metaR CO2ter
is: SBO:0000185
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: CO2 endoplasmic reticular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110049#
reversible: true
type: Reaction

metaR G6PPer
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
name: glucose-6-phosphate phosphatase, edoplasmic reticular
is: SBO:0000176
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.9
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_6bfceb36_87e5_48b7_b8c0_22dc211eea03
has only substance units: false
name: ATP8A1
type: Species
is: Q9Y2Q0
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10396
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_fb068fa0_92e7_4321_8d8f_dfda411106a2
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is: A8K596
is encoded by: hsa:1757
has only substance units: false
name: SARDH
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_d7dd7b51_a03d_4170_bd13_4a0442a63e97
is: O43678
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: NDUFA2
initial amount: NaN
is encoded by: hsa:4695
has only substance units: false
is: SBO:0000252

metaM mi3p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
is: CHEBI:58401
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 1D-myo-inositol 3-phosphate(2-)
type: Species
is: HMDB06814
boundary condition: false

metaR r2116
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110049#
modifier: MODEL1310110049#

metaR GDPtg
fast: false
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
name: GDP intracellular transport
is described by: ECO:0000000
reversible: true

metaR r1816
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110049#
name: Y+LAT2 Utilized transport

metaR AG13T10g
product: MODEL1310110049#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaM retinal 11 cis c
name: 11-cis-retinal
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
has only substance units: false
is: CHEBI:16066
is: HMDB02152
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_7b65d7c0_0cbb_48aa_92b1_8d308d72acb0
constant: false
initial concentration: NaN
type: Species
is: Q92781
name: RDH5
boundary condition: true
is encoded by: hsa:5959
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_aca2e6fc_9355_40dc_8103_d2efb5f9d845
initial amount: NaN
initial concentration: NaN
name: SLC27A2
type: Species
has only substance units: false
is: O14975
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:11001

http://identifiers.org/biomodels.db/MODEL1310110049#_8eb4f54b_9ad5_4e48_beb7_23aa2b7d5057
is encoded by: hsa:3295
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: E9PB82
has only substance units: false
initial amount: NaN
name: HSD17B4
constant: false
type: Species

metaR r0451
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: false
type: Reaction
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is: SBO:0000176

metaR UAG2EMAi
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110049#
is described by: ECO:0000269
reactant: MODEL1310110049#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
reversible: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
type: Reaction
fast: false

metaR r0170
modifier: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110049#
type: Reaction
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21

metaM CE5117 m
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00127
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
boundary condition: false
is: CHEBI:15748
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA

metaM o2s m
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:18421
initial amount: NaN
type: Species
name: Superoxide anion
is: C00704
is: SBO:0000247
is: HMDB02168
boundary condition: false

metaR r2117
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR DM Lcystin
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR BPNT
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
kinetic law: MODEL1310110049#
name: 3',5'-bisphosphate nucleotidase
reactant: MODEL1310110049#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c3e3b15e_ca44_458e_a1dc_4a9242de9471
has only substance units: false
name: VNN2
initial amount: NaN
constant: false
is: O95498
initial concentration: NaN
type: Species
is encoded by: hsa:8875
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_8f4eb665_8489_4b29_8b53_77d8d142a748
constant: false
initial amount: NaN
name: DDC
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q53Y41
has only substance units: false
boundary condition: true
is encoded by: hsa:1644

metaR NACASPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
reversible: false
fast: false

metaM dlnlcgcoa r
initial concentration: 1.0
is: CHEBI:27979
constant: false
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
is: C03595

http://identifiers.org/biomodels.db/MODEL1310110049#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
kinetic law: MODEL1310110049#
name: blood group intracellular transport
reactant: MODEL1310110049#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_72961f34_67d0_43d6_bd2b_64a13df3b231
name: DPM3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54344
boundary condition: true
type: Species
constant: false
is: Q9P2X0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_7510b335_211c_41b8_8d2b_b398ea60eff9
initial amount: NaN
type: Species
constant: false
name: TREH
is encoded by: hsa:11181
initial concentration: NaN
is: O43280
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM chito2pdol L c
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
is: HMDB01196
is: CHEBI:12427
boundary condition: false
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1

metaM ksi deg11 l
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 11
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C180H289N12O158S9 CHARGE: -9

http://identifiers.org/biomodels.db/MODEL1310110049#_bd9dfcc4_7632_4313_9ed0_b72c98ee0d58
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC25A26
is encoded by: hsa:115286
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaR APOC LYS BTNPm
product: MODEL1310110049#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110049#
name: proteolysis of apoC-Lys-btn, mitochondrial
fast: false

metaR r0450
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
product: MODEL1310110049#
reversible: true
fast: false
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000176

metaR r2114
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110049#
fast: false

metaR C226CPT1
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
reversible: false
modifier: MODEL1310110049#
name: carnitine C22:6 transferase
reactant: MODEL1310110049#
is described by: ECO:0000000

metaR DNDPt23m
product: MODEL1310110049#
name: dTDP transport via dGTP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
fast: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reversible: false

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR r1967
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110049#
is described by: ECO:0000000

metaR DOLMANP Uter
type: Reaction
is described by: ECO:0000000
name: dolichol-phosphate mannose flippase (uterus)
kinetic law: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
fast: false

metaR PPM
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: true
modifier: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
is described by: ECO:0000000
name: phosphopentomutase
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:

metaR r2115
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000000

metaR r1819
modifier: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
kinetic law: MODEL1310110049#

metaM lnlncg e
has only substance units: false
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: SBO:0000247
constant: false
is: CHEBI:32391
initial concentration: 1.0
boundary condition: false
is: HMDB03073
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_1437a02a_1104_462b_80db_55753cd9d596
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR PROSTGH2t
is: SBO:0000185
name: Prostaglandin H2 transport
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_7637c570_4393_460c_b75c_c009667ffec8
name: UCK2
initial concentration: NaN
type: Species
is encoded by: hsa:7371
is: SBO:0000252
is: Q9BZX2
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM trdrd c
has only substance units: false
initial concentration: 1.0
name: Reduced thioredoxin
is: SBO:0000247
type: Species
is: C00342
is: CHEBI:15967
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaR r2330
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110049#

metaR r0153
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
modifier: MODEL1310110049#
name: CTP:pyruvate O2-phosphotransferase EC:2.7.1.40
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_c77e86ae_758c_493f_9118_ea03e3f0d387
is: SBO:0000252
boundary condition: true
type: Species
is: P17812
constant: false
initial amount: NaN
has only substance units: false
name: CTPS1
initial concentration: NaN
is encoded by: hsa:1503

metaR RE1517M
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000176
name: RE1517
reactant: MODEL1310110049#
fast: false
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
modifier: MODEL1310110049#

metaR CYOR u10m
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reactant: MODEL1310110049#
name: ubiquinol-6 cytochrome c reductase, Complex III
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110049#
is described by: ECO:0000134
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110049#

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_900ba781_e354_4219_9105_bf4fe74e50f7
initial concentration: NaN
is encoded by: hsa:8528
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: DDO
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_3bb3e2d3_1094_4543_92a0_b8cb5adc1c60
is: H0UI06
has only substance units: false
is: SBO:0000252
name: COX7A2
constant: false
initial concentration: NaN
is encoded by: hsa:1347
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_0544aa26_3728_4e73_804b_b4e576572113
is: P15531
name: NME1
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4830
type: Species

metaM glu5sa m
initial concentration: 1.0
name: L-Glutamate 5-semialdehyde
is: CHEBI:17232
type: Species
constant: false
is: HMDB02104
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: C01165
initial amount: NaN
boundary condition: false
has only substance units: false

metaR C226CPT2
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000
name: C226 transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
type: Reaction
is: SBO:0000176

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM arachd c
initial concentration: 1.0
is: CHEBI:32395
is: SBO:0000247
type: Species
boundary condition: false
name: arachidonate
is: HMDB01043
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

metaR r2331
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110049#_748a91de_021e_48bc_a837_9a1e40effa8f
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6515
name: SLC2A3
is: P11169
initial concentration: NaN
type: Species
has only substance units: false

metaM lnlncg c
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:32391
is: HMDB03073
type: Species
has only substance units: false

metaM CE5586 c
type: Species
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
is: CHEBI:58732
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
boundary condition: false
has only substance units: false

metaR LINOFATPtc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_04dcdd5e_500a_402c_b164_2792c8713241
is: P49189
type: Species
name: ALDH9A1
has only substance units: false
is encoded by: hsa:223
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

metaR r2118
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_74a90a0c_367a_45be_8d66_0d534e12ff60
initial amount: NaN
is encoded by: hsa:1841
is: SBO:0000252
type: Species
name: DTYMK
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: P23919

metaM utp m
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
name: UTP(4-)
is: CHEBI:46398

http://identifiers.org/biomodels.db/MODEL1310110049#_7813d421_6e24_43ca_912a_124489150ccd
boundary condition: true
has only substance units: false
name: DPAGT1
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: Q9H3H5
is encoded by: hsa:1798
initial concentration: NaN

metaR r2017
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
reversible: false
fast: false

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaM accoa r
type: Species
boundary condition: false
is: HMDB01206
constant: false
initial amount: NaN
name: acetyl-CoA(4-)
is: CHEBI:57288
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_5afeedab_687a_4019_9610_836b9cbde4fd
type: Species
is encoded by: hsa:35
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: P16219
name: ACADS
boundary condition: true
is: SBO:0000252

metaM ppi x
type: Species
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: CHEBI:33019
name: Diphosphate
initial concentration: 1.0
is: C00013
has only substance units: false
constant: false
boundary condition: false
is: HMDB00250

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_b0744091_581d_4f43_b03a_d16987eb4a79
initial concentration: NaN
type: Species
is encoded by: hsa:80025
is: SBO:0000252
name: PANK2
boundary condition: true
constant: false
initial amount: NaN
is: Q6P1K9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_b15b8312_f9f9_4654_b4f8_73c781866dd2
constant: false
is: SBO:0000252
name: _H17063_1_m
is encoded by: hsa:H17063
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_7888dc05_4534_4976_9a6a_896b1bc0d8a9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI990637
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: _AI990637_1_x
constant: false

metaR ABO5g
modifier: MODEL1310110049#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reversible: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.37
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ

metaM thf c
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57453

http://identifiers.org/biomodels.db/MODEL1310110049#_4c6fa882_5531_4340_b923_a507b8d07f49
name: _X63359_1_c
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:X63359
has only substance units: false
boundary condition: true

metaR UDPDOLPT U
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.117
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
reversible: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
product: MODEL1310110049#
is: SBO:0000176

metaM utp n
is: SBO:0000247
has only substance units: false
is: HMDB00285
name: UTP(4-)
is: CHEBI:46398
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_03f57a7b_7dac_455c_a3ce_541401c10b7d
is: Q5QPH3
is encoded by: hsa:55902
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ACSS2
initial concentration: NaN
boundary condition: true
constant: false

metaM mmcoa R m
is: HMDB01269
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
name: (R)-methylmalonyl-CoA(5-)
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57326
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_fcf704bf_8f34_42eb_9486_9ed9cfbab884
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O15496
initial concentration: NaN
name: PLA2G10
is encoded by: hsa:8399
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_4b47ffba_6150_4f3c_bb07_adfcd12087b0
is encoded by: hsa:80308
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: FLAD1

metaR TYRt
is described by: ECO:0000269
kinetic law: MODEL1310110049#
name: L-tyrosine transport
modifier: MODEL1310110049#
fast: false
reversible: true
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110049#
is: SBO:0000185

metaR DM dsT antigen g
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM o2s e
name: superoxide
is: HMDB02168
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: CHEBI:18421
initial amount: NaN
type: Species

metaM ppi r
initial amount: NaN
is: C00013
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00250
is: CHEBI:33019
name: Diphosphate

metaM accoa m
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01206
name: Acetyl-CoA
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: CHEBI:57288
has only substance units: false

metaM thcholstoic m
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:18402
is: HMDB03873
type: Species
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaM cs c deg3 l
is: CHEBI:15748
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00127
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
notes: FORMULA: C31H48NO32S2 CHARGE: -3

metaR CYSTHRNaEx
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)

metaR BTNPL
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.3.4.10
name: holocarboxylase synthestase (biotin protein ligase)
modifier: MODEL1310110049#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reversible: false
type: Reaction

metaR ACNACNGALGBSIDEtg
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: acnacngalgbside hs intracellular transport
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_02880df2_6950_41c7_8cd0_2dad30aa41e0
name: GPX3
is: P22352
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:2878
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM accoa n
is: CHEBI:57288
initial amount: NaN
name: acetyl-CoA(4-)
is: HMDB01206
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247

metaR GLCt4
fast: false
is: SBO:0000185
modifier: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
type: Reaction
name: glucose transport via sodium symport
is described by: ECO:0000269
product: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_36778af2_93d3_4784_85b8_f7b7a4b04cfd
has part: Q99519
has part: P34059
initial concentration: NaN
name: GALNS:GLB1:NEU1:CTSA
is encoded by: hsa:2720
is encoded by: hsa:4758
constant: false
has part: P10619
has part: P16278
type: Species
is encoded by: hsa:5476
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:2588
has only substance units: false

metaM fadh2 r
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: FADH2(2-)
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01197

http://identifiers.org/biomodels.db/MODEL1310110049#_22a8d84b_fc7d_4062_adcd_57020d52a0ad
name: SLC26A9
is: B3KXK1
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:115019
boundary condition: true
initial amount: NaN
constant: false

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM coa r
is: CHEBI:57287
name: Coenzyme A
initial concentration: 1.0
constant: false
type: Species
is: HMDB01423
has only substance units: false
is: SBO:0000247
is: C00010
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM o2s c
initial amount: NaN
is: HMDB02168
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: superoxide
is: CHEBI:18421
type: Species

metaM succoa x
is: SBO:0000247
name: Succinyl-CoA
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB01022

metaR C14STRr
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.70
name: C-14 sterol reductase
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_15f288d6_14bd_4e03_8c07_ba72bb94e9b4
is encoded by: hsa:8034
has only substance units: false
name: SLC25A16
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P16260

metaM hdcea c
is: HMDB03229
name: Hexadecenoate (n-C16:1)
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
type: Species
is: CHEBI:32372

metaR GLCAASE8ly
name: beta-glucuronidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#

metaM ksii core2 deg3 l
initial amount: NaN
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
constant: false
type: Species
has only substance units: false
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 3

metaM coa x
is: CHEBI:57287
constant: false
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
has only substance units: false
is: C00010
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Coenzyme A
is: HMDB01423

metaR r0456
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113

metaR PLA2 2e
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.4
name: phospholipase A2
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
reactant: MODEL1310110049#

metaM ppi m
is: HMDB00250
has only substance units: false
is: SBO:0000247
name: Diphosphate
boundary condition: false
is: CHEBI:33019
initial amount: NaN
is: C00013
constant: false
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0

metaR LYStip
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
name: L-lysine transport, peroxisomal (irreversible)
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
type: Reaction
reversible: false

metaR MTAP
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.2.28
is: SBO:0000176
fast: false
name: 5'-methylthioadenosine phosphorylase
notes: GENE_ASSOCIATION: (4507.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.4.2.28 Confidence Level: 4 AUTHORS: PMID:16000004,PMID:2543672,PMID:3091600 NOTES:
type: Reaction
is described by: ECO:0000269

metaM utp c
initial amount: NaN
type: Species
has only substance units: false
name: UTP
is: HMDB00285
constant: false
initial concentration: 1.0
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
is: SBO:0000247
is: C00075

metaM hxan c
name: Hypoxanthine
constant: false
has only substance units: false
boundary condition: false
is: C00262
is: CHEBI:17368
type: Species
initial concentration: 1.0
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: HMDB00157
initial amount: NaN
is: SBO:0000247

metaR BUTt2r
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is: SBO:0000185
name: Butyrate transport via proton symport, reversible
reversible: true
fast: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#

metaM fadh2 m
is: SBO:0000247
type: Species
is: CHEBI:58307
constant: false
boundary condition: false
is: HMDB01197
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
initial concentration: 1.0
name: Flavin adenine dinucleotide reduced
is: C01352
has only substance units: false

metaR UGLT
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110049#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD

metaM thf m
type: Species
is: SBO:0000247
constant: false
name: 5,6,7,8-Tetrahydrofolate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101
is: CHEBI:57453
has only substance units: false
is: HMDB01846

http://identifiers.org/biomodels.db/MODEL1310110049#_59d7c50d_d4b1_40a6_a870_debd0899cdd0
is: SBO:0000252
is encoded by: hsa:28976
has only substance units: false
initial amount: NaN
type: Species
is: Q9H845
constant: false
boundary condition: true
initial concentration: NaN
name: ACAD9

http://identifiers.org/biomodels.db/MODEL1310110049#_611c3940_0f5e_4310_8e33_7bc9ee9afdcc
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: _AD000092_1_c
is encoded by: hsa:AD000092
is: SBO:0000252
has only substance units: false

metaM ppi n
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:33019
name: diphosphate(3-)
initial amount: NaN
constant: false
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
is: HMDB00250
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d8f86861_b3f1_48cb_aaa5_fe234aa06287
is: SBO:0000252
is: P00813
boundary condition: true
name: ADA
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:100

http://identifiers.org/biomodels.db/MODEL1310110049#_8e5bf7f8_5837_4aeb_b8f1_d35c4ccb681d
boundary condition: true
is: SBO:0000252
is encoded by: hsa:587
is: O15382
initial amount: NaN
initial concentration: NaN
type: Species
name: BCAT2
has only substance units: false
constant: false

metaM ahdt e
is: SBO:0000247
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
is: CHEBI:58462
type: Species
is: HMDB00980
constant: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM ksi pre7 g
is: C00130
initial amount: NaN
constant: false
is: CHEBI:58053
is: HMDB00175
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 7
notes: FORMULA: C115H187N8O85SX CHARGE: -2

metaM hxan e
is: HMDB00157
name: hypoxanthine
is: CHEBI:17368
is: SBO:0000247
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR RETI3
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES:IT
reactant: MODEL1310110049#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: retinol isomerase (13-cis)
type: Reaction
product: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#

metaM utp e
is: HMDB00285
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
boundary condition: false
type: Species
is: CHEBI:46398
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_0677c490_92a3_4b89_9819_3d252fc57ab0
is: B3KMA6
is encoded by: hsa:2181
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: ACSL3
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM c8dc x
type: Species
name: suberyl carnitine
initial amount: NaN
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: C08260
initial concentration: 1.0
is: HMDB00672

metaR C4CRNCPT2
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM galgbside hs g
has only substance units: false
boundary condition: false
name: galactosylgloboside
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:18259
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 3hmbcoa m
is: HMDB01356
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57312
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
boundary condition: false
constant: false
has only substance units: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
initial concentration: 1.0

metaR RE1573M
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
name: RE1573
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
type: Reaction

metaM malcoa r
is: SBO:0000247
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
type: Species
initial amount: NaN
is: CHEBI:57384
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR RETI1
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
type: Reaction
name: retinol isomerase (11-cis)
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true

metaR RE2999M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110049#
reversible: true
is described by: ECO:0000000
fast: false
name: RE2999
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
kinetic law: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.3.3.8

metaM pro L m
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
name: L-proline
is: CHEBI:17203
initial amount: NaN

metaR r1810
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reversible: false
modifier: MODEL1310110049#
is described by: ECO:0000000

metaR LSTO1r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
name: Lathosterol oxidase
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.14.21.6

http://identifiers.org/biomodels.db/MODEL1310110049#_fdfe096c_afd5_4aa6_be05_136ecfd32240
boundary condition: true
is: P14060
is encoded by: hsa:3283
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: HSD3B1
is: SBO:0000252
initial concentration: NaN

metaM idp n
is: HMDB03335
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58280
initial amount: NaN
name: IDP(3-)
type: Species

metaR THFtm
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110049#
fast: false
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000

metaR S6T14g
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
modifier: MODEL1310110049#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
fast: false

metaR AG13T1g
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110049#
type: Reaction
reversible: false

metaR AHEXASEly
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110049#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110049#
fast: false

metaR FUMtm
reversible: true
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
fast: false
name: fumarate transport, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
kinetic law: MODEL1310110049#

metaM ksi deg5 l
has only substance units: false
is: HMDB00143
is: CHEBI:12936
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 5

metaR r1527
product: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/4.2.1.1
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_8d6f6097_4596_41ca_871a_f1e6ff0bf34f
type: Species
constant: false
initial amount: NaN
name: LDHB
has only substance units: false
is encoded by: hsa:3945
boundary condition: true
is: P07195
is: SBO:0000252
initial concentration: NaN

metaR AMPtp
is: SBO:0000185
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
kinetic law: MODEL1310110049#
fast: false
name: AMP transporter, peroxisome
type: Reaction

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM 1pyr5c m
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial concentration: 1.0
is: HMDB01301
is: CHEBI:15893
constant: false
boundary condition: false
is: C03912
name: 1-Pyrroline-5-carboxylate
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_62be0c06_d85c_4efc_8042_599953ad0f39
boundary condition: true
type: Species
is encoded by: hsa:54677
constant: false
is: E7EQF2
name: CROT
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR GLCter
type: Reaction
name: glucose transport, endoplasmic reticulum
is: SBO:0000185
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_13b5c3f7_90f0_437f_b5ca_921e2b91b90f
is: SBO:0000252
is: Q6LEN6
name: CHAT
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1103
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_b350a489_5d8b_43c1_8a5a_53aee3231bad
has only substance units: false
is: P19440
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: GGT1
is encoded by: hsa:2678
boundary condition: true
initial amount: NaN

metaM hista c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00870
initial amount: NaN
is: CHEBI:58432
name: histamium
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388

http://identifiers.org/biomodels.db/MODEL1310110049#_42e9349c_3ed7_4a63_abe9_4dcbeeea6717
initial concentration: NaN
initial amount: NaN
is: B7Z763
has only substance units: false
name: AMPD3
is encoded by: hsa:272
is: SBO:0000252
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_ada21ddb_7fa4_404e_b751_47118b07012b
name: NME2
is: P22392
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:4831

metaM retinal cis 13 c
name: 13-cis-retinal
has only substance units: false
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB06220
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_1b4191fe_9ca1_4c73_891a_a20eed8ccd43
constant: false
is encoded by: hsa:204
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: AK2

metaR COAtg
product: MODEL1310110049#
name: CoA transport in Golgi via diffusion
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110049#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_ed1f6b71_7603_4399_9baa_4e4dc4326ee3
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:50700
constant: false
is: Q9NYR8
has only substance units: false
is: SBO:0000252
name: RDH8

metaM hco3 e
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
is: CHEBI:17544
constant: false
is: SBO:0000247
is: C00288
has only substance units: false
initial concentration: 1.0
name: Bicarbonate

http://identifiers.org/biomodels.db/MODEL1310110049#_d5fd15b1_594e_4c3d_b94b_a5892e77b65e
initial amount: NaN
is: Q9NQ66
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PLCB1
is encoded by: hsa:23236
constant: false
type: Species

metaR RE2814M
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
name: RE2814
reversible: true
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_91c5e383_2108_4fde_8489_f34df05175e8
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:1376
has only substance units: false
initial amount: NaN
name: CPT2
is: SBO:0000252
is: P23786

metaR PPDOy
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
product: MODEL1310110049#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is described by: ECO:0000269
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_bb740de4_3d80_4118_8b04_46eb9b88d199
is: Q8WZ48
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: CPT1A
is encoded by: hsa:1374
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaM g2m8mpdol L r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
has only substance units: false
constant: false
is: CHEBI:59093
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM accoa g
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57288
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
constant: false
has only substance units: false

metaM ksi pre10 g
is: CHEBI:58053
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 10
constant: false
boundary condition: false
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00175
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110049#_f71cf87a_b0a2_4d16_a714_ee582a4f04ec
has only substance units: false
constant: false
name: ST8SIA5
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:29906
is: O15466
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:26174
initial amount: NaN
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
type: Species
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_96362388_5c35_4a9c_86e9_04368e94f0d5
boundary condition: true
initial concentration: NaN
is: P05091
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: ALDH2
type: Species
is encoded by: hsa:217

metaR CYTK5n
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
product: MODEL1310110049#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
name: cytidylate kinase (CMP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110049#_3cd76ff5_aaf9_471e_9b8d_a12c50d0746f
initial concentration: NaN
is: Q7LBE3
constant: false
name: SLC26A9
initial amount: NaN
is encoded by: hsa:115019
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM hista e
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00870
initial amount: NaN
is: CHEBI:58432
is: SBO:0000247
name: histamium

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_ddc174db_7295_492a_859c_7aeaa2821b1c
initial amount: NaN
name: ALDH1B1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:219
constant: false
has only substance units: false
type: Species
is: P30837

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_22074611_bbfd_4aaf_9427_261251e561a7
boundary condition: true
has only substance units: false
name: _206_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:206
initial amount: NaN
type: Species
constant: false

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_56085d4d_f318_4bd6_a5ea_7a75c5dc2e50
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10327
type: Species
initial amount: NaN
name: AKR1A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_649191fd_eaab_433d_961b_4a99b5b3f98f
name: VNN3:VNN2:VNN1
initial concentration: NaN
type: Species
is encoded by: hsa:55350
is: SBO:0000297
has part: O95498
initial amount: NaN
is encoded by: hsa:8875
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_3e5d1163_5d60_409c_bd88_c94b5247e870
is: O15305
constant: false
name: PMM2
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:5373
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR RDH1
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
name: retinol dehydrogenase (all-trans)
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_8d47964e_34ca_4a5a_8a8d_bbd307ec246d
constant: false
is encoded by: hsa:30833
name: NT5C
boundary condition: true
has only substance units: false
is: Q8TCD5
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_f4a8306b_f995_4f9d_99b7_3059534310f2
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:145226
type: Species
initial amount: NaN
has only substance units: false
name: RDH12
is: Q96NR8
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_0d87116b_442b_46eb_9522_e510ac15457e
has part: P08195
has only substance units: false
initial concentration: NaN
name: SLC7A10:SLC3A2
boundary condition: true
constant: false
type: Species
is encoded by: hsa:56301
initial amount: NaN
is encoded by: hsa:6520
has part: Q9NS82
is: SBO:0000297

metaM acnamp c
is: CHEBI:27438
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
constant: false
is: SBO:0000247
is: HMDB06268
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: N-Acetylneuraminate 9-phosphate
initial concentration: 1.0

metaR r0002
reactant: MODEL1310110049#
fast: false
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110049#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_dec0254d_eea1_4551_92b6_7ff85c028119
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:6472
initial concentration: NaN
constant: false
has only substance units: false
name: SHMT2
is: B4DJQ3

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110049#
is described by: ECO:0000269
type: Reaction
name: glutamate dehydrogenase (NADP), mitochondrial
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
product: MODEL1310110049#

metaR MMCDm
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
name: Methylmalonyl-CoA decarboxylase, mitochondrial
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/4.1.1.9
reversible: false
type: Reaction

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_33895c9f_967c_46e4_bef8_792eded3defd
has part: P22392
is: SBO:0000297
boundary condition: true
name: NME1:NME2
is encoded by: hsa:4831
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:4830
has part: P15531
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_c07538b2_8f5c_48a1_987c_c3a7c05c4aad
name: HSD17B10
type: Species
is encoded by: hsa:3028
is: Q99714
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM ahcys m
initial amount: NaN
is: CHEBI:16680
constant: false
boundary condition: false
has only substance units: false
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: C00021

metaR RE2814R
name: RE2814
type: Reaction
kinetic law: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_f3190a1a_6a4b_43a9_84d6_2300244a82ba
type: Species
is: SBO:0000297
name: DBT:DLD:BCKDHA:BCKDHB
boundary condition: true
has part: Q9BQL0
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:594

metaR XOLDIOLONEt
is described by: ECO:0000000
fast: false
product: MODEL1310110049#
type: Reaction
name: lipid, flip-flop intracellular transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_abbf9c7a_68b3_4a26_a381_625362da36df
is: O43674
is encoded by: hsa:4711
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: NDUFB5
boundary condition: true

metaR ALADGLNexR
fast: false
is described by: ECO:0000304
reactant: MODEL1310110049#
name: L-alanine/glutamine reversible exchange
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110049#

metaR MCCCrm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.4.1.4
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
is: SBO:0000176
type: Reaction
name: methylcrotonoyl-CoA carboxylase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110049#_7e5fab1e_19b6_4e02_87f3_e812987d1f1b
is: SBO:0000252
type: Species
is: P39656
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:1650
boundary condition: true
name: DDOST
initial concentration: NaN

metaR ITCOAL1m
product: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110049#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110049#
is: SBO:0000176

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01166
is: SBO:0000247
is: CHEBI:57316
boundary condition: false
has only substance units: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_6b1c3f9a_ffa9_45c6_a7fb_b9c9ee81bed8
initial amount: NaN
is: Q9UBM1
is encoded by: hsa:10400
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PEMT
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_923d76c9_4820_4ce9_8999_4913a3e7e5a5
name: MTHFD1
is encoded by: hsa:4522
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: P11586
is: SBO:0000252

metaR r2443
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reactant: MODEL1310110049#
fast: false
reversible: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR G14T16g
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
reactant: MODEL1310110049#
reversible: false

metaM ppi e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Diphosphate
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
is: CHEBI:33019
is: HMDB00250
initial amount: NaN
type: Species

metaM ebastine r
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
name: ebastine
constant: false
is: CHEBI:211060
has only substance units: false
type: Species

metaM idp c
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
is: CHEBI:58280
initial concentration: 1.0
is: HMDB03335
boundary condition: false
has only substance units: false
name: IDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110049#_ab7e7cf9_6d7c_4123_81d0_0d8c95e18c00
initial amount: NaN
is: SBO:0000252
name: GALNT14
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:79623
is: Q96FL9

metaR ACNACNGALGBSIDEte
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
name: acnacngalgbside hs transport
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110049#
is: SBO:0000185
type: Reaction

metaM dnad c
is: SBO:0000247
boundary condition: false
is: HMDB01179
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
type: Species
is: C00857
initial concentration: 1.0
name: Deamino-NAD+
is: CHEBI:18304
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_eef67175_7f21_4abe_aec2_d2c87550104f
type: Species
constant: false
has only substance units: false
name: AMY2B
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:280
is: P19961
is: SBO:0000252
boundary condition: true

metaR PE HStm
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
name: phosphatidylethanolamine scramblase
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM 2mb2coa m
constant: false
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57337
is: SBO:0000247
type: Species
has only substance units: false

metaM accoa c
name: Acetyl-CoA
has only substance units: false
boundary condition: false
type: Species
is: HMDB01206
is: C00024
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_d7d2ccf5_bc4d_4ba6_beea_75e2725908f8
is: P43166
initial concentration: NaN
type: Species
constant: false
name: CA7
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:766
has only substance units: false

metaR DM datp m
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dATP demand
type: Reaction

metaR FACOAL160i
is: SBO:0000176
product: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C160 fatty acid activation
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
reversible: false
fast: false

metaR RE2349C
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is described by: ECO:0000000
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
type: Reaction
kinetic law: MODEL1310110049#
name: RE2349
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_9ac65988_9ec7_4f5b_a0c6_24ecdb359009
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: ST8SIA1
type: Species
is: Q92185
is encoded by: hsa:6489
initial amount: NaN
initial concentration: NaN

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110049#
fast: false
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110049#

metaR HIStN1
product: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Histidine transport (Na, H coupled)
reversible: true
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR COAtm
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000269
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is: SBO:0000185
name: CoA transporter
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_1fc982bd_34b6_42cc_940b_d4fcf1e267c3
has part: P08559
name: DLAT:DLD:PDHA1:PDHB:PDHX
initial concentration: NaN
type: Species
is: SBO:0000297
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5160
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_2363a6af_3498_43a1_adda_961c6637e684
name: GBA
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2629
constant: false
type: Species
is: B7Z6S9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_1debbdba_0d85_4269_ad01_1d982c562cd6
initial amount: NaN
is: SBO:0000252
constant: false
is: P04075
name: ALDOA
initial concentration: NaN
is encoded by: hsa:226
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_325303f9_9fa3_431e_9436_c76baaea8c7e
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q5JT09
has only substance units: false
type: Species
is encoded by: hsa:83549
constant: false
name: UCK1

http://identifiers.org/biomodels.db/MODEL1310110049#_3d66f4d9_07cf_4731_8fbd_4a2edb932506
name: CTH
constant: false
is encoded by: hsa:1491
is: P32929
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR TSTSTERONEtr
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
name: testosterone intracellular transport
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110049#
product: MODEL1310110049#

metaR r0604
modifier: MODEL1310110049#
reversible: false
product: MODEL1310110049#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#

metaM idp e
initial amount: NaN
boundary condition: false
is: HMDB03335
has only substance units: false
name: IDP(3-)
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaM amet c
is: C00019
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
initial amount: NaN
is: HMDB01185
initial concentration: 1.0
is: CHEBI:15414
name: S-Adenosyl-L-methionine

metaR COAtn
kinetic law: MODEL1310110049#
reversible: true
name: coenzyme A transport, nuclear
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9b9ced75_def5_45a5_b81f_c66358835f7f
has only substance units: false
name: NDUFB5
boundary condition: true
constant: false
is: O43674
type: Species
initial concentration: NaN
is encoded by: hsa:4711
is: SBO:0000252
initial amount: NaN

metaM dmnoncoa c
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB11604
name: 4,8 dimethylnonanoyl-CoA
type: Species
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1

metaM 5mthf c
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
is: C00440
boundary condition: false
is: CHEBI:3729
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01396

metaR r0178
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
product: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
type: Reaction

metaR r0714
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
product: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM g6p r
type: Species
is: SBO:0000247
is: CHEBI:61548
initial amount: NaN
has only substance units: false
constant: false
is: C00092
initial concentration: 1.0
boundary condition: false
is: HMDB01401
name: D-Glucose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092

metaR r0156
is: SBO:0000176
fast: false
product: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_443ea2fa_4141_42d4_b36f_c6f67f03b6cc
has only substance units: false
type: Species
is: P54868
name: HMGCS2
constant: false
initial amount: NaN
is encoded by: hsa:3158
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_27488d18_61e8_4799_a23a_9f5d9939c4cd
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:2222
initial amount: NaN
constant: false
name: FDFT1
is: P37268
initial concentration: NaN
boundary condition: true

metaR NDPK10n
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is described by: ECO:0000304
modifier: MODEL1310110049#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR ABO6g
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_57a39c8c_cc99_45eb_ad75_315e82581711
is encoded by: hsa:509
name: ATP5C1
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P36542

metaR COAtp
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
name: coenzyme A transport, peroxisomal

metaR r0179
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_7d6a9b19_b562_4d91_8e69_e7378b20caec
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM HC00718 c
boundary condition: false
type: Species
is: CHEBI:57781
is: SBO:0000247
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_7e236c28_eb03_41e6_8efd_ac6e282c3454
type: Species
has only substance units: false
name: _D29675_1_c
constant: false
is encoded by: hsa:D29675
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM oh1 e
has only substance units: false
constant: false
is: C01328
initial amount: NaN
is: HMDB01039
name: hydroxide ion
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_bf6e5c5e_6c93_47c1_9e02_a2b30e6681dd
name: SLC7A8
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
is: Q9UHI5
is encoded by: hsa:23428

metaR r2334
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_ac219df2_bc19_4997_90bb_5b14e69787a5
name: ND1
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:4535
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: Q85KV6

metaR r0715
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/6.3.2.5
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000000

metaR r0157
product: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/6.3.4.2
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaR NDPK9n
reversible: true
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_b8ca494b_b62e_43b8_a8f7_32a7a9891af5
has only substance units: false
boundary condition: true
name: _NM_013421_1_e
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:NM 013421
type: Species

metaR r1971
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
fast: false
modifier: MODEL1310110049#

