e40_6d5f_4e11_9053_02bcec3d36af
initial amount: NaN
boundary condition: true
constant: false
name: PDE8A
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5151
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_ada96790_10c7_4261_aa73_3880af6e0dc8
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3038
type: Species
is: SBO:0000252
name: HAS3
constant: false
is: Q96RV2

metaR THRGLNexR
type: Reaction
is described by: ECO:0000304
product: MODEL1310110050#
reversible: true
is: SBO:0000185
modifier: MODEL1310110050#
fast: false
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR NDPK7n
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
modifier: MODEL1310110050#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
reactant: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_68b23f00_c12c_4df7_984e_f4eac2cea928
is encoded by: hsa:50
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: ACO2
is: Q99798
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_7173b1dd_51c5_48f2_a75f_d997ba75db08
is encoded by: hsa:52
constant: false
name: ACP1
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q59EH3
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r1109
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is described by: ECO:0000000

metaR r0093
is described by: ECO:0000000
modifier: MODEL1310110050#
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
fast: false
type: Reaction
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: false

metaM ile L m
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: L-isoleucine
initial amount: NaN
is: CHEBI:17191
boundary condition: false
is: HMDB00172
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaM dcholcoa c
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB06292
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false

metaR r0911
is described by: ECO:0000000
name: Facilitated diffusion
reversible: true
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000185

metaR r1583
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110050#

metaR DGSNtm
kinetic law: MODEL1310110050#
name: deoyguanosine transport in mitochondria
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110050#
type: Reaction

metaR DEBRISOQUINEt
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6582.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
name: debrisoquine uniport
is: SBO:0000185
product: MODEL1310110050#

metaR RE2973C
kinetic law: MODEL1310110050#
name: RE2973
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: true
product: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false

metaM tre e
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
type: Species
has only substance units: false
is: HMDB00975
name: Trehalose
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16551
constant: false
is: C01083

metaM prostgf2 e
has only substance units: false
is: CHEBI:57404
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
type: Species
constant: false
initial amount: NaN
is: HMDB01139
is: SBO:0000247
name: prostaglandin F2alpha(1-)
initial concentration: 1.0

metaR ST3GAL23g
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
is described by: ECO:0000269
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176

metaM 3ohdcoa x
has only substance units: false
is: CHEBI:57349
name: 3-oxopalmitoyl-CoA(4-)
is: SBO:0000247
constant: false
is: HMDB06402
initial concentration: 1.0
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_4b6d3f67_c7ff_4b8f_a41b_7b41de2206ac
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O95340
name: PAPSS2
is encoded by: hsa:9060
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_b6bdb84e_83b2_4aea_ab61_033504d6fcaa
has only substance units: false
is encoded by: hsa:57134
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: MAN1C1
is: SBO:0000252
is: Q9NR34

metaR RE1534M
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
name: RE1534
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110050#

metaR SERDGLYexR
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000304
name: D-Serine/Glycine reversible exchange
reactant: MODEL1310110050#
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_4d50ee63_97cb_4c27_9167_98539097fd30
is: SBO:0000252
constant: false
name: HSD3B2
is: P26439
is encoded by: hsa:3284
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR PAN4PPe
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000176
product: MODEL1310110050#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
name: PAN4PPe
reversible: false
kinetic law: MODEL1310110050#

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR r1584
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
reversible: true
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction

metaM btamp c
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
name: Biotinyl-5'-AMP
is: HMDB04220
has only substance units: false
is: CHEBI:3110
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_9e76c792_84a0_46d0_947e_bc70fe4dbf4c
is: P04844
name: RPN2
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6185
constant: false
initial concentration: NaN

metaM glx c
name: glyoxylate
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: CHEBI:36655
is: SBO:0000247
constant: false
is: HMDB00119

metaR LTC4CP
reactant: MODEL1310110050#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
fast: false
name: Leukotriene C4 carboxypeptidase
type: Reaction

metaR TRPt
modifier: MODEL1310110050#
name: L-tryptophan transport
product: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110050#
fast: false
reversible: true

metaR r0716
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110050#
fast: false
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
is: SBO:0000176

metaR r0913
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
reversible: true
fast: false
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_448b05c0_a0f4_4345_a542_a97f0247a666
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6573
type: Species
is: Q9BTX8
has only substance units: false
name: SLC19A1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_1957f8fe_04fa_4d01_afdc_df269591337d
is: Q9ULC5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: ACSL5
is encoded by: hsa:51703
initial amount: NaN
has only substance units: false

metaM f1a g
has only substance units: false
is: CHEBI:17151
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: HMDB02917
initial concentration: 1.0
boundary condition: false
name: F1alpha
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_0f5eebfc_c6a5_4d95_b820_fc25d7d98420
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:55350
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: VNN3

metaM chol n
is: HMDB00097
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15354

http://identifiers.org/biomodels.db/MODEL1310110050#_0cd38b6e_e5e3_40cc_9c08_a521eab41d57
constant: false
is encoded by: hsa:3030
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: E9KL44
has only substance units: false
name: HADHA
boundary condition: true

metaR r0603
reversible: true
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
modifier: MODEL1310110050#
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12

metaR M1316Mg
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
fast: false
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110050#
reversible: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.114

metaR PI345P3P
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.3.67
is described by: ECO:0000000
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM thmpp c
is: SBO:0000247
is: C00068
is: HMDB01372
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: Thiamine diphosphate
has only substance units: false
is: CHEBI:45931
constant: false
type: Species

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: CHEBI:57404
constant: false
type: Species
initial amount: NaN
name: prostaglandin F2alpha(1-)
initial concentration: 1.0
is: HMDB01139
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR HAS2
product: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.212
fast: false
is: SBO:0000185
type: Reaction
reversible: false
name: hyaluronan synthase

metaR r0715
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.3.2.5
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_8d028ff9_a762_41a9_973c_6016cb5950fe
initial amount: NaN
name: HMOX2
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: P30519
constant: false
is encoded by: hsa:3163

http://identifiers.org/biomodels.db/MODEL1310110050#_579bcdeb_0f09_459e_8c81_df4f2fc08237
is: A7E2E0
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: PIK3CD
constant: false
is encoded by: hsa:5293
initial amount: NaN
is: SBO:0000252

metaM 3aib D e
is: HMDB02299
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
name: D-3-Amino-isobutanoate
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: C03265
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_89df0eae_75d8_42d5_961b_d98832db1c56
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: E5KS60
has only substance units: false
constant: false
type: Species
is encoded by: hsa:8803
name: SUCLA2

http://identifiers.org/biomodels.db/MODEL1310110050#_d76c0645_52ff_4899_b313_d445ae842a6d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P78382
is encoded by: hsa:10559
boundary condition: true
name: SLC35A1
constant: false
initial amount: NaN

metaR r0719
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (6697.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
modifier: MODEL1310110050#
is: SBO:0000176
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.153

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM ocdcea r
boundary condition: false
initial concentration: 1.0
is: CHEBI:0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00207
type: Species
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712

metaM malttr e
is: SBO:0000247
is: HMDB01262
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: maltotriose
initial concentration: 1.0
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: C01835
is: CHEBI:27931

metaM 3mop m
is: CHEBI:28654
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
has only substance units: false
is: HMDB00491
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN

metaM 3m4hpga c
is: HMDB04061
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: SBO:0000247
is: C05583
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7909
constant: false

metaM c5dc c
notes: FORMULA: C12H21NO6 CHARGE: 0
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
name: glutaryl carnitine
is: HMDB13130

metaR DOPASFt
reactant: MODEL1310110050#
name: Dopamine 3-0-sulfate transport (diffusion)
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
product: MODEL1310110050#

metaM man1p c
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:35374
constant: false
name: D-Mannose 1-phosphate
is: SBO:0000247
type: Species
is: HMDB06330
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636

metaR r0097
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
reactant: MODEL1310110050#
is: SBO:0000176
fast: false
product: MODEL1310110050#

metaM cs e deg6 l
is: HMDB00812
boundary condition: false
type: Species
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: CHEBI:16953
is: SBO:0000247
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
constant: false
has only substance units: false
initial concentration: 1.0

metaR C40CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM HC00319 c
name: Malonate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3421dbe5_681c_4c87_b8a7_6fb987a96f9c
name: DGKD
initial amount: NaN
is: Q16760
initial concentration: NaN
is encoded by: hsa:8527
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaR r0915
product: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_59d8d78d_59ed_4419_9fb4_7ced0d00a2da
has only substance units: false
is encoded by: hsa:11112
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: HIBADH
constant: false
is: P31937
initial amount: NaN

metaR r1580
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000000
fast: false

metaR r0917
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_46bd4ca6_66a0_4360_9276_de9bf10a1af1
constant: false
name: HK1
initial amount: NaN
is: A8K7J7
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3098

metaR r1259
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000000
name: EC:6.2.1.3
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_7a6e1e36_6041_4dc8_a4f6_f0379586fa1f
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:23530
name: NNT

http://identifiers.org/biomodels.db/MODEL1310110050#_17dc737f_8d26_49c4_8aeb_a35721fb52d4
is encoded by: hsa:8277
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: TKTL1
is: SBO:0000252
is: B7Z7I0
constant: false

metaR 2OXOADOXm
type: Reaction
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
reversible: false
product: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
is version of: http://identifiers.org/ec-code/2.3.1.61

metaR CITtam
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is described by: ECO:0000269
fast: false
name: citrate transport, mitochondrial
kinetic law: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#

metaR GLYt7 311 r
reactant: MODEL1310110050#
fast: false
reversible: true
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: glycine reversible transport via sodium and chloride symport (3:1:1)
product: MODEL1310110050#
is: SBO:0000185
modifier: MODEL1310110050#
is described by: ECO:0000006
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_2f99db7d_f71d_4b71_8ca2_74c8f2c31513
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7298
type: Species
name: TYMS
constant: false
initial amount: NaN
is: P04818
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_73e238a8_a275_4f9b_8360_e7f7b8c5700a
initial amount: NaN
is encoded by: hsa:AI620219
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: _AI620219_1_m
initial concentration: NaN
boundary condition: true

metaM 3aib D c
type: Species
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: HMDB02299
has only substance units: false
constant: false
is: SBO:0000247
name: D-3-Amino-isobutanoate
boundary condition: false
initial amount: NaN
is: C03265

metaR r0604
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
product: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reversible: false

metaR r0717
product: MODEL1310110050#
type: Reaction
reversible: false
kinetic law: MODEL1310110050#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000

metaM chol m
initial amount: NaN
has only substance units: false
is: CHEBI:15354
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_db21d591_15b1_4352_b4b2_2de56572c2b5
is: P04075
initial concentration: NaN
is encoded by: hsa:226
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: ALDOA
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_89f8db81_61e7_4af1_8554_2c352c1b790d
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2591
name: GALNT3
is: Q14435
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_109222d2_94d2_4dfa_8f54_ecd8000333e7
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: Q16719
name: KYNU
boundary condition: true
is encoded by: hsa:8942
type: Species
initial concentration: NaN

metaM phytcoa c
is: CHEBI:57391
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01359
has only substance units: false
initial amount: NaN
name: phytanoyl-CoA(4-)
is: SBO:0000247
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1

metaR r1464
name: Active transport
is described by: ECO:0000000
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110050#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110050#
reversible: true

metaM dhap c
is: HMDB01473
initial amount: NaN
is: CHEBI:57642
boundary condition: false
is: C00111
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: Dihydroxyacetone phosphate
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM xoltetrol c
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: HMDB01231
is: CHEBI:17278
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR DGSNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110050#
name: deoyguanosine transport via diffusion

metaR RE2626C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
type: Reaction
is: SBO:0000176
fast: false
name: RE2626
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaM 3sala c
type: Species
is: SBO:0000247
is: C00606
initial amount: NaN
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: CHEBI:61085
constant: false
name: 3-Sulfino-L-alanine
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3f205edd_185e_4fa0_a582_9ea0efadaca7
name: _AI091231_1_c
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI091231
initial concentration: NaN

metaM 3mop c
initial concentration: 1.0
has only substance units: false
is: CHEBI:28654
constant: false
is: HMDB00491
initial amount: NaN
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
boundary condition: false
type: Species

metaM 3ivcrn c
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB06870
is: SBO:0000247
boundary condition: false
name: 3-hydroxy-isovaleryl carnitine
initial amount: NaN
notes: FORMULA: C12H23NO5 CHARGE: 0

metaR INSTt4
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
name: inositol transport via sodium symport
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269
modifier: MODEL1310110050#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#

metaM sebacid x
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00792
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H16O4 CHARGE: -2
boundary condition: false
name: sebacicacid
is: C08277
type: Species

metaM em2emgacpail prot hs r
constant: false
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
has only substance units: false
initial concentration: 1.0
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
type: Species
is: CHEBI:16870
is: HMDB00086
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_9f3d5dd0_4f8b_4b44_9da5_09dd8a2e7c99
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q86XP1
is: SBO:0000252
type: Species
name: DGKH
is encoded by: hsa:160851
initial concentration: NaN

metaM co c
is: HMDB01361
has only substance units: false
name: carbon monoxide
is: CHEBI:17245
initial concentration: 1.0
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false

metaR LNLCCRNt
is described by: ECO:0000269
product: MODEL1310110050#
reversible: false
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110050#
fast: false
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110050#
is: SBO:0000185

metaR CSNATr
is: SBO:0000176
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
name: carnitine O-acetyltransferase
fast: false

metaR DHPM2
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
name: dihydropyrimidinase (dihydrothymine)
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_c6efbf12_ffdd_4748_a487_13b186be2834
name: AUH
is: Q13825
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:549
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_679f65cb_637d_4244_9255_820f6ed0d0e6
constant: false
initial amount: NaN
name: FOLR1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:2348

metaR ENGASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal

metaR r0714
is described by: ECO:0000000
product: MODEL1310110050#
fast: false
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reversible: false
reactant: MODEL1310110050#
is: SBO:0000176

metaM dhap e
is: CHEBI:57642
name: glycerone phosphate(2-)
has only substance units: false
is: HMDB01473
constant: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r1466
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: true
name: EC:2.3.1.86
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_af1e78e1_3aac_4486_a714_17af20c96a6c
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:NOS2A
name: _NOS2A_1_e

metaM C02528 r
name: chenodeoxycholate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN
is: HMDB00518
boundary condition: false
type: Species
constant: false

metaM 3ivcrn e
is: SBO:0000247
has only substance units: false
constant: false
name: 3-hydroxy-isovaleryl carnitine
boundary condition: false
is: HMDB13325
notes: FORMULA: C12H23NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species

metaM glx m
is: HMDB00119
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: CHEBI:36655
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: glyoxylate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_d850f711_a1a3_4418_b070_ad169b10950b
initial amount: NaN
type: Species
name: SLC29A2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3177
boundary condition: true
constant: false
initial concentration: NaN
is: Q14542

metaM ca2 e
type: Species
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
has only substance units: false
boundary condition: false
constant: false
is: HMDB00464
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_5b47689a_2f00_465e_93e0_bb2ace7a4c02
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5052
is: Q06830
initial amount: NaN
constant: false
name: PRDX1
boundary condition: true
has only substance units: false
type: Species

metaR ADPCOAPTE
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_0e2be02f_9c9f_4a3f_a08e_59c2d494caca
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P23921
type: Species
name: RRM1
constant: false
is encoded by: hsa:6240
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_4e9b163b_b5cb_4d49_a2ea_bf98ae17e4df
is encoded by: hsa:1375
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: E9PCP2
name: CPT1B
has only substance units: false

metaR r1467
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110050#

metaR RE0926E
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110050#
fast: false
name: RE0926

metaR r2310
reversible: true
is: SBO:0000185
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR MECOAS1m
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110050#
reversible: true
is described by: ECO:0000304
product: MODEL1310110050#
modifier: MODEL1310110050#
name: mesaconate--CoA ligase (GDP-forming)

http://identifiers.org/biomodels.db/MODEL1310110050#_46f324d9_3d11_49a5_a0f5_2a2c6f8c8325
is encoded by: hsa:518
constant: false
has part: P24539
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:515
has part: O75947
is: SBO:0000297
initial concentration: NaN
has part: P18859
has only substance units: false
type: Species
is encoded by: hsa:522
is encoded by: hsa:10476
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_cf23b7b9_5cf7_4b7a_8637_6a9585af4c3b
initial concentration: NaN
is encoded by: hsa:29920
type: Species
initial amount: NaN
is: Q96C36
is: SBO:0000252
name: PYCR2
constant: false
boundary condition: true
has only substance units: false

metaR 3SPYRSPm
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_2de22576_ae2c_4cc7_b6c0_5590ca949665
is encoded by: hsa:54677
boundary condition: true
constant: false
initial concentration: NaN
is: E7EQF2
name: CROT
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reversible: true
fast: false
name: RE3272
reactant: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction

metaM gm2 hs g
has only substance units: false
notes: FORMULA: C49H85N3O25FULLRCO CHARGE: -1
name: N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-beta-D-glucosyl-(1<->1)-ceramide anion
is: CHEBI:58857
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR CSNATp
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
reactant: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000304
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
name: carnitine O-acetyltransferase, reverse direction, peroxisomal

metaM CE2705 n
type: Species
initial concentration: 1.0
name: quinonoid dihydrobiopterin
boundary condition: false
is: HMDB02281
is: CHEBI:15374
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
constant: false

metaR C12DCACOT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaM hdcea r
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
is: SBO:0000247
name: palmitoleate
boundary condition: false
is: CHEBI:32372
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_c00aee6d_005b_4015_bad8_647567361d6a
is: SBO:0000252
is encoded by: hsa:3141
is: P50747
constant: false
boundary condition: true
has only substance units: false
type: Species
name: HLCS
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_0c59f62f_c513_4a16_b2c4_ccc117b8132e
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8525
boundary condition: true
name: DGKZ
is: G3V0F6
constant: false

metaR GLCter
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
product: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
name: glucose transport, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
fast: false

metaM ca2 c
initial amount: NaN
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
is: SBO:0000247
constant: false
name: calcium(2+)
has only substance units: false
initial concentration: 1.0
is: HMDB00464
boundary condition: false
type: Species

metaR ST8SIA52g
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_bc719e55_af8f_4841_a727_575820f9ad76
has only substance units: false
initial amount: NaN
is: E7ETH5
constant: false
name: SLC13A2
is encoded by: hsa:9058
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_db49599c_d902_4213_9b13_28b15ed3b293
is: Q8IW54
has only substance units: false
is encoded by: hsa:5138
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: PDE2A
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_2378d806_0745_447f_b829_ad0a1e8112be
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is: Q308M7
is encoded by: hsa:5169
initial concentration: NaN
type: Species
boundary condition: true
name: ENPP3

http://identifiers.org/biomodels.db/MODEL1310110050#_5b316af2_84d1_4c66_a252_39519ffd7223
initial amount: NaN
initial concentration: NaN
name: _AF116616_1_m
constant: false
is encoded by: hsa:AF116616
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR CSPG Ctly
product: MODEL1310110050#
name: chondroitin sulfate C transport, extracellular to lysosome
type: Reaction
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000

metaR PHEATB0tc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Phenylalanine into the intestinal cells by ATB0 transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_1bd57673_0d83_484f_bf7f_9f34da8a1384
constant: false
has only substance units: false
is encoded by: hsa:9245
name: GCNT3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: O95395

http://identifiers.org/biomodels.db/MODEL1310110050#_1b170ddd_4c46_4196_b016_30da87c2d64a
is: O95427
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: PIGN
is encoded by: hsa:23556

http://identifiers.org/biomodels.db/MODEL1310110050#_87eb0f51_2c51_46a0_8683_85a32188c33f
type: Species
is: P08195
is: SBO:0000252
is encoded by: hsa:6520
boundary condition: true
initial amount: NaN
constant: false
name: SLC3A2
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_129304e3_3b4f_4720_a0ee_2fa319ee0d30
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23428
has only substance units: false
is: Q86U05
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: SLC7A8

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110050#
is: SBO:0000185
name: adenosine 3',5'-bisphosphate Golgi transport

metaM 5aizc c
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: Species
initial concentration: 1.0
is: HMDB06273
has only substance units: false
is: CHEBI:58564
is: C04751
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

metaR SPC HSt
name: sphingosylphosphorylcholine transport (diffusion)
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaM 4nphsf c
name: 4-Nitrophenyl sulfate
is: CHEBI:35422
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB06492
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial amount: NaN
type: Species
constant: false

metaM g3pc c
boundary condition: false
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
has only substance units: false
is: HMDB00086
constant: false
is: CHEBI:16870
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: sn-Glycero-3-phosphocholine

metaR NRPPHRt4 2 r
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000269
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_42f066ab_9e50_4854_920a_30bab01ddb54
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6120
initial concentration: NaN
is: SBO:0000252
is: Q96AT9
boundary condition: true
initial amount: NaN
name: RPE

http://identifiers.org/biomodels.db/MODEL1310110050#_6e99b5e2_5e1e_43a2_8070_9ecec3545fdb
boundary condition: true
initial concentration: NaN
type: Species
is: B4DYG5
initial amount: NaN
has only substance units: false
is encoded by: hsa:5297
name: PI4KA
constant: false
is: SBO:0000252

metaR PRPPS
product: MODEL1310110050#
is: SBO:0000176
name: phosphoribosylpyrophosphate synthetase
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.6.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_da2babdd_eb7c_4265_aa3d_cf5eb595532d
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q99808
name: SLC29A1
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2030

metaR CSNATm
reversible: true
name: carnitine O-aceyltransferase, mitochondrial
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
is described by: ECO:0000269

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_3ee6eb42_5e06_4279_9d9f_4d821315fb30
has only substance units: false
is encoded by: hsa:5277
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: PIGA
boundary condition: true
initial amount: NaN

metaR DHPM1
is: SBO:0000176
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
fast: false
name: dihydropyrimidinase (5,6-dihydrouracil)
modifier: MODEL1310110050#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.5.2.2

metaR PRAGSr
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: phosphoribosylglycinamide synthase
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_4e095c82_9343_4097_8076_45537a5fdc09
type: Species
is encoded by: hsa:11332
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: O00154
has only substance units: false
name: ACOT7

metaR GLNtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reversible: false
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: L-glutamine transport via electroneutral transporter

metaR UPP3S
modifier: MODEL1310110050#
reversible: false
name: uroporphyrinogen-III synthase
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.1.75
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:

metaR r1106
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Postulated transport reaction

metaM chol e
is: SBO:0000247
name: Choline
initial amount: NaN
is: HMDB00097
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
initial concentration: 1.0
has only substance units: false
is: C00114
type: Species
is: CHEBI:15354

metaM HC00319 m
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
name: Malonate
initial concentration: 1.0
is: CHEBI:30794

metaM co e
constant: false
is: SBO:0000247
is: HMDB01361
is: CHEBI:17245
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: carbon monoxide
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_19c95865_6cfd_4e75_8a31_55bfc567b08d
is: O43772
initial amount: NaN
constant: false
is encoded by: hsa:788
has only substance units: false
initial concentration: NaN
name: SLC25A20
is: SBO:0000252
boundary condition: true
type: Species

metaM 4nphsf e
is: CHEBI:35422
is: SBO:0000247
name: 4-Nitrophenyl sulfate
initial concentration: 1.0
boundary condition: false
is: HMDB06492
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)

http://identifiers.org/biomodels.db/MODEL1310110050#_4eaefeda_532b_4c18_82df_ee1a8db89c7f
name: CTPS1
is encoded by: hsa:1503
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P17812
type: Species
constant: false

metaM tetdece1crn c
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H39NO4 CHARGE: 0
is: HMDB02014
boundary condition: false
type: Species
is: SBO:0000247
name: tetradecenoyl carnitine

metaM dhap m
name: Dihydroxyacetone phosphate
initial concentration: 1.0
is: SBO:0000247
is: C00111
has only substance units: false
constant: false
boundary condition: false
is: HMDB01473
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3411

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
has only substance units: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
is: HMDB01166
initial amount: NaN
is: CHEBI:57316
constant: false
type: Species
is: SBO:0000247

metaM HC02217 e
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2
has only substance units: false
boundary condition: false

metaR ACGAM6PSi
reactant: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.4
product: MODEL1310110050#
name: N-acetylglucosamine-6-phosphate synthase
is described by: ECO:0000304
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r0193
type: Reaction
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true

metaR XYLtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
name: Xylose efflux from lysosome
reversible: false
kinetic law: MODEL1310110050#
is: SBO:0000185
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#

metaM 1pipdn2c x
is: HMDB01084
initial amount: NaN
boundary condition: false
constant: false
name: 1-piperideine-2-carboxylate
has only substance units: false
is: CHEBI:16187
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM 4mlacac c
initial concentration: 1.0
constant: false
is: HMDB02052
is: CHEBI:17105
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: SBO:0000247
name: 4-maleylacetoacetate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_f63d637e_7447_4d04_abc2_9a43c3074830
boundary condition: true
initial amount: NaN
is encoded by: hsa:1384
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: CRAT
is: SBO:0000252

metaR r2318
fast: false
reversible: true
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM pyr x
is: CHEBI:15361
constant: false
initial amount: NaN
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: C00022
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_794ca85e_e79a_4928_ad54_f253c8f5012e
name: ACOX1
has only substance units: false
boundary condition: true
is: B4DK61
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:51
initial amount: NaN

metaM gal c
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: C00124
is: HMDB00143
is: CHEBI:0
is: SBO:0000247
name: D-Galactose
initial concentration: 1.0

metaR EX 3ddcrn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR ACGAMPM
is version of: http://identifiers.org/ec-code/5.4.2.3
product: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
kinetic law: MODEL1310110050#
name: phosphoacetylglucosamine mutase
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110050#

metaM m8mpdol L r
boundary condition: false
initial concentration: 1.0
type: Species
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:59093

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_2e3fc689_8144_4c9a_b4e1_f1d68713c62b
has part: Q9UHI5
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000297
is encoded by: hsa:23428
name: SLC7A8:SLC3A2

metaM HC02213 c
is: CHEBI:28031
is: SBO:0000247
name: prostaglandin-e3
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_72026fd9_1d7b_4403_959d_0d9390460b8c
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:3633
is: P32019
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: INPP5B

metaM 34dhpac c
is: SBO:0000247
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
constant: false
has only substance units: false
name: 3,4-Dihydroxyphenylacetaldehyde
is: CHEBI:27978
is: HMDB03791
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_1f3e7b9b_00e3_47b3_a207_eb11b50a749b
name: ATP5L
is encoded by: hsa:10632
constant: false
type: Species
initial amount: NaN
is: O75964
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR ETFQO
reversible: false
is: SBO:0000176
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.5.1
type: Reaction
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_455b7029_86bf_4180_816f_2e534d9386ef
constant: false
boundary condition: true
has only substance units: false
type: Species
name: PDE7A
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5150
initial concentration: NaN

metaM lnlncg e
type: Species
is: SBO:0000247
is: CHEBI:32391
boundary condition: false
name: gamma-linolenate
is: HMDB03073
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
has only substance units: false
constant: false

metaR r2317
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true

metaM tym c
is: HMDB00306
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: tyraminium
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: CHEBI:327995

http://identifiers.org/biomodels.db/MODEL1310110050#_e13f5284_da01_403d_b49c_c541b2de24e8
initial concentration: NaN
name: CYP2A6
initial amount: NaN
has only substance units: false
is encoded by: hsa:1548
is: P11509
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_839d5e7b_f635_4020_82d7_48fe4d3088ea
is encoded by: hsa:AI620219
initial amount: NaN
constant: false
has only substance units: false
name: _AI620219_1_c
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_23cbb6d3_71cb_4106_8a83_b7a2ce8c8e3f
is encoded by: hsa:518
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000297
has part: P48201
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
type: Species

metaM tetdece1crn e
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C21H39NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: tetradecenoyl carnitine
is: HMDB02014

metaR 34HPPOR
modifier: MODEL1310110050#
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110050#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.13.11.27
fast: false
kinetic law: MODEL1310110050#
type: Reaction

metaR G14T8g
is: SBO:0000176
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247
has only substance units: false
name: prostaglandin-g2
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:27647
type: Species
initial concentration: 1.0

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR SERtN1
fast: false
name: Serine transport (Na, H coupled)
reactant: MODEL1310110050#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_3fa69345_6f12_4438_83ce_ec5321abb14f
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: Q9NTN3
constant: false
is encoded by: hsa:23169
is: SBO:0000252
initial concentration: NaN
name: SLC35D1

metaM maltpt e
is: HMDB01296
boundary condition: false
is: SBO:0000247
name: maltopentaose
is: C02052
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141
has only substance units: false

metaR TMDPK
is: SBO:0000176
fast: false
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000269
type: Reaction
reversible: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.6.2

metaM HC02213 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
constant: false
boundary condition: false
type: Species
name: prostaglandin-e3
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28031

http://identifiers.org/biomodels.db/MODEL1310110050#_cf5d20dc_3bfc_4a86_a515_26b7f6abf79d
has only substance units: false
type: Species
is: SBO:0000252
name: _AW277253_1_c
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AW277253

metaM 2mop c
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57700
is: HMDB01172
type: Species
name: 2-methyl-3-oxopropanoate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_c87fd40c_d182_49fb_92a2_ba26705d45a0
constant: false
name: ACAD8
is: Q6ZWP6
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:27034
is: SBO:0000252
initial amount: NaN

metaM cs a deg5 l
is: CHEBI:15936
constant: false
initial concentration: 1.0
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
notes: FORMULA: C23H36O24S CHARGE: -2
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

metaR r1671
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_2ce88a04_c3c4_4b46_8441_df1952adfe80
constant: false
type: Species
is: SBO:0000252
is: A6NN98
initial amount: NaN
name: MTMR2
has only substance units: false
is encoded by: hsa:8898
initial concentration: NaN
boundary condition: true

metaM crm hs c
initial amount: NaN
has only substance units: false
name: N-acylsphingosine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
type: Species
constant: false
is: CHEBI:52639

http://identifiers.org/biomodels.db/MODEL1310110050#_5553be5f_2542_4fff_99e1_47d46173d684
initial concentration: NaN
is: SBO:0000252
name: _AI935189_1_m
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:AI935189
boundary condition: true

metaR DOLK L
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.7.1.108 Confidence Level: 0 AUTHORS: NOTES:
name: Dolichol kinase, human (liver)
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false

metaM dhcholestancoa x
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: HMDB02159
type: Species
is: CHEBI:15494
constant: false

metaR P45027A11m
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110050#
is: SBO:0000176
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110050#_9a663748_c587_4748_9cb5_a400a92737bb
is encoded by: hsa:51102
constant: false
has only substance units: false
is: Q9BV79
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: MECR

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_a6a944c8_e17a_458d_8102_9dbb573facac
is encoded by: hsa:622
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: BDH1

metaR FAOXC16DCr
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_0d6e3944_d627_4329_9153_848f395ab75d
type: Species
is: SBO:0000252
constant: false
name: ACOX3
is encoded by: hsa:8310
initial concentration: NaN
is: O15254
boundary condition: true
has only substance units: false
initial amount: NaN

metaM trdox c
constant: false
type: Species
is: C00343
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: SBO:0000247
is: CHEBI:18191
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Oxidized thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110050#_8e70a0d7_5516_4f27_bb06_a15a1556d928
is encoded by: hsa:6646
initial concentration: NaN
type: Species
is: B4DU95
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SOAT1
has only substance units: false
constant: false

metaR r2315
fast: false
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_5b347fa5_d617_4829_a794_ac2b950090c7
constant: false
is encoded by: hsa:6005
is: Q96E98
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: RHAG
initial concentration: NaN
initial amount: NaN

metaR r0196
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#

metaR r1670
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ADCim
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
fast: false

metaM phytcoa x
constant: false
is: SBO:0000247
name: phytanoyl-CoA(4-)
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: HMDB01359
is: CHEBI:57391
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_de3b3ca7_7b0d_4293_95bd_884306a06cf4
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: Q5JZF5
name: ALAS2
is encoded by: hsa:212

http://identifiers.org/biomodels.db/MODEL1310110050#_15c06261_1394_47fb_b8c2_d2d4226619c9
type: Species
initial concentration: NaN
name: ALDH9A1
is: SBO:0000252
is: P49189
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:223

metaM arachdcoa c
initial amount: NaN
name: arachidonoyl-CoA(4-)
is: HMDB06523
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:57368
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_45e70b1e_cc41_4ff2_9d53_97ba53d7054d
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NIT2
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: Q9NQR4
is encoded by: hsa:56954

metaR r2314
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#

metaR r2037
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR BDHm
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.30
reversible: true
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
reactant: MODEL1310110050#
fast: false

metaM acmana c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: CHEBI:17122
boundary condition: false
name: N-acetyl-D-mannosamine
has only substance units: false
constant: false
is: HMDB01129
initial concentration: 1.0
type: Species

metaM dhcholestancoa r
is: SBO:0000247
constant: false
is: HMDB02159
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
type: Species
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644

metaM acetone e
is: HMDB01659
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
name: acetone
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15347

http://identifiers.org/biomodels.db/MODEL1310110050#_76c07d82_1137_4614_84a6_f29ae0c420bf
name: GPX4
is: P36969
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:2879
has only substance units: false

metaR HEX1
product: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
name: hexokinase (D-glucose:ATP)
reactant: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
modifier: MODEL1310110050#

metaR r2313
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110050#

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM CE2424 m
is: CHEBI:28387
constant: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: HMDB11123
has only substance units: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_e22383f7_fb46_4e35_b6b1_49e5ad0f440d
constant: false
is encoded by: hsa:5092
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PCBD1
boundary condition: true

metaR HEX4
fast: false
name: hexokinase (D-mannose:ATP)
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.1.2
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110050#

metaR r0191
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000
modifier: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.24
fast: false
reversible: false
type: Reaction

metaM CE5125 x
boundary condition: false
constant: false
name: (2S)-pristanoyl-CoA
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
type: Species
initial amount: NaN

metaR ME1m
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
reversible: false
product: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
name: malic enzyme (NAD), mitochondrial

metaR EX gq1b hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GQ1b (homo sapiens) exchange
type: Reaction

metaR r2312
kinetic law: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction

metaM elaidcrn c
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
initial amount: NaN
type: Species
constant: false
is: HMDB06464
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Elaidic carnitine

metaM gal e
constant: false
type: Species
name: D-Galactose
initial concentration: 1.0
is: CHEBI:0
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
is: C00124
is: HMDB00143
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM dcholcoa r
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
initial concentration: 1.0
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:28701
type: Species
is: SBO:0000247

metaM lnlncg c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
initial amount: NaN
constant: false
name: gamma-linolenate
is: SBO:0000247
is: HMDB03073
boundary condition: false
type: Species

metaM ala D c
boundary condition: false
is: CHEBI:15570
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: D-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: SBO:0000247
is: HMDB01310
initial concentration: 1.0

metaR UMPK7n
reversible: true
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
name: UMP kinase (dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_3633fdcd_bc79_48a2_8233_2ab014aeed17
is: SBO:0000252
is: B7Z792
has only substance units: false
name: NDUFS2
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4720
type: Species

metaR r2311
product: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_56047687_0efc_4c53_9501_b32311a732f3
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q7GXY8
name: COX1
constant: false
is encoded by: hsa:4512
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f21802a5_1a80_4871_9dda_cf1327eaa95b
is encoded by: hsa:2877
initial concentration: NaN
type: Species
has only substance units: false
is: P18283
initial amount: NaN
name: GPX2
constant: false
boundary condition: true
is: SBO:0000252

metaR r1569
product: MODEL1310110050#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_9bd19d86_45c8_48d9_831b_55aa34683e5d
initial concentration: NaN
name: _AA081045_1_e
constant: false
is encoded by: hsa:AA081045
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM accoa c
is: SBO:0000247
is: CHEBI:57288
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
type: Species
name: Acetyl-CoA
boundary condition: false
has only substance units: false
is: HMDB01206
constant: false
initial concentration: 1.0

metaR r1568
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
reversible: true
fast: false

metaM itacon m
boundary condition: false
type: Species
name: itaconate(2-)
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial amount: NaN
constant: false
is: CHEBI:17240
initial concentration: 1.0
has only substance units: false
is: HMDB02092

http://identifiers.org/biomodels.db/MODEL1310110050#_b7413f1a_8128_4b60_b30c_3770ba37d8e6
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: DGAT2
is encoded by: hsa:84649
is: Q96PD7
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM xylt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02917
name: xylitol
is: CHEBI:17151
has only substance units: false

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM thcholstoic x
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
has only substance units: false
constant: false
is: CHEBI:18402
is: HMDB03873
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

metaR NDPK9
is: SBO:0000176
reversible: true
reactant: MODEL1310110050#
name: nucleoside-diphosphate kinase (ATP:IDP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_16d5eb52_e197_46d6_848b_b2d6dd9cf278
is: P20933
is: SBO:0000252
is encoded by: hsa:175
boundary condition: true
name: AGA
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaR CYTK14n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,CTP),nuclear
reversible: true
is described by: ECO:0000269
product: MODEL1310110050#

metaR THMMPt4
fast: false
modifier: MODEL1310110050#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110050#
name: Thiamine monophosphate transport in via anion antiport
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10542220,PMID:14770311 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110050#

metaM gt1c hs g
is: SBO:0000247
name: GT1c
initial amount: NaN
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
is: CHEBI:28648
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_642bbb6f_30f8_4a5f_aaf4_63e85ffea39c
name: NDUFA3
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4696
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is: O95167

metaM crm hs l
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
name: N-acylsphingosine
is: CHEBI:52639
initial amount: NaN

metaM ile L e
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
has only substance units: false
type: Species
is: HMDB00172
is: CHEBI:17191
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: L-isoleucine

metaR RE1342C
product: MODEL1310110050#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
name: RE1342
fast: false
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#

metaR r1567
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM arach e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: HMDB02212
name: arachidate
constant: false
is: CHEBI:32360
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_2daa1a11_4f03_4edf_ae05_b935cd639c99
is: Q16790
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: CA9
has only substance units: false
is encoded by: hsa:768

http://identifiers.org/biomodels.db/MODEL1310110050#_4dd84f7e_e79d_4689_aa81_040acf7ced47
is encoded by: hsa:411
is: A8K4A0
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: ARSB

metaM ala D e
constant: false
initial concentration: 1.0
is: CHEBI:15570
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
is: HMDB01310
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM Lcystin c
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16283
is: HMDB00192
name: L-cystine

metaR KCCt
is described by: ECO:0000269
name: K+-Cl- cotransport
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD

metaR CYTK7n
modifier: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (CMP,UTP),nuclear
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR GLYCTDle
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
reversible: true
is described by: ECO:0000134
name: difussion of glycerol accross the brush border membrane
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR FOLt2le
kinetic law: MODEL1310110050#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110050#
fast: false
type: Reaction
product: MODEL1310110050#
name: folate transport via anion exchange
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_d6984cbd_ed9b_4c36_8a27_955ce172830b
constant: false
boundary condition: true
name: LEFTY1
is encoded by: hsa:10637
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: O75610
has only substance units: false

metaM m5masnC g
is: HMDB06814
boundary condition: false
type: Species
is: CHEBI:58401
constant: false
is: SBO:0000247
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
notes: FORMULA: C52H87N2O40X CHARGE: 0
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_e8fc10c4_98a2_4aa1_9484_860345c637b3
is encoded by: hsa:471
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ATIC
type: Species
has only substance units: false
constant: false
is: P31939

metaR r1566
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#

metaM dcdp m
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:58593
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01245
name: dCDP(3-)
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaM 3mox4hpac m
is: HMDB05175
type: Species
initial concentration: 1.0
is: CHEBI:28111
has only substance units: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_c0553175_8542_45c3_9af2_e29647605642
is: P23434
has only substance units: false
constant: false
name: GCSH
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2653

metaM 3dhguln c
is: HMDB06334
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: 3-dehydro-L-gulonate
initial amount: NaN
is: CHEBI:57655
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_ef0ca879_6e4b_43c0_82e1_84946215f963
is encoded by: hsa:3158
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: HMGCS2
type: Species
has only substance units: false
is: P54868

metaR r1678
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
is: SBO:0000185

metaM pyr m
initial amount: NaN
is: CHEBI:15361
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
constant: false
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0
is: SBO:0000247
is: C00022
is: HMDB00243
name: pyruvate
type: Species

metaR r1565
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

metaM arach c
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
name: arachidate
initial amount: NaN
is: HMDB02212
is: CHEBI:32360
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

metaR SUCD1m
product: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
type: Reaction
reversible: true
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
fast: false
name: succinate dehydrogenase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110050#

metaR PAIL4P HStn
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
is: SBO:0000185
reactant: MODEL1310110050#

metaM mgacpail hs r
has only substance units: false
boundary condition: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: SBO:0000247
is: CHEBI:7896
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: HMDB00220
is: C00249

metaM dcdp n
initial concentration: 1.0
type: Species
has only substance units: false
name: dCDP(3-)
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
is: HMDB01245
constant: false
is: CHEBI:58593
initial amount: NaN

metaM C02528 c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:36234
is: HMDB00518
boundary condition: false
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN
name: chenodeoxycholate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_4d9cad36_7b7a_4c27_a114_94b0e6d8e526
constant: false
name: SLC25A1
initial concentration: NaN
is encoded by: hsa:6576
boundary condition: true
is: D9HTE9
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM ile L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
constant: false
is: CHEBI:17191
initial concentration: 1.0
name: L-isoleucine
is: HMDB00172
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM acetone c
is: SBO:0000247
is: CHEBI:15347
is: HMDB01659
initial amount: NaN
initial concentration: 1.0
name: acetone
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
boundary condition: false
type: Species

metaR r1564
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110050#

metaR CSPG Etly
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110050#
fast: false
name: chondroitin sulfate E transport, extracellular to lysosome
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_09df8358_4fbb_4afc_a8fb_e1340ad960d7
has only substance units: false
is encoded by: hsa:6391
type: Species
is: Q99643
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: SDHC

metaM hdcea c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB03229
type: Species
is: CHEBI:32372
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false

metaM strdnccoa m
name: stearidonyl coenzyme A
boundary condition: false
is: C16163
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r1563
product: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#

metaM hcys L c
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
initial concentration: 1.0
is: SBO:0000247
is: HMDB00742
name: L-homocysteine
boundary condition: false
is: CHEBI:17588
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_aff9641d_e9f8_4267_b93d_cf28ac8a7594
type: Species
is: B2RAT6
is encoded by: hsa:2592
name: GALT
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM amp e
name: AMP
constant: false
type: Species
is: CHEBI:456215
boundary condition: false
is: HMDB00045
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00020
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR PHCHGSm
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reactant: MODEL1310110050#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true
is described by: ECO:0000000

metaR MCITS
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110050#
name: 2-methylcitrate synthase
product: MODEL1310110050#
is: SBO:0000176

metaR GCCbim
reactant: MODEL1310110050#
reversible: false
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000269
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10

http://identifiers.org/biomodels.db/MODEL1310110050#_dfe1c9dc_851f_43f3_9265_801a03247950
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3948
type: Species
name: LDHC
is: P07864