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM xoldioloneh c
initial concentration: 1.0
is: CHEBI:2288
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
is: HMDB06887
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
has only substance units: false

metaR r2333
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR S23Tg
is described by: ECO:0000269
product: MODEL1310110049#
fast: false
type: Reaction
modifier: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_f3ce1468_082b_4924_9a2d_4d0ec7209399
type: Species
boundary condition: true
is encoded by: hsa:2348
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: FOLR1
initial amount: NaN

metaM fadh2 c
is: CHEBI:58307
initial amount: NaN
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01197
boundary condition: false
name: FADH2(2-)
has only substance units: false

metaM ppi c
is: HMDB00250
has only substance units: false
initial concentration: 1.0
name: Diphosphate
initial amount: NaN
is: SBO:0000247
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3
constant: false
is: CHEBI:0
type: Species
boundary condition: false

metaM so3 m
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
type: Species
is: CHEBI:17137
boundary condition: false
constant: false
is: HMDB00240
name: hydrogensulfite
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r0009
reversible: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
product: MODEL1310110049#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176
type: Reaction
reactant: MODEL1310110049#

metaM core4 g
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16478
name: Core 4
has only substance units: false
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial concentration: 1.0
boundary condition: false

metaM HC01162 c
initial amount: NaN
type: Species
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: CHEBI:58376
initial concentration: 1.0
constant: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_d182e9fc_c09f_451f_a78b_2bee06b73bfb
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:4718
has only substance units: false
constant: false
name: NDUFC2
initial amount: NaN
is: Q549M5

http://identifiers.org/biomodels.db/MODEL1310110049#_93d7541d_2005_48b9_b9e9_e84041d1d6d0
name: GCK
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P35557
boundary condition: true
is encoded by: hsa:2645
constant: false

metaM 4mzym int2 r
is: SBO:0000247
name: 4-Methylzymosterol intermediate 2
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: HMDB06838
type: Species
has only substance units: false

metaM 5mthf e
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01396
constant: false
is: CHEBI:3729
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
is: C00440

http://identifiers.org/biomodels.db/MODEL1310110049#_45492951_949c_4964_81eb_4e21ac01d80b
has only substance units: false
is: SBO:0000252
name: PCBD1
boundary condition: true
initial concentration: NaN
is: P61457
is encoded by: hsa:5092
constant: false
type: Species
initial amount: NaN

metaR COAtr
kinetic law: MODEL1310110049#
name: COA transporter, endoplasmic reticulum
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaM ahcys r
is: HMDB00939
initial amount: NaN
constant: false
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-adenosyl-L-homocysteine
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR 3HBCOAHLm
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: false
product: MODEL1310110049#
is described by: ECO:0000000
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reactant: MODEL1310110049#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM

metaM fgam c
constant: false
type: Species
is: SBO:0000247
is: HMDB01308
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C04376
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: CHEBI:58426
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide

http://identifiers.org/biomodels.db/MODEL1310110049#_9ef62547_104f_4067_afaa_bbc05fc2f9ee
has only substance units: false
is encoded by: hsa:200010
is: SBO:0000252
initial concentration: NaN
is: E9PAK4
name: SLC5A9
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR r2332
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
reversible: true

metaR GALt4
fast: false
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110049#
name: galactose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_f893c345_e426_4063_922b_54f3e0cbfc9b
has only substance units: false
name: DHCR24
initial concentration: NaN
is encoded by: hsa:1718
boundary condition: true
is: SBO:0000252
constant: false
is: Q15392
initial amount: NaN
type: Species

metaM acgal l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
name: N-acetyl-D-galactosamine
is: HMDB00212
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:28037
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaR r0718
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.181
modifier: MODEL1310110049#
reversible: false
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#

metaR r2113
fast: false
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#

metaM cala c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:11892
boundary condition: false
is: HMDB00026
name: N-carbamoyl-beta-alaninate
constant: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_02da71d6_cc38_4f14_8cc1_f7870b582659
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55967
type: Species
name: NDUFA12
constant: false
is: SBO:0000252
has only substance units: false
is: F8VQS7

http://identifiers.org/biomodels.db/MODEL1310110049#_b3a5038c_df07_4d41_a845_ee947ec54a82
is encoded by: hsa:4706
constant: false
has part: Q16718
is encoded by: hsa:7991
has part: O95139
is encoded by: hsa:126328
is encoded by: hsa:4725
has part: O43678
is encoded by: hsa:4726
has part: Q13454
is encoded by: hsa:4696
has part: O95168
is encoded by: hsa:4723
has part: O95299
has part: P03915
is: SBO:0000297
has part: Q6IBA0
is encoded by: hsa:4695
is encoded by: hsa:4702
is encoded by: hsa:4707
is encoded by: hsa:4717
has part: O43677
has part: Q6IB80
has part: P19404
initial amount: NaN
is encoded by: hsa:4708
has part: P56556
has part: P56181
has part: O00483
is encoded by: hsa:4704
has part: Q6FG42
is encoded by: hsa:4700
is encoded by: hsa:374291
has part: B7Z792
is encoded by: hsa:4698
has part: O00217
has only substance units: false
is encoded by: hsa:51079
has part: Q16795
is encoded by: hsa:4537
has part: Q9Y6M9
has part: A8K761
has part: C9JT23
is encoded by: hsa:4713
is encoded by: hsa:4535
is encoded by: hsa:4697
has part: O43674
has part: B1AM93
is encoded by: hsa:4709
is encoded by: hsa:4719
has part: Q7GXZ1
type: Species
is encoded by: hsa:4705
is encoded by: hsa:4715
is encoded by: hsa:4701
is encoded by: hsa:4711
has part: Q9P0J0
is encoded by: hsa:4718
is encoded by: hsa:4728
has part: Q6IBC4
is encoded by: hsa:4710
is encoded by: hsa:4720
has part: Q7GXZ4
has part: Q85KV6
has part: O95167
initial concentration: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: O75438
is encoded by: hsa:4539
has part: O75489
has part: F8VQS7
is encoded by: hsa:4538
has part: O75251
has part: O14561
has part: Q7GXY9
is encoded by: hsa:4540
has part: P03905
has part: P03897
is encoded by: hsa:55967
boundary condition: true

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM trdox c
is: C00343
type: Species
initial amount: NaN
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
has only substance units: false
is: CHEBI:18191
initial concentration: 1.0
name: Oxidized thioredoxin
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_16acf8cd_89e2_4c52_8c50_57e2272c58b8
constant: false
name: SUCLG1
boundary condition: true
is: P53597
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8802
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: HMDB11123
boundary condition: false
is: SBO:0000247
is: CHEBI:28387
initial concentration: 1.0

metaR r2011
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110049#

metaR r2112
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110049#
fast: false
reversible: true

metaR r2338
reactant: MODEL1310110049#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185

metaR RE1233C
reversible: true
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: RE1233

metaR MALSO3tm
type: Reaction
modifier: MODEL1310110049#
name: Malate:sulfite antiport, mitochondrial
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#
reversible: true
fast: false
is: SBO:0000185

metaR RE3241R
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
name: RE3241
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110049#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_96a3962c_70d6_4325_b2fe_1e925a3ebf18
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: P50443
is encoded by: hsa:1836
has only substance units: false
boundary condition: true
name: SLC26A2

http://identifiers.org/biomodels.db/MODEL1310110049#_c35b9c81_b04c_45be_92f3_1ff3774fc39a
name: AMT
is: P48728
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:275
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM malcoa c
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
type: Species
constant: false
is: CHEBI:57384
name: Malonyl-CoA
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00083
boundary condition: false

metaR UDPDOLPT L
modifier: MODEL1310110049#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.117
fast: false
reversible: false
is: SBO:0000176

metaR r0716
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
is: SBO:0000176

metaR DOPASULT
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
type: Reaction
name: Dopamine Sulfotransferase
reactant: MODEL1310110049#
is: SBO:0000176
reversible: false
modifier: MODEL1310110049#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1

metaR THD1m
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
reversible: true
is version of: http://identifiers.org/ec-code/1.6.1.2
is: SBO:0000185
modifier: MODEL1310110049#
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000269
name: NAD(P) transhydrogenase

metaR r2111
reversible: true
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000185
modifier: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM CE0849 m
initial amount: NaN
constant: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial concentration: 1.0
has only substance units: false
type: Species
name: cis,cis-palmito-7,10-dienoyl-CoA
is: SBO:0000247
boundary condition: false
is: CHEBI:57795

metaR CBASPte
reactant: MODEL1310110049#
reversible: true
name: Transport of N-carbamoyl-L-aspartate
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000134
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM ksi pre4 g
initial amount: NaN
is: C00130
name: keratan sulfate I biosynthesis, precursor 4
has only substance units: false
is: CHEBI:58053
constant: false
boundary condition: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
is: SBO:0000247
is: HMDB00175
initial concentration: 1.0
type: Species

metaM glutcoa m
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57378
name: glutaryl-CoA(5-)
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: SBO:0000247
boundary condition: false
is: HMDB01339

metaR r0717
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM fmn c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: FMN
is: C00061
is: CHEBI:58210
is: HMDB01520

http://identifiers.org/biomodels.db/MODEL1310110049#_f3fab70c_f457_4820_a664_2ff3be3a3134
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q96P26
is encoded by: hsa:93034
boundary condition: true
name: NT5C1B
constant: false

metaM CE2433 m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
is: CHEBI:57795
type: Species

metaR FUT17g
is version of: http://identifiers.org/ec-code/2.4.1.69
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
reversible: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000176

metaM oh1 c
has only substance units: false
type: Species
name: hydroxide ion
constant: false
is: SBO:0000247
is: C01328
initial amount: NaN
is: HMDB01039
boundary condition: false
initial concentration: 1.0
notes: FORMULA: HO CHARGE: -1

metaR DNDPt15m
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110049#
fast: false
is: SBO:0000185
name: dUDP transport via dGDP antiport
modifier: MODEL1310110049#
type: Reaction

metaM hco3 c
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
is: SBO:0000247
is: C00288
boundary condition: false
constant: false
is: HMDB00595
name: Bicarbonate
initial concentration: 1.0
is: CHEBI:17544
has only substance units: false
initial amount: NaN

metaR r2110
product: MODEL1310110049#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110049#
fast: false
is: SBO:0000185
modifier: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110049#

metaR M13N2Tg
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.101
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110049#
type: Reaction

metaM thcholstoic x
type: Species
has only substance units: false
constant: false
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB03873
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaR RE3566C
name: RE3566
reversible: true
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_88c5d98e_19ae_49d8_85ca_3b039b021f03
is encoded by: hsa:54344
is: Q86TM7
name: DPM3
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_82fcdc78_34fc_4a12_83d4_e59bc5ee8bef
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PKM2
is: SBO:0000252
type: Species
is encoded by: hsa:5315
is: P14618
has only substance units: false
constant: false

metaM dha e
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01882
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:16016
name: glycerone
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species

metaR RBFK
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.26
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: riboflavin kinase
kinetic law: MODEL1310110049#
type: Reaction
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000269

metaR GTHRDt
is: SBO:0000185
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reversible: true
name: Glutathione transport into mitochondria
type: Reaction
kinetic law: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ca245849_89a5_4191_b513_78d1a76c3d10
type: Species
constant: false
has only substance units: false
is: O94777
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: DPM2
is encoded by: hsa:8818

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR DADAe
is described by: ECO:0000269
product: MODEL1310110049#
name: Deoxyadenosine deaminase, extracellular
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.4
fast: false
reversible: false
reactant: MODEL1310110049#

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR r2126
product: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_e80abea6_d74a_4879_a77e_f7854d21f6f8
name: ST3GAL3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6487
constant: false
boundary condition: true
is: B4DX62
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_21e3cd55_4585_40dd_8ae1_9fa1f1554370
name: HKDC1
is: B3KT70
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:80201
constant: false
type: Species

metaM cmp g
type: Species
is: CHEBI:60377
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00095
boundary condition: false
name: CMP(2-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaM h2o e
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
constant: false
is: SBO:0000247
initial concentration: 1.0
name: H2O
is: CHEBI:15377

metaR r1979
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reversible: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110049#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110049#

metaM atp e
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: C00002
name: ATP(4-)
is: CHEBI:57299
is: HMDB00538
is: SBO:0000247

metaR CYSASNNaEx
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#

metaR KSItly
reactant: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
fast: false
name: keratan sulfate I transport, extracellular to lysosome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_8c5018be_0d00_4419_9326_c3ce47e31155
is encoded by: hsa:1738
initial concentration: NaN
constant: false
is: P09622
boundary condition: true
initial amount: NaN
type: Species
name: DLD
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_2da68bde_e1dd_4a3d_a5a3_cb70ab0c3881
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PCBD2
is: Q9H0N5
type: Species
is encoded by: hsa:84105
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_2260c08c_fa8e_4a28_ac0e_8aab5a543df7
is encoded by: hsa:9551
is encoded by: hsa:517
type: Species
is: SBO:0000297
initial concentration: NaN
constant: false
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
has only substance units: false
has part: F8W7V3
boundary condition: true

metaR GALASE17ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
kinetic law: MODEL1310110049#

metaR r2127
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
reversible: true
product: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_4b53f4de_077a_4b2f_842e_7c05fcce9dc6
boundary condition: true
is encoded by: hsa:51022
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: GLRX2
has only substance units: false
is: SBO:0000252

metaM thyox L e
is: CHEBI:18332
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
has only substance units: false
is: HMDB00248
name: L-thyroxine

http://identifiers.org/biomodels.db/MODEL1310110049#_e89926a8_3eda_484c_ab8c_01872f20cc84
is: SBO:0000252
is encoded by: hsa:9551
initial amount: NaN
is: Q6IBB3
boundary condition: true
name: ATP5J2
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR MTRI
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110049#
reversible: true
name: 5-methylthioribose-1-phosphate isomerase
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 5.3.1.23 Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
reactant: MODEL1310110049#

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM HC02180 e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28728
type: Species
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
has only substance units: false
boundary condition: false
constant: false
name: thromboxane-b2

http://identifiers.org/biomodels.db/MODEL1310110049#_fa632f0b_2d98_4c46_82df_0818ee7d9ba3
is: Q8IUC8
is: SBO:0000252
name: GALNT13
type: Species
is encoded by: hsa:114805
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaM acnacngalgbside hs g
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: disialyl galactosylgloboside
has only substance units: false
is: C00036
is: HMDB00223
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial amount: NaN

metaM Tn antigen l
is: SBO:0000247
notes: FORMULA: C8H14NO5X CHARGE: 0
initial amount: NaN
has only substance units: false
constant: false
is: C04383
name: Tn antigen
boundary condition: false
initial concentration: 1.0
type: Species

metaM tdcoa x
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: C02593
constant: false
initial amount: NaN
is: CHEBI:57385
boundary condition: false
is: HMDB01521
is: SBO:0000247
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_14fd975a_c645_48f4_b3f1_840cbd6c5206
is encoded by: hsa:123041
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC24A4
type: Species
boundary condition: true

metaM glc D g
is: HMDB00122
has only substance units: false
constant: false
name: D-glucose
type: Species
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
boundary condition: false
is: CHEBI:4167
initial amount: NaN

metaR r2128
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
product: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_e67ba6f0_0bcc_4f2c_a650_8f53658530e1
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
constant: false
is encoded by: hsa:51227
has part: Q92535
type: Species
has part: B3KUV7
is encoded by: hsa:5283
has only substance units: false
has part: Q14442
initial amount: NaN
has part: Q9BRB3
boundary condition: true
has part: O94777
is encoded by: hsa:9091
is: SBO:0000297
is encoded by: hsa:5279
is encoded by: hsa:8818
is encoded by: hsa:5277

metaM h2o g
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02111
name: water
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15377
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR KYNATESYN
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: false
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
is: SBO:0000176
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000000

metaM co2 e
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: C00011
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01967
is: CHEBI:16526
name: CO2

metaM cmp e
type: Species
is: CHEBI:60377
is: SBO:0000247
constant: false
is: HMDB00095
initial amount: NaN
name: CMP(2-)
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0

metaR CYTK14n
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,CTP),nuclear
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false
is described by: ECO:0000269
reversible: true

metaM atp c
constant: false
initial concentration: 1.0
is: CHEBI:30616
name: ATP(4-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00002
type: Species
boundary condition: false
is: HMDB00538

metaR TCYNTt
name: Thiocyanate transport via diffusion (cytosol to extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110049#

metaM andrstrn r
constant: false
type: Species
initial concentration: 1.0
name: androsterone
is: HMDB00031
is: CHEBI:16032
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_01559b5c_ee4f_44e7_9b20_1479d346db80
is: Q9BVK2
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:79053
initial concentration: NaN
name: ALG8
boundary condition: true
has only substance units: false

metaR P4507A1r
is: SBO:0000176
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.14.13.17
is described by: ECO:0000269
modifier: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
kinetic law: MODEL1310110049#
reversible: false
fast: false

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM thyox L c
type: Species
is: CHEBI:18332
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: L-thyroxine
is: SBO:0000247
is: HMDB00248

metaR r2129
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110049#

metaR r0160
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.1.3.2
fast: false
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reactant: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:

metaR r1684
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_6051b9c2_1fc4_40cd_b957_ba0fde2283c6
constant: false
is: SBO:0000252
is encoded by: hsa:81031
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O95528
initial amount: NaN
type: Species
name: SLC2A10

metaM s2l2fn2m2masn e
initial amount: NaN
has only substance units: false
is: C00255
is: CHEBI:3554
boundary condition: false
type: Species
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: SBO:0000247
name: PA6
initial concentration: 1.0
is: HMDB00244
constant: false

metaM 4fumacac c
constant: false
is: CHEBI:18034
has only substance units: false
name: 4-fumarylacetoacetate(2-)
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01268
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061

metaR RDH2a
product: MODEL1310110049#
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: retinol dehydrogenase (9-cis,NADPH)
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.105

http://identifiers.org/biomodels.db/MODEL1310110049#_7514c9e3_0c70_428d_86ba_d0d86387fdba
initial amount: NaN
constant: false
is: SBO:0000252
name: _AI640625_1_c
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI640625

metaM acnacngalgbside hs e
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: disialyl galactosylgloboside
is: C00036
type: Species
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: HMDB00223
boundary condition: false
is: CHEBI:3338

http://identifiers.org/biomodels.db/MODEL1310110049#_f35ca207_5a35_48b9_b068_c8a529964743
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AI440329_1_r
is encoded by: hsa:AI440329
boundary condition: true
type: Species
initial concentration: NaN

metaR r1681
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_7aa2358a_6916_4bd9_a820_c592dc5ca41c
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55753
name: OGDHL
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9ULD0

metaM glc D e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: D-glucose
type: Species
is: CHEBI:4167
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
constant: false

metaR r1540
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
modifier: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_fa355183_e487_4dda_96c8_63c1eb86e387
has only substance units: false
is: Q9NPH0
boundary condition: true
is encoded by: hsa:51205
name: ACP6
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR A4GALTg
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.228
is: SBO:0000176
name: Lactosylceramide 4-alpha-galactosyltransferase
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is described by: ECO:0000269
type: Reaction
product: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#

metaM 3odcoa m
initial amount: NaN
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: SBO:0000247
constant: false
is: HMDB03939
has only substance units: false
is: CHEBI:28528
initial concentration: 1.0
type: Species
boundary condition: false
name: 3-Oxodecanoyl-CoA

metaM s2l2n2m2masn l
constant: false
is: CHEBI:18287
is: SBO:0000247
has only substance units: false
name: de-Fuc form of PA6
type: Species
is: HMDB00174
boundary condition: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
initial concentration: 1.0
initial amount: NaN

metaM tststerone r
is: CHEBI:17347
boundary condition: false
is: HMDB00234
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
has only substance units: false
initial amount: NaN

metaM ebastine e
type: Species
is: SBO:0000247
name: ebastine
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:211060

http://identifiers.org/biomodels.db/MODEL1310110049#_3bb65934_7360_4f46_9e6b_8f6f068baac2
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: CHAT
has only substance units: false
is encoded by: hsa:1103
is: SBO:0000252
is: D3DX95
boundary condition: true

metaR RE1518M
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110049#
type: Reaction
name: RE1518
reversible: true
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_8fe0802b_21a5_4eb3_90d5_dfe5bf338d26
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2876
type: Species
initial amount: NaN
constant: false
name: GPX1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ffed1d81_4640_4fbd_a722_a1bab8d051d7
constant: false
is: P23109
name: AMPD1
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:270
initial concentration: NaN
has only substance units: false

metaR r1260
fast: false
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110049#

metaR r1975
type: Reaction
is: SBO:0000185
reactant: MODEL1310110049#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#

metaR r2341
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaR r1682
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
name: Y+LAT2 Utilized transport

metaM ksii core2 deg2 l
initial amount: NaN
is: HMDB00143
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
initial concentration: 1.0
constant: false
name: keratan sulfate II (core 2-linked), degradation product 2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5f8cd580_71e5_4458_80f1_e14f3d89c2bd
constant: false
type: Species
name: _AI285872_1_c
is encoded by: hsa:AI285872
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_32ef9299_90db_4846_9513_500e62b8aaa9
name: EHHADH
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1962
boundary condition: true
type: Species
is: Q9NY65
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_55268636_85c4_4696_aafa_634ad56945a1
has only substance units: false
name: _H77542_1_r
boundary condition: true
is encoded by: hsa:H77542
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM acnacngalgbside hs c
initial concentration: 1.0
is: C00036
type: Species
boundary condition: false
is: HMDB00223
initial amount: NaN
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
has only substance units: false
constant: false
name: disialyl galactosylgloboside
is: SBO:0000247

metaR LYSOXp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
product: MODEL1310110049#
type: Reaction
reversible: false
reactant: MODEL1310110049#
is: SBO:0000176
name: L-lysine oxidase, peroxisomal
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_7cc4ebc1_5787_425b_b171_1a303777c044
is: P27144
constant: false
initial amount: NaN
is encoded by: hsa:205
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: AK4

http://identifiers.org/biomodels.db/MODEL1310110049#_4a4c9f3c_03f1_4784_bd29_3b676adf0384
is: Q6LEN6
type: Species
boundary condition: true
is encoded by: hsa:1103
initial concentration: NaN
name: CHAT
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaM h2o l
boundary condition: false
is: CHEBI:15377
initial concentration: 1.0
is: SBO:0000247
name: water
type: Species
is: HMDB02111
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaM m5mpdol L r
is: CHEBI:37634
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_3d489bd9_a7e0_4827_8c53_6857136781b2
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: ACY3
is: Q96HD9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:91703

metaM Tn antigen g
name: Tn antigen
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110049#_d3ffb3c8_4594_4c51_8c4d_c6b969fc67f7
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:4830
initial concentration: NaN
name: NME1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_185a32ce_38cb_4866_87f7_2ec58a261d93
initial amount: NaN
name: CPT1B
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1375
is: B7Z5T8
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR LEUPHELAT2tc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM glc D c
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:4167
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
is: HMDB00122
name: D-glucose
initial concentration: 1.0

metaM ebastine c
name: ebastine
type: Species
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:211060

http://identifiers.org/biomodels.db/MODEL1310110049#_4f86a46c_898e_4dc6_84d0_4fb797984363
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: PRPS1L1
type: Species
initial concentration: NaN
is encoded by: hsa:221823

metaR RE0456M
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
name: RE0456
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM amet r
type: Species
is: CHEBI:15414
is: SBO:0000247
initial amount: NaN
is: HMDB01185
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
name: S-adenosyl-L-methionine

metaR ABO4g
kinetic law: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.37
reactant: MODEL1310110049#
product: MODEL1310110049#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
fast: false
modifier: MODEL1310110049#
reversible: false

metaR PI45P5P
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reactant: MODEL1310110049#
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
fast: false
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_171ec41a_7ff1_4c59_aee9_024c16a76f6a
is: O14939
is encoded by: hsa:5338
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: PLD2
boundary condition: true
has only substance units: false

metaR r1262
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_72bdfbac_6f05_4198_a5fd_7288cf243ab7
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q06203
is: SBO:0000252
is encoded by: hsa:5471
type: Species
has only substance units: false
constant: false
name: PPAT

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_c99e9189_1c84_4909_9266_899caef06fe3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11182
type: Species
is: Q9UGQ3
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC2A6

metaR 5ADTSTSTERONESte
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
name: sulfonated testosterone transport
reactant: MODEL1310110049#
product: MODEL1310110049#

metaR r0899
fast: false
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110049#
name: Amino acid transporter ATB0+ Facilitated diffusion
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_71e6006b_9c8c_462b_b7e6_f4268e016adb
is: Q13057
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80347
boundary condition: true
initial concentration: NaN
name: COASY
constant: false
initial amount: NaN

metaR r0186
reversible: false
is described by: ECO:0000000
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
type: Reaction
reactant: MODEL1310110049#

metaR r1680
is: SBO:0000185
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR r1544
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_02e13088_5523_4c53_a7b7_c5c1df320f69
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9BYC5
constant: false
is encoded by: hsa:2530
type: Species
name: FUT8
has only substance units: false

metaM HC00342 c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
name: cis-aconitate(3-)

metaR r0591
type: Reaction
kinetic law: MODEL1310110049#
reversible: true
fast: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9

metaM frdp r
is: C00448
initial amount: NaN
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
initial concentration: 1.0
name: Farnesyl diphosphate
has only substance units: false
type: Species
is: HMDB00961
constant: false
boundary condition: false

metaR CYTDK1
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: ATPcytidine 5-phosphotransferase
kinetic law: MODEL1310110049#
fast: false
reversible: false
modifier: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000254

metaR 3MOX4HOXPGALDOX
is described by: ECO:0000304
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110049#
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_d079481e_7507_4e94_a970_493cc9efdaaf
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2348
is: SBO:0000252
constant: false
type: Species
name: FOLR1
initial amount: NaN
boundary condition: true

metaR F6Tg
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: glycoprotein 6-alpha-L-fucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.68
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
modifier: MODEL1310110049#

metaR ACALDtm
is: SBO:0000185
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
kinetic law: MODEL1310110049#
name: acetaldehyde mitochondrial diffusion
reversible: true
reactant: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_1088f751_6970_4dbe_ae60_849df8a08711
is encoded by: hsa:51251
is: Q9H0P0
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: NT5C3
initial amount: NaN

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaR r0590
modifier: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
fast: false
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_6f4b94de_3ff1_415f_859b_a27841dd0063
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80864
name: EGFL8
is: Q99944
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false

metaM e4p c
is: HMDB01321
has only substance units: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
boundary condition: false
is: CHEBI:16897
name: D-Erythrose 4-phosphate
type: Species
initial amount: NaN
is: C00279
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5913ba66_167f_403d_aaac_261e4bd2f5a3
type: Species
is: Q9NQR4
boundary condition: true
name: NIT2
constant: false
is: SBO:0000252
is encoded by: hsa:56954
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM l2fn2m2masn g
is: CHEBI:28067
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C68H113N4O49X CHARGE: 0
constant: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine

metaR BTNtn
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
name: Biotin transport, nuclear
reversible: true

metaM atp m
is: HMDB00538
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57299
name: ATP(4-)
initial concentration: 1.0
boundary condition: false
is: C00002
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_31734b6d_b54e_4097_a0ea_c1bbff5c4dd3
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: DPYD
initial amount: NaN
is encoded by: hsa:1806
is: Q12882
is: SBO:0000252

metaR PALFATPtc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaM hco3 m
is: HMDB00595
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
constant: false
is: CHEBI:17544
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: Bicarbonate

metaM HC00695 m
name: S-Succinyldihydrolipoamide
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:17432
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: SBO:0000247

metaM 4ppcys c
is: CHEBI:59458
is: C04352
boundary condition: false
type: Species
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial concentration: 1.0
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_2d8be36e_ce5f_4731_8a37_07190d1680ca
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AI620219_1_c
constant: false
type: Species
is encoded by: hsa:AI620219
initial concentration: NaN

metaM amet m
initial concentration: 1.0
constant: false
has only substance units: false
name: S-Adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
is: SBO:0000247
is: HMDB01185
type: Species
is: CHEBI:15414
is: C00019
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_8ce9eb5a_c82d_4c3e_b4ee_67fa36d2afeb
is: SBO:0000252
has only substance units: false
is encoded by: hsa:761
constant: false
name: CA3
is: P07451
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaM HC01180 c
is: SBO:0000247
is: CHEBI:58694
has only substance units: false
name: D-tagatofuranose 1,6-bisphosphate(4-)
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785

http://identifiers.org/biomodels.db/MODEL1310110049#_da427afe_f28c_439f_aac8_1087fb407410
is: O43916
has only substance units: false
is: SBO:0000252
constant: false
name: CHST1
initial concentration: NaN
is encoded by: hsa:8534
initial amount: NaN
boundary condition: true
type: Species

metaR NADtru
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
reversible: false
fast: false
name: NAD transporter, endoplasmic reticulum
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaM arachd x
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:32395
boundary condition: false
name: arachidonate
type: Species
has only substance units: false

metaM acgam6p c
is: CHEBI:57513
is: HMDB01062
name: N-acetyl-D-glucosamine 6-phosphate(2-)
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c7a05204_318f_47d4_855d_1cf8aea214d0
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AI972237_1_c
is encoded by: hsa:AI972237
constant: false
type: Species
has only substance units: false

metaR NACHEX21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM ttdca e
type: Species
name: tetradecanoate (n-C14:0)
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
boundary condition: false
is: SBO:0000247
is: CHEBI:30807
initial concentration: 1.0
is: C06424
has only substance units: false
is: HMDB00806
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_b941ca0a_15f5_4613_8599_01fe4091e41c
constant: false
has only substance units: false
type: Species
is: P15531
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4830
initial amount: NaN
initial concentration: NaN
name: NME1

http://identifiers.org/biomodels.db/MODEL1310110049#_574d2555_8e5a_456d_9694_c39daa99fca6
is: SBO:0000297
type: Species
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
has part: B4DY56
is encoded by: hsa:498

metaM dhbpt c
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
initial concentration: 1.0
is: HMDB00038
type: Species
is: CHEBI:20680
is: SBO:0000247
name: 6,7-dihydrobiopterin

metaR CRNrtx
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
reactant: MODEL1310110049#
name: reversible transport of L-Carnitine in peroxisome
kinetic law: MODEL1310110049#
is described by: ECO:0000134
product: MODEL1310110049#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_c5165183_6153_4afc_bfff_cfe0e570ef83
is: P25705
is encoded by: hsa:498
name: ATP5A1
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_601584a3_00a3_450f_8df1_e7ffe70aea51
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4126
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: MANBA
is: O00462

metaM co2 c
boundary condition: false
initial amount: NaN
name: CO2
is: HMDB01967
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:3313
type: Species
is: C00011
constant: false
has only substance units: false

metaM cmp c
is: CHEBI:60377
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP
has only substance units: false
is: C00055
is: HMDB00095

http://identifiers.org/biomodels.db/MODEL1310110049#_9af799cb_5842_4b57_9bd0_8e98f025107a
initial concentration: NaN
constant: false
is: P21399
is encoded by: hsa:48
has only substance units: false
name: ACO1
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_0d150ad1_61e3_4f67_ae56_3b3ad31895d9
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: DLAT
is: Q86YI5
is encoded by: hsa:1737

metaM ethamp r
constant: false
type: Species
name: O-phosphonatoethanaminium(1-)
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00224
has only substance units: false

metaR r0181
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#

metaM ksii core2 deg1 l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57737
name: keratan sulfate II (core 2-linked), degradation product 1
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
type: Species
boundary condition: false
has only substance units: false
is: HMDB00868

http://identifiers.org/biomodels.db/MODEL1310110049#_5ae0b649_5ee4_486a_93d7_522d785f9983
is encoded by: hsa:1633
is: P27707
name: DCK
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaR r1548
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110049#_64cd6f70_e5c8_4f5c_b2a5_47f06a33b521
initial concentration: NaN
has only substance units: false
type: Species
is: Q9NRA0
boundary condition: true
constant: false
initial amount: NaN
name: SPHK2
is encoded by: hsa:56848
is: SBO:0000252

metaR ASPTA
is: SBO:0000176
name: aspartate transaminase
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:

metaR SCP22x
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.176
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
name: Sterol carrier protein 2
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR DOLMANP Lter
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000185
name: dolichol-phosphate mannose flippase (liver)
reversible: false
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#

metaM gtp c
is: C00044
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:37565
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
name: GTP
type: Species
initial amount: NaN
constant: false

metaR r0594
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
product: MODEL1310110049#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
type: Reaction
fast: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110049#
reactant: MODEL1310110049#

metaR RDH4
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (13-cis,NADH)
modifier: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000269

metaR r0441
reversible: true
type: Reaction
product: MODEL1310110049#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_1ee70736_752d_4cc5_ae49_cbd94e5a0f3c
is: O75387
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC43A1
initial amount: NaN
boundary condition: true
is encoded by: hsa:8501

http://identifiers.org/biomodels.db/MODEL1310110049#_bf5bc115_643d_4bb8_afa9_e3110c37ef89
constant: false
name: SLC35A2
is: P78381
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7355
boundary condition: true
type: Species

metaR GPIDA2er
product: MODEL1310110049#
reactant: MODEL1310110049#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
kinetic law: MODEL1310110049#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_58190759_9219_4882_8b2b_6b1a1503ebed
is: SBO:0000252
is: A0PJJ9
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2686
type: Species
name: GGT7
boundary condition: true
constant: false

metaM atp r
initial concentration: 1.0
type: Species
constant: false
is: HMDB00538
initial amount: NaN
name: ATP(4-)
is: C00002
is: SBO:0000247
boundary condition: false
is: CHEBI:57299
has only substance units: false

metaR r1549
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR AG13T11g
fast: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110049#

metaM pnto R e
has only substance units: false
boundary condition: false
is: CHEBI:7916
is: HMDB00210
name: (R)-Pantothenate
initial concentration: 1.0
constant: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
is: SBO:0000247
type: Species

metaR RDH3
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
product: MODEL1310110049#
fast: false
type: Reaction
reversible: true
name: retinol dehydrogenase (11-cis,NADH)
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176

metaR r1687
reversible: false
reactant: MODEL1310110049#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM h2o c
initial amount: NaN
constant: false
is: CHEBI:3303
notes: FORMULA: H2O CHARGE: 0
type: Species
initial concentration: 1.0
has only substance units: false
name: H2O
is: SBO:0000247
boundary condition: false
is: C00001
is: HMDB02111

metaM dctp n
is: SBO:0000247
is: CHEBI:16311
name: dCTP
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00998
is: C00458

metaR r1546
reversible: true
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#

metaM dmnoncoa x
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA
initial amount: NaN
constant: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
boundary condition: false
is: HMDB11604
type: Species
has only substance units: false
is: SBO:0000247

metaR CRNCARtp
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
name: carnitine-acetylcarnitine carrier, peroxisomal
reactant: MODEL1310110049#
type: Reaction

metaM atp n
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
boundary condition: false
is: CHEBI:57299
name: ATP(3-)
type: Species
is: HMDB00538
initial amount: NaN
has only substance units: false
constant: false

metaM ksi deg12 l
boundary condition: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
initial concentration: 1.0
has only substance units: false
is: CHEBI:12936
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 12
type: Species

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR r0443
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110049#
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110049#
type: Reaction

metaR RE2998M
modifier: MODEL1310110049#
name: RE2998
is described by: ECO:0000000
product: MODEL1310110049#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR r0596
product: MODEL1310110049#
type: Reaction
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
is described by: ECO:0000000

metaR RDH2
reactant: MODEL1310110049#
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
reversible: true
name: retinol dehydrogenase (9-cis,NADH)

metaR PI45PLC
reactant: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110049#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is: SBO:0000176
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD

metaM xol25oh r
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:42977
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
initial amount: NaN
is: HMDB06247
name: 25-hydroxycholesterol
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_1f6f615e_36b6_4fd4_8afb_3c859d23f121
is encoded by: hsa:4846
is: A0S0A7
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: NOS3
type: Species

metaR PSDm hs
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
name: Phosphatidylserine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.65
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_912eef88_2ffa_4243_b50e_b7fe4a8ff8ec
type: Species
constant: false
is encoded by: hsa:51292
is: SBO:0000252
initial concentration: NaN
name: GMPR2
initial amount: NaN
boundary condition: true
has only substance units: false

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_47bc2c79_7a42_4a21_9c8b_5a9b092e8815
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC33A1
is encoded by: hsa:9197
type: Species
is: O00400
constant: false
initial amount: NaN
initial concentration: NaN

metaR r1547
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110049#
fast: false
reversible: true
is: SBO:0000185

metaM pnto R c
type: Species
boundary condition: false
name: (R)-Pantothenate
initial concentration: 1.0
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
is: HMDB00210
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM tdcoa m
is: C02593
constant: false
is: HMDB01521
has only substance units: false
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57385

http://identifiers.org/biomodels.db/MODEL1310110049#_9b9d7fc6_c66a_4104_b020_c5aa5ecf0b8e
constant: false
is: SBO:0000297
type: Species
is encoded by: hsa:8818
has part: P37287
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5277
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN

metaR S6T15g
product: MODEL1310110049#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110049#

metaR DOLASNT Ler
is described by: ECO:0000000
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
is: SBO:0000176
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.119
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
fast: false
reversible: false

metaR PROSTGI2t
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
reactant: MODEL1310110049#
name: Prostaglandin I2 transport
is described by: ECO:0000269
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true

metaR r1824
modifier: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#
is: SBO:0000185

metaR ABTti
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
reversible: false
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
name: L-arabinitol transport via passive diffusion

metaR HISSNAT5tc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_128e18d1_aab0_4ebb_951a_1fb9defdb9fe
is encoded by: hsa:AA526438
has only substance units: false
name: _AA526438_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR XYLt
is described by: ECO:0000269
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
name: D-xylose reversible transport
fast: false
product: MODEL1310110049#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_05cd0af3_8ebf_4ee4_b638_e9f10e9240cd
boundary condition: true
is: P39877
name: PLA2G5
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:5322
is: SBO:0000252

metaR N2M2NMASNt
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110049#
name: n2m2nmasn transport, Golgi to extracellular
fast: false
product: MODEL1310110049#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_a95e20f4_168a_4cb4_b97a_06c1ddbc1ef4
constant: false
type: Species
is encoded by: hsa:2182
has only substance units: false
initial concentration: NaN
is: O60488
boundary condition: true
is: SBO:0000252
name: ACSL4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_68c6f36b_7f9b_4747_bb39_81190329234b
type: Species
constant: false
name: ATP5I
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:521
initial amount: NaN
is: P56385
has only substance units: false

metaR r0013
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_8ce67a02_51da_4cd8_b862_7d9dcde331f6
name: _22305_2_c
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:22305
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d098f659_a136_4f74_98ac_0d8d744002c2
is encoded by: hsa:6487
initial amount: NaN
has only substance units: false
constant: false
name: ST3GAL3
boundary condition: true
initial concentration: NaN
is: Q5T4Y1
is: SBO:0000252
type: Species

metaM tststerone e
has only substance units: false
type: Species
is: HMDB00234
initial amount: NaN
name: testosterone
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17347
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c6c6d3d1_80c6_41f3_982a_9c77d2a3d0c2
name: HPGDS
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:27306
initial concentration: NaN
is: O60760
initial amount: NaN
has only substance units: false

metaM gdp g
name: GDP(3-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: CHEBI:58189
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_96a2f31a_2f58_46a9_bbb9_fb799c5adfad
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AL048840
name: _AL048840_1_c
constant: false
boundary condition: true
initial amount: NaN

metaR O2ter
kinetic law: MODEL1310110049#
name: O2 transport, endoplasmic reticulum
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000

metaR ACCOAgt
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110049#
name: acetyl-coa transport
reactant: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
fast: false
type: Reaction
reversible: true

metaM co2 x
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16526
type: Species
constant: false
is: SBO:0000247
name: carbon dioxide
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
is: HMDB01967

metaR HACD9m
is described by: ECO:0000134
modifier: MODEL1310110049#
type: Reaction
reversible: true
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_4def0bb1_07da_4135_8be0_b2e004f39755
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: IDI2
is: Q9BXS1
boundary condition: true
is encoded by: hsa:91734

metaM hpyr c
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01352
name: 3-hydroxypyruvate
is: SBO:0000247
is: CHEBI:17180
constant: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_6646434c_e5c1_4a71_809a_37df08d6ba11
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6487
is: SBO:0000252
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110049#_c09b6b72_3871_4405_941c_7ca6c5052aac
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4199
is: P48163
type: Species
name: ME1
initial amount: NaN
has only substance units: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110049#_bdee68fa_4aca_4db7_8fd5_44e8e9788edd
is: B2RAU6
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PIGQ
type: Species
is encoded by: hsa:9091
has only substance units: false
constant: false
initial concentration: NaN

metaM cgly c
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
boundary condition: false
name: L-cysteinylglycine
constant: false
is: CHEBI:4047
is: HMDB00078
initial concentration: 1.0

metaM btn n
constant: false
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: biotinate
is: CHEBI:57586
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_b58d5e1f_4ea4_4697_a13a_81e0825b4bb5
initial concentration: NaN
name: SLC5A6
has only substance units: false
initial amount: NaN
is: Q9HD19
is encoded by: hsa:8884
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaM HC02214 e
is: CHEBI:28852
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: prostaglandin-f1alpha
type: Species
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1

metaM ethamp c
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB00224
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: ethamp[c]
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190

http://identifiers.org/biomodels.db/MODEL1310110049#_edaf1dfa_4401_471c_a01a_a5cac07f6805
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2592
name: GALT
type: Species
is: B2RAT6
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_1a255618_c041_4a2b_a136_e13434dee1e4
boundary condition: true
is encoded by: hsa:AW277253
name: _AW277253_1_c
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM hyptaur c
is: HMDB00965
has only substance units: false
is: CHEBI:16668
name: Hypotaurine
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
constant: false
initial concentration: 1.0
initial amount: NaN

metaM mi1345p c
initial amount: NaN
is: SBO:0000247
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57895
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
type: Species
is: HMDB01059
constant: false
has only substance units: false

metaR r1538
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
product: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
modifier: MODEL1310110049#
reversible: false
type: Reaction

metaM h2o x
is: CHEBI:15377
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
is: SBO:0000247
constant: false
is: C00001
name: H2O
initial amount: NaN
is: HMDB02111
type: Species
boundary condition: false

metaM gal1p c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
is: CHEBI:58336
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: HMDB00645
type: Species
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate

http://identifiers.org/biomodels.db/MODEL1310110049#_8e688ae1_d68f_4941_b21a_f9fc41a06436
initial concentration: NaN
name: NDUFS4
is: SBO:0000252
boundary condition: true
has only substance units: false
is: O43181
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4724

metaM btn m
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: biotinate
is: CHEBI:57586
has only substance units: false
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120

metaM prpp e
is: HMDB00280
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0
boundary condition: false
is: CHEBI:58017
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

metaR Uritn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000000
name: uridine transport in nucleus
product: MODEL1310110049#

metaR GLUDxm
name: glutamate dehydrogenase (NAD) (mitochondrial)
reversible: true
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
product: MODEL1310110049#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110049#

metaR r0437
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_10e3ff7f_c9a7_426d_9188_e0cb7da28514
is: Q8WWX8
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:115584
name: SLC5A11
is: SBO:0000252
constant: false
has only substance units: false

metaR ADK1
kinetic law: MODEL1310110049#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false

metaM HC02214 c
type: Species
constant: false
is: CHEBI:28852
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
initial concentration: 1.0

metaM cgly e
is: CHEBI:4047
initial concentration: 1.0
name: L-cysteinylglycine
is: HMDB00078
type: Species
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false

metaR NRPPHRSULT
type: Reaction
product: MODEL1310110049#
name: Norepinephrine Sulfotransferase
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

http://identifiers.org/biomodels.db/MODEL1310110049#_67a8c129_5ce0_4b41_a73c_66d9dfb4715d
constant: false
name: SQLE
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6713
has only substance units: false
initial amount: NaN
is: Q5HYI4
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_3e03e33e_813f_4a47_bbe5_42cf64df7372
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: PDHA2
type: Species
is encoded by: hsa:5161
boundary condition: true
is: P29803
is: SBO:0000252

metaM pro L e
name: L-proline
boundary condition: false
initial amount: NaN
is: CHEBI:17203
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162

http://identifiers.org/biomodels.db/MODEL1310110049#_aee2e7d8_bb29_4aba_bdda_ae3e25584a74
has part: P57054
is encoded by: hsa:9091
has only substance units: false
constant: false
type: Species
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:5277
boundary condition: true
is encoded by: hsa:51227
is encoded by: hsa:5279
has part: B2RAU6
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_a662c45b_fbb0_4f7a_bad7_3a852ef3cfe4
is: P40394
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:131
name: ADH7
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_e739313a_fce7_4248_97dd_f44b2cd7bde1
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GALNTL2
initial amount: NaN
has only substance units: false
is: Q8N3T1
is encoded by: hsa:117248
constant: false

metaR FUCtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: false
fast: false
kinetic law: MODEL1310110049#
name: L-fucose efflux from lysosome
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM Asn X Ser Thr l
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:28938
name: protein-linked asparagine residue (N-glycosylation site)
is: HMDB00051
boundary condition: false
is: C01342
initial amount: NaN
constant: false

metaR Uritm
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
name: uridine facilated transport in mitochondria
reversible: true
modifier: MODEL1310110049#

metaR RPEc
product: MODEL1310110049#
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
name: ribulose 5-phosphate 3-epimerase
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110049#_87a1312c_3773_478d_9ca1_b9227f1abfc8
constant: false
type: Species
boundary condition: true
name: _AI373818_1_m
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI373818
is: SBO:0000252

metaR VLCSp
product: MODEL1310110049#
is described by: ECO:0000269
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110049#
reversible: false
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR DPMVDc
name: diphosphomevalonate decarboxylase, cytosol
reversible: false
is described by: ECO:0000134
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.1.1.33
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_3a5ddf25_3d8f_4db8_aae3_1a0c2a4a580b
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:112724
name: RDH13
constant: false
is: B3KVA3
boundary condition: true
is: SBO:0000252

metaM prpp c
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial amount: NaN
is: HMDB00280
is: CHEBI:58017
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
has only substance units: false
initial concentration: 1.0

metaM cholp c
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
type: Species
is: SBO:0000247
name: choline phosphate(1-)
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:295975
has only substance units: false

metaR FE2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
type: Reaction
reactant: MODEL1310110049#
reversible: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
name: iron (II) transport
is: SBO:0000185

metaM arachd r
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: arachidonate
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
type: Species
is: CHEBI:32395

metaR G14T15g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110049#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110049#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110049#_cdab2c3c_c731_4e6c_95ee_d56b4c9174f2
is encoded by: hsa:2645
has only substance units: false
initial amount: NaN
name: GCK
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR KCC2t
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
product: MODEL1310110049#
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false

metaR DOLPMT4 Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110049#
reversible: false
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110049#

metaR DM anth
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM galgluside hs l
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
name: galactosyl glucosyl ceramide
has only substance units: false
is: HMDB00143

metaR GLNtN1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
is: SBO:0000185
fast: false
name: Glutamine transport (Na, H coupled)
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#

metaM tststerone c
is: HMDB00234
constant: false
boundary condition: false
name: testosterone
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
type: Species
is: SBO:0000247
is: CHEBI:17347
has only substance units: false

metaR UPPN
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
reversible: false
name: b-ureidopropionase
is: SBO:0000176
is described by: ECO:0000269
fast: false
product: MODEL1310110049#
modifier: MODEL1310110049#

metaR TAUBETAtc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaR ADK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is described by: ECO:0000269
type: Reaction
name: adentylate kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
modifier: MODEL1310110049#

metaM atp x
has only substance units: false
name: ATP(4-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:57299
is: C00002
is: HMDB00538

metaR r1117
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
name: Facilitated diffusion
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:

metaR DOLPMT U
reversible: false
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.83
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
product: MODEL1310110049#
fast: false

metaM HC00342 m
initial amount: NaN
is: SBO:0000247
name: cis-aconitate(3-)
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16383
has only substance units: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417

metaM CE2434 m
initial concentration: 1.0
is: CHEBI:57795
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
boundary condition: false
type: Species
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial amount: NaN

metaM o2s x
is: SBO:0000247
is: HMDB02168
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: superoxide
is: CHEBI:18421
initial amount: NaN
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species

metaM 3mob m
name: 3-methyl-2-oxobutanoate
is: HMDB00019
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:11851
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species

metaM tdcoa c
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57385
has only substance units: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
is: SBO:0000247
is: C02593

metaR r1116
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
reversible: true

metaM aps c
name: 5'-adenylyl sulfate(2-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:58243
is: HMDB01003
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5fb8d945_5600_4796_9623_936d7ae843c7
is: Q06278
boundary condition: true
has only substance units: false
is encoded by: hsa:316
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: AOX1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_439288ed_7cfa_4219_b79d_22cd0ea83358
name: BCKDHB
is: P21953
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:594

metaM arachd e
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01043
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
initial concentration: 1.0
type: Species
is: CHEBI:32395
is: SBO:0000247

metaR GMAND
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
product: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
name: GDP-D-mannose dehydratase
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.47

metaM HC02187 e
is: CHEBI:28774
name: reverse-triiodthyronine
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaR LEUt5m
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
fast: false
reversible: true
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM

metaM h2o m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: C00001
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
is: HMDB02111
is: CHEBI:15377
name: H2O
constant: false

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR ARGtm
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000269
fast: false
type: Reaction
name: arginine mitochondrial transport via ornithine carrier
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
is: SBO:0000185

metaM frdp c
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
is: SBO:0000247
name: Farnesyl diphosphate
has only substance units: false
boundary condition: false
is: CHEBI:175763
type: Species
is: C00448

metaR GALt1r
product: MODEL1310110049#
name: galactose transport (uniport)
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_211798fd_6150_47c8_b463_495202fc4dbb
has only substance units: false
type: Species
is: SBO:0000252
name: GCDH
boundary condition: true
initial amount: NaN
is encoded by: hsa:2639
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_85e31bfe_dad0_442d_891a_6c7a2dda8fa7
is: O75489
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4722
name: NDUFS3

metaM btn c
is: CHEBI:3420
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: Biotin
initial amount: NaN
has only substance units: false

metaR GLYCtm
reversible: true
reactant: MODEL1310110049#
name: glycerol transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
fast: false

metaR r2344
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110049#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
reversible: true

metaR DIDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
name: dIDP nuclear transport
fast: false
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_a96b35b0_dc9c_41c5_8fce_3963f91d01c1
is encoded by: hsa:8776
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: Q13613
initial amount: NaN
is: SBO:0000252
name: MTMR1
has only substance units: false

metaR ACACT7p
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110049#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is described by: ECO:0000269
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_fucgalacgalfuc12gal14acglcgalgluside_hs_g
is: HMDB00304
boundary condition: false
constant: false
name: Type IIIH glycolipid
notes: FORMULA: C70H122N3O40FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: CHEBI:57847
is: SBO:0000247
initial amount: NaN
type: Species

metaR GLNtm
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
reversible: false
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)

metaM h2o n
name: water
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB02111
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110049#_a462a30a_bd10_4c28_b25d_966ef583a11e
initial amount: NaN
name: _BG035985_1_c
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:BG035985

metaR PCHOLP hs
is: SBO:0000176
name: choline phosphatase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
reactant: MODEL1310110049#
reversible: false
type: Reaction
product: MODEL1310110049#

metaM glc D r
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:4167
name: D-glucose
initial amount: NaN
constant: false
is: HMDB00122
is: SBO:0000247

metaR GTHPm
product: MODEL1310110049#
name: glutathione peroxidase, mitochondria
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.15
reversible: true
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
fast: false
is described by: ECO:0000269
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12

http://identifiers.org/biomodels.db/MODEL1310110049#_dab8eec0_bba7_423d_8c25_847a62d53647
name: ND5
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4540
is: SBO:0000252
is: P03915

metaR r2347
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
reversible: true
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_eee59621_c592_4f5b_bbb0_8dc65e534175
initial concentration: NaN
name: _AI378339_1_m
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AI378339
boundary condition: true
type: Species
has only substance units: false

metaR FBP
is version of: http://identifiers.org/ec-code/3.1.3.11
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
name: fructose-bisphosphatase
modifier: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
reversible: false

metaM gdp n
initial concentration: 1.0
boundary condition: false
name: GDP(3-)
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
constant: false
type: Species
is: CHEBI:58189
is: SBO:0000247
is: HMDB01201

metaR r2121
fast: false
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_7b2c3d24_f042_4425_8570_c5c2b51df835
initial concentration: NaN
is: Q546Y9
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57379
name: AICDA
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_14fe7c86_b79b_4e93_b484_b8a89db16da3
initial concentration: NaN
is: Q8NCL4
constant: false
has only substance units: false
type: Species
boundary condition: true
name: GALNT6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11226

metaM 3hpp m
boundary condition: false
constant: false
is: CHEBI:16510
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: SBO:0000247
has only substance units: false
name: 3-hydroxypropionate
type: Species
is: HMDB00700
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_33f189dd_7f0e_4825_966e_c1f350bdcc2f
is encoded by: hsa:AL038231
name: _AL038231_1_c
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM co2 m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01967
is: C00011
name: CO2
has only substance units: false

metaM pro L c
initial concentration: 1.0
name: L-proline
has only substance units: false
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
is: CHEBI:17203
is: HMDB00162
initial amount: NaN
type: Species
boundary condition: false

metaM dctp c
name: dCTP
is: C00458
constant: false
is: CHEBI:16311
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
is: HMDB00998

metaR r2346
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_2427e186_6712_493d_b184_bc6557639323
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: _U37519_1_c
is encoded by: hsa:U37519
boundary condition: true
initial concentration: NaN

metaM btn e
has only substance units: false
is: HMDB00030
is: SBO:0000247
is: C00120
notes: FORMULA: C10H15N2O3S CHARGE: -1
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Biotin
is: CHEBI:3420

metaR FUT16g
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: Galactoside 2-alpha-L-fucosyltransferase 1
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
fast: false
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false

metaR r2120
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: true
fast: false
modifier: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110049#

metaM gdp m
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
is: HMDB01201
initial amount: NaN
has only substance units: false
name: GDP
constant: false
initial concentration: 1.0
boundary condition: false
is: C00035
type: Species

metaM Asn X Ser Thr r
type: Species
is: SBO:0000247
initial amount: NaN
is: C01342
initial concentration: 1.0
constant: false
notes: FORMULA: XH CHARGE: 0
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
has only substance units: false
is: CHEBI:28938
is: HMDB00051

http://identifiers.org/biomodels.db/MODEL1310110049#_048752a0_2a8f_4926_bfde_b3ba168a65eb
is: B2RD24
boundary condition: true
is encoded by: hsa:25902
type: Species
constant: false
initial amount: NaN
name: MTHFD1L
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM cmp n
is: SBO:0000247
is: HMDB00095
has only substance units: false
boundary condition: false
name: CMP(2-)
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
initial concentration: 1.0

metaM glcur c
boundary condition: false
has only substance units: false
is: CHEBI:15748
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
is: HMDB00127
name: D-glucuronate
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_11750628_0e9c_44b1_b2d2_e218b7dd5d44
initial concentration: NaN
is encoded by: hsa:AI601100
boundary condition: true
name: _AI601100_1_m
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaM orot e
initial concentration: 1.0
is: SBO:0000247
name: orotate
boundary condition: false
is: HMDB00226
initial amount: NaN
is: CHEBI:30839
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
has only substance units: false
type: Species

metaM 4ppcys m
initial concentration: 1.0
is: CHEBI:59458
initial amount: NaN
is: HMDB01117
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false

metaR ASAH1
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.23
fast: false
modifier: MODEL1310110049#
is: SBO:0000176
name: N-acylsphingosine amidohydrolase
reversible: false
product: MODEL1310110049#

metaR r2123
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
fast: false
type: Reaction
modifier: MODEL1310110049#
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_366145cf_8727_44c3_830c_d6b13bfcc814
constant: false
is: SBO:0000252
is encoded by: hsa:57818
has only substance units: false
initial concentration: NaN
is: E9PAX2
boundary condition: true
type: Species
name: G6PC2
initial amount: NaN

metaR DOPAt4 2 r
is described by: ECO:0000269
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110049#
reversible: true
fast: false
modifier: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
name: Dopamine reversible transport in via sodium symport (1:2)
type: Reaction

metaM c14dccoa x
has only substance units: false
type: Species
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: tetradecanedioylcoa
constant: false
is: HMDB00705
initial amount: NaN

metaR r2122
product: MODEL1310110049#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_13b690ed_8014_41f7_b861_86ad8559ff72
is: Q96L53
type: Species
boundary condition: true
is: SBO:0000252
name: ST3GAL3
is encoded by: hsa:6487
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR GLCAASE5ly
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
name: beta-glucuronidase, lysosomal
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110049#_235edb02_133b_4aed_8084_05b979d5118d
is: SBO:0000252
initial amount: NaN
constant: false
name: GBA
is: B7Z6S1
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:2629
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_0f5a1b97_a0a2_4d8b_9247_9d9267c44ea8
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: ATP5G3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:518
initial amount: NaN

metaM h2o r
has only substance units: false
type: Species
is: CHEBI:15377
boundary condition: false
is: HMDB02111
is: C00001
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
initial concentration: 1.0
constant: false
name: H2O

metaM o2s n
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
is: HMDB02168
boundary condition: false
name: superoxide
is: CHEBI:18421
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_e93eca73_00f6_443f_ae07_6c106f4899cf
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: ADH5
initial concentration: NaN
is: Q6IRT1
is encoded by: hsa:128
type: Species
constant: false

metaM s2l2n2m2masn e
notes: FORMULA: C84H135N6O61X CHARGE: -2
type: Species
has only substance units: false
name: de-Fuc form of PA6
is: CHEBI:3554
is: SBO:0000247
is: C00255
boundary condition: false
is: HMDB00244
constant: false
initial concentration: 1.0
initial amount: NaN

metaM glcur e
has only substance units: false
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
constant: false
is: CHEBI:15748
is: HMDB00127
initial concentration: 1.0
name: D-glucuronate
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_abc55377_50d2_40a6_a33a_f0ea3111f1f8
name: _BF195998_1_x
has only substance units: false
is encoded by: hsa:BF195998
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR XYLtly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
name: Xylose efflux from lysosome
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_3cd74c4a_2216_4dec_8490_129550a47b53
name: NDUFV2
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P19404
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:4729
initial concentration: NaN

metaR SERPT
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.50
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110049#
name: serine C-palmitoyltransferase
kinetic law: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#

metaR CYTK6n
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110049#
name: cytidylate kinase (CMP,CTP),nuclear
type: Reaction
reversible: true
product: MODEL1310110049#

metaM orot c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: C00295
has only substance units: false
name: Orotate
is: HMDB00226
initial amount: NaN
is: CHEBI:30839
constant: false
type: Species
initial concentration: 1.0

MODEL1310110049
species: metaM 2oxoadp m
reaction: metaR PUNP2
species: metaM ksi deg12 l
reaction: metaR DUTPDPn
species: metaM csn e
reaction: metaR GCC2am
species: metaM HC01104 e
reaction: metaR r2389
reaction: metaR ACACtx
species: metaM aps c
species: metaM sphgn c
reaction: metaR r0997
reaction: metaR DTDPtn
species: metaM prostgi2 e
reaction: metaR LEUGLYHYc
species: metaM btn m
reaction: metaR NRPPHRt4 2 r
reaction: metaR DHCRD1
species: metaM 10fthf5glu e
species: metaM glcur e
reaction: metaR r0885
reaction: metaR r1613
reaction: metaR EX ebastine LPAREN e RPAREN
reaction: metaR RDH1
species: metaM icit m
reaction: metaR FAOXC12DCTc
reaction: metaR NACASPAH
reaction: metaR ETOHt
reaction: metaR GALASE16ly
reaction: metaR r0670
reaction: metaR TAURtcx
reaction: metaR r0400
reaction: metaR MDHx
reaction: metaR NDPK6
species: metaM ade e
reaction: metaR r2104
reaction: metaR ADEt
reaction: metaR 5MTHFt2le
species: metaM nadph c
reaction: metaR RE1534M
reaction: metaR EX ins LPAREN e RPAREN
species: metaM amp x
reaction: metaR ACOAD1fm
reaction: metaR r0426
species: metaM HC02020 r
reaction: metaR r0022
species: metaM chito2pdol L c
species: metaM clpnd e
species: metaM pail5p hs n
reaction: metaR EX asn L LPAREN e RPAREN
species: metaM dgmp e
species: metaM m5mpdol L r
reaction: metaR r1551
reaction: metaR ACGAM6PSi
species: metaM ctp n
reaction: metaR 4MOPt2im
reaction: metaR r1547
reaction: metaR r1606
reaction: metaR r0817
reaction: metaR r1643
reaction: metaR r0193
reaction: metaR NDPK1n
species: metaM gbside hs l
species: metaM citr L e
reaction: metaR GALNTg
species: metaM itp c
reaction: metaR r0086
species: metaM co2 e
species: metaM cmp e
species: metaM ivcoa m
reaction: metaR G12MT1 L
reaction: metaR 2DR1PP
species: metaM core3 g
reaction: metaR FACOAL140i
species: metaM gsn c
species: metaM cgly c
reaction: metaR r0531
species: metaM 3hmbcoa m
species: metaM c226coa x
species: metaM 3m4hpga c

metaM HC02187 c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:28774
name: reverse-triiodthyronine
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR GLCSGLT1le
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaM 3mob c
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
constant: false
type: Species
is: HMDB00019
initial concentration: 1.0
boundary condition: false
is: CHEBI:11851
is: SBO:0000247
has only substance units: false
name: 3-methyl-2-oxobutanoate

metaR r2125
modifier: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110049#

metaR DOLPMT L
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
reversible: false
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.83
name: Dolichyl-phosphate D-mannosyltransferase (liver)
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction

metaR r0706
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
kinetic law: MODEL1310110049#
is: SBO:0000176
type: Reaction
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
fast: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.10
is described by: ECO:0000000
reversible: false
product: MODEL1310110049#

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM gluside hs c
is: CHEBI:18368
boundary condition: false
has only substance units: false
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
constant: false
is: SBO:0000247

metaR KCCt
reactant: MODEL1310110049#
type: Reaction
reversible: true
kinetic law: MODEL1310110049#
name: K+-Cl- cotransport
fast: false
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
modifier: MODEL1310110049#

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR r2124
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110049#
fast: false
reversible: true

metaR r0707
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
is described by: ECO:0000000

metaM co2 r
is: HMDB01967
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16526
type: Species
is: C00011
constant: false
name: CO2
has only substance units: false

metaM glc D l
is: HMDB00122
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
is: SBO:0000247
name: D-glucose
constant: false
initial amount: NaN

metaM gacpail hs c
is: CHEBI:61548
is: HMDB01401
has only substance units: false
is: C00092
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_b6678d8c_16d7_4332_9fe3_4f8b3f4df48a
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8560
name: DEGS1

metaM 3mob e
initial amount: NaN
boundary condition: false
type: Species
name: 3-methyl-2-oxobutanoate
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: CHEBI:11851
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaR RE3565C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
name: RE3565
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9d09f10b_cfd9_4a22_b293_e86de750c084
type: Species
initial amount: NaN
is encoded by: hsa:4731
initial concentration: NaN
name: NDUFV3
is: P56181
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaR NDP7er
type: Reaction
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110049#

metaR r0472
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_8f17739f_6545_4dad_89a8_be5575b0dc4f
is encoded by: hsa:66002
initial amount: NaN
is: SBO:0000252
name: CYP4F12
constant: false
boundary condition: true
is: Q9HCS2
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_64c92655_340f_4c1a_8aec_79db45aef61e
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: ATP5G2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:517
type: Species

metaM dad 2 c
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00101
constant: false
name: 2-deoxyadenosine
initial amount: NaN
is: CHEBI:17256
boundary condition: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431

metaR PUNP3
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Guanosine)
reversible: true
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_f341b121_7f09_4218_9afd_ce98c2424100
has only substance units: false
initial concentration: NaN
name: SLC13A5
type: Species
constant: false
is encoded by: hsa:284111
initial amount: NaN
boundary condition: true
is: Q86YT5
is: SBO:0000252

metaR RE1898C
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
name: RE1898
fast: false
type: Reaction
kinetic law: MODEL1310110049#

metaR G6Pter
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
kinetic law: MODEL1310110049#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is: SBO:0000185
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000269
reversible: true

metaM c226coa c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: C16169
is: SBO:0000247
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
name: cervonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110049#_adcd322a_bcfb_4359_a182_6f2f39826c09
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9BRB3
name: PIGQ
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9091

metaM cholate e
is: CHEBI:29747
name: Cholate
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00619
initial amount: NaN
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695

metaR GGH 5DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
name: Gamma-glutamyl hydrolase (5DHF), extracellular
modifier: MODEL1310110049#
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_f661612a_043f_4149_8d55_43b6c838217a
boundary condition: true
is encoded by: hsa:4536
is: SBO:0000252
name: ND2
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: Q7GXY9

metaM gal c
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00143
is: SBO:0000247
is: CHEBI:0
constant: false
has only substance units: false
name: D-Galactose
is: C00124
type: Species

metaR FACOAL140i
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110049#
is: SBO:0000176
name: fatty-acid--CoA ligase (tetradecanoate)
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
reversible: false
reactant: MODEL1310110049#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110049#

metaR PUNP4
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110049#_100bed99_f59f_41ae_807a_fe59830727aa
is: SBO:0000252
is: Q71UM8
name: ADCY2
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:108

metaM ppa m
is: SBO:0000247
is: HMDB00237
name: propionate
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:17272
boundary condition: false

metaM dpcoa c
initial amount: NaN
type: Species
is: CHEBI:57328
is: HMDB01373
boundary condition: false
has only substance units: false
name: Dephospho-CoA
is: SBO:0000247
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
constant: false

metaR RE0383C
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reversible: true
name: RE0383
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_266a5c08_3402_4c04_81cd_d107ba0ae40c
constant: false
initial amount: NaN
is: Q99798
name: ACO2
is encoded by: hsa:50
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_01a29b34_00a9_4bc7_ae52_bbe76f88f0eb
type: Species
name: ACAT1
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:38
is: SBO:0000252
constant: false
is: P24752

metaR ALASERNaEx
kinetic law: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)

http://identifiers.org/biomodels.db/MODEL1310110049#_5d6c85b8_b161_4d35_9fe2_8e7d78d57b17
initial concentration: NaN
is: P07864
initial amount: NaN
has only substance units: false
name: LDHC
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3948

metaR FE3R2e
reversible: false
kinetic law: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
fast: false
product: MODEL1310110049#
type: Reaction
name: Fe(III) reduction (ascorbate)
reactant: MODEL1310110049#
is described by: ECO:0000269

metaR PUNP5
reversible: true
name: purine-nucleoside phosphorylase (Inosine)
is described by: ECO:0000269
fast: false
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

metaR RE2079R
kinetic law: MODEL1310110049#
name: RE2079
fast: false
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reactant: MODEL1310110049#
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaR 4PYRDX
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
fast: false
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110049#
name: 4-Pyridoxal secretion
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000

metaM dad 2 e
is: HMDB00101
is: CHEBI:17256
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
name: 2-deoxyadenosine

metaR URIt5le
reversible: false
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000134
product: MODEL1310110049#
is: SBO:0000185

metaM ksi pre30 g
boundary condition: false
constant: false
is: HMDB00175
is: C00130
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 30
initial concentration: 1.0
type: Species
has only substance units: false

metaM cholate c
name: Cholate
initial amount: NaN
is: CHEBI:29747
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619

metaR ADNK3
product: MODEL1310110049#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110049#
name: adenosine kinase
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
is: SBO:0000176
reversible: false

metaR PYDAMtr
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
reversible: true
name: pyridoxamine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
fast: false

metaR r1400
is described by: ECO:0000000
name: Active transport
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000185