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB02917
name: xylitol
boundary condition: false
is: CHEBI:17151
initial concentration: 1.0
constant: false

metaM crm hs g
initial amount: NaN
has only substance units: false
is: CHEBI:52639
type: Species
constant: false
is: SBO:0000247
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
initial concentration: 1.0

metaM lnlncg l
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:32391
name: gamma-linolenate
constant: false
initial concentration: 1.0

metaR PVD3
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
fast: false
reactant: MODEL1310110050#
reversible: true
name: Previtamin D3 formation
product: MODEL1310110050#
is described by: ECO:0000134
kinetic law: MODEL1310110050#
type: Reaction

metaR r1562
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
is: SBO:0000185

metaM dolichol L c
name: Dolichol, human liver homolog
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16091
notes: FORMULA: C1080H1768O10 CHARGE: 0
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_1b1d2c3c_f9d9_4ae8_9a46_911890c5bf95
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: O14986
is: SBO:0000252
boundary condition: true
name: PIP5K1B
type: Species
is encoded by: hsa:8395

http://identifiers.org/biomodels.db/MODEL1310110050#_5c7cdf73_9109_465a_8e4c_2ec651ffd222
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: ALDH3A2
type: Species
is encoded by: hsa:224
initial concentration: NaN
is: P51648
boundary condition: true

metaM sebacid c
initial amount: NaN
boundary condition: false
name: sebacicacid
is: HMDB00792
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C08277
constant: false
has only substance units: false
notes: FORMULA: C10H16O4 CHARGE: -2

metaR GLYt4
name: glycine transport via sodium symport
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
is described by: ECO:0000269
is: SBO:0000185
reversible: false
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false

metaR EX 3ivcrn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR PLA2 2e
reactant: MODEL1310110050#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
name: phospholipase A2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.4
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_344e2b6d_8a79_4258_825f_15200b3e5ca6
initial concentration: NaN
is: P80404
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:18
name: ABAT

http://identifiers.org/biomodels.db/MODEL1310110050#_55d78387_4d26_4dc8_bed4_f4c84e7cf72b
initial concentration: NaN
is: SBO:0000252
type: Species
name: HADHB
boundary condition: true
is: P55084
is encoded by: hsa:3032
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_d92cbb72_8500_4c64_b253_830ed920e5f5
initial concentration: NaN
type: Species
name: SLC22A3
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q5SYN6
constant: false
boundary condition: true
is encoded by: hsa:6581

metaM m6masnC g
initial concentration: 1.0
type: Species
is: HMDB06529
is: SBO:0000247
has only substance units: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: CHEBI:50570

http://identifiers.org/biomodels.db/MODEL1310110050#_fea83826_0cca_45de_9869_47db887def9a
initial concentration: NaN
initial amount: NaN
is: Q5TEK5
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5142
constant: false
name: PDE4B

metaR r1561
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_9e904214_7774_439b_abf2_853f6cc84569
is: SBO:0000252
is encoded by: hsa:6818
constant: false
is: Q1ET61
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: SULT1A3

metaR TETDEC2CRNe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR r2319
reversible: true
product: MODEL1310110050#
reactant: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM amp c
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: HMDB00045
name: AMP
is: CHEBI:3322
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: C00020
constant: false

metaM Lcystin e
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
is: CHEBI:16283
type: Species
is: HMDB00192
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR CYSGLYexR
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
name: L-cysteine/glycine reversible exchanger

metaR r0081
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
is: SBO:0000176
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000000
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
type: Reaction

metaM tdcrn e
initial concentration: 1.0
notes: FORMULA: C21H41NO4 CHARGE: 0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: myristoyl carnitine
constant: false
boundary condition: false
is: HMDB05066

metaM accoa r
is: HMDB01206
boundary condition: false
name: acetyl-CoA(4-)
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57288
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaR NDPK2
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP)

metaM pydxn c
initial concentration: 1.0
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
name: Pyridoxine
type: Species
constant: false
is: SBO:0000247
is: CHEBI:16709
initial amount: NaN
is: C00314
has only substance units: false
is: HMDB00239
boundary condition: false

metaR G16MT L
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
fast: false

metaM 3ivcoa m
is: HMDB06870
constant: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/11966188
name: 3-hydroxyisovalerylcoa
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: SBO:0000247
is: C05998
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR ST8SIA51g
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110050#
name: Beta-galactoside alpha-2,3-sialyltransferase

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaM oh1 c
is: C01328
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01039
boundary condition: false
type: Species
name: hydroxide ion
notes: FORMULA: HO CHARGE: -1
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_94dcce6f_7b0b_4ae5_974d_c9bfe23ac76d
boundary condition: true
name: CHST2
is encoded by: hsa:9435
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9Y4C5
constant: false

metaR PIPLCn
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
reversible: false
fast: false
name: phosphatidylinositol phospholipase C, nucleus

http://identifiers.org/biomodels.db/MODEL1310110050#_673a22c9_26c5_49da_be45_fedc93cd6378
has only substance units: false
type: Species
is encoded by: hsa:728226
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _728226_1_m
initial amount: NaN
constant: false

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaR Htx
product: MODEL1310110050#
name: H transporter, peroxisome
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
fast: false

metaR r1571
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true

metaM HC02214 c
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
name: prostaglandin-f1alpha
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaR C10DCc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR NDPK1
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:GDP)
is: SBO:0000176
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR S23T3g
is version of: http://identifiers.org/ec-code/2.4.99.6
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_87ded0ea_8931_44d3_8f6a_ebe3287c63bf
initial amount: NaN
constant: false
boundary condition: true
has part: P00326
has only substance units: false
name: ADH1B:ADH1C
is: SBO:0000297
initial concentration: NaN
type: Species
is encoded by: hsa:126

http://identifiers.org/biomodels.db/MODEL1310110050#_bb673c01_2821_4932_87de_c16b9aa07ced
is: SBO:0000252
initial concentration: NaN
name: ATP5D
is: P30049
constant: false
has only substance units: false
is encoded by: hsa:513
boundary condition: true
type: Species
initial amount: NaN

metaR GF6PTA
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2673.1) or (9945.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.6.1.16 Confidence Level: 4 AUTHORS: PMID:10198162,PMID:11842094,PMID:1460020 NOTES:
type: Reaction
reversible: false
name: glutamine-fructose-6-phosphate transaminase
is described by: ECO:0000269
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.6.1.16

http://identifiers.org/biomodels.db/MODEL1310110050#_e781e35b_0f81_4a0e_9fb2_423783eee960
initial concentration: NaN
has only substance units: false
name: GALK1
is: SBO:0000252
is encoded by: hsa:2584
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: P51570

metaR r0083
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110050#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
modifier: MODEL1310110050#
type: Reaction
reversible: true
fast: false

metaR NDPK4
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP)
product: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_54e820f8_4571_4a06_8ab0_3ec8f2a3ca57
is: SBO:0000297
has only substance units: false
constant: false
type: Species
name: ETFA:ETFB
initial amount: NaN
is encoded by: hsa:2109
has part: P38117
boundary condition: true
initial concentration: NaN

metaM pyr e
constant: false
type: Species
initial amount: NaN
is: CHEBI:15361
boundary condition: false
name: pyruvate
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_6c632461_b582_4645_a03a_42ae0d04d11d
boundary condition: true
has only substance units: false
is: P00338
is: SBO:0000252
is encoded by: hsa:3939
initial concentration: NaN
constant: false
name: LDHA
initial amount: NaN
type: Species

metaR PPPGOm
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
modifier: MODEL1310110050#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.4
product: MODEL1310110050#
is described by: ECO:0000304
name: protoporphyrinogen oxidase, mitochondrial

metaR RE2814R
is: SBO:0000176
fast: false
kinetic law: MODEL1310110050#
name: RE2814
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#

metaR ACOAD1fm
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reversible: false
is: SBO:0000176
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_960c6847_d23e_449f_b0e9_db262a7bb3eb
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ALDOA
initial amount: NaN
constant: false
is encoded by: hsa:226
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_012fd165_d51f_4681_a649_82759b0d04a2
type: Species
is: B3KT84
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:195814
is: SBO:0000252
initial concentration: NaN
name: SDR16C5

metaM HC02214 e
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:28852
has only substance units: false
type: Species
constant: false

metaR RE0512M
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110050#
name: RE0512

metaM oh1 e
initial concentration: 1.0
boundary condition: false
constant: false
name: hydroxide ion
notes: FORMULA: HO CHARGE: -1
is: SBO:0000247
initial amount: NaN
is: HMDB01039
is: C01328
has only substance units: false
type: Species

metaM tdcrn c
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: HMDB05066
name: myristoyl carnitine
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0

metaR ARACHCPT2
modifier: MODEL1310110050#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110050#
name: carnitine transferase
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#

metaR NDPK3
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP)

http://identifiers.org/biomodels.db/MODEL1310110050#_a9a3340c_19ab_48d3_96bc_3e186f60964c
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: Q9Y5P4
is encoded by: hsa:10087
boundary condition: true
initial amount: NaN
name: COL4A3BP

metaR RE1533M
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1533
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110050#

metaM thcholstoic r
is: SBO:0000247
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
is: CHEBI:18402
initial amount: NaN
type: Species

metaR r1570
kinetic law: MODEL1310110050#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110050#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_79db0649_b7e3_4089_a82c_59df89e1abd2
name: SUOX
is encoded by: hsa:6821
is: SBO:0000252
initial amount: NaN
constant: false
is: P51687
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM arachdcoa m
constant: false
is: HMDB06523
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:57368

metaR CITtbm
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
name: citrate transport, mitochondrial
is described by: ECO:0000269
fast: false
reactant: MODEL1310110050#

metaR DM atp c
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
fast: false
is: SBO:0000176
name: DM_atp(c)
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110050#

metaM hs deg14 l
boundary condition: false
type: Species
is: CHEBI:16126
name: heparan sulfate, degradation product 14
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
has only substance units: false
is: SBO:0000247

metaR EX gp1calpha hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GP1c alpha (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_8367834f_03f5_48fc_ac1a_578b5f4c1a40
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:T83654
initial concentration: NaN
name: _T83654_1_e
boundary condition: true
is: SBO:0000252

metaR ARACHCPT1
fast: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
type: Reaction
reversible: false

metaR NDPK6
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#

metaM pyr c
is: C00022
boundary condition: false
constant: false
is: CHEBI:15361
initial amount: NaN
type: Species
name: pyruvate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
is: HMDB00243
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324

metaR RE2998M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110050#
reversible: false
name: RE2998
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR B3GALT3g
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110050#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.79
name: Beta-1,3-galactosyltransferase 3
type: Reaction
modifier: MODEL1310110050#
product: MODEL1310110050#

metaR r0085
reactant: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110050#
product: MODEL1310110050#

metaM amp m
constant: false
is: CHEBI:456215
initial amount: NaN
has only substance units: false
is: HMDB00045
boundary condition: false
initial concentration: 1.0
name: AMP(2-)
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species

metaM c81coa c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C05276
is: HMDB03949
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
type: Species
name: octenoylcoa

metaM c6dc x
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: adipoyl carnitine
constant: false
type: Species
is: HMDB04047
initial amount: NaN
is: C14143
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247

metaR r0706
kinetic law: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is version of: http://identifiers.org/ec-code/1.3.99.10
reactant: MODEL1310110050#
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110050#
fast: false
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_42d022d7_4333_493e_ab22_6602fd58450c
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _NM_013421_1_e
is encoded by: hsa:NM 013421
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaM hexdiac r
type: Species
notes: FORMULA: C16H28O4 CHARGE: -2
is: HMDB00672
boundary condition: false
is: C08260
initial concentration: 1.0
has only substance units: false
name: hexadecanediocacid
is: SBO:0000247
constant: false
initial amount: NaN

metaR NDPK5
is: SBO:0000176
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reactant: MODEL1310110050#
name: Nucleoside-diphosphate kinase (ATP:dGDP)
modifier: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR r0084
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
fast: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR NTD3
reactant: MODEL1310110050#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
modifier: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269
name: 5'-nucleotidase (dCMP)
is: SBO:0000176
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaR FAOXC15ATPx
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaR AG13T10g
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: false
fast: false
modifier: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110050#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110050#_916bc9a3_f003_4a49_8287_df109d4457c9
initial concentration: NaN
name: NME1
is: P15531
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110050#_fb37cdf8_1015_4496_843e_58d93fc9c15a
is encoded by: hsa:64077
has only substance units: false
boundary condition: true
constant: false
name: LHPP
initial concentration: NaN
is: Q9H008
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_3d8039f1_d858_4994_abec_d6268ea1ed66
has only substance units: false
is encoded by: hsa:84701
initial amount: NaN
type: Species
initial concentration: NaN
is: Q96KJ9
constant: false
name: COX4I2
boundary condition: true
is: SBO:0000252

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM dhap x
is: C00111
has only substance units: false
boundary condition: false
is: HMDB01473
is: http://identifiers.org/pubchem.compound/3411
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: Dihydroxyacetone phosphate
is: CHEBI:57642
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_af0c9d6a_a3ed_42fb_ae61_f14b0739e70a
initial amount: NaN
name: INPP5J
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is: Q15735
is encoded by: hsa:27124
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_f1f72883_dff9_4286_84f8_eddf59164407
initial amount: NaN
is: SBO:0000252
type: Species
name: ADCY6
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:112
boundary condition: true

metaR NDPK8n
reactant: MODEL1310110050#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
fast: false
is described by: ECO:0000304
modifier: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_e5d4188b_ddac_4d29_a378_b72a347f19b7
is: SBO:0000252
initial concentration: NaN
constant: false
name: _AI924226_1_m
initial amount: NaN
type: Species
is encoded by: hsa:AI924226
boundary condition: true
has only substance units: false

metaR NDPK8
type: Reaction
product: MODEL1310110050#
name: Nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_67e92a16_9216_4b1c_873c_40e6601b8889
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaM akg x
name: 2-oxoglutarate(2-)
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
initial concentration: 1.0
boundary condition: false
is: CHEBI:16810
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaM dolmanp L r
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_793b2768_77ea_4c14_8734_393450efe5cd
is encoded by: hsa:349565
is: Q96T66
boundary condition: true
has only substance units: false
name: NMNAT3
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_5b6f18dc_6b6c_4026_a6fb_79262607ddc0
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: ALG8
is: A6NDW6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:79053

http://identifiers.org/biomodels.db/MODEL1310110050#_fcf34639_8516_4309_a4ec_3faae0b879cc
name: ACSL3
has only substance units: false
is: O95573
is encoded by: hsa:2181
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX gt1a hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GT1a (homo sapiens) exchange
type: Reaction

metaR TCHOLAtx
reversible: true
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000185
name: bile acid intracellular transport
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR NDPK7
fast: false
is described by: ECO:0000269
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dCDP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR MI1PP
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
kinetic law: MODEL1310110050#
name: myo-inositol 1-phosphatase
is described by: ECO:0000269
modifier: MODEL1310110050#
product: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false
type: Reaction
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_4a3911db_2df3_4930_a085_ce3cbe5630e6
is encoded by: hsa:763
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P35218
type: Species
name: CA5A
is: SBO:0000252
has only substance units: false
constant: false

metaM thcholstoic m
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:18402
is: HMDB03873

metaR NTD1
is: SBO:0000176
reversible: false
name: 5'-nucleotidase (dUMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000269
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_8e17abcb_4bfa_442f_8436_af0bd81cc630
boundary condition: true
is encoded by: hsa:W87865
has only substance units: false
is: SBO:0000252
name: _W87865_1_c
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

metaR r0086
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.3
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
modifier: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_95183da0_281f_4c22_8c09_b2440bde34f6
initial concentration: NaN
type: Species
name: RPIA
is: P49247
boundary condition: true
has only substance units: false
is encoded by: hsa:22934
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_6a36f745_3c79_4957_8fe8_ec5005264f07
is: SBO:0000252
constant: false
name: PCYT1B
initial amount: NaN
type: Species
initial concentration: NaN
is: E9PD84
has only substance units: false
boundary condition: true
is encoded by: hsa:9468

metaR NTD8
product: MODEL1310110050#
name: 5'-nucleotidase (dGMP)
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000269
is: SBO:0000176

metaR r1052
reversible: false
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
name: Vesicular transport

metaR BTNPLm
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.3.4.10
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
reactant: MODEL1310110050#

metaR EX 34hpp
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR r2321
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110050#

metaM CE1925 e
has only substance units: false
constant: false
is: CHEBI:57923
is: SBO:0000247
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
type: Species
initial amount: NaN
name: 3'-carboxy-alpha-chromanol
initial concentration: 1.0
boundary condition: false

metaR P4501B1r
is version of: http://identifiers.org/ec-code/1.14.14.1
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
name: cytochrome P450 1B1
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110050#
reversible: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR RE2625C
reversible: true
reactant: MODEL1310110050#
is: SBO:0000176
name: RE2625
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#

metaM dhdascb c
constant: false
name: dehydroascorbide(1-)
is: CHEBI:58070
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: SBO:0000247
is: HMDB01264
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_ff338e87_4580_4363_a164_f3ce0179e6b2
has only substance units: false
is encoded by: hsa:AA526438
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: _AA526438_1_c

metaM m7masnC g
has only substance units: false
initial amount: NaN
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: HMDB06814
initial concentration: 1.0
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58401

metaM amp x
type: Species
has only substance units: false
constant: false
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
is: C00020
name: AMP
initial concentration: 1.0
is: SBO:0000247
is: HMDB00045
initial amount: NaN

metaM formcoa x
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: formyl-CoA(4-)
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
is: HMDB03419
boundary condition: false
is: CHEBI:57376
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_9c9938be_4220_44b9_a24e_549f0e4da220
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: B3KTQ4
is encoded by: hsa:8706
constant: false
name: B3GALNT1

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM 3ivcoa c
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: C05998
has only substance units: false
name: 3-hydroxyisovalerylcoa
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM 2mop m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
boundary condition: false
is: HMDB01172
constant: false
name: 2-methyl-3-oxopropanoate
type: Species
has only substance units: false
is: CHEBI:57700

metaR GLUt2m
reversible: true
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110050#
name: L-glutamate reversible transport via proton symport, mitochondrial
modifier: MODEL1310110050#
fast: false
product: MODEL1310110050#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_e6fa9236_17e9_4a24_b0d6_546b709d43e2
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: P28330
is encoded by: hsa:33
boundary condition: true
name: ACADL
initial amount: NaN
type: Species

metaR r2322
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction

metaR NACHEXA3ly
type: Reaction
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110050#
modifier: MODEL1310110050#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
reversible: false

metaR 2MCITt
type: Reaction
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
name: 2-methylcitrate transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reversible: true

metaR GLYPROPEPT1tc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylproline by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR M4MPDOL Lter
reversible: false
name: m4mpdol flippase
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_12e937ec_89e4_49ea_83cb_16493cb94959
name: RRM1:RRM2
initial concentration: NaN
has only substance units: false
has part: P31350
is encoded by: hsa:6241
has part: P23921
boundary condition: true
constant: false
is encoded by: hsa:6240
initial amount: NaN
is: SBO:0000297
type: Species

metaR AHEXASE2ly
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal

metaR L LACt2r
fast: false
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
name: L-lactate reversible transport via proton symport
reactant: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110050#

metaR Htr
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
name: H transporter, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185

metaM hs deg20 l
is: SBO:0000247
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
has only substance units: false
name: heparan sulfate, degradation product 20
is: CHEBI:16126
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_eedcdfa0_d8bf_4f54_abff_21fd041d315c
is encoded by: hsa:125061
initial concentration: NaN
name: AFMID
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: Q63HM1
constant: false
initial amount: NaN

metaM creat e
is: HMDB00064
is: CHEBI:16919
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial amount: NaN
name: creatine

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR RE1254C
is: SBO:0000176
fast: false
name: RE1254
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR NTD6
is: SBO:0000176
reversible: false
modifier: MODEL1310110050#
is described by: ECO:0000134
fast: false
product: MODEL1310110050#
name: 5'-nucleotidase (dAMP)
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

http://identifiers.org/biomodels.db/MODEL1310110050#_0639bedc_f578_44c2_b1a2_6036d8b1f88c
is: P14060
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: HSD3B1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3283

metaR PIPLC
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
is described by: ECO:0000000
name: phosphatidylinositol phospholipase C
type: Reaction
is: SBO:0000176
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_6f7ea0d5_1d89_48e3_8780_9ce1fb673a8a
initial concentration: NaN
name: FASN
initial amount: NaN
is encoded by: hsa:2194
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is: P49327

http://identifiers.org/biomodels.db/MODEL1310110050#_9f3d7952_4149_4c36_91fb_d23c0f137071
is: SBO:0000252
is: P48448
has only substance units: false
name: ALDH3B2
is encoded by: hsa:222
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_96864d5e_acfa_45c7_9cb0_c1d9c0133bb8
initial concentration: NaN
name: PPT1
is: Q6FGQ4
is encoded by: hsa:5538
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaR DTMPK
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.9
name: dTMP kinase
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_a0bc5787_f6f1_47e3_87ab_99ba8c257d6f
is encoded by: hsa:29920
name: PYCR2
type: Species
is: Q96C36
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM xoldioloneh c
has only substance units: false
initial concentration: 1.0
is: CHEBI:2288
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
is: HMDB06887
type: Species
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR EBP1r
is version of: http://identifiers.org/ec-code/5.3.3.5
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110050#
product: MODEL1310110050#
reversible: false
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_2116064b_8a40_4f2c_b8ea_3dd1fbe2d864
is encoded by: hsa:761
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: P07451
boundary condition: true
name: CA3
initial concentration: NaN

metaR r2320
type: Reaction
product: MODEL1310110050#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true

metaR GLCAASE7ly
reversible: false
reactant: MODEL1310110050#
name: beta-glucuronidase, lysosomal
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#

metaR XOL7AH2tm
name: lipid, flip-flop intracellular transport
product: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaR NTD5
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
name: 5'-nucleotidase (dTMP)
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
reactant: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_af359db8_4bea_4d63_97d6_fe6d80285287
name: AMT
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:275
constant: false
initial concentration: NaN
is: P48728

metaR r1453
fast: false
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110050#
reversible: true
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_3e5a78c2_6656_442d_af45_733ea8b408b9
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI631997
name: _AI631997_1_m
type: Species

metaM estradiol e
initial concentration: 1.0
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:16469
constant: false
boundary condition: false
name: estradiol
is: HMDB00151
type: Species

metaR 4MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110050#
fast: false
name: Transport of 4-methyl-2-oxopentanoate
is: SBO:0000185

metaR r1116
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110050#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
type: Reaction
product: MODEL1310110050#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_213047b7_62bf_48a4_9585_0324028c3c01
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: DDC
is encoded by: hsa:1644
has only substance units: false
constant: false
is: Q53Y41

metaR NDP7g
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110050#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
fast: false
is described by: ECO:0000269
reactant: MODEL1310110050#
is: SBO:0000176
reversible: false
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_9ec3b6f3_edb3_4615_8be6_feaf6519bad2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5294
has part: Q9UBK5
has part: P48736
name: HCST:PIK3CG
is encoded by: hsa:10870
type: Species
constant: false
boundary condition: true
is: SBO:0000297

metaR EX gd1c hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GD1c (homo sapiens) exchange
type: Reaction

metaM accoa m
constant: false
name: Acetyl-CoA
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: HMDB01206
is: CHEBI:57288
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaR CYSSNAT5tc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_dbd6d996_2e4b_4ada_bc22_2cf3d7ad3a91
name: PIK3R3
initial amount: NaN
has only substance units: false
is: Q92569
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8503
is: SBO:0000252
type: Species

metaM creat c
initial concentration: 1.0
has only substance units: false
is: CHEBI:16919
is: HMDB00064
name: creatine
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species

metaR EHGLAT2m
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000304
kinetic law: MODEL1310110050#

metaM acgpail hs c
initial amount: NaN
is: SBO:0000247
type: Species
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57265

http://identifiers.org/biomodels.db/MODEL1310110050#_3faa7b72_254d_4456_bbf0_9a026f2e3162
is: SBO:0000297
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:518
boundary condition: true
initial amount: NaN

metaM ptdca c
type: Species
name: pentadecanoate
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/22169126
boundary condition: false
is: HMDB00826
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)

metaR G14T10g
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
type: Reaction
reversible: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110050#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110050#_4362351c_ec5e_42aa_91ec_d65f130bd268
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:1384
initial concentration: NaN
name: CRAT
has only substance units: false

metaR r1117
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
is: SBO:0000185
product: MODEL1310110050#
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_35b2cb80_97bd_4b9f_83dc_2121102d055d
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SYNJ2
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8871
is: O15056

metaM dcholcoa x
has only substance units: false
type: Species
is: CHEBI:28701
constant: false
boundary condition: false
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

metaR PRASCS
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM accoa n
is: HMDB01206
is: SBO:0000247
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
is: CHEBI:57288
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r1681
reversible: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR r1459
reactant: MODEL1310110050#
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reversible: true
type: Reaction

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
name: Sphingosine-1-phosphate lyase
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ

metaR NOt
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
name: NO transport (diffusion)
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
is: SBO:0000185

metaM thcholstoic c
type: Species
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
initial concentration: 1.0
boundary condition: false
is: HMDB03873

http://identifiers.org/biomodels.db/MODEL1310110050#_c0702b06_754c_4cb0_a3a4_da874f1b90ec
boundary condition: true
name: ME3
initial concentration: NaN
is encoded by: hsa:10873
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: Q6TCH8

http://identifiers.org/biomodels.db/MODEL1310110050#_f5360b2b_b6d7_4f40_b1eb_26a9b9165365
boundary condition: true
is encoded by: hsa:8693
initial amount: NaN
name: GALNT4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q8N4A0

metaM akg m
initial concentration: 1.0
is: CHEBI:16810
constant: false
name: 2-Oxoglutarate
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
type: Species
is: HMDB00208

metaM estradiol c
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00151
type: Species
initial concentration: 1.0
name: estradiol
boundary condition: false
is: CHEBI:16469

metaR MTHGXLt
name: Methylglyoxal transport (cytosol to extracellular)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
kinetic law: MODEL1310110050#
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185

metaR G14T9g
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reversible: false

metaM gal l
type: Species
name: D-galactose
is: HMDB00143
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_e2fe2c2b_f3bb_49bf_a190_a89af34d609e
has only substance units: false
boundary condition: true
is encoded by: hsa:56922
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: MCCC1
is: Q96RQ3
constant: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR C80CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_a333a726_b17d_4cc0_94ec_473cc8862f96
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ALDOB
is: P05062
is encoded by: hsa:229

metaR r1050
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
reversible: true
type: Reaction
is: SBO:0000185
name: Vesicular transport
is described by: ECO:0000000
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_c1361b65_16b0_43be_87fc_11319a2d49b2
is: P40394
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:131
initial concentration: NaN
is: SBO:0000252
type: Species
name: ADH7

metaM ptdca e
is: SBO:0000247
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
constant: false
name: pentadecanoate
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/22169126
is: HMDB00826
boundary condition: false
initial amount: NaN
type: Species

metaR EX onpthl LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: naphthalene epoxide exchange
type: Reaction

metaR PRO1xm
fast: false
name: proline oxidase (NAD), mitochondrial
is: SBO:0000176
product: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
is described by: ECO:0000254
reversible: false
reactant: MODEL1310110050#

metaM amp r
name: AMP
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:456215
is: HMDB00045
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

http://identifiers.org/biomodels.db/MODEL1310110050#_41d340aa_2e57_4a88_8a37_3f3e7f1c47e9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3251
name: HPRT1
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: P00492
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_84ff4436_3b09_420c_b5f7_edc1bb6ac643
constant: false
boundary condition: true
is encoded by: hsa:5140
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q13370
initial concentration: NaN
name: PDE3B
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_69385b71_adf1_4bd9_a6a5_0389d1f987b6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:11254
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC6A14
constant: false
has only substance units: false
is: Q9UN76

metaR r1051
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
reversible: true

metaR NTD9
modifier: MODEL1310110050#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
name: 5'-nucleotidase (GMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
is: SBO:0000176
reactant: MODEL1310110050#

metaR HSAT3ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reversible: false

metaR AGTim
is described by: ECO:0000269
product: MODEL1310110050#
type: Reaction
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
fast: false
reversible: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.44
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_48a445dc_e3c3_407c_8e6b_16c11cd31c69
initial concentration: NaN
is encoded by: hsa:127
is: SBO:0000252
type: Species
initial amount: NaN
name: ADH4
boundary condition: true
has only substance units: false
is: P08319
constant: false

metaR DAGKn hs
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
reversible: true
product: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#

metaR PFK
name: phosphofructokinase
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.11
type: Reaction
is: SBO:0000176
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaM h2o2 x
is: C00027
boundary condition: false
is: HMDB03125
is: CHEBI:16240
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: SBO:0000247
type: Species
name: Hydrogen peroxide
has only substance units: false
initial amount: NaN

metaM cspg b l
is: HMDB02183
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: CHEBI:36005
type: Species
boundary condition: false
initial concentration: 1.0

metaR r2324
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000

metaM acgam6p c
has only substance units: false
name: N-acetyl-D-glucosamine 6-phosphate(2-)
type: Species
initial amount: NaN
is: CHEBI:57513
is: HMDB01062
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
constant: false

metaR PI34P5K
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is version of: http://identifiers.org/ec-code/2.7.1.68
type: Reaction
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
reversible: false
modifier: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000

metaR r2196
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
reactant: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110050#

metaR r0393
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
reversible: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is version of: http://identifiers.org/ec-code/2.7.1.74
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176

metaM but e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: butyrate
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
is: HMDB00039

http://identifiers.org/biomodels.db/MODEL1310110050#_f557bacd_f666_4259_b8ec_d024a61f6464
constant: false
is encoded by: hsa:5211
initial concentration: NaN
is: SBO:0000297
boundary condition: true
initial amount: NaN
name: PFKL:PFKP
has part: Q7L2M7
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_acc9d14b_a385_4098_9b3d_1eebf1313385
is: P61457
name: PCBD1
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:5092
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR AFLATOXINte
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
type: Reaction
reversible: true
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
is: SBO:0000185

metaR GLNt4
fast: false
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
name: L-glutamine reversible transport via sodium symport
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
is described by: ECO:0000269

metaR r1557
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110050#

metaR r0394
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110050#
type: Reaction

metaR r2323
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaM gtp c
is: CHEBI:37565
name: GTP
type: Species
is: C00044
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01273
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0

metaM his L m
has only substance units: false
type: Species
is: CHEBI:15971
name: L-histidine
is: HMDB00177
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN
constant: false

metaR FAOXC2031836m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110050#
is described by: ECO:0000269
name: Beta oxidation of fatty acid
is: SBO:0000176
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#

metaM mthgxl c
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
boundary condition: false
is: CHEBI:17158
name: methylglyoxal
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB01167
has only substance units: false
is: SBO:0000247

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM xyl D c
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: aldehydo-D-xylose
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936
constant: false

metaR HSD3B7P
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.181

metaR r2195
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: SBO:0000185
reversible: true

metaM ksi pre36 g
name: keratan sulfate I biosynthesis, precursor 36
initial concentration: 1.0
is: CHEBI:28067
type: Species
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C247H394N17O210S11X CHARGE: -12

metaM HC02179 c
has only substance units: false
name: 20-hydroxy-arachidonate
constant: false
boundary condition: false
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR OCCOAtx
product: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
fast: false
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR r2326
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110050#

metaR ME2m
is described by: ECO:0000000
reversible: false
product: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.38
is: SBO:0000176
type: Reaction
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
name: malic enzyme (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.40
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF

metaM dolmanp L c
boundary condition: false
initial amount: NaN
is: CHEBI:15809
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
has only substance units: false
constant: false
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_75fba80e_fc52_44b0_aefc_ba529d6a7637
type: Species
has only substance units: false
constant: false
is encoded by: hsa:412
name: STS
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P08842

http://identifiers.org/biomodels.db/MODEL1310110050#_5d975485_27b4_49e9_9329_9121b9d8e057
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4702
has only substance units: false
name: NDUFA8
constant: false
is: B1AM93

metaR GALASE19ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110050#

metaR r2194
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR r0391
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
fast: false
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
is described by: ECO:0000000
is: SBO:0000176

metaR DOLDPP Ler
is version of: http://identifiers.org/ec-code/3.6.1.43
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
is: SBO:0000176
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
reactant: MODEL1310110050#
reversible: false
modifier: MODEL1310110050#

metaM leuktrB4 e
constant: false
is: HMDB01085
name: leukotriene B4(1-)
type: Species
is: CHEBI:57461
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_ca2e9985_225c_4ff7_a328_b74f3298020a
is encoded by: hsa:H17063
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _H17063_1_c
constant: false
type: Species

metaR r1559
kinetic law: MODEL1310110050#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
fast: false
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito

metaR XOL7AONEtr
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM zymstnl r
boundary condition: false
initial concentration: 1.0
name: 5alpha-cholest-8-en-3beta-ol
type: Species
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: CHEBI:16608
is: HMDB06841
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_937da413_f85f_4e36_b916_7fa53209e6b9
is: Q9H903
name: MTHFD2L
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:441024
constant: false
type: Species
has only substance units: false

metaR MALSO3tm
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110050#
fast: false
name: Malate:sulfite antiport, mitochondrial
is described by: ECO:0000269
reversible: true
is: SBO:0000185

metaM hexdiac c
initial amount: NaN
name: hexadecanediocacid
has only substance units: false
is: C08260
type: Species
notes: FORMULA: C16H28O4 CHARGE: -2
constant: false
boundary condition: false
is: HMDB00672
is: SBO:0000247
initial concentration: 1.0

metaR r2325
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110050#

metaM cala c
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: HMDB00026
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: N-carbamoyl-beta-alaninate
is: CHEBI:11892

http://identifiers.org/biomodels.db/MODEL1310110050#_f824d273_ec42_430c_9131_1ae51440af92
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:217
is: P05091
is: SBO:0000252
name: ALDH2
type: Species
initial amount: NaN
initial concentration: NaN

metaM mthgxl e
has only substance units: false
is: CHEBI:17158
boundary condition: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial amount: NaN
type: Species
name: methylglyoxal
constant: false
is: HMDB01167
initial concentration: 1.0
is: SBO:0000247

metaR r2193
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110050#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_5ec03599_ea20_4cd8_acd8_e37ac0598a57
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: ALDH4A1
is encoded by: hsa:8659
initial amount: NaN
boundary condition: true

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_7004ce01_413a_40e7_8b47_9211f3bb219e
type: Species
name: DCK
is encoded by: hsa:1633
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: P27707
has only substance units: false

metaR CSNAT3x
name: carnitine O-aceyltransferase, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000176
fast: false

metaR r0517
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is: SBO:0000176
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false

metaM HC02179 e
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:34306
initial amount: NaN
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false
is: SBO:0000247

metaM retinal cis 9 c
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
is: HMDB01358
is: SBO:0000247
constant: false
boundary condition: false
name: all-trans-retinal
has only substance units: false

metaR GK1
modifier: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
name: guanylate kinase (GMP:ATP)
product: MODEL1310110050#

metaM fad e
is: HMDB01248
initial amount: NaN
type: Species
constant: false
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
boundary condition: false
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16238

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_772c20ed_7723_4f89_a404_7e495304e44a
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: PLCB1
type: Species
is encoded by: hsa:23236
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_eab0d132_4d9e_4b72_8993_48d93e85d8aa
boundary condition: true
is: P55017
initial amount: NaN
initial concentration: NaN
name: SLC12A3
constant: false
is: SBO:0000252
is encoded by: hsa:6559
has only substance units: false
type: Species

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Glycerol 3-phosphate
is: HMDB00126
is: C00093
boundary condition: false
initial amount: NaN
has only substance units: false

metaM ins c
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: HMDB00195
name: Inosine
type: Species
initial amount: NaN
is: SBO:0000247
is: C00294
initial concentration: 1.0
constant: false
is: CHEBI:17596
boundary condition: false
has only substance units: false

metaM lys L x
type: Species
constant: false
name: L-lysinium(1+)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
is: CHEBI:32551
has only substance units: false
is: HMDB00182

metaM leuktrB4 c
is: SBO:0000247
boundary condition: false
is: CHEBI:57461
is: HMDB01085
type: Species
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
name: leukotriene B4(1-)
initial concentration: 1.0
constant: false
initial amount: NaN

metaR RE2677C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
product: MODEL1310110050#
name: RE2677
fast: false
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR 10FTHFtm
product: MODEL1310110050#
is: SBO:0000185
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

metaR UDPGALtg
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true
name: UDP-Gal Golgi transport via CMP antiport
product: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000269

metaM so4 l
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaR PSYGCHe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_15cb5f3e_3b03_4e25_b87e_45c162c3c727
is: P27987
is: SBO:0000252
name: ITPKB
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:3707
has only substance units: false

metaR r2327
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM damp c
is: HMDB00905
name: dAMP(2-)
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: CHEBI:58245
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_4d879b50_c530_4cda_a7d4_ed38175a9bda
has only substance units: false
type: Species
is encoded by: hsa:1103
boundary condition: true
is: D3DX95
is: SBO:0000252
constant: false
name: CHAT
initial amount: NaN
initial concentration: NaN

metaR HESTRATRIOLtr
product: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
type: Reaction
name: hydroxylated estrogen derivative transport
reversible: true
reactant: MODEL1310110050#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_74566752_42af_4022_9080_e3adedea611c
boundary condition: true
initial concentration: NaN
name: CYP2A13
constant: false
type: Species
is: Q16696
is: SBO:0000252
is encoded by: hsa:1553
has only substance units: false
initial amount: NaN

metaR 10FTHFtl
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD, IT
is: SBO:0000185
fast: false
name: 10-Formyltetrahydrofolate lysosomal transport via diffusion
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true

metaR r1492
type: Reaction
name: Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
reactant: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#

metaM so4 m
is: CHEBI:16189
boundary condition: false
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: sulfate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_aa2329b5_8d16_4719_9a8c_6bcf875c0c2a
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4731
is: P56181
name: NDUFV3
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM m8masn g
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: C05876

metaM but c
initial concentration: 1.0
is: HMDB00039
boundary condition: false
has only substance units: false
is: CHEBI:17968
initial amount: NaN
name: butyrate
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
type: Species

metaM eaflatoxin c
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: aflatoxin B1 exo-8,9-epoxide
notes: FORMULA: C17H12O7 CHARGE: 0 INCHI: InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1
is: CHEBI:30725
is: HMDB06558
initial amount: NaN
is: SBO:0000247

metaR G14T7g
is described by: ECO:0000000
modifier: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
product: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR GALt4
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
name: galactose transport via sodium symport
kinetic law: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
reversible: true
type: Reaction

metaM ac e
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
is: CHEBI:30089
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00042
type: Species
boundary condition: false
initial amount: NaN
name: acetate

metaR r0181
fast: false
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_7d087dff_b49f_4300_bccd_e9603e6d09fe
name: ACOX1
initial amount: NaN
has only substance units: false
is: Q15067
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51
type: Species
boundary condition: true
constant: false

metaM gtp e
is: CHEBI:37565
name: GTP(4-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
boundary condition: false
constant: false
is: HMDB01273

metaM lpam m
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species
constant: false
initial concentration: 1.0
name: lipoamide
is: HMDB00962
boundary condition: false
is: CHEBI:17460
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r0730
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
fast: false

metaR SCPx
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000269
name: peroxisomal thiolase 2
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false

metaR r2329
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM m2emgacpail hs r
initial amount: NaN
constant: false
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
type: Species
is: C00080
boundary condition: false
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110050#_44d425cd_e33c_4473_bad2_4a5efd805524
initial concentration: NaN
constant: false
name: CA7
initial amount: NaN
has only substance units: false
is encoded by: hsa:766
is: SBO:0000252
is: Q86YU0
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_fcc1181a_6f5d_4cf1_aac9_6987ad01e14a
initial amount: NaN
is encoded by: hsa:518
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ATP5G3
constant: false
boundary condition: true

metaR Htg
reversible: true
reactant: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110050#
is described by: ECO:0000000
name: proton diffusion (Golgi)

metaM xol25oh r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
initial concentration: 1.0
initial amount: NaN
name: 25-hydroxycholesterol
is: SBO:0000247
is: CHEBI:42977
boundary condition: false
type: Species
constant: false
is: HMDB06247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_95a1c50b_d4e0_43db_8956_443df89e9462
initial amount: NaN
constant: false
is: E9PH29
is encoded by: hsa:10935
name: PRDX3
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaM ksi e
is: CHEBI:17268
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: keratan sulfate I
is: SBO:0000247
is: HMDB00211
initial amount: NaN

metaR r1019
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110050#
type: Reaction
name: Postulated transport reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_0f52daac_29d9_499b_93d1_da2c8fa5ef6f
constant: false
initial concentration: NaN
is encoded by: hsa:196883
initial amount: NaN
name: ADCY4
has only substance units: false
is: Q8NFM4
type: Species
boundary condition: true
is: SBO:0000252

metaR FAS140COA
name: fatty-acyl-CoA synthase (n-C14:0CoA)
is described by: ECO:0000269
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
fast: false
reversible: false
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_9e87911e_be6b_4017_8b16_b6b07cf58055
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: SLC14A1
is: SBO:0000252
is encoded by: hsa:6563
is: G0W2N5

metaR AKR1D2
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.3
product: MODEL1310110050#
type: Reaction
fast: false
modifier: MODEL1310110050#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is described by: ECO:0000269
reactant: MODEL1310110050#

metaR r2437
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3

http://identifiers.org/biomodels.db/MODEL1310110050#_9871833a_1770_46f4_92ad_e67663c907fc
name: FASN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: P49327
type: Species
initial amount: NaN
is encoded by: hsa:2194

metaM adrn e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:53487
initial concentration: 1.0
is: HMDB02226
constant: false
name: adrenic acid
boundary condition: false
initial amount: NaN
type: Species

metaM dgchol e
is: HMDB00637
initial amount: NaN
constant: false
is: CHEBI:36252
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
type: Species
name: glycochenodeoxycholate
initial concentration: 1.0
boundary condition: false

metaR HESTRATRIOLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000000
name: hydroxylated estrogen derivative transport

http://identifiers.org/biomodels.db/MODEL1310110050#_a169863e_260a_43c2_9fa1_bb477333fdf8
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: _AL048840_1_c
initial amount: NaN
type: Species
is encoded by: hsa:AL048840
is: SBO:0000252

metaR r1018
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Transport reaction
fast: false
is: SBO:0000185
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000

metaM fad r
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
is: HMDB01248
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16238
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_a9c9d253_9dd1_4d88_9769_d651f8e245db
initial amount: NaN
is: SBO:0000252
name: NMNAT2
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:23057
type: Species
is: Q9BZQ4

metaR VALt5m
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110050#
name: Valine reversible mitochondrial transport
reactant: MODEL1310110050#
is: SBO:0000185
type: Reaction
fast: false
reversible: true

metaM cspg b e
is: SBO:0000247
is: CHEBI:17568
constant: false
is: C00106
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: HMDB00300
boundary condition: false
type: Species

metaM prostge1 c
name: prostaglandin E1(1-)
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: HMDB01442
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: CHEBI:57397

metaM nh4 n
is: HMDB00051
initial amount: NaN
name: ammonium
type: Species
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM pnto R e
initial amount: NaN
name: (R)-Pantothenate
constant: false
type: Species
is: SBO:0000247
is: HMDB00210
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568

metaR RTOTAL2FATPc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_c9fb091f_da21_4f9e_ac89_4fd0ef1c66ff
is encoded by: hsa:1327
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: COX4I1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P13073

metaM ins e
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
has only substance units: false
constant: false
name: Inosine
is: HMDB00195
type: Species
initial amount: NaN
is: CHEBI:17596
boundary condition: false
is: C00294
is: SBO:0000247

metaM ksi g
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
is: CHEBI:57255
initial concentration: 1.0
name: keratan sulfate I
type: Species
constant: false
is: HMDB01014
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_6bbbe3f4_be35_4390_a237_fa7346725b21
has only substance units: false
is encoded by: hsa:6718
name: AKR1D1
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: P51857
constant: false
is: SBO:0000252

metaR UGLCNACtg
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
kinetic law: MODEL1310110050#
name: UDP-GlcNAc Golgi transport via CMP antiport
product: MODEL1310110050#
is: SBO:0000185
fast: false

metaM retinal cis 9 r
name: all-trans-retinal
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:17898
initial amount: NaN
is: SBO:0000247
is: HMDB01358
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
has only substance units: false

metaR r1017
reactant: MODEL1310110050#
is: SBO:0000185
fast: false
name: Vesicular transport
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#

metaM adrn c
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
name: adrenic acid
is: SBO:0000247
is: HMDB02226
is: CHEBI:53487

metaM L2aadp c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00510
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
name: L-2-aminoadipate(1-)
is: SBO:0000247
is: CHEBI:58672

metaR r2439
reversible: false
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110050#
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2

metaM nh4 m
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:28938
boundary condition: false
name: Ammonium
type: Species
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
initial amount: NaN
is: C01342

metaR LAPCOAe
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110050#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000134
name: LAPCOAe

metaR GGLUCT
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.2.4
fast: false
reversible: false
product: MODEL1310110050#
reactant: MODEL1310110050#
name: gamma-glutamylcyclotransferase
type: Reaction
is: SBO:0000185

metaM dgchol c
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:36252
is: SBO:0000247
name: glycochenodeoxycholate
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_a8e01e41_b619_4692_932f_07aabc71c0d7
name: _728637_1_c
is encoded by: hsa:728637
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR ADK1m
is described by: ECO:0000269
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
fast: false
name: adenylate kinase, mitochondrial
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000176

metaR PEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reactant: MODEL1310110050#
is described by: ECO:0000000
name: phosphatidylethanolamine transport
fast: false
product: MODEL1310110050#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: true

metaR r1552
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaR MTHFR3
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
is version of: http://identifiers.org/ec-code/1.5.1.20
type: Reaction
is described by: ECO:0000134
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
is: SBO:0000176

metaR NAHCO3 HCLt
reversible: true
kinetic law: MODEL1310110050#
name: bicarbonate transport (HCl/NaHCO3 exchange)
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
fast: false
product: MODEL1310110050#
type: Reaction
is: SBO:0000185

metaM ksi pre5 g
has only substance units: false
is: CHEBI:28067
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 5
initial amount: NaN
notes: FORMULA: C101H164N7O75SX CHARGE: -2
type: Species

metaM malcoa c
is: CHEBI:57384
name: Malonyl-CoA
is: C00083
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01175
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
boundary condition: false
type: Species

metaR RE2655R
name: RE2655
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

metaM prostge1 e
is: SBO:0000247
type: Species
constant: false
name: prostaglandin E1(1-)
is: HMDB01442
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_cc68b38b_b4b2_45cd_a11f_128e2c9d8267
name: ATP5I
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:521
is: SBO:0000252
is: P56385
has only substance units: false
boundary condition: true
type: Species

metaM pnto R c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00210
initial concentration: 1.0
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
type: Species
constant: false
name: (R)-Pantothenate

metaR r1551
fast: false
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110050#

metaM retinal cis 13 r
has only substance units: false
is: HMDB06220
constant: false
is: CHEBI:45487
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
type: Species
name: 13-cis-retinal

metaR r0186
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
modifier: MODEL1310110050#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110050#
fast: false
reversible: false
product: MODEL1310110050#

metaR UMPK4n
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110050#
reversible: true
product: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (GTP),nuclear
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000176

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR NRPPHRtu
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110050#
type: Reaction
name: Norepinephrine uniport
is described by: ECO:0000269
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
reversible: true
fast: false
modifier: MODEL1310110050#

metaR APOCFm
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Apocarboxylase formation, mitochondrial
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5e0a10ad_3207_459b_9131_428bb5cfc1fd
is: SBO:0000252
constant: false
is: Q08828
has only substance units: false
name: ADCY1
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:107

http://identifiers.org/biomodels.db/MODEL1310110050#_88593a60_deb0_4a7e_89a9_55398cdd3df9
name: ACOT4
initial concentration: NaN
is: Q8N9L9
boundary condition: true
constant: false
is encoded by: hsa:122970
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_d0874cb2_ef55_4336_8dac_bbb3800a2158
constant: false
is: SBO:0000252
name: ALG3
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:10195

metaM glyc e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17754
is: HMDB00131
type: Species
name: Glycerol
is: C00116
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
has only substance units: false
boundary condition: false

metaR CYTK13n
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110050#
modifier: MODEL1310110050#
name: cytidylate kinase (dCMP,dATP),nuclear
type: Reaction
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM fad m
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
has only substance units: false
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
is: C00016
is: HMDB01248
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR URIt
is described by: ECO:0000269
product: MODEL1310110050#
reactant: MODEL1310110050#
name: uridine facilated transport in cytosol
type: Reaction
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110050#_a5eae777_a7e3_4ec1_8858_c965f47c31cd
is: Q9BVK2
is: SBO:0000252
is encoded by: hsa:79053
has only substance units: false
name: ALG8
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaR r1554
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction

metaM ksi pre14 g
constant: false
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 14
is: CHEBI:28067
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5

metaR r2433
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR PSP L
is version of: http://identifiers.org/ec-code/3.1.3.3
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
type: Reaction
name: phosphoserine phosphatase (L-serine)
is: SBO:0000176
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
reversible: false

metaR FAOXC2242046m
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
fast: false
name: Beta oxidation of long chain fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_b863611c_0a66_4c7f_abc3_f9497018cf40
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: MTHFD1L
is: SBO:0000252
initial concentration: NaN
is: B2RD24
is encoded by: hsa:25902
has only substance units: false

metaR r0390
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
reversible: true
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_fffc94ad_1b2f_4c5e_a31a_9197a82aefa7
type: Species
is encoded by: hsa:5298
name: PI4KB
is: Q9UBF8
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_4004ccd1_56a3_4aa9_a647_4053d507a9dd
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI971036
boundary condition: true
name: _AI971036_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_4a839dbc_a249_49f2_9c93_d0250993fde3
has only substance units: false
is: P48448
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ALDH3B2
is encoded by: hsa:222
type: Species

metaM cl c
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
boundary condition: false
type: Species
is: CHEBI:3966
name: Chloride
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00115
has only substance units: false

metaM m8masn r
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: C05876
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial amount: NaN
boundary condition: false

metaR r1553
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#

metaM thmmp e
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37575
is: HMDB02666
is: SBO:0000247
initial amount: NaN
name: thiamine(1+) monophosphate(2-)
type: Species
constant: false
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR PAIL45P HStn
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
product: MODEL1310110050#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_44fe94f4_a975_46e8_be79_8fce4ba14ab6
is: Q05C14
boundary condition: true
name: FOLR3
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:2352
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM h2o2 m
is: CHEBI:16240
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
is: HMDB03125
has only substance units: false
type: Species
is: C00027
initial amount: NaN
name: Hydrogen peroxide
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_0be88b23_0ea9_4bf5_8702_ec417c411a79
has only substance units: false
is encoded by: hsa:26503
is: Q9NRA2
boundary condition: true
name: SLC17A5
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

metaM xoltriol c
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial amount: NaN
is: HMDB01457
type: Species
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial concentration: 1.0
is: CHEBI:16496
constant: false
has only substance units: false

metaM glyc c
initial amount: NaN
constant: false
name: Glycerol
has only substance units: false
boundary condition: false
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
is: HMDB00131
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM HC01104 e
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61146
name: 4-nitrophenyl phosphate(2-)
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species

metaM lys L m
initial amount: NaN
is: CHEBI:32551
name: L-lysinium(1+)
type: Species
is: SBO:0000247
is: HMDB00182
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaR SERPT
kinetic law: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.50
is described by: ECO:0000269
fast: false
type: Reaction
name: serine C-palmitoyltransferase

metaM fum c
is: HMDB00134
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
boundary condition: false
name: Fumarate
is: C00122
is: CHEBI:29806
has only substance units: false
initial amount: NaN

metaM ac m
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
is: SBO:0000247
is: HMDB00042
initial concentration: 1.0
type: Species
name: acetate
is: CHEBI:30089
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_4477072f_2427_4301_8e7d_312f58ef795b
has only substance units: false
is: SBO:0000252
boundary condition: true
name: SLC22A2
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:6582
type: Species

metaR r1556
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_415a3e0f_0f6a_4058_9146_c3057480ca00
type: Species
is encoded by: hsa:4594
is: P22033
name: MUT
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR CYSTLEUrBATtc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR P45027A14m
is: SBO:0000176
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
kinetic law: MODEL1310110050#
is described by: ECO:0000269
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110050#
reversible: false

metaM L2aadp6sa c
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
is: HMDB01263
boundary condition: false
is: SBO:0000247
name: L-allysine
initial amount: NaN
constant: false
is: CHEBI:17917
type: Species
initial concentration: 1.0

metaM Lcyst c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: L-cysteate(1-)
is: CHEBI:58090
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
constant: false
type: Species
boundary condition: false
is: HMDB02757
has only substance units: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_f25095d5_4ad7_47c9_930e_2df315bb233a
has only substance units: false
is encoded by: hsa:AA177072
name: _AA177072_1_x
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM adrncrn c
is: CHEBI:16347
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C29H49NO4 CHARGE: 0
is: SBO:0000247
is: C00318
is: HMDB00062
boundary condition: false
name: Adrenyl carnitine
initial amount: NaN

metaM galside hs l
boundary condition: false
initial concentration: 1.0
type: Species
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
is: CHEBI:12947
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM lys L n
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
name: L-lysinium(1+)
is: CHEBI:32551
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00182
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_5d485984_88d6_4d97_8fbd_fc3ce04bd707
name: ST3GAL3
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:6487
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q96L53

metaM dmhptcrn m
initial concentration: 1.0
is: HMDB06320
initial amount: NaN
name: 2,6 dimethylheptanoyl carnitine
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3

metaM cl e
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
is: CHEBI:3966
type: Species
initial amount: NaN
boundary condition: false
name: Chloride
constant: false
is: SBO:0000247
is: C00115
initial concentration: 1.0

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM HC01162 c
initial amount: NaN
has only substance units: false
is: CHEBI:58376
is: SBO:0000247
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691

metaM thmmp c
is: C01081
initial concentration: 1.0
name: Thiamin monophosphate
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
boundary condition: false
constant: false
is: HMDB02666
initial amount: NaN
is: CHEBI:37575

metaR FAOXC12DCx
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR NRPPHRSULT
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
name: Norepinephrine Sulfotransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1

metaM uacgam c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
is: HMDB00290
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:57705
type: Species

metaM pyam5p c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
has only substance units: false
type: Species
is: HMDB01555
initial amount: NaN
name: Pyridoxamine 5'-phosphate
constant: false
is: C00647
initial concentration: 1.0
is: CHEBI:58451

metaR MI134PP
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.3.57
product: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
kinetic law: MODEL1310110050#
is: SBO:0000176
fast: false
reversible: false
name: inositol-1,3,4-trisphosphate 1-phosphatase
modifier: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_de9abccf_1549_405f_afb3_ec40169e197f
type: Species
name: NT5C
is encoded by: hsa:30833
boundary condition: true
is: Q8TCD5
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_2307c181_faf6_4343_ba00_bd4043c0ca09
is: F6VPY9
boundary condition: true
is encoded by: hsa:6546
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: SLC8A1
initial amount: NaN

metaM methf m
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: (6R)-5,10-methenyltetrahydrofolate
constant: false
is: CHEBI:57455
is: HMDB01354
boundary condition: false
initial amount: NaN

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_0e88d5bb_43cb_4730_a26e_a622a072fc40
constant: false
is encoded by: hsa:2878
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: P22352
initial concentration: NaN
name: GPX3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_e01775a9_73ed_4f51_adfa_3f7dd8d6dd43
is: SBO:0000252
has only substance units: false
constant: false
is: P31639
initial amount: NaN
name: SLC5A2
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:6524

metaR NADPtru
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
product: MODEL1310110050#
is described by: ECO:0000000
name: NADP transporter, endoplasmic reticulum
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_430de34c_516a_4da4_9e39_0a3beb23397b
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:10423
initial amount: NaN
is: A8K3L7
name: CDIPT
has only substance units: false
initial concentration: NaN

metaR ETOHt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
name: ethanol reversible transport
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110050#

metaM anth e
has only substance units: false
is: CHEBI:16567
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01123
constant: false
initial concentration: 1.0
name: anthranilate

http://identifiers.org/biomodels.db/MODEL1310110050#_0c753d23_0d9b_4e22_9a0a_2d160f793b73
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: P53004
is encoded by: hsa:644
name: BLVRA

metaR CYTK6n
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,CTP),nuclear
is described by: ECO:0000269
reversible: true
product: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110050#

metaR DMHPTCRNt
is: SBO:0000185
kinetic law: MODEL1310110050#
name: 2,6 dimethylheptanoyl crn transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
reversible: true

metaM gmp e
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247
type: Species
is: CHEBI:58115
name: GMP(3-)

metaR LEUPHELAT2tc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM nh4 e
constant: false
name: ammonium
boundary condition: false
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:28938
initial amount: NaN

metaR AG13T11g
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110050#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR r0739
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
modifier: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176

metaM glyc3p c
name: Glycerol 3-phosphate
boundary condition: false
is: CHEBI:57597
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
type: Species
initial amount: NaN
is: HMDB00126
is: C00093
initial concentration: 1.0

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR GGH 10FTHF5GLUl
type: Reaction
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF5GLU), lysosomal
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reactant: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_57dd97d8_c690_4656_9c26_f62dee208cdb
is: SBO:0000252
is encoded by: hsa:1716
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: DGUOK

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR r1020
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
reactant: MODEL1310110050#
reversible: true
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaM alaala e
notes: FORMULA: C6H12N2O3 CHARGE: 0
has only substance units: false
initial amount: NaN
name: D-Alanyl-D-alanine
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00725
initial concentration: 1.0

metaR GGH 6THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110050#
fast: false
type: Reaction
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110050#
name: Gamma-glutamyl hydrolase (6THF), extracellular
kinetic law: MODEL1310110050#
reversible: false

metaM phe L e
is: SBO:0000247
boundary condition: false
name: L-phenylalanine
constant: false
initial concentration: 1.0
type: Species
is: HMDB00159
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
has only substance units: false

metaR DOPASULT
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
product: MODEL1310110050#
type: Reaction
fast: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: Dopamine Sulfotransferase
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)

metaR GULN3D
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: L-gulonate 3-dehydrogenase
fast: false
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_202a7931_3889_4ee7_be35_fc27ef84e8da
is: P13866
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: SLC5A1
initial amount: NaN
is encoded by: hsa:6523
has only substance units: false
is: SBO:0000252

metaM tymsf c
initial amount: NaN
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
has only substance units: false
name: Tyramine O-sulfate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06409

http://identifiers.org/biomodels.db/MODEL1310110050#_13b1da3a_8498_48dc_b5d2_b78b1039f196
is: SBO:0000252
name: NDUFS5
is: Q6IBA0
is encoded by: hsa:4725
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_f743e918_ff5f_482d_83e9_6886474e588b
is encoded by: hsa:1606
is: P23743
has only substance units: false
type: Species
name: DGKA
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR CYTDt
modifier: MODEL1310110050#
fast: false
is: SBO:0000185
type: Reaction
name: cytidine facilated transport in cytosol
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00051
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:28938
name: Ammonium
is: C01342

metaM 13 cis retn r
name: 13-cis-retinoate
constant: false
is: http://identifiers.org/pubchem.compound/7847414
has only substance units: false
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: HMDB06219
is: D00348
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaR LAPCOAl
name: lysosomal acid phosphorylase (CoA)
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
fast: false
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110050#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110050#
is described by: ECO:0000304

metaR NDPK9n
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110050#
is described by: ECO:0000269
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110050#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110050#

metaR N2M2NMASNtly
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
name: n2m2nmasn transport, extracellular to lysosome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110050#
is: SBO:0000185

metaM gmp g
name: GMP(3-)
is: HMDB01397
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM anth c
boundary condition: false
is: CHEBI:16567
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
type: Species
initial amount: NaN
is: HMDB01123
initial concentration: 1.0
name: anthranilate
has only substance units: false
constant: false

metaR UGLT
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
reactant: MODEL1310110050#
reversible: true
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
is: SBO:0000176
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_32b3548a_dc80_4b2c_84d4_c04c7f5bf218
has only substance units: false
type: Species
name: ACADS
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:35
is: P16219
initial concentration: NaN
constant: false

metaM lnlncg r
name: gamma-linolenate
constant: false
is: CHEBI:32391
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB03073
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426

metaR RE0830C
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction
reversible: true
product: MODEL1310110050#
fast: false
name: RE0830
reactant: MODEL1310110050#

metaR r2443
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110050#
is described by: ECO:0000000
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction

metaM g3m8mpdol L r
initial amount: NaN
is: CHEBI:37568
is: HMDB01342
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
constant: false
is: C00459

http://identifiers.org/biomodels.db/MODEL1310110050#_9bbd61d5_cd31_4f48_9884_36d3de85749b
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: BAAT
has only substance units: false
is encoded by: hsa:570
is: Q14032
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_5ca26253_f578_4316_99bf_993e68c0cf64
type: Species
constant: false
initial concentration: NaN
name: PIGA
is encoded by: hsa:5277
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: B3KUV7

metaM acnam n
is: HMDB00230
name: N-acetylneuraminate
boundary condition: false
is: CHEBI:35418
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
initial concentration: 1.0

metaM HC00342 c
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16383

metaM HC02175 c
is: CHEBI:27689
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: caprate
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
type: Species
is: SBO:0000247
has only substance units: false

metaR RE1532M
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110050#
name: RE1532
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false

metaR SPHMYLNtg
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110050#
name: sphingomyelin intracellular transport
kinetic law: MODEL1310110050#
is: SBO:0000185

metaM cysam c
is: HMDB02991
has only substance units: false
type: Species
constant: false
name: cysteaminium
is: CHEBI:58029
initial amount: NaN
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM crm hs r
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: N-acylsphingosine
constant: false
is: CHEBI:52639
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_abe278f8_7688_483e_bb4c_b9509d10f9fc
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: GGT7
is encoded by: hsa:2686
boundary condition: true
is: A0PJJ9

metaM phe L c
is: SBO:0000247
name: L-phenylalanine
constant: false
is: HMDB00159
has only substance units: false
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17295

metaM arachcoa c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258
initial amount: NaN
type: Species
is: CHEBI:15527

metaR 3SALATAim
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
fast: false
reversible: false
is described by: ECO:0000304
reactant: MODEL1310110050#
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_d08ad44b_ba55_41d9_bdb5_62d377ef8e17
name: GALNT8
is: Q9NY28
has only substance units: false
type: Species
is encoded by: hsa:26290
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM galside hs c
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_a113adca_e38c_49ea_a2fa_2c8cf43f7624
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: Q02218
is: SBO:0000252
type: Species
is encoded by: hsa:4967
name: OGDH

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_cec95d52_7606_4ad9_8b1d_0f18ccd33503
boundary condition: true
name: CMAS
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:55907
is: SBO:0000252
is: Q8NFW8

http://identifiers.org/biomodels.db/MODEL1310110050#_d93ae97c_bbb0_4063_a56f_0b7122965819
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: PDE8A
initial concentration: NaN
is encoded by: hsa:5151
has only substance units: false
constant: false

metaM h2o2 c
constant: false
name: Hydrogen peroxide
is: SBO:0000247
is: HMDB03125
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00027
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
is: CHEBI:16240

http://identifiers.org/biomodels.db/MODEL1310110050#_55386b93_26dd_4a67_973e_eb8276fb7f2a
is: Q9H553
is encoded by: hsa:85365
boundary condition: true
initial amount: NaN
name: ALG2
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaM pro D e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
name: D-proline
is: CHEBI:16313
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: HMDB03411

metaR P4508B11r
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.95
kinetic law: MODEL1310110050#
reversible: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
name: sterol 12-alpha-hydroxylase
product: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_4cd16a5b_a0f0_4069_aa49_6f3bc789fd0e
boundary condition: true
initial amount: NaN
is: Q9H6R3
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79611
name: ACSS3

metaM dmhptcrn e
constant: false
has only substance units: false
type: Species
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 2,6 dimethylheptanoyl carnitine

metaM glyc R c
initial concentration: 1.0
name: D-glycerate
is: SBO:0000247
is: CHEBI:16659
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
constant: false
is: HMDB00139
has only substance units: false
type: Species

metaM pchol hs m
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
name: Phosphatidylcholine
initial amount: NaN
is: CHEBI:16110
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_d02ef222_83dd_4ded_8d00_984548b06178
is: SBO:0000297
initial amount: NaN
name: PIGF:PIGO
is encoded by: hsa:5281
has only substance units: false
constant: false
boundary condition: true
has part: Q07326
has part: Q8TEQ8
initial concentration: NaN
is encoded by: hsa:84720
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_6b56a4c4_739b_490a_bf29_570f0cd94824
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM homoval m
name: Homovanillate
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
type: Species
is: CHEBI:545959
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00118
boundary condition: false
constant: false

metaM HC01496 m
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28095
name: 2-Amino-3-oxoadipate
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_8bd1bed0_43d6_40cd_b3d9_4781fa28bf5f
constant: false
is: E7EX19
boundary condition: true
name: PIK3R1
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5295

http://identifiers.org/biomodels.db/MODEL1310110050#_95557d64_ec76_4037_a043_1012f2eaec00
boundary condition: true
is: Q16878
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1036
type: Species
name: CDO1
initial concentration: NaN
initial amount: NaN

metaR r1560
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110050#
fast: false

metaR HS1ly
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.10.1.1

http://identifiers.org/biomodels.db/MODEL1310110050#_295a6331_3573_4229_aca5_379a7ec630ab
name: _AA502753_1_m
is encoded by: hsa:AA502753
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM lys L e
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
is: CHEBI:32551
is: HMDB00182
type: Species
constant: false
name: L-lysinium(1+)

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_5199f5b1_9b49_42ef_984d_e130dd025996
has only substance units: false
is: P14618
type: Species
is encoded by: hsa:5315
boundary condition: true
name: PKM2
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR OCD11COACPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM dcdp c
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
type: Species
is: C00705
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: dCDP
is: HMDB01245
is: CHEBI:58593

http://identifiers.org/biomodels.db/MODEL1310110050#_09476dba_fd9e_44e4_b019_342f2de1c6dc
initial amount: NaN
is encoded by: hsa:11046
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: Q76EJ3
boundary condition: true
is: SBO:0000252
name: SLC35D2

metaM pro D c
initial amount: NaN
is: HMDB03411
name: D-proline
is: CHEBI:16313
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_61ce87f6_8fdd_48d3_9b89_e863ac080a6c
name: ACAT1
initial amount: NaN
initial concentration: NaN
type: Species
is: P24752
constant: false
boundary condition: true
is encoded by: hsa:38
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_ae529d3b_dc7e_4cce_9a55_dc70f8e79714
name: PIGV
is: Q9NUD9
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:55650
constant: false
type: Species
is: SBO:0000252

metaM h2o2 e
name: hydrogen peroxide
constant: false
is: SBO:0000247
is: HMDB03125
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16240
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaR PROSTGI2t
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
name: Prostaglandin I2 transport
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

metaM chlstol r
constant: false
has only substance units: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
boundary condition: false
is: CHEBI:16290
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: HMDB06842
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM his L e
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15971
boundary condition: false
is: HMDB00177
has only substance units: false
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: SBO:0000247
name: L-histidine

metaM dmhptcrn c
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
is: HMDB06320
name: 2,6 dimethylheptanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110050#_de8d9f22_176b_4472_8a14_270c09071344
type: Species
is: Q8N0X4
boundary condition: true
is: SBO:0000252
name: CLYBL
initial amount: NaN
is encoded by: hsa:171425
constant: false
initial concentration: NaN
has only substance units: false

metaR r0732
reversible: false
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110050#

metaR NACHEXA5ly
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110050#
reversible: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR THYMDt1
fast: false
reversible: false
name: thymd transport
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:9693094 NOTES:TDV
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

metaM his L c
is: CHEBI:15971
initial amount: NaN
initial concentration: 1.0
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: L-histidine
boundary condition: false

metaR EX aflatoxin LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: aflatoxin B1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_756a2e93_e1ff_4eab_a93f_eac40f0e2333
has only substance units: false
initial amount: NaN
is encoded by: hsa:10380
constant: false
is: O95861
name: BPNT1
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r0731
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
is described by: ECO:0000000
reversible: false

metaR ARAB Lt
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
reversible: true
name: L-arabinoase extracellular transport
reactant: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
fast: false

metaR r0389
reactant: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12

http://identifiers.org/biomodels.db/MODEL1310110050#_61025cdc_075f_4f66_aebb_4acf1bc1594c
name: HK1
initial amount: NaN
has only substance units: false
constant: false
is: B3KXY9
is encoded by: hsa:3098
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM lys L c
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
name: L-lysinium(1+)
has only substance units: false
is: CHEBI:32551
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00182
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_7e2157f0_c0d5_4943_a8f4_bac71621401b
is encoded by: hsa:4831
initial amount: NaN
is: P22392
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: NME2

metaR P450SCC1m
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: cholesterol monooxygenase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
product: MODEL1310110050#

metaM memgacpail hs r
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
constant: false
initial amount: NaN
is: CHEBI:15809
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_3698e009_655f_4353_a550_a736ca3d17a8
has only substance units: false
is: SBO:0000252
name: FAH
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: P16930
is encoded by: hsa:2184

metaR CHOLATEt
name: cholate transport via bicarbonate countertransport
modifier: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110050#
fast: false

metaR r0388
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110050#
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
product: MODEL1310110050#

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR r0734
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110050#
fast: false

metaR LINKDEG4ly
product: MODEL1310110050#
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110050#
name: degradation of proteoglycan linkage region, lysosomal
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaR 3MOX4HOXPGALDOX
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000304
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
fast: false

metaR S4TASE5ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_033f2a31_052a_4d5f_84c4_919b678b0619
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AL050025
type: Species
name: _AL050025_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_d774227b_3815_4509_8637_71fc9d9faa36
is: P47895
type: Species
has only substance units: false
name: ALDH1A3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:220
constant: false
initial concentration: NaN
initial amount: NaN

metaM fad c
boundary condition: false
is: CHEBI:16238
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
has only substance units: false
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
is: C00016
initial amount: NaN
initial concentration: 1.0
is: HMDB01248

metaM glyc3p m
boundary condition: false
is: HMDB00126
is: CHEBI:57597
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
name: Glycerol 3-phosphate
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00093
initial amount: NaN

metaR FAOXC180
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
kinetic law: MODEL1310110050#
reversible: false
product: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
fast: false
reactant: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction

metaR r0733
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reversible: false
modifier: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
type: Reaction
reactant: MODEL1310110050#

metaR r2330
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110050#

metaM f6p c
name: D-Fructose 6-phosphate
initial concentration: 1.0
type: Species
constant: false
is: C00085
is: SBO:0000247
boundary condition: false
is: HMDB00124
has only substance units: false
is: CHEBI:57579
is: http://identifiers.org/pubchem.compound/3385
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_cebdc3e3_2555_4eac_8fe6_6f37b9d28800
is: SBO:0000252
boundary condition: true
type: Species
is: Q9NY65
is encoded by: hsa:1962
initial amount: NaN
initial concentration: NaN
constant: false
name: EHHADH
has only substance units: false

metaM L2aadp m
is: CHEBI:58672
boundary condition: false
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false
name: L-2-aminoadipate(1-)
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaM so4 c
has only substance units: false
name: sulfate
type: Species
initial amount: NaN
is: CHEBI:16189
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: HMDB01448
is: SBO:0000247
constant: false

metaM ditp c
type: Species
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: dITP(4-)
is: HMDB03537
boundary condition: false
has only substance units: false

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_323ef87a_ad19_4955_8fc3_b0c771092867
is: SBO:0000252
name: PDE4A
type: Species
initial concentration: NaN
is encoded by: hsa:5141
initial amount: NaN
has only substance units: false
is: P27815
boundary condition: true
constant: false

metaR DOLPMT1 Ler
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110050#
reversible: false
is: SBO:0000176
modifier: MODEL1310110050#
fast: false
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.258

metaR r2331
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110050#

metaM alaala c
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12N2O3 CHARGE: 0
name: D-Alanyl-D-alanine
type: Species
is: HMDB00725

http://identifiers.org/biomodels.db/MODEL1310110050#_31f190b3_1643_4770_a673_e588fd3697b3
is encoded by: hsa:4967
initial concentration: NaN
has part: P09622
has only substance units: false
is encoded by: hsa:1743
initial amount: NaN
is encoded by: hsa:1738
type: Species
boundary condition: true
has part: O00330
constant: false
has part: Q02218
is: SBO:0000297
is encoded by: hsa:8050
has part: P36957
name: DLD:DLST:OGDH:PDHX

metaM ksi pre15 g
is: CHEBI:2504
has only substance units: false
initial amount: NaN
is: HMDB06552
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 15
notes: FORMULA: C149H240N10O119S4X CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110050#_7e4c55fb_cfd0_4718_bf61_47a9b05962ed
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54
is: P13686
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
name: ACP5

http://identifiers.org/biomodels.db/MODEL1310110050#_23514bd5_1adc_45ec_9583_ef98c4e48f3b
initial concentration: NaN
has only substance units: false
name: ACAA2
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10449
is: P42765
constant: false
initial amount: NaN

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR r2199
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110050#
is: SBO:0000185

metaM hyptaur c
is: HMDB00965
is: CHEBI:16668
boundary condition: false
has only substance units: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Hypotaurine
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_b43ae0d9_4c5e_481b_9fbc_27e1df0d8173
has only substance units: false
is: Q9ULD0
initial amount: NaN
name: OGDHL
type: Species
constant: false
boundary condition: true
is encoded by: hsa:55753
initial concentration: NaN
is: SBO:0000252

metaM hs deg9 l
name: heparan sulfate, degradation product 9
is: CHEBI:18268
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: HMDB06355
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_56db7a1b_f4a6_4096_8fba_c3749ac1800d
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54898
type: Species
initial amount: NaN
is: Q9NXB9
has only substance units: false
constant: false
name: ELOVL2

metaR KHte
is: SBO:0000185
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000134
kinetic law: MODEL1310110050#
fast: false
reversible: true
name: KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110050#

metaM ha deg1 l
name: hyaluronan degradation product 1
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C22H33N2O16 CHARGE: -1
boundary condition: false
is: SBO:0000247
is: CHEBI:16336
initial amount: NaN
type: Species
constant: false

metaM HC02175 e
has only substance units: false
is: CHEBI:27689
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
name: caprate
initial concentration: 1.0
constant: false

metaR DOLPGT3 Ler
notes: GENE_ASSOCIATION: (84920.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is version of: http://identifiers.org/ec-code/2.4.1.256
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reversible: false
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_022a0596_22f4_46d5_ba32_ffd94165e512
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:5313
is: P30613
initial concentration: NaN
boundary condition: true
name: PKLR
is: SBO:0000252

metaR r2332
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110050#

metaR r0735
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_c5650bc8_e1e5_4a6c_bd62_a56674fa256e
is encoded by: hsa:125
constant: false
is: P00325
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ADH1B
type: Species
initial amount: NaN
boundary condition: true

metaM gtp n
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
constant: false
name: GTP(4-)
initial amount: NaN
has only substance units: false
is: HMDB01273

metaM Ser Thr l
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: XH CHARGE: 0
type: Species
is: SBO:0000247
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
is: HMDB06254

http://identifiers.org/biomodels.db/MODEL1310110050#_fe3f9b25_f7d2_4afe_a056_be177e099928
constant: false
is: P57054
initial amount: NaN
name: PIGP
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:51227
type: Species
initial concentration: NaN

metaM ddeccrn e
initial amount: NaN
is: HMDB02250
boundary condition: false
has only substance units: false
notes: FORMULA: C19H37NO4 CHARGE: 0
name: lauroyl carnitine
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_4edc32c5_7bc9_4d85_8694_0cc16f4b56b1
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AA203143
name: _AA203143_1_c

http://identifiers.org/biomodels.db/MODEL1310110050#_b3a579ea_29b3_4513_9f75_20974b114a6f
name: ALG3
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:10195
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaM gmp c
is: SBO:0000247
is: HMDB01397
boundary condition: false
is: C00144
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115
type: Species
constant: false
initial amount: NaN
name: GMP
initial concentration: 1.0
has only substance units: false

metaR r2197
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false

metaM so4 e
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
name: sulfate
is: CHEBI:16189
initial amount: NaN
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110050#_25d37ec8_7753_48db_8498_dee586b804da
is: Q9BX95
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:81537
name: SGPP1
is: SBO:0000252
boundary condition: true

metaM pchol hs e
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: Phosphatidylcholine
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial amount: NaN
is: CHEBI:16110

metaR r2333
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000

metaR r0512
kinetic law: MODEL1310110050#
type: Reaction
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM gtp m
is: HMDB01273
is: CHEBI:37565
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
name: GTP
initial concentration: 1.0
is: C00044
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_2c5cbcd5_68fa_4aad_8097_3abdf787c7ba
type: Species
has only substance units: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN
is encoded by: hsa:513
initial amount: NaN
constant: false
is encoded by: hsa:514
is: SBO:0000297
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_2c942947_daa9_41ad_9fb9_a4fdb13b913e
is encoded by: hsa:11041
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: O43505
name: B3GNT1
initial amount: NaN

metaM pchol hs c
boundary condition: false
has only substance units: false
name: Phosphatidylcholine
initial concentration: 1.0
is: CHEBI:16110
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN

metaR r2334
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110050#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_69d3cabd_214b_4d22_af46_fd2db5be19e8
initial amount: NaN
is encoded by: hsa:1543
has only substance units: false
is: A0N0X8
is: SBO:0000252
name: CYP1A1
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaM methf c
is: CHEBI:57455
is: C00445
name: 5,10-Methenyltetrahydrofolate
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01354
type: Species
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0

metaR 3DSPHR
reactant: MODEL1310110050#
type: Reaction
fast: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.102
product: MODEL1310110050#
is described by: ECO:0000269
name: 3-Dehydrosphinganine reductase
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
reversible: false

metaM 3uib c
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
name: 3-Ureidoisobutyrate
is: HMDB02031
boundary condition: false
initial concentration: 1.0
is: CHEBI:1670
initial amount: NaN

metaR r2198
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
is: SBO:0000185

metaR r1487
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_b888f376_7d4b_455c_98b2_46b87a2573c2
name: TPK1
type: Species
is: F5GZG6
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:27010
is: SBO:0000252
constant: false

metaR CSNAT2x
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
modifier: MODEL1310110050#

metaR r1548
is described by: ECO:0000000
product: MODEL1310110050#
is: SBO:0000185
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2338
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
is described by: ECO:0000000

metaR AKR1D
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.1.3
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_73c5f8f2_076a_49a9_a580_0ce7cd89ecd7
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: SLC27A2
initial concentration: NaN
is encoded by: hsa:11001
is: O14975
is: SBO:0000252
type: Species

metaM cs b deg2 l
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00812
notes: FORMULA: C37H54NO41S3 CHARGE: -5
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: CHEBI:16953
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_17ca2795_4827_4cb7_bced_11b129c94bdc
boundary condition: true
type: Species
name: IK
is: Q13123
is encoded by: hsa:3550
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaR GLUPRT
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reversible: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.2.14
name: glutamine phosphoribosyldiphosphate amidotransferase

metaR r0504
is version of: http://identifiers.org/ec-code/2.3.3.10
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
type: Reaction
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
fast: false

metaR RE1845C
fast: false
product: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
name: RE1845
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000

metaM xoltetrol m
initial concentration: 1.0
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: HMDB01231
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17278
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_873f2ebb_a3a0_4068_9c27_081f89317eb4
is encoded by: hsa:10476
name: ATP5H
boundary condition: true
has only substance units: false
is: O75947
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_54850d99_2990_4859_a419_739d18b9b61b
type: Species
is: B2R6S5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51727
name: CMPK1
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR r1547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
is described by: ECO:0000000

metaM Ser Thr g
notes: FORMULA: XH CHARGE: 0
type: Species
initial amount: NaN
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
boundary condition: false
is: HMDB00645
initial concentration: 1.0
is: CHEBI:58336
is: SBO:0000247

metaM acald c
name: acetaldehyde
boundary condition: false
has only substance units: false
is: HMDB00990
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
is: CHEBI:15343
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_2ba99b8a_3642_410e_bc24_3d7618b9af84
constant: false
is: P49441
type: Species
is encoded by: hsa:3628
is: SBO:0000252
boundary condition: true
name: INPP1
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR D 3AIBt
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110050#
name: D-3-amino-isobutyrate transport
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110050#
fast: false

metaM adrncoa m
name: adrenyl coenzyme A
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
type: Species
is: SBO:0000247
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0

metaM hexdicoa c
constant: false
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247
initial amount: NaN
is: HMDB02014
boundary condition: false
name: hexadecanedioylcoa
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_13f5e40a_a207_42b7_a623_0de755c4beb1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P60891
constant: false
has only substance units: false
name: PRPS1
initial amount: NaN
is encoded by: hsa:5631
type: Species

metaR DURIPP
is version of: http://identifiers.org/ec-code/2.4.2.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
fast: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: deoxyuridine phosphorylase
reactant: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
reversible: true
type: Reaction
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_e096a5b5_0c3a_4285_bd78_0877fbc13b9b
initial concentration: NaN
name: GGH
has only substance units: false
boundary condition: true
is encoded by: hsa:8836
initial amount: NaN
constant: false
is: Q92820
is: SBO:0000252
type: Species

metaR ASCBOX
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
is described by: ECO:0000000
name: ascorbic acid oxidase

metaM acnacngalgbside hs c
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: disialyl galactosylgloboside
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: C00036
is: HMDB00223
is: CHEBI:3338

metaR r1546
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
type: Reaction

metaR ADSK
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
name: adenylyl-sulfate kinase
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110050#
is described by: ECO:0000269
reversible: false

metaR G14T6g
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110050#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110050#

metaR r1148
is: SBO:0000185
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000000
reversible: true
name: Active transport

metaM pram c
is: CHEBI:58681
is: C03090
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01128
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
name: 5-Phospho-beta-D-ribosylamine
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR 5MTHFt2
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES:IT
is: SBO:0000185
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000269
modifier: MODEL1310110050#
product: MODEL1310110050#
reversible: true
fast: false
reactant: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_5ce98708_e337_4a45_940c_aa6c7afa8d14
name: CHST6
initial concentration: NaN
is: SBO:0000252
is: Q9GZX3
constant: false
initial amount: NaN
is encoded by: hsa:4166
has only substance units: false
type: Species
boundary condition: true

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR r0502
fast: false
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
modifier: MODEL1310110050#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_4199eba3_ce44_4e70_9534_fe47b31d972c
type: Species
boundary condition: true
is: P17568
is encoded by: hsa:4713
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFB7
initial amount: NaN
is: SBO:0000252

metaR CRNtx
reversible: true
is: SBO:0000185
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
name: carnitine transport peroxisome to mitochondria
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_855df0a9_d7a9_4c22_b085_5580ff8b76e1
is encoded by: hsa:4830
boundary condition: true
type: Species
is: SBO:0000252
name: NME1
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaM adn c
is: CHEBI:16335
boundary condition: false
is: HMDB00050
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
has only substance units: false
is: C00212
type: Species
initial amount: NaN
initial concentration: 1.0
name: Adenosine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_354416e5_5c01_409e_aa72_bf3ec7b1475d
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10165
initial amount: NaN
name: SLC25A13
constant: false
boundary condition: true
is: SBO:0000252
is: Q9UJS0

metaR r1147
product: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000000
fast: false

metaR ADRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
name: fatty acid transport via diffusion
type: Reaction
fast: false

metaR PI45PLC
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
product: MODEL1310110050#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
fast: false

metaR r2017
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
modifier: MODEL1310110050#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
type: Reaction
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_8589dfa2_e3ae_4b32_b472_39e30c9214b0
initial concentration: NaN
type: Species
is: P17516
is: SBO:0000252
has only substance units: false
boundary condition: true
name: AKR1C4
constant: false
initial amount: NaN
is encoded by: hsa:1109

metaR C51CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaM nrpphrsf c
has only substance units: false
is: SBO:0000247
is: HMDB02062
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
name: Sulfate derivative of norepinephrine
type: Species
is: http://identifiers.org/pubchem.compound/123747

http://identifiers.org/biomodels.db/MODEL1310110050#_60960741_2b99_4138_a5de_b479499c804f
type: Species
is: SBO:0000252
name: AHCYL1
is encoded by: hsa:10768
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR FRDPtcr
is: SBO:0000185
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
fast: false
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.

metaR PAPStg
kinetic law: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
product: MODEL1310110050#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110050#
name: 3'-Phosphoadenylyl sufate Golgi transport

metaR MI1P Dtn
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
name: inositol 1-phosphate nuclear transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110050#_6cdebec2_df30_4b3f_8c44_b83c69b9bc74
initial concentration: NaN
is encoded by: hsa:9962
boundary condition: true
name: SLC23A2
is: SBO:0000252
has only substance units: false
is: Q9UGH3
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_05314260_3e26_4473_b3a1_debe3d166821
is encoded by: hsa:53947
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: A4GALT
initial concentration: NaN
is: SBO:0000252
is: Q9NPC4
boundary condition: true

metaM CE2420 m
has only substance units: false
is: SBO:0000247
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
type: Species
initial amount: NaN
is: CHEBI:28387
constant: false
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110050#_25551817_588f_4c23_8f46_a66917ea56c7
constant: false
name: CHKA
has only substance units: false
is encoded by: hsa:1119
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR RE0830N
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
fast: false
product: MODEL1310110050#
name: RE0830
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110050#

metaR r0170
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_ce0d6379_e814_4b94_9bbe_448ce1a607fe
constant: false
is: P14854
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1340
initial amount: NaN
name: COX6B1

metaM acnam c
initial amount: NaN
is: CHEBI:35418
initial concentration: 1.0
is: HMDB00230
constant: false
type: Species
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate
boundary condition: false
is: SBO:0000247

metaR PGI
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is version of: http://identifiers.org/ec-code/5.3.1.9
product: MODEL1310110050#
name: glucose-6-phosphate isomerase
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110050#_e24f55b6_3c26_4350_a143_69c18911325f
initial amount: NaN
name: FLAD1
constant: false
boundary condition: true
type: Species
is encoded by: hsa:80308
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q8NFF5

metaR F1Atg
fast: false
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000185
name: F1alpha transport (from golgi to lysosome)
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_5f0450e7_5f19_4661_bc8e_96133dcedf53
initial amount: NaN
type: Species
is: Q9Y2D0
has only substance units: false
is encoded by: hsa:11238
constant: false
is: SBO:0000252
initial concentration: NaN
name: CA5B
boundary condition: true

metaM ksi pre29 g
is: CHEBI:28067
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
initial amount: NaN
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 29
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaM chol c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
type: Species
constant: false
is: HMDB00097
is: C00114
initial amount: NaN
name: Choline
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_83436206_df0e_41a5_8264_0e890a59959f
type: Species
constant: false
is: P04183
initial amount: NaN
has only substance units: false
is encoded by: hsa:7083
initial concentration: NaN
is: SBO:0000252
name: TK1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_2c020659_f523_49f1_96a4_017f44eb0f92
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:4722
constant: false
boundary condition: true
name: NDUFS3
is: SBO:0000252
is: O75489
initial concentration: NaN

metaM HC00342 m
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
is: CHEBI:16383
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_9d04df07_4bdc_47ec_a389_9076f5f4f377
is: B7Z6M3
type: Species
constant: false
has only substance units: false
name: DGKZ
is: SBO:0000252
is encoded by: hsa:8525
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r2018
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: false
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000185
modifier: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EHGLATm
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000212
is: SBO:0000176
reactant: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
type: Reaction
modifier: MODEL1310110050#
product: MODEL1310110050#

metaR r1549
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#

metaR ALAtN1
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110050#
is described by: ECO:0000269
name: Alanine transport (Na, H coupled)
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_4deac128_69f6_49cb_8696_b1bac27a9132
is: P07686
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3074
boundary condition: true
name: HEXB
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_76dd7ba8_ed01_4bc7_8f20_7d9ecdcd19c0
name: PEMT
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10400

http://identifiers.org/biomodels.db/MODEL1310110050#_4ffb07b4_36aa_47ee_8fb3_5523f701f8ab
name: SLC25A2
is: Q9BXI2
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:83884
boundary condition: true
initial amount: NaN

metaR LPASE
reactant: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
type: Reaction
fast: false
name: lysophospholipase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
is version of: http://identifiers.org/ec-code/3.1.1.5
is: SBO:0000176

metaR ST3GAL21g
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110050#
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
is described by: ECO:0000269
fast: false

metaR METS
reversible: false
product: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.1.1.13
is described by: ECO:0000134
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
name: methionine synthase
fast: false
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y

metaR r0173
is version of: http://identifiers.org/ec-code/3.6.1.19
is: SBO:0000176
reactant: MODEL1310110050#
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
product: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000000

metaM ditp n
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB03537
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
is: CHEBI:61382

metaR r1540
product: MODEL1310110050#
modifier: MODEL1310110050#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
reversible: false

metaM ksi pre16 g
has only substance units: false
constant: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: HMDB06552
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 16
type: Species
is: CHEBI:2504
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_122d0cbf_0678_472d_8788_73cece330bd5
initial amount: NaN
type: Species
initial concentration: NaN
is: O00443
boundary condition: true
name: PIK3C2A
constant: false
is: SBO:0000252
is encoded by: hsa:5286
has only substance units: false

metaM dgdp n
initial concentration: 1.0
name: dGDP(2-)
is: CHEBI:58595
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
initial amount: NaN
type: Species
is: HMDB00960

metaR DGAT
name: diacylglycerol acyltransferase
reactant: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.20
product: MODEL1310110050#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is described by: ECO:0000000

metaM fe3 e
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
name: Fe3+
initial amount: NaN
is: HMDB12943
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:29034
type: Species
is: SBO:0000247

metaM lpchol hs c
is: CHEBI:60479
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: lysophosphatidylcholine
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

metaR GPIAT
product: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: glucosaminylphosphatidyl inositol acetyltransferase
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
reactant: MODEL1310110050#
reversible: false
fast: false
type: Reaction

metaR GGH 10FTHF5GLUe
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110050#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110050#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110050#

metaM dha e
name: glycerone
has only substance units: false
is: HMDB01882
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
constant: false
type: Species
initial amount: NaN
is: CHEBI:16016
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_0dfad633_7ae8_4b47_872b_0412d8e7b041
is encoded by: hsa:100128062
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: _100128062_1_m
initial concentration: NaN
boundary condition: true
constant: false

metaR CYTK12n
type: Reaction
modifier: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110050#
name: cytidylate kinase (dCMP,dCTP),nuclear
fast: false
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000176

metaR GP1CALPHAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: gp1calpha hs transport
is: SBO:0000185
product: MODEL1310110050#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_5a55c4c0_66df_47d1_83ca_a546dd6b9204
is: Q16678
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1545
type: Species
name: CYP1B1
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaM m6mpdol L r
is: SBO:0000247
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
is: CHEBI:37635
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_85737bbe_02e4_40f5_9169_3e754ccbd381
boundary condition: true
is encoded by: hsa:5213
type: Species
initial amount: NaN
has part: P08237
has only substance units: false
constant: false
is: SBO:0000297
initial concentration: NaN
name: PFKM:PFKP

metaM HC01610 e
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
is: CHEBI:28607
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: CoproporphyrinogenI
constant: false
is: SBO:0000247
type: Species

metaR CDSm
name: phosphatidate cytidylyltransferase
type: Reaction
modifier: MODEL1310110050#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.41
kinetic law: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
reversible: false
reactant: MODEL1310110050#
is: SBO:0000176

metaR ALADGLYexR
kinetic law: MODEL1310110050#
name: D-alanine/glycine reversible exchange
reactant: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000304
fast: false
is: SBO:0000185

metaR GCHOLAte
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110050#
reversible: true
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_0db3f5f0_819c_45a8_9815_57b53857fc10
initial amount: NaN
constant: false
is encoded by: hsa:217
type: Species
has only substance units: false
is: P05091
name: ALDH2
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_b7155fc5_afef_4400_9cad_6268ea6adc43
initial amount: NaN
type: Species
name: _BE966236_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:BE966236
constant: false
boundary condition: true

metaM 3aib D m
name: D-3-Amino-isobutanoate
is: HMDB02299
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: C03265
has only substance units: false

metaM nrpphrsf e
name: Sulfate derivative of norepinephrine
boundary condition: false
has only substance units: false
is: HMDB02062
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: http://identifiers.org/pubchem.compound/123747
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaR H2Otly
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
type: Reaction

metaM cspg c e
initial amount: NaN
initial concentration: 1.0
is: HMDB00300
is: C00106
type: Species
boundary condition: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:17568
notes: FORMULA: C45H66N2O45S3X CHARGE: -5