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_beb77d84_8fcc_4cd1_933c_3b9bb578a71a
initial concentration: NaN
initial amount: NaN
is: P09917
name: ALOX5
boundary condition: true
has only substance units: false
is encoded by: hsa:240
type: Species
constant: false
is: SBO:0000252

metaR PUNP6
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110049#
name: purine-nucleoside phosphorylase (Deoxyinosine)
kinetic law: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_b31018c1_7494_4bd0_beaf_3fdea8000e7c
boundary condition: true
has only substance units: false
name: _AI697028_1_m
initial amount: NaN
is encoded by: hsa:AI697028
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
constant: false
type: Species
is: HMDB00257
initial amount: NaN
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
boundary condition: false
is: CHEBI:16094
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_8a04b1e0_d834_4682_8055_398db73261e8
has only substance units: false
is: Q16836
is encoded by: hsa:3033
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: HADH
is: SBO:0000252
constant: false

metaR r0885
fast: false
modifier: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:

metaR DNDPt25m
modifier: MODEL1310110049#
is described by: ECO:0000269
fast: false
reversible: false
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000185
name: dTDP transport via dCDP antiport

metaR OCDCEAtr
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110049#

metaR RE3520E
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
type: Reaction
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.11.1.9
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: RE3520
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#

metaM ksii core4 pre4 g
boundary condition: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: HMDB00175
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 4
is: C00130
constant: false
is: CHEBI:58053
initial concentration: 1.0

metaR ADEt
modifier: MODEL1310110049#
reversible: true
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110049#
product: MODEL1310110049#
name: adenine reversible transport, cytosol
type: Reaction
is: SBO:0000185

metaM sphings l
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: sphingosine(1+)
is: CHEBI:57756
initial amount: NaN
constant: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: HMDB00252
type: Species
boundary condition: false

metaM pail4p hs c
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
boundary condition: false
is: CHEBI:58178
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaM o2 c
initial amount: NaN
type: Species
is: HMDB01377
is: C00007
has only substance units: false
constant: false
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: O2

metaM leuktrA4 c
type: Species
name: leukotriene A4(1-)
is: HMDB01337
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57463
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r0475
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#

metaR RE1531M
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: RE1531
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR H3MTer U
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
name: H3 mannosyltransferase, endoplasmic reticulum
reversible: false
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#

metaM dpcoa e
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: HMDB01373
name: Dephospho-CoA
is: CHEBI:57328
is: SBO:0000247
constant: false
has only substance units: false
is: C00882
initial concentration: 1.0
type: Species
initial amount: NaN

metaR PUNP1
is described by: ECO:0000269
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: purine-nucleoside phosphorylase (Adenosine)
type: Reaction
fast: false

metaM gacpail hs r
initial concentration: 1.0
is: HMDB01401
is: SBO:0000247
type: Species
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
is: C00092
boundary condition: false
initial amount: NaN
constant: false

metaR r0587
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
reversible: true
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_e48cacac_be39_4950_b40e_16a331d88a5b
boundary condition: true
name: DAD1:DDOST:RPN1:RPN2
has only substance units: false
constant: false
is encoded by: hsa:1603
is encoded by: hsa:1650
has part: P04844
is encoded by: hsa:6185
type: Species
has part: Q53G02
has part: P39656
has part: P04843
is encoded by: hsa:6184
initial amount: NaN
is: SBO:0000297
initial concentration: NaN

metaM 3hmp m
initial amount: NaN
is: HMDB00023
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
has only substance units: false
name: 3-hydroxy-2-methylpropanoate
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:11805

metaM ksi pre33 g
initial amount: NaN
is: HMDB00175
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 33
constant: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: CHEBI:58053
initial concentration: 1.0

metaR RE1447N
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
fast: false
is: SBO:0000176
name: RE1447
product: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR NMNATr
reversible: true
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
reactant: MODEL1310110049#
name: nicotinamide-nucleotide adenylyltransferase
modifier: MODEL1310110049#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_032f5b40_ae13_4f91_a505_27b025286cff
name: _D87002_1_m
constant: false
has only substance units: false
is encoded by: hsa:D87002
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaM C04849 e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
is: CHEBI:57449

http://identifiers.org/biomodels.db/MODEL1310110049#_9321ec73_9ac0_47eb_9903_d45f3a51d78f
is: Q96AT9
is encoded by: hsa:6120
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: RPE
is: SBO:0000252

metaR PUNP2
reversible: true
product: MODEL1310110049#
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaM o2 e
is: HMDB01377
is: C00007
constant: false
type: Species
is: CHEBI:15379
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: O2

metaM leuktrA4 e
name: leukotriene A4(1-)
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57463
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01337
type: Species

metaM apoC Lys c
is: CHEBI:32551
name: Apocarboxylase (Lys residue)
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H13N2OX CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: HMDB00182
has only substance units: false
constant: false

metaR r0196
type: Reaction
reversible: true
modifier: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110049#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110049#

metaR Q10H2e
is described by: ECO:0000134
type: Reaction
name: transport of ubiquinol into lymph
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reversible: true

metaR VALt5m
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110049#
name: Valine reversible mitochondrial transport
product: MODEL1310110049#
fast: false
is: SBO:0000185
reversible: true

metaR H4ETer
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110049#_5f0dcd98_633e_4f42_a53d_63433558a622
initial concentration: NaN
is encoded by: hsa:343
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: O94778
name: AQP8
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_fe74cf89_d508_4ef3_8bf4_c9e4a0c64a3d
initial concentration: NaN
constant: false
boundary condition: true
name: PRDX1
initial amount: NaN
is: Q06830
is encoded by: hsa:5052
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_de798c7c_e822_45a3_b24a_3c7844f878e6
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: Q5JRA6
is encoded by: hsa:375056
constant: false
initial concentration: NaN
name: MIA3

http://identifiers.org/biomodels.db/MODEL1310110049#_a4a44eb6_fa11_4ae0_b49e_9021a213ea8c
initial concentration: NaN
initial amount: NaN
constant: false
name: DGKE
type: Species
boundary condition: true
has only substance units: false
is: A1L4Q0
is encoded by: hsa:8526
is: SBO:0000252

metaR AICARte
product: MODEL1310110049#
type: Reaction
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110049#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

http://identifiers.org/biomodels.db/MODEL1310110049#_31197903_148b_4dbc_8ec2_ede2129d942c
type: Species
initial concentration: NaN
is encoded by: hsa:1375
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: CPT1B
initial amount: NaN
is: Q92523

metaR RE1447M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
name: RE1447
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:

metaR LEUTA
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
modifier: MODEL1310110049#
is: SBO:0000176
fast: false
name: leucine transaminase
is described by: ECO:0000269
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR S6T16g
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#

metaR MEVK1c
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
name: mevalonate kinase (atp) cytosol
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.36

metaM ppa e
name: propionate
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
is: CHEBI:17272
initial amount: NaN
initial concentration: 1.0
is: HMDB00237
type: Species
constant: false
boundary condition: false

metaR r0191
type: Reaction
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.24
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_3e071844_d72f_4d90_b50b_bbcd7d4d947a
is encoded by: hsa:111
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: O95622
boundary condition: true
constant: false
has only substance units: false
name: ADCY5

http://identifiers.org/biomodels.db/MODEL1310110049#_84732a6f_eec2_493b_8eb6_5a4a46adf717
is: SBO:0000252
is: Q03393
initial amount: NaN
constant: false
name: PTS
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5805

metaR TTDCAFATPc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_611d0848_b36c_4a75_8626_0700641abddc
constant: false
is: SBO:0000252
type: Species
name: G6PC
initial amount: NaN
boundary condition: true
is encoded by: hsa:2538
has only substance units: false
is: P35575
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_926a77b7_a855_415a_8958_11f7a72a94c6
name: RDH11
initial amount: NaN
type: Species
boundary condition: true
is: B4DDW0
is: SBO:0000252
is encoded by: hsa:51109
constant: false
initial concentration: NaN
has only substance units: false

metaM malttr e
initial amount: NaN
is: C01835
is: HMDB01262
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:27931
name: maltotriose

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM galacglcgalgbside hs e
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
is: CHEBI:0
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Gal-GlcNAc-Gal globoside
is: HMDB00143
is: C00124
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_964f7340_a114_4a0e_9d3e_5f83997b1ce3
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: _M68895_1_c
is encoded by: hsa:M68895
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_2c3c4068_2449_4b48_90d6_a6a445dad377
initial amount: NaN
name: AADAT
is: SBO:0000252
has only substance units: false
is: Q4W5N8
is encoded by: hsa:51166
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR M1316Mg
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
kinetic law: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.114
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176

metaR NADtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
product: MODEL1310110049#
name: transport of NAD into peroxisome
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM 4abut c
type: Species
is: HMDB00112
is: CHEBI:3628
boundary condition: false
constant: false
initial concentration: 1.0
name: 4-Aminobutanoate
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR r0584
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaM gdp c
constant: false
name: GDP
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00035
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
has only substance units: false
is: HMDB01201
is: SBO:0000247

metaM glyald c
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
boundary condition: false
is: HMDB01051
is: SBO:0000247
type: Species
has only substance units: false
is: C00577
initial concentration: 1.0
is: CHEBI:17378
name: D-Glyceraldehyde

metaR MTHFD
product: MODEL1310110049#
name: methylenetetrahydrofolate dehydrogenase (NADP)
is: SBO:0000176
reactant: MODEL1310110049#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is described by: ECO:0000134
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.5.1.5

http://identifiers.org/biomodels.db/MODEL1310110049#_20609ab8_9131_4150_aa7c_310a9feef706
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: PLA2G2A
initial concentration: NaN
constant: false
is encoded by: hsa:5320
is: P14555

http://identifiers.org/biomodels.db/MODEL1310110049#_e01fea1c_4725_40b8_8b86_aab060ae47e9
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: LYZL1
type: Species
is: SBO:0000252
is encoded by: hsa:84569
is: Q6UWQ5

metaR HIBDm
reversible: true
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
fast: false
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.31
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is described by: ECO:0000269

metaR r0193
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
type: Reaction

metaM m8mpdol L r
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:59093
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868

metaM ksi pre25 g
is: SBO:0000247
is: C00130
has only substance units: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
type: Species
is: CHEBI:58053
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 25
is: HMDB00175

metaM ctp c
type: Species
constant: false
boundary condition: false
is: HMDB00082
initial amount: NaN
name: CTP
initial concentration: 1.0
has only substance units: false
is: CHEBI:37563
is: C00063
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_2c09d3bf_8485_4307_aeae_d76bab359330
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:NOS2A
constant: false
is: SBO:0000252
name: _NOS2A_1_c
boundary condition: true
type: Species

metaM oxa m
has only substance units: false
is: CHEBI:30623
constant: false
type: Species
initial amount: NaN
name: oxalate(2-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR ARACHt
type: Reaction
reactant: MODEL1310110049#
name: fatty acid transport via diffusion
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_dc4254d2_e3f3_43ae_aa31_2b21b4372c52
initial amount: NaN
constant: false
name: ECI1
is encoded by: hsa:1632
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P42126
type: Species
initial concentration: NaN

metaR ALAASNNaEx
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110049#
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110049#
reversible: false
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_f171bb12_7c43_4739_aecc_8a8f6dc41d3e
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10588
constant: false
is: P49914
initial amount: NaN
initial concentration: NaN
name: MTHFS
type: Species

metaM galacglcgalgbside hs c
has only substance units: false
initial amount: NaN
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
type: Species
initial concentration: 1.0
is: HMDB00061
constant: false
name: Gal-GlcNAc-Gal globoside
is: SBO:0000247
is: CHEBI:58343
boundary condition: false

metaR C3STKR2r
reversible: false
name: C-3 sterol keto reductase (zymosterol)
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110049#
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_8d43bd11_450c_4059_8846_e19122daecda
name: NMNAT2
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:23057
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_40ec094f_8615_488b_9e0c_e1fa719124c0
type: Species
is: Q16790
boundary condition: true
has only substance units: false
is encoded by: hsa:768
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: CA9

metaM sphings c
has only substance units: false
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: HMDB00252
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57756
constant: false
initial amount: NaN
name: sphingosine(1+)

metaR ATPtx
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: ATP transporter, peroxisomal

metaR UREAt5
reactant: MODEL1310110049#
is: SBO:0000185
name: urea, water cotransport
kinetic law: MODEL1310110049#
is described by: ECO:0000269
fast: false
reversible: true
modifier: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD

metaR TRPHYDRO2
reversible: false
modifier: MODEL1310110049#
type: Reaction
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
reactant: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.16.4
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1

http://identifiers.org/biomodels.db/MODEL1310110049#_039d8242_ca44_4498_add3_7e8c8df3d561
constant: false
initial amount: NaN
is encoded by: hsa:AA081045
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AA081045_1_c

metaM 4abut e
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00334
name: 4-Aminobutanoate
is: HMDB00112
is: CHEBI:3628
has only substance units: false
type: Species

metaR C4STMO2Pr
is version of: http://identifiers.org/ec-code/1.1.1.170
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is described by: ECO:0000000
type: Reaction
name: C-4 methyl sterol oxidase

http://identifiers.org/biomodels.db/MODEL1310110049#_04b560bf_7108_4cf9_8f80_2b2c3efb0314
name: OXSM
is: SBO:0000252
is encoded by: hsa:54995
type: Species
is: Q9NWU1
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaM pydam c
is: SBO:0000247
type: Species
is: CHEBI:57761
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: HMDB01431
name: Pyridoxamine
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: C00534

metaR UDPG4E
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
name: UDPglucose 4-epimerase
is described by: ECO:0000134
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
fast: false

metaR PUNP7
is described by: ECO:0000269
reversible: true
name: purine-nucleoside phosphorylase (Xanthosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#

metaM ctp e
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00082
name: CTP(4-)

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaR MTHFC
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110049#
reversible: true

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR r0580
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.7
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
modifier: MODEL1310110049#
type: Reaction
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_5ffa0798_c7bc_43ec_8a07_486ddaf446f6
has only substance units: false
name: ST3GAL3
constant: false
type: Species
is encoded by: hsa:6487
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR DNDPt36m
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
type: Reaction
modifier: MODEL1310110049#
name: dGDP transport via dCDP antiport
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false

metaM man1p c
is: HMDB06330
initial concentration: 1.0
is: CHEBI:35374
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636

metaM pydam e
is: HMDB01431
type: Species
is: CHEBI:57761
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
initial amount: NaN
constant: false
name: Pyridoxamine
has only substance units: false
is: C00534
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR FUCASEly
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110049#
fast: false
name: alpha-fucosidase, lysosomal
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.51

http://identifiers.org/biomodels.db/MODEL1310110049#_235d59b9_36d1_4623_848d_0fe7dd5c9c4b
is encoded by: hsa:10637
has only substance units: false
constant: false
name: LEFTY1
type: Species
is: O75610
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR r1088
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true
product: MODEL1310110049#
name: Active transport

metaM dpcoa m
is: HMDB01373
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
is: SBO:0000247

metaR ME2m
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
name: malic enzyme (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.40
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is described by: ECO:0000000
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.38
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_b92b89bd_4fa9_4be6_b07e_8a8c75df70ec
initial concentration: NaN
is: SBO:0000252
name: PPA2
has only substance units: false
is encoded by: hsa:27068
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR NAGAlby
reversible: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
fast: false
name: N-acetylgalactosaminidase, beta-
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
type: Reaction
is described by: ECO:0000000

metaM dag hs r
is: SBO:0000247
is: CHEBI:18035
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_564dcae1_7a25_4f15_bb34_17cb4dd76953
is: P36021
name: SLC16A2
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6567
initial amount: NaN

metaM thcholoylcoa x
is: CHEBI:27403
has only substance units: false
type: Species
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
boundary condition: false
is: HMDB12456
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_613beb37_437d_42e6_96d4_632029eefe52
is encoded by: hsa:1384
initial amount: NaN
is: SBO:0000252
name: CRAT
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_aa8bd0f2_0b45_4072_8acf_e093af0efb65
initial amount: NaN
is encoded by: hsa:2348
boundary condition: true
has only substance units: false
name: FOLR1
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r0734
product: MODEL1310110049#
reactant: MODEL1310110049#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reversible: false

metaR DOLP Lter
reactant: MODEL1310110049#
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
name: dolichol phosphate flippase (liver)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110049#
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_ad8d201b_4380_433b_8ec9_ca237aa4da8e
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has part: Q6IB54
is: SBO:0000297
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
type: Species

metaM ipdp c
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:128769
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: Isopentenyl diphosphate
is: C00129
is: HMDB01347
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_d5941db9_563d_43c6_9cf3_ce308f7c3ab1
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9UN76
type: Species
is encoded by: hsa:11254
boundary condition: true
name: SLC6A14

metaR URIK1
is version of: http://identifiers.org/ec-code/2.7.1.48
type: Reaction
reactant: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
name: uridine kinase (ATP:Uridine)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is: SBO:0000176
product: MODEL1310110049#
fast: false

metaM prostgf2 c
initial amount: NaN
is: SBO:0000247
name: prostaglandin F2alpha(1-)
type: Species
initial concentration: 1.0
is: HMDB01139
is: CHEBI:57404
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
boundary condition: false
constant: false

metaR r0735
modifier: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176

metaR NDPK7n
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is described by: ECO:0000304
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110049#
reversible: true

metaM tymsf c
type: Species
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
boundary condition: false
is: HMDB06409
name: Tyramine O-sulfate
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_e5eda32c_2c68_471e_8260_b9fb03e09db6
has only substance units: false
is: SBO:0000252
name: DGKB
is encoded by: hsa:1607
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q9Y6T7

metaR GALASE8ly
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110049#

metaM xol7ah2al c
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06894
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247
type: Species
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false

metaR NACHEX25ly
is described by: ECO:0000000
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false
kinetic law: MODEL1310110049#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_a006b576_8c89_4257_8d42_d268efbfb297
initial amount: NaN
has only substance units: false
boundary condition: true
name: _LOC727762_1_m
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:LOC727762

metaM ncam c
is: HMDB01406
is: CHEBI:0
boundary condition: false
initial amount: NaN
name: Nicotinamide
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H6N2O CHARGE: 0
is: SBO:0000247
is: C00153
has only substance units: false

metaM maltttr e
type: Species
initial amount: NaN
is: HMDB01296
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: http://identifiers.org/pubchem.compound/5141
name: Maltotetraose
initial concentration: 1.0
is: C02052

metaM malthp e
initial concentration: 1.0
name: maltoheptaose
is: SBO:0000247
is: C01936
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
constant: false

metaM ttdca c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:30807
boundary condition: false
name: myristate
constant: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: HMDB00806
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_ec867824_f88e_43cd_8adf_7ed6e41db3aa
initial amount: NaN
is: Q9NVE7
name: PANK4
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55229

metaM HC01412 m
is: CHEBI:61405
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
constant: false
has only substance units: false
name: trans-tetradec-2-enoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_e708a2ed_bc73_419e_99de_fd3e6049a00d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:26275
initial amount: NaN
constant: false
type: Species
is: Q6NVY1
has only substance units: false
is: SBO:0000252
name: HIBCH

metaR r0021
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110049#
reversible: true
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_36259f84_f3c6_4704_8194_169bab231b09
initial concentration: NaN
is: SBO:0000252
name: COX1
constant: false
type: Species
initial amount: NaN
is: Q7GXY8
is encoded by: hsa:4512
has only substance units: false
boundary condition: true

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR LNLCCPT1
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110049#

metaR r0732
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110049#
reversible: false
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR INSt
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
kinetic law: MODEL1310110049#
is described by: ECO:0000269
reversible: true
product: MODEL1310110049#
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
name: Inosine transport (diffusion)
modifier: MODEL1310110049#

metaR MAN6PI
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: true
name: mannose-6-phosphate isomerase
is described by: ECO:0000304
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.3.1.8
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#

metaM ksii core2 l
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
has only substance units: false
name: keratan sulfate II (core 2-linked)
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57614
initial concentration: 1.0
is: HMDB00189

metaM tymsf e
is: HMDB06409
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
boundary condition: false
name: Tyramine O-sulfate
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR r0022
type: Reaction
modifier: MODEL1310110049#
reversible: true
product: MODEL1310110049#
is: SBO:0000176
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_b1db125a_14fa_48e9_b232_ca47c6ecf79d
constant: false
name: NDUFA13
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51079
is: Q9P0J0

metaR DURIt
is: SBO:0000185
is described by: ECO:0000000
name: deoxyuridine transport via diffusion
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true

metaM xol27oh m
is: HMDB02103
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
is: CHEBI:17703
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 26-hydroxycholesterol
constant: false

metaR FADH2ETC
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: Complex II reaction for respiratory chain

metaR DRIBt
name: deoxyribose transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
type: Reaction

metaM gdpmann c
initial concentration: 1.0
constant: false
is: CHEBI:57527
has only substance units: false
is: HMDB01163
is: SBO:0000247
boundary condition: false
name: GDP-alpha-D-mannose(2-)
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
type: Species
initial amount: NaN

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_921579c3_ae9f_4619_a168_6fb2e5d4969a
is: P49448
is encoded by: hsa:2747
name: GLUD2
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaR r0733
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: false
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false

metaR LNLCCPT2
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
product: MODEL1310110049#
name: carnitine transferase

metaM oxa c
has only substance units: false
initial concentration: 1.0
is: CHEBI:30623
name: oxalate(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
constant: false
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110049#_f7982442_1bb3_4a62_82a7_d620c3d5b6dc
is: O95168
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4710
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFB4

metaR r0027
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.14.13.39
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:

metaR SPMTDe
product: MODEL1310110049#
is described by: ECO:0000134
type: Reaction
name: SPMTDe
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR r2319
type: Reaction
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_9a1aa193_f8e4_4f14_8d1b_961aff709086
is: Q8IYH3
initial concentration: NaN
boundary condition: true
name: HAS1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3036
type: Species
constant: false

metaR r0730
type: Reaction
kinetic law: MODEL1310110049#
reversible: false
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_0ffa1243_85aa_4e1b_89f7_84d3b50c80a3
initial amount: NaN
is: P21912
boundary condition: true
is encoded by: hsa:6390
name: SDHB
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_245819a6_9b09_4ddb_a7df_d7cedf40794e
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q96PE7
is encoded by: hsa:84693
constant: false
name: MCEE
has only substance units: false
type: Species
initial amount: NaN

metaR DOPAtu
fast: false
is described by: ECO:0000269
modifier: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
name: Dopamine uniport
type: Reaction
kinetic law: MODEL1310110049#

metaR M4MPDOL Lter
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: m4mpdol flippase

metaR B3GNT310g
kinetic law: MODEL1310110049#
type: Reaction
reversible: false
product: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000254
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reactant: MODEL1310110049#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110049#_2c5dacb1_58ea_4892_8e4c_1a92c427e65b
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: E9KL48
is encoded by: hsa:2746
constant: false
boundary condition: true
name: GLUD1

metaR r1148
kinetic law: MODEL1310110049#
is: SBO:0000185
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110049#
type: Reaction
reversible: true
name: Active transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_0884da5c_0fa9_4b52_b36a_ae6b798d65fe
name: FUT8
constant: false
is: Q546E0
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2530
initial amount: NaN
type: Species

metaR r2318
kinetic law: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000000

metaR r0731
is: SBO:0000176
reactant: MODEL1310110049#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false

metaR PDE1
kinetic law: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.4.17
is version of: http://identifiers.org/ec-code/3.1.4.35
is: SBO:0000176
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_ab47649b_c154_4c42_9402_7be4c650a475
constant: false
boundary condition: true
name: CA12
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: O43570
has only substance units: false
is encoded by: hsa:771

metaR 34DHXMANDACOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase

metaR r2317
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110049#

metaM ctp n
is: CHEBI:37563
name: CTP(4-)
is: HMDB00082
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM thcrm hs g
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:24636
name: trihexosyl ceramide
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110049#_c46cf2f4_e490_478a_92d2_8d280c7a437e
initial amount: NaN
is encoded by: hsa:221
has only substance units: false
name: ALDH3B1
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: P43353

metaR r2030
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
reversible: false
product: MODEL1310110049#
is: SBO:0000185

metaR r1147
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110049#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_7f004463_18c8_4a70_a84f_c6c737ba01ab
initial amount: NaN
type: Species
is: Q9NS18
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51022
name: GLRX2
boundary condition: true

metaM galacglcgalgbside hs g
type: Species
name: Gal-GlcNAc-Gal globoside
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:26174
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0

metaR r1090
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaR DOLPMT3 Uer
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: false
fast: false

metaM prostgf2 e
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
is: HMDB01139
boundary condition: false
is: CHEBI:57404
type: Species
name: prostaglandin F2alpha(1-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR DOLPGT1 Ler
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.267
is described by: ECO:0000000
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reversible: false

metaR r0139
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
reversible: true
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110049#_2f1e815d_2403_4889_9db3_bea832060969
has only substance units: false
is encoded by: hsa:18
boundary condition: true
initial amount: NaN
name: ABAT
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: P80404

metaM ppa c
initial amount: NaN
initial concentration: 1.0
is: HMDB00237
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
boundary condition: false
name: propionate
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_0033f7b8_5cc7_47e9_84ed_018633ac6eac
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _AU149534_1_m
constant: false
is encoded by: hsa:AU149534

http://identifiers.org/biomodels.db/MODEL1310110049#_356495fa_adeb_4e33_9007_c239651218ed
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: SLC6A9
has only substance units: false
is encoded by: hsa:6536
is: SBO:0000252
boundary condition: true
is: P48067

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_d4811627_b330_40ce_adea_5e7cbdbf07e9
initial amount: NaN
name: DGUOK
has only substance units: false
is encoded by: hsa:1716
is: SBO:0000252
type: Species
is: Q16854
boundary condition: true
initial concentration: NaN
constant: false

metaM Lkynr c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: HMDB00684
has only substance units: false
initial amount: NaN
is: CHEBI:16946
name: L-kynurenine
is: SBO:0000247
constant: false
type: Species

metaR HPYRR2x
is: SBO:0000176
name: hydroxypyruvate reductase (NADH)
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110049#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.2.4
product: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
fast: false

metaR NDP7g
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
is: SBO:0000176
product: MODEL1310110049#
reversible: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_36a06e14_f13b_44ea_8ea0_7199449760f3
type: Species
boundary condition: true
is: SBO:0000252
is: Q8N3E9
constant: false
is encoded by: hsa:113026
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PLCD3

metaM ksii core2 e
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: HMDB00211
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:17268
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_8c6879ae_e727_49d5_8cba_917a4e6a1eec
type: Species
initial amount: NaN
is encoded by: hsa:4706
initial concentration: NaN
is: O14561
constant: false
boundary condition: true
name: NDUFAB1
has only substance units: false
is: SBO:0000252

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR r2315
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM dag hs c
initial concentration: 1.0
is: CHEBI:18035
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5630f6cd_d333_4eb4_a623_3e89dfc868da
name: AK4
is encoded by: hsa:205
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM ksii core2 pre3 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial amount: NaN
boundary condition: false
is: HMDB00175
is: CHEBI:58053
type: Species
name: keratan sulfate II biosynthesis, precursor 3
is: C00130
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ad7238d7_80ff_49dc_8cb5_7029480d70d6
is encoded by: hsa:1891
boundary condition: true
is: Q13011
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ECH1

http://identifiers.org/biomodels.db/MODEL1310110049#_051a00ac_f446_4142_95bc_418cb4fb55e8
has only substance units: false
is: P13686
type: Species
name: ACP5
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:54

http://identifiers.org/biomodels.db/MODEL1310110049#_95e959fe_068a_4d10_84f6_0deae3fcb974
initial amount: NaN
is: P31645
type: Species
name: SLC6A4
has only substance units: false
is encoded by: hsa:6532
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r0892
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110049#
product: MODEL1310110049#
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.2.27
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_f06aee60_39b6_42b9_a454_5cdb7a5f5e25
name: PIGB
initial concentration: NaN
is encoded by: hsa:9488
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: Q92521

http://identifiers.org/biomodels.db/MODEL1310110049#_0e1bb313_40f2_4b09_bdcb_4ecabe421554
type: Species
is encoded by: hsa:285973
is: Q674R7
name: ATG9B
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaR r2314
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000000

metaR NADPHtru
product: MODEL1310110049#
name: NADPH transporter, endoplasmic reticulum
fast: false
reactant: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000185

metaM CE5161 r
is: HMDB00127
type: Species
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
initial amount: NaN
boundary condition: false
is: CHEBI:15748
initial concentration: 1.0
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA

metaR OCTAt
product: MODEL1310110049#
name: Octanoate transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110049#
fast: false
reversible: true

metaM ksi pre17 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 17
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: SBO:0000247
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110049#_588a2707_e6ef_44ce_bdf1_71a7d6308e04
constant: false
type: Species
is encoded by: hsa:4712
is: O95139
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: NDUFB6

http://identifiers.org/biomodels.db/MODEL1310110049#_49b1e94d_44f9_4550_b691_56c35a62b11a
boundary condition: true
has only substance units: false
initial amount: NaN
is: P51828
name: ADCY7
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:113
constant: false

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR r2313
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR P5CDm
product: MODEL1310110049#
modifier: MODEL1310110049#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000269
reversible: false

metaM n2m2nmasn l
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
is: C04946
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_f0896fc8_d02b_4efe_8a5d_fbf9c78ebe32
is: O95139
name: NDUFB6
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4712
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR S6TASE22ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110049#
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110049#
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110049#_98c02f4d_9199_486b_9ffd_aefc43b9bdc3
boundary condition: true
is encoded by: hsa:92579
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: G6PC3
type: Species
constant: false
has only substance units: false
is: Q9BUM1

metaM HC02180 c
type: Species
boundary condition: false
name: thromboxane-b2
has only substance units: false
is: SBO:0000247
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_135ba407_25eb_470c_9c6e_bc970cbb7a4e
initial amount: NaN
boundary condition: true
is encoded by: hsa:1329
has only substance units: false
type: Species
name: COX5B
is: Q53YB7
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_0481211a_6b02_4ac5_bf17_0b9abbdcb235
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2030
is: Q99808
initial concentration: NaN
initial amount: NaN
name: SLC29A1
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_9e01bdb8_fb0d_4ac0_bce0_77d8cc40c534
is: Q96T66
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: NMNAT3
initial concentration: NaN
is encoded by: hsa:349565
boundary condition: true
constant: false
type: Species

metaR r2312
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
type: Reaction

metaR THRD L
name: L-threonine deaminase
product: MODEL1310110049#
is: SBO:0000176
reversible: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.3.1.17
type: Reaction
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....

metaR DNDPt26m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
name: dCDP transport via dUDP antiport
type: Reaction
is: SBO:0000185
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_f1e7fd66_a88a_4d2a_8b17_2c1175759113
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8525
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: DGKZ
has only substance units: false
is: B7Z2M9

metaR MG3er
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110049#

metaM octa c
is: C06423
is: CHEBI:25646
name: octanoate (n-C8:0)
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H15O2 CHARGE: -1
has only substance units: false
constant: false
is: HMDB00482

http://identifiers.org/biomodels.db/MODEL1310110049#_020bc4f9_4479_44ab_8dbd_996f550a7851
initial concentration: NaN
has only substance units: false
type: Species
name: NT5C2
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:22978
is: P49902

metaM 3hpcoa m
boundary condition: false
name: 3-hydroxypropanoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
constant: false
is: SBO:0000247
is: HMDB06807
is: CHEBI:58528

metaM ile L c
is: SBO:0000247
initial concentration: 1.0
name: L-isoleucine
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00172
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191

metaR r2311
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_96520cb7_de27_41ca_9b65_1fa197843d42
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2530
initial concentration: NaN
is: G3V5N0
initial amount: NaN
name: FUT8
boundary condition: true
constant: false

metaR GALSIDEtl
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
reversible: true
name: galactocerebroside intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is described by: ECO:0000000

metaR RE2069C
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
kinetic law: MODEL1310110049#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110049#
is: SBO:0000176
name: RE2069

metaR NRPPHRSFt
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
type: Reaction
name: norepinephrine sulfate transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaR G14T14g
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_3e7ec5f0_12c6_4d84_a9b3_00fb4f62118c
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q96RQ3
has only substance units: false
name: MCCC1
constant: false
type: Species
is encoded by: hsa:56922

metaM n2m2nmasn e
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: C04946
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

http://identifiers.org/biomodels.db/MODEL1310110049#_440c9b1d_23a2_48cc_a4dd_3ebfe04393a2
is: Q6IB80
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4709
name: NDUFB3
initial amount: NaN
type: Species
initial concentration: NaN

metaR ENGASE3ly
kinetic law: MODEL1310110049#
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_d62f3fd5_f744_4595_aca4_0f864e4a1bc7
initial amount: NaN
is: Q8TB61
constant: false
boundary condition: true
name: SLC35B2
is: SBO:0000252
is encoded by: hsa:347734
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_5bd984a3_5ced_430e_a823_c93b3f802d6d
is: P35754
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: GLRX
initial amount: NaN
is encoded by: hsa:2745
initial concentration: NaN

metaR r2310
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_6c3709cf_6da4_48b1_98ce_5af09819b6b6
has only substance units: false
is encoded by: hsa:55350
initial concentration: NaN
name: VNN3:VNN2:VNN1
has part: O95497
is: SBO:0000297
boundary condition: true
is encoded by: hsa:8875
initial amount: NaN
is encoded by: hsa:8876
has part: A8K7W0
type: Species
constant: false

metaM octa e
constant: false
initial amount: NaN
initial concentration: 1.0
name: octanoate (n-C8:0)
is: C06423
is: CHEBI:25646
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
is: HMDB00482
boundary condition: false

metaM xol27oh r
has only substance units: false
is: HMDB02103
is: CHEBI:17703
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: SBO:0000247
name: 26-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110049#_e05f7e17_f37b_40e7_9cb7_3b16141e0bca
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PDE3B
initial amount: NaN
is: A7E2E5
type: Species
has only substance units: false
constant: false
is encoded by: hsa:5140

metaR r0130
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true
modifier: MODEL1310110049#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaM ksii core2 g
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
has only substance units: false
is: CHEBI:57614
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
is: HMDB00189
constant: false
type: Species

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
name: L-isoleucine
is: HMDB00172
has only substance units: false
is: CHEBI:17191
boundary condition: false
is: SBO:0000247

metaR UAGDP
reversible: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
fast: false
name: UDP-N-acetylglucosamine diphosphorylase
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.23
modifier: MODEL1310110049#

metaM apoC Lys m
type: Species
name: Apocarboxylase (Lys residue)
is: HMDB00182
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: CHEBI:32551
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM ncam e
is: CHEBI:0
initial concentration: 1.0
notes: FORMULA: C6H6N2O CHARGE: 0
name: Nicotinamide
type: Species
is: C00153
constant: false
initial amount: NaN
is: HMDB01406
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM n2m2nmasn g
is: C04946
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
initial amount: NaN
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaR 4MOPt2im
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110049#
fast: false
type: Reaction

metaR r1259
kinetic law: MODEL1310110049#
type: Reaction
reversible: false
name: EC:6.2.1.3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110049#
product: MODEL1310110049#

metaR URATEt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110049#
is: SBO:0000185
reversible: false
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
name: urate export from cytosol

metaR r0579
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
product: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.13.11.19

metaR GLNALANaEx
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
reactant: MODEL1310110049#

metaM retinal cis 13 r
has only substance units: false
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
name: 13-cis-retinal
constant: false
initial concentration: 1.0
is: CHEBI:45487
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB06220

metaM didp c
initial concentration: 1.0
constant: false
name: dIDP
is: HMDB03536
boundary condition: false
type: Species
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r2106
type: Reaction
product: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110049#_9aca69a8_9dbd_45eb_b650_27bfd977e76f
type: Species
name: PIGC
is encoded by: hsa:5279
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q92535
initial concentration: NaN
boundary condition: true
constant: false

metaM dgsn m
boundary condition: false
is: SBO:0000247
type: Species
is: C00330
constant: false
is: HMDB00085
name: Deoxyguanosine
initial amount: NaN
has only substance units: false
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_1df3de5a_5afe_4c3e_a731_3d9a542b4d44
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:LOC374569
is: SBO:0000252
boundary condition: true
constant: false
name: _LOC374569_1_e

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_c822000e_f30a_446b_8a4e_ebbbb8070ab1
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: SDHB
is: P21912
is encoded by: hsa:6390

http://identifiers.org/biomodels.db/MODEL1310110049#_3e5ca508_aa12_4706_abb1_c95851128a58
initial amount: NaN
constant: false
is encoded by: hsa:11000
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q5K4L6
name: SLC27A3
boundary condition: true
type: Species

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR PPCOAOm
is: SBO:0000176
product: MODEL1310110049#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR r0578
modifier: MODEL1310110049#
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.2.27
kinetic law: MODEL1310110049#

metaR r2107
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
fast: false
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_c6446e29_807b_4348_a130_a3f66a9a2bbf
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _W74642_1_c
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:W74642

metaM HC00591 m
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: 2-oxoglutaramate
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial concentration: 1.0
is: CHEBI:16769

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaR r1952
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_93f0510c_64b5_4f68_a2f9_efec0ccd8bd6
initial amount: NaN
type: Species
boundary condition: true
name: BDH1
initial concentration: NaN
has only substance units: false
constant: false
is: Q02338
is: SBO:0000252
is encoded by: hsa:622

metaR r2108
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_2a4bdc58_3919_4e27_b8ce_ac47066a95ee
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: B4GALT1
is encoded by: hsa:2683
is: P15291

metaM g2m8masn r
is: C05874
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_76da8036_532c_410c_a2b2_c849a9376a9c
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1103
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: CHAT
is: P28329

metaM mi34p c
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
constant: false
is: SBO:0000247
is: CHEBI:28858
type: Species
has only substance units: false
is: HMDB06235
name: 1D-myo-Inositol 3,4-bisphosphate
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_219ab71d_273e_4b6f_bc99_7ab788f1c151
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P41222
constant: false
is encoded by: hsa:5730
name: PTGDS
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_bfedaf21_aaa8_4671_a8b5_33b6855572a0
is: B2RDU6
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:4598
name: MVK
constant: false

metaR BTNt2
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
name: Biotin reversible transport via proton symport
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_6ecac2b9_fcd9_425b_a226_bf1b977be5ed
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: Q9NY65
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: EHHADH
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110049#_3bfa55b8_7953_499f_bf53_864fd05d125f
constant: false
is encoded by: hsa:6342
boundary condition: true
is: SBO:0000252
name: SCP2
is: C9JC79
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_04e8aa66_e23c_4288_ab09_4a4e749ba86f
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALDH2
constant: false
is: P05091
initial concentration: NaN
is encoded by: hsa:217

metaR GPDDA1
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: false
product: MODEL1310110049#

metaR r2109
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110049#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_b2611831_4e87_4691_93ff_4c2daf31b151
constant: false
boundary condition: true
is encoded by: hsa:4200
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P23368
name: ME2
has only substance units: false

metaR PTDCAt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110049#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction

metaM nadph x
is: SBO:0000247
is: C00005
is: HMDB00221
type: Species
is: CHEBI:57783
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM Rtotal2coa c
has only substance units: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00055
is: SBO:0000247
type: Species
is: CHEBI:60377
name: R total 2 coenzyme A
is: HMDB00095

metaR r2102
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000000

metaM HC02204 c
type: Species
name: prostaglandin-b1
is: CHEBI:27624
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959

metaR r0575
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_8d4e5448_4a41_4b75_9ff5_ca88110158ec
is: Q86WU2
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:197257
constant: false
is: SBO:0000252
name: LDHD

W3 CDTF: Thu Aug 30 20:40:55 BST 2012

metaR RE1897C
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
product: MODEL1310110049#
fast: false
type: Reaction
is described by: ECO:0000000
name: RE1897
reversible: true

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM ala B c
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00056
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
is: CHEBI:16958
type: Species
is: SBO:0000247
name: beta-alanine

http://identifiers.org/biomodels.db/MODEL1310110049#_74f0511e_5af4_4eb8_95ad_338fc5d9ef3c
is: SBO:0000252
name: _AV727634_1_c
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AV727634
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_6be074cf_4cc7_4f14_a133_72dd754a5d3a
initial concentration: NaN
is: B4DUY1
is encoded by: hsa:10948
is: SBO:0000252
type: Species
has only substance units: false
name: STARD3
constant: false
initial amount: NaN
boundary condition: true

metaM ditp c
constant: false
is: CHEBI:61382
is: HMDB03537
type: Species
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
name: dITP(4-)
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ac673485_e3bd_48b2_aa3c_ecedefb90102
initial amount: NaN
is encoded by: hsa:7084
type: Species
is: O00142
is: SBO:0000252
name: TK2
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR r2103
reactant: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_75415ee3_8ea9_4e1b_8135_2bd5f66b932d
initial concentration: NaN
name: PEMT
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:10400
has only substance units: false
initial amount: NaN
boundary condition: true

W3 CDTF: Thu Aug 30 20:40:55 BST 2012

metaR DADNt4
name: deoxyadenosine transport via diffusion
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
reversible: true
is described by: ECO:0000000
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_38e015b7_e8a1_497a_be3e_336c24203522
is encoded by: hsa:155184
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: Q6PXP3
name: SLC2A7

metaR RE1516M
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
name: RE1516
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
fast: false
reactant: MODEL1310110049#

metaM CE0785 m
is: CHEBI:57795
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
name: cis,cis-myristo-5,8-dienoyl-CoA
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR GALSIDEtg
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reactant: MODEL1310110049#
name: galactocerebroside intracellular transport

metaR CAATPS
name: Ca ATPase
is: SBO:0000185
fast: false
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
is version of: http://identifiers.org/ec-code/3.6.3.8
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269

metaM ksi pre32 g
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 32
is: CHEBI:28067
is: SBO:0000247

metaR r2104
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_c4bcee69_f6fd_4283_840e_76b9e64b01ea
is: B7Z5G2
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2629
name: GBA
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_f5b2e126_5844_499d_85cd_f739ab372596
has only substance units: false
initial concentration: NaN
constant: false
is: Q9UHI7
initial amount: NaN
type: Species
name: SLC23A1
boundary condition: true
is encoded by: hsa:9963
is: SBO:0000252

metaR B3GALT3g
reactant: MODEL1310110049#
type: Reaction
name: Beta-1,3-galactosyltransferase 3
is: SBO:0000176
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.79
modifier: MODEL1310110049#

metaR r0464
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_ed714ba3_6931_4ea9_8c85_7526dfbc4447
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:79901
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: B4DWD7
name: CYBRD1

http://identifiers.org/biomodels.db/MODEL1310110049#_127984d9_3a7a_4b5d_8674_fb0c44fc21a1
name: TST
is encoded by: hsa:7263
initial amount: NaN
is: Q16762
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57847
type: Species
has only substance units: false
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
is: SBO:0000247
constant: false
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
is: HMDB00304
boundary condition: false

metaR NACHEXA17ly
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reactant: MODEL1310110049#
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110049#

metaM retinol cis 11 c
is: CHEBI:16302
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 11-cis-retinol
is: HMDB06216

http://identifiers.org/biomodels.db/MODEL1310110049#_cfdc363d_fb14_44ef_b3d5_6188d2e0dedb
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: A0PJH2
is encoded by: hsa:10476
has only substance units: false
type: Species
name: ATP5H
initial amount: NaN
constant: false

metaR NACHEXA21ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
type: Reaction

metaM so3 c
initial amount: NaN
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
is: CHEBI:17137
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: Sulfite
boundary condition: false
is: HMDB00240

metaR r2105
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110049#_64292767_48a3_4860_a6b4_bc061369c1bf
is encoded by: hsa:5321
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: P47712
boundary condition: true
name: PLA2G4A

metaR r0463
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
kinetic law: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000

metaM ksi pre24 g
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 24
is: C00130
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
type: Species
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_0f282800_ea07_4d23_aa18_10a05ed21266
initial amount: NaN
boundary condition: true
name: INPP4A
is encoded by: hsa:3631
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q96PE3

metaR S6T17g
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reversible: false
product: MODEL1310110049#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false

metaR GLYCTDle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000134
kinetic law: MODEL1310110049#
is: SBO:0000185
name: difussion of glycerol accross the brush border membrane
product: MODEL1310110049#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_0a71da32_5c83_46a3_aae6_bc71b472b206
is encoded by: hsa:AI222095
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: _AI222095_1_m
has only substance units: false

metaM glygn4 e
notes: FORMULA: C18H31O16X CHARGE: 0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00122
constant: false
initial amount: NaN
is: CHEBI:4167
initial concentration: 1.0
type: Species
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})

http://identifiers.org/biomodels.db/MODEL1310110049#_caf407a9_eb92_40a8_9f58_eaebf3bf6daf
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: O14975
is encoded by: hsa:11001
initial amount: NaN
is: SBO:0000252
name: SLC27A2
boundary condition: true

metaM CE1944 c
type: Species
name: 1-pyrrolinium
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:36781

metaR XOLTRIOLtm
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#
reversible: true
type: Reaction

metaR GLNSERNaEx
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
modifier: MODEL1310110049#
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM glyc c
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
boundary condition: false
is: HMDB00131
type: Species
constant: false
is: C00116
is: CHEBI:17754
name: Glycerol
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_c5168268_275f_46e5_8fea_670169264c94
initial concentration: NaN
name: _U37519_1_m
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:U37519
initial amount: NaN
is: SBO:0000252

metaR FAOXC2051843m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false
name: Beta oxidation of fatty acid
modifier: MODEL1310110049#
reversible: false

metaR HGNTOR
modifier: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.5
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)

metaR MI34PP
fast: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.66
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110049#
is: SBO:0000176
name: inositol-3,4-bisphosphate 4-phosphatase
reversible: false

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_0968d9d8_62ba_4368_8247_b0a55ca34c28
is encoded by: hsa:223
is: P49189
initial amount: NaN
has only substance units: false
name: ALDH9A1
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR GBSIDEte
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
name: globoside transport
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185

metaM nadph r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
constant: false
is: CHEBI:57783
is: C00005
is: HMDB00221
has only substance units: false
type: Species
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced

http://identifiers.org/biomodels.db/MODEL1310110049#_b48e21db_ebce_439c_881e_28cf51aa7b08
initial amount: NaN
type: Species
is encoded by: hsa:127
is: P08319
name: ADH4
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaR r0570
reversible: true
fast: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.3.3.2
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
kinetic law: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000

metaR PAPStg
is: SBO:0000185
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
name: 3'-Phosphoadenylyl sufate Golgi transport
kinetic law: MODEL1310110049#
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_dbc6eab6_197a_4a67_a856_8f1dfaef7e0d
has only substance units: false
initial concentration: NaN
name: PTDSS1
is: P48651
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9791
constant: false
boundary condition: true

metaR r1847
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
is: SBO:0000185

metaR RE1448N
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
name: RE1448
reactant: MODEL1310110049#
fast: false

metaM dsmsterol r
has only substance units: false
is: SBO:0000247
boundary condition: false
name: desmosterol
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
initial concentration: 1.0
constant: false
is: HMDB02719
is: CHEBI:17737
type: Species

metaM dgsn c
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species
constant: false
boundary condition: false
is: HMDB00085
has only substance units: false
is: SBO:0000247
is: CHEBI:17172
is: C00330
name: Deoxyguanosine
initial concentration: 1.0

metaR NADS2
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
name: NAD synthase (glutamine-hydrolysing)
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.1
is described by: ECO:0000269
modifier: MODEL1310110049#

metaR NADtpu
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: NAD transporter, peroxisome
type: Reaction
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
reversible: false

metaR DAG HSter
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: diacylglycerol ER export
type: Reaction
fast: false
product: MODEL1310110049#
is described by: ECO:0000000

metaM ksii core2 deg6 l
is: HMDB00143
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 6
notes: FORMULA: C44H72N4O33SX CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_82f32604_94c2_4019_8a22_6706fd4aee08
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:55350
name: VNN3
constant: false
is: SBO:0000252

metaR DHFR
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
modifier: MODEL1310110049#
name: dihydrofolate reductase
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110049#_a8ba85ef_b6d3_46fa_b8ed_2285917a5ec8
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
name: LDHAL6B
boundary condition: true
is: SBO:0000252
is encoded by: hsa:92483
is: Q9BYZ2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_16c07a55_ca83_4f6f_8956_cdd2db578fb0
initial concentration: NaN
type: Species
is: P51648
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ALDH3A2
is encoded by: hsa:224
boundary condition: true

metaR 5HOXINDACTO2OX
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.3.1
fast: false
modifier: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
is: SBO:0000176
product: MODEL1310110049#
type: Reaction
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
is described by: ECO:0000304
kinetic law: MODEL1310110049#

metaM 4mzym int1 r
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: 4-Methylzymosterol intermediate 1
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
has only substance units: false
is: HMDB06927
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_1d25ef21_2e7e_42e2_b4ea_24408d1869ac
constant: false
boundary condition: true
is encoded by: hsa:AI345944
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: _AI345944_1_m
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_e0f4ef14_d3ad_4a0d_a29b_aa8631363e0b
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110049#_6afd930f_1d4d_46c8_9f9c_99f6bf09748d
is: E7ET30
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:50808
name: AK3
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false

metaR r1841
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_b85ff26c_0941_4a29_ab7f_87dbf31e9413
type: Species
has only substance units: false
constant: false
is: P54868
is encoded by: hsa:3158
name: HMGCS2
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM ahcys c
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-Adenosyl-L-homocysteine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00939
type: Species
is: CHEBI:16680
constant: false
is: C00021
is: SBO:0000247
boundary condition: false

metaM dhor S c
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial amount: NaN
is: CHEBI:30864
name: (S)-dihydroorotate
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB03349
type: Species
has only substance units: false
is: SBO:0000247

metaR ALASm
reactant: MODEL1310110049#
is described by: ECO:0000254
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.37
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.29
name: 5-aminolevulinate synthase

http://identifiers.org/biomodels.db/MODEL1310110049#_f6aef5b8_5b16_421a_a85f_5b24d15f8a2c
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4720
initial concentration: NaN
is: B7Z792
initial amount: NaN
name: NDUFS2

metaM udpg r
boundary condition: false
is: HMDB00286
has only substance units: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species
is: CHEBI:58367
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate

metaR CERT1gt
product: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
is described by: ECO:0000304
reactant: MODEL1310110049#
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_7f60e2e8_3f75_4ded_b8d4_0a88e87fb7aa
type: Species
is encoded by: hsa:4726
name: NDUFS6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q6IBC4

http://identifiers.org/biomodels.db/MODEL1310110049#_6c652257_0d5e_4c50_82d7_97753ace5653
has only substance units: false
name: PDE10A
type: Species
initial concentration: NaN
is encoded by: hsa:10846
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9Y233

http://identifiers.org/biomodels.db/MODEL1310110049#_b8f028e8_cb7d_4d95_951b_146b7fa4413c
type: Species
is encoded by: hsa:2591
initial concentration: NaN
name: GALNT3
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q14435
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_97df5a5b_2565_4c3a_859f_56982ec362b6
type: Species
name: ST6GALNAC1
is: Q9NSC7
constant: false
initial amount: NaN
is encoded by: hsa:55808
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR ME1m
is: SBO:0000176
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.38
reactant: MODEL1310110049#
name: malic enzyme (NAD), mitochondrial
product: MODEL1310110049#

metaM nadph m
boundary condition: false
is: SBO:0000247
is: C00005
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
initial concentration: 1.0
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_06e23f67_1f6d_4453_ac65_bb24ac8e4dbf
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:100128062
name: _100128062_1_m
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR CORE6GTg
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
is described by: ECO:0000000

metaR RE1530C
is described by: ECO:0000000
product: MODEL1310110049#
reversible: true
is: SBO:0000176
reactant: MODEL1310110049#
fast: false
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
kinetic law: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_9254fda9_d1ac_465b_bad0_276e818e2183
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:206358
is: Q1LZ56
constant: false
initial amount: NaN
boundary condition: true
name: SLC36A1

metaM ksi pre28 g
has only substance units: false
is: CHEBI:58053
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 28
initial amount: NaN
is: C00130
type: Species
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110049#_97656732_591c_436c_aa66_b5aca548eb83
name: NDUFA3
type: Species
is encoded by: hsa:4696
is: O95167
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_0fbc12fc_5e3b_48c9_ae11_c8d81535c8de
is: P06744
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:2821
type: Species
boundary condition: true
name: GPI
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_7ced69c1_2956_435f_8852_261faff1d6b2
is: SBO:0000252
name: NDUFA9
boundary condition: true
initial amount: NaN
is: Q16795
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4704
constant: false
type: Species

metaM coa m
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
is: SBO:0000247
name: Coenzyme A
type: Species
is: HMDB01423
has only substance units: false
is: C00010

metaM apoC m
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:32551
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
is: HMDB00182
name: Apocarboxlase (no lys residue)
is: SBO:0000247
constant: false

metaR r0033
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
kinetic law: MODEL1310110049#

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM glyald m
type: Species
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
name: D-glyceraldehyde
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01051
is: CHEBI:17378
constant: false

metaR S6TASE4ly
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
product: MODEL1310110049#
name: N-acetylgalactosamine-6-sulfatase, lysosomal

metaR r0720
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
type: Reaction
product: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_af05411d_2476_4d7e_a16b_9f13820df2df
is: SBO:0000252
is: P47895
constant: false
name: ALDH1A3
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:220

metaM 4mlacac c
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17105
name: 4-maleylacetoacetate
has only substance units: false
constant: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: HMDB02052
is: SBO:0000247
initial amount: NaN

metaM 4abut m
is: CHEBI:16865
boundary condition: false
name: 4-Aminobutanoate
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00334
is: HMDB00112
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334

metaM HC01405 m
type: Species
constant: false
name: (S)-Hydroxyoctanoyl-CoA
initial amount: NaN
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:28632

metaR PROSTGE1t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
fast: false
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
is described by: ECO:0000269
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#

metaR DGAT
name: diacylglycerol acyltransferase
reversible: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.20
is: SBO:0000176
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
product: MODEL1310110049#

metaM m2emgacpail hs r
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: http://identifiers.org/pubchem.compound/3380
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:24636
is: C00080
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM ditp n
has only substance units: false
initial amount: NaN
is: CHEBI:61382
name: dITP(4-)
is: HMDB03537
constant: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM coa n
is: HMDB01423
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57287
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR B3GNT311g
kinetic law: MODEL1310110049#
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000254
reactant: MODEL1310110049#

metaM sarcs c
initial amount: NaN
is: SBO:0000247
name: Sarcosine
constant: false
is: HMDB00271
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0
is: CHEBI:3513
is: C00213
type: Species
boundary condition: false
has only substance units: false

metaR DNDPt38m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
name: dUTP transport via dUDP antiport
modifier: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
reactant: MODEL1310110049#
type: Reaction

metaR NDPK8n
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110049#
is described by: ECO:0000304
type: Reaction
fast: false

metaR GBSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
is: SBO:0000185
fast: false
name: globoside intracellular transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_8a1e4eb6_654c_4898_b3d5_777298d5d87a
type: Species
has only substance units: false
boundary condition: true
name: GBA
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:2629
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_8818ad4e_58d4_4618_826e_a0e920e25726
constant: false
has only substance units: false
type: Species
name: ACLY
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:47
initial amount: NaN

metaR ASCBt4
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: L-ascorbate transport via proton symport
product: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_b8a5414c_07ea_4568_b3ae_019cea590683
type: Species
is: SBO:0000252
has only substance units: false
name: NDUFA11
is encoded by: hsa:126328
initial concentration: NaN
is: C9JT23
constant: false
initial amount: NaN
boundary condition: true

metaR GALASE1ly
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
name: beta-galactosidase, lysosomal
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR r0722
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.3.12
reversible: true
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110049#
modifier: MODEL1310110049#

metaM o2 x
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
is: HMDB01377
boundary condition: false
is: CHEBI:15379
initial concentration: 1.0
name: O2
has only substance units: false
is: SBO:0000247
type: Species
is: C00007

metaR r1851
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110049#

metaM ala B m
type: Species
is: CHEBI:16958
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
name: beta-alanine
is: HMDB00056
is: SBO:0000247

metaR DNDPt18m
type: Reaction
is: SBO:0000185
name: dUDP transport via ADP antiport
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110049#

metaM 2dr5p c
is: CHEBI:57651
constant: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: HMDB01031
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r0723
reversible: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
type: Reaction
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_ff5d4563_c300_40c2_ab33_af431d4ba44d
is encoded by: hsa:224
constant: false
initial amount: NaN
name: ALDH3A2
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P51648
has only substance units: false

metaR METtec
name: L-methionine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110049#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110049#
modifier: MODEL1310110049#

metaM CE4792 m
initial concentration: 1.0
is: HMDB00127
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: CHEBI:15748
name: 3-oxo-cis-8-tetradecenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110049#_848a7688_3eed_4bae_ba40_ce0d35bfbcd1
initial amount: NaN
is encoded by: hsa:196883
has only substance units: false
is: SBO:0000252
name: ADCY4
constant: false
initial concentration: NaN
boundary condition: true
is: Q8NFM4
type: Species

metaR MTHFR3
is: SBO:0000176
product: MODEL1310110049#
type: Reaction
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
is version of: http://identifiers.org/ec-code/1.5.1.20
modifier: MODEL1310110049#
reversible: false
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
kinetic law: MODEL1310110049#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110049#_3d376bd1_8918_4242_8c4c_6489a23acfae
initial amount: NaN
name: QPRT
constant: false
is: Q15274
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:23475

http://identifiers.org/biomodels.db/MODEL1310110049#_99b479e2_4639_4519_9aa4_70c7b483a943
initial concentration: NaN
is encoded by: hsa:1716
type: Species
has only substance units: false
constant: false
name: DGUOK
is: SBO:0000252
is: E5KSL6
initial amount: NaN
boundary condition: true

metaM CE5162 r
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
is: SBO:0000247
constant: false
initial concentration: 1.0
name: trans,cis-2,9-octadecadienoyl-CoA
boundary condition: false
has only substance units: false
is: CHEBI:15748
is: HMDB00127
initial amount: NaN

metaR CYSGLTH
name: Glutathione:cystine oxidoreductase
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
kinetic law: MODEL1310110049#

metaM galthcrm hs g
is: SBO:0000247
has only substance units: false
type: Species
name: Gal-Gal-Gal-Glc-Cer
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0
is: CHEBI:26174

http://identifiers.org/biomodels.db/MODEL1310110049#_6697abae_fdda_41a7_9c10_0003cb46f876
is: Q9UHV8
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:29124
name: LGALS13
initial concentration: NaN
boundary condition: true
type: Species

metaM dlnlcgcoa c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27979
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false
boundary condition: false
has only substance units: false
type: Species

metaM xoltriol c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB01457
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
has only substance units: false
is: SBO:0000247
is: CHEBI:16496
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol

metaR r2329
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
product: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110049#

metaR r2328
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110049#
fast: false
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_d9223567_c40a_4070_b32f_0f2ab6a63db5
has only substance units: false
type: Species
name: ACSS2
initial amount: NaN
initial concentration: NaN
is: Q5QPH3
is: SBO:0000252
is encoded by: hsa:55902
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_0df74c95_6488_4078_8adb_c75211ec6b0e
is encoded by: hsa:5634
is: P11908
constant: false
initial concentration: NaN
name: PRPS2
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_4996c8a3_4ad0_4f6c_af10_470f25a3b7e3
constant: false
initial amount: NaN
boundary condition: true
is: B1AM93
initial concentration: NaN
name: NDUFA8
type: Species
is encoded by: hsa:4702
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_b96f7b6a_ee21_4ecf_819a_39543737132c
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: P59796
is: SBO:0000252
has only substance units: false
is encoded by: hsa:257202
name: GPX6

metaM clpn hs c
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
is: HMDB00156
initial amount: NaN
is: CHEBI:15589
name: clpn_hs[c]

http://identifiers.org/biomodels.db/MODEL1310110049#_cbfb987f_c631_4eeb_89e6_d63f2377fabd
has only substance units: false
name: PMVK
initial amount: NaN
is encoded by: hsa:10654
boundary condition: true
is: SBO:0000252
constant: false
is: Q6FGV9
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_7daa045b_de4c_4a2a_a179_b89229f196af
is encoded by: hsa:56623
initial concentration: NaN
is: Q9NRR6
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: INPP5E

metaR GALASE19ly
modifier: MODEL1310110049#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM btcoa m
constant: false
initial concentration: 1.0
name: Butanoyl-CoA
is: SBO:0000247
is: HMDB01088
is: C00136
initial amount: NaN
type: Species
is: CHEBI:57371
has only substance units: false
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136

metaM glyc e
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
is: C00116
is: HMDB00131
type: Species
name: Glycerol
is: SBO:0000247
constant: false

metaM T antigen g
initial amount: NaN
type: Species
initial concentration: 1.0
name: T antigen (core 1)
has only substance units: false
is: SBO:0000247
is: CHEBI:22783
constant: false
notes: FORMULA: C14H24NO10X CHARGE: 0
boundary condition: false

metaM nadph c
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
constant: false
is: CHEBI:57783
has only substance units: false

metaM lnlncg r
boundary condition: false
initial amount: NaN
name: gamma-linolenate
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
is: SBO:0000247
is: CHEBI:32391
has only substance units: false

metaM fadh2 x
type: Species
is: CHEBI:58307
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
initial amount: NaN
constant: false
name: FADH2(2-)
initial concentration: 1.0

metaR DOLPMT2 Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reversible: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_2077dbeb_6e75_4937_b397_775b01ec9239
initial amount: NaN
constant: false
is: SBO:0000252
is: P23921
has only substance units: false
type: Species
name: RRM1
is encoded by: hsa:6240
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_d49839dc_672d_4558_9f5e_858979ad0aa8
constant: false
is encoded by: hsa:51227
is: SBO:0000297
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR UGLCNACtg
reversible: true
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
name: UDP-GlcNAc Golgi transport via CMP antiport
product: MODEL1310110049#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000269
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

metaR 3DSPHR
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
name: 3-Dehydrosphinganine reductase
is: SBO:0000176
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.102
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_69562c59_b0d4_4d31_a349_ac49033cceaf
name: NDUFV3
is: SBO:0000252
initial amount: NaN
type: Species
is: P56181
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4731

metaM o2 r
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01377
is: SBO:0000247
is: CHEBI:15379
is: C00007
name: O2
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR INSK
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: false
type: Reaction
name: insosine kinase
reactant: MODEL1310110049#

metaR ACACT5p
type: Reaction
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110049#

metaR RE3050R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reversible: true
product: MODEL1310110049#
name: RE3050
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR FAOXC16DCr
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR RE2659R
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
name: RE2659
reversible: true
is: SBO:0000176

metaM dkmpp c
name: 2,3-diketo-5-methylthio-1-phosphopentane
is: C15650
notes: FORMULA: C6H9O6PS CHARGE: -2
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:58828
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaR r2325
kinetic law: MODEL1310110049#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110049#

metaM betald c
is: CHEBI:15710
is: SBO:0000247
is: HMDB01252
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
type: Species
constant: false
name: betaine aldehyde
initial amount: NaN

metaR r0728
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110049#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110049#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110049#

metaR PAIL45P HStn
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110049#
type: Reaction
fast: false
product: MODEL1310110049#

metaR S2L2N2M2MASNtly
fast: false
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: s2l2n2m2masn transport, extracellular to lysosome
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_eb6348b6_042d_4b0b_a267_a76cbabb60b0
has only substance units: false
is: Q75T13
name: PGAP1
initial amount: NaN
is encoded by: hsa:80055
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR SO4CLtex2
fast: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: sulfate transport via chloride countertransport (2:1)
reactant: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110049#
reversible: false
product: MODEL1310110049#
type: Reaction

metaM ptdca c
has only substance units: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/22169126
is: SBO:0000247
constant: false
is: HMDB00826
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
name: pentadecanoate

metaM lnlncg l
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial amount: NaN
name: gamma-linolenate
type: Species
constant: false
has only substance units: false
is: CHEBI:32391
is: SBO:0000247
is: HMDB03073

metaM succoa m
is: HMDB01022
name: Succinyl-CoA
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57292
constant: false
initial concentration: 1.0
initial amount: NaN

metaM sphmyln hs c
name: sphmyln_hs[c]
is: SBO:0000247
is: CHEBI:15589
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00156
type: Species
has only substance units: false
notes: FORMULA: CHARGE: 0

metaM 5mta c
name: 5-Methylthioadenosine
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: C00170
initial amount: NaN
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: CHEBI:17509
is: SBO:0000247
is: HMDB01173

metaR r2324
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110049#
type: Reaction

metaM ksi deg26 l
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00061
name: keratan sulfate I, degradation product 26
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: CHEBI:58343
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_1a0390f8_2920_497b_931c_6693f6d5cbd2
initial amount: NaN
name: ATP5E
initial concentration: NaN
is encoded by: hsa:514
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_442e7329_7a11_41f8_96dc_61b6a33af61b
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ST3GAL3
constant: false
is encoded by: hsa:6487

http://identifiers.org/biomodels.db/MODEL1310110049#_85b6e88b_2e6e_449e_8da2_6e36acfb698c
initial amount: NaN
is: Q53Y25
constant: false
has only substance units: false
is encoded by: hsa:2645
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GCK
type: Species

metaM coa g
is: HMDB01423
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:57287
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_f9d72ec7_4464_4420_bfb2_082f37d2e1b1
initial concentration: NaN
is encoded by: hsa:2584
boundary condition: true
has only substance units: false
type: Species
constant: false
name: GALK1
is: SBO:0000252
is: P51570
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_d2dba320_c737_41bb_940a_acc3418c8729
boundary condition: true
name: DGKH
is: SBO:0000252
is: Q86XP1
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:160851
has only substance units: false

metaR GGH 10FTHF5GLUe
fast: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176

metaR NH4t3r
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000185
name: ammonia transport via proton antiport
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
product: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000269

metaR GLCNACT L
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110049#
is: SBO:0000176
fast: false
reversible: false

metaM didp n
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: HMDB03536
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28823
name: dIDP

metaM apoC c
is: HMDB11111
has only substance units: false
constant: false
name: Apocarboxlase (no lys residue)
type: Species
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: CHEBI:33190
is: SBO:0000247
initial amount: NaN

metaR GARFT
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
name: phosphoribosylglycinamide formyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.2
fast: false
reversible: true
kinetic law: MODEL1310110049#

metaM udpg c
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false
has only substance units: false
type: Species
is: C00029
is: HMDB00286
is: CHEBI:58367
name: UDPglucose
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_9c39bf8e_6f11_43ab_baf2_5c0cbcd4d9e4
initial concentration: NaN
has only substance units: false
name: FUT1
is: SBO:0000252
initial amount: NaN
constant: false
is: Q6IZA2
is encoded by: hsa:2523
type: Species
boundary condition: true

metaR r2327
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110049#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR r2101
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false

metaR CREATt4 2 r
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: Creatine transport (sodium symport) (2:1)
reversible: true
reactant: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
fast: false

metaM sarcs m
is: CHEBI:15611
name: Sarcosine
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: C00213
is: HMDB00271
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110049#
type: Reaction
name: sialidase, lysosomal
product: MODEL1310110049#
is described by: ECO:0000000

metaR RBTt
name: ribitol transport via passive diffusion
fast: false
product: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
reversible: false
is described by: ECO:0000000