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM fe3 c
is: HMDB12943
constant: false
notes: FORMULA: Fe CHARGE: 3
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Fe3+

metaM lpchol hs e
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: CHEBI:60479
boundary condition: false
initial amount: NaN
name: lysophosphatidylcholine
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM cs e deg7 l
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15936
initial amount: NaN
notes: FORMULA: C23H35O27S2 CHARGE: -3
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_d5c49df1_a5d7_4896_8a1d_8f638f685fdb
is encoded by: hsa:1103
is: P28329
name: CHAT
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaM lnlccoa m
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
has only substance units: false
is: HMDB01064
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983

http://identifiers.org/biomodels.db/MODEL1310110050#_d04e717f_1d61_47f5_b232_2415193edf0c
name: SUCLG2
is encoded by: hsa:8801
constant: false
is: Q96I99
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM c51crn e
is: SBO:0000247
initial concentration: 1.0
name: tiglyl carnitine
type: Species
notes: FORMULA: C12H21NO4 CHARGE: 0
is: HMDB02366
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaM dgdp m
is: CHEBI:58595
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)
has only substance units: false
is: SBO:0000247
is: HMDB00960
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_ffee8df0_01b5_4a93_8fe0_4301e174e879
type: Species
is encoded by: hsa:5805
name: PTS
is: Q03393
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaR GP1CALPHAtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110050#
is described by: ECO:0000000
name: gp1calpha hs intracellular transport
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_7d579d24_4868_4add_a5cc_b45bc7820d64
is encoded by: hsa:5294
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P48736
type: Species
name: PIK3CG
has only substance units: false
initial concentration: NaN
constant: false

metaM e4p c
initial amount: NaN
is: C00279
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16897
boundary condition: false
is: HMDB01321
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
constant: false
is: SBO:0000247
name: D-Erythrose 4-phosphate

http://identifiers.org/biomodels.db/MODEL1310110050#_e4331704_80c0_47e0_b73e_37062649381d
initial concentration: NaN
has only substance units: false
constant: false
is: Q9P212
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PLCE1
type: Species
is encoded by: hsa:51196

http://identifiers.org/biomodels.db/MODEL1310110050#_a08893df_07b7_4678_b619_7c0bb4e353fe
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: Q9HC21
initial amount: NaN
constant: false
name: SLC25A19
is encoded by: hsa:60386
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_7e69afe5_aff7_48e3_8f5a_1de49fe6e21e
has only substance units: false
boundary condition: true
name: CYP2D6
type: Species
is encoded by: hsa:1565
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q6NXU8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_473e3755_b5ba_41e3_a158_bda887a59d62
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:515
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_ac9e3a6f_3717_488e_8ec5_ea593fd148b7
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6901
name: TAZ
initial amount: NaN
is: Q16635
type: Species

metaR r2447
is: SBO:0000185
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: false
name: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.3
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110050#

metaR r1544
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM arachcoa m
initial concentration: 1.0
is: HMDB04258
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: arachidyl coenzyme A
type: Species
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR MAN6PI
name: mannose-6-phosphate isomerase
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_50e7965d_7589_4973_b2cf_c788995c533d
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27034
initial amount: NaN
has only substance units: false
name: ACAD8
constant: false
initial concentration: NaN
type: Species
is: Q6ZWP6

metaR CSNAT2m
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
name: carnitine O-aceyltransferase, mitochondrial
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
type: Reaction
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110050#

metaR DNDPt23m
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dGTP antiport
is: SBO:0000185
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110050#

metaM adn e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
initial concentration: 1.0
type: Species
name: Adenosine
boundary condition: false
is: C00212
is: HMDB00050
constant: false
is: CHEBI:16335

metaM core2 g
has only substance units: false
type: Species
is: CHEBI:15876
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Core 2
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false

metaM thmtp c
name: thiamine(1+) triphosphate(4-)
constant: false
is: HMDB01512
is: CHEBI:58938
is: SBO:0000247
notes: FORMULA: C12H16N4O10P3S CHARGE: -3 INCHI: InChI=1S/C12H19N4O10P3S/c1-8-11(30-7-16(8)6-10-5-14-9(2)15-12(10)13)3-4-24-28(20,21)26-29(22,23)25-27(17,18)19/h5,7H,3-4,6H2,1-2H3,(H5-,13,14,15,17,18,19,20,21,22,23)/p-3 EHMN_ABBREVIATION: C03028
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_aacdfa9d_07ac_43f6_8c0a_8c330df0a31c
type: Species
boundary condition: true
is encoded by: hsa:80724
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ACAD10
initial amount: NaN
constant: false
is: G3XAJ0

metaR ADSS
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: adenylosuccinate synthase
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is described by: ECO:0000134
type: Reaction
reversible: false
reactant: MODEL1310110050#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.4
modifier: MODEL1310110050#

metaR r0178
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.21
type: Reaction
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
reversible: true
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaM cspg c l
initial amount: NaN
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB02183
has only substance units: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:36005

metaR NACHEX3ly
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaR HISyLATthc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_7b7fe7b7_08bc_478b_824c_2060dd9842ef
type: Species
initial concentration: NaN
name: ABAT
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:18

metaR B3GNT39g
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
reversible: false
reactant: MODEL1310110050#
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR GLCURtly
name: glucuronate transport into lysososme
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_406906f5_aadc_441c_b28f_8708d0ddbeec
initial amount: NaN
is: P41440
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: SLC19A1
constant: false
is encoded by: hsa:6573
boundary condition: true

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM CE5854 e
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
has only substance units: false
initial amount: NaN
name: gama-CEHC-glucuronide
is: HMDB02710
is: CHEBI:27485
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_befa39ef_ef25_4303_8bae_5c2a0f673cd1
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CPOX
is: P36551
is encoded by: hsa:1371
constant: false
type: Species

metaM apoC Lys btn c
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial concentration: 1.0
is: CHEBI:32551
boundary condition: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial amount: NaN
is: HMDB00182

metaM CE2432 m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57795
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false
is: SBO:0000247
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110050#_87404579_a7e1_4500_9633_876197085fb4
is encoded by: hsa:9123
type: Species
name: SLC16A3
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O15427
constant: false
is: SBO:0000252

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR r0179
reactant: MODEL1310110050#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110050#
reversible: true
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaM btamp m
constant: false
is: HMDB04220
has only substance units: false
initial amount: NaN
is: CHEBI:3110
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Biotinyl-5'-AMP

metaR PTE3x
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110050#
name: peroxisomal acyl-CoA thioesterase
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
modifier: MODEL1310110050#
fast: false

metaR IVCRNe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR MECOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
is described by: ECO:0000212

metaM xu5p D c
is: CHEBI:57737
boundary condition: false
has only substance units: false
constant: false
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: D-xylulose 5-phosphate(2-)
is: HMDB00868

metaM adrncoa c
boundary condition: false
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
name: adrenyl coenzyme A
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
initial amount: NaN
constant: false
initial concentration: 1.0

metaM glyc R m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16659
constant: false
initial amount: NaN
name: D-glycerate
type: Species
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: HMDB00139
boundary condition: false
has only substance units: false

metaM cit c
type: Species
constant: false
boundary condition: false
name: Citrate
is: C00158
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16947
has only substance units: false
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaM thmtp e
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01512
is: SBO:0000247
name: thiamine(1+) triphosphate(4-)
is: CHEBI:58938
initial amount: NaN
notes: FORMULA: C12H16N4O10P3S CHARGE: -3 INCHI: InChI=1S/C12H19N4O10P3S/c1-8-11(30-7-16(8)6-10-5-14-9(2)15-12(10)13)3-4-24-28(20,21)26-29(22,23)25-27(17,18)19/h5,7H,3-4,6H2,1-2H3,(H5-,13,14,15,17,18,19,20,21,22,23)/p-3 EHMN_ABBREVIATION: C03028
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_90bb13cd_84b3_48d8_afce_6f4d4126e40f
is: SBO:0000252
type: Species
is: Q5T4W8
constant: false
initial amount: NaN
initial concentration: NaN
name: ST3GAL3
is encoded by: hsa:6487
boundary condition: true
has only substance units: false

metaR XOLTRIOLtm
reactant: MODEL1310110050#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
name: lipid, flip-flop intracellular transport

metaM acald e
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
boundary condition: false
is: CHEBI:15343
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00990
constant: false

metaR UMPK5n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110050#
name: UMP kinase (dATP),nuclear
is: SBO:0000176
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269

metaR SUBEACTD
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_f1e7b313_85eb_40b0_ad7b_ba558e62f1ac
name: SLC5A10
is: A0PJK1
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:125206
type: Species
initial concentration: NaN

metaR CHOLESACATc
is version of: http://identifiers.org/ec-code/2.3.1.26
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110050#
name: esterification of cholesterol to cholesterol ester within enterocytes
notes: GENE_ASSOCIATION: (8435.1) or (6646.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 143-144. charasuraisin, c. in short dissertation 19 (2008) NOTES:re-formation of cholesterol ester within enterocytes, then exit in chylomicrons into the lymph.

metaR GLYBt4 2 r
is: SBO:0000185
name: Betaine transport (sodium symport) (2:1)
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true

metaM cit e
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
type: Species
is: SBO:0000247
constant: false
name: citrate(3-)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00094

metaR CYTK5n
reversible: true
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
product: MODEL1310110050#
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_f77d49b6_f134_436c_815c_33bc461f7ff7
constant: false
has part: Q6NZ59
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000297
type: Species
is encoded by: hsa:522
boundary condition: true

metaR LYStn
reactant: MODEL1310110050#
name: L-lysine transport, nuclear
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110050#_854e3383_f51d_43f1_8706_9f0c923fcd8a
boundary condition: true
name: ACAD9
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q9H845
is encoded by: hsa:28976
initial amount: NaN

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM ribflv e
constant: false
is: CHEBI:3554
type: Species
is: SBO:0000247
initial amount: NaN
name: Riboflavin
is: C00255
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: HMDB00244

metaM lnlccoa c
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247
initial concentration: 1.0
type: Species
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
has only substance units: false
is: HMDB01064
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_e79a9c2b_937d_4902_9ecb_666983c23894
type: Species
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial amount: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:509
initial concentration: NaN
has part: Q6I9V2
constant: false
boundary condition: true
is encoded by: hsa:498
has part: P25705

metaM cs c deg2 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
boundary condition: false
is: CHEBI:15748
is: HMDB00127
constant: false
is: SBO:0000247
type: Species

metaR GACPAILter
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
name: glucosaminyl-acylphosphatidylinositol ER flippase

http://identifiers.org/biomodels.db/MODEL1310110050#_ab6726c8_7156_4b5f_b75a_c169a59610d6
is: Q969I6
boundary condition: true
has only substance units: false
name: SLC38A4
is: SBO:0000252
type: Species
is encoded by: hsa:55089
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_b2f65975_1c4a_4931_98c1_e125aa539113
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: Q9UPR5
is encoded by: hsa:6543
name: SLC8A2
boundary condition: true
initial concentration: NaN

metaM ficytC m
is: SBO:0000247
name: Ferricytochrome c
is: CHEBI:15991
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r0728
is described by: ECO:0000000
product: MODEL1310110050#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
reversible: true

metaR ASNtN1
name: Asparagine transport (Na, H coupled)
type: Reaction
reversible: true
fast: false
product: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269

metaR RE0912C
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
type: Reaction
modifier: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (25830.1) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10199779,PMID:11397879,PMID:12039030,PMID:8767510,PMID:9463486 NOTES:
product: MODEL1310110050#
name: RE0912
reversible: false

metaM ksi pre33 g
type: Species
initial amount: NaN
is: HMDB06552
boundary condition: false
is: CHEBI:2504
constant: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 33
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
has only substance units: false
is: SBO:0000247

metaM udp r
has only substance units: false
is: C00015
name: UDP
boundary condition: false
is: HMDB00295
is: CHEBI:58223
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaR GLYtm
name: glycine passive transport to mitochondria
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
product: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
fast: false
type: Reaction

metaM ribflv c
is: HMDB00244
is: CHEBI:3554
constant: false
type: Species
name: Riboflavin
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00255
boundary condition: false

metaR r0729
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction

metaR DOPAtu
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
fast: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
is: SBO:0000185
name: Dopamine uniport
reversible: true

metaR 4ABUTtcn
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: transport of GABA
product: MODEL1310110050#

metaR r0727
fast: false
is described by: ECO:0000000
product: MODEL1310110050#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_bc1064bf_8e10_452e_944e_e022ff3c3198
type: Species
initial amount: NaN
is: P33121
constant: false
is encoded by: hsa:2180
name: ACSL1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR CSPG Atly
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: chondroitin sulfate A transport, extracellular to lysosome

http://identifiers.org/biomodels.db/MODEL1310110050#_7c0694e5_a116_4dde_9bf2_407e111f9a5c
is: SBO:0000252
name: ATP5A1
constant: false
is encoded by: hsa:498
has only substance units: false
boundary condition: true
initial concentration: NaN
is: B4DY56
type: Species
initial amount: NaN

metaR MG2er
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

metaR RE1531M
is: SBO:0000176
modifier: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
kinetic law: MODEL1310110050#
name: RE1531
type: Reaction

metaM dgdp c
is: C00361
is: CHEBI:58595
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
is: SBO:0000247
has only substance units: false
name: dGDP

http://identifiers.org/biomodels.db/MODEL1310110050#_b0794fb6_6f6d_4bb3_b69c_dc5440c4f001
constant: false
name: CYP27A1
is: SBO:0000252
is: Q02318
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1593
type: Species
has only substance units: false

metaM udp l
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
is: HMDB00295
constant: false
type: Species
name: UDP(3-)
is: CHEBI:58223
has only substance units: false

metaM xoltriol m
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: CHEBI:16496
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
has only substance units: false
is: HMDB01457

metaM dlnlcgcrn m
type: Species
boundary condition: false
name: dihomo-gamma-linolenyl carnitine
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
constant: false
is: HMDB01311
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:16004

metaR FAS80COA L
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
product: MODEL1310110050#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_df1c0711_3b8c_4cca_a247_8a996e3b341f
is encoded by: hsa:50484
initial concentration: NaN
name: RRM2B
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: Q7LG56
constant: false
initial amount: NaN

metaM decdicrn e
name: decadienoyl carnitine
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C17H29NO4 CHARGE: 0
is: HMDB13325
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_eb7f3bad_297f_4a23_b5cd_9255b3af3745
is: O00462
is: SBO:0000252
initial concentration: NaN
name: MANBA
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4126
has only substance units: false
constant: false

metaM fum m
constant: false
has only substance units: false
type: Species
is: C00122
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00134
is: CHEBI:29806

metaR MI4PP
kinetic law: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.3.25
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: false
name: myo-inositol 4-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110050#_a08ce773_f378_40e2_8d39_eb48cf540375
is encoded by: hsa:8050
name: PDHX
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: O00330
constant: false
is: SBO:0000252

metaM 3oddcoa x
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB03937
name: 3-Oxododecanoyl-CoA
initial amount: NaN
is: CHEBI:27868
constant: false
has only substance units: false

metaM c51crn c
notes: FORMULA: C12H21NO4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
name: tiglyl carnitine
initial amount: NaN
type: Species
constant: false
is: HMDB02366

metaR GLCNACASE4ly
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110050#
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: alpha-N-acetylglucosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110050#_41abb041_1e2b_489c_957e_bca3d4f9ce41
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3948
constant: false
name: LDHC
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_8932b176_c344_454b_abde_2ff2378534cb
is: SBO:0000252
is: Q9HC58
type: Species
is encoded by: hsa:57419
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC24A3
initial concentration: NaN

metaR A4GALTg
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000269
modifier: MODEL1310110050#
product: MODEL1310110050#
reversible: false
fast: false
type: Reaction
name: Lactosylceramide 4-alpha-galactosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.228
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_15f8cd9e_dfdb_482c_9a56_331f6fb6823a
constant: false
is: Q9UHV8
is encoded by: hsa:29124
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: LGALS13
boundary condition: true

metaR AG13T12g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110050#
fast: false

metaM 3odcoa x
is: SBO:0000247
initial concentration: 1.0
is: HMDB03939
is: CHEBI:28528
has only substance units: false
name: 3-Oxodecanoyl-CoA
boundary condition: false
type: Species
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial amount: NaN

metaM decdicrn c
is: HMDB13325
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C17H29NO4 CHARGE: 0
is: SBO:0000247
name: decadienoyl carnitine
constant: false
initial concentration: 1.0

metaM 10fthf7glu c
boundary condition: false
has only substance units: false
constant: false
name: 10-formyltetrahydrofolate-[Glu](7)
is: SBO:0000247
type: Species
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial concentration: 1.0
initial amount: NaN

metaR UDPG4E
name: UDPglucose 4-epimerase
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
modifier: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_1dd53a58_652c_4474_9a50_437be9c08833
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: PDE1A
is: Q9Y633
initial concentration: NaN
is encoded by: hsa:5136
is: SBO:0000252

metaR GLYtp
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
fast: false
product: MODEL1310110050#
name: glycine passive transport to peroxisome
reversible: true
is: SBO:0000185
reactant: MODEL1310110050#
is described by: ECO:0000000
type: Reaction

metaR PPBNGS
product: MODEL1310110050#
is described by: ECO:0000269
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
reversible: false
name: porphobilinogen synthase
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.24
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_96bbb8e5_e4e8_4a6b_a16f_41989d7327ca
is encoded by: hsa:8659
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ALDH4A1
is: P30038
type: Species
is: SBO:0000252
boundary condition: true

metaM udp n
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00295
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: CHEBI:58223
initial amount: NaN
name: UDP(3-)

metaM glyc m
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
is: C00116
is: CHEBI:17754
initial concentration: 1.0
name: Glycerol
type: Species
is: HMDB00131
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_164f755d_9f7e_41bf_82f0_5a374be61d58
constant: false
name: PLCD3
is encoded by: hsa:113026
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q8N3E9

metaM hexdicoa r
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: C08260
name: hexadecanedioylcoa
initial concentration: 1.0
is: HMDB00672

http://identifiers.org/biomodels.db/MODEL1310110050#_2a4520e4_40bc_4580_9cf4_4f232851c465
is encoded by: hsa:137872
initial concentration: NaN
name: ADHFE1
is: SBO:0000252
is: Q8IWW8
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_4e7a4b10_0bc8_457e_b31f_f60b6f2c1285
initial amount: NaN
has part: P05496
has part: P46459
is encoded by: hsa:4905
is encoded by: hsa:10476
initial concentration: NaN
has part: Q6IBB3
has part: P56385
is encoded by: hsa:9551
is encoded by: hsa:10632
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
constant: false
type: Species
is encoded by: hsa:521
has part: A0PJH2
is encoded by: hsa:515
is: SBO:0000297
has only substance units: false
has part: Q08ET0
is encoded by: hsa:522
has part: O75964
is encoded by: hsa:516

http://identifiers.org/biomodels.db/MODEL1310110050#_ba265e77_9d1f_498d_86b1_f2363fbf1b94
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23556
boundary condition: true
name: PIGN
constant: false

metaM icit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: HMDB00193
initial amount: NaN
is: C00311
type: Species
initial concentration: 1.0
name: Isocitrate
is: CHEBI:16087

http://identifiers.org/biomodels.db/MODEL1310110050#_1f94ad26_d7c6_485c_9b95_ab3528ac0667
name: DHODH
is encoded by: hsa:1723
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q02127
type: Species
constant: false

metaM arg L e
is: CHEBI:32682
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
has only substance units: false
name: L-argininium(1+)
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_b287726d_9969_41c5_b6c1_0aee8185271a
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM bhb m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: (R)-3-hydroxybutyrate
is: HMDB00011
is: CHEBI:10983
boundary condition: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
constant: false

metaM gd3 hs g
constant: false
name: GD3
is: CHEBI:28424
type: Species
has only substance units: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR DAG HSter
fast: false
reversible: false
name: diacylglycerol ER export
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000185
type: Reaction

metaM coumarin c
name: coumarin
is: CHEBI:28794
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H6O2 CHARGE: 0 INCHI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
has only substance units: false
boundary condition: false
is: HMDB01218
is: SBO:0000247
type: Species
constant: false

metaM amet m
type: Species
is: C00019
is: SBO:0000247
boundary condition: false
is: CHEBI:15414
constant: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
name: S-Adenosyl-L-methionine
is: HMDB01185
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_0ca29fbc_7c12_4d0c_933b_33f27797ae45
is: P54868
is encoded by: hsa:3158
boundary condition: true
has only substance units: false
initial concentration: NaN
name: HMGCS2
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaM 10fthf7glu e
initial concentration: 1.0
is: CHEBI:57454
type: Species
has only substance units: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
constant: false
name: 10-formyltetrahydrofolate-[Glu](7)
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00972

metaR ST3GAL22g
type: Reaction
kinetic law: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
product: MODEL1310110050#
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_d6e3a606_4320_4fff_94a4_8c5b48b01710
is: E5KSL6
is encoded by: hsa:1716
boundary condition: true
name: DGUOK
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_e712d98d_3804_4a18_9c4d_9ec754d9ce95
boundary condition: true
name: GALNT13
type: Species
constant: false
is: Q8IUC8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:114805

metaR HSD3A1r
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_534c35be_56f9_4c5b_b0ad_02bfe791d342
boundary condition: true
is: Q9NWU1
is encoded by: hsa:54995
constant: false
initial amount: NaN
has only substance units: false
name: OXSM
is: SBO:0000252
type: Species
initial concentration: NaN

metaM pail35p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: SBO:0000247
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
has only substance units: false
is: CHEBI:57923
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR r0722
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110050#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.3.12

http://identifiers.org/biomodels.db/MODEL1310110050#_f81e2d91_94a6_4595_8f2c_658816539f27
is encoded by: hsa:2746
name: GLUD1
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: E9KL48
constant: false

metaR r2341
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110050#
reversible: true
type: Reaction
fast: false

metaM gd1c hs e
boundary condition: false
is: SBO:0000247
is: HMDB00138
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: GD1c
type: Species
constant: false

metaM icit c
is: CHEBI:16087
constant: false
name: Isocitrate
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
is: HMDB00193
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM cit m
constant: false
boundary condition: false
is: HMDB00094
name: Citrate
has only substance units: false
is: CHEBI:16947
is: SBO:0000247
is: C00158
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species

metaM galgbside hs g
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
initial amount: NaN
constant: false
type: Species
is: CHEBI:28648
initial concentration: 1.0
name: galactosylgloboside
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR NTP3e
fast: false
type: Reaction
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110050#
reversible: false
modifier: MODEL1310110050#
is: SBO:0000176
name: nucleoside-triphosphatase (GTP)

http://identifiers.org/biomodels.db/MODEL1310110050#_68f73eb9_623e_44b2_91b0_d6700aaeda65
initial concentration: NaN
initial amount: NaN
is: Q6I9V2
constant: false
has only substance units: false
boundary condition: true
name: ATP5C1
is encoded by: hsa:509
is: SBO:0000252
type: Species

metaM n2m2masn g
is: C11530
has only substance units: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
initial amount: NaN
notes: FORMULA: C50H83N4O35X CHARGE: 0
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM amet c
name: S-Adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
constant: false
type: Species
is: HMDB01185
has only substance units: false
is: SBO:0000247
is: CHEBI:15414
initial concentration: 1.0
is: C00019
boundary condition: false

metaR FUMm
kinetic law: MODEL1310110050#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
reversible: true
name: fumarase, mitochondrial
fast: false
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#

metaM coumarin e
constant: false
is: HMDB01218
is: CHEBI:28794
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H6O2 CHARGE: 0 INCHI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: coumarin

http://identifiers.org/biomodels.db/MODEL1310110050#_bd997744_4358_486b_b089_9f4376b05fd0
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PLCG1
boundary condition: true
is: P19174
is encoded by: hsa:5335
type: Species
constant: false
is: SBO:0000252

metaM 3oddcoa m
initial concentration: 1.0
initial amount: NaN
is: HMDB03937
name: 3-Oxododecanoyl-CoA
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:27868
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_954d19e0_854c_43e6_a4f0_7df36fc8ea39
type: Species
name: SLC6A9
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6536
initial amount: NaN
is: P48067
has only substance units: false
boundary condition: true
constant: false

metaM ppbng c
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
is: HMDB00245
constant: false
has only substance units: false
is: CHEBI:58126
is: C00931
name: Porphobilinogen
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM apoC Lys btn m
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: C05552
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: HMDB03134

metaR r0721
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110050#
type: Reaction
is: SBO:0000176
fast: false

metaM arg L c
constant: false
is: HMDB00517
initial concentration: 1.0
type: Species
is: CHEBI:32682
name: L-argininium(1+)
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM udp g
is: HMDB00295
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
name: UDP(3-)
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58223
is: SBO:0000247

metaR r0399
modifier: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_38362c26_0814_4cab_a09b_b1c650aa6f39
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:83549
initial concentration: NaN
is: Q5JT09
constant: false
name: UCK1

metaM glypro c
name: Glycylproline
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/79101
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H12N2O3 CHARGE: 0
is: HMDB00721
is: SBO:0000247

metaM fgam c
is: HMDB01308
initial amount: NaN
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
boundary condition: false
is: C04376
is: CHEBI:58426
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376

http://identifiers.org/biomodels.db/MODEL1310110050#_3ebb9f6f_5840_4b7d_948f_654cdc2e6149
type: Species
is encoded by: hsa:376497
name: SLC27A1
initial amount: NaN
constant: false
is: Q6PCB7
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR FAOXC16080m
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is: SBO:0000176

metaM T antigen g
boundary condition: false
initial amount: NaN
has only substance units: false
name: T antigen (core 1)
type: Species
is: SBO:0000247
notes: FORMULA: C14H24NO10X CHARGE: 0
initial concentration: 1.0
is: CHEBI:22783
constant: false

metaM gd1c hs g
is: SBO:0000247
is: HMDB00138
is: CHEBI:58235
boundary condition: false
initial amount: NaN
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: GD1c

metaM pydx c
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: SBO:0000247
constant: false
name: Pyridoxal
is: CHEBI:17310
initial amount: NaN
is: C00250
initial concentration: 1.0
is: HMDB01545
has only substance units: false
type: Species
boundary condition: false

metaR BAAT4x
is described by: ECO:0000304
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
name: bile acid Coenzyme A: amino acid N-acyltransferase
reversible: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ

metaR SERGLNexR
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000185
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
name: L-Serine/Glutamine reversible exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_fc63ebf8_36d0_4269_ad79_f4ac23d0506e
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AU149534
constant: false
name: _AU149534_1_m

metaR UDPtl
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
product: MODEL1310110050#
name: udp intracellular transport
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction

metaR RPI
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110050#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.6
reversible: true
is described by: ECO:0000000
type: Reaction
name: ribose-5-phosphate isomerase
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaM ac c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
has only substance units: false
is: HMDB00042
is: SBO:0000247
initial amount: NaN
is: CHEBI:30089
type: Species
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110050#_64926e1a_2d84_4191_af8a_de2cf23dc93e
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: PIGX
is: Q8TBF5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54965

metaM glypro e
notes: FORMULA: C7H12N2O3 CHARGE: 0
name: Glycylproline
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/79101
is: HMDB00721
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_aad49804_3092_4095_9199_07615234c951
is: SBO:0000252
has only substance units: false
name: LPL
initial amount: NaN
is: P06858
constant: false
boundary condition: true
is encoded by: hsa:4023
initial concentration: NaN
type: Species

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaR FTHFLm
name: formate-tetrahydrofolate ligase, mitochondrial
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reactant: MODEL1310110050#
is: SBO:0000176
fast: false
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_299a5d24_483e_496e_be51_535268c42cff
has only substance units: false
boundary condition: true
is: SBO:0000297
initial amount: NaN
has part: P56134
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
is encoded by: hsa:522
initial concentration: NaN
is encoded by: hsa:9551
constant: false

metaR TYMSFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185
type: Reaction
name: Tyramine O-sulfate transport (diffusion)
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3f8baf4f_c48a_4cfe_8817_2e07897649e4
boundary condition: true
is: SBO:0000252
name: GLUD2
initial concentration: NaN
is: P49448
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:2747

metaR NACHEXA6ly
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176

metaR BUP2
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: false
type: Reaction
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_97cc25db_74ba_4d94_b835_179269c1b528
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2356
has only substance units: false
is: Q05932
name: FPGS

http://identifiers.org/biomodels.db/MODEL1310110050#_44c6f2f8_837e_492e_a757_20f20d38ef83
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:54344
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q86TM7
name: DPM3
type: Species

metaR r0726
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_dab998b0_5c0a_453a_b628_cb13ea2c0d90
initial amount: NaN
initial concentration: NaN
constant: false
is: O60503
has only substance units: false
boundary condition: true
type: Species
name: ADCY9
is encoded by: hsa:115
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_c81ca1f9_6334_4ce1_a827_14c1162e9cf3
initial concentration: NaN
constant: false
is encoded by: hsa:79623
initial amount: NaN
boundary condition: true
type: Species
name: GALNT14
has only substance units: false
is: SBO:0000252
is: Q96FL9

metaR URIDK2m
name: uridylate kinase (dUMP), mitochondrial
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
reactant: MODEL1310110050#
is described by: ECO:0000134

metaR GGH 7DHFe
kinetic law: MODEL1310110050#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000

metaM dgchol x
constant: false
boundary condition: false
type: Species
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
is: SBO:0000247
name: glycochenodeoxycholate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:36252

metaM udp c
name: UDP
is: HMDB00295
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00015
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR r2346
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110050#

metaR S6TASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110050#
fast: false
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM c10crn c
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C17H33NO4 CHARGE: 0
name: decanoyl carnitine
is: HMDB00651
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_a9af48fd_03a3_47b3_abfd_e6ab28e55b79
boundary condition: true
is encoded by: hsa:2109
type: Species
constant: false
name: ETFB
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_5085df11_551b_4af4_8224_02fdc5767efd
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:586
is: P54687
name: BCAT1
type: Species
initial amount: NaN

metaM CE2431 m
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57795
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
has only substance units: false
name: cis-deca-4-enoyl-CoA
constant: false
initial amount: NaN
boundary condition: false

metaM 10fthf7glu l
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](7)

metaM gd1c hs c
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
is: CHEBI:58235
initial concentration: 1.0
boundary condition: false
name: GD1c
is: HMDB00138
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_096cdbe5_6633_46cb_b7b9_8270770596e6
name: PDE3A
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q14432
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5139

http://identifiers.org/biomodels.db/MODEL1310110050#_a820b62b_eae1_4bb4_9d1d_871d73db0516
type: Species
is encoded by: hsa:51102
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: MECR
is: Q9BV79
constant: false
initial amount: NaN

metaR r0724
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
fast: false
reversible: true
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000176
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/2.7.1.33

metaR RPE
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
name: ribulose 5-phosphate 3-epimerase
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/5.1.3.1

metaR CRVNCtr
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110050#

metaM 10fthf7glu m
name: 10-formyltetrahydrofolate-[Glu](7)
is: SBO:0000247
constant: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM 3odcoa m
is: CHEBI:28528
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 3-Oxodecanoyl-CoA
is: HMDB03939
initial amount: NaN
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_88f5ee89_360e_45a8_a861_d94ee1f82c9c
is: SBO:0000252
name: SLCO3A1
is: Q9UIG8
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:28232
boundary condition: true
constant: false
has only substance units: false

metaR C8DCc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaM c10crn e
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C17H33NO4 CHARGE: 0
is: HMDB00651
is: SBO:0000247
name: decanoyl carnitine
constant: false
initial amount: NaN

metaR r2344
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110050#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110050#

metaR r0723
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110050#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
fast: false

metaM udp e
constant: false
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: UDP(3-)
boundary condition: false
has only substance units: false
is: CHEBI:58223

metaM CE0713 m
initial concentration: 1.0
constant: false
is: HMDB02329
is: CHEBI:30623
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
type: Species
name: 3-oxolinoleoyl-CoA
has only substance units: false
initial amount: NaN

metaR GT1Ate
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reversible: true
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
type: Reaction
reactant: MODEL1310110050#
fast: false
name: gt1a hs transport

http://identifiers.org/biomodels.db/MODEL1310110050#_fa3a87c1_38d8_4308_8ef2_0168e93eb706
boundary condition: true
is encoded by: hsa:28976
is: Q9H845
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: ACAD9

metaM ksi pre30 g
type: Species
constant: false
boundary condition: false
is: CHEBI:2504
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: SBO:0000247
initial amount: NaN
is: HMDB06552
name: keratan sulfate I biosynthesis, precursor 30
initial concentration: 1.0
has only substance units: false

metaM acnacngalgbside hs e
has only substance units: false
type: Species
constant: false
name: disialyl galactosylgloboside
initial amount: NaN
is: C00036
is: SBO:0000247
is: HMDB00223
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
is: CHEBI:3338

http://identifiers.org/biomodels.db/MODEL1310110050#_8f5e8ba9_4c6e_4d21_ba83_b7144e89bdcf
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q99755
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:8394
name: PIP5K1A

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM 44mzym r
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial concentration: 1.0
type: Species
has only substance units: false
name: 14-demethyllanosterol
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01286
initial amount: NaN
is: CHEBI:18364

metaR HPYRRy
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.79
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
name: Hydroxypyruvate reductase (NADPH)
reactant: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
is: SBO:0000176

metaM 2mcit e
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
name: 2-methylcitrate(3-)
initial concentration: 1.0
constant: false
is: HMDB00379
boundary condition: false
is: CHEBI:15598
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0267
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.5.1.9
is: SBO:0000176
modifier: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_a65338ab_2626_425d_9562_9bd88a9b3583
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _AI653169_1_c
is encoded by: hsa:AI653169
type: Species

metaR FUMAC
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
name: fumarylacetoacetase
type: Reaction
is version of: http://identifiers.org/ec-code/3.7.1.2

metaM hspg l
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17899
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
has only substance units: false
name: heparan sulfate proteoglycan
boundary condition: false
constant: false
is: HMDB01993
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_133d9a60_d7e2_477f_b7c9_d4b27657a680
type: Species
is encoded by: hsa:4700
initial concentration: NaN
name: NDUFA6
has only substance units: false
is: P56556
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM pglyc hs c
name: pglyc_hs[c]
is: CHEBI:21338
initial concentration: 1.0
is: HMDB02704
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: CHARGE: 0

metaR NDPK3n
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_1912eb27_d7fd_4716_82c5_96c9b9e1086b
boundary condition: true
name: _AI694761_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI694761
type: Species
constant: false

metaR r0268
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
reversible: true
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.3.1
product: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000

metaR AG13T14g
modifier: MODEL1310110050#
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110050#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_bd0c2f48_2ccb_438e_baab_f22bd7440dce
is: P48735
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:3418
initial concentration: NaN
is: SBO:0000252
type: Species
name: IDH2
constant: false

metaR DPCOAPPe
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
name: Pyrophasphatase (dephospho-CoA, extracellular)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_c481627b_8241_4f0d_9ebd_9ed8725d46f3
is: O14734
initial amount: NaN
is encoded by: hsa:10005
type: Species
name: ACOT8
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM acnacngalgbside hs g
initial concentration: 1.0
name: disialyl galactosylgloboside
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:3338
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: HMDB00223
is: C00036

metaR PROSTGH2t
fast: false
product: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000269
name: Prostaglandin H2 transport
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
reactant: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_2a1c7a97_77f1_4751_af8e_3df810206a90
initial concentration: NaN
has only substance units: false
name: ST3GAL3
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_b54f2929_8ef3_463b_8d35_8d68d427cfd3
constant: false
name: MTMR1
type: Species
is: Q13613
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:8776

metaM 2mcit c
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00379
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
is: SBO:0000247
type: Species
is: CHEBI:15598
initial amount: NaN
name: 2-methylcitrate(3-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_646dfd07_6fb8_4588_b6c4_7faa1e0f4c01
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q9UNP4
initial amount: NaN
is encoded by: hsa:8869
has only substance units: false
name: ST3GAL5
initial concentration: NaN

metaR SUCCt4 2
modifier: MODEL1310110050#
is described by: ECO:0000269
name: succinate transport via sodium symport
fast: false
kinetic law: MODEL1310110050#
reversible: true
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is: SBO:0000185
product: MODEL1310110050#

metaR EX coumarin LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: coumarin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_4addbb2a_c0cb_46ea_a0e8_ff5ab14750d1
type: Species
boundary condition: true
is encoded by: hsa:9551
is: P56134
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: ATP5J2

metaM ksi pre3 g
initial concentration: 1.0
is: HMDB06552
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: CHEBI:2504
name: keratan sulfate I biosynthesis, precursor 3
constant: false
boundary condition: false
has only substance units: false

metaR ATPtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
product: MODEL1310110050#
name: ATP transporter, peroxisomal
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110050#

metaM adpac x
constant: false
is: HMDB00448
notes: FORMULA: C6H8O4 CHARGE: -2
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: adipic acid
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_a435e9bc_cef2_4808_b0a3_58c80d2356e6
boundary condition: true
is: SBO:0000252
constant: false
is: P51648
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:224
name: ALDH3A2
type: Species

metaR r0531
modifier: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000000
fast: false

metaR PSDm hs
fast: false
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.1.1.65
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
product: MODEL1310110050#
name: Phosphatidylserine decarboxylase
kinetic law: MODEL1310110050#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110050#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_230374d7_5c93_4725_9531_77030c4a02c7
is: O95299
initial amount: NaN
boundary condition: true
is encoded by: hsa:4705
name: NDUFA10
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR PPPG9tm
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
product: MODEL1310110050#
name: protoporphyrinogen IX mitochondrial transport
reactant: MODEL1310110050#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM retinol e
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00305
boundary condition: false
name: retinol
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: CHEBI:50211
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3dd50cde_9011_410a_8896_ca0575f605e6
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: _100287639_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:100287639
type: Species

metaM decdicoa c
has only substance units: false
is: HMDB01168
name: decadienoylcoa
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
type: Species

metaR RTOTAL2t
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
type: Reaction
name: RTOTAL2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110050#

metaM q10h2 e
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
is: SBO:0000247
has only substance units: false
is: HMDB13111
initial amount: NaN

metaM glu5sa m
initial concentration: 1.0
name: L-Glutamate 5-semialdehyde
is: CHEBI:17232
constant: false
type: Species
is: C01165
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247
has only substance units: false
is: HMDB02104

http://identifiers.org/biomodels.db/MODEL1310110050#_754981dd_26d0_471c_bf3a_d0432105d1c2
is: B4DXZ1
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:440
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ASNS

metaR It
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000185
name: Iodide uniport
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_52739bf0_71df_423d_a262_a82a442d87cb
has only substance units: false
is encoded by: hsa:1119
initial concentration: NaN
is: SBO:0000252
is: P35790
boundary condition: true
name: CHKA
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_1e92b730_fb66_4a80_ba22_a3c216380c12
type: Species
has only substance units: false
is: SBO:0000252
name: PFKP
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:5214
initial amount: NaN
is: Q5VSR7

metaM man c
is: CHEBI:16024
is: SBO:0000247
type: Species
is: C00159
is: HMDB00169
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: D-Mannose

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM dmnoncrn x
initial amount: NaN
is: HMDB06202
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H37NO4 CHARGE: 0
type: Species
name: 4,8-dimethylnonanoyl carnitine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_6f870bb1_d707_4cb9_adb1_b4674e10bc39
is encoded by: hsa:25830
boundary condition: true
is: Q9BR01
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: SULT4A1
type: Species
initial concentration: NaN

metaM glyb m
initial amount: NaN
name: glycine betaine
type: Species
constant: false
is: CHEBI:17750
initial concentration: 1.0
is: HMDB00043
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaR TMDPPK
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 2.7.6.2 Confidence Level: 2 AUTHORS: PMID:8522961 NOTES:also EC 2.7.6.2 - NCD
product: MODEL1310110050#
is: SBO:0000176
type: Reaction
name: thiamine-diphosphate kinase
reversible: false
is described by: ECO:0000000

metaR GT1Atg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
name: gt1a hs intracellular transport

metaR RE3381E
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
name: RE3381
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110050#_0e755c89_ca5a_48e3_9d12_7ba618f975a8
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:50940
constant: false
name: PDE11A
is: SBO:0000252
has only substance units: false
is: Q9HCR9
initial concentration: NaN

metaM retinol c
initial concentration: 1.0
name: retinol
is: CHEBI:50211
is: HMDB00305
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaR NDPK3m
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000254
reactant: MODEL1310110050#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
modifier: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_e99128ac_cb82_40a3_8e38_e989c251fced
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:51809
is: SBO:0000252
name: GALNT7
is: Q86SF2

metaR GPIMTer L
product: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum

metaM q10h2 c
is: HMDB13111
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247

metaR GALC
is: SBO:0000176
reversible: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ
fast: false
type: Reaction
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.46
name: Galactocerebrosidase
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaM HC02205 c
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28099
name: prostaglandin-b2
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

http://identifiers.org/biomodels.db/MODEL1310110050#_50b30961_3c1a_47ef_9f5a_bcd55709a073
is: SBO:0000297
has only substance units: false
name: NME1:NME2
is encoded by: hsa:4830
has part: P22392
initial amount: NaN
is encoded by: hsa:4831
boundary condition: true
has part: P15531
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_78ceb11c_a448_432b_8a73_2343c38089ff
is encoded by: hsa:2805
has only substance units: false
constant: false
is: P17174
initial concentration: NaN
is: SBO:0000252
name: GOT1
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_c2d1a386_c23c_41e6_89e8_2fa1e9b254a5
boundary condition: true
constant: false
initial concentration: NaN
is: Q96SL4
name: GPX7
is: SBO:0000252
is encoded by: hsa:2882
initial amount: NaN
type: Species
has only substance units: false

metaM mmcoa R m
name: (R)-methylmalonyl-CoA(5-)
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
type: Species
is: CHEBI:57326
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01269
initial concentration: 1.0
has only substance units: false

metaR SRTNt6 2 r
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
is: SBO:0000185

metaM hspg e
initial amount: NaN
is: HMDB00719
is: SBO:0000247
initial concentration: 1.0
name: heparan sulfate proteoglycan
has only substance units: false
is: CHEBI:15699
boundary condition: false
type: Species
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5ea506e9_2cb9_41eb_b681_99b910d25411
name: COX6A2
is encoded by: hsa:1339
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q02221
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_ed9dd00d_f80a_41eb_8cc1_b9f985182f34
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9962
initial amount: NaN
type: Species
name: SLC23A2
is: SBO:0000252
boundary condition: true

metaM cholp c
is: CHEBI:295975
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
boundary condition: false
name: choline phosphate(1-)
initial concentration: 1.0
type: Species

metaM apoC Lys m
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
initial amount: NaN
is: HMDB00182
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32551
name: Apocarboxylase (Lys residue)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_83c79bcc_5661_4c6b_84d2_f68f9f01be87
is: SBO:0000252
name: FECH
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2235
constant: false
is: P22830

metaR ARACHDt2
reversible: true
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
name: fatty acid transport via diffusion
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_6176e797_c132_4376_8ddd_2a0f0fcd6f0c
type: Species
has only substance units: false
is: D9HTE9
initial concentration: NaN
is encoded by: hsa:6576
initial amount: NaN
constant: false
name: SLC25A1
boundary condition: true
is: SBO:0000252

metaR FPGS9m
type: Reaction
reactant: MODEL1310110050#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: folylpolyglutamate synthetase (10fthf), mitochondrial
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
product: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.3.2.17

http://identifiers.org/biomodels.db/MODEL1310110050#_30a6d42c_beba_487a_a481_4203f2be5de1
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:883
is: Q16773
constant: false
name: CCBL1

http://identifiers.org/biomodels.db/MODEL1310110050#_5b147b08_a949_4675_a083_779f1b1b2c93
is encoded by: hsa:8802
has only substance units: false
initial concentration: NaN
is: P53597
initial amount: NaN
name: SUCLG1
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28099
has only substance units: false
constant: false
name: prostaglandin-b2
type: Species
initial concentration: 1.0

metaM bilirub r
name: bilirubin(2-)
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00054
is: SBO:0000247
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaR 3AIBTm
modifier: MODEL1310110050#
name: L-3-aminoisobutyrate transaminase, mitochondrial
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110050#
is described by: ECO:0000304
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19
fast: false
is: SBO:0000176
type: Reaction

metaR PCHOLPm hs
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000269
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
name: choline phosphatase
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
modifier: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
type: Reaction

metaR r0423
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#

metaR RE3245C
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
name: RE3245
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton

http://identifiers.org/biomodels.db/MODEL1310110050#_b6512be5_cc7a_4d1f_af13_e128a9ef5b7d
is: SBO:0000252
boundary condition: true
name: SLC24A2
is: Q9UI40
type: Species
has only substance units: false
is encoded by: hsa:25769
constant: false
initial concentration: NaN
initial amount: NaN

metaR A4GNT2g
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
fast: false
modifier: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_bde5d3ff_a898_4c0e_9f06_6d59d734b39a
name: CHKB
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:1120
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: A0PJM6

metaM cbasp c
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: HMDB00828
type: Species
is: CHEBI:32814
is: C00438

metaR r0879
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
fast: false
reactant: MODEL1310110050#
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reversible: false
product: MODEL1310110050#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_b4668406_d435_4d52_8d75_c60c74b2bd3d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2876
initial amount: NaN
type: Species
boundary condition: true
name: GPX1
constant: false
is: P07203

metaR DNDPt8m
is described by: ECO:0000269
name: dADP transport via dUDP antiport
reversible: false
is: SBO:0000185
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110050#_ba81a47d_b105_4677_8894_e59dcd0ec5e4
constant: false
has only substance units: false
boundary condition: true
name: AMY1C
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:278
initial amount: NaN
is: P04745

http://identifiers.org/biomodels.db/MODEL1310110050#_78b8ef88_5963_4f10_bffa_6fe24aeeb204
boundary condition: true
type: Species
is encoded by: hsa:5167
initial amount: NaN
has only substance units: false
is: P22413
is: SBO:0000252
initial concentration: NaN
constant: false
name: ENPP1

metaR GLCNACPT L
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.8.15
kinetic law: MODEL1310110050#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
product: MODEL1310110050#
modifier: MODEL1310110050#

metaR PI4PLC
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4-phosphate phospholipase C
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
type: Reaction
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_96a8556d_f742_443c_8e7e_907c9e326c6b
initial amount: NaN
has only substance units: false
name: RDH12
type: Species
is: SBO:0000252
is: Q96NR8
constant: false
is encoded by: hsa:145226
boundary condition: true
initial concentration: NaN

metaM tsul m
is: SBO:0000247
is: CHEBI:16094
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
constant: false
initial amount: NaN
type: Species
is: HMDB00257
has only substance units: false
name: thiosulfate(2-)
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_0d6c59a6_703a_49b7_9d63_d0706cb00314
constant: false
boundary condition: true
is: Q9NRZ7
is encoded by: hsa:56894
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: AGPAT3
type: Species

metaR ACGAM2E
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
name: N-acetylglucosamine 2-epimerase
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.8
modifier: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (5973.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.8 Confidence Level: 4 AUTHORS: PMID:12499362 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_a2c286be_a3f7_4afd_a35f_f0bc7697ef35
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: _22305_1_c
is encoded by: hsa:22305
has only substance units: false

metaM kynate c
constant: false
boundary condition: false
is: HMDB00715
name: kynurenate
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
type: Species
is: CHEBI:58454
initial concentration: 1.0

metaM pre prot r
is: CHEBI:16038
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: glycophosphatidylinositol (GPI)-anchored protein precursor
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: XY CHARGE: 0

metaR ICDHyrm
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000269
name: Isocitrate dehydrogenase (NADP+)
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
fast: false
reversible: true
type: Reaction

metaR ATPtn
product: MODEL1310110050#
is: SBO:0000185
fast: false
name: ATP diffusion in nucleus
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110050#