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_e285cacd_cf5a_4195_93c1_e4690d87e425
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _H45672_1_m
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:H45672

metaM HC02204 e
initial concentration: 1.0
constant: false
initial amount: NaN
name: prostaglandin-b1
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaM HC01408 m
constant: false
name: 3-Oxohexanoyl-CoA
type: Species
is: CHEBI:27648
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_88498ecc_fe81_4976_90e0_06f68624256c
has only substance units: false
boundary condition: true
type: Species
is: O14495
constant: false
initial concentration: NaN
initial amount: NaN
name: PPAP2B
is: SBO:0000252
is encoded by: hsa:8613

metaR FAOXC12DCTc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_57cdd80e_880a_40a0_af94_cc1192ab09b1
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:10380
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: BPNT1
type: Species
is: O95861

metaR r2100
is: SBO:0000185
modifier: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: CHEBI:32814
constant: false
initial amount: NaN
is: C00438
name: N-Carbamoyl-L-aspartate
boundary condition: false
is: HMDB00828
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaR r0149
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#

metaR ACGAMtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
product: MODEL1310110049#
is: SBO:0000185
type: Reaction
name: N-acetyl-glucosamine lysosomal efflux
kinetic law: MODEL1310110049#
reversible: false
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000

metaR FUT18g
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.69
modifier: MODEL1310110049#
name: Galactoside 2-alpha-L-fucosyltransferase 1
is described by: ECO:0000269
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is: SBO:0000176

metaM damp c
is: CHEBI:58245
constant: false
boundary condition: false
name: dAMP(2-)
initial concentration: 1.0
is: HMDB00905
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: SBO:0000247

metaM 5mta e
name: 5-Methylthioadenosine
initial concentration: 1.0
initial amount: NaN
is: C00170
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: CHEBI:17509
constant: false
type: Species
is: HMDB01173
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_54d82805_38d8_406a_8cf2_ef093dd66cc4
constant: false
initial concentration: NaN
is encoded by: hsa:491
is: SBO:0000252
has only substance units: false
type: Species
name: ATP2B2
boundary condition: true
initial amount: NaN
is: Q4J699

metaM ala B e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
name: beta-alanine
boundary condition: false
type: Species
is: HMDB00056
initial concentration: 1.0
is: CHEBI:16958
constant: false
is: SBO:0000247
initial amount: NaN

metaM accoa x
type: Species
boundary condition: false
initial amount: NaN
is: C00024
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
initial concentration: 1.0
name: Acetyl-CoA
is: HMDB01206
constant: false

metaR r2326
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: true

metaR ABO7g
is: SBO:0000176
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reactant: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
modifier: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.37
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_33c2f5ec_5c82_48f3_9ac1_250ae0deaca4
name: BDH1
is encoded by: hsa:622
type: Species
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM o2 m
boundary condition: false
has only substance units: false
name: O2
is: C00007
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:15379

metaR r2321
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaR r0724
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110049#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110049#
fast: false
is: SBO:0000176

metaM thr L e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00167
is: SBO:0000247
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
constant: false
name: L-threonine
type: Species
has only substance units: false

metaR r0142
fast: false
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reversible: false
modifier: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110049#
name: beta-galactosidase, lysosomal
modifier: MODEL1310110049#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_207c1c53_c1dc_431d_b3a4_5ebbc668b68b
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC6A9
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6536
is: B7Z3W8
type: Species

metaR G3PD1
type: Reaction
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
is described by: ECO:0000269
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: true
name: glycerol-3-phosphate dehydrogenase (NAD)

metaR G14T13g
reactant: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_21f8db8f_4366_4ce7_a86d_d3832fab813a
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q08M29
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:2651
name: GCNT2

metaR PVD3
reactant: MODEL1310110049#
is described by: ECO:0000134
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000176
fast: false
name: Previtamin D3 formation
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT

metaM o2 n
name: dioxygen
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01377
has only substance units: false

metaR DM ethamp r
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_f46d8f50_8d0e_4662_8740_3877dc0339ca
name: BTD
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:686
initial concentration: NaN
is: P43251
type: Species
constant: false

metaR r2320
is: SBO:0000185
fast: false
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM cbasp e
is: CHEBI:32814
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: N-Carbamoyl-L-aspartate
is: C00438
type: Species
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: HMDB00828
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_029be024_4190_4542_bb73_006d0a99bbb2
constant: false
type: Species
has only substance units: false
name: SLC33A1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9197
boundary condition: true
is: O00400

metaR GLCtg
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
kinetic law: MODEL1310110049#
is: SBO:0000185
reversible: true
name: glucose transport, Golgi apparatus
fast: false
type: Reaction
modifier: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#
reactant: MODEL1310110049#

metaM coa c
name: Coenzyme A
constant: false
is: CHEBI:3312
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: C00010
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM dmpp x
constant: false
name: prenyl diphosphate(3-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01120
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: CHEBI:57623
has only substance units: false

metaM glyc m
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
is: HMDB00131
type: Species
boundary condition: false
is: CHEBI:17754
is: C00116
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r0726
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110049#
modifier: MODEL1310110049#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR r2323
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_903217a0_85cd_44ce_9024_79503119a1e0
initial amount: NaN
is: SBO:0000252
type: Species
name: GALNT10
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:55568
has only substance units: false

metaR LPS3
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.1.23
fast: false
reactant: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
name: lipase
is: SBO:0000176

metaR DOLPMT4 Ler
reversible: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
kinetic law: MODEL1310110049#

metaR SO4HCOtex
fast: false
modifier: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000304
name: sulfate transport via bicarbonate countertransport
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
reversible: false

metaM thr L c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
is: CHEBI:16857
name: L-threonine
is: SBO:0000247
constant: false
has only substance units: false
type: Species

metaR CYTK8n
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110049#
name: cytidylate kinase (CMP,dATP),nuclear
kinetic law: MODEL1310110049#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110049#
is described by: ECO:0000269

metaR GBA
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.45
kinetic law: MODEL1310110049#
name: Glucosylceramidase
is described by: ECO:0000000
product: MODEL1310110049#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_9c83189d_d5ba_48c2_8f00_46bdc76db6e1
has only substance units: false
boundary condition: true
name: FBP1
is: Q2TU34
type: Species
is encoded by: hsa:2203
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_884e718d_2c22_4d6c_a433_afa46b9eb18d
type: Species
is: Q8IXK2
boundary condition: true
initial concentration: NaN
name: GALNT12
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:79695
initial amount: NaN

metaR r2322
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaR r0145
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.8.3.1
modifier: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39

metaR ABTD
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
name: L-arabinitol 4-dehydrogenase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_40d53915_ea8a_4e4f_ace6_9b976e8b498d
name: ATP5D
is: P30049
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:513

http://identifiers.org/biomodels.db/MODEL1310110049#_a6dfcf11_c0de_4b21_8dff_238bc29dd539
is encoded by: hsa:7296
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: TXNRD1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
initial concentration: 1.0
is: CHEBI:61648
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

metaM ptdca e
is: http://identifiers.org/pubchem.compound/22169126
type: Species
boundary condition: false
name: pentadecanoate
is: HMDB00826
has only substance units: false
constant: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r2027
is described by: ECO:0000000
modifier: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM sbt D c
name: D-glucitol
boundary condition: false
constant: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247
is: CHEBI:17924
initial amount: NaN
has only substance units: false
is: HMDB00247
type: Species
initial concentration: 1.0

metaM leuktrC4 c
type: Species
name: leukotriene C4(2-)
is: CHEBI:57973
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
constant: false
is: HMDB01198
is: SBO:0000247
has only substance units: false

metaR DOLGPP Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_f0388a61_f34b_44bc_8835_f74fcdc8918d
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:1103
initial concentration: NaN
is: Q6LEN5
has only substance units: false
constant: false
name: CHAT
boundary condition: true

metaR RE1836X
name: RE1836
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
type: Reaction
is: SBO:0000176
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#

metaM ksi pre13 g
name: keratan sulfate I biosynthesis, precursor 13
constant: false
is: SBO:0000247
boundary condition: false
is: C00130
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00175

metaR PMANM
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.8
is version of: http://identifiers.org/ec-code/5.4.2.2
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110049#
is: SBO:0000176
name: phosphomannomutase

http://identifiers.org/biomodels.db/MODEL1310110049#_1bc368bb_6225_4255_8e59_3742b07c8d77
is: SBO:0000252
type: Species
constant: false
name: SLC16A1
is: B4DKS0
initial amount: NaN
is encoded by: hsa:6566
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR LEUKTRE4t
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: leukotriene E4 transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110049#

metaR AG13T14g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_c5a62787_0578_47e8_9a9b_44cffecbc9b2
type: Species
name: NSF
is: P46459
is encoded by: hsa:4905
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR RE3006M
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110049#
name: RE3006
product: MODEL1310110049#
modifier: MODEL1310110049#

metaM ach c
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
name: acetylcholine
is: CHEBI:15355
is: HMDB00895
has only substance units: false
is: SBO:0000247
constant: false

metaM xoltriol m
has only substance units: false
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: CHEBI:16496
type: Species
constant: false
initial amount: NaN
is: HMDB01457

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR NADPHtxu
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
is: SBO:0000185
name: NADPH transporter, peroxisome
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#

metaR r1164
kinetic law: MODEL1310110049#
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
name: EC:2.3.1.26
is: SBO:0000176
reactant: MODEL1310110049#

metaR SERDGLYexR
reactant: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
type: Reaction
is: SBO:0000185
name: D-Serine/Glycine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110049#_82e6363b_a54b_47cc_bfad_453585ab00a1
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1716
name: DGUOK
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: E5KSL5

metaM pail5p hs n
is: CHEBI:57795
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR GTHDH
kinetic law: MODEL1310110049#
is described by: ECO:0000134
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110049#
type: Reaction

metaM na1 c
has only substance units: false
is: CHEBI:4541
type: Species
boundary condition: false
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
is: C01330
name: Sodium
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaR r0973
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: Facilitated diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_99261915_28c0_40a0_a0b2_e459ad86cb6a
boundary condition: true
has only substance units: false
is encoded by: hsa:51
is: B4DK61
is: SBO:0000252
type: Species
initial amount: NaN
name: ACOX1
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_dc99b1a4_8cde_43b8_aad5_7e8d084d5163
is encoded by: hsa:728226
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: _728226_1_m
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_73888e82_9943_4f64_a9c5_7c27b9ed0bc2
is: SBO:0000252
name: GBA
is: P04062
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2629
has only substance units: false
type: Species

metaR SUBERCACT
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR ACGALtly
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
name: N-acetyl-galactosamine lysosomal efflux
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_53675708_3cab_444e_81ae_579938117033
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1350
is: SBO:0000252
name: COX7C
boundary condition: true
is: P15954
type: Species
constant: false

metaM CE2418 m
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: SBO:0000247
constant: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:28387
is: HMDB11123
has only substance units: false
type: Species

metaM chito2pdol U c
has only substance units: false
is: CHEBI:12427
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_94c78197_4fa0_4c6d_b1b4_1424630288ce
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P05091
constant: false
is encoded by: hsa:217
type: Species
is: SBO:0000252
has only substance units: false
name: ALDH2

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_1ea054e4_2489_4318_9434_991c2a1fa729
boundary condition: true
is: B3KXN9
initial concentration: NaN
is: SBO:0000252
name: ADO
is encoded by: hsa:84890
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR DESAT22 2p
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
reactant: MODEL1310110049#
type: Reaction

metaR DGSNtm
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
is: SBO:0000185
reactant: MODEL1310110049#
fast: false
name: deoyguanosine transport in mitochondria
type: Reaction
is described by: ECO:0000000
reversible: true

metaM leuktrC4 e
is: SBO:0000247
is: HMDB01198
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
has only substance units: false
is: CHEBI:57973
boundary condition: false
initial concentration: 1.0
constant: false
name: leukotriene C4(2-)

metaM pi x
type: Species
is: CHEBI:43474
constant: false
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
is: HMDB00973
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110049#_8397c4c5_b5c6_46fc_a5c1_da1c5bd7e224
is encoded by: hsa:33
initial concentration: NaN
name: ACADL
is: P28330
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM ach e
is: SBO:0000247
constant: false
is: CHEBI:15355
initial concentration: 1.0
name: acetylcholine
initial amount: NaN
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
boundary condition: false
type: Species

metaR NACHEXA18ly
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false

metaR r0410
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reversible: true
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_12728dcf_8e71_4253_8800_0868501206a4
is encoded by: hsa:6487
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ST3GAL3
boundary condition: true
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_c989f782_b774_4d73_82d1_5eddd21ab3da
type: Species
is: P15328
constant: false
is encoded by: hsa:2348
name: FOLR1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM ocdcea e
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00207
initial concentration: 1.0
is: CHEBI:0
name: octadecenoate (n-C18:1)
boundary condition: false
is: C00712
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1

metaR TCHOLAtx
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110049#
name: bile acid intracellular transport

metaM icit m
is: HMDB00193
name: Isocitrate
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00311
type: Species
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaM 3mgcoa m
initial amount: NaN
is: HMDB01057
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: trans-3-methylglutaconyl-CoA(5-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57346
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231

http://identifiers.org/biomodels.db/MODEL1310110049#_96d66110_3d13_4dd5_b5e5_81707c1d2e64
initial amount: NaN
name: LIPC
is: A6H8L5
is encoded by: hsa:3990
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_4533ea58_2a52_4c08_a5ec_e444931f74c7
name: NDUFB10
has only substance units: false
is encoded by: hsa:4716
boundary condition: true
is: A8K761
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM sbt D e
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: HMDB00247
name: D-glucitol
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR r0560
reversible: false
type: Reaction
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
is: SBO:0000176
product: MODEL1310110049#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
kinetic law: MODEL1310110049#

metaM ksi deg15 l
initial amount: NaN
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 15
boundary condition: false
is: HMDB00143
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:12936

metaM HC02210 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: prostaglandin-d3
has only substance units: false
is: SBO:0000247
is: CHEBI:34939

http://identifiers.org/biomodels.db/MODEL1310110049#_4e0fd338_473d_403f_8096_0e08ea81c01e
constant: false
boundary condition: true
is encoded by: hsa:6817
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SULT1A1
type: Species

metaR r2371
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185

metaR GMPtg
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
reversible: true
name: GMP transport (Golgi)
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
type: Reaction

metaR TMDK1
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.21
reversible: false
name: thymidine kinase (ATP:thymidine)
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_41cc4697_bf33_4f26_8531_b0f7cab09feb
is encoded by: hsa:4726
initial amount: NaN
constant: false
is: Q6IBC4
name: NDUFS6
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR RE2626M
is described by: ECO:0000000
name: RE2626
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110049#
type: Reaction

metaR FAOXC16080m
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_091ecaa3_d4cb_48f5_b93f_59cccb8cb044
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: _R51273_1_c
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:R51273

metaM 3pg c
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58272
is: http://identifiers.org/pubchem.compound/3497
type: Species
initial amount: NaN
has only substance units: false
is: C00197
is: SBO:0000247
name: 3-Phospho-D-glycerate
is: HMDB00807

metaR DOLPH Uer
product: MODEL1310110049#
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000

metaR FATP3t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
name: fatty acid electroneutral transport
fast: false
reactant: MODEL1310110049#
reversible: true
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_76af0131_bc4a_4108_bdc1_6db3199b9071
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA081045
name: _AA081045_1_m
initial concentration: NaN

metaM 3mox4hoxm c
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 3-Methoxy-4-hydroxymandelate
is: CHEBI:27622
initial amount: NaN
type: Species
is: HMDB00291
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_df311dea_22db_4622_86b6_3caa9626365b
is: SBO:0000252
boundary condition: true
name: DYLX2
is encoded by: hsa:9856
constant: false
type: Species
initial amount: NaN
is: F5H123
has only substance units: false
initial concentration: NaN

metaM cholcoa x
boundary condition: false
has only substance units: false
is: HMDB01374
constant: false
is: CHEBI:57373
initial amount: NaN
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: SBO:0000247
initial concentration: 1.0
type: Species
name: choloyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110049#_55d1f130_d67f_401e_86f3_544f6fe3f6f8
is: SBO:0000252
is encoded by: hsa:7359
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: _7359_1_c

metaM 4pyrdx c
is: HMDB00017
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
boundary condition: false
constant: false
is: CHEBI:30959
is: SBO:0000247
initial amount: NaN
name: 4-pyridoxate
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_4527fbf2_6cbf_4b47_9ccc_0ade91fa5d23
is encoded by: hsa:57786
boundary condition: true
name: RBAK
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9NYW8

metaR RIBt
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: true
fast: false
name: ribose transport via diffusion
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110049#

metaM cholcoaone x
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB06891
type: Species
is: CHEBI:58507
constant: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM xu5p D c
boundary condition: false
is: CHEBI:57737
has only substance units: false
constant: false
initial amount: NaN
name: D-xylulose 5-phosphate(2-)
type: Species
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial concentration: 1.0
is: HMDB00868

metaM s2l2n2m2m l
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C84H136N6O62 CHARGE: -2
initial concentration: 1.0
name: de-Fuc form of PA6 (w/o peptide linkage)
is: CHEBI:57312
is: HMDB01356

metaR MGCHrm
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110049#
type: Reaction
fast: false
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
reversible: true
product: MODEL1310110049#

metaR r1167
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
name: EC:2.3.1.26
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is: SBO:0000176
reactant: MODEL1310110049#
reversible: false
fast: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR r0974
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is: SBO:0000185
name: Active transport
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
fast: false
reactant: MODEL1310110049#
reversible: true

metaM 1p3h5c m
is: CHEBI:6151
is: SBO:0000247
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: HMDB01369
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_d348f114_2be8_4cb0_8ace_87aa7c553b60
is: Q9ULC5
has only substance units: false
constant: false
is encoded by: hsa:51703
is: SBO:0000252
type: Species
name: ACSL5
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM na1 e
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
initial amount: NaN
name: Sodium
is: HMDB00588
has only substance units: false
is: CHEBI:4541
is: C01330
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_34e863da_e1d2_4d06_8004_0d98642a6158
has part: O75947
is encoded by: hsa:518
initial amount: NaN
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:515
has only substance units: false
has part: P24539
type: Species
boundary condition: true
is encoded by: hsa:10476
has part: P18859

http://identifiers.org/biomodels.db/MODEL1310110049#_479bf22c_b6b4_4a86_bd31_60372fc70700
is encoded by: hsa:427
initial amount: NaN
type: Species
has only substance units: false
name: ASAH1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q13510
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_fd04ad45_b6ef_4681_a70d_9ed4c9961f72
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: _AI291895_1_c
is: SBO:0000252
is encoded by: hsa:AI291895

http://identifiers.org/biomodels.db/MODEL1310110049#_9f79dbe9_fe56_4907_b3bf_56255eab00ee
initial concentration: NaN
has only substance units: false
is: Q5MY95
name: ENTPD8
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:377841
constant: false
is: SBO:0000252

metaR RE0691C
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: RE0691
reversible: true
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction

metaR r0653
kinetic law: MODEL1310110049#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
reversible: false

metaM zym int2 r
name: zymosterol intermediate 2
has only substance units: false
is: CHEBI:52386
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110049#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
reversible: false
type: Reaction
modifier: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM 1p3h5c c
is: HMDB01369
type: Species
is: CHEBI:6151
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial amount: NaN
initial concentration: 1.0
constant: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
boundary condition: false

metaM pi r
boundary condition: false
is: C00009
initial concentration: 1.0
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
initial amount: NaN
is: HMDB00973
name: hydrogenphosphate
is: SBO:0000247
type: Species
constant: false

metaR r2375
is: SBO:0000185
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
type: Reaction
fast: false
product: MODEL1310110049#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9a9583fd_1f5f_4b5d_ab47_4ead2383dbfc
boundary condition: true
constant: false
is encoded by: hsa:2643
type: Species
is: SBO:0000252
is: Q8IZH9
initial concentration: NaN
initial amount: NaN
name: GCH1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_90baa9bb_a56b_423e_887e_f7aa3a4b54aa
is encoded by: hsa:8813
initial concentration: NaN
is: O60762
initial amount: NaN
has only substance units: false
type: Species
name: DPM1
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_7deb76f1_5c34_4edb_ab7f_2bde38b19d3e
initial amount: NaN
has only substance units: false
is encoded by: hsa:89874
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: G3V4L5
initial concentration: NaN
name: SLC25A21

metaR BHBt
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: (R)-3-Hydroxybutanoate transport via H+ symport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
type: Reaction
reactant: MODEL1310110049#
fast: false

metaR C6COAt
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaM ksi pre27 g
is: HMDB00175
is: C00130
is: CHEBI:58053
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 27
initial concentration: 1.0

metaR GASNASE2ly
type: Reaction
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_f6528af1_1bf5_4a31_954e_d9c3a18b7c6f
is: P49441
is encoded by: hsa:3628
initial concentration: NaN
constant: false
is: SBO:0000252
name: INPP1
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaM q10h2 e
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB13111
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
initial amount: NaN
name: Ubiquinol-10

http://identifiers.org/biomodels.db/MODEL1310110049#_43090101_1e7e_4ef8_92ee_be1aa3c5da60
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: Q02127
initial concentration: NaN
is encoded by: hsa:1723
name: DHODH
constant: false

metaR r2374
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_27d0af95_1ef6_4f8c_9a46_f0a627df58ba
initial concentration: NaN
type: Species
is encoded by: hsa:4724
is: O43181
boundary condition: true
is: SBO:0000252
name: NDUFS4
constant: false
has only substance units: false
initial amount: NaN

metaR PMEVKc
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.2
name: phosphomevalonate kinase, cytosol
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
reversible: false
reactant: MODEL1310110049#
is: SBO:0000176

metaR r0651
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false

metaM amp x
has only substance units: false
is: HMDB00045
type: Species
is: CHEBI:456215
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
is: C00020
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_728585be_f882_4f23_9cef_353a655f974c
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: Q59HH3
initial concentration: NaN
is encoded by: hsa:2618
name: GART

metaR DGCHOLte
name: bile acid intracellular transport
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_78c2b28a_4d67_43b1_92a8_24d9f4960e74
boundary condition: true
is encoded by: hsa:5232
initial concentration: NaN
constant: false
name: PGK2
initial amount: NaN
is: P07205
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_77bf8062_9d25_4cb0_ad89_b0c14fbcc722
has only substance units: false
name: SLC22A3
is: Q5SYN6
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6581

metaR r2373
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110049#
is described by: ECO:0000000

metaR GALACGLCGALGBSIDEtg
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
name: galacglcgalgbside hs intracellular transport

metaM ksi deg38 l
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 38
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false

metaR r0652
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110049#
type: Reaction

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_bfda6d00_973b_4d7c_a91a_1cc56d467c0d
is encoded by: hsa:8883
name: NAE1
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: A8MU28
type: Species
initial concentration: NaN

metaM HC01118 r
name: presqualene diphosphate(3-)
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57310

metaR PTPATe
name: PTPATe
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110049#
is described by: ECO:0000134
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110049#

metaM q10h2 c
is: HMDB13111
initial concentration: 1.0
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
is: SBO:0000247
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_bfc2bf67_6b53_40c3_8899_3a9503c67289
has only substance units: false
is encoded by: hsa:6561
constant: false
is: SBO:0000252
is: Q9BZW2
boundary condition: true
initial amount: NaN
name: SLC13A1
initial concentration: NaN
type: Species

metaR r2372
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaM 2mbcoa m
name: 2-methylbutanoyl-CoA(4-)
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: SBO:0000247
is: HMDB01041
boundary condition: false
constant: false
type: Species
is: CHEBI:57336
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM 3pg m
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
has only substance units: false
constant: false
is: HMDB00807
is: CHEBI:58272
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
boundary condition: false
initial amount: NaN

metaM pi n
initial concentration: 1.0
is: HMDB00973
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:43474
type: Species
name: hydrogenphosphate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_77e588ec_50c3_4694_a0e6_99292855bb23
name: SDR16C5
boundary condition: true
has only substance units: false
initial concentration: NaN
is: B3KT84
constant: false
is: SBO:0000252
is encoded by: hsa:195814
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_f23183c5_d728_4453_8515_966fb4f752dd
type: Species
has only substance units: false
is encoded by: hsa:2182
is: Q5JWV8
boundary condition: true
name: ACSL4
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaM thbpt4acam c
is: HMDB02281
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
initial concentration: 1.0

metaM gua e
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00132
boundary condition: false
type: Species
is: CHEBI:16235
initial concentration: 1.0
constant: false
name: guanine
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242

http://identifiers.org/biomodels.db/MODEL1310110049#_f2554afa_7641_45ae_af96_a384ae3c1ebb
type: Species
constant: false
is: O00476
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SLC17A3
initial amount: NaN
is encoded by: hsa:10786

metaR r2379
kinetic law: MODEL1310110049#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reversible: true
reactant: MODEL1310110049#

metaR GALACGLCGALGBSIDEte
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
type: Reaction
reactant: MODEL1310110049#
fast: false
reversible: true
name: galacglcgalgbside hs transport
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaR G16MT U
fast: false
reversible: false
product: MODEL1310110049#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110049#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110049#_89b827fa_b028_4df9_a040_3e5306fec0d4
boundary condition: true
type: Species
is encoded by: hsa:57282
has only substance units: false
name: SLC4A10
is: SBO:0000252
constant: false
initial concentration: NaN
is: B7Z1R0
initial amount: NaN

metaM icit x
initial amount: NaN
name: isocitrate(3-)
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16087
is: HMDB00193
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_cce1e94e_e999_4051_99da_dfa3dc6b914e
initial amount: NaN
is: Q9BZQ4
is encoded by: hsa:23057
is: SBO:0000252
constant: false
boundary condition: true
name: NMNAT2
initial concentration: NaN
type: Species
has only substance units: false

metaR ASCBt
name: L-ascorbate transport via facilitated diffusion
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_227ba735_30e6_4bb9_bcec_04d4401e8ec0
has only substance units: false
is: Q07837
name: SLC3A1
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:6519
type: Species
initial concentration: NaN
is: SBO:0000252

metaM fru c
is: CHEBI:15824
constant: false
is: SBO:0000247
name: D-Fructose
is: HMDB00660
initial concentration: 1.0
initial amount: NaN
is: C00095
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095

metaR r0650
is version of: http://identifiers.org/ec-code/4.1.1.36
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110049#

metaM ala L m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: L-alanine
is: CHEBI:16977
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

metaR UAG4E
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
name: UDP-N-acetylglucosamine 4-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
modifier: MODEL1310110049#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaM ocdcea c
constant: false
initial amount: NaN
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: C00712
is: HMDB00207
has only substance units: false
is: SBO:0000247
is: CHEBI:0
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false

metaR GLCNACT U
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110049#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9e4afe03_52b5_4c5a_b95b_a02f8efd8194
is: Q10469
is encoded by: hsa:4247
initial amount: NaN
name: MGAT2
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r2378
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110049#
is described by: ECO:0000000

metaM k e
is: C00238
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: HMDB00586
initial amount: NaN
name: potassium
initial concentration: 1.0
has only substance units: false
is: CHEBI:29103
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c4863af3_e72b_4907_af66_31bd146e1c0b
name: AK4
is: P27144
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:205
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

metaR AG13T5g
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR S6T18g
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
modifier: MODEL1310110049#
type: Reaction
reversible: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.8.2.21
product: MODEL1310110049#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM prostgi2 c
is: CHEBI:57403
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: prostaglandin I2(1-)
is: HMDB01335
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false

metaM fru e
is: CHEBI:15824
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
boundary condition: false
initial concentration: 1.0
name: D-Fructose
initial amount: NaN
is: C00095
type: Species
constant: false
is: HMDB00660

metaR r2377
reactant: MODEL1310110049#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110049#
reversible: true
fast: false

metaM C05965 e
is: CHEBI:57444
boundary condition: false
name: 12(S)-HPETE(1-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB04243
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
type: Species

metaM HC01007 x
boundary condition: false
is: CHEBI:18102
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
name: L-Octanoylcarnitine
has only substance units: false
type: Species

metaR MACACI
modifier: MODEL1310110049#
is described by: ECO:0000269
reversible: false
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: maleylacetoacetate isomerase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD

metaM pi m
type: Species
constant: false
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
initial amount: NaN
is: CHEBI:43474
name: hydrogenphosphate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C00009

metaR DHCRD1
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
is described by: ECO:0000269
kinetic law: MODEL1310110049#
name: dihydroceramide desaturase
type: Reaction
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is: SBO:0000176
fast: false

metaR r2376
kinetic law: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110049#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000

metaR ALOX52
is: SBO:0000176
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.34
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
name: Arachidonate 5-lipoxygenase
fast: false
type: Reaction
reversible: false

metaM k c
constant: false
is: C00238
type: Species
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
has only substance units: false
name: potassium
initial concentration: 1.0
is: HMDB00586
initial amount: NaN
is: CHEBI:29103
boundary condition: false

metaM mescon m
name: Mesaconate
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: CHEBI:36986
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00749
boundary condition: false
has only substance units: false

metaM acglcgalgbside hs g
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:26174
type: Species
initial amount: NaN
name: GlcNAc-Gal globoside
boundary condition: false
is: SBO:0000247
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110049#_0d287577_6ed3_4639_81c0_89673dee464d
boundary condition: true
is: P04745
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:277
initial concentration: NaN
name: AMY1B
initial amount: NaN

metaM lald D c
boundary condition: false
name: (R)-lactaldehyde
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17167
constant: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
initial concentration: 1.0
is: HMDB06458

metaM 56dura c
is: SBO:0000247
type: Species
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: CHEBI:15901
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00076
boundary condition: false
initial amount: NaN
name: 5,6-dihydrouracil

metaM 5mdr1p c
constant: false
initial concentration: 1.0
is: HMDB00963
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H11O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02120 EHMN_ABBREVIATION: C04188
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate
is: SBO:0000247
is: CHEBI:58533
is: C04188

metaM ins c
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
boundary condition: false
initial concentration: 1.0
is: C00294
constant: false
type: Species
initial amount: NaN
is: CHEBI:17596
has only substance units: false
is: HMDB00195
name: Inosine

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_bf9aa8cb_b958_4c8f_bc79_4cb1021a0c03
is: SBO:0000252
has only substance units: false
is: Q86YW0
type: Species
initial concentration: NaN
is encoded by: hsa:89869
constant: false
name: PLCZ1
boundary condition: true
initial amount: NaN

metaR KHte
reactant: MODEL1310110049#
product: MODEL1310110049#
name: KHte
type: Reaction
kinetic law: MODEL1310110049#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185

metaM thbpt4acam n
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
is: HMDB02281
type: Species
boundary condition: false
constant: false
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
is: CHEBI:15374

http://identifiers.org/biomodels.db/MODEL1310110049#_f8129b18_efee_45c0_9f7b_606a9b0c59c1
boundary condition: true
is encoded by: hsa:4541
is: Q7GXZ1
name: ND6
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM g1p c
initial amount: NaN
is: C00103
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: HMDB01586
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58601
boundary condition: false
name: D-Glucose 1-phosphate
type: Species

metaR THRASNNaEx
kinetic law: MODEL1310110049#
type: Reaction
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
fast: false
is described by: ECO:0000269
is: SBO:0000185
reversible: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110049#
reactant: MODEL1310110049#

metaR ALDD2xm
is: SBO:0000176
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
fast: false
reversible: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110049#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110049#

metaR FUMAC
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110049#
type: Reaction
name: fumarylacetoacetase
modifier: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.7.1.2
kinetic law: MODEL1310110049#
reversible: false

metaR NADPtxu
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
reactant: MODEL1310110049#
name: NADP transporter, peroxisome
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_5709ec95_c40e_4d0a_a7ef_8f05f86a55cd
type: Species
initial concentration: NaN
is encoded by: hsa:10797
is: P13995
initial amount: NaN
name: MTHFD2
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaM amp r
is: CHEBI:456215
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00045
initial concentration: 1.0
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
has only substance units: false
is: C00020
type: Species

metaR A MANASEly
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
modifier: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.24
fast: false
name: alpha-mannosidase, lysosomal
is: SBO:0000176
reversible: false

metaR H2MTer U
product: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
reactant: MODEL1310110049#
name: H2 mannosyltransferase, endoplasmic reticulum
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_dce145ce_fa4a_4dd5_b16a_567059dd3307
type: Species
constant: false
is: Q8TDB8
initial concentration: NaN
name: SLC2A14
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:144195

metaR UMPK
reversible: true
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110049#
fast: false
type: Reaction
modifier: MODEL1310110049#
name: UMP kinase

http://identifiers.org/biomodels.db/MODEL1310110049#_11800228_0776_4f4c_b52e_b93c8961bcad
constant: false
is encoded by: hsa:4166
is: SBO:0000252
type: Species
is: Q9GZX3
boundary condition: true
initial concentration: NaN
name: CHST6
initial amount: NaN
has only substance units: false

metaR r0345
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: true
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_cc569ad0_3b0e_4964_9b6b_0e14ec510221
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:NM 001929
name: _NM_001929_1_c
initial amount: NaN

metaM ins e
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: HMDB00195
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17596
boundary condition: false
constant: false
is: C00294
type: Species

metaR r0870
modifier: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/3.1.3.4
fast: false
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/2.7.7.72
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaM CE4790 m
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
has only substance units: false
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:15748
is: HMDB00127
initial amount: NaN

metaR r0559
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1

metaR CYTK9n
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP),nuclear
product: MODEL1310110049#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_ef8e7e30_c8ce_4748_b5e8_023371d93673
is encoded by: hsa:7915
is: Q546H9
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ALDH5A1
constant: false
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_ec528868_be8f_4638_b9c6_0f2ce09cab04
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AA177072_1_x
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AA177072
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_64e8a157_075e_47a2_85b1_9736525ed5df
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q14749
boundary condition: true
is encoded by: hsa:27232
name: GNMT
has only substance units: false
is: SBO:0000252

metaR r0647
product: MODEL1310110049#
name: Spontaneous reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_1dbc2a75_9efd_400a_a766_f7a3d13946a8
is encoded by: hsa:2585
is: Q01415
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: GALK2
type: Species

metaM gua c
is: HMDB00132
name: Guanine
type: Species
is: CHEBI:16235
is: C00242
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN

metaM acmana c
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
initial amount: NaN
is: CHEBI:17122
name: N-acetyl-D-mannosamine
initial concentration: 1.0
is: HMDB01129

metaM udpglcur r
has only substance units: false
initial amount: NaN
is: CHEBI:58052
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
name: UDP-D-glucuronate
is: C00167
is: HMDB00935

metaM CE5236 c
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
constant: false
is: CHEBI:28002
type: Species
has only substance units: false
initial amount: NaN
is: HMDB03952
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236

metaM 13dpg c
is: CHEBI:57604
is: C00236
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
constant: false
initial amount: NaN
is: HMDB01270
name: 3-Phospho-D-glyceroyl phosphate
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3535

metaR DHPR
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.6.99.7 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:
is: SBO:0000176
name: 6,7-dihydropteridine reductase
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110049#
type: Reaction
fast: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.5.1.34
product: MODEL1310110049#

metaM galside hs c
constant: false
type: Species
has only substance units: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false