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_1790bdcb_9dd2_4c72_942c_45ba99ee13b2
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P48426
name: PIP4K2A
is encoded by: hsa:5305

metaM cholp g
initial amount: NaN
type: Species
is: CHEBI:295975
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: C00588
name: choline phosphate(1-)

metaR r0157
is: SBO:0000176
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110050#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
type: Reaction
reactant: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.3.4.2

metaR r1801
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#

metaR r0426
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is: SBO:0000176
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.5.1.34
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction

metaR ADSL1
is described by: ECO:0000269
name: adenylosuccinate lyase
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.3.2.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_68a50564_997b_44a5_aa9d_c4ca61dfb53a
is: SBO:0000252
has only substance units: false
is: Q6P4B4
boundary condition: true
initial concentration: NaN
name: PFAS
constant: false
is encoded by: hsa:5198
initial amount: NaN
type: Species

metaM ach n
initial amount: NaN
is: HMDB00895
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:15355
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
has only substance units: false

metaM dopasf c
name: dopamine 3-O-sulfate
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
type: Species
constant: false
initial amount: NaN
is: CHEBI:37946
boundary condition: false
is: HMDB06275
is: SBO:0000247
has only substance units: false

metaR ATPtm
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110050#
type: Reaction
name: ADP/ATP transporter, mitochondrial
is: SBO:0000185
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_d06f4fca_1777_49be_ab3b_3fe51da23aa6
type: Species
initial concentration: NaN
is: SBO:0000252
is: O95954
boundary condition: true
name: FTCD
initial amount: NaN
constant: false
is encoded by: hsa:10841
has only substance units: false

metaM cbasp e
is: CHEBI:32814
is: SBO:0000247
is: HMDB00828
initial concentration: 1.0
has only substance units: false
is: C00438
type: Species
initial amount: NaN
notes: FORMULA: C5H6N2O5 CHARGE: -2
name: N-Carbamoyl-L-aspartate
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_c6a4e6a7_eeae_4b9c_818d_19b21eb5e6b1
has only substance units: false
is: O75874
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: IDH1
initial amount: NaN
is encoded by: hsa:3417

metaM dhbpt c
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: 6,7-dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
boundary condition: false
is: CHEBI:20680
type: Species
is: HMDB00038
initial amount: NaN

metaM tetdece1coa c
has only substance units: false
initial amount: NaN
name: tetradecenoylcoa
type: Species
is: HMDB05066
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4

metaM Rtotal2 e
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
is: SBO:0000247
is: C00255
name: R total 2 position
has only substance units: false
is: HMDB00244
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:3554

metaR r0424
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110050#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.1.4
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

metaR RE2972M
is: SBO:0000176
reactant: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
modifier: MODEL1310110050#
type: Reaction
name: RE2972
product: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.67

metaR BILIRED
is version of: http://identifiers.org/ec-code/1.3.1.24
name: Nad(p)h biliverdin reductase
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
product: MODEL1310110050#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_b160bcd7_8371_4565_a1fc_c5d43eb6d7e6
constant: false
is: P19440
name: GGT1
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2678
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_b7f2e8b3_a306_4658_83b1_847231d95efa
name: ALDH9A1
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:223
initial concentration: NaN
is: SBO:0000252
type: Species
is: P49189

http://identifiers.org/biomodels.db/MODEL1310110050#_41a90cbc_d5e5_4d5f_8667_135dfea6d369
constant: false
boundary condition: true
is encoded by: hsa:4846
has only substance units: false
is: A0S0A7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: NOS3

http://identifiers.org/biomodels.db/MODEL1310110050#_d9f855c0_9a05_412e_8db0_cbbf748d0640
initial concentration: NaN
is: SBO:0000252
is: P49619
type: Species
constant: false
boundary condition: true
has only substance units: false
name: DGKG
is encoded by: hsa:1608
initial amount: NaN

metaM Rtotal2 c
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
boundary condition: false
type: Species
is: C00055
is: SBO:0000247
is: HMDB00095
has only substance units: false
is: CHEBI:60377
initial concentration: 1.0
name: R total 2 position
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_7e7640b7_6253_47b5_b06e_b1c0899594f8
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6531
constant: false
has only substance units: false
boundary condition: true
name: SLC6A3
is: Q01959

metaR r0425
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.1.4
kinetic law: MODEL1310110050#
fast: false
name: EC:1.1.1.42
modifier: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_990701b8_dc41_416d_b6dd_cde3496e4a6e
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: _AI971036_1_m
initial concentration: NaN
is encoded by: hsa:AI971036
boundary condition: true
constant: false

metaR r0166
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
reversible: false
fast: false
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_fa261249_6786_41e5_8865_a322a82ebbbc
initial concentration: NaN
type: Species
is: P15848
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:411
name: ARSB

http://identifiers.org/biomodels.db/MODEL1310110050#_a948ef4d_d445_4766_a1a3_cb0f4e21f264
is: Q92523
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1375
has only substance units: false
type: Species
name: CPT1B
boundary condition: true

metaM Nacasp c
name: N-acetyl-L-aspartate(2-)
is: CHEBI:16953
boundary condition: false
is: HMDB00812
type: Species
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR Coqe
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: Transport of q10
is: SBO:0000185

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_2df4f757_cce1_48c0_b3d1_1052bdf563a9
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:AI348006
name: _AI348006_1_c
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM ksi pre6 g
notes: FORMULA: C107H174N7O80SX CHARGE: -2
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06552
is: CHEBI:2504
type: Species
name: keratan sulfate I biosynthesis, precursor 6
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3b7527f3_9a20_496e_bca5_1739b3015602
initial concentration: NaN
name: SUCLG2:SUCLG1
type: Species
has only substance units: false
initial amount: NaN
has part: Q96I99
is encoded by: hsa:8801
is encoded by: hsa:8802
constant: false
boundary condition: true
is: SBO:0000297
has part: P53597

http://identifiers.org/biomodels.db/MODEL1310110050#_ff565f5a_2efd_4fbc_bd57_98d0cc3c982b
constant: false
initial amount: NaN
type: Species
name: SULT1A1
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6817
initial concentration: NaN

metaR RE1709C
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
name: RE1709
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

metaM nad c
is: SBO:0000247
is: C00003
initial concentration: 1.0
is: HMDB00902
constant: false
name: Nicotinamide adenine dinucleotide
boundary condition: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
initial amount: NaN

metaM hs deg7 l
initial amount: NaN
name: heparan sulfate, degradation product 7
boundary condition: false
is: HMDB06254
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false

metaM pmtcrn c
initial amount: NaN
is: SBO:0000247
is: HMDB00222
boundary condition: false
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
constant: false
name: L-palmitoylcarnitine
has only substance units: false
is: CHEBI:17490

metaR UDPACGALtl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
name: udpacgal intracellular transport
fast: false
is described by: ECO:0000000

metaM 4fumacac c
name: 4-fumarylacetoacetate(2-)
boundary condition: false
constant: false
has only substance units: false
is: HMDB01268
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
type: Species
is: CHEBI:18034
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_1c5de40d_fd31_4fe6_9e3d_b79dc6da4e1e
type: Species
boundary condition: true
name: AGXT2L1
initial amount: NaN
constant: false
has only substance units: false
is: Q8TBG4
is encoded by: hsa:64850
is: SBO:0000252
initial concentration: NaN

metaR r0870
fast: false
reversible: true
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.6.4.13
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
type: Reaction
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.7.72
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.3.4
modifier: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_509d6540_0c58_41cd_810c_0c45605fcb5a
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: Q9P0Z9
is encoded by: hsa:51268
is: SBO:0000252
initial concentration: NaN
name: PIPOX
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_9dc7df54_08e9_46fc_a0f8_73a2b65b5487
boundary condition: true
initial concentration: NaN
constant: false
is: P16278
is encoded by: hsa:2720
has only substance units: false
name: GLB1
is: SBO:0000252
initial amount: NaN
type: Species

metaM val L m
is: CHEBI:16414
constant: false
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00883
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_7ccc6fab_3528_4572_9057_e8ff807f99f5
is: SBO:0000252
name: _AI990637_1_x
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AI990637

metaR ACOAD8m
reversible: false
modifier: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.99.10
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
fast: false

metaR ALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
reversible: true
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110050#
type: Reaction
is: SBO:0000185
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_721033bb_52c5_4e94_832b_f7ce2beb5215
type: Species
name: ACSL3
is: O95573
is encoded by: hsa:2181
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_cc8e6cd3_0948_4123_9346_944245c67aa7
boundary condition: true
name: COX7B
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:1349
is: P24311
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_1c7e0956_c3e1_4973_aa44_465ea502d740
is: SBO:0000252
name: PLCG1
boundary condition: true
constant: false
is: Q9UFY1
is encoded by: hsa:5335
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM gd1b hs g
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: GD1b
is: CHEBI:28648
constant: false

metaM pydam c
initial amount: NaN
name: Pyridoxamine
is: HMDB01431
type: Species
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: C00534
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57761
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_1f4026fd_4ba6_4934_9530_675ab8d9b795
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ALDH1B1
initial concentration: NaN
has only substance units: false
is: P30837
is encoded by: hsa:219
type: Species

metaM nicrnt c
is: C01185
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:57502
is: HMDB01132
name: Nicotinate D-ribonucleotide
type: Species
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185

http://identifiers.org/biomodels.db/MODEL1310110050#_44978659_b909_48b7_8fb9_12abdd1d8baa
name: DGUOK
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: E5KSL5
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1716

metaR H3ETer
kinetic law: MODEL1310110050#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
type: Reaction
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
reactant: MODEL1310110050#
reversible: false
product: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
fast: false
is described by: ECO:0000304

metaM apoC Lys c
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false
is: SBO:0000247
is: HMDB00182
name: Apocarboxylase (Lys residue)
initial concentration: 1.0
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110050#_ed0fa71b_2a29_49df_91a8_84e7874114d1
initial amount: NaN
boundary condition: true
name: ALAD
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:210
constant: false
is: Q6ZMU0
has only substance units: false

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Propenoyl-CoA hydrolase (m)
type: Reaction
is described by: ECO:0000134

metaR ADSL2
fast: false
is: SBO:0000176
name: adenylosuccinate lyase
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.3.2.2
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#

metaR ABTArm
modifier: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
reversible: true
is described by: ECO:0000269
is: SBO:0000176
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.6.1.19
kinetic law: MODEL1310110050#

metaR r1650
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110050#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_e0c6a8c6_7e28_42b5_bbc7_ae860ed56b17
type: Species
initial amount: NaN
is: P07864
is encoded by: hsa:3948
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: LDHC
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_d22caac1_f1ea_4e10_b4d9_bde577512ff3
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: P56381
has only substance units: false
initial amount: NaN
is encoded by: hsa:514
is: SBO:0000252
name: ATP5E

metaM orn e
is: CHEBI:0
initial amount: NaN
has only substance units: false
is: C01602
name: Ornithine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00214
boundary condition: false
type: Species
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaM ksi pre25 g
name: keratan sulfate I biosynthesis, precursor 25
type: Species
constant: false
is: HMDB06552
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
has only substance units: false
boundary condition: false
is: CHEBI:2504

metaR GALU
is version of: http://identifiers.org/ec-code/2.7.7.9
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110050#
name: UTP-glucose-1-phosphate uridylyltransferase

metaM o2 m
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00007
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
type: Species
is: CHEBI:15379
is: HMDB01377
initial concentration: 1.0

metaR FAS100COA
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty acyl-CoA synthase (n-C10:0CoA)
product: MODEL1310110050#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110050#

metaR r1651
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110050#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_f2fe3eba_9552_4bc3_8418_ddf7f8bbffbd
name: _AV717590_1_m
type: Species
is encoded by: hsa:AV717590
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM HC00591 c
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN
is: CHEBI:16769
boundary condition: false
has only substance units: false
type: Species
name: 2-oxoglutaramate
is: SBO:0000247
constant: false

metaR S6T11g
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110050#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110050#_644b6efd_fbe4_4603_99c9_8a89cff39b18
is encoded by: hsa:55907
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q8NFW8
boundary condition: true
has only substance units: false
name: CMAS
is: SBO:0000252

metaR GALT
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: galactose-1-phosphate uridylyltransferase
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
reversible: true

metaR r1652
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR 4MOPt2im
type: Reaction
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reversible: false
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

metaM orn c
boundary condition: false
is: CHEBI:0
is: C01602
is: SBO:0000247
type: Species
is: HMDB00214
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Ornithine
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1

http://identifiers.org/biomodels.db/MODEL1310110050#_30dfca6d_dd4b_4eea_8ddc_d586e5341823
is: SBO:0000252
is: E2QC23
initial concentration: NaN
constant: false
name: GCAT
type: Species
boundary condition: true
is encoded by: hsa:23464
has only substance units: false
initial amount: NaN

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06487
name: pentaglutamyl folate (DHF)
constant: false

metaM subeac x
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB00893
notes: FORMULA: C8H12O4 CHARGE: -2
has only substance units: false
name: suberic acid

http://identifiers.org/biomodels.db/MODEL1310110050#_ad1b8d81_ca7a_48f4_bd1e_60823ad645b2
is: B3KMA6
boundary condition: true
initial amount: NaN
is encoded by: hsa:2181
name: ACSL3
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_c707835e_3515_42ea_a2fd_e1922bad2bae
is: SBO:0000252
name: ETFDH
has only substance units: false
initial amount: NaN
is: Q16134
constant: false
type: Species
boundary condition: true
is encoded by: hsa:2110
initial concentration: NaN

metaR r1653
modifier: MODEL1310110050#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
fast: false

metaM ppi x
type: Species
constant: false
name: Diphosphate
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
initial amount: NaN
is: C00013
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:33019

http://identifiers.org/biomodels.db/MODEL1310110050#_dac267d6_2d64_4e91_926b_bffde9792c15
is: B3KT19
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: PIK3R1
is encoded by: hsa:5295
initial concentration: NaN
constant: false

metaR LTD4DP
kinetic law: MODEL1310110050#
is described by: ECO:0000000
name: Leukotriene D4 dipeptidase
reversible: true
fast: false
type: Reaction
product: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_4449dce2_e1c7_4f7a_a3b4_b79797bd0d3a
is encoded by: hsa:517
has only substance units: false
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has part: Q06055
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_331b88e7_3ac1_4aaf_8db0_f700c1dcbdbc
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:493
boundary condition: true
name: ATP2B4
is: P23634
initial amount: NaN

metaR RE3244R
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110050#
name: RE3244
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reactant: MODEL1310110050#
fast: false
is: SBO:0000176
product: MODEL1310110050#

metaM tag hs c
boundary condition: false
is: SBO:0000247
name: triglyceride
type: Species
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17855

metaR MCCCrm
name: methylcrotonoyl-CoA carboxylase, mitochondrial
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.4.1.4
is described by: ECO:0000269
kinetic law: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false

metaR r1654
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reversible: true

metaM man g
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
is: CHEBI:16024
has only substance units: false
is: HMDB00169
initial concentration: 1.0
type: Species
is: SBO:0000247
name: D-mannose
initial amount: NaN

metaR r1090
type: Reaction
fast: false
reactant: MODEL1310110050#
reversible: false
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_6a5196f9_a11d_4448_b222_1fbb408bda29
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: CHAT
is encoded by: hsa:1103
is: Q6LEN6
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_569ce8df_2e1c_4174_9652_3c1047090ee4
is: P05181
boundary condition: true
initial amount: NaN
has only substance units: false
name: CYP2E1
is encoded by: hsa:1571
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_d1f2bd58_b032_44bd_ac06_8846bbc561b4
name: DPYSL2
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: B4DR31
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1808

metaR GMPtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185
name: GMP transport (Golgi)
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_e758f85b_c21a_4a7c_95cb_d81191e55017
constant: false
name: TREH
initial amount: NaN
has only substance units: false
is: O43280
type: Species
boundary condition: true
is encoded by: hsa:11181
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_b5b07238_c4ea_455f_8e29_ab97abb232df
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:64834
boundary condition: true
type: Species
name: ELOVL1
has only substance units: false
initial amount: NaN
constant: false
is: Q9BW60

metaR H7 TAer
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
name: H7' transamidase, endoplasmic reticulum
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_6e410675_01ef_407d_8cee_04e39d4a147d
is: SBO:0000252
is encoded by: hsa:9365
has only substance units: false
boundary condition: true
constant: false
name: KL
is: Q9UEF7
type: Species
initial concentration: NaN
initial amount: NaN

metaM cholcoar x
is: HMDB02178
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
type: Species
has only substance units: false
boundary condition: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
constant: false
is: SBO:0000247
is: CHEBI:58677

http://identifiers.org/biomodels.db/MODEL1310110050#_1ae5cb44_6c3b_4219_aa1f_d57b52262a18
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI539321
initial concentration: NaN
name: _AI539321_1_c
constant: false

metaR GLYC3Ptmc
name: glycerol-3-phopshate transport, cytoplasm
is described by: ECO:0000134
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_11f72ace_2f81_4cdf_a7c2_b4d7766d216e
boundary condition: true
constant: false
is encoded by: hsa:AI090874
name: _AI090874_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r1655
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_1875e2cc_1344_463e_adf1_aa0e0c31aa28
constant: false
is encoded by: hsa:3418
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P48735
boundary condition: true
type: Species
name: IDH2
initial amount: NaN

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR PHETHPTOX2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.16.1
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
kinetic law: MODEL1310110050#

metaR r0160
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.1.3.2
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
type: Reaction

metaR PYAM5POr
product: MODEL1310110050#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
name: pyridoxamine 5'-phosphate oxidase
reversible: true
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_58167214_01c6_4267_9b3a_cf3c28bbc8b5
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9NQ66
constant: false
name: PLCB1
is encoded by: hsa:23236
type: Species
initial amount: NaN
initial concentration: NaN

metaM cs a deg4 l
is: HMDB00812
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16953
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
type: Species
initial concentration: 1.0
notes: FORMULA: C31H49NO29S CHARGE: -2

metaM thf c
initial amount: NaN
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: SBO:0000247
boundary condition: false
name: 5,6,7,8-Tetrahydrofolate
type: Species
initial concentration: 1.0
constant: false
is: HMDB01846
has only substance units: false
is: CHEBI:57453
is: C00101

metaM gar c
is: C03838
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
type: Species
initial concentration: 1.0
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457
is: SBO:0000247
is: HMDB02022

http://identifiers.org/biomodels.db/MODEL1310110050#_722c079e_e926_480d_9208_78bf902408a5
is: Q6IRT1
initial amount: NaN
is encoded by: hsa:128
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: ADH5
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_70ee2e9c_c0e6_405c_991c_f6ec221cd77b
initial amount: NaN
has only substance units: false
is encoded by: hsa:4718
type: Species
name: NDUFC2
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q549M5

metaM udpgal g
type: Species
is: CHEBI:58439
constant: false
is: HMDB00302
initial amount: NaN
initial concentration: 1.0
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR r2202
kinetic law: MODEL1310110050#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1656
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110050#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM HC00591 m
initial concentration: 1.0
name: 2-oxoglutaramate
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_5c6f3a1e_8833_47dd_b950_c64a9f4a91b5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9498
type: Species
initial concentration: NaN
is: E7EML0
has only substance units: false
name: SLC4A8
constant: false
initial amount: NaN

metaR THYMDtm
reversible: true
type: Reaction
name: thymd transport
product: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
kinetic law: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110050#

metaR MI3PP
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110050#
reversible: false
product: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 3-phosphatase
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_fc66a5f7_9d97_45cf_a504_eb6a07da1a38
has only substance units: false
boundary condition: true
initial amount: NaN
name: DPM3
initial concentration: NaN
is encoded by: hsa:54344
type: Species
constant: false
is: SBO:0000252
is: Q9P2X0

metaM HC02202 e
is: CHEBI:57398
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: prostaglandin A1(1-)
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_56992273_34ad_4a52_b50e_66691749db07
type: Species
initial concentration: NaN
has only substance units: false
name: DPYS
boundary condition: true
is: SBO:0000252
constant: false
is: Q14117
initial amount: NaN
is encoded by: hsa:1807

metaR r1657
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_fcc150cc_997d_4de5_85d7_59a9c613da7d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55
type: Species
has only substance units: false
constant: false
is: P15309
is: SBO:0000252
name: ACPP
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_0c84a884_71c4_4745_b896_1e10c979392b
has only substance units: false
constant: false
is: Q96G03
name: PGM2
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55276
initial amount: NaN
boundary condition: true

metaR CAt7r
name: calcium / sodium antiporter (1:3), reversible
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
modifier: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110050#

metaM man l
has only substance units: false
name: D-mannose
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
is: SBO:0000247
is: HMDB00169
initial amount: NaN
is: CHEBI:16024

http://identifiers.org/biomodels.db/MODEL1310110050#_ffcc4e44_bd58_4193_be2c_2401a1e2068e
name: IMPA1
is: B7Z6Q4
initial concentration: NaN
constant: false
is encoded by: hsa:3612
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaM bilirub e
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
is: SBO:0000247
type: Species
name: bilirubin(2-)
is: HMDB00054
is: CHEBI:57977
constant: false
boundary condition: false
initial amount: NaN

metaR DOLPGT2 Ler
fast: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
product: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.265

http://identifiers.org/biomodels.db/MODEL1310110050#_74c5f903_d209_4cd4_80a1_d6f571bbcd00
name: _AI191472_1_c
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI191472
initial amount: NaN
constant: false

metaR GLCNACASE2ly
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
reversible: false
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal

metaR G14T14g
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
kinetic law: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
type: Reaction
reactant: MODEL1310110050#
reversible: false

metaR r1658
is: SBO:0000185
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM orn m
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:46912
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Ornithine
boundary condition: false
is: HMDB00214
is: C01602

metaR MACACI
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
reversible: false
is described by: ECO:0000269
name: maleylacetoacetate isomerase

metaR RE1709N
is: SBO:0000176
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
name: RE1709
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110050#
fast: false
reversible: true
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.1.96

http://identifiers.org/biomodels.db/MODEL1310110050#_eb4cce36_639d_475e_9ccd_98fbe36ffad4
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: FH
type: Species
is: P07954
is encoded by: hsa:2271
is: SBO:0000252
initial concentration: NaN

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_15f8c2b0_5623_4ebb_bd97_91e767226a92
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:8818
has part: P37287
initial concentration: NaN
is encoded by: hsa:5277
boundary condition: true
type: Species
is: SBO:0000297
has only substance units: false
constant: false
initial amount: NaN

metaM ppi r
is: CHEBI:33019
is: HMDB00250
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
type: Species
boundary condition: false
name: Diphosphate
initial amount: NaN

metaM o2 e
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
initial concentration: 1.0
name: O2
initial amount: NaN
is: CHEBI:15379
has only substance units: false
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01377

metaR EX 4hdebrisoquine LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4 hydroxy debrisoquine exchange
type: Reaction

metaR r1659
product: MODEL1310110050#
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR BIOCYTtn
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
type: Reaction
reversible: true
name: biocytin transport, nuclear
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
is: SBO:0000185

metaR r0539
is: SBO:0000176
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
fast: false
kinetic law: MODEL1310110050#

metaR GALK
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.1.157
type: Reaction
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
fast: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.1.6
reactant: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
is: SBO:0000176
reversible: false
name: galactokinase

metaR BETALDHxm
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110050#
name: betaine-aldehyde dehydrogenase, mitochondrial
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#

metaM m7mpdol L r
boundary condition: false
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:37636
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_c9568399_f8a1_4762_bf27_1282c1d4ae8a
is encoded by: hsa:8818
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O94777
initial amount: NaN
name: DPM2
is: SBO:0000252
constant: false
type: Species

metaM bilirub c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
is: CHEBI:57977
is: HMDB00054
constant: false
has only substance units: false
name: bilirubin(2-)

metaR CYTK9n
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dCTP),nuclear
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000269
modifier: MODEL1310110050#
type: Reaction

metaM adpac c
notes: FORMULA: C6H8O4 CHARGE: -2
is: HMDB00448
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: adipic acid
constant: false

metaM tag hs e
constant: false
name: triglyceride
initial concentration: 1.0
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:17855
boundary condition: false

metaM dlnlcgcrn c
is: CHEBI:16004
initial amount: NaN
constant: false
is: HMDB01311
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: dihomo-gamma-linolenyl carnitine
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3

metaM udpgal c
type: Species
is: CHEBI:58439
constant: false
initial concentration: 1.0
is: HMDB00302
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
has only substance units: false
name: UDP-D-galactose(2-)
boundary condition: false

metaM e4hglu m
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
type: Species
name: erythro-4-hydroxy-L-glutamate(1-)
is: CHEBI:6331
is: HMDB02273
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaR EX c10crn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_002d319e_3625_46b7_a84c_7cae4834d6ed
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ST3GAL3
has only substance units: false
type: Species
is encoded by: hsa:6487
initial concentration: NaN
constant: false

metaR ACACT10m
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reversible: true
is: SBO:0000176
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#

metaM o2 c
initial concentration: 1.0
is: HMDB01377
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: C00007
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379

metaM cs a deg1 l
is: SBO:0000247
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
type: Species
initial amount: NaN
is: CHEBI:16953
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
constant: false
is: HMDB00812
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM cholcoar r
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
type: Species
has only substance units: false
is: HMDB02178
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58677
initial concentration: 1.0

metaR r0276
is described by: ECO:0000000
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
type: Reaction
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:

metaM glyc S e
name: (S)-Glycerate
notes: FORMULA: C3H5O4 CHARGE: 0
is: CHEBI:33871
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: HMDB06372
initial amount: NaN

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR CHOLK
name: Choline kinase
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_c6aeeb3e_e7c7_4144_a275_4e7a2d02d532
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI972237
boundary condition: true
constant: false
name: _AI972237_1_c

metaR ACACt2
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000185
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is described by: ECO:0000269
name: acetoacetate transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110050#_7e87565f_d2e1_48fb_81f4_5d5aaefa7a95
initial amount: NaN
has only substance units: false
name: _206_1_c
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:206
constant: false
type: Species

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR FUCASE2e
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.51
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
name: alpha-fucosidase, extracellular
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#

metaM idour e
has only substance units: false
name: L-iduronate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:21338
is: HMDB02704
initial amount: NaN

metaM c226coa m
is: C16169
name: cervonyl coenzyme A
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1

metaR RBFK
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110050#
name: riboflavin kinase
product: MODEL1310110050#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.26
reversible: false
kinetic law: MODEL1310110050#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110050#_0e6c6df2_04b5_4edf_8890_bcc972da7d40
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P00568
is encoded by: hsa:203
type: Species
name: AK1
constant: false

metaM ump c
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP
is: C00105
is: HMDB00288
is: CHEBI:57865
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r0522
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#
is: SBO:0000176
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10

metaM HC01412 x
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:61405
initial concentration: 1.0
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
initial amount: NaN
name: trans-tetradec-2-enoyl-CoA(4-)

metaM din e
is: HMDB00071
boundary condition: false
type: Species
name: Deoxyinosine
is: CHEBI:28997
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C05512
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial concentration: 1.0

metaM nad r
is: CHEBI:57540
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: HMDB00902
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: NAD(1-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM leuktrE4 c
name: leukotriene E4(1-)
is: HMDB02200
type: Species
has only substance units: false
is: CHEBI:57462
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_ff765d44_921e_4a6f_9f96_209142dea056
has only substance units: false
constant: false
is: Q8IZH9
initial amount: NaN
is encoded by: hsa:2643
type: Species
is: SBO:0000252
boundary condition: true
name: GCH1
initial concentration: NaN

metaR CHAT
kinetic law: MODEL1310110050#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.6
name: Choline O-acetyltransferase
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
fast: false

metaM arab L e
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
is: CHEBI:30849
initial concentration: 1.0
is: HMDB00646
type: Species
constant: false
name: L-arabinose
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR EX c8crn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaM pydx5p c
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
boundary condition: false
is: HMDB01491
type: Species
is: C00018
is: CHEBI:597326
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: Pyridoxal 5'-phosphate
initial concentration: 1.0

metaM ppi m
initial amount: NaN
name: Diphosphate
is: CHEBI:33019
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
is: HMDB00250
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false

metaR RTOTAL3FATPc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaR EX ddecrn
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaM glyc S c
initial amount: NaN
name: (S)-Glycerate
notes: FORMULA: C3H5O4 CHARGE: 0
constant: false
initial concentration: 1.0
is: CHEBI:33871
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06372
type: Species

metaR RE0453N
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110050#
name: RE0453

http://identifiers.org/biomodels.db/MODEL1310110050#_3b54d426_c82a_4f7a_8d1a_d88c479a8af3
initial concentration: NaN
has only substance units: false
is: P26572
is encoded by: hsa:4245
name: MGAT1
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaR r0523
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is described by: ECO:0000000
modifier: MODEL1310110050#
is: SBO:0000176

metaM retinal c
constant: false
initial concentration: 1.0
is: CHEBI:15035
boundary condition: false
name: retinal
has only substance units: false
initial amount: NaN
is: HMDB01358
is: SBO:0000247
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376

metaM idour c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
is: HMDB02704
initial amount: NaN
name: L-iduronate
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:21338
has only substance units: false

metaR MAL Lte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of L-malate
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
reversible: true
is: SBO:0000185

metaR DM anth
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM 4hglusa m
type: Species
has only substance units: false
initial amount: NaN
is: HMDB06556
constant: false
initial concentration: 1.0
is: CHEBI:27809
is: SBO:0000247
name: L-4-hydroxyglutamic semialdehyde
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
boundary condition: false

metaM ppi n
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
name: diphosphate(3-)
boundary condition: false
is: HMDB00250
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:33019

metaM so3 c
type: Species
has only substance units: false
boundary condition: false
is: HMDB00240
constant: false
is: C00094
initial amount: NaN
name: Sulfite
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: CHEBI:17137

metaM xyl D e
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
initial amount: NaN
is: SBO:0000247
is: CHEBI:15936
constant: false

metaM cs c l
initial amount: NaN
is: CHEBI:36005
is: SBO:0000247
initial concentration: 1.0
constant: false
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
has only substance units: false
boundary condition: false
is: HMDB02183
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
type: Species

metaM ump e
is: CHEBI:57865
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: UMP(2-)

metaR CHOLPtg
product: MODEL1310110050#
reversible: true
type: Reaction
is described by: ECO:0000000
name: choline phosphate intracellular transport
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
kinetic law: MODEL1310110050#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_b343d135_03b4_49b0_8da7_bb96a77dc1f6
is: Q5JAM2
name: ALAS1
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:211
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR CEPTC
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
name: choline phosphotransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.2
reversible: false
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR PEROXx
type: Reaction
fast: false
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: peroxisomal lumped long chain fatty acid oxidation
is: SBO:0000176
reactant: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_d6c1eb81_8232_4ec9_bf73_00687ec4235e
is encoded by: hsa:2683
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: P15291
name: B4GALT1
constant: false
boundary condition: true

metaM nad m
initial concentration: 1.0
is: HMDB00902
type: Species
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: C00003
name: Nicotinamide adenine dinucleotide
has only substance units: false
is: CHEBI:57540
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM 3php c
boundary condition: false
is: CHEBI:18110
is: HMDB01024
name: 3-phosphonatooxypyruvate(3-)
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_fc2bd19d_eda2_4079_8638_fccadf6655ef
boundary condition: true
initial amount: NaN
has only substance units: false
name: COX7A1
constant: false
is: SBO:0000252
is encoded by: hsa:1346
initial concentration: NaN
type: Species
is: P24310

metaM 3hpp m
has only substance units: false
name: 3-hydroxypropionate
initial concentration: 1.0
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: SBO:0000247
is: HMDB00700
constant: false
initial amount: NaN
is: CHEBI:16510
boundary condition: false

metaM dpcoa l
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: 3'-dephospho-CoA(2-)
is: HMDB01373
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57328

http://identifiers.org/biomodels.db/MODEL1310110050#_8d7757a1_0a82_4b42_b5b5_7dfece53951d
has only substance units: false
initial concentration: NaN
name: SPTLC1
initial amount: NaN
is encoded by: hsa:10558
boundary condition: true
type: Species
is: O15269
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_ffdf9c88_96fa_4075_b549_5982fe8bcdd8
has only substance units: false
initial amount: NaN
is: Q13615
boundary condition: true
name: MTMR3
is: SBO:0000252
constant: false
is encoded by: hsa:8897
initial concentration: NaN
type: Species

metaM tdcoa m
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: CHEBI:57385
constant: false
boundary condition: false
is: C02593
is: HMDB01521
type: Species

metaR NACHEX1ly
modifier: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110050#
reversible: false
is: SBO:0000176
fast: false
name: beta-N-acetylhexosaminidase, lysosomal

metaM nad n
boundary condition: false
is: HMDB00902
type: Species
constant: false
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: NAD(1-)
is: CHEBI:57540

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR r1088
name: Active transport
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110050#

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaM dpcoa m
is: SBO:0000247
initial amount: NaN
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR FPGS8m
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
name: folylpolyglutamate synthetase (10fthf), mitochondrial
reactant: MODEL1310110050#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.2.17
modifier: MODEL1310110050#
type: Reaction
is: SBO:0000176

metaM HC00900 c
is: CHEBI:30860
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Methylmalonate
initial amount: NaN
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170

metaR C142CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR FTCD
is version of: http://identifiers.org/ec-code/2.1.2.5
reversible: false
name: formimidoyltransferase cyclodeaminase
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
is: SBO:0000176

metaR NDPK4n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110050#
reversible: true
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_c1bad156_04f4_48c6_89c1_cd6ed2854441
initial amount: NaN
is: Q8IV97
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8140
name: SLC7A5

http://identifiers.org/biomodels.db/MODEL1310110050#_dd72aab4_c306_4e10_865c_05bf779629c8
initial amount: NaN
is: SBO:0000252
type: Species
is: Q92604
is encoded by: hsa:9926
name: LPGAT1
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_b139c64e_0d49_490e_b642_61931889e13e
constant: false
type: Species
boundary condition: true
is: P00390
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2936
initial amount: NaN
has only substance units: false
name: GSR

metaM HC02202 c
name: prostaglandin A1(1-)
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
is: CHEBI:57398
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

metaM malcoa r
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
name: malonyl-CoA(4-)
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57384
is: SBO:0000247
is: HMDB01175

metaM lac L e
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: (S)-lactate
boundary condition: false
has only substance units: false
is: HMDB00190
type: Species
is: CHEBI:16651

metaR r2201
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110050#
modifier: MODEL1310110050#

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_41bbb240_7b34_4c97_a96f_88abda7a1e1c
initial concentration: NaN
boundary condition: true
is: A8K460
is encoded by: hsa:8398
constant: false
name: PLA2G6
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_2091bc21_3f00_4c4f_b76b_f224397fdadd
is: SBO:0000252
type: Species
is: O43678
name: NDUFA2
constant: false
is encoded by: hsa:4695
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR PI45P3K
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
kinetic law: MODEL1310110050#
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false
product: MODEL1310110050#

metaM thf e
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: CHEBI:57453
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
is: HMDB01846

http://identifiers.org/biomodels.db/MODEL1310110050#_36d40071_2164_4c6e_9d05_d8596b5b4b5f
constant: false
is: P23786
name: CPT2
is encoded by: hsa:1376
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_031e6d92_265f_4d74_a407_2ec712540dd2
is encoded by: hsa:64600
initial concentration: NaN
type: Species
boundary condition: true
name: PLA2G2F
initial amount: NaN
is: Q9BZM2
constant: false
has only substance units: false
is: SBO:0000252

metaM din c
is: HMDB00071
name: Deoxyinosine
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:28997
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial amount: NaN
is: C05512
boundary condition: false

metaR r2200
product: MODEL1310110050#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_763f8fa1_70e0_4bff_b7e9_5f2bb28d11b6
type: Species
name: VNN3
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110050#_fecec7c5_66fe_447f_a3cb_05861a70d625
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10846
name: PDE10A
is: Q9Y233
boundary condition: true

metaR FCLTm
type: Reaction
reversible: false
is described by: ECO:0000304
fast: false
reactant: MODEL1310110050#
name: Ferrochelatase, mitochondrial
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
product: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.99.1.1
is: SBO:0000176

metaM arab L c
boundary condition: false
type: Species
is: CHEBI:30849
is: HMDB00646
name: L-arabinose
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

metaR RE1525M
is described by: ECO:0000000
name: RE1525
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110050#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_fa975720_1cfa_4a83_902b_708dc3e73592
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9NYR8
boundary condition: true
is: SBO:0000252
is encoded by: hsa:50700
constant: false
name: RDH8

http://identifiers.org/biomodels.db/MODEL1310110050#_259c320c_00f9_4d6d_8e97_fe92ab2ac1df
is encoded by: hsa:686
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: P43251
name: BTD
boundary condition: true
initial concentration: NaN

metaR RE0908C
name: RE0908
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11861502,PMID:2765556,PMID:3988241,PMID:7263841,PMID:8767510 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
reversible: true
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_8c1061d7_03fe_4028_861f_eaeaafa3b28b
is: SBO:0000252
is encoded by: hsa:2348
has only substance units: false
name: FOLR1
type: Species
boundary condition: true
initial amount: NaN
is: P15328
constant: false
initial concentration: NaN

metaR 4HPRO LTte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000185
name: Transport of trans-4-hydroxy-L-proline
reversible: true
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#

metaR ABUTt2r
type: Reaction
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: 4-aminobutyrate reversible transport in via proton symport
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is: SBO:0000185
fast: false
is described by: ECO:0000304

metaR RE2349C
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
type: Reaction
kinetic law: MODEL1310110050#
name: RE2349
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: true
is: SBO:0000176
fast: false

metaR AKGtp
kinetic law: MODEL1310110050#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
name: AKG transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_eef3e34f_4eb3_4a93_a83f_4fdaa378d9d7
has only substance units: false
constant: false
initial amount: NaN
name: DLD
is encoded by: hsa:1738
initial concentration: NaN
is: SBO:0000252
type: Species
is: P09622
boundary condition: true

metaR SLDt
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
name: L-sulfolactate transport (cytosol to extracellular)
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_adb55044_4c0c_4793_9372_00927de692db
has only substance units: false
type: Species
initial concentration: NaN
is: P11310
name: ACADM
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:34

http://identifiers.org/biomodels.db/MODEL1310110050#_ffdbcea3_4c5b_42a8_bf75_04f772a0627a
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6817
initial amount: NaN
constant: false
boundary condition: true
name: SULT1A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_e052a8c4_ff2e_42c0_bf26_c63865c550f3
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA788780
name: _AA788780_1_c
initial concentration: NaN
boundary condition: true
constant: false

metaM lac L c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: (S)-lactate
is: CHEBI:16651
is: SBO:0000247
constant: false
is: HMDB00190

metaM ha pre1 e
constant: false
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

metaM subeac c
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C8H12O4 CHARGE: -2
boundary condition: false
is: HMDB00893
has only substance units: false
name: suberic acid
initial amount: NaN
is: SBO:0000247

metaR IDOAASE4ly
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.76
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: alpha-L-iduronidase, lysosomal
modifier: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110050#_c2fbb3b0_1e57_48ab_93f0_06f92495a362
initial concentration: NaN
initial amount: NaN
name: _AI915649_1_c
boundary condition: true
constant: false
is encoded by: hsa:AI915649
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_dd54da5e_95f3_4a30_82dd_e860b6d539dd
constant: false
initial amount: NaN
initial concentration: NaN
name: PIGF
type: Species
is encoded by: hsa:5281
is: Q6IB04
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM gdp m
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
constant: false
is: C00035
boundary condition: false
is: SBO:0000247
is: CHEBI:58189
has only substance units: false
name: GDP
type: Species
is: HMDB01201
initial concentration: 1.0

metaR MI1345PP
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.3.56
is described by: ECO:0000269
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
fast: false
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_852c9d54_de14_4d36_b53d_2b3b7a936fa8
name: CA6
boundary condition: true
is encoded by: hsa:765
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: Q5FC00
initial concentration: NaN
has only substance units: false

metaM val L e
has only substance units: false
type: Species
name: L-valine
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
is: CHEBI:16414
is: HMDB00883

metaR FBA2
fast: false
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/4.1.2.13
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase

metaM 4abut e
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:3628
type: Species
initial concentration: 1.0
is: HMDB00112
is: C00334
name: 4-Aminobutanoate
is: SBO:0000247
has only substance units: false

metaM ppi e
is: C00013
initial amount: NaN
is: CHEBI:33019
is: HMDB00250
constant: false
name: Diphosphate
type: Species
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_edb6db0b_322b_42ea_9fc4_3d85e669d9da
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR RE2658R
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2658
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110050#

metaR TYMSULT
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Tyramine Sulfotransferase
fast: false
is described by: ECO:0000269
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_e53b58b6_7ee0_4d2d_b228_dffa7bcf6b50
is encoded by: hsa:84532
is: Q9NUB1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ACSS1
type: Species
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_0c2186d6_0e9f_4ca7_8f6e_bfbd8043107e
is encoded by: hsa:AI818585
has only substance units: false
is: SBO:0000252
name: _AI818585_1_c
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaM betald c
constant: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15710
is: HMDB01252
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: betaine aldehyde

metaR HSD17B4x
fast: false
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
is: SBO:0000176
name: hydroxysteroid (17-beta) dehydrogenase 4
reversible: false
reactant: MODEL1310110050#

metaR AG13T4g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
kinetic law: MODEL1310110050#
reversible: false

metaM gdp n
initial amount: NaN
is: HMDB01201
is: CHEBI:58189
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: GDP(3-)

metaR ARABR
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110050#
is: SBO:0000176
name: arabinose reductase
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
modifier: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_b6456823_b72a_4f89_9efc_04ad508c9cbd
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: GLRX2
has only substance units: false
is encoded by: hsa:51022
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_82482d95_d01c_4974_9301_0c7d464635b8
type: Species
name: ACOT12
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: Q5FWE9
is: SBO:0000252
is encoded by: hsa:134526
initial amount: NaN

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR r0410
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_ea1e8c2e_20b4_4d38_b6e4_3afb042fe1f2
type: Species
has only substance units: false
boundary condition: true
name: PFKL
is encoded by: hsa:5211
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q7L2M7

metaM xyl D l
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15936
boundary condition: false
name: aldehydo-D-xylose
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false

metaR r0149
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
type: Reaction
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_72beae06_1c4e_4784_af3f_79e19833bc55
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:M68895
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _M68895_1_c

metaM idour l
boundary condition: false
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
has only substance units: false
is: CHEBI:21338
initial concentration: 1.0
initial amount: NaN
name: L-iduronate
is: SBO:0000247
is: HMDB02704

http://identifiers.org/biomodels.db/MODEL1310110050#_94d77a93_c9ad_4b6e_a67f_b047de087397
constant: false
is encoded by: hsa:U37519
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _U37519_1_e
is: SBO:0000252

metaM val L c
type: Species
name: L-valine
is: HMDB00883
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16414
initial amount: NaN

metaM ksi pre31 g
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 31
is: CHEBI:2504
is: SBO:0000247
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
has only substance units: false
initial amount: NaN
is: HMDB06552

metaM dpcoa c
type: Species
initial amount: NaN
is: C00882
constant: false
is: CHEBI:57328
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: Dephospho-CoA
initial concentration: 1.0
is: SBO:0000247
is: HMDB01373
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_4c8ae2d5_2be9_46ef_bbd3_465d356c32a8
is encoded by: hsa:226
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: ALDOA
initial concentration: NaN

metaM so3 m
boundary condition: false
initial amount: NaN
is: HMDB00240
name: hydrogensulfite
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:17137
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
has only substance units: false
constant: false

metaR FAOXC18480m
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
is: SBO:0000176
name: Beta oxidation of fatty acid
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110050#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110050#_51fc3f7e_e6d5_4757_b899_ec00f78382be
type: Species
initial amount: NaN
name: _D87002_1_e
boundary condition: true
is encoded by: hsa:D87002
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR DTDPtn
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
name: dTDP nuclear transport
kinetic law: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
fast: false

metaR GALt2 2
modifier: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
is: SBO:0000185
name: D-galactose transport via proton symport
reactant: MODEL1310110050#
reversible: true

metaR SLDx
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.37
reversible: true
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#
product: MODEL1310110050#
name: L-sulfolactate dehydrogenase (NAD+)
fast: false
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272

http://identifiers.org/biomodels.db/MODEL1310110050#_dc4e6d65_4002_4854_923d_45121c0dcc52
name: ST3GAL3
boundary condition: true
initial concentration: NaN
constant: false
is: Q11203
is encoded by: hsa:6487
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM debrisoquine c
has only substance units: false
constant: false
name: debrisoquine
is: SBO:0000247
type: Species
is: CHEBI:34665
notes: FORMULA: C10H14N3 CHARGE: 1 INCHI: InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
boundary condition: false
is: HMDB06543
initial amount: NaN
initial concentration: 1.0

metaM 3mgcoa m
is: CHEBI:57346
boundary condition: false
name: trans-3-methylglutaconyl-CoA(5-)
is: SBO:0000247
initial amount: NaN
is: HMDB01057
constant: false
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial concentration: 1.0
type: Species
has only substance units: false

metaR 1PPDCRp
type: Reaction
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reversible: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is: SBO:0000176
product: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#

metaR DOPAt4 2 r
fast: false
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
modifier: MODEL1310110050#
type: Reaction
name: Dopamine reversible transport in via sodium symport (1:2)
product: MODEL1310110050#
is described by: ECO:0000269
reactant: MODEL1310110050#
reversible: true
kinetic law: MODEL1310110050#

metaM man6p c
type: Species
is: HMDB01078
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
name: D-Mannose 6-phosphate
is: CHEBI:17369
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_31ef8ecf_7c70_48ed_ac10_7c97ac4a5e4e
is encoded by: hsa:123041
name: SLC24A4
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q8NFF2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaR FE3MTP1
is: SBO:0000185
name: transport of ferrous iron into blood
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110050#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_80c9d5b5_a51e_4f19_ab46_24e75413ab3d
constant: false
boundary condition: true
is: Q7Z725
is encoded by: hsa:6569
initial amount: NaN
name: SLC34A1
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR GDPFUCtg
product: MODEL1310110050#
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
name: GDPFuc Golgi transport via CMP antiport

metaM fol e
initial concentration: 1.0
name: Folate
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
has only substance units: false

metaR O2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
name: O2 transport, endoplasmic reticulum
is described by: ECO:0000000

metaM dpcoa e
is: C00882
initial amount: NaN
has only substance units: false
is: CHEBI:57328
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: HMDB01373
name: Dephospho-CoA
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR 10FTHF7GLUtl
is: SBO:0000185
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
name: 7-glutamyl-10FTHF transport, lysosomal
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
fast: false

metaM tdcoa x
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01521
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C02593

metaR XOLDIOLONEt
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_6a667654_3f66_471b_8c9c_4afa4fe7ec0d
is encoded by: hsa:10400
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PEMT
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_51d2adb3_76d9_44e4_a820_40021b15a907
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: MTMR3
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8897

metaM nad x
is: HMDB00902
is: CHEBI:57540
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
constant: false
name: Nicotinamide adenine dinucleotide
boundary condition: false
type: Species
is: C00003
initial concentration: 1.0

metaM crn e
constant: false
is: CHEBI:16347
type: Species
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
is: SBO:0000247
name: L-Carnitine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00318

metaM c226coa c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
type: Species
has only substance units: false
is: C16169
initial amount: NaN
constant: false

metaR r0145
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.8.3.1
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is: SBO:0000176

metaR CERT1rt
modifier: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
is described by: ECO:0000304
reversible: true

metaR PPCDC
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110050#
is described by: ECO:0000269
name: phosphopantothenoylcysteine decarboxylase
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
reactant: MODEL1310110050#

metaR AG13T13g
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000

metaR FRDPtc
fast: false
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ

metaR DNDPt9m
is: SBO:0000185
is described by: ECO:0000269
reversible: false
product: MODEL1310110050#
fast: false
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dTDP antiport
modifier: MODEL1310110050#

metaR 10FTHF7GLUtm
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:mechanism is unknown IT
is: SBO:0000185
kinetic law: MODEL1310110050#
name: 7-glutamyl-10FTHF transport, mitochondrial
product: MODEL1310110050#
type: Reaction
reversible: false

metaM 4abut c
name: 4-Aminobutanoate
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
is: C00334
is: CHEBI:3628

metaM aacoa m
boundary condition: false
is: CHEBI:57286
initial concentration: 1.0
is: SBO:0000247
constant: false
name: acetoacetyl-CoA(4-)
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
has only substance units: false
is: HMDB01484

metaM leuktrE4 e
initial concentration: 1.0
is: CHEBI:57462
type: Species
is: HMDB02200
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false
name: leukotriene E4(1-)
is: SBO:0000247
boundary condition: false

metaR HCOUMARINte
kinetic law: MODEL1310110050#
name: xenobiotic transport
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110050#
fast: false
reversible: true
is: SBO:0000185

metaM crn c
is: SBO:0000247
initial concentration: 1.0
is: C00318
name: L-Carnitine
type: Species
constant: false
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false
boundary condition: false
is: CHEBI:16347
initial amount: NaN

metaM hs deg11 l
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
constant: false
initial concentration: 1.0
is: HMDB00868
is: CHEBI:57737
name: heparan sulfate, degradation product 11
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_e511fcbe_7358_4547_ba69_ea11ebf135f4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC25A16
has only substance units: false
is: P16260
boundary condition: true
is encoded by: hsa:8034
type: Species

metaM thf m
is: C00101
constant: false
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
type: Species
boundary condition: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
is: HMDB01846
is: CHEBI:57453
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_0c3e83e9_882c_4b0c_8981_d81fe142dbee
type: Species
initial amount: NaN
is encoded by: hsa:6575
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: B2RBR4
boundary condition: true
name: SLC20A2

metaM mescoa m
name: Mesaconyl-CoA
boundary condition: false
constant: false
is: C06028
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:27969

metaR THRGLYexR
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110050#
modifier: MODEL1310110050#
name: L-threonine/glycine reversible exchange

metaM ppi c
is: C00013
initial amount: NaN
is: CHEBI:0
name: Diphosphate
initial concentration: 1.0
is: HMDB00250
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_75912438_0026_43c9_919c_8fa214c290c4
is: B3KUK6
initial concentration: NaN
name: NT5C1B
is encoded by: hsa:93034
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r0156
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
product: MODEL1310110050#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is: SBO:0000176

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM dcamp c
constant: false
is: C03794
initial amount: NaN
boundary condition: false
name: N6-(1,2-Dicarboxyethyl)-AMP
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
type: Species
is: SBO:0000247
is: HMDB00536
initial concentration: 1.0
has only substance units: false
is: CHEBI:57567

metaR r1660
product: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110050#_fb08fbd2_a116_4a59_9c12_274fecd94d8d
is: P52824
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:1609
initial amount: NaN
name: DGKQ
is: SBO:0000252

metaR r2420
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaM dopasf e
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB06275
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:37946
name: dopamine 3-O-sulfate

metaR 4NPHte
is: SBO:0000185
reactant: MODEL1310110050#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110050#
is described by: ECO:0000000
name: xenobiotic transport
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_f187a38a_d15a_479c_a664_fbb2e5179f41
name: NT5C3
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51251
constant: false
is: SBO:0000252
has only substance units: false
is: Q9H0P0
type: Species

metaM gdp e
has only substance units: false
type: Species
is: CHEBI:58189
is: HMDB01201
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR SUBERICACT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR CHSTEROLt3
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: cholesterol intracellular transport
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110050#_5e55d699_4887_4cf9_a765_1163e2f42dab
is: SBO:0000252
is encoded by: hsa:AI926493
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: _AI926493_1_m
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_724cc3b4_4c76_424c_a049_09366b849441
is encoded by: hsa:10991
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q99624
name: SLC38A3
initial amount: NaN

metaM c10dc c
is: HMDB00651
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C17H30NO6 CHARGE: -1
has only substance units: false
boundary condition: false
name: sebacoyl carnitine
initial amount: NaN
constant: false
type: Species

metaM ddece1crn e
is: HMDB02250
constant: false
name: dodecenoyl carnitine
notes: FORMULA: C19H35NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r1661
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM ach e
constant: false
is: HMDB00895
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
is: SBO:0000247
is: CHEBI:15355
initial concentration: 1.0
type: Species
boundary condition: false
name: acetylcholine

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR BACCLm
reversible: false
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/6.3.4.10
fast: false
is: SBO:0000176
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reactant: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#

metaM gdpfuc g
constant: false
is: CHEBI:57984
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01095
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
name: GDP-L-fucose(2-)
is: SBO:0000247

metaM HC02208 c
initial amount: NaN
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
is: CHEBI:27696
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-d1
type: Species

metaR CHSTEROLt2
is: SBO:0000185
product: MODEL1310110050#
reactant: MODEL1310110050#
name: cholesterol intracellular transport
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR GLCNACASE1ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_f93c84c4_530c_49cf_a4d4_dabbe776f83f
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51733
name: UPB1
is: B3KNC1
boundary condition: true
constant: false

metaM ha pre1 l
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: hyaluronan biosynthesis, precursor 1
is: SBO:0000247
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_6c661c03_4251_43cf_be03_df32f27e3850
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6508
is: SBO:0000252
name: SLC4A3
initial amount: NaN
initial concentration: NaN
is: P48751
boundary condition: true

metaR SO4t4 2
name: sulfate transport via sodium symport
fast: false
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reactant: MODEL1310110050#
is described by: ECO:0000269

metaM fol c
notes: FORMULA: C19H18N7O6 CHARGE: -1
boundary condition: false
has only substance units: false
is: HMDB00121
initial amount: NaN
is: SBO:0000247
type: Species
name: Folate
constant: false
initial concentration: 1.0

metaR CHSTEROLt1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
is described by: ECO:0000304
modifier: MODEL1310110050#
fast: false
is: SBO:0000185
name: cholesterol intracellular transport
type: Reaction
reversible: true
reactant: MODEL1310110050#

metaM retinal r
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial amount: NaN
constant: false
is: CHEBI:15035
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: retinal
type: Species
is: HMDB01358

metaM gdp g
is: HMDB01201
type: Species
is: CHEBI:58189
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaM 10fthf l
is: HMDB00972
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57454
initial concentration: 1.0
name: 10-formyltetrahydrofolate(2-)

http://identifiers.org/biomodels.db/MODEL1310110050#_e099c531_f917_4da1_9b84_2f83afad4ad5
has only substance units: false
initial amount: NaN
is encoded by: hsa:9334
name: B4GALT5
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: O43286

metaR r0881
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110050#
reversible: false
name: Active transport
type: Reaction
fast: false
kinetic law: MODEL1310110050#

metaM debrisoquine e
type: Species
is: SBO:0000247
notes: FORMULA: C10H14N3 CHARGE: 1 INCHI: InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:34665
has only substance units: false
is: HMDB06543
constant: false
boundary condition: false
name: debrisoquine

http://identifiers.org/biomodels.db/MODEL1310110050#_ece52e50_ef3d_411e_9b63_b1133ba59900
has only substance units: false
constant: false
name: INPP4A
is encoded by: hsa:3631
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaR FCOAH
name: formyl coa hydrolase
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110050#
reversible: false

metaR DNDPt14m
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: false
name: dUDP transport via dTDP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110050#

metaM ach c
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
has only substance units: false
is: HMDB00895
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15355
type: Species
boundary condition: false
name: acetylcholine

metaM tsul c
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: HMDB00257
is: CHEBI:16094
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: thiosulfate(2-)

metaM 10fthf m
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
is: HMDB00972
constant: false
name: 10-formyltetrahydrofolate(2-)
is: CHEBI:57454
type: Species

metaR HMGLx
kinetic law: MODEL1310110050#
name: hydroxymethylglutaryl-CoA lyase
is version of: http://identifiers.org/ec-code/4.1.3.4
is described by: ECO:0000134
type: Reaction
product: MODEL1310110050#
fast: false
reversible: false
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
modifier: MODEL1310110050#

metaM HC02208 e
constant: false
is: CHEBI:27696
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: prostaglandin-d1
initial amount: NaN
type: Species

metaM gt1a hs c
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
boundary condition: false
is: CHEBI:27691
initial amount: NaN
is: SBO:0000247
constant: false
name: GT1a

metaR r1664
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_9f52d8b4_92ed_423c_b526_29cf9404a588
initial amount: NaN
name: GPX4
initial concentration: NaN
is: SBO:0000252
constant: false
is: P36969
has only substance units: false
is encoded by: hsa:2879
type: Species
boundary condition: true

metaR RE3568C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
name: RE3568
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_b962878c_d8e4_4e43_9379_69f6ac42f83a
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:51727
is: SBO:0000252
name: CMPK1
type: Species
is: B2R6S5
initial concentration: NaN

metaR RE0577C
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
name: RE0577
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110050#

metaR CERT2rt
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_18ed1bc5_d0ca_4711_9a3c_f58de3ab4eaf
has only substance units: false
constant: false
type: Species
is: Q9H310
is encoded by: hsa:57127
initial amount: NaN
boundary condition: true
name: RHBG
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_0f978fa2_7986_4292_a2d9_433da79ecb54
initial concentration: NaN
constant: false
has only substance units: false
name: CNDP1
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84735
is: Q96KN2
type: Species

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_0c97ce47_58e5_4290_a665_29ad6241c494
initial amount: NaN
is: SBO:0000252
name: FOLR1
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:2348

http://identifiers.org/biomodels.db/MODEL1310110050#_b1dbad37_9508_41ba_b820_cd50bb5ff6fb
is encoded by: hsa:6547
is: Q96QG2
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: SLC8A3
is: SBO:0000252

metaM bhb c
constant: false
is: HMDB00011
boundary condition: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
type: Species
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
is: SBO:0000247
initial amount: NaN

metaR r1396
name: EC:2.3.1.21
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction

metaR r1665
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR UMPKn
is: SBO:0000176
product: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110050#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110050#
name: UMP kinase, nuclear
modifier: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD

metaR PTE4x
product: MODEL1310110050#
is described by: ECO:0000269
modifier: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
name: peroxisomal acyl-CoA thioesterase
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110050#
is: SBO:0000176
reversible: false
reactant: MODEL1310110050#

metaR C141CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR VD3
name: Vitamin D3 formation
fast: false
type: Reaction
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
product: MODEL1310110050#

metaR S6T10g
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#

metaM lac L x
name: (S)-lactate
is: HMDB00190
is: CHEBI:16651
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaM gdpfuc c
is: CHEBI:57984
type: Species
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: GDP-L-fucose(2-)
is: HMDB01095
constant: false

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR r1662
product: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#

metaR PNTOte
reversible: true
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of (R)-Pantothenate
kinetic law: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
product: MODEL1310110050#

metaR r1397
type: Reaction
kinetic law: MODEL1310110050#
fast: false
reversible: false
product: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000176
name: carnitine acetyltransferase EC:2.3.1.7
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_96aee630_3351_49db_b3ea_8e2b7e0fff7b
is: SBO:0000252
constant: false
is encoded by: hsa:55568
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: GALNT10

http://identifiers.org/biomodels.db/MODEL1310110050#_37172068_da86_42e0_9b2e_7bd759ebdbb9
initial amount: NaN
name: NDUFS6
is: SBO:0000252
has only substance units: false
is: Q6IBC4
constant: false
is encoded by: hsa:4726
type: Species
boundary condition: true
initial concentration: NaN

metaM gdp c
type: Species
initial concentration: 1.0
is: SBO:0000247
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
has only substance units: false
is: HMDB01201
boundary condition: false
initial amount: NaN
is: CHEBI:58189
is: C00035

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR RE0453C
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true
kinetic law: MODEL1310110050#
name: RE0453
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_7ee0aefb_4ba2_4969_a0f1_d14969d223b6
type: Species
is: SBO:0000252
initial amount: NaN
is: Q6ZWT7
has only substance units: false
constant: false
name: MBOAT2
is encoded by: hsa:129642
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_fcf33d0e_87d1_43a4_baba_79acd2cf6dd9
boundary condition: true
is encoded by: hsa:6487
name: ST3GAL3
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM ump r
name: UMP
type: Species
is: HMDB00288
constant: false
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM bhb e
has only substance units: false
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
is: CHEBI:10983
initial concentration: 1.0
constant: false
name: (R)-3-hydroxybutyrate
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_e47f0494_c91a_48c6_8b59_89994fb28473
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:29880
constant: false
type: Species
boundary condition: true
is: Q9Y673
name: ALG5
has only substance units: false
initial amount: NaN

metaM ivcoa m
type: Species
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: HMDB01113
is: SBO:0000247
has only substance units: false
name: Isovaleryl-CoA
is: CHEBI:57345
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_285ce2f7_68ca_4cf2_b1b5_d4c9a714e5fa
name: PECR
type: Species
is encoded by: hsa:55825
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9BY49
constant: false
initial concentration: NaN

metaR r0885
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
type: Reaction
product: MODEL1310110050#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is version of: http://identifiers.org/ec-code/1.3.1.38

metaR C226CRNt
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
is: SBO:0000185
reversible: false
fast: false
name: C226 transport into the mitochondria
kinetic law: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_3164878c_69dd_4ba2_bd75_d7ea896efefc
name: PRDX1
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:5052
boundary condition: true
initial concentration: NaN

metaR DNDPt35m
reversible: false
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110050#
is: SBO:0000185
name: dGDP transport via dADP antiport
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

metaM 3aib m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
constant: false
type: Species
boundary condition: false
is: HMDB02166
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_3dec023f_819a_4dd3_92d9_f90d229459cc
type: Species
name: _LOC727762_1_m
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:LOC727762

http://identifiers.org/biomodels.db/MODEL1310110050#_eab4aa62_f4d5_42b2_b102_d9a77b7a49e4
boundary condition: true
name: HK1
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3098
is: P78542
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_600093a9_3245_400d_a38e_5f76a8bd8f7a
is encoded by: hsa:5151
constant: false
is: SBO:0000252
name: PDE8A
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR HMGLm
product: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.3.4
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
type: Reaction
fast: false
modifier: MODEL1310110050#
name: hydroxymethylglutaryl-CoA lyase
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176

metaR RE3243R
is: SBO:0000176
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
name: RE3243
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:

metaM HC01602 c
type: Species
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: CHEBI:21338
has only substance units: false
initial concentration: 1.0
is: HMDB02704
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](5)

metaR NBAHH ir
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
reversible: false
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.13.20
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_f4f800c4_c48b_4de6_bd9b_8f74d79c1a42
is encoded by: hsa:D87002
has only substance units: false
constant: false
initial amount: NaN
name: _D87002_1_m
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR GALGT2
modifier: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Beta-1,4 N-acetylgalactosaminyltransferase
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
fast: false
type: Reaction
kinetic law: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.92

http://identifiers.org/biomodels.db/MODEL1310110050#_5239844a_a6b2_482b_aea1_a05e4296e738
initial amount: NaN
has only substance units: false
is encoded by: hsa:8781
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: _8781_1_c
initial concentration: NaN

metaM orot e
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
is: HMDB00226
is: CHEBI:30839
has only substance units: false
constant: false
name: orotate
is: SBO:0000247
type: Species
boundary condition: false

metaR r1668
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110050#

metaM sbcoa x
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
has only substance units: false
constant: false
boundary condition: false
type: Species
name: suberylcoa
initial amount: NaN
initial concentration: 1.0
is: HMDB02014
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_442d9f47_e1e9_4558_bc5d_420b7442141e
is encoded by: hsa:54344
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8818
constant: false
type: Species
is: SBO:0000297
has part: Q9P2X0
initial concentration: NaN
name: DPM3:DPM1:DPM2

http://identifiers.org/biomodels.db/MODEL1310110050#_fee42853_1304_469f_9064_24ec263fa3c9
is encoded by: hsa:5831
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PYCR1
constant: false
is: A6NFM2

metaR 2HCO3 NAt
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
modifier: MODEL1310110050#
product: MODEL1310110050#
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
reactant: MODEL1310110050#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_e611ac71_aaa2_448c_a04b_feaa3dc9319f
name: HMGCL
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3155
is: Q6IBC0
type: Species
initial amount: NaN

metaM dhlpro m
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
constant: false
boundary condition: false
is: CHEBI:16194
is: SBO:0000247
name: Dihydrolipolprotein
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaM ivcoa c
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: Isovaleryl-CoA
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01113

http://identifiers.org/biomodels.db/MODEL1310110050#_5ba58fd1_8c38_496b_b923_940e8ccfb20c
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:BE042354
name: _BE042354_1_m

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR SUCCACT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR GALGT3
kinetic law: MODEL1310110050#
is described by: ECO:0000269
modifier: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.92
name: Beta-1,4 N-acetylgalactosaminyltransferase
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: false
type: Reaction

metaR r1669
reactant: MODEL1310110050#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r1774
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_33f93db1_c719_41b7_9c42_351d96b15760
initial concentration: NaN
name: ACSS2
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:55902
initial amount: NaN
is: Q5QPH3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_b9fa6ac0_b4b2_4b55_a61c_3499e5aa8463
constant: false
is encoded by: hsa:10246
is: O00624
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SLC17A2
type: Species
has only substance units: false

metaM ctp m
initial amount: NaN
name: CTP(4-)
constant: false
type: Species
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:37563
has only substance units: false

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM ump n
is: SBO:0000247
boundary condition: false
name: UMP(2-)
initial concentration: 1.0
is: HMDB00288
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
constant: false
initial amount: NaN
is: CHEBI:57865

metaR GALGT4
reversible: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
name: Beta-1,4 N-acetylgalactosaminyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.92

metaR DNDPt46m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
fast: false
modifier: MODEL1310110050#
product: MODEL1310110050#
reversible: false
name: dTTP transport via dUDP antiport
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000185

metaM orot c
is: CHEBI:30839
is: C00295
initial amount: NaN
constant: false
name: Orotate
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
initial concentration: 1.0
has only substance units: false

metaM gq1b hs g
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:7896
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
is: C00249
is: HMDB00220
name: GQ1b

http://identifiers.org/biomodels.db/MODEL1310110050#_715820bd_fdf8_44e9_bef1_034f42714931
constant: false
name: CHAT
is: D3DX95
is: SBO:0000252
is encoded by: hsa:1103
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaM tdcoa c
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
type: Species
is: CHEBI:57385
has only substance units: false
is: HMDB01521
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN

metaM ctp n
constant: false
is: CHEBI:37563
is: SBO:0000247
type: Species
is: HMDB00082
initial amount: NaN
has only substance units: false
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
boundary condition: false

metaR r1771
modifier: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#

metaR IDOAASE1ly
fast: false
name: alpha-L-iduronidase, lysosomal
modifier: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.76

metaR r1666
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR G5SADrm
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reversible: true
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110050#
is: SBO:0000176
fast: false
type: Reaction

metaR PYNP2r
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
is version of: http://identifiers.org/ec-code/2.4.2.3
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000176

metaM 10fthf e
type: Species
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00972
constant: false
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_13a40208_760b_4c59_919d_1bdd9ca3d77f
initial concentration: NaN
is: Q9NWW6
initial amount: NaN
is encoded by: hsa:54981
boundary condition: true
constant: false
is: SBO:0000252
name: NMRK1
type: Species
has only substance units: false

metaR r1667
name: Y+LAT2 Utilized transport
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_29a1dc6a_e0a1_4dc6_8232_c8c55024e472
initial concentration: NaN
is: Q9Y6T7
is encoded by: hsa:1607
name: DGKB
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_7b8eb880_0907_42c4_9a8c_9606e952460f
constant: false
boundary condition: true
name: _AI222095_1_m
is encoded by: hsa:AI222095
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_231fc8f2_be9e_4176_b713_6aab77fba98b
initial concentration: NaN
name: TKT
boundary condition: true
constant: false
is: E7EPA7
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7086

http://identifiers.org/biomodels.db/MODEL1310110050#_2bdea94e_0481_462a_a53f_5a57bcc26fca
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: COX7A2L
constant: false
is: Q6FGA0
type: Species
is encoded by: hsa:9167

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
reactant: MODEL1310110050#
type: Reaction

metaR ALADGLNexR
reversible: true
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
name: L-alanine/glutamine reversible exchange
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#

metaR CREATt4 2 r
kinetic law: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
type: Reaction
name: Creatine transport (sodium symport) (2:1)

metaM gq1b hs e
has only substance units: false
boundary condition: false
is: CHEBI:58115
is: SBO:0000247
is: HMDB01397
constant: false
type: Species
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
initial amount: NaN
name: GQ1b
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_4c681d71_240d_427b_b2cb_81f2209ad423
name: ACSL4
is encoded by: hsa:2182
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: O60488
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f61d5c0f_eab1_47bc_86ad_89c7563663f1
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:728441
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: GGT2

metaR DLNLCGCRNt
modifier: MODEL1310110050#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
product: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_5156267f_ea0e_435d_9645_37760f319718
is: SBO:0000252
initial amount: NaN
name: _AI684467_1_m
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AI684467

metaR RE0453M
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110050#
name: RE0453
modifier: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_486a91a6_371e_47e0_b130_11dc385a866e
name: SDHA:SDHB:SDHC:SDHD
constant: false
is encoded by: hsa:6392
is encoded by: hsa:6390
is: SBO:0000297
has part: Q99643
initial concentration: NaN
has part: P31040
has part: P21912
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
has part: O14521
is encoded by: hsa:6391
is encoded by: hsa:6389

http://identifiers.org/biomodels.db/MODEL1310110050#_91ee2bac_ffb8_4c5f_9df3_ad9151bd1e1e
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8705
is: B3KQP5
has only substance units: false
initial concentration: NaN
type: Species
name: B3GALT4
constant: false

metaM ump g
has only substance units: false
boundary condition: false
is: CHEBI:57865
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
name: UMP(2-)
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_2d81063d_cd12_4b99_b9aa_eb4402994983
name: NT5C
boundary condition: true
is: Q8TCD5
is encoded by: hsa:30833
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaM 10fthf c
type: Species
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
is: CHEBI:57454
is: SBO:0000247
name: 10-Formyltetrahydrofolate
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00234
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_da4e17b6_5059_41d3_8ae5_00485cbdc28d
is: SBO:0000252
name: _D29675_1_c
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:D29675
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_5d9a6c82_bf38_4981_8cfd_97ce908865be
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AL038231_1_c
constant: false
has only substance units: false
is encoded by: hsa:AL038231
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_21862ff7_2f08_4ad1_99a4_5aedb71090f1
initial concentration: NaN
is encoded by: hsa:9583
is: SBO:0000252
is: Q9Y227
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: ENTPD4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_f062e75e_e3f4_4962_868d_0e1d04b276de
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9990
type: Species
constant: false
has only substance units: false
is: Q9UHW9
name: SLC12A6

metaM 3aib c
initial amount: NaN
type: Species
is: CHEBI:33094
constant: false
is: SBO:0000247
has only substance units: false
name: (S)-3-aminoisobutyric acid
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: HMDB02166
initial concentration: 1.0
boundary condition: false

metaM betald m
type: Species
has only substance units: false
is: CHEBI:15710
is: HMDB01252
boundary condition: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
initial amount: NaN
initial concentration: 1.0
name: betaine aldehyde
is: SBO:0000247

metaR XYLTt
product: MODEL1310110050#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110050#
is: SBO:0000185
name: Xylitol transport via passive diffusion
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_f32d3218_52a6_4c52_be15_6fa3a043b53c
type: Species
is: E7EPT3
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:501
name: ALDH7A1
is: SBO:0000252

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR DNDPt25m
modifier: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110050#
is described by: ECO:0000269
name: dTDP transport via dCDP antiport
type: Reaction
kinetic law: MODEL1310110050#
fast: false
reversible: false
is: SBO:0000185

metaR FRDPtr
name: lipid, flip-flop intracellular transport
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
product: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_5b9e36ad_545f_45c4_a6aa_2b2d41183059
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: ECI1
is: P42126
constant: false
is encoded by: hsa:1632
initial concentration: NaN

metaM psyl e
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/79101
type: Species
is: HMDB00721
has only substance units: false
name: psyllium
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false

metaM gq1b hs c
constant: false
initial concentration: 1.0
is: CHEBI:7896
has only substance units: false
name: GQ1b
initial amount: NaN
boundary condition: false
is: C00249
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
is: SBO:0000247
is: HMDB00220
type: Species

metaR AICARte
fast: false
reversible: true
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

metaR FAOXC4C4DCc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_308a4bca_847e_45a6_828c_a21768271275
name: KHK
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q6IBK2
type: Species
is encoded by: hsa:3795
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_ee68c436_8b40_4500_b3cb_afb63adc0738
name: _AI285872_1_c
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:AI285872
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM q10h2 m
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: HMDB13111
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: http://identifiers.org/pubchem.compound/6504740

metaM 3aib e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02166
constant: false
name: (S)-3-aminoisobutyric acid
is: CHEBI:33094
type: Species
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaR SMPD4
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110050#
name: sphingomyelinase

metaR r0527
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
fast: false

metaM ddece1crn c
name: dodecenoyl carnitine
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB03712
notes: FORMULA: C19H35NO4 CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

metaM C05279 m
initial amount: NaN
name: trans,cis-Lauro-2,6-dienoyl-CoA
constant: false
is: CHEBI:28387
is: HMDB11123
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_06908e3d_44e9_4faa_bcb0_1058d303acf5
is: B4DK61
boundary condition: true
is: SBO:0000252
name: ACOX1
constant: false
initial amount: NaN
is encoded by: hsa:51
initial concentration: NaN
type: Species
has only substance units: false

metaR FUMTSULtm
modifier: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
type: Reaction
name: Fumarate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_27bb70b2_1d64_4123_8fc9_03b326874cec
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _NM_001929_1_c
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:NM 001929

metaR FAS160COA
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
reversible: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
type: Reaction
fast: false
name: fatty-acyl-CoA synthase (n-C16:0CoA)
kinetic law: MODEL1310110050#
product: MODEL1310110050#

metaM retinol 9 cis e
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:17336
has only substance units: false
name: 9-cis-retinol
is: HMDB06217
type: Species
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false

metaR CYSO
is: SBO:0000176
reactant: MODEL1310110050#
name: cysteine oxidase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is version of: http://identifiers.org/ec-code/1.13.11.20
modifier: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_3e0b85dc_20ce_486b_b4a7_9c79313bdaa8
name: _AA278423_1_m
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:AA278423
initial concentration: NaN

metaM gdpddman c
initial amount: NaN
boundary condition: false
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial concentration: 1.0
is: HMDB01346
is: CHEBI:57964
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
has only substance units: false

metaR NDPK5n
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
modifier: MODEL1310110050#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reversible: true
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_f248c7e5_7df5_4dfe_9813_d4419e051419
name: DEGS1
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:8560
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_8537c537_7626_459b_be45_b2fc63d39f95
initial amount: NaN
type: Species
boundary condition: true
name: PIK3R1
initial concentration: NaN
is: P27986
constant: false
is encoded by: hsa:5295
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_9bc8f7e2_2aae_4577_aef2_9b7cb4a32f83
is: SBO:0000252
is: Q9Y217
is encoded by: hsa:9107
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: MTMR6
boundary condition: true

metaM mlthf m
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN
is: CHEBI:15636
constant: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01533
type: Species
is: C00143

metaR r0556
kinetic law: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false

metaM cs a deg2 l
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2

metaR FE2DMT1
notes: GENE_ASSOCIATION: (4891.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
name: uptake of food iron by DMT1 transporter
fast: false

metaM retinol 9 cis c
has only substance units: false
is: HMDB06217
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: 9-cis-retinol
is: CHEBI:17336
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
constant: false

metaR O2St
name: superoxide anion transport via diffusion (extracellular)
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
type: Reaction
reversible: true

metaM b2coa m
name: crotonoyl-CoA(4-)
is: CHEBI:57332
type: Species
has only substance units: false
is: HMDB02009
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877

http://identifiers.org/biomodels.db/MODEL1310110050#_c77a7078_0c78_4662_bc8d_4e763b96d088
boundary condition: true
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
is: SBO:0000297
is encoded by: hsa:4967
initial amount: NaN
has only substance units: false
type: Species
has part: B4E3E9
constant: false

metaR r0553
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

http://identifiers.org/biomodels.db/MODEL1310110050#_e3084778_b30b_4012_b2a9_86ca225e3c76
is encoded by: hsa:23530
is: SBO:0000252
constant: false
type: Species
name: NNT
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q13423

metaM rnam c
constant: false
boundary condition: false
name: N-Ribosylnicotinamide
has only substance units: false
is: HMDB00855
is: CHEBI:15927
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_3be08345_e594_40fd_a9e8_ffb8a789f3f2
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: DHCR7
has only substance units: false
boundary condition: true
is: Q9UBM7
initial concentration: NaN
is encoded by: hsa:1717

metaR ARACHDtr
type: Reaction
reactant: MODEL1310110050#
fast: false
reversible: true
is described by: ECO:0000000
name: intracellular transport
kinetic law: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR RE1233C
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
name: RE1233
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
product: MODEL1310110050#

metaR G14T11g
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3f38ec16_76dc_4e7d_b3c8_80b1164da4ae
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: FUT8
constant: false
has only substance units: false
is encoded by: hsa:2530
initial amount: NaN
is: Q9BYC5
type: Species

metaM ga1 hs g
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58524
initial concentration: 1.0
initial amount: NaN
name: gibberellin A1(1-)
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0 INCHI: InChI=1S/C19H24O6/c1-9-7-17-8-18(9,24)5-3-10(17)19-6-4-11(20)16(2,15(23)25-19)13(19)12(17)14(21)22/h10-13,20,24H,1,3-8H2,2H3,(H,21,22)/p-1/t10-,11+,12-,13-,16-,17+,18+,19-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110050#_7ec86ad9_141f_4f49_a08f_0f673a4d1dd3
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10637
name: LEFTY1
type: Species
is: O75610
initial concentration: NaN
is: SBO:0000252
constant: false

metaR SUCOAS1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
fast: false
is: SBO:0000176
name: Succinate--CoA ligase (GDP-forming)
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.4

metaM dgmp m
initial concentration: 1.0
boundary condition: false
name: dGMP
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: C00362
is: CHEBI:57673
is: HMDB01044
type: Species

metaM asp L e
has only substance units: false
constant: false
is: CHEBI:29991
is: HMDB00191
is: SBO:0000247
initial amount: NaN
name: L-aspartate(1-)
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_7e7d98e9_4f35_46a6_9617_f36f01324ea7
is encoded by: hsa:4698
is: SBO:0000252
type: Species
boundary condition: true
name: NDUFA5
initial concentration: NaN
initial amount: NaN
constant: false
is: Q16718
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3caa92ae_dc9b_44c1_8e1f_99cf8f8db146
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:642502
name: _642502_1_c

http://identifiers.org/biomodels.db/MODEL1310110050#_63ab86a2_6db7_4343_86df_c0d2f14a0487
initial concentration: NaN
boundary condition: true
is encoded by: hsa:84720
type: Species
has only substance units: false
name: PIGO
is: SBO:0000252
initial amount: NaN
constant: false

metaR r0559
kinetic law: MODEL1310110050#
fast: false
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110050#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
product: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR r1639
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
is: SBO:0000185
modifier: MODEL1310110050#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110050#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FAOXC5OHc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_848bd279_2007_4028_89fd_5e34dfb33d06
has only substance units: false
constant: false
name: LHPP
is encoded by: hsa:64077
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9H008

http://identifiers.org/biomodels.db/MODEL1310110050#_9eea0bd9_f5e9_430e_b59b_5215cfd253ab
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: P23378
is encoded by: hsa:2731
initial amount: NaN
boundary condition: true
has only substance units: false
name: GLDC

metaM ethamp c
name: ethamp[c]
is: HMDB00224
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false

metaM 3spyr c
is: HMDB04045
initial concentration: 1.0
name: 3-sulfonatopyruvate(2-)
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:57940
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_49332511_9bdb_4284_b825_8c3ec66a81c8
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: _AV727634_1_c
initial amount: NaN
is encoded by: hsa:AV727634

metaM dtdp c
initial concentration: 1.0
is: HMDB01274
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
initial amount: NaN
is: CHEBI:58369
is: C00363
is: SBO:0000247
name: dTDP
type: Species
boundary condition: false

metaM HC02187 c
boundary condition: false
is: CHEBI:28774
is: SBO:0000247
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR PPItr
is: SBO:0000185
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
name: Diphosphate transporter, endoplasmic reticulum
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110050#

metaM leu L m
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: L-leucine
is: HMDB00687
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_9403a198_b094_4cd6_9681_5eec326c9ff5
name: LDHAL6B
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:92483
is: Q9BYZ2

metaR LYSOXp
reactant: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
product: MODEL1310110050#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110050#
name: L-lysine oxidase, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110050#_c4b65eb2_2ff0_43ce_8a8f_783fabd279c4
name: AMY1A
is encoded by: hsa:276
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: Q6NSB3

http://identifiers.org/biomodels.db/MODEL1310110050#_0dc6f67c_fd4a_481f_b420_7e01e930f85d
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: _LOC647190_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:LOC647190
initial concentration: NaN

metaR r1638
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110050#
fast: false

metaR Ser Thrtg
product: MODEL1310110050#
fast: false
name: Ser/Thr transport (from golgi to lysosome)
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is described by: ECO:0000269
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_c45645af_f147_4f85_b366_82c8202cd769
initial concentration: NaN
constant: false
boundary condition: true
name: CYP27A1
is encoded by: hsa:1593
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q02318

http://identifiers.org/biomodels.db/MODEL1310110050#_e737a20e_0199_450f_a791_9aca748f3ed2
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:AA081045
is: SBO:0000252
name: _AA081045_1_m
boundary condition: true
initial concentration: NaN

metaM mi3p D c
constant: false
initial concentration: 1.0
is: HMDB06814
boundary condition: false
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
is: SBO:0000247
type: Species
name: 1D-myo-inositol 3-phosphate(2-)
initial amount: NaN
is: CHEBI:58401

metaR BHBt
fast: false
is described by: ECO:0000000
product: MODEL1310110050#
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV

metaR r1790
product: MODEL1310110050#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185

metaR r1936
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110050#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_2e3846a0_b52c_4741_b8eb_5ff23c0e8632
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7371
type: Species
boundary condition: true
constant: false
name: UCK2
is: SBO:0000252
initial amount: NaN
is: Q9BZX2

metaM dtdp e
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58369
has only substance units: false
is: HMDB01274

metaM gam6p c
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
constant: false
is: CHEBI:12962
name: D-Glucosamine 6-phosphate
type: Species
is: HMDB01254
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM HC02187 e
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial concentration: 1.0
is: CHEBI:28774

metaR ACNMLr
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
name: N-Acetylneuraminate lyase (reversible)
reversible: true
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR

metaR r0558
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110050#
fast: false

metaM glyald c
is: C00577
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: D-Glyceraldehyde
is: HMDB01051
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0
boundary condition: false
is: CHEBI:17378

http://identifiers.org/biomodels.db/MODEL1310110050#_88f05986_cca0_416e_bea7_d0cc5a4d7d6e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1103
type: Species
initial concentration: NaN
is: Q6LEN6
has only substance units: false
initial amount: NaN
name: CHAT
constant: false

metaM itp e
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
initial amount: NaN
name: ITP(3-)
constant: false
is: HMDB00189
initial concentration: 1.0

metaM prostge2 e
is: CHEBI:606564
is: SBO:0000247
type: Species
name: prostaglandin E2(1-)
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
is: HMDB01220
initial concentration: 1.0

metaR DURItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
type: Reaction
reversible: true
name: deoxyuridine transport in nucleus
product: MODEL1310110050#
kinetic law: MODEL1310110050#

metaM prpp c
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB00280
is: CHEBI:58017
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate

metaM gt1a hs g
is: CHEBI:27691
initial concentration: 1.0
name: GT1a
boundary condition: false
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

metaR TRIODTHYt2
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
modifier: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
name: T3 transport via facilitated diffusion
reversible: true

metaR LINKDEG3ly
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110050#
is: SBO:0000176
fast: false
reversible: false
type: Reaction

metaR PUNP3
modifier: MODEL1310110050#
name: purine-nucleoside phosphorylase (Guanosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
is: SBO:0000176
fast: false

metaM formcoa c
has only substance units: false
is: SBO:0000247
is: CHEBI:57376
constant: false
initial amount: NaN
is: HMDB03419
name: formyl-CoA(4-)
type: Species
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
initial concentration: 1.0
boundary condition: false