metaR r0558
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
modifier: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_a446488f_21c7_4b9b_833b_51614f5e76bd
type: Species
is: Q5MY95
has only substance units: false
name: ENTPD8
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:377841
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_f8633e60_98ef_4872_9644_66ff640b2227
is encoded by: hsa:3632
is: SBO:0000252
is: Q14642
initial concentration: NaN
constant: false
boundary condition: true
name: INPP5A
has only substance units: false
initial amount: NaN
type: Species

metaR RAtn3
product: MODEL1310110049#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: 13-cis-retinoic acid transport, nuclear
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true

metaR SUCCt2m
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
name: succinate transport, mitochondrial
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_7311a341_527a_4397_b072_fe01b77786eb
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:79717
name: PPCS
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9HAB8

metaR r2059
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_10b637d0_a31a_4805_ac21_c91f58867ce5
constant: false
name: ALDH3A1
initial amount: NaN
has only substance units: false
is: P30838
is: SBO:0000252
is encoded by: hsa:218
boundary condition: true
initial concentration: NaN
type: Species

metaM HC01444 e
initial concentration: 1.0
is: CHEBI:15754
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
has only substance units: false
name: Galactosylglycerol

metaR G14T12g
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176

metaR PYNP2r
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
name: pyrimidine-nucleoside phosphorylase (uracil)
reactant: MODEL1310110049#

metaR FMNAT
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.7.2
type: Reaction
reversible: false
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
name: FMN adenylyltransferase
modifier: MODEL1310110049#

metaR C3STDH1Pr
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
fast: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is described by: ECO:0000134
kinetic law: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.170
modifier: MODEL1310110049#
reversible: false
is: SBO:0000176
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_e5233e75_2ade_4a04_bafc_c4bb3e16bb87
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: _AI435857_1_x
type: Species
is encoded by: hsa:AI435857

metaM gm3 hs g
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:60065
constant: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)

metaM arachcrn c
name: arachidyl carnitine
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: HMDB06460
boundary condition: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_735b2ac8_5ca9_435c_9e19_9a2aeb3d5328
initial amount: NaN
name: INPP5J
boundary condition: true
is encoded by: hsa:27124
initial concentration: NaN
type: Species
is: Q15735
has only substance units: false
is: SBO:0000252
constant: false

metaM ala L e
type: Species
is: HMDB00161
constant: false
name: L-alanine
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0
is: CHEBI:16977
has only substance units: false

metaR EX pydam LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_5c7457ba_400f_4110_848a_2d072193a2b2
boundary condition: true
constant: false
name: ECHS1
is encoded by: hsa:1892
is: P30084
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_2d962fd5_74ee_4307_9728_a82b8313bf55
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4537
constant: false
name: ND3
is: P03897

http://identifiers.org/biomodels.db/MODEL1310110049#_d3b409d3_7fbf_4973_9ea0_0d520275d127
is encoded by: hsa:2720
constant: false
initial amount: NaN
name: GLB1
type: Species
is: SBO:0000252
initial concentration: NaN
is: P16278
has only substance units: false
boundary condition: true

metaR PCHOL HSter
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#
name: phosphatidylcholine scramblase
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM HC01104 e
is: CHEBI:61146
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
name: 4-nitrophenyl phosphate(2-)
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_9baa9e4d_bec1_4a6c_ab99_214129d40af2
initial concentration: NaN
type: Species
name: ADSS
is: SBO:0000252
is: P30520
initial amount: NaN
is encoded by: hsa:159
constant: false
boundary condition: true
has only substance units: false

metaM zymst r
name: zymosterol
is: CHEBI:18252
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB06271
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437

http://identifiers.org/biomodels.db/MODEL1310110049#_df808350_e3a0_49b2_937b_c0aa8c392a9d
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: Q9H008
is encoded by: hsa:64077
name: LHPP
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_41ecf399_6f6a_4ee5_ba17_7662e72e7bff
constant: false
type: Species
is: SBO:0000252
name: SLC2A9
boundary condition: true
is encoded by: hsa:56606
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_676f9114_6f67_4bc6_b313_a5ee6059e446
initial concentration: NaN
boundary condition: true
name: DPM2
has only substance units: false
constant: false
initial amount: NaN
is: O94777
is: SBO:0000252
type: Species
is encoded by: hsa:8818

metaR GLCNACPT U
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110049#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
is version of: http://identifiers.org/ec-code/2.7.8.15
reversible: false
fast: false
product: MODEL1310110049#

metaR C204CPT2
reversible: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: arachidonic acid transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
product: MODEL1310110049#

metaR RE3421R
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: RE3421
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
fast: false

metaM aacoa m
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
constant: false
type: Species
initial amount: NaN
is: CHEBI:57286
name: acetoacetyl-CoA(4-)
has only substance units: false
boundary condition: false
is: HMDB01484
initial concentration: 1.0
is: SBO:0000247

metaM ksii core4 pre7 g
type: Species
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: C00130
name: keratan sulfate II biosynthesis, precursor 7
is: CHEBI:58053
has only substance units: false
is: SBO:0000247
is: HMDB00175
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_f13927d8_e8e4_4af0_9f99_ec2cf2784ae9
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:204
boundary condition: true
has only substance units: false
name: AK2
initial concentration: NaN

metaR r0644
is described by: ECO:0000000
reversible: true
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110049#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

metaR EX ebastine LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ebastine exchange
type: Reaction

metaR B3GNT32g
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is described by: ECO:0000269
reactant: MODEL1310110049#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110049#_bee866b2_6a21_4ebe_8bcb_3939db15b64f
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI926493
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: _AI926493_1_c

metaR ACACt2m
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110049#
name: Acetoacetate mitochondrial transport via H+ symport
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_0828333b_4c25_4b05_aa55_badc07a89a0a
initial amount: NaN
is encoded by: hsa:1629
boundary condition: true
constant: false
initial concentration: NaN
is: P11182
has only substance units: false
name: DBT
is: SBO:0000252
type: Species

metaM ala L c
name: L-alanine
type: Species
is: HMDB00161
boundary condition: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16977

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM biocyt c
constant: false
boundary condition: false
type: Species
is: HMDB03134
initial concentration: 1.0
name: Biocytin
initial amount: NaN
has only substance units: false
is: C05552
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

metaR r0409
fast: false
is: SBO:0000176
reversible: true
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
reactant: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.10

metaM galside hs g
initial amount: NaN
has only substance units: false
name: D-galactosyl-N-acylsphingosine
constant: false
type: Species
is: CHEBI:12947
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_539896b1_8c77_4f99_ad25_66970bde8720
boundary condition: true
constant: false
is: B3KTV4
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:122622
name: ADSSL1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_e1783f6d_4e2b_4530_b4e9_24bc81c57b6a
is: SBO:0000252
initial concentration: NaN
is: Q16850
constant: false
is encoded by: hsa:1595
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: CYP51A1

http://identifiers.org/biomodels.db/MODEL1310110049#_06e658fd_d14f_4218_be85_b7341cfb0df6
type: Species
is encoded by: hsa:34
is: P11310
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ACADM
initial amount: NaN
is: SBO:0000252
constant: false

metaR SERCYSNaEx
reversible: false
is described by: ECO:0000269
product: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
type: Reaction

metaR r0755
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110049#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000176

metaM g1m8masn r
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: C05875
is: SBO:0000247
has only substance units: false

metaR ACCOAtr
name: acetyl-coa transport
product: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#

metaR r0408
is version of: http://identifiers.org/ec-code/1.4.3.5
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11

metaM ksi deg24 l
is: SBO:0000247
constant: false
is: HMDB00143
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate I, degradation product 24

metaR THBPT4ACAMDASE
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
product: MODEL1310110049#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110049#
is described by: ECO:0000269
reactant: MODEL1310110049#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
kinetic law: MODEL1310110049#

metaR DHCR71r
is version of: http://identifiers.org/ec-code/1.3.1.21
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
name: 7-dehydrocholesterol reductase
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000134
modifier: MODEL1310110049#
reversible: false

metaM cmpacna c
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
is: CHEBI:57812
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01176
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_bf52c726_0584_4731_8ad4_880b399ee461
initial concentration: NaN
constant: false
name: SLC4A8
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9498
boundary condition: true
is: E7EML0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_59dc1302_9e58_4c7f_a353_d9d6f795770c
name: NME1:NME2
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:4830
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110049#_e8768347_c3b5_46a5_a9f0_c8fa7bb2fe11
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA177072
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AA177072_1_c
constant: false

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR NDPK5n
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
type: Reaction
product: MODEL1310110049#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110049#_db0277df_07fb_4018_b403_3e1030210bfc
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
initial concentration: NaN
has part: Q6NZ59
constant: false
is encoded by: hsa:522

metaR PGLer
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
reactant: MODEL1310110049#
product: MODEL1310110049#
name: 6-phosphogluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
is described by: ECO:0000269

metaR r0754
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000176
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
fast: false
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110049#
product: MODEL1310110049#

metaR r0407
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is: SBO:0000176
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reversible: true
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000000
reactant: MODEL1310110049#

metaM icit c
boundary condition: false
is: C00311
type: Species
initial concentration: 1.0
name: Isocitrate
has only substance units: false
is: CHEBI:16087
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false
is: SBO:0000247
is: HMDB00193

http://identifiers.org/biomodels.db/MODEL1310110049#_dde8e6bd_4f75_4dc9_b989_05870c80eac8
boundary condition: true
is: Q9Y2B2
initial amount: NaN
has only substance units: false
name: PIGL
is encoded by: hsa:9487
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaM 34dhoxmand m
is: CHEBI:27637
initial amount: NaN
constant: false
is: HMDB01866
boundary condition: false
name: 3,4-Dihydroxymandelate
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

metaR DOPASFt
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
type: Reaction
reactant: MODEL1310110049#
name: Dopamine 3-0-sulfate transport (diffusion)
reversible: false
is: SBO:0000185

metaR RE3628M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
modifier: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110049#
name: RE3628
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_4ae319c2_5b2d_4a0b_b05b_5da8ba062331
boundary condition: true
initial amount: NaN
name: PDE4A
is encoded by: hsa:5141
type: Species
is: P27815
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_f83c1442_fc84_4f75_ba41_c6bc5f0eee1c
initial amount: NaN
name: ACOT1
is: E9KL42
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:641371
is: SBO:0000252
constant: false

metaR r2056
is: SBO:0000185
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110049#_38b8b011_26ec_4b1d_a176_57a012e5abaa
name: BAAT
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:570
is: Q14032

metaM galside hs l
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR r0753
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
product: MODEL1310110049#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_a313c639_b3c9_406e_8639_adeeef64b409
type: Species
initial amount: NaN
has only substance units: false
is: P18859
initial concentration: NaN
name: ATP5J
is: SBO:0000252
boundary condition: true
is encoded by: hsa:522
constant: false

metaR r1380
fast: false
is: SBO:0000176
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_ed31564f_2325_414a_8b23_4cad0518a553
initial amount: NaN
is: Q9Y672
has only substance units: false
is encoded by: hsa:29929
boundary condition: true
name: ALG6
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR GALASE20ly
product: MODEL1310110049#
fast: false
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction

metaM dhap c
name: Dihydroxyacetone phosphate
type: Species
boundary condition: false
constant: false
is: C00111
is: CHEBI:57642
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/3411
is: HMDB01473

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_9a679324_802f_404e_8fe8_c615ad413c3a
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6648
name: SOD2
is: P04179
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM ha pre1 l
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:16126
name: hyaluronan biosynthesis, precursor 1
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN
is: SBO:0000247

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110049#
fast: false
name: beta-galactosidase, lysosomal

metaR r0752
kinetic law: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110049#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
modifier: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_7e54ccfb_9f1b_4894_96cd_87c7d5dbbc01
name: MVD
has only substance units: false
type: Species
is encoded by: hsa:4597
initial concentration: NaN
is: P53602
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR r1381
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110049#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
is: SBO:0000176
product: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM ach n
type: Species
has only substance units: false
is: CHEBI:15355
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_2b279ab3_8c04_4fc9_8e02_7bfa58c5f86a
is: Q92835
name: INPP5D
has only substance units: false
is encoded by: hsa:3635
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_7c937c8c_e110_424c_a33d_6e074939d8e8
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: NME1
type: Species
is encoded by: hsa:4830
constant: false
initial amount: NaN
boundary condition: true

metaM Rtotal3 e
type: Species
name: R total 3 position
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:3554
has only substance units: false
initial amount: NaN
is: HMDB00244
is: C00255
is: SBO:0000247
notes: FORMULA: CO2FULLR3 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110049#_afcfa6e8_5c73_4bc2_b399_ed6d7a58e11d
is: SBO:0000252
name: BCKDHB
is encoded by: hsa:594
has only substance units: false
initial amount: NaN
is: Q9BQL0
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM aacoa x
is: CHEBI:57286
is: HMDB01484
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: acetoacetyl-CoA(4-)
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM amp m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:456215
name: AMP(2-)
type: Species
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
initial concentration: 1.0

metaR ACCOAtn
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
name: acetyl-CoA transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110049#

metaM arachcrn m
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: arachidyl carnitine
constant: false
type: Species
has only substance units: false
is: HMDB06460

metaM biocyt n
name: Biocytin
is: C05552
constant: false
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
is: HMDB03134

metaR N3Tg
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
reversible: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.122
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
fast: false
reactant: MODEL1310110049#
type: Reaction

metaM ksii core4 pre2 g
is: C00130
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial amount: NaN
is: CHEBI:58053
constant: false
is: HMDB00175
is: SBO:0000247
has only substance units: false
name: keratan sulfate II boisynthesis, precursor 2
type: Species

metaR ADNt4
is described by: ECO:0000269
type: Reaction
product: MODEL1310110049#
name: adenosine transport (Na/Adn cotransport)
is: SBO:0000185
fast: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
reversible: false

metaM cmpacna g
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
type: Species
is: HMDB01176
boundary condition: false
initial concentration: 1.0

metaR GLCNACPT L
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
is version of: http://identifiers.org/ec-code/2.7.8.15
reversible: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false

metaM ksii core4 pre10 g
initial amount: NaN
constant: false
name: keratan sulfate II biosynthesis, precursor 10
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
boundary condition: false
is: CHEBI:28067
initial concentration: 1.0

metaM dhap e
constant: false
name: glycerone phosphate(2-)
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial amount: NaN
is: CHEBI:57642
boundary condition: false
is: SBO:0000247
is: HMDB01473
type: Species
has only substance units: false
initial concentration: 1.0

metaM 5adtststerones c
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032

metaR r1707
is: SBO:0000185
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_ee66e829_ad5d_4672_9bc9_388d6b373b1a
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6120
boundary condition: true
name: RPE
is: Q53TV9
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM glu5p m
initial amount: NaN
is: HMDB01228
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: SBO:0000247
type: Species
name: L-Glutamate 5-phosphate
boundary condition: false
is: CHEBI:58274
constant: false
initial concentration: 1.0
has only substance units: false

metaM HC01672 c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
boundary condition: false
type: Species
has only substance units: false
name: Acetyl adenylate
is: CHEBI:37666

metaM biocyt m
constant: false
is: HMDB03134
name: Biocytin
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: C05552

http://identifiers.org/biomodels.db/MODEL1310110049#_1cda1826_49c5_4735_bad1_2922d69cadc4
initial amount: NaN
boundary condition: true
is: C9JZ62
constant: false
initial concentration: NaN
name: TMEM91
is encoded by: hsa:641649
has only substance units: false
is: SBO:0000252
type: Species

metaR r0758
fast: false
is: SBO:0000176
modifier: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_99d49f84_dfd6_4582_bb4e_7744d1b5d678
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:22934
name: RPIA
initial amount: NaN
is: P49247

metaR VALtec
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185
product: MODEL1310110049#
name: L-valine transport via diffusion (extracellular to cytosol)
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR C160CPT2
is: SBO:0000176
name: C160 transport into the mitochondria
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269

metaR r0403
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: true
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4

http://identifiers.org/biomodels.db/MODEL1310110049#_3f85bf4a_b88a_4d73_9cf5_1f04431b9013
is encoded by: hsa:5625
name: PRODH
initial amount: NaN
is: O43272
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r0119
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110049#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
fast: false
reversible: false

metaM CE5236 n
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
initial amount: NaN
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:28002
is: SBO:0000247

metaR 5MTHFt2le
is described by: ECO:0000134
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: 5-methyltetrahydrofolate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110049#
type: Reaction

metaR SUCD1m
name: succinate dehydrogenase
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1

metaM 12ppd R c
initial amount: NaN
is: CHEBI:28972
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01881
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
name: (R)-propane-1,2-diol
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_ac06006d_0317_4db6_aaf1_3d365318719e
is: SBO:0000252
is: O43677
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4717
name: NDUFC1

http://identifiers.org/biomodels.db/MODEL1310110049#_5ab0be01_cbfe_4ae0_9c23_138164314ef1
boundary condition: true
is: SBO:0000252
name: DGKG
constant: false
has only substance units: false
is encoded by: hsa:1608
is: P49619
initial concentration: NaN
type: Species
initial amount: NaN

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
is: SBO:0000176

metaR AG13T15g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#

metaM 5adtststerones e
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: HMDB06278
initial concentration: 1.0
has only substance units: false

metaR FAOXC200180m
name: Beta oxidation of long chain fatty acid
product: MODEL1310110049#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is: SBO:0000176

metaM crn x
is: CHEBI:16347
is: HMDB00062
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: C00318
name: L-Carnitine
constant: false
initial amount: NaN
has only substance units: false

metaM m7mpdol U r
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
is: SBO:0000247
constant: false
is: CHEBI:37636
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_1995da78_5441_4f61_8e86_6cb8af4dc473
is: SBO:0000252
constant: false
initial concentration: NaN
is: O14521
has only substance units: false
boundary condition: true
is encoded by: hsa:6392
initial amount: NaN
type: Species
name: SDHD

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_962cdd85_a126_466b_b690_e1ede2e9bbce
name: MGLL
is: B2ZGL7
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11343

metaR It
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110049#
reactant: MODEL1310110049#
name: Iodide uniport
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110049#

metaR GLYSNAT5tc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR LNLNCGt
is described by: ECO:0000000
product: MODEL1310110049#
name: fatty acid transport via diffusion
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR r0340
fast: false
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110049#

metaM dgchol e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:36252
name: glycochenodeoxycholate
type: Species

metaM strch2 e
constant: false
notes: FORMULA: C18H32O16 CHARGE: 0
is: CHEBI:4167
boundary condition: false
type: Species
initial concentration: 1.0
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
initial amount: NaN
is: HMDB00122
has only substance units: false
is: SBO:0000247

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR r1377
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaM malthx e
name: Maltohexaose
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: C01936

metaR C4CRNe
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaM leuktrF4 e
has only substance units: false
boundary condition: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
is: HMDB06465
name: leukotriene F4
type: Species
initial amount: NaN
is: CHEBI:27491
initial concentration: 1.0
is: SBO:0000247

metaR H2Otp
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000000
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true

metaR RE3005M
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
fast: false
name: RE3005
modifier: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaM 13 cis retn n
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
name: 13-cis-retinoate
has only substance units: false
constant: false
is: D00348
is: http://identifiers.org/pubchem.compound/7847414
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: HMDB06219

metaM ha pre1 e
is: CHEBI:16126
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
initial amount: NaN
name: hyaluronan biosynthesis, precursor 1

metaR r2497
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is: SBO:0000185
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:

metaM n2m2masn g
boundary condition: false
initial concentration: 1.0
is: C11530
has only substance units: false
type: Species
notes: FORMULA: C50H83N4O35X CHARGE: 0
initial amount: NaN
constant: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_1b9a6797_8168_4937_a6bb_6e07dbac10e7
name: AK7
is: Q96M32
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:122481
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR G12MT1 L
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
reversible: false
type: Reaction

metaM dadp c
is: C00206
type: Species
boundary condition: false
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: dADP
is: CHEBI:57667
initial amount: NaN

metaM arachdcrn c
initial concentration: 1.0
name: C20:4 carnitine
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57387
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01322

metaM pcrn c
is: http://identifiers.org/pubchem.compound/107738
is: HMDB00824
name: propionyl-carnitine
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaR ACGBGBSIDEtl
type: Reaction
name: acgbgbside hs intracellular transport
reactant: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
is described by: ECO:0000000
product: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#

metaR AG13T4g
is: SBO:0000176
modifier: MODEL1310110049#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#

metaR ASPDTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
is described by: ECO:0000134
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: D-aspartate transport, extracellular
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#

metaM mpdol L c
initial concentration: 1.0
is: CHEBI:18396
type: Species
constant: false
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog

metaM dhap x
is: CHEBI:57642
constant: false
name: Dihydroxyacetone phosphate
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/3411
is: C00111
has only substance units: false
is: SBO:0000247
is: HMDB01473
initial concentration: 1.0
initial amount: NaN

metaM leuktrF4 c
is: CHEBI:27491
is: SBO:0000247
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
name: leukotriene F4
constant: false
is: HMDB06465
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR H2Otn
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110049#
fast: false
name: H2O transport, nuclear
type: Reaction
is described by: ECO:0000000
reversible: true

metaR r0960
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_cc954dd5_39c4_4e1a_8a66_441b7e39ebc3
constant: false
name: _C7orf24_1_m
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:C7orf24
type: Species
boundary condition: true
initial amount: NaN

metaR r1378
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reversible: true
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_719f03c3_0c63_437c_9b3b_810dd334485e
is encoded by: hsa:6563
is: SBO:0000252
name: SLC14A1
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: G0W2N5
initial concentration: NaN

metaR r0400
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: true
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
modifier: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#

metaR 10FTHFtm
type: Reaction
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110049#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_f76b17e3_437a_469c_8c49_84eb11f613c7
is: P14550
constant: false
has only substance units: false
type: Species
is encoded by: hsa:10327
name: AKR1A1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR PROt4 2 r
name: Proline transport (sodium symport) (2:1)
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000006
type: Reaction
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110049#

metaR H2Otm
fast: false
reversible: true
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
name: H2O transport, mitochondrial
kinetic law: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_b0c7aa12_23df_4fdc_ba3e_558a865c7aa7
type: Species
name: ACOT6
is: SBO:0000252
is: Q3I5F7
boundary condition: true
is encoded by: hsa:641372
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_c36b5a14_3b67_444d_95b2_da403f343cbe
type: Species
is: SBO:0000252
name: COX4I1
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:1327
is: P13073

metaM gdpfuc c
has only substance units: false
is: CHEBI:57984
name: GDP-L-fucose(2-)
is: HMDB01095
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_7d0d70f3_5c57_4a8e_af00_ad5db395035f
is: Q9NY97
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: B3GNT2
is encoded by: hsa:10678

metaR DNDPt35m
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000269
name: dGDP transport via dADP antiport
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110049#

metaM lpchol hs e
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
boundary condition: false
is: CHEBI:60479
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: lysophosphatidylcholine

http://identifiers.org/biomodels.db/MODEL1310110049#_fdf3ab8f_908a_40f6_8480_aad71af567ac
is encoded by: hsa:34
has only substance units: false
boundary condition: true
name: ACADM
initial amount: NaN
is: P11310
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaR IMPC
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
name: IMP cyclohydrolase
is: SBO:0000176
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_c900b37b_1a39_4a85_a24b_d8d797d5756a
has only substance units: false
is encoded by: hsa:65985
initial concentration: NaN
boundary condition: true
name: AACS
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: Q86V21

metaR r2381
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_023b950b_8dd0_455b_a81f_a50d764ffbf5
initial amount: NaN
is: SBO:0000252
type: Species
is: Q969K7
is encoded by: hsa:113452
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: TMEM54

metaR FAOXC18480m
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
type: Reaction
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_63467d84_85b1_46ab_ae46_19acdaa1f640
initial concentration: NaN
is: Q96EK6
initial amount: NaN
has only substance units: false
type: Species
name: GNPNAT1
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:64841

metaR r0962
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110049#
is: SBO:0000185

metaR RE2625M
modifier: MODEL1310110049#
type: Reaction
reversible: true
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE2625
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176

metaR G14T21g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR RPI
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
product: MODEL1310110049#
fast: false
name: ribose-5-phosphate isomerase
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_1ab1bcc2_f2f1_45dd_90a7_095081e407b7
constant: false
is encoded by: hsa:AI631997
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: _AI631997_1_m
boundary condition: true

metaR AHEXASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
type: Reaction
is: SBO:0000176
product: MODEL1310110049#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110049#
fast: false

metaR DRPA
product: MODEL1310110049#
reversible: false
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:

metaR r2380
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110049#
reversible: true
fast: false
type: Reaction

metaR r1154
is described by: ECO:0000000
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: EC:1.2.7.2
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
reactant: MODEL1310110049#
fast: false
type: Reaction

metaR BACCL
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000269
name: biotin-[acetyl-CoA-carboxylase] ligase
modifier: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
fast: false

metaM 13 cis retn r
is: D00348
is: HMDB06219
boundary condition: false
type: Species
initial amount: NaN
name: 13-cis-retinoate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: http://identifiers.org/pubchem.compound/7847414
constant: false
is: SBO:0000247

metaR UDPGLCAter
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
modifier: MODEL1310110049#
product: MODEL1310110049#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_6a24361b_ca47_4990_b6a0_28a2404f50a9
type: Species
is: B2RDZ2
name: RFK
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55312
initial concentration: NaN

metaM dopa c
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00073
is: CHEBI:59905
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)

metaM 1pipdn2c x
name: 1-piperideine-2-carboxylate
is: CHEBI:16187
initial concentration: 1.0
is: HMDB01084
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
boundary condition: false
type: Species
initial amount: NaN

metaR r0963
fast: false
kinetic law: MODEL1310110049#
type: Reaction
reversible: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is: SBO:0000185
name: Facilitated diffusion
reactant: MODEL1310110049#
is described by: ECO:0000000

metaR LPS3e
is described by: ECO:0000000
reversible: false
fast: false
name: lipase, extracellular
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9e2726b5_835f_4a82_afe4_0a4cbec807ce
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:1718
is: Q15392
initial concentration: NaN
boundary condition: true
name: DHCR24
constant: false
is: SBO:0000252

metaM dgchol c
constant: false
boundary condition: false
name: glycochenodeoxycholate
is: HMDB00637
initial amount: NaN
is: CHEBI:36252
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472

metaM lpchol hs c
boundary condition: false
is: CHEBI:60479
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: lysophosphatidylcholine
initial amount: NaN
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110049#_77e1074f_7f61_4f96_b65a_d01c93ccbfa4
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:3948
initial concentration: NaN
name: LDHC

http://identifiers.org/biomodels.db/MODEL1310110049#_fc398b61_a66c_4307_a718_d725788d324c
initial concentration: NaN
name: ATP5J2
initial amount: NaN
is: F8W7V3
boundary condition: true
constant: false
is encoded by: hsa:9551
type: Species
has only substance units: false
is: SBO:0000252

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reactant: MODEL1310110049#
name: beta-galactosidase, lysosomal
product: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110049#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR CHATn
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110049#
name: Choline O-acetyltransferase
product: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110049#_99e0f548_c463_4794_af85_b6a8770115b3
is encoded by: hsa:84002
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9BYG0
has only substance units: false
name: B3GNT5
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_0103527a_1c32_4bb7_b5d9_fa2dcf0681a5
is encoded by: hsa:1716
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: DGUOK
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_69d08bb8_67ac_44ce_b64d_86cd4cf90f8d
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:27115
name: PDE7B
has only substance units: false
is: Q9NP56
constant: false

metaR BILDGLCURt
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport

http://identifiers.org/biomodels.db/MODEL1310110049#_7b1e4db8_4fc7_4d5d_b01c_a450bf0dc576
initial amount: NaN
initial concentration: NaN
is: P22234
type: Species
is encoded by: hsa:10606
has only substance units: false
is: SBO:0000252
constant: false
name: PAICS
boundary condition: true

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR r2382
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_70e4300c_5027_46a5_a691_44baa4213d35
boundary condition: true
constant: false
name: SULT1A3
is: SBO:0000252
is encoded by: hsa:6818
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaR ACGBGBSIDEtg
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
is described by: ECO:0000000
name: acgbgbside hs intracellular transport
reversible: true
product: MODEL1310110049#

metaR RPE
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.1.3.1
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110049#
fast: false
name: ribulose 5-phosphate 3-epimerase
product: MODEL1310110049#
type: Reaction

metaR r1156
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

http://identifiers.org/biomodels.db/MODEL1310110049#_b630c755_ec94_4dd8_89bb_77e852abc8e4
type: Species
is: P04035
constant: false
is encoded by: hsa:3156
boundary condition: true
initial concentration: NaN
name: HMGCR
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d58209d6_675d_499e_8c42_b9e8f4a7ac29
initial concentration: NaN
type: Species
is encoded by: hsa:125
boundary condition: true
initial amount: NaN
has only substance units: false
name: ADH1B
is: SBO:0000252
constant: false
is: P00325

metaM dcmp n
is: CHEBI:57566
name: dCMP(2-)
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
boundary condition: false
has only substance units: false
is: HMDB01202
initial concentration: 1.0
initial amount: NaN

metaR ACACt2
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
fast: false
product: MODEL1310110049#
name: acetoacetate transport via proton symport
modifier: MODEL1310110049#

metaM m4masn g
is: C05881
initial concentration: 1.0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
constant: false

metaM cyan m
constant: false
is: HMDB02084
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
is: CHEBI:18407
initial concentration: 1.0
name: hydrogen cyanide
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR HAtly
is described by: ECO:0000000
reversible: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110049#
name: hyaluronan transport, extracellular to lysosome
reactant: MODEL1310110049#
is: SBO:0000185
type: Reaction

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaR r0853
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
is: SBO:0000185
reactant: MODEL1310110049#
name: Facilitated diffusion
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_e
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: HMDB01206
is: CHEBI:57288
boundary condition: false
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
name: Type IIIAb

http://identifiers.org/biomodels.db/MODEL1310110049#_ff03a357_858b_4020_8d97_f4936b0126c7
boundary condition: true
is encoded by: hsa:51727
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: B2R6S5
type: Species
name: CMPK1
has only substance units: false

metaR UNK3
is described by: ECO:0000000
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
is: SBO:0000176
name: 2-keto-4-methylthiobutyrate transamination
reversible: false
fast: false
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_bbb26a53_1b15_4ea6_861b_62324bc3237f
is encoded by: hsa:AI924226
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: _AI924226_1_m

metaR r2385
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110049#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
fast: false
reversible: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_67b0a485_9fc4_4eba_a215_4881415e85ef
is encoded by: hsa:151531
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: O95045
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: UPP2

http://identifiers.org/biomodels.db/MODEL1310110049#_2fcf5d7f_fae3_4041_b7b9_373ed473a9a0
is: Q96I99
has only substance units: false
is encoded by: hsa:8801
is: SBO:0000252
name: SUCLG2
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR G12MT1 U
fast: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_31e43596_9984_4a7b_82be_f9de9142d586
has only substance units: false
type: Species
is encoded by: hsa:5136
name: PDE1A
is: SBO:0000252
is: Q9Y633
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaM 4aphdob c
constant: false
boundary condition: false
is: CHEBI:58147
type: Species
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
has only substance units: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: SBO:0000247
is: HMDB00978
initial amount: NaN
initial concentration: 1.0

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR H2Otg
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
fast: false
reactant: MODEL1310110049#
name: H2O transport, Golgi apparatus
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_65011368_1cf6_42e0_9d08_8ee2a54bb856
is: SBO:0000252
has only substance units: false
name: PPT2
is encoded by: hsa:9374
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9UMR5
boundary condition: true
type: Species

metaR r2384
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
type: Reaction
reversible: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM zymstnl r
is: CHEBI:16608
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB06841
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
name: 5alpha-cholest-8-en-3beta-ol

http://identifiers.org/biomodels.db/MODEL1310110049#_23ab2756_04f6_4702_8c9a_c7d205a10a65
boundary condition: true
constant: false
initial concentration: NaN
name: DGUOK
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1716

http://identifiers.org/biomodels.db/MODEL1310110049#_4f897901_6f41_478b_8998_bae1cf83de11
is: Q15738
name: NSDHL
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:50814
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_6f6ee46a_f8bd_4e22_8d23_cec8c9cf869b
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9167
is: Q6FGA0
name: COX7A2L
is: SBO:0000252

metaM bildglcur c
boundary condition: false
type: Species
is: HMDB03325
constant: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
is: CHEBI:58471
initial concentration: 1.0
initial amount: NaN

metaR GLUTCOADHm
kinetic law: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.7
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
name: glutaryl-CoA dehydrogenase (mitochondria)
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110049#
type: Reaction

metaR r0641
is version of: http://identifiers.org/ec-code/3.1.2.4
reactant: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
product: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000000
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acgalfucgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:61648
type: Species
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
is: SBO:0000247
notes: FORMULA: C72H125N4O41FULLRCO CHARGE: 0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_c
is: SBO:0000247
type: Species
name: Type IIIAb
boundary condition: false
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01206
initial concentration: 1.0
is: CHEBI:57288

metaR r2387
is: SBO:0000185
fast: false
reactant: MODEL1310110049#
reversible: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
modifier: MODEL1310110049#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM dadp m
is: HMDB01508
name: dADP(3-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
is: CHEBI:57667
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR q10tm
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
name: transport of ubiquinone into mitochondria
reversible: true
is described by: ECO:0000134
type: Reaction
product: MODEL1310110049#

metaR r0552
modifier: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176
reactant: MODEL1310110049#
reversible: true
fast: false
product: MODEL1310110049#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_73bc482c_a868_49a3_81e6_016a6ab77ef1
initial concentration: NaN
type: Species
has part: Q5VYT2
has only substance units: false
constant: false
is encoded by: hsa:4731
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4712
is: SBO:0000297
initial amount: NaN
boundary condition: true

metaM gthox c
is: C00127
has only substance units: false
is: SBO:0000247
is: CHEBI:58297
initial amount: NaN
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
boundary condition: false
initial concentration: 1.0
name: Oxidized glutathione
type: Species
constant: false
is: HMDB03337

http://identifiers.org/biomodels.db/MODEL1310110049#_cab9b8f9_4fb8_48ad_9bdb_b70412126732
boundary condition: true
is encoded by: hsa:2954
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: GSTZ1
is: SBO:0000252

metaR r0642
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000000

metaM l2n2m2mn l
is: CHEBI:12936
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species

metaM arachdcrn m
constant: false
name: C20:4 carnitine
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57387
is: HMDB01322
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_bca43a00_08c6_448d_8b2e_924d2cb94611
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CH25H
is encoded by: hsa:9023
type: Species
is: O95992
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_8a0776d9_0ced_4e5a_a671_ad24ad3572a8
initial concentration: NaN
is encoded by: hsa:9152
name: SLC6A5
is: SBO:0000252
has only substance units: false
is: Q9Y345
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR G14T10g
reversible: false
fast: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR UDPGLCter
reactant: MODEL1310110049#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_bf48bad6_a77a_4cd5_9c90_af33806b29d6
is encoded by: hsa:9990
constant: false
name: SLC12A6
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9UHW9
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_757ebcc8_f0cd_4426_94e9_56a7e657316e
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: A6NED0
type: Species
is encoded by: hsa:2954
name: GSTZ1
has only substance units: false

metaM dadp n
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: dADP(3-)
type: Species
is: CHEBI:57667
constant: false
initial amount: NaN
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

http://identifiers.org/biomodels.db/MODEL1310110049#_53662209_a1a1_4a21_8896_77cdf17772f9
has only substance units: false
boundary condition: true
constant: false
is: A8K5Z0
initial concentration: NaN
is: SBO:0000252
name: B4GALT3
is encoded by: hsa:8703
initial amount: NaN
type: Species

metaR r2386
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_f4a7a4d0_93eb_422d_b47a_6dacf8001bf6
initial amount: NaN
is: Q8TE04
name: PANK1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:53354
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaR G5SDym
is described by: ECO:0000254
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.1.41
product: MODEL1310110049#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
name: glutamate-5-semialdehyde dehydrogenase (m)
modifier: MODEL1310110049#
reversible: false
type: Reaction

metaR r0553
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
fast: false
is described by: ECO:0000000
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is: SBO:0000176
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_c5428deb_52f8_4a4a_81df_b530d9a88653
is: SBO:0000252
is: O43451
has only substance units: false
constant: false
name: MGAM
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8972

metaM bildglcur e
type: Species
initial concentration: 1.0
constant: false
is: HMDB03325
boundary condition: false
is: CHEBI:58471
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_bdf8ad75_76f3_4094_bae2_608d2eeaf274
boundary condition: true
name: ALDH3B2
is: SBO:0000252
is: P48448
is encoded by: hsa:222
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_d8150168_d89a_4cdb_9fe1_cc18af697242
type: Species
constant: false
is encoded by: hsa:123041
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC24A4
is: Q8NFF2