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM gchola c
name: glycocholate
boundary condition: false
is: CHEBI:58235
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: HMDB00138
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_eaab916d_ac88_4fd7_b579_a8954ff61c8e
type: Species
is: Q15125
initial amount: NaN
is encoded by: hsa:10682
has only substance units: false
name: EBP
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_49851a7a_7a79_49d3_861b_f95e1bd14872
initial amount: NaN
is encoded by: hsa:517
name: ATP5G2
constant: false
is: Q06055
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_77e50eca_fb6d_4be8_8f63_0d21e9b1a867
constant: false
name: _PRO1933_1_m
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:PRO1933
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_c839e722_1aff_42e3_af4b_36f3b8b04b39
initial amount: NaN
is encoded by: hsa:7378
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: UPP1
is: SBO:0000252

metaR RE2659R
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
type: Reaction
name: RE2659
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true

metaR PUNP2
type: Reaction
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110050#
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is described by: ECO:0000269
modifier: MODEL1310110050#
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110050#

metaR CSEPASEly
reversible: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#

metaR ALR2
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.21
name: aldose reductase (methylglyoxal)
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaR C226CPT2
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
fast: false
name: C226 transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110050#_e0422e47_da7c_4d91_be07_c75005892d0f
is: P04075
constant: false
type: Species
is encoded by: hsa:226
boundary condition: true
name: ALDOA
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM CE5160 r
name: 3-oxo-cis-9-octadecenoyl-CoA
is: CHEBI:57923
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
is: SBO:0000247
boundary condition: false

metaR RE1804M
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: RE1804
fast: false
type: Reaction

metaM alpro m
name: S-Aminomethyldihydrolipoylprotein
initial amount: NaN
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
boundary condition: false
constant: false
is: CHEBI:16882
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaM itp c
constant: false
is: HMDB00189
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
is: SBO:0000247
name: ITP(3-)
is: CHEBI:57614
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r0400
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:

metaR NCCt
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (6559.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739168,PMID:8528245,PMID:8670281,PMID:8812482 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
name: Na+-Cl- cotransport
reactant: MODEL1310110050#
reversible: false
type: Reaction
modifier: MODEL1310110050#

metaM l2fn2m2masn g
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial amount: NaN
notes: FORMULA: C68H113N4O49X CHARGE: 0
boundary condition: false

metaR ASPPROASCT1
reversible: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
name: aspartate intake by system ASCT-1 transporter
is: SBO:0000185
reactant: MODEL1310110050#
fast: false
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000134

metaM pser L c
initial amount: NaN
is: CHEBI:15811
constant: false
name: O-Phospho-L-serine
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
type: Species
has only substance units: false
is: HMDB01721
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM gd1a hs g
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
boundary condition: false
constant: false
is: CHEBI:58397
name: N-acetylneuraminosyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminosyl)-D-galactosyl-D-glucosylceramide dianion
is: SBO:0000247

metaR BMTer L
name: B mannosyltransferase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110050#
fast: false

metaR C226CPT1
reactant: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
name: carnitine C22:6 transferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110050#
reversible: false
fast: false

metaR PPDOy
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM gt1a hs e
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
initial concentration: 1.0
constant: false
is: CHEBI:27691
boundary condition: false
initial amount: NaN
name: GT1a

http://identifiers.org/biomodels.db/MODEL1310110050#_7efd0809_d2f0_4603_8ae1_139bf72f6018
has only substance units: false
type: Species
is: Q9Y2B2
is encoded by: hsa:9487
initial concentration: NaN
boundary condition: true
name: PIGL
is: SBO:0000252
initial amount: NaN
constant: false

metaR PUNP4
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is: SBO:0000176
is described by: ECO:0000269

metaM gchola e
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0
name: glycocholate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: HMDB00138

metaR ACGPID
reversible: false
type: Reaction
is described by: ECO:0000269
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is: SBO:0000176
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.5.1.89
modifier: MODEL1310110050#

metaR RE1522M
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
modifier: MODEL1310110050#
is: SBO:0000176
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1522
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR THCHOLSTOICtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110050#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
name: lipid, flip-flop intracellular transport
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_5c86f0bd_3341_46f6_912e_d3f1479a3063
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:27068
initial amount: NaN
type: Species
name: PPA2
initial concentration: NaN

metaM asp L m
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
is: HMDB00191
is: CHEBI:29991
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: L-aspartate(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_6acb19c5_9f92_41d8_8ab5_af61d191b231
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ACSS1
is: SBO:0000252
is encoded by: hsa:84532
is: Q9NUB1
initial concentration: NaN

metaM ksi pre10 g
is: CHEBI:2504
initial concentration: 1.0
type: Species
constant: false
is: HMDB06552
boundary condition: false
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 10
has only substance units: false

metaR IDOAASE2ly
modifier: MODEL1310110050#
product: MODEL1310110050#
name: alpha-L-iduronidase, lysosomal
reversible: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

metaR ALAR
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#
name: alanine racemase
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110050#

metaR r2508
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
name: Utilized transport
kinetic law: MODEL1310110050#
is described by: ECO:0000000

metaR TAGt
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
name: triacylglycerol transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_f200d2b2_d579_43a8_a9d4_93ed8c321a19
name: EHHADH
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:1962
has only substance units: false
initial amount: NaN
is: Q9NY65
constant: false
boundary condition: true

metaR ALAALAPEPT1tc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Alanylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR PI45P4P
is: SBO:0000176
reversible: false
reactant: MODEL1310110050#
fast: false
type: Reaction
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
is described by: ECO:0000000
kinetic law: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD

metaR PUNP6
name: purine-nucleoside phosphorylase (Deoxyinosine)
type: Reaction
fast: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110050#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110050#
product: MODEL1310110050#

metaR r0552
product: MODEL1310110050#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
modifier: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000176
reversible: true
reactant: MODEL1310110050#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is version of: http://identifiers.org/ec-code/1.3.5.1

metaM CE1617 r
is: HMDB01358
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
is: SBO:0000247
type: Species
name: 9-cis-retinoate
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17898

metaR 5FTHFt2
reversible: true
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES:IT
product: MODEL1310110050#
modifier: MODEL1310110050#
name: 5-formyltetrahydrofolate transport via anion exchange
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269

metaR RE1520M
reactant: MODEL1310110050#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1520

metaM glyald m
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
initial amount: NaN
is: HMDB01051
initial concentration: 1.0
constant: false
type: Species
name: D-glyceraldehyde

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM dhor S c
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB03349
is: CHEBI:30864
type: Species
is: SBO:0000247
name: (S)-dihydroorotate
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_84c70127_50cf_4b98_b3a0_7d3b7c26ccf1
initial amount: NaN
is encoded by: hsa:LOC374569
is: SBO:0000252
type: Species
name: _LOC374569_1_e
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_39ddc4b9_80e2_4c74_9c62_55c049edc68f
is: SBO:0000252
boundary condition: true
name: HMBS
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3145
initial amount: NaN
is: P08397

metaR DUTPDPn
is: SBO:0000176
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.6.1.23
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
name: dUTP diphosphatase, nuclear

http://identifiers.org/biomodels.db/MODEL1310110050#_a8f4032a_a51b_422d_bdee_e0f4bc05a708
boundary condition: true
initial concentration: NaN
has part: P08195
is encoded by: hsa:56301
is: SBO:0000297
has part: Q9NS82
has only substance units: false
initial amount: NaN
is encoded by: hsa:6520
name: SLC7A10:SLC3A2
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_d4c0721b_51fb_43f5_a418_7d28c6a3e180
is: SBO:0000252
is encoded by: hsa:2592
type: Species
initial amount: NaN
has only substance units: false
name: GALT
is: B4E097
initial concentration: NaN
constant: false
boundary condition: true

metaR r0139
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.2.2
fast: false
reversible: true
modifier: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#

metaR BTNDm
reactant: MODEL1310110050#
fast: false
name: biotinidase (biotin), mitochondrial
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.5.1.12
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is described by: ECO:0000269
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false

metaM prpp e
is: HMDB00280
has only substance units: false
is: CHEBI:58017
is: SBO:0000247
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
constant: false
initial amount: NaN

metaR r2506
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110050#
name: Utilized transport
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_10f3ded8_d973_4b17_9cf5_2f8a29ae38fe
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2530
boundary condition: true
name: FUT8
is: G3V5N0
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

metaM dctp c
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00998
is: CHEBI:16311
is: SBO:0000247
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458

metaR PPItm
fast: false
product: MODEL1310110050#
name: diphopshate transporter, mitochondrial
type: Reaction
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is: SBO:0000185
is described by: ECO:0000134
reversible: true

metaM gluala e
initial concentration: 1.0
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
type: Species
is: http://identifiers.org/pubchem.compound/6503
constant: false
boundary condition: false
is: C03740
is: SBO:0000247
initial amount: NaN
name: 5-L-Glutamyl-L-alanine
has only substance units: false
is: HMDB06248

http://identifiers.org/biomodels.db/MODEL1310110050#_7ce750ce_e493_4bd3_a507_a98b8288a0b0
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: O00750
name: PIK3C2B
initial concentration: NaN
constant: false
is encoded by: hsa:5287

metaR RE3079X
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
fast: false
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
product: MODEL1310110050#
name: RE3079
reversible: true

metaR CHLPCTD
fast: false
name: choline phosphate cytididyltransferase
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.15
modifier: MODEL1310110050#
reversible: false
is described by: ECO:0000269
product: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_da18c837_612f_4421_9337_d605c5196483
initial concentration: NaN
is: B3KN25
is: SBO:0000252
name: CEPT1
is encoded by: hsa:10390
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_91cb2920_17c7_4aa7_a929_a43ad3744500
initial concentration: NaN
boundary condition: true
name: CHST3
is: Q7LGC8
is encoded by: hsa:9469
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM dmhptcoa m
has only substance units: false
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
is: HMDB06258
type: Species
name: 2,6 dimethylheptanoyl-CoA
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR ASPNATm
reactant: MODEL1310110050#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
fast: false
name: aspartate N-acetyltransferase, mitochondrial
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_ef0baecf_6977_4e98_8595_9b1fce1c9886
is encoded by: hsa:5860
boundary condition: true
initial amount: NaN
name: QDPR
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: P09417

http://identifiers.org/biomodels.db/MODEL1310110050#_a7e947b3_81ee_4dc4_89c1_f3b1a933de52
is encoded by: hsa:285973
boundary condition: true
constant: false
name: ATG9B
has only substance units: false
is: Q674R7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_fdb99f72_d6c3_4b6e_9e12_4ca11d41b8e4
type: Species
initial concentration: NaN
is encoded by: hsa:79087
name: ALG12
initial amount: NaN
boundary condition: true
is: Q9BV10
has only substance units: false
constant: false
is: SBO:0000252

metaM thr L c
name: L-threonine
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00167
constant: false
is: CHEBI:16857
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN

metaM 2mpdhl m
constant: false
has only substance units: false
initial concentration: 1.0
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: SBO:0000247
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
initial amount: NaN
boundary condition: false
is: CHEBI:17577
type: Species

metaM HC01609 e
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: UroporphyrinogenI
is: CHEBI:28766
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766

metaR RE3242R
kinetic law: MODEL1310110050#
reversible: true
fast: false
name: RE3242
is: SBO:0000176
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#

metaM thymd m
is: C00214
is: SBO:0000247
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
constant: false
is: HMDB00273
name: Thymidine
has only substance units: false
is: CHEBI:17748
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_6fa110e5_32a4_4e6f_838d_aa7b09bb5ab6
name: PDE7A
boundary condition: true
has only substance units: false
is: Q13946
is: SBO:0000252
constant: false
is encoded by: hsa:5150
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_af3219a7_d03b_4e4b_a189_283966424023
is: SBO:0000252
is encoded by: hsa:8706
boundary condition: true
is: O75752
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: B3GALNT1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_700cbd05_5c70_49c2_a890_eb6f46e04453
is encoded by: hsa:956
boundary condition: true
has only substance units: false
type: Species
is: O75355
name: ENTPD3
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_f419330b_6045_46d1_b2f6_f182e54b37b9
boundary condition: true
type: Species
name: VNN3:VNN2:VNN1
has part: O95498
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8875
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110050#_928f7918_c869_4c3f_be20_e8650cde9b58
is: P28329
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1103
name: CHAT
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_43215e26_ce7c_4dcf_97ba_5861ee304dca
is: Q16720
has only substance units: false
name: ATP2B3
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:492
type: Species
is: SBO:0000252

metaR RE3567C
type: Reaction
fast: false
reactant: MODEL1310110050#
name: RE3567
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true

metaM 42A3HP24DB c
is: C05645
is: HMDB04083
type: Species
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: SBO:0000247
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/7956

metaR 2MB2COAc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaM hs deg2 l
has only substance units: false
name: heparan sulfate, degradation product 2
is: SBO:0000247
is: HMDB06254
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
type: Species
initial concentration: 1.0

metaM ksi pre9 g
type: Species
is: SBO:0000247
is: HMDB06552
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
initial concentration: 1.0
is: CHEBI:2504
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 9
constant: false
initial amount: NaN
boundary condition: false

metaR CMPACNAtg
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
product: MODEL1310110050#
name: CMP-Sia Golgi transport via CMP antiport
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_b47dfcf4_0afd_4024_936b_f8de9d7e0f94
has only substance units: false
name: ALG8
initial amount: NaN
is encoded by: hsa:79053
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_8a79efbd_80d5_4ad4_92a5_f6950b8dbb41
is: P09917
initial concentration: NaN
is encoded by: hsa:240
name: ALOX5
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_89c9f95a_1fcd_42e0_89f8_d701ab330282
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ALDH3A1
type: Species
constant: false
is: P30838
boundary condition: true
has only substance units: false
is encoded by: hsa:218

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM crn m
is: HMDB00062
is: C00318
type: Species
is: SBO:0000247
boundary condition: false
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16347

metaR MI145PK
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
name: inositol-1,4,5-trisphosphate 3-kinase
kinetic law: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.127
modifier: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#

metaM 4mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00695
constant: false
is: CHEBI:17865
boundary condition: false

metaM 44mctr r
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: HMDB01023
type: Species
constant: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false
is: CHEBI:17813

metaM ksi pre18 g
name: keratan sulfate I biosynthesis, precursor 18
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
boundary condition: false
is: HMDB06552
type: Species
is: CHEBI:2504
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_94184ace_3b04_4f42_9a3c_56f174687eaf
is: SBO:0000252
constant: false
initial amount: NaN
is: P52790
is encoded by: hsa:3101
has only substance units: false
boundary condition: true
name: HK3
type: Species
initial concentration: NaN

metaR EX alaala LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for alanylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_8ee0741a_f266_4e0c_9294_8cd87b03ed45
is: O14521
is encoded by: hsa:6392
type: Species
name: SDHD
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3916b67d_096b_420a_9f92_83d5b7e2a487
name: SLCO2A1
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:6578
is: Q92959

http://identifiers.org/biomodels.db/MODEL1310110050#_ad55da3e_c5db_45bf_a5e7_8dcae68bc486
has only substance units: false
is encoded by: hsa:56301
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC7A10
is: Q9NS82
boundary condition: true
initial amount: NaN
type: Species

metaR r2509
reactant: MODEL1310110050#
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110050#
reversible: true
product: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM glcur l
initial concentration: 1.0
name: D-glucuronate
initial amount: NaN
is: HMDB00127
is: CHEBI:15748
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_253f5123_a996_40fc_b7f1_823c0d51423b
boundary condition: true
type: Species
is: SBO:0000252
name: PIGH
is encoded by: hsa:5283
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q14442

metaM leu L c
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00687
is: SBO:0000247
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
boundary condition: false
name: L-leucine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_412b7594_4759_45ad_85cf_36b4e89cd1ed
has only substance units: false
is encoded by: hsa:2271
boundary condition: true
is: SBO:0000252
name: FH
initial concentration: NaN
is: P07954
initial amount: NaN
type: Species
constant: false

MODEL1310110050#
species: metaM glyc S e
species: metaM urcan c
species: metaM gullac c
species: metaM dgdp c
species: metaM pail45p hs c
species: metaM ppi e
species: metaM ksi pre6 g
species: metaM adrncoa m
species: metaM ivcoa m
species: metaM mn l
species: metaM sphmyln hs g
species: metaM c3dc c
species: metaM 44mzym r
stoichiometry: 1.5
species: metaM prist x
stoichiometry: 0.039036
species: metaM hs deg14 l
species: metaM uacgam c
species: metaM 3hpp m
species: metaM HC00822 l
species: metaM 3php c
species: metaM debrisoquine c
species: metaM thym e
species: metaM 5aizc c
species: metaM 25aics c
species: metaM 34hpp c
species: metaM dump m
species: metaM retinol c
species: metaM ncam e
species: metaM cit e
species: metaM coa e
species: metaM 56dura c
species: metaM pdx5p c
stoichiometry: 0.259466
species: metaM CE2866 c
species: metaM hom L c
species: metaM cdp n
species: metaM frdp r
species: metaM crvnc c
species: metaM ppcoa m
value: -1.0
species: metaM udp n
species: metaM m2gacpail hs r
species: metaM thymd c
species: metaM bilglcur r
species: metaM thp2c x
species: metaM dtmp e
species: metaM drib e
species: metaM bilirub e
species: metaM air c
species: metaM bilglcur e
species: metaM mgacpail hs r
species: metaM dlnlcgcoa c
species: metaM 10fthf l
species: metaM dutp n
species: metaM cspg d e
species: metaM atp r
species: metaM tdchola e
species: metaM alaala c
species: metaM nh4 n
stoichiometry: 0.020401
species: metaM 5mthf e
species: metaM hs deg20 l
species: metaM ach e
species: metaM ppi x
species: metaM m2mn l
species: metaM 4mop c
species: metaM glypro c
species: metaM ethamp c
species: metaM homoval m
species: metaM tdcoa m
species: metaM ddece1crn c
stoichiometry: 0.013183
species: metaM ptth c
species: metaM dttp e
species: metaM 34dhpha c
species: metaM 6a2ohxnt x
species: metaM glyc R c
species: metaM arachd l
species: metaM Tn antigen l

http://identifiers.org/biomodels.db/MODEL1310110050#_8426bb17_ec0b_4f35_91c6_164c415722b0
name: DPYD
is encoded by: hsa:1806
boundary condition: true
has only substance units: false
constant: false
is: Q12882
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM prostgh2 e
initial amount: NaN
is: HMDB01381
is: CHEBI:57405
initial concentration: 1.0
name: prostaglandin H2(1-)
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_df9b6ee2_e7fb_4889_9d07_d08ee3ae6b69
is encoded by: hsa:57835
name: SLC4A5
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_7f16113f_8d2f_4be3_be79_01fdc66fd939
constant: false
is: P30838
type: Species
is encoded by: hsa:218
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: ALDH3A1

http://identifiers.org/biomodels.db/MODEL1310110050#_72169e74_9bea_475f_bf98_9e96b81de454
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: _W74642_1_c
is encoded by: hsa:W74642
boundary condition: true
type: Species
constant: false
is: SBO:0000252

metaR r0899
is: SBO:0000185
reversible: true
reactant: MODEL1310110050#
is described by: ECO:0000000
fast: false
name: Amino acid transporter ATB0+ Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction

metaR r0408
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110050#
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_aea03c2e_bede_4cc9_8f56_f70e162a6ebc
constant: false
name: SLC6A2
initial amount: NaN
is: SBO:0000252
is: Q96KH8
is encoded by: hsa:6530
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaM 6a2ohxnt x
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17534
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 6-amino-2-oxohexanoic acid
is: HMDB12151
constant: false

metaR r0142
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
reversible: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
product: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR r0407
type: Reaction
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reversible: true

metaR PSERT
is described by: ECO:0000269
product: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.52
is: SBO:0000176
name: phosphoserine transaminase
kinetic law: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110050#_a5ae9fad_d3b3_461a_94c8_3a8236ed17a8
name: NME7
is encoded by: hsa:29922
has only substance units: false
initial amount: NaN
constant: false
is: Q9Y5B8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r0892
is: SBO:0000185
type: Reaction
name: Facilitated diffusion
product: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.27
reversible: true
reactant: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
fast: false
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_c78b2495_5859_4786_93cf_a7c4a5bdcad6
name: SLCO4A1
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:28231
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: Q96BD0

metaM c3dc c
constant: false
initial concentration: 1.0
boundary condition: false
name: malonyl carnitine
is: HMDB02095
notes: FORMULA: C10H16NO6 CHARGE: -1
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

metaM na1 e
boundary condition: false
constant: false
notes: FORMULA: Na CHARGE: 1
initial concentration: 1.0
is: C01330
has only substance units: false
type: Species
is: CHEBI:4541
name: Sodium
is: HMDB00588
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_9fa7fd7c_d643_4cba_9837_0bc899e98dee
is: Q9Y672
type: Species
has only substance units: false
is encoded by: hsa:29929
name: ALG6
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM sbcoa c
boundary condition: false
is: SBO:0000247
is: C02838
constant: false
type: Species
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
has only substance units: false
initial concentration: 1.0
name: suberylcoa
is: HMDB00791
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_6af289d1_80c4_46c8_889e_07b7bd66bd81
constant: false
initial concentration: NaN
has only substance units: false
is: A8K3J4
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CA14
is encoded by: hsa:23632
type: Species

metaM cs e deg4 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C31H46NO38S4 CHARGE: -5
constant: false
initial concentration: 1.0
is: HMDB00127
boundary condition: false
is: SBO:0000247
is: CHEBI:15748

metaM ttdca e
name: tetradecanoate (n-C14:0)
constant: false
is: C06424
type: Species
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
initial concentration: 1.0
is: CHEBI:30807
boundary condition: false
initial amount: NaN
is: HMDB00806
has only substance units: false
is: SBO:0000247

metaR AMETtd
name: diffusion of S-Adenosyl-L-methionine
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110050#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
type: Reaction

metaM prostgh2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: HMDB01381
is: CHEBI:57405
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: prostaglandin H2(1-)
constant: false
initial amount: NaN
type: Species
boundary condition: false

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_798d7b04_e995_4388_9689_fb6f913dfa99
is: A8K5Z0
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8703
initial amount: NaN
boundary condition: true
name: B4GALT3

metaM 4abut m
initial amount: NaN
is: C00334
is: SBO:0000247
boundary condition: false
name: 4-Aminobutanoate
type: Species
initial concentration: 1.0
is: HMDB00112
has only substance units: false
is: CHEBI:16865
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334

http://identifiers.org/biomodels.db/MODEL1310110050#_f8d56b77_d29c_47aa_875c_22b4ec8f4313
boundary condition: true
initial amount: NaN
is: Q99707
name: MTR
has only substance units: false
is encoded by: hsa:4548
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM c3dc e
is: HMDB02095
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C10H16NO6 CHARGE: -1
name: malonyl carnitine
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_810f91ee_c9f0_49ff_a571_baede808d1d9
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2592
type: Species
initial amount: NaN
name: GALT
initial concentration: NaN
is: B2RAT6

metaM hs l
initial amount: NaN
has only substance units: false
is: CHEBI:28815
is: SBO:0000247
boundary condition: false
type: Species
name: heparan sulfate, free chain
constant: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_2a41fec9_406e_4c3c_aebf_54ddbd5cba98
name: SDHA
is encoded by: hsa:6389
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: P31040

metaM hco3 m
has only substance units: false
name: Bicarbonate
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
type: Species
is: CHEBI:17544
is: C00288
initial concentration: 1.0
is: HMDB00595
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_2aa56452_24c1_433a_a432_4b76eb518be8
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3157
name: HMGCS1
is: SBO:0000252
constant: false
type: Species
is: Q01581

metaM 4abut n
initial amount: NaN
is: HMDB00112
boundary condition: false
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00334
has only substance units: false
constant: false

metaR PDX5PO
product: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
reversible: true
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000269
name: pyridoxine 5'-phosphate oxidase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5

metaM g1m8mpdol L r
is: C05870
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_ca635dff_3f38_445f_acec_177b53af64cd
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: _AA532636_1_m
constant: false
is encoded by: hsa:AA532636
boundary condition: true

metaR P5CDm
product: MODEL1310110050#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
type: Reaction
reversible: false
reactant: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD

metaR SEBCOACROT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR AMPtp
name: AMP transporter, peroxisome
fast: false
type: Reaction
reactant: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is: SBO:0000185
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#

metaR LFORKYNHYD
reversible: false
modifier: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (8942.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 1 AUTHORS: NOTES:SAB changed to L form
name: L-Formylkynurenine hydrolase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.7.1.3
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000212
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_96909e1e_8370_49d4_86d2_110e49f5d517
constant: false
has only substance units: false
name: ALAS1
initial amount: NaN
boundary condition: true
type: Species
is: P13196
is encoded by: hsa:211
initial concentration: NaN
is: SBO:0000252

metaM prostge2 c
has only substance units: false
constant: false
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
is: SBO:0000247
is: CHEBI:606564
boundary condition: false
initial concentration: 1.0
is: HMDB01220
type: Species

metaR r1634
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#

metaM glcur r
has only substance units: false
is: CHEBI:15748
initial amount: NaN
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
name: D-glucuronate
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

metaM dgmp c
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP
type: Species
is: SBO:0000247
is: CHEBI:57673
has only substance units: false
initial amount: NaN
is: HMDB01044
is: C00362

metaR EX thmtp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiamin triphosphate exchange
type: Reaction

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaR ECOAH12m
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR DOLPMT2 Ler
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_b39a4aa4_3590_4137_9fcf_920a900ca3db
initial concentration: NaN
has only substance units: false
name: BAAT
is encoded by: hsa:570
is: Q14032
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaR NH4tp
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110050#
fast: false
name: ammonia peroxisomal transport

metaR r1635
is: SBO:0000185
reactant: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_eb2fc1c8_a56f_4a1d_822f_cfd9fce82684
is: SBO:0000252
is encoded by: hsa:158
name: ADSL
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_21d27a67_bb13_4b74_8b50_a176d4c67aff
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: _AI769281_1_e
has only substance units: false
is encoded by: hsa:AI769281
initial amount: NaN

metaM na1 r
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
name: sodium(1+)
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00588
is: CHEBI:29101

metaM thymd e
initial amount: NaN
name: Thymidine
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00273
is: C00214
is: CHEBI:17748
boundary condition: false
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

http://identifiers.org/biomodels.db/MODEL1310110050#_5042ab2f_30ce_4cca_a82e_f50352536f19
has only substance units: false
is: SBO:0000252
type: Species
name: PDE3B
boundary condition: true
is encoded by: hsa:5140
initial concentration: NaN
is: A7E2E5
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_7917c74b_b9b2_4bb4_b3f0_bf47f2f9b503
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA526438
name: _AA526438_1_m
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_e67db07b_e678_4340_8100_d40982eaa9cb
name: PDE1C
is encoded by: hsa:5137
boundary condition: true
initial amount: NaN
is: Q8NB10
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR RDH3a
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
reactant: MODEL1310110050#
name: retinol dehydrogenase (11-cis,NADPH)
type: Reaction
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reversible: true
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.105

http://identifiers.org/biomodels.db/MODEL1310110050#_c25bba57_4b08_4e42_a55c_253ba28dd9b6
type: Species
boundary condition: true
is encoded by: hsa:84693
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: MCEE
is: Q96PE7
is: SBO:0000252
constant: false

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110050#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110050#
reversible: true
name: RE3524

metaR r1636
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#

metaM m4mpdol L r
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37633
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaM mlthf c
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01533
initial amount: NaN
is: C00143
type: Species
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
has only substance units: false

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR PYDAMK
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: pyridoxamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.35
product: MODEL1310110050#
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_9b2b57eb_4fd0_44d8_b1bc_91cb391d84b6
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _T83654_1_c
is: SBO:0000252
is encoded by: hsa:T83654
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_3d283b2f_39f6_4aaa_ae1c_a2ebee3641c9
is: P04746
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: AMY2A
is encoded by: hsa:279
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_752fe4b6_b3b2_46ae_8d13_8ed4168599a9
initial amount: NaN
initial concentration: NaN
name: B4GALNT1
constant: false
boundary condition: true
is: Q59FK0
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2583
type: Species

metaM dgmp e
boundary condition: false
initial concentration: 1.0
name: dGMP(2-)
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57673
is: HMDB01044
has only substance units: false
constant: false

metaM crn r
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
name: (R)-carnitine
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
is: HMDB00062
constant: false

metaR NH4tn
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
name: ammonia nuclear transport
is described by: ECO:0000000
reversible: true
product: MODEL1310110050#
is: SBO:0000185
fast: false

metaM ksi pre32 g
initial concentration: 1.0
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 32

metaR r1637
is described by: ECO:0000000
reactant: MODEL1310110050#
modifier: MODEL1310110050#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM thymd c
name: Thymidine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:17748
is: C00214
has only substance units: false
type: Species
is: HMDB00273
constant: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

metaM m3mpdol L c
constant: false
has only substance units: false
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
initial amount: NaN
is: CHEBI:37632
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR NH4t3r
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
name: ammonia transport via proton antiport
is: SBO:0000185
modifier: MODEL1310110050#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110050#_77081abe_3ba7_47e5_a2f0_09362b883b63
is: SBO:0000252
has only substance units: false
constant: false
name: CYP7A1
initial amount: NaN
type: Species
is encoded by: hsa:1581
boundary condition: true
initial concentration: NaN
is: P22680

metaR 34DHPLACOX
modifier: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_47755584_9f70_4ef1_8981_275a2d62429d
initial concentration: NaN
is encoded by: hsa:2348
name: FOLR1
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR CMPACNAtn
product: MODEL1310110050#
is: SBO:0000185
name: CMP-Sia nuclear export
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#

metaR FUMSO4tm
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000269
name: Fumarate:sulfate antiport, mitochondrial
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000185
kinetic law: MODEL1310110050#
type: Reaction

metaM C05280 m
is: HMDB03952
is: CHEBI:28002
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0
is: SBO:0000247
name: cis,cis-3,6-Dodecadienoyl-CoA

metaM asp L c
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:29991
boundary condition: false
is: HMDB00191
initial concentration: 1.0
name: L-aspartate(1-)

http://identifiers.org/biomodels.db/MODEL1310110050#_c1d642ad_5349_48fa_b009_9284bb4ab79f
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P39656
is: SBO:0000252
constant: false
name: DDOST
is encoded by: hsa:1650
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_13d81aaa_8f03_40c7_85bb_1a0d10c72c4a
is encoded by: hsa:81539
type: Species
is: Q9H2H9
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC38A1

metaR r1630
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#

metaM leu L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00687
name: L-leucine
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:15603
initial amount: NaN

metaM crn x
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: HMDB00062
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00318
type: Species
is: CHEBI:16347
constant: false
boundary condition: false
name: L-Carnitine

metaR UAGDP
name: UDP-N-acetylglucosamine diphosphorylase
is described by: ECO:0000269
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
reversible: false
modifier: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.23

metaR G14T12g
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110050#
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM 4ppcys c
is: SBO:0000247
is: CHEBI:59458
is: HMDB01117
has only substance units: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: C04352
constant: false
boundary condition: false
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_42a8899d_ba62_4cf4_84e4_5d5a9239ab9f
type: Species
is: Q9Y2A9
constant: false
has only substance units: false
is encoded by: hsa:10331
boundary condition: true
name: B3GNT3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM urea c
constant: false
is: HMDB00294
name: Urea
is: CHEBI:16199
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: C00086
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_b48980fd_dba0_4fb8_ae9c_a0fcaa972e09
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ADCY10
constant: false
is: F5GWS5
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:55811

metaR r1381
is described by: ECO:0000000
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
fast: false

metaR SIAT9g
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
reversible: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
type: Reaction
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.9
reactant: MODEL1310110050#

metaR r1631
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_7b537b22_e5b7_4fc9_a7d8_dd1b24fbd2df
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: BCKDHB
boundary condition: true
is encoded by: hsa:594
is: P21953
type: Species
has only substance units: false

metaR LYStip
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
reactant: MODEL1310110050#
name: L-lysine transport, peroxisomal (irreversible)
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#

metaR S6T13g
type: Reaction
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_3fa6be0b_55cd_488a_b3a0_31f4f416e848
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51079
is: SBO:0000252
is: Q9P0J0
initial amount: NaN
constant: false
name: NDUFA13

metaR RE3556C
reactant: MODEL1310110050#
fast: false
name: RE3556
type: Reaction
product: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaR ATP1ter
product: MODEL1310110050#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: ADP/ATP transporter, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110050#
type: Reaction

metaM hs deg5 l
name: heparan sulfate, degradation product 5
is: HMDB00158
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
type: Species
initial concentration: 1.0
is: CHEBI:17895
constant: false

metaR r1632
fast: false
is: SBO:0000185
modifier: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110050#

metaM HC01407 m
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
is: CHEBI:28276
boundary condition: false
initial amount: NaN
name: (S)-Hydroxyhexanoyl-CoA

metaR C5DCe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM 3hmp m
type: Species
is: SBO:0000247
is: CHEBI:11805
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 3-hydroxy-2-methylpropanoate
is: HMDB00023
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f56915a5_e88c_4ac5_a130_cbe5c2910f3e
is encoded by: hsa:23305
is: B2RB13
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ACSL6
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

metaM urea e
is: HMDB00294
is: CHEBI:16199
name: Urea
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00086
constant: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086

metaM arachcrn m
boundary condition: false
initial concentration: 1.0
name: arachidyl carnitine
is: HMDB06460
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_122d51f8_4a74_48ed_9685_f23fe94ed00b
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ACADL
is: P28330
is encoded by: hsa:33
has only substance units: false

metaR ADEt
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
name: adenine reversible transport, cytosol
is: SBO:0000185
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
product: MODEL1310110050#
is described by: ECO:0000269
type: Reaction

metaM dtdp m
type: Species
is: HMDB01274
constant: false
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: dTDP
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:58369

metaR r1786
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
reversible: false
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_d8d601e4_3b15_45a4_86fc_6858b2f73677
initial amount: NaN
is encoded by: hsa:1892
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: ECHS1
constant: false
is: P30084

metaR r1633
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM fprica c
initial amount: NaN
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: C04734
constant: false
initial concentration: 1.0
is: CHEBI:58467
is: SBO:0000247
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
type: Species
has only substance units: false
is: HMDB01439

http://identifiers.org/biomodels.db/MODEL1310110050#_f1d9c4a2_4b34_43a6_b6de_6f1ca1526485
name: DLAT
is: Q86YI5
is encoded by: hsa:1737
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_4cae3227_3d19_4c52_ac77_3b904b2e7b7b
has only substance units: false
is encoded by: hsa:126129
is: Q8TCG5
initial amount: NaN
constant: false
name: CPT1C
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM hco3 e
initial amount: NaN
is: CHEBI:17544
name: Bicarbonate
is: C00288
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00595

http://identifiers.org/biomodels.db/MODEL1310110050#_f0a2adf1_151a_49a3_b0d6_29b2dc71db0f
is encoded by: hsa:AV717590
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: _AV717590_1_c

metaR HSPASEly
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
reactant: MODEL1310110050#
name: heparan sulfate proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false

metaM dtdp n
type: Species
is: HMDB01274
constant: false
initial concentration: 1.0
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR r1380
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
type: Reaction
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_83b12978_68bd_4470_b55d_6426c2829982
name: PIK3CD:PIK3R1
initial amount: NaN
is: SBO:0000297
boundary condition: true
has part: E7EX19
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5295

http://identifiers.org/biomodels.db/MODEL1310110050#_2540ddd7_b285_489e_bd73_0c76656e21ff
is: SBO:0000252
is encoded by: hsa:130
constant: false
initial amount: NaN
name: ADH6
is: P28332
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaM tetdec2crn c
constant: false
is: HMDB02014
initial amount: NaN
type: Species
notes: FORMULA: C21H37NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: tetradecadienoyl carnitine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_edb0188b_6f80_4c51_a0f1_567a65fffb30
is: O00767
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:6319
name: SCD
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM 6dhf e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
initial amount: NaN
boundary condition: false
is: HMDB06563
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_79c4534c_7b28_4cf2_b67a_31385d1bf77a
initial amount: NaN
is: Q9BRC7
is: SBO:0000252
has only substance units: false
name: PLCD4
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:84812

metaR FACOAL150
product: MODEL1310110050#
reactant: MODEL1310110050#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is described by: ECO:0000000
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
name: fatty-acid--CoA ligase

metaM HC02180 e
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
is: SBO:0000247
is: CHEBI:28728
initial amount: NaN
has only substance units: false
constant: false

metaR r0541
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000176
reversible: true
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#

metaM utp c
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
name: UTP
is: C00075
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:46398

metaM 5adtststerone c
is: SBO:0000247
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
is: HMDB02961
initial concentration: 1.0
constant: false
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
boundary condition: false

metaR UDPGLCter
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
product: MODEL1310110050#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaM pe hs e
name: phosphatidylethanolamine
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
is: CHEBI:16038
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_6ac8e861_0e74_41b8_b8ce_80de74796eac
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: GBA
is: B7Z5G2
initial concentration: NaN
is encoded by: hsa:2629
type: Species

metaM atp e
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00538
type: Species
name: ATP(4-)
boundary condition: false
is: C00002
initial amount: NaN
is: SBO:0000247
is: CHEBI:57299

metaM Nacasp m
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
initial concentration: 1.0
name: N-acetyl-L-aspartate(2-)
constant: false
type: Species
has only substance units: false
is: HMDB00812

metaR 5ADTSTSTERONEte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
name: 5 alpha dihydrotesterone transport

metaR PE HStm
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
name: phosphatidylethanolamine scramblase
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_fa7ab361_7d00_4ef0_99ab_4ba10b41bb45
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: OCRL
boundary condition: true
is encoded by: hsa:4952
type: Species

metaM odecoa c
boundary condition: false
is: CHEBI:3793
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
has only substance units: false

metaM gncore2 g
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:15876
name: GlcNAc-alpha-1,4-Core 2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_81f7ef56_6477_433b_b02d_6792e22b49f7
boundary condition: true
is encoded by: hsa:5279
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: PIGC

metaR EX c5dc
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR GLCNACASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5c79234e_783f_450a_8e79_fb8b741c25a3
initial amount: NaN
is: Q9UBK5
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: HCST
boundary condition: true
has only substance units: false
is encoded by: hsa:10870

http://identifiers.org/biomodels.db/MODEL1310110050#_252a4a79_46ca_4272_a49d_3ab70be86524
initial amount: NaN
is encoded by: hsa:10965
is: P49753
name: ACOT2
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR BDMT L
reversible: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.142
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110050#

metaM hco3 c
is: CHEBI:17544
name: Bicarbonate
type: Species
is: HMDB00595
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false
is: C00288
initial amount: NaN
is: SBO:0000247
constant: false

metaM utp e
name: UTP(4-)
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00285
is: CHEBI:46398

metaR r0129
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110050#
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110050#
reactant: MODEL1310110050#

metaM Lpipecol x
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:30913
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: L-pipecolic acid
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: HMDB00716

metaR SUCCOAPET
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM 5adtststerone e
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:16330

http://identifiers.org/biomodels.db/MODEL1310110050#_913ba74d_a229_4189_bb8f_794cb91c547d
name: EHHADH:ACAA1:HSD17B4:ACOX3
is encoded by: hsa:8310
initial amount: NaN
boundary condition: true
has part: O15254
is encoded by: hsa:1962
has only substance units: false
constant: false
is: SBO:0000297
initial concentration: NaN
type: Species
has part: Q9NY65

metaM i c
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
boundary condition: false
has only substance units: false
is: HMDB12238
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
name: iodide
is: CHEBI:16382

http://identifiers.org/biomodels.db/MODEL1310110050#_45f8c3fe_fe04_439f_8f4b_850cc54acdf9
has only substance units: false
initial amount: NaN
name: ABAT
boundary condition: true
is: SBO:0000252
is encoded by: hsa:18
constant: false
initial concentration: NaN
type: Species

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_5611699e_e1e4_408e_917e_8eca98a32e21
name: NT5M
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q9NPB1
is encoded by: hsa:56953
type: Species
initial concentration: NaN

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaR C4CRNe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_0ac99276_1ccd_4dcd_9032_279840515c27
initial amount: NaN
name: SLC5A5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6528
is: Q92911
type: Species
boundary condition: true

metaR SERGLYexR
reactant: MODEL1310110050#
modifier: MODEL1310110050#
product: MODEL1310110050#
fast: false
reversible: true
name: L-Serine/Glycine reversible exchange
kinetic law: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185

metaR PALFATPtc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaM pmtcoa m
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: HMDB01338
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: C00154
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
type: Species

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_e4bcdd4b_f0bd_4763_8f5e_3276fd6e2fad
initial concentration: NaN
boundary condition: true
is: P34949
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4351
type: Species
initial amount: NaN
name: MPI

metaM ser D e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:16523
constant: false
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
boundary condition: false
type: Species
is: HMDB03406
name: D-serine

metaM 34hpp c
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:36242
has only substance units: false
name: 3-(4-hydroxyphenyl)pyruvate
initial amount: NaN
is: SBO:0000247
is: HMDB00707
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

http://identifiers.org/biomodels.db/MODEL1310110050#_8bb5411f_4965_4c9f_ba96_113cd1f46672
is: Q5MY95
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ENTPD8
is encoded by: hsa:377841
type: Species
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_7a8b3832_4dab_4dfc_8ae9_315b43998d8a
type: Species
boundary condition: true
name: _NOS2A_1_c
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:NOS2A

metaR r0545
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is: SBO:0000176
reactant: MODEL1310110050#
product: MODEL1310110050#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_dc81b7d5_c36b_4bb7_8889_48f246b9dfd5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:27306
name: HPGDS
constant: false
is: O60760
initial amount: NaN
type: Species
boundary condition: true

metaM i e
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16382
is: SBO:0000247
name: iodide
initial concentration: 1.0

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaM etfox m
name: Electron transfer flavoprotein oxidized
constant: false
initial amount: NaN
is: CHEBI:16469
type: Species
boundary condition: false
notes: FORMULA: R CHARGE: 0
is: SBO:0000247
has only substance units: false
is: HMDB00151
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_4e9ffa97_a366_47a8_9c06_5722e9a30859
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: IVD
has only substance units: false
is: B3KVI7
boundary condition: true
is encoded by: hsa:3712
initial concentration: NaN

metaR r1923
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110050#
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_eaae86f0_0c97_49be_ade6_63970c4385d5
has only substance units: false
name: ATP5D
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:513

metaR FAS180COA
name: fatty-acyl-CoA synthase (n-C18:0CoA)
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5e11fcee_594e_44d2_bdfe_6cace3f2fd27
is encoded by: hsa:5332
type: Species
is: Q15147
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: PLCB4

metaR SO4tl
is described by: ECO:0000269
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110050#
reversible: true
reactant: MODEL1310110050#
name: Sulfate transport (lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:

metaR C12OHc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_a7b373b7_b36b_43e9_9545_94ca476b792d
boundary condition: true
has only substance units: false
is encoded by: hsa:8526
is: A1L4Q0
constant: false
initial amount: NaN
name: DGKE
is: SBO:0000252
type: Species
initial concentration: NaN

metaM HC02180 c
is: SBO:0000247
has only substance units: false
is: CHEBI:28728
boundary condition: false
name: thromboxane-b2
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial concentration: 1.0
type: Species
initial amount: NaN

metaR AG13T15g
modifier: MODEL1310110050#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110050#
reactant: MODEL1310110050#

metaR LNLNCGt
product: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
reactant: MODEL1310110050#
name: fatty acid transport via diffusion
is described by: ECO:0000000

metaR O2t
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
type: Reaction
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
name: o2 transport (diffusion)

metaM ser D c
is: CHEBI:16523
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
boundary condition: false
name: D-serine
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB03406
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_751cbeff_1d58_47a6_9801_0eb50dbe6175
type: Species
initial concentration: NaN
is: O43570
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:771
has only substance units: false
constant: false
name: CA12

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR B MANNASEly
is: SBO:0000176
is described by: ECO:0000000
name: beta-mannosidase, lysosomal
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction
modifier: MODEL1310110050#
reversible: false

metaM atp m
boundary condition: false
is: CHEBI:57299
has only substance units: false
name: ATP(4-)
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00002
is: HMDB00538
is: SBO:0000247
constant: false

metaM 34hpp e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
constant: false
boundary condition: false
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
type: Species
is: CHEBI:36242

metaR r0547
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR RE1523M
type: Reaction
reactant: MODEL1310110050#
name: RE1523
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#

metaM xolest2 hs e
is: CHEBI:17002
constant: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: cholesterol ester
boundary condition: false
type: Species
is: SBO:0000247

metaR CITt4 2
fast: false
name: citrate transport via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR ELAIDCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110050#
type: Reaction
fast: false
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_134061b6_1396_4172_958b_22f7c998621f
is: P52789
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:3099
name: HK2
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_6c5c0eb1_0855_4853_9307_7b876479fe2c
constant: false
name: PPT2
initial concentration: NaN
is: Q9UMR5
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:9374

metaR ILEt5m
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
reversible: true
kinetic law: MODEL1310110050#

metaR ARGt4
fast: false
modifier: MODEL1310110050#
is described by: ECO:0000304
product: MODEL1310110050#
reversible: false
name: L-arginine transport in via sodium symport
is: SBO:0000185
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110050#

metaR ELAIDCPT2
product: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
name: carnitine transferase
kinetic law: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110050#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM ksi pre11 g
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
name: keratan sulfate I biosynthesis, precursor 11
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:28067
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_15e1c03a_cafc_4e56_a309_4403552b099e
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110050#_fa863d51_fa1b_4a11_a24b_911060c688df
name: _BF195998_1_x
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:BF195998
has only substance units: false
initial amount: NaN

metaM o2 x
boundary condition: false
is: HMDB01377
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
type: Species
constant: false
is: C00007
has only substance units: false
is: SBO:0000247
is: CHEBI:15379
initial amount: NaN

metaM dcmp n
is: SBO:0000247
name: dCMP(2-)
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01202
constant: false
initial amount: NaN
is: CHEBI:57566

metaM 4mop c
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: 4-methyl-2-oxopentanoate
type: Species
is: HMDB00695
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865

metaM HC01444 e
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: Galactosylglycerol
is: CHEBI:15754
boundary condition: false
has only substance units: false

metaR r2514
name: Utilized transport
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
reversible: true

metaM paps c
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
type: Species
initial concentration: 1.0
is: CHEBI:58339

metaM na1 c
initial concentration: 1.0
name: Sodium
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C01330
is: HMDB00588
initial amount: NaN
type: Species
notes: FORMULA: Na CHARGE: 1
constant: false
is: CHEBI:4541

http://identifiers.org/biomodels.db/MODEL1310110050#_085a4f9d_06f3_4a9c_8061_645acc94aaa2
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:R51273
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: _R51273_1_c

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR G14Tg
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is: SBO:0000176
product: MODEL1310110050#
is described by: ECO:0000269
modifier: MODEL1310110050#
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

metaM m4mpdol L c
constant: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
is: CHEBI:37633
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
has only substance units: false
boundary condition: false
initial amount: NaN

metaM mi34p c
is: SBO:0000247
boundary condition: false
name: 1D-myo-Inositol 3,4-bisphosphate
constant: false
is: HMDB06235
has only substance units: false
is: CHEBI:28858
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
type: Species
initial concentration: 1.0
initial amount: NaN

metaR RE2079R
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110050#
type: Reaction
is: SBO:0000176
product: MODEL1310110050#
name: RE2079
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_db5080bb_8b29_4454_995c_6ba12a760a7f
type: Species
is: SBO:0000252
boundary condition: true
name: _AA854479_1_m
constant: false
is encoded by: hsa:AA854479
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR Rtotaltl
reversible: true
is: SBO:0000185
name: fatty acid intracellular transport
type: Reaction
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000000

metaM o2 r
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
boundary condition: false
is: CHEBI:15379
is: C00007
has only substance units: false
type: Species
name: O2
initial amount: NaN

metaM atp n
boundary condition: false
name: ATP(3-)
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00538
is: CHEBI:57299
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR OLEICFATPtc
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR SUBERCACT
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaM glcur c
constant: false
boundary condition: false
type: Species
is: HMDB00127
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:15748
name: D-glucuronate

metaR RE1521M
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reversible: true
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1521
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110050#
type: Reaction

metaR HGNTOR
reactant: MODEL1310110050#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110050#
fast: false
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.13.11.5
product: MODEL1310110050#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110050#_2125be26_12da_43f5_b762_6a0ee29332ac
is: O00142
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7084
constant: false
name: TK2

http://identifiers.org/biomodels.db/MODEL1310110050#_6e20ef35_3a4c_44f6_a2c0_ef1724b64de2
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: DGUOK
constant: false
is encoded by: hsa:1716
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_c5c10508_fa6a_4ba5_b700_35689bc9d19f
boundary condition: true
is: E9PCX6
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:440
initial amount: NaN
name: ASNS
initial concentration: NaN
type: Species

metaM 4mop e
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial amount: NaN
is: HMDB00695
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: 4-methyl-2-oxopentanoate
constant: false
is: CHEBI:17865

http://identifiers.org/biomodels.db/MODEL1310110050#_e1814b31_1dfa_48a1_9c31_cd2012cc2a04
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: F8W7V3
initial concentration: NaN
name: ATP5J2
is: SBO:0000252
type: Species
is encoded by: hsa:9551

metaR FATP1t
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110050#
name: fatty acid electroneutral transport
type: Reaction
reactant: MODEL1310110050#
reversible: true
modifier: MODEL1310110050#
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ

metaM cs a deg3 l
notes: FORMULA: C31H48NO32S2 CHARGE: -3
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:15748
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
is: HMDB00127
boundary condition: false
initial concentration: 1.0
type: Species

metaR r2516
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
type: Reaction
reversible: true
is: SBO:0000185

metaR DUDPtn
type: Reaction
reversible: true
product: MODEL1310110050#
is described by: ECO:0000000
name: dUDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_e17cc474_d81e_4603_9ae7_7d9b16975a41
constant: false
is encoded by: hsa:57835
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC4A5
initial concentration: NaN
has only substance units: false

metaM pmtcoa c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00154
type: Species
boundary condition: false
is: CHEBI:3454
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)

metaM CE2416 x
constant: false
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
boundary condition: false
is: CHEBI:57923
name: (2R,6S,10S)-pristanate
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_613993e2_c1ed_4539_b7e1_e413833b929a
has only substance units: false
is: SBO:0000252
constant: false
name: PPOX
initial concentration: NaN
type: Species
is encoded by: hsa:5498
is: P50336
initial amount: NaN
boundary condition: true

metaR ASPGLUm
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
name: aspartate-glutamate mitochondrial shuttle
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
is described by: ECO:0000269
is: SBO:0000185

metaM dolp L c
name: dolichyl phosphate(2-)
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_b24c7112_961a_4dfc_9ec1_fd8af9aac7b6
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _H53099_1_m
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:H53099

http://identifiers.org/biomodels.db/MODEL1310110050#_07082504_85cb_456e_a414_2b9402efa4ed
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ELOVL4
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6785
is: Q9GZR5
type: Species

metaR S4TASE1ly
type: Reaction
product: MODEL1310110050#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12

http://identifiers.org/biomodels.db/MODEL1310110050#_ffd0f71b_7faf_40c4_8820_e7b6b5fd7b6c
has only substance units: false
initial amount: NaN
is: Q8WUM9
name: SLC20A1
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6574
boundary condition: true

metaR HS3ly
is described by: ECO:0000000
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.10.1.1
reversible: false
is: SBO:0000176
fast: false
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#

metaM arachcrn c
is: HMDB06460
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: arachidyl carnitine
type: Species
constant: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5643d8c0_9074_4933_90dc_cb72c5023f7d
boundary condition: true
name: _X63359_1_c
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:X63359

metaR DM gpi sig er
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR UAG4E
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.2
product: MODEL1310110050#
modifier: MODEL1310110050#
name: UDP-N-acetylglucosamine 4-epimerase
reversible: true
kinetic law: MODEL1310110050#

metaR SMPD3g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.12
is described by: ECO:0000304
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
modifier: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
product: MODEL1310110050#
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
fast: false
reversible: false

metaM dcmp c
type: Species
is: CHEBI:57566
has only substance units: false
is: SBO:0000247
is: HMDB01202
initial concentration: 1.0
boundary condition: false
constant: false
is: C00239
initial amount: NaN
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP

http://identifiers.org/biomodels.db/MODEL1310110050#_6101c973_a94b_4c8c_9635_530687ce7854
constant: false
initial concentration: NaN
name: PLCXD2
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:257068
has only substance units: false
boundary condition: true
is: Q0VAA5

metaM ptrc e
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
boundary condition: false
has only substance units: false
name: Putrescine
is: HMDB01414
is: C00134
is: CHEBI:326268
is: SBO:0000247

metaM paps g
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
constant: false
is: SBO:0000247
is: HMDB01134
type: Species
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

http://identifiers.org/biomodels.db/MODEL1310110050#_d4044079_31f2_4b22_b844_87b2c54fc948
is: Q9NQR4
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:56954
boundary condition: true
name: NIT2
initial concentration: NaN
is: SBO:0000252
type: Species

metaM atp r
initial concentration: 1.0
initial amount: NaN
is: HMDB00538
is: CHEBI:57299
constant: false
type: Species
name: ATP(4-)
is: C00002
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR IDOAASE3ly
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
name: alpha-L-iduronidase, lysosomal
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_50852dd3_5441_4ca8_ae03_cfea12be0993
initial amount: NaN
is: Q9P1E4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4122
name: MAN2A2
constant: false
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_00c55143_e175_4fdb_87d2_8ee201ddea5f
has only substance units: false
type: Species
is encoded by: hsa:427
initial amount: NaN
is: Q13510
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: ASAH1

metaM utp n
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial amount: NaN
name: UTP(4-)
is: CHEBI:46398
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00285

metaR PI45P5P
reactant: MODEL1310110050#
is: SBO:0000176
fast: false
product: MODEL1310110050#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR FAOXC183806m
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
name: Beta oxidation of fatty acid
reactant: MODEL1310110050#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110050#
is: SBO:0000176
type: Reaction

metaR EX glypro LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Glycylproline exchange
type: Reaction

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_ce16c2ab_6415_49e0_a3ae_f0d507b7afe8
initial amount: NaN
type: Species
is: Q9HAS3
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:64078
name: SLC28A3
is: SBO:0000252

metaM fmn c
is: CHEBI:58210
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: C00061
has only substance units: false
name: FMN
type: Species
is: HMDB01520
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_a317c15e_754f_4d26_b441_0a88f5240f68
is: P04062
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:2629
initial amount: NaN
name: GBA
has only substance units: false

metaR NDPK6n
reactant: MODEL1310110050#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000304
is: SBO:0000176
kinetic law: MODEL1310110050#

metaM prist c
is: CHEBI:51340
initial concentration: 1.0
boundary condition: false
is: HMDB00795
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: SBO:0000247
name: pristanic acid
constant: false

metaR CSAPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
fast: false
reactant: MODEL1310110050#
is: SBO:0000176
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reversible: false
product: MODEL1310110050#
type: Reaction

metaM HC01410 m
constant: false
name: (2E)-Hexenoyl-CoA
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28706

metaR BUTt2r
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
kinetic law: MODEL1310110050#
name: Butyrate transport via proton symport, reversible

metaM fe2 m
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692
constant: false
is: C00023
initial amount: NaN
has only substance units: false
name: Fe2+
is: SBO:0000247
is: CHEBI:29033
type: Species
boundary condition: false
initial concentration: 1.0

metaR MMEm
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/5.1.99.1
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: methylmalonyl-CoA epimerase/racemase
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
name: inositol-1,4,5-trisphosphate 5-phosphatase
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
product: MODEL1310110050#
is: SBO:0000176
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110050#_c6142c77_d71b_4a54_ace9_7417a9d22fa7
type: Species
initial amount: NaN
is encoded by: hsa:5322
is: P39877
has only substance units: false
initial concentration: NaN
name: PLA2G5
is: SBO:0000252
boundary condition: true
constant: false

metaR FAOXC5C5OHm
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR r2519
is described by: ECO:0000000
kinetic law: MODEL1310110050#
fast: false
reversible: true
name: Utilized transport
product: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_09d61467_45bf_4c94_bde4_3c5886f12012
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8883
has only substance units: false
is: A8MU28
constant: false
initial concentration: NaN
name: NAE1
type: Species

metaM octd11ecoa c
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: 11-octadecenoylcoa
is: C08277
constant: false
is: HMDB00792
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_5a8d4bf6_17e3_402c_bdc6_0e19c7dcc9d4
initial amount: NaN
has only substance units: false
name: ACOT2
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10965
initial concentration: NaN
is: P49753
type: Species

metaM pe hs c
name: phosphatidylethanolamine
is: CHEBI:16038
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaM pcrn x
constant: false
is: HMDB00824
is: http://identifiers.org/pubchem.compound/107738
boundary condition: false
has only substance units: false
initial amount: NaN
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM glcur e
has only substance units: false
type: Species
constant: false
is: HMDB00127
initial amount: NaN
name: D-glucuronate
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_0d1a2c84_0990_463b_93e0_f56e2480914c
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: P36269
is: SBO:0000252
name: GGT5
is encoded by: hsa:2687

http://identifiers.org/biomodels.db/MODEL1310110050#_83ffbb38_c7fd_4d0d_8433_292fa404f115
has only substance units: false
initial concentration: NaN
is: F6SH78
constant: false
is encoded by: hsa:60481
boundary condition: true
name: ELOVL5
initial amount: NaN
type: Species
is: SBO:0000252

metaR GLYOp
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
kinetic law: MODEL1310110050#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110050#
name: glycine oxidase, perixosomal
fast: false
reversible: false
reactant: MODEL1310110050#
type: Reaction

metaR r0281
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
fast: false
modifier: MODEL1310110050#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#

metaR RE3241R
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000000
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: RE3241
reversible: false
fast: false
is: SBO:0000176

metaM HC00822 e
boundary condition: false
has only substance units: false
name: Chitobiose
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28681
is: SBO:0000247
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674

metaM ksi pre17 g
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 17
is: SBO:0000247
is: CHEBI:28067
notes: FORMULA: C157H252N11O127S5X CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110050#_93ae09a0_1bd3_4217_8d03_4ffb499ada42
is: SBO:0000252
name: AADAT
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q8N5Z0
is encoded by: hsa:51166
constant: false
initial concentration: NaN

metaR r1640
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#
reversible: true
is: SBO:0000185
type: Reaction

metaM spmd c
boundary condition: false
is: CHEBI:57834
initial concentration: 1.0
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: C00315
has only substance units: false
is: SBO:0000247
name: Spermidine
initial amount: NaN
is: HMDB01257
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_27903ac2_3790_4c9e_a8a0_41134e275976
boundary condition: true
is encoded by: hsa:10841
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: FTCD

http://identifiers.org/biomodels.db/MODEL1310110050#_0ec197ab_34c9_4a66_b5ee_b0ced44046b8
is: SBO:0000252
initial concentration: NaN
constant: false
name: ATP5J
boundary condition: true
is encoded by: hsa:522
type: Species
initial amount: NaN
has only substance units: false

metaM pmtcoa x
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
is: HMDB01338
boundary condition: false
type: Species
is: C00154
is: CHEBI:57379
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM 1p3h5c m
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:6151
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: HMDB01369
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
boundary condition: false
type: Species
constant: false

metaR ADRNCRNt
kinetic law: MODEL1310110050#
reversible: false
fast: false
product: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110050#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110050#_4b817506_2ddc_4ced_98a3_56b66527845a
type: Species
has only substance units: false
is: B7Z6M3
is encoded by: hsa:8525
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: DGKZ
constant: false

metaR GLYPROPRO1c
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Prolylglycine in the small intestine for cellular uptake
type: Reaction

metaR SPMTDe
reactant: MODEL1310110050#
product: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
name: SPMTDe
is: SBO:0000185

metaM HC02216 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false
name: prostaglandin-f2beta
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28922
initial amount: NaN
type: Species

metaM fe2 c
is: SBO:0000247
has only substance units: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
is: C00023
name: Fe2+
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:29033
initial amount: NaN
is: HMDB00692

metaM octd11ecoa m
name: 11-octadecenoylcoa
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB06294
initial amount: NaN

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_5fddda47_9234_4377_85e2_b4c49b4ec600
boundary condition: true
constant: false
name: _R33828_1_c
is encoded by: hsa:R33828
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

metaR r1641
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
fast: false
reversible: true
modifier: MODEL1310110050#
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110050#_6bf75652_a15f_4fd8_ace3_1a51b120664c
is: P15531
type: Species
constant: false
is encoded by: hsa:4830
has only substance units: false
boundary condition: true
name: NME1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR C160CPT1
fast: false
product: MODEL1310110050#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
modifier: MODEL1310110050#
name: production of Palmitoylcarnitine

metaR GLCSGLT1le
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaM thr L e
is: CHEBI:16857
name: L-threonine
constant: false
initial amount: NaN
is: HMDB00167
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_362a08c1_f75e_4bf6_9061_fb4eb663386c
type: Species
constant: false
is: Q8N3T1
boundary condition: true
name: GALNTL2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:117248

metaM hs deg22 l
is: CHEBI:21338
initial concentration: 1.0
is: SBO:0000247
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
notes: FORMULA: C37H56NO35S CHARGE: -3
is: HMDB02704
constant: false
has only substance units: false
boundary condition: false
type: Species

metaM spmd e
is: HMDB01257
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
initial amount: NaN
is: CHEBI:57834
type: Species
boundary condition: false
is: C00315
is: SBO:0000247

metaR DHCR241r
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is described by: ECO:0000134
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
name: 24-dehydrocholesterol reductase [Precursor]
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
fast: false
reactant: MODEL1310110050#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110050#_a40433b5_7dc7_4aac_aaed_a5d22b5d912b
is: Q13630
constant: false
is encoded by: hsa:7264
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: TSTA3
boundary condition: true
initial concentration: NaN

metaR GLYBtm
kinetic law: MODEL1310110050#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
is described by: ECO:0000000
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
product: MODEL1310110050#
reactant: MODEL1310110050#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_d395cd95_663c_4194_bd47_a8a7a196fc1d
initial concentration: NaN
name: INPP5A
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q14642
boundary condition: true
is encoded by: hsa:3632

metaR NAGLCAly
product: MODEL1310110050#
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
type: Reaction
name: N-acetylglucosaminidase, lysosomal
reversible: false
is: SBO:0000176

metaM ascb L c
boundary condition: false
is: CHEBI:38290
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
initial amount: NaN
name: L-ascorbate
type: Species

metaR ST6GALNAC27
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
modifier: MODEL1310110050#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.7
fast: false
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
kinetic law: MODEL1310110050#

metaM odecoa r
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01322
is: CHEBI:57387
name: oleoyl-CoA(4-)
is: SBO:0000247
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
type: Species
initial amount: NaN

metaR EAFLATOXINte
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: xenobiotic transport
product: MODEL1310110050#

metaR r1374
reversible: false
name: EC:3.2.1.14
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
is described by: ECO:0000000

metaR KCC2t
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000269
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
type: Reaction
modifier: MODEL1310110050#
reversible: true
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110050#

metaM 2maacoa m
constant: false
boundary condition: false
name: 2-methylacetoacetyl-CoA(4-)
has only substance units: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species
is: HMDB01157
initial concentration: 1.0
is: CHEBI:57335
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_71284787_b4a0_4a1b_b1bc_7b9c6208e763
is encoded by: hsa:8813
type: Species
has part: Q86TM7
boundary condition: true
has part: O60762
is: SBO:0000297
constant: false
is encoded by: hsa:8818
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: DPM3:DPM1:DPM2
is encoded by: hsa:54344
has part: O94777

metaM mag hs c
is: CHEBI:16987
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
has only substance units: false
is: HMDB12130
type: Species
name: monoacylglycerol 2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_20301070_e755_4fce_85ea_aaf7cd245207
boundary condition: true
name: TPI1
has only substance units: false
initial amount: NaN
is: Q53HE2
is encoded by: hsa:7167
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaM glyb c
initial amount: NaN
name: glycine betaine
type: Species
initial concentration: 1.0
is: CHEBI:17750
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_c02b7cd1_0df8_4f5c_8dd7_ee465c5d2c0d
is encoded by: hsa:1841
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: DTYMK
boundary condition: true
type: Species
is: P23919
initial amount: NaN

metaR RE3566C
kinetic law: MODEL1310110050#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110050#
name: RE3566
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110050#

metaR DMHPTCRNte
type: Reaction
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
name: 2,6 dimethylheptanoyl carnitine transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
reactant: MODEL1310110050#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_eb3a3c4d_f254_43d9_b220_a1a39ecb0008
type: Species
is: SBO:0000252
boundary condition: true
name: INPP4A
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3631
constant: false
has only substance units: false
is: Q96PE3

metaM mag hs e
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:60479
is: SBO:0000247
initial concentration: 1.0
type: Species
name: monoacylglycerol 2
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

metaR PTDCAt
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110050#
fast: false
is described by: ECO:0000000
product: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_8e10bda3_99cd_4436_81fe_400c489a8254
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:84920
name: ALG10
is: SBO:0000252
constant: false
type: Species
is: Q5BKT4

http://identifiers.org/biomodels.db/MODEL1310110050#_9c135baa_5f94_42d1_84b2_40eccf5a5bdb
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: Q14442
has part: Q9BRB3
boundary condition: true
type: Species
has part: O94777
is encoded by: hsa:9091
is: SBO:0000297
is encoded by: hsa:5283
is encoded by: hsa:8818
has only substance units: false
initial amount: NaN
is encoded by: hsa:5277
initial concentration: NaN
constant: false
has part: Q92535
has part: B3KUV7
is encoded by: hsa:5279

metaM sbt D c
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
initial concentration: 1.0
name: D-glucitol
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:17924
is: HMDB00247
type: Species

metaR DHFtm
kinetic law: MODEL1310110050#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
name: dihydrofolate reversible mitochondrial transport
product: MODEL1310110050#
reactant: MODEL1310110050#

metaM f1p c
initial amount: NaN
is: HMDB01076
boundary condition: false
name: D-Fructose 1-phosphate
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
is: C01094
has only substance units: false
initial concentration: 1.0
is: CHEBI:18105

metaR r1375
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110050#
is: SBO:0000185
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
product: MODEL1310110050#
kinetic law: MODEL1310110050#

metaM CE5121 m
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
name: trans-3-decenoyl-CoA
is: CHEBI:57449

http://identifiers.org/biomodels.db/MODEL1310110050#_c22c8139_8ee0_48ad_88b1_7374d09f8ccd
type: Species
name: PLA2G1B
constant: false
is: P04054
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5319

metaR GGH 6DHFe
product: MODEL1310110050#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
modifier: MODEL1310110050#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_c488999e_ca8d_44b2_8422_b1bb89543f64
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI378339
name: _AI378339_1_m
type: Species
is: SBO:0000252
constant: false
has only substance units: false

metaR FRUt4
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
modifier: MODEL1310110050#
name: D-fructose transport via sodium cotransport

http://identifiers.org/biomodels.db/MODEL1310110050#_46669415_0bbe_486c_a7aa_667b0f042f60
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: VNN3:VNN2:VNN1
initial concentration: NaN
is encoded by: hsa:55350
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110050#_5cc257e6_9472_413b_86f4_597864d9ceac
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ALPPL2
is: P10696
is encoded by: hsa:251
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_6ba58fb6_18c8_4d53_86dd_7e1df9190d05
is encoded by: hsa:259230
boundary condition: true
has only substance units: false
name: SGMS1
type: Species
initial amount: NaN
constant: false
is: D3DWC4
is: SBO:0000252
initial concentration: NaN

metaM biliverd c
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
has only substance units: false
initial amount: NaN
is: HMDB01008
initial concentration: 1.0
constant: false
name: biliverdin(2-)
is: SBO:0000247
is: CHEBI:57991
type: Species
boundary condition: false

metaR MDH
modifier: MODEL1310110050#
is: SBO:0000176
type: Reaction
name: malate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.37
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:Biochemical
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
is described by: ECO:0000134
reversible: true

metaR r0698
fast: false
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
reversible: true
is: SBO:0000176
reactant: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.1.2.27
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:

metaM HC01406 m
name: 3-Oxooctanoyl-CoA
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:28264
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
has only substance units: false

metaM nrvnc e
is: HMDB02368
constant: false
is: CHEBI:32392
name: nervonate
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_934a2d8f_cfa0_42c1_bcd5_46eba2e46c5d
name: _AF080579_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AF080579
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_f2375423_3373_4653_92d3_74654d370820
boundary condition: true
is: Q308M7
initial amount: NaN
name: ENPP3
has only substance units: false
type: Species
is encoded by: hsa:5169
constant: false
initial concentration: NaN
is: SBO:0000252

metaM hs deg4 l
name: heparan sulfate, degradation product 4
is: CHEBI:16126
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12

metaM cs e deg3 l
notes: FORMULA: C37H53NO44S4 CHARGE: -6
boundary condition: false
initial amount: NaN
is: HMDB00127
is: CHEBI:15748
initial concentration: 1.0
constant: false
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_20dbba85_3b2d_472e_b31f_387a3f747000
initial amount: NaN
has only substance units: false
name: ESCO2
is: Q56NI9
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:157570
boundary condition: true
constant: false

metaM CE0693 m
name: 3-oxolaur-6-cis-enoyl-CoA
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB11123
type: Species
is: CHEBI:28387
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_09d47c13_41e8_4b11_95cb_194bf75605fd
constant: false
name: DLST
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1743
is: P36957
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM odecoa m
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:57387
is: HMDB01322
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false

metaM 4nph e
boundary condition: false
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
name: 4-nitrophenolate
constant: false
is: SBO:0000247
is: HMDB01232
has only substance units: false
is: CHEBI:57917
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_8e19efb5_ae20_4efd_8c36_19174e6f607f
is encoded by: hsa:1798
is: SBO:0000252
boundary condition: true
name: DPAGT1
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaM sbt D e
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: D-glucitol
is: HMDB00247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_065f5c5f_a638_4d28_90f5_e4790d4335cb
is: Q16678
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1545
name: CYP1B1
initial amount: NaN
type: Species

metaM ethamp r
boundary condition: false
is: CHEBI:58190
name: O-phosphonatoethanaminium(1-)
is: HMDB00224
type: Species
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110050#_68038232_c983_4a49_9b2f_b0b67d5c1b2d
name: ASNS
is: P08243
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:440
constant: false

metaM ksi pre28 g
initial concentration: 1.0
is: CHEBI:2504
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 28
is: HMDB06552
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9

metaR r0130
is described by: ECO:0000000
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
modifier: MODEL1310110050#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
type: Reaction

metaR r1377
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110050#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
product: MODEL1310110050#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110050#_36d54028_4dac_49aa_b3dc_752214dc5b2c
boundary condition: true
name: _AA576959_1_c
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AA576959
initial amount: NaN

metaM cholcoads x
type: Species
boundary condition: false
constant: false
is: CHEBI:27505
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: HMDB06889
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM frdp x
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
is: CHEBI:175763
is: HMDB00961
name: farnesyl pyrophosphate(3-)

metaM fpram c
boundary condition: false
is: CHEBI:58478
is: HMDB06211
is: C04640
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
initial amount: NaN

metaM fe2 e
initial concentration: 1.0
name: Fe2+
boundary condition: false
is: CHEBI:29033
is: HMDB00692
is: SBO:0000247
constant: false
is: C00023
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial amount: NaN
has only substance units: false
type: Species

metaR DNDPt33m
fast: false
name: dGDP transport via dUDP antiport
is: SBO:0000185
modifier: MODEL1310110050#
reversible: false
reactant: MODEL1310110050#
type: Reaction
kinetic law: MODEL1310110050#
is described by: ECO:0000269
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR UPPDC1
reactant: MODEL1310110050#
is described by: ECO:0000269
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
is: SBO:0000176
type: Reaction
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.1.1.37
fast: false
reversible: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_e34f5b4d_5094_446e_9d0b_9758f9463c52
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ALDH1A3
is: SBO:0000252
constant: false
is: P47895
type: Species
is encoded by: hsa:220

metaR r1378
is: SBO:0000176
reactant: MODEL1310110050#
type: Reaction
fast: false
product: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reversible: true
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
kinetic law: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_80de5ddc_4f35_41fa_afa9_071c28c9e622
boundary condition: true
initial amount: NaN
constant: false
is: P59796
initial concentration: NaN
has only substance units: false
name: GPX6
is: SBO:0000252
type: Species
is encoded by: hsa:257202

metaM nrvnc c
name: nervonate
initial amount: NaN
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB02368
constant: false
is: SBO:0000247
is: CHEBI:32392
boundary condition: false

metaM 4abutn e
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01080
name: 4-ammoniobutanal
is: CHEBI:58264
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR DURAD
name: dihydrouracil dehydrogenase (NADP)
kinetic law: MODEL1310110050#
reversible: true
fast: false
modifier: MODEL1310110050#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.3.1.2
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

http://identifiers.org/biomodels.db/MODEL1310110050#_5f6e5333_9fc9_4582_96bb_332c143f9ccf
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: DHCR24
type: Species
is: SBO:0000252
is: Q15392
is encoded by: hsa:1718

http://identifiers.org/biomodels.db/MODEL1310110050#_ec1bcc9f_4de9_491f_bfe5_7ca30eda0947
is encoded by: hsa:341947
type: Species
boundary condition: true
constant: false
name: COX8C
is: Q7Z4L0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM HC02023 r
boundary condition: false
initial concentration: 1.0
constant: false
name: Cholesterol-ester-ol
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
type: Species
has only substance units: false
is: CHEBI:46898

metaR r2408
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110050#_665e3609_2906_408f_be94_8205106cda03
has only substance units: false
name: _H45672_1_m
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:H45672
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110050#_35a9531a_4630_42d8_9f9d_95127330a20f
is: P22234
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:10606
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: PAICS

metaR FAOXC80
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
kinetic law: MODEL1310110050#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110050#
product: MODEL1310110050#
name: Beta oxidation of med/long chain fatty acid

metaR r1648
kinetic law: MODEL1310110050#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110050#
modifier: MODEL1310110050#

metaR PPItx
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110050#
is: SBO:0000185
name: Diphosphate transporter, peroxisome
reactant: MODEL1310110050#

metaM xolest2 hs c
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: cholesterol ester
is: CHEBI:17002
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110050#_aeecddaa_c755_45c0_bed7_08c0345b4ab6
boundary condition: true
constant: false
is encoded by: hsa:1544
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P05177
initial concentration: NaN
type: Species
name: CYP1A2

metaM prist x
initial amount: NaN
constant: false
is: HMDB00795
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
name: pristanic acid
type: Species
is: CHEBI:51340
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR CITt4 4
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
type: Reaction
product: MODEL1310110050#
reversible: true
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110050#
is described by: ECO:0000006

metaM 4nph c
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57917
name: 4-nitrophenolate
boundary condition: false
constant: false
is: HMDB01232
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870

metaR DDCRNe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_0a37bb02_bf9f_4caa_8087_628d682400a8
constant: false
boundary condition: true
name: NDUFB8
is: O95169
has only substance units: false
is encoded by: hsa:4714
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaM pe hs m
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16038

metaR UMPK4
kinetic law: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110050#
reactant: MODEL1310110050#
product: MODEL1310110050#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: UMP kinase (GTP)

http://identifiers.org/biomodels.db/MODEL1310110050#_48be6b43_5145_44b0_aebc_ea90920f6914
has only substance units: false
initial amount: NaN
is encoded by: hsa:10476
constant: false
initial concentration: NaN
boundary condition: true
is: A0PJH2
name: ATP5H
type: Species
is: SBO:0000252

metaR r0549
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.6.99.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.1.1.17
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
type: Reaction
kinetic law: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: true
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19

http://identifiers.org/biomodels.db/MODEL1310110050#_3777e594_313a_44f6_adc3_784f4cc5699d
boundary condition: true
type: Species
name: B3GNT8
is encoded by: hsa:374907
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM frdp r
is: CHEBI:175763
constant: false
name: Farnesyl diphosphate
type: Species
is: C00448
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR ACACtx
is described by: ECO:0000000
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
name: acetoacetate intracellular transport unknown mechanism
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110050#

metaR r1649
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110050#
type: Reaction

metaR DINt
is: SBO:0000185
name: deoxyinosine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110050#
type: Reaction
fast: false
reactant: MODEL1310110050#
product: MODEL1310110050#

metaM dolp L r
boundary condition: false
is: CHEBI:57683
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
constant: false
initial concentration: 1.0
name: dolichyl phosphate(2-)
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110050#_ef5dbfcb_0a37_46d4_b97e_8fc5e6f0d86a
initial concentration: NaN
name: HSD17B10
is: SBO:0000252
is: Q99714
boundary condition: true
type: Species
is encoded by: hsa:3028
constant: false
has only substance units: false
initial amount: NaN

metaR UMPK5
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110050#
is: SBO:0000176
product: MODEL1310110050#
name: UMP kinase (dATP)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_38d98a02_deef_4f3e_bf77_74fdd3c80bdb
has only substance units: false
initial concentration: NaN
name: SMPD3
boundary condition: true
is: Q9NY59
is encoded by: hsa:55512
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaR MI14PP
type: Reaction
fast: false
name: inositol-1,4-bisphosphate 1-phosphatase
reversible: false
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.57
is described by: ECO:0000269
product: MODEL1310110050#
reactant: MODEL1310110050#
is: SBO:0000176
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#

metaR r0287
reversible: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000000
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
fast: false
is: SBO:0000176

metaM pmtcoa r
is: C00154
initial amount: NaN
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
constant: false
boundary condition: false
is: HMDB01338
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM HC00822 l
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:28681
name: Chitobiose
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_81390e54_015a_48e2_9ec4_e71bb5e68db7
initial concentration: NaN
is encoded by: hsa:83549
boundary condition: true
name: UCK1
constant: false
initial amount: NaN
is: Q5JT09
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_31ad0fb4_7243_4aff_a0c4_d6d7e32f07fd
initial concentration: NaN
type: Species
name: _AI926493_1_c
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI926493
is: SBO:0000252
constant: false

metaR r1646
kinetic law: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110050#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110050#
type: Reaction
modifier: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_49c199af_9551_42c0_8d1c_b29be819d464
is encoded by: hsa:126
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: ADH1C
is: SBO:0000252
is: P00326

http://identifiers.org/biomodels.db/MODEL1310110050#_f6996b22_454d_462c_bb97_4c0c90814374
name: DYLX2
type: Species
is encoded by: hsa:9856
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: F5H123
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110050#_55a83a54_3c18_4259_9436_948183e7bd77
is encoded by: hsa:LOC728997
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _LOC728997_1_c
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_c40e3b3f_619c_4de6_a52f_67442f21b96d
boundary condition: true
constant: false
name: OGDH
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q02218
is encoded by: hsa:4967
type: Species
has only substance units: false

metaM glyb e
is: HMDB00043
is: CHEBI:17750
name: glycine betaine
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_43852a0c_4606_450c_a8cc_43ab09584df0
boundary condition: true
is: Q8WZ48
has only substance units: false
constant: false
name: CPT1A
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1374
initial concentration: NaN

metaM andrstandn r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial amount: NaN
is: SBO:0000247
name: 5alpha-androstane-3,17-dione
constant: false
is: HMDB00899
is: CHEBI:15994
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR GLCAASE9ly
product: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
is: SBO:0000176
reactant: MODEL1310110050#
type: Reaction
name: beta-glucuronidase, lysosomal

metaR UMPK2
reversible: true
modifier: MODEL1310110050#
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110050#
fast: false
kinetic law: MODEL1310110050#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (CTP)
is: SBO:0000176
is described by: ECO:0000269

metaR r1792
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110050#
reactant: MODEL1310110050#
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR r1647
type: Reaction
fast: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110050#
is described by: ECO:0000000
modifier: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110050#_a000bea9_3633_416f_95c0_7eb9a3e64c5a
initial amount: NaN
type: Species
boundary condition: true
is: B3KQ63
constant: false
is: SBO:0000252
has only substance units: false
name: HPD
is encoded by: hsa:3242
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_6e975780_dc8d_4ea5_af1c_1911f7ef2d5c
boundary condition: true
initial concentration: NaN
is encoded by: hsa:516
is: SBO:0000252
name: ATP5G1
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: P05496

metaR RE2069C
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
fast: false
product: MODEL1310110050#
type: Reaction
name: RE2069
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_2b1c652f_035b_472f_9ed1_ee9acf725b63
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI971023
constant: false
type: Species
name: _AI971023_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR GLACter
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
reactant: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110050#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_3f0d419c_e798_43af_89cd_c23e28d60267
initial concentration: NaN
has part: Q92569
is encoded by: hsa:5293
name: PIK3CD:PIK3R3
is encoded by: hsa:8503
boundary condition: true
has only substance units: false
has part: A7E2E0
constant: false
is: SBO:0000297
initial amount: NaN
type: Species

metaR NDP3ex
kinetic law: MODEL1310110050#
type: Reaction
is described by: ECO:0000269
name: nucleoside-diphosphatase (GDP), extracellular
is: SBO:0000176
reactant: MODEL1310110050#
reversible: false
fast: false
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD

metaR UMPK3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: true
name: UMP kinase (UTP)
reactant: MODEL1310110050#
product: MODEL1310110050#
is described by: ECO:0000269

metaM 6hoxmelatn c
is: HMDB04081
is: C05643
type: Species
name: 6-Hydroxymelatonin
is: http://identifiers.org/pubchem.compound/7954
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM pe hs r
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16038
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247

metaR AIRCr
name: phosphoribosylaminoimidazole carboxylase
product: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.3.2.6
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#

metaR r1644
is: SBO:0000185
modifier: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110050#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
type: Reaction
fast: false

metaM itp n
initial concentration: 1.0
is: CHEBI:57614
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00189
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_c508b8c6_77a5_4f58_a306_c9b8e1f4760f
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: DGAT1
is: O75907
boundary condition: true
constant: false
is encoded by: hsa:8694
type: Species
initial concentration: NaN

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_80d2c42d_61a6_4f01_b896_ce5cdac5e6d6
name: GLUL
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2752
is: P15104
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_5c68e8e3_9874_4450_b0e7_abdf432962bf
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: CHKB
constant: false
initial amount: NaN
has only substance units: false
is: Q9Y259
is encoded by: hsa:1120

metaR PRFGS
is version of: http://identifiers.org/ec-code/6.3.5.3
modifier: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110050#
type: Reaction
reversible: false
is described by: ECO:0000269
name: phosphoribosylformylglycinamidine synthase
product: MODEL1310110050#
is: SBO:0000176

metaR G14T13g
is described by: ECO:0000000
reactant: MODEL1310110050#
type: Reaction
reversible: false
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110050#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110050#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110050#_f138cd7c_641f_47b2_a05c_c423617de754
has only substance units: false
is encoded by: hsa:6547
name: SLC8A3
type: Species
is: SBO:0000252
boundary condition: true
is: B3KU59
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_ddccc1ae_9b52_46dd_a7d7_8d379cef1225
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6547
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC8A3

metaR r1645
kinetic law: MODEL1310110050#
fast: false
product: MODEL1310110050#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110050#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110050#
type: Reaction

metaR r2405
is: SBO:0000185
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110050#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110050#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_9e7804d7_66da_4832_8faf_2531696ef41f
boundary condition: true
is encoded by: hsa:517
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: ATP5G2
type: Species
is: SBO:0000252

metaR TETDECE1CRNe
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_2bf3d9a0_830f_405f_a443_a1958af13515
boundary condition: true
is encoded by: hsa:123041
constant: false
initial amount: NaN
name: SLC24A4
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM abt c
constant: false
name: L-arabinitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
is: HMDB01851
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:18403

metaR FERO
reversible: false
reactant: MODEL1310110050#
fast: false
product: MODEL1310110050#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
name: ferroxidase
kinetic law: MODEL1310110050#
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

metaR RETNt
name: retinoic acid transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110050#
is: SBO:0000185
reactant: MODEL1310110050#
reversible: true
type: Reaction
kinetic law: MODEL1310110050#

metaR S6T12g
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
is described by: ECO:0000000
product: MODEL1310110050#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110050#
is: SBO:0000176
fast: false

metaM ascb L e
initial amount: NaN
type: Species
is: HMDB00044
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: CHEBI:38290
name: L-ascorbate
boundary condition: false
is: SBO:0000247

metaR HACD1m
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
product: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)

metaR PAIL HStn
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110050#
name: phosphatidylinositol nuclear transport (diffusion)
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM HC02216 e
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
is: CHEBI:28922
has only substance units: false
name: prostaglandin-f2beta
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR PA HStn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110050#
name: phosphatidate transport, nuclear
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
fast: false
is: SBO:0000185
reversible: true

metaR C102CPT1
kinetic law: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR r1642
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110050#
is: SBO:0000185
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110050#
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false

metaR DUMPtn
type: Reaction
name: dUMP nuclear transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
product: MODEL1310110050#
reactant: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_2b1bf7a6_4c0e_4bd7_ad1c_e90a80a3bd28
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5331
is: SBO:0000252
initial amount: NaN
is: G5E960
name: PLCB3
boundary condition: true
initial concentration: NaN

metaM atp c
is: C00002
type: Species
name: ATP(4-)
is: CHEBI:30616
is: SBO:0000247
initial amount: NaN
is: HMDB00538
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR r0283
is version of: http://identifiers.org/ec-code/2.7.1.157
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.6
name: L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110050#
product: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (AA676725.1) or (196951.1) or (2584.1) or (2585.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 6.3.2.11 Confidence Level: 0 AUTHORS: PMID:448355,PMID:487087 NOTES:
kinetic law: MODEL1310110050#

metaM andrstrn r
type: Species
boundary condition: false
is: HMDB00031
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: androsterone
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: SBO:0000247
is: CHEBI:16032

metaR UMPK6
reversible: true
reactant: MODEL1310110050#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110050#
product: MODEL1310110050#
name: UMP kinase (dCTP)
is described by: ECO:0000269
modifier: MODEL1310110050#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110050#_8ca10665_c604_447d_9061_eb6b7cb30007
has only substance units: false
type: Species
name: _AI435857_1_x
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI435857
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_a82562bc_e862_43c3_afcf_6e78a29007f2
initial amount: NaN
is encoded by: hsa:728226
initial concentration: NaN
name: _728226_1_e
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110050#_e7cc0d8c_1b2d_42d7_8a64_612995bfc7e9
is encoded by: hsa:2618
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: GART
is: SBO:0000252
initial amount: NaN
constant: false
is: P22102

http://identifiers.org/biomodels.db/MODEL1310110050#_129c8a23_3eef_4936_9f4f_fa9293d30996
is: SBO:0000252
constant: false
name: NDUFB6
type: Species
has only substance units: false
is: O95139
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:4712

http://identifiers.org/biomodels.db/MODEL1310110050#_0b8884f6_1eb7_4768_a4d4_472f11d62ad2
initial concentration: NaN
is: O00746
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: NME4
initial amount: NaN
has only substance units: false
is encoded by: hsa:4833

metaM 4abutn m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
is: CHEBI:58264
type: Species
name: 4-ammoniobutanal

metaR FAOXC200180m
reactant: MODEL1310110050#
kinetic law: MODEL1310110050#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
product: MODEL1310110050#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110050#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110050#_6d3b3f43_b9dd_4073_8287_5f80672899a9
name: CA13
is encoded by: hsa:377677
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: Q8N1Q1

metaR GDPtg
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
reversible: true
kinetic law: MODEL1310110050#
product: MODEL1310110050#
fast: false
name: GDP intracellular transport
is: SBO:0000185
reactant: MODEL1310110050#

metaR r1796
product: MODEL1310110050#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110050#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction

metaR r1643
reactant: MODEL1310110050#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110050#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110050#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110050#

http://identifiers.org/biomodels.db/MODEL1310110050#_3fe9d291_d2a3_490c_a7b3_07dd6f2376c6
has only substance units: false
type: Species
constant: false
name: NDUFB4
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4710
is: O95168

metaR UMPK7
type: Reaction
reversible: true
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110050#
product: MODEL1310110050#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110050#
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase (dGTP)

http://identifiers.org/biomodels.db/MODEL1310110050#_c4eaba2a_eba5_4852_9553_38ab50f35e7d
has only substance units: false
initial concentration: NaN
is encoded by: hsa:C7orf24
name: _C7orf24_1_m
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110050#_0b0ae57b_cec8_4547_8457_91e43372d4a7
boundary condition: true
name: GALC
initial concentration: NaN
is: P54803
is encoded by: hsa:2581
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110050#_8d57754b_fdcb_4ef9_b380_c7ea921bbc80
has only substance units: false
boundary condition: true
type: Species
name: _AA664770_1_m
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:AA664770

metaM tetdec2crn e
type: Species
initial concentration: 1.0
is: HMDB05066
notes: FORMULA: C21H37NO4 CHARGE: 0
initial amount: NaN
has only substance units: false
name: tetradecadienoyl carnitine
constant: false
is: SBO:0000247
boundary condition: false

metaM abt e
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01851
is: CHEBI:18403
name: L-arabinitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false

metaM hdca c
has only substance units: false
type: Species
is: HMDB00220
is: CHEBI:7896
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate
initial amount: NaN
constant: false

metaM lnlccrn m
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB06469
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false
name: Linoleyl carnitine
type: Species

metaM phyt c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: SBO:0000247
has only substance units: false
is: CHEBI:37257
constant: false
boundary condition: false
type: Species
name: phytanate
is: HMDB00801

http://identifiers.org/biomodels.db/MODEL1310110050#_d074f7a1_d060_4c0d_9eda_ab1dda6ec498
boundary condition: true
type: Species
is: O75521
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:10455
name: ECI2
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110050#_a1bd7627_7811_4d27_9f96_b87daf0101fd
name: SLC25A10
boundary condition: true
is encoded by: hsa:1468
is: SBO:0000252
initial amount: NaN
is: Q9UBX3
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaM cspg a l
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: CHEBI:36005
initial concentration: 1.0
is: HMDB02183
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaR r2103
modifier: MODEL1310110050#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110050#
fast: false
reactant: MODEL1310110050#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110050#

metaM 3hibutcoa m
has only substance units: false
name: (S)-3-Hydroxyisobutyryl-CoA
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247
is: CHEBI:28259
constant: false
is: HMDB01052
type: Species
boundary condition: false

metaM ocdececrn c
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
is: SBO:0000247
name: 11-octadecenoyl carnitine
constant: false
initial amount: NaN

metaM 3hddcoa c
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
is: HMDB00623
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR FADH2tru
reversible: false
product: MODEL1310110050#
kinetic law: MODEL1310110050#
name: FADH2 transporter, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110050#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

metaM cpppg3 c
is: SBO:0000247
is: C03263
name: Coproporphyrinogen III
is: HMDB01261
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57309
constant: false
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263

metaM adp n
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
initial amount: NaN
has only substance units: false
name: ADP(3-)
is: SBO:0000247
is: HMDB01341

metaR r0575
product: MODEL1310110050#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
fast: false
reversible: true
modifier: MODEL1310110050#
kinetic law: MODEL1310110050#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reactant: MODEL1310110050#
type: Reaction

metaR r2104
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110050#
modifier: MODEL1310110050#
reactant: MODEL1310110050#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110050#
reversible: true
fast: false
type: Reaction

metaR r0226
reactant: MODEL1310110050#
type: Reaction
fast: false
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
kinetic law: MODEL1310110050#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110050#
modifier: MODEL1310110050#
reversible: false

metaM hdca e
type: Species
is: HMDB00220
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
boundary condition: false
initial amount: NaN
constant: false
is: C00249
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110050#_95c12bee_5e5d_4de8_bcd2_7eb21b8b5e42
has only substance units: false
constant: false
is encoded by: hsa:57379
is: SBO:0000252
name: AICDA
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: Q546Y9

metaR URCN
kinetic law: MODEL1310110050#
name: URCN
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110050#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110050#
is version of: http://identifiers.org/ec-code/4.2.1.49
reversible: false
reactant: MODEL1310110050#
is described by: ECO:0000269