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR 5MTHFt
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reversible: true

metaR r2389
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_8c6b8695_3586_420c_bc98_55153e94dc73
is: SBO:0000252
type: Species
is: P19367
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:3098
boundary condition: true
name: HK1

metaR MG1er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.106

http://identifiers.org/biomodels.db/MODEL1310110049#_9e7f67f6_9bf8_44a5_9037_cde66e4301b0
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6560
is: F5H066
name: SLC12A4
initial concentration: NaN
boundary condition: true
type: Species

metaM 5aizc c
constant: false
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
initial concentration: 1.0
is: HMDB06273
is: C04751
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58564

http://identifiers.org/biomodels.db/MODEL1310110049#_530dea05_7e7d_41ee_b021_ed7fb9819a14
has only substance units: false
is encoded by: hsa:9245
is: O95395
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: GCNT3
is: SBO:0000252
type: Species

metaM ura c
initial amount: NaN
is: CHEBI:17568
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: C00106
type: Species
name: Uracil
boundary condition: false
is: HMDB00300
initial concentration: 1.0

metaM ksi pre5 g
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 5
is: CHEBI:28067
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C101H164N7O75SX CHARGE: -2

metaM cs c deg4 l
constant: false
is: HMDB00812
initial amount: NaN
has only substance units: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 4
is: SBO:0000247
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
boundary condition: false
is: CHEBI:16953

metaM chlstol r
is: CHEBI:16290
boundary condition: false
is: HMDB06842
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: 5alpha-cholesta-7,24-dien-3beta-ol

metaR CRNtx
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
name: carnitine transport peroxisome to mitochondria

http://identifiers.org/biomodels.db/MODEL1310110049#_7ab576ae_6411_4413_9279_5cf055688a05
initial amount: NaN
boundary condition: true
is encoded by: hsa:5052
has only substance units: false
constant: false
name: PRDX1
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_cbcc62f7_0a2c_46d9_a548_6de4046a39ef
is: SBO:0000252
constant: false
name: STS
boundary condition: true
type: Species
initial concentration: NaN
is: P08842
is encoded by: hsa:412
initial amount: NaN
has only substance units: false

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
reversible: false
product: MODEL1310110049#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9de8c606_8b30_4c9c_be70_3ae80f821eb9
type: Species
is: Q9BX95
name: SGPP1
is encoded by: hsa:81537
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

metaM ibcoa m
constant: false
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: SBO:0000247
is: HMDB01243
initial amount: NaN
name: isobutyryl-CoA(4-)
has only substance units: false
is: CHEBI:57338
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_d312db78_8941_4b0f_bf70_484dd7aeb6c8
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: _AI684467_1_m
initial concentration: NaN
constant: false
is encoded by: hsa:AI684467
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_ce1c7b28_21b1_4f92_88e3_cc048aa0393d
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: PC
is: SBO:0000252
is: P11498
initial amount: NaN
is encoded by: hsa:5091

metaM ksi deg32 l
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 32
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
constant: false
is: HMDB00143
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:12936

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0944
modifier: MODEL1310110049#
is described by: ECO:0000000

metaR r0556
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110049#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaR CMPACNAtg
reversible: true
modifier: MODEL1310110049#
name: CMP-Sia Golgi transport via CMP antiport
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000269
product: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_5075a4d5_cc41_4795_b24c_4f118e395f82
name: ACLY
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: P53396
boundary condition: true
is encoded by: hsa:47

metaR KSII CORE2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110049#
name: keratan sulfate II (core2) transport, golgi to extracellular
fast: false
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
is: SBO:0000185

metaR CSNATer
is: SBO:0000176
name: carnitine O-acetyltransferase, endolasmic reticulum
is described by: ECO:0000254
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61648
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: Type IIIAb

http://identifiers.org/biomodels.db/MODEL1310110049#_fb07f0cc_ad4c_4eef_ad8e_23110af26a1c
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:92483
constant: false
name: LDHAL6B
boundary condition: true
is: Q9BYZ2
is: SBO:0000252

metaM ura e
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17568
name: uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
has only substance units: false
is: HMDB00300
boundary condition: false
initial amount: NaN

metaM fald c
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:16842
is: HMDB01426
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

metaR r0557
modifier: MODEL1310110049#
reversible: false
is described by: ECO:0000000
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
is: SBO:0000176
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_bb9c583b_7889_419b_a6f2_672863ea60d3
has only substance units: false
is: A8K7J7
is: SBO:0000252
is encoded by: hsa:3098
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: HK1
type: Species

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_f9a04ad6_5df9_4322_aa4f_d462fdcd3b38
is encoded by: hsa:9963
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: SLC23A1
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r0636
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110049#
is: SBO:0000176
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137

metaM CE5786 e
boundary condition: false
initial concentration: 1.0
is: CHEBI:27485
type: Species
has only substance units: false
name: kinetensin
constant: false
is: SBO:0000247
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
is: HMDB02710

metaM man c
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
name: D-Mannose
constant: false
initial concentration: 1.0
type: Species
is: HMDB00169
initial amount: NaN
is: CHEBI:16024

metaR O2St
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: superoxide anion transport via diffusion (extracellular)
type: Reaction

metaR GAO2g
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
name: Ganglioside O-acetylation
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
modifier: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: false
is described by: ECO:0000269

metaM na1 r
type: Species
name: sodium(1+)
is: CHEBI:29101
has only substance units: false
constant: false
boundary condition: false
is: HMDB00588
initial amount: NaN
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial concentration: 1.0

metaM ksi pre11 g
name: keratan sulfate I biosynthesis, precursor 11
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
type: Species
boundary condition: false

metaR r0547
kinetic law: MODEL1310110049#
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
modifier: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
product: MODEL1310110049#
is: SBO:0000176
reversible: true
reactant: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4

metaM HC01399 m
is: CHEBI:27466
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA

metaM arachdcrn r
is: SBO:0000247
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB06523
is: CHEBI:57368
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_3b6e64f7_aed9_46a6_a559_85f641cad8a4
name: ACOT2
is: P49753
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:10965
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM ksi pre12 g
constant: false
name: keratan sulfate I biosynthesis, precursor 12
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: HMDB00175
is: C00130
initial amount: NaN
is: CHEBI:58053
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_d61cf091_5962_485b_b82a_3403bffb1a49
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: ACSL1
is: SBO:0000252
is: P33121
initial amount: NaN
is encoded by: hsa:2180
constant: false

metaM gthox m
type: Species
initial amount: NaN
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58297
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_6ece88c2_71a6_4186_9049_b297ae562e07
name: PDE2A
is: Q8IW54
is encoded by: hsa:5138
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_f18386e0_54bc_4e22_8a44_2a4abe9a5240
is: SBO:0000252
type: Species
constant: false
name: ATP2B4
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:493
is: P23634

metaM cyan e
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
has only substance units: false
constant: false
is: CHEBI:18407
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: hydrogen cyanide
is: HMDB02084
initial concentration: 1.0

metaM dcacoa x
is: HMDB06404
boundary condition: false
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
is: SBO:0000247
type: Species
is: CHEBI:61430
initial concentration: 1.0
constant: false
has only substance units: false
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274

metaM sucsal m
is: CHEBI:57706
initial concentration: 1.0
is: HMDB01259
has only substance units: false
constant: false
boundary condition: false
name: Succinic semialdehyde
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
type: Species
initial amount: NaN
is: SBO:0000247

metaR SUCOAS1m
reversible: true
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is described by: ECO:0000000
name: Succinate--CoA ligase (GDP-forming)
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
fast: false

metaR r0638
reactant: MODEL1310110049#
reversible: true
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.2

http://identifiers.org/biomodels.db/MODEL1310110049#_2257efe2_09be_461b_844e_a214bce96c0a
name: MECR
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51102
type: Species
is: Q9BV79
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM doldp L r
is: CHEBI:15750
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: Dolichol diphosphate, human liver homolog
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_48d0577a_67a6_4571_96dc_1a2d0283a76d
type: Species
is encoded by: hsa:4513
is encoded by: hsa:1327
is encoded by: hsa:9167
has part: Q53XN1
has part: P24310
has part: Q6YFQ2
is: SBO:0000297
is encoded by: hsa:1351
has part: P24311
has part: Q8TF08
is encoded by: hsa:1337
has part: Q7GXZ8
has only substance units: false
is encoded by: hsa:125965
is encoded by: hsa:1329
has part: P13073
initial amount: NaN
boundary condition: true
is encoded by: hsa:4514
has part: Q6FGA0
has part: P14854
has part: P00414
is encoded by: hsa:1345
has part: P12074
has part: Q96KJ9
is encoded by: hsa:341947
is encoded by: hsa:170712
is encoded by: hsa:9377
has part: Q53YB7
is encoded by: hsa:1349
is encoded by: hsa:1339
has part: Q02221
has part: H0UI06
is encoded by: hsa:1346
has part: P09669
constant: false
initial concentration: NaN
has part: Q7Z4L0
is encoded by: hsa:4512
has part: P15954
is encoded by: hsa:1340
has part: Q7GXY8
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1350
has part: P20674
is encoded by: hsa:1347
is encoded by: hsa:84701

metaR CHSTEROLtrc
is described by: ECO:0000134
fast: false
is: SBO:0000185
type: Reaction
name: transport of cholesterol into the cytosol
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.

metaR RE3218C
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.2
fast: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is described by: ECO:0000000
modifier: MODEL1310110049#
name: RE3218

metaR r0549
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.1.1.17
product: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/1.6.5.3

metaR B3GNT31g
product: MODEL1310110049#
is described by: ECO:0000269
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM ksi deg4 l
has only substance units: false
name: keratan sulfate I, degradation product 4
is: HMDB00868
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: CHEBI:57737
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_16389508_d62a_4a40_a81c_78ba8bf9735a
name: PKLR
is: P30613
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5313
is: SBO:0000252
constant: false

metaR TAGt
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: triacylglycerol transport
reversible: true
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000

metaR r0637
is: SBO:0000176
type: Reaction
product: MODEL1310110049#
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#

metaR SUCRe
is version of: http://identifiers.org/ec-code/3.2.1.20
reversible: false
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
reactant: MODEL1310110049#
name: sucrose hydrolyzing enxyme, extracellular
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.10
is described by: ECO:0000269

metaR DTTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
name: dTTP diffusion in nucleus
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110049#

metaM HC01609 e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: SBO:0000247
constant: false
is: CHEBI:28766
has only substance units: false
initial amount: NaN
name: UroporphyrinogenI
type: Species

metaM cyan c
boundary condition: false
constant: false
is: CHEBI:18407
type: Species
initial amount: NaN
name: hydrogen cyanide
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
is: HMDB02084
has only substance units: false

metaM tag hs e
name: triglyceride
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:17855
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_28829bc7_fa06_4eed_aa75_358c110d25ab
is: SBO:0000252
is: E9KL44
constant: false
name: HADHA
type: Species
initial amount: NaN
is encoded by: hsa:3030
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM dgdp m
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00960
name: dGDP(2-)
is: CHEBI:58595

metaM pi e
boundary condition: false
initial amount: NaN
is: C00009
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
initial concentration: 1.0
is: CHEBI:43474
is: HMDB00973
has only substance units: false

metaM HC02175 e
initial concentration: 1.0
name: caprate
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
boundary condition: false
is: CHEBI:27689
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR G14T11g
reactant: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR MMEm
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.1.99.1
fast: false
modifier: MODEL1310110049#
reversible: true
name: methylmalonyl-CoA epimerase/racemase
kinetic law: MODEL1310110049#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
reactant: MODEL1310110049#

metaM man g
initial concentration: 1.0
is: CHEBI:16024
is: HMDB00169
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
boundary condition: false
type: Species
name: D-mannose
has only substance units: false

metaM chol e
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00114
is: HMDB00097
has only substance units: false
is: CHEBI:15354
name: Choline
initial amount: NaN

metaR MALSO4tm
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:sulfate antiport, mitochondrial
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269

metaM m1mpdol L c
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
type: Species

metaR GALASE5ly
modifier: MODEL1310110049#
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR RE2972M
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
kinetic law: MODEL1310110049#
name: RE2972
modifier: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.67

http://identifiers.org/biomodels.db/MODEL1310110049#_c4fb4cba_58d0_49c3_8acd_51265307f988
boundary condition: true
constant: false
is: SBO:0000252
name: _AI653169_1_c
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI653169

metaM ps hs m
has only substance units: false
constant: false
name: ps_hs[m]
boundary condition: false
is: CHEBI:18303
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0

metaM dgdp n
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
name: dGDP(2-)
boundary condition: false
has only substance units: false
is: HMDB00960
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaR BILGLCURtr
product: MODEL1310110049#
type: Reaction
name: glucuronidated compound transport
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is described by: ECO:0000000
reversible: true

metaR ACITL
reversible: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.3.8
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is: SBO:0000176
type: Reaction
name: ATP-Citrate lyase

http://identifiers.org/biomodels.db/MODEL1310110049#_023b5d39_4db2_4e3c_9216_db72fe7aacc5
is: SBO:0000252
constant: false
name: NDUFB10
type: Species
has only substance units: false
is encoded by: hsa:4716
initial amount: NaN
boundary condition: true
is: A8K761
initial concentration: NaN

metaM acngalgbside hs g
is: HMDB03406
constant: false
name: sialyl galactosylgloboside
initial amount: NaN
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16523
boundary condition: false
has only substance units: false

metaM ascb L e
constant: false
name: L-ascorbate
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:38290
is: HMDB00044
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_37aff8f2_1d18_4d90_83f9_bb2617b24d29
name: _AI656480_1_m
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI656480
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaR G16MT L
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110049#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
kinetic law: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000

metaM tag hs c
constant: false
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17855
type: Species
name: triglyceride

metaM HC02175 c
is: SBO:0000247
has only substance units: false
is: CHEBI:27689
name: caprate
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_ad4f2bed_95a6_49df_a378_b7478bda8faf
boundary condition: true
name: PPCS
initial amount: NaN
is: Q9HAB8
initial concentration: NaN
is encoded by: hsa:79717
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaM pi g
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
is: CHEBI:43474
name: hydrogenphosphate
initial concentration: 1.0

metaR CO2t
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
name: CO2 transporter via diffusion
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_5945b96f_7fdd_4d3b_aaf2_104988a98859
name: LGSN
initial amount: NaN
is: Q5TDP6
is encoded by: hsa:51557
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM na1 x
initial concentration: 1.0
is: SBO:0000247
name: sodium(1+)
is: CHEBI:29101
type: Species
has only substance units: false
constant: false
boundary condition: false
is: HMDB00588
initial amount: NaN
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330

metaR r0634
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaR r0339
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110049#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.2.22
product: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

metaM man e
name: D-Mannose
initial concentration: 1.0
is: C00159
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_38897691_20f9_4eaa_a29f_8b6693a79ef4
constant: false
is: Q9UBF8
has only substance units: false
boundary condition: true
is encoded by: hsa:5298
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: PI4KB

metaM ascb L c
boundary condition: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
has only substance units: false
initial amount: NaN
is: HMDB00044
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:38290
name: L-ascorbate
constant: false

metaM arachdcrn x
initial amount: NaN
constant: false
is: SBO:0000247
name: C20:4 carnitine
is: HMDB06523
type: Species
has only substance units: false
is: CHEBI:57368
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0
boundary condition: false

metaR r2048
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110049#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM pcrn x
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00824
initial concentration: 1.0
initial amount: NaN
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738

metaR N4Tg
reactant: MODEL1310110049#
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
type: Reaction
reversible: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#

metaM ksii core4 pre1 g
constant: false
is: CHEBI:28067
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C36H60N3O25X CHARGE: 0
has only substance units: false
initial amount: NaN
type: Species
name: keratan sulfate II biosynthesis, precursor 1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d8e1151f_3aa6_43c7_9914_0e3e297f85c8
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _642502_1_c
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:642502
constant: false

metaR P450SCC1m
fast: false
is: SBO:0000176
name: cholesterol monooxygenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
product: MODEL1310110049#
is described by: ECO:0000134

metaM C05957 r
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: SBO:0000247
constant: false
name: Prostaglandin J2
type: Species
initial concentration: 1.0
is: CHEBI:27485
is: HMDB02710

metaR r0633
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176
product: MODEL1310110049#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110049#
fast: false
reversible: true

metaR PCRNtm
reversible: false
name: transport into the mitochondria from cytosol (carnitine)
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
reactant: MODEL1310110049#

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR NDPK6n
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
modifier: MODEL1310110049#
is: SBO:0000176
fast: false
product: MODEL1310110049#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_ecf0cab1_a882_47eb_aff6_925c281fd145
is: SBO:0000252
has only substance units: false
type: Species
name: SLC34A2
initial amount: NaN
is: O95436
is encoded by: hsa:10568
constant: false
boundary condition: true
initial concentration: NaN

metaM man l
initial concentration: 1.0
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
has only substance units: false
initial amount: NaN
name: D-mannose
constant: false
is: SBO:0000247
is: CHEBI:16024
type: Species

metaR NDPK6m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
modifier: MODEL1310110049#
type: Reaction
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110049#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial

metaM HC02210 c
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
name: prostaglandin-d3
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:34939

metaM ksi deg23 l
is: CHEBI:12936
type: Species
is: HMDB00143
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 23
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
initial concentration: 1.0
boundary condition: false

metaM glyc3p c
is: CHEBI:57597
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00126
type: Species
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
initial amount: NaN
is: C00093
name: Glycerol 3-phosphate

metaM pcrn m
is: http://identifiers.org/pubchem.compound/107738
initial amount: NaN
is: HMDB00824
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaM chol c
has only substance units: false
initial concentration: 1.0
is: CHEBI:15354
is: C00114
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
type: Species
constant: false
is: HMDB00097
name: Choline
boundary condition: false

metaR BTNt4i
reactant: MODEL1310110049#
name: Biotin uptake (antiport)
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
fast: false
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_e0df4b73_06bc_4fa3_a379_74ef4ed0b72a
is encoded by: hsa:518
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is: SBO:0000297

metaM ps hs e
constant: false
is: SBO:0000247
is: CHEBI:18303
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: phosphatidylserine
has only substance units: false

metaR r0129
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
product: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_d62da9c9_708e_4a59_9caf_635589647f75
name: INPP4B
type: Species
initial concentration: NaN
is: O15327
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:8821

metaR r2043
modifier: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false

metaM pi c
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2
initial concentration: 1.0
boundary condition: false
is: C00009
constant: false
is: SBO:0000247
is: CHEBI:43474
type: Species
is: HMDB00973
initial amount: NaN
name: hydrogenphosphate

metaM dopa e
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
is: CHEBI:59905
is: SBO:0000247
is: HMDB00073
initial amount: NaN

metaM dgdp c
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
name: dGDP
is: CHEBI:58595
constant: false
is: C00361
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00960

metaM dcmp c
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: dCMP
is: HMDB01202
boundary condition: false
is: SBO:0000247
is: CHEBI:57566
has only substance units: false
is: C00239
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

http://identifiers.org/biomodels.db/MODEL1310110049#_9f0f3677_3a41_4b5d_bf6c_3f84f0500fd4
has only substance units: false
is encoded by: hsa:AI469183
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: _AI469183_1_x
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_99dbe26b_1609_4180_832a_a1444f42a118
constant: false
initial amount: NaN
type: Species
name: CLC
is encoded by: hsa:1178
boundary condition: true
has only substance units: false
initial concentration: NaN
is: C5HZ13
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_42f58743_8756_4bdb_95e7_229b30f5ad60
type: Species
is: P33316
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: DUT
is encoded by: hsa:1854
initial concentration: NaN

metaR FOLt2le
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110049#
is: SBO:0000185
name: folate transport via anion exchange
product: MODEL1310110049#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110049#

metaM cholcoa c
has only substance units: false
type: Species
is: CHEBI:57373
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01374
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)

metaM HC01115 c
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: NeuNGc
initial concentration: 1.0
is: CHEBI:29025

http://identifiers.org/biomodels.db/MODEL1310110049#_6e57a241_f786_4910_9736_bb8ab77743d2
initial concentration: NaN
name: ASRGL1
constant: false
boundary condition: true
is encoded by: hsa:80150
has only substance units: false
is: Q7L266
type: Species
is: SBO:0000252
initial amount: NaN

metaR OROTGLUt
reversible: true
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: OROTGLUt
is described by: ECO:0000134
reactant: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
type: Reaction

metaR 34DHXMANDACOX
reactant: MODEL1310110049#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB

metaM ps hs c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
constant: false
is: CHEBI:18303
initial concentration: 1.0
name: ps_hs[c]
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5b7d910f_e899_4045_86ad_2376830cc613
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: MDH2
is: P40926
is encoded by: hsa:4191
is: SBO:0000252
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_8364cc2f_80da_4eea_a30f_eade61cb4c95
is: O15056
has only substance units: false
type: Species
is encoded by: hsa:8871
boundary condition: true
is: SBO:0000252
name: SYNJ2
initial concentration: NaN
initial amount: NaN
constant: false

metaM dcacoa m
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
constant: false
initial concentration: 1.0
is: C05274
is: HMDB06404
has only substance units: false
is: CHEBI:61430
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species

metaR SCPx
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110049#
type: Reaction
name: peroxisomal thiolase 2
modifier: MODEL1310110049#
reversible: false
is described by: ECO:0000269
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is: SBO:0000176
fast: false
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_da3a06fb_d192_41c7_99c6_7f7bc5929f5b
is: F8WDN9
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:27068
has only substance units: false
name: PPA2
boundary condition: true
initial amount: NaN

metaR AKR1D2
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_378b42df_5db7_43a9_920b_14c646666741
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:26330
constant: false
is: SBO:0000252
name: GAPDHS
initial concentration: NaN
is: O14556
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_da9d0b0c_83a7_4096_951e_6550b44850d5
boundary condition: true
is encoded by: hsa:29920
is: Q96C36
initial amount: NaN
name: PYCR2
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_e8743d75_bc56_4ff4_9f5e_132bc759b7d6
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ACAT2
boundary condition: true
is: Q9BWD1
type: Species
is encoded by: hsa:39
constant: false

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

metaR S6T9g
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110049#
type: Reaction

metaR RE1903R
reactant: MODEL1310110049#
name: RE1903
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
fast: false
product: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_63c27f5d_6afe_4c6f_ad64_dec2a79008b6
is encoded by: hsa:BE042354
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _BE042354_1_m
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaR AMANK
fast: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
kinetic law: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.59
is version of: http://identifiers.org/ec-code/5.1.3.14
name: N-acetyl-D-mannosamine kinase
product: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#

metaR RE3627M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
type: Reaction
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#
modifier: MODEL1310110049#
name: RE3627

metaR r0639
product: MODEL1310110049#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110049#_791fdd2e_99be_45da_ab28_8cc05cf77b78
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3242
name: HPD
is: SBO:0000252
type: Species
initial concentration: NaN
is: B3KQ63

metaM gdpfuc g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: HMDB01095
is: CHEBI:57984
constant: false
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247

metaR CLPNDt
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
name: fatty acid transport via diffusion
product: MODEL1310110049#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_8635426e_9649_45bd_860d_5a000956c651
initial concentration: NaN
constant: false
has only substance units: false
is: H7C5B8
boundary condition: true
is encoded by: hsa:4708
type: Species
initial amount: NaN
name: NDUFB2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_f6f48c78_3bb1_4575_8fab_327231fc890d
has only substance units: false
is encoded by: hsa:10723
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC12A7
type: Species
initial amount: NaN
is: Q9Y666

metaR AG13T16g
modifier: MODEL1310110049#
fast: false
is: SBO:0000176
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_96b0dd68_14d1_46ca_b2f4_084d14e67868
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10559
has only substance units: false
type: Species
name: SLC35A1
constant: false
is: P78382
boundary condition: true

metaR r1374
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
name: EC:3.2.1.14
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#

metaR UDPtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
is described by: ECO:0000000
type: Reaction
reversible: true
name: udp intracellular transport
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_1f4642b3_c87f_4588_b2d8_f7f89bb09ea3
type: Species
name: ITPKB
constant: false
initial amount: NaN
is encoded by: hsa:3707
has only substance units: false
is: P27987
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR FAOXC204
product: MODEL1310110049#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110049#

metaR PROD2m
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.5.99.8
reversible: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
name: Proline dehydrogenase (m)
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110049#
fast: false

metaR ENGASEly
fast: false
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9c14a43b_1184_43de_baca_d6dea992bb55
is encoded by: hsa:9962
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: SLC23A2
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9UGH3

metaR ILEtec
kinetic law: MODEL1310110049#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110049#
is described by: ECO:0000269
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110049#
reversible: true
name: L-isoleucine transport via diffusion (extracellular to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110049#_61a36f50_4ef8_49a9_803e_045e6dfb8756
initial concentration: NaN
type: Species
is: Q6IB54
name: ATP5J
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:522

metaR DALAt2r
name: D-alanine transport via proton symport
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false

metaM ksii core2 pre4 g
is: C00130
type: Species
initial concentration: 1.0
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4
notes: FORMULA: C53H86N4O38X CHARGE: -1
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_5fcc5c6a_d82a_4c6f_a95f_a15ce91bc4d5
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: SLC17A2
is encoded by: hsa:10246
is: O00624

http://identifiers.org/biomodels.db/MODEL1310110049#_d9276234_c176_4c81_90af_2998849d485f
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: P54803
is encoded by: hsa:2581
name: GALC
initial concentration: NaN

metaM ocdcea r
constant: false
boundary condition: false
name: octadecenoate (n-C18:1)
has only substance units: false
is: HMDB00207
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:0
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
initial concentration: 1.0

metaM em2emgacpail prot hs r
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:16870
initial amount: NaN
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
boundary condition: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
initial concentration: 1.0
is: HMDB00086

metaR GALSGLT1le
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_3c0b3fb9_30c6_43ff_aa3f_3706a66b8446
initial concentration: NaN
name: GCNT4
constant: false
is encoded by: hsa:51301
is: Q9P109
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR r1375
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_a221ab01_ccc3_4b21_8560_12087940c3d8
is: Q9P1E4
boundary condition: true
constant: false
name: MAN2A2
is encoded by: hsa:4122
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaR G14T7g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#

metaR RE3004M
name: RE3004
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reversible: true
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR AG13T12g
fast: false
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110049#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110049#
reversible: false

metaM m8mpdol U r
initial amount: NaN
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:59093
has only substance units: false
constant: false
is: SBO:0000247
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR HSD17B4x
reversible: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
reactant: MODEL1310110049#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
name: hydroxysteroid (17-beta) dehydrogenase 4
product: MODEL1310110049#

metaM g2m8mpdol U r
constant: false
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
is: CHEBI:59093
type: Species
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR TYRTA
modifier: MODEL1310110049#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
name: tyrosine transaminase
is: SBO:0000176
reactant: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110049#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_a9839eb7_98b1_46c4_a672_4aa350269134
initial amount: NaN
is encoded by: hsa:954
type: Species
initial concentration: NaN
is: Q5SPY7
name: ENTPD2
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR FTHFL
kinetic law: MODEL1310110049#
name: Formate-tetrahydrofolate ligase
modifier: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
is described by: ECO:0000134
reversible: true

metaM dtdp n
boundary condition: false
is: HMDB01274
type: Species
is: CHEBI:58369
initial amount: NaN
constant: false
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
is: SBO:0000247

metaM nh4 e
is: CHEBI:28938
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: ammonium
constant: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_86e6440a_ee94_402b_ba7f_7eb44877a21e
is: Q7LGC8
initial amount: NaN
is encoded by: hsa:9469
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: CHST3
boundary condition: true

metaR r2202
reversible: true
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
product: MODEL1310110049#
fast: false

metaM HC00319 m
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: Malonate
initial amount: NaN
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
initial concentration: 1.0
boundary condition: false

metaM dump c
constant: false
initial amount: NaN
boundary condition: false
is: C00365
name: dUMP
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
is: HMDB01409
initial concentration: 1.0
is: CHEBI:246422

http://identifiers.org/biomodels.db/MODEL1310110049#_0b845065_6ba7_4a95_a1a5_906fe766e335
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:55350
name: VNN3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM for r
is: SBO:0000247
is: C00058
is: HMDB00142
type: Species
name: Formate
constant: false
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:15740

http://identifiers.org/biomodels.db/MODEL1310110049#_c0a1749f_9150_40a6_bc10_6e21c30b2b40
constant: false
initial concentration: NaN
name: MYO5B
is encoded by: hsa:4645
initial amount: NaN
type: Species
is: Q9H6Y6
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR AHCYStr
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
is: SBO:0000185
fast: false
name: S-Adenosyl-L-homocysteine intracellular diffusion
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#

metaM acgam c
is: HMDB00215
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
initial concentration: 1.0
is: CHEBI:17411

metaR r0787
is described by: ECO:0000000
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
product: MODEL1310110049#
is: SBO:0000176
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
fast: false
reversible: false

metaR r2201
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110049#

metaR CYSALANaEx
reversible: false
kinetic law: MODEL1310110049#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is described by: ECO:0000269

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR NDPK3n
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
type: Reaction
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#

metaM retfa c
has only substance units: false
is: CHEBI:50211
is: HMDB00305
boundary condition: false
name: fatty acid retinol
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0

metaM gam e
is: CHEBI:17315
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
is: C00329
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01514
initial amount: NaN

metaM lys L m
constant: false
type: Species
boundary condition: false
name: L-lysinium(1+)
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
initial concentration: 1.0
is: SBO:0000247
is: HMDB00182

http://identifiers.org/biomodels.db/MODEL1310110049#_ed96fcf0_2a43_44df_a6f4_0718bf3bb275
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: HMGCS1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3157
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_a6fb4c7b_1593_42da_893c_3f4640f672dc
is encoded by: hsa:6715
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: P18405
boundary condition: true
name: SRD5A1
type: Species

metaR r0784
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
fast: false

metaR ACACT1x
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
kinetic law: MODEL1310110049#
is: SBO:0000176
fast: false
product: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial

metaR NACHEXA22ly
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR S23T3g
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.6
is described by: ECO:0000000
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is: SBO:0000176
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction

metaR CYSSERNaEx
kinetic law: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
reversible: false
reactant: MODEL1310110049#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110049#

metaR r2200
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
reversible: true

metaR r0998
reactant: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
product: MODEL1310110049#
fast: false

metaM ha e
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336
initial concentration: 1.0
name: hyaluronan
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_b5dd0ee7_a743_496b_b9ad_9b127f507d30
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: ST3GAL3
is: Q11203
has only substance units: false
initial amount: NaN
is encoded by: hsa:6487

metaR r0208
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.4.1.1
is: SBO:0000176
fast: false
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
kinetic law: MODEL1310110049#

metaM dtdp m
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
name: dTDP
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: C00363

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is described by: ECO:0000304
fast: false
is: SBO:0000176

metaM thymd c
is: SBO:0000247
name: Thymidine
initial amount: NaN
has only substance units: false
is: CHEBI:17748
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00273
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
constant: false
is: C00214

metaM mescoa m
has only substance units: false
is: C06028
type: Species
name: Mesaconyl-CoA
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27969
boundary condition: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_c69a6027_2e18_4484_81d4_ece6fc1e8822
is encoded by: hsa:5538
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PPT1
is: Q6FGQ4
constant: false
initial concentration: NaN

metaR RE0958E
kinetic law: MODEL1310110049#
name: RE0958
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
product: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_dfd27743_f030_4dcf_afbd_416a515f1771
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: Q16836
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3033
name: HADH
initial amount: NaN

metaM HC01415 m
name: (2E)-Octenoyl-CoA
constant: false
initial concentration: 1.0
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
is: CHEBI:27537
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM HC00822 e
is: CHEBI:28681
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: Chitobiose
initial concentration: 1.0
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_3b1fed28_e6e7_4b71_b986_0f208000b02f
boundary condition: true
is: SBO:0000252
name: PIGX
is: Q8TBF5
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54965

metaR r0999
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110049#
name: Facilitated diffusion
reactant: MODEL1310110049#

metaR GALASE4ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
name: beta-galactosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reactant: MODEL1310110049#

metaM gam c
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
is: CHEBI:17315
has only substance units: false
initial concentration: 1.0
type: Species
is: C00329
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01514
initial amount: NaN

metaM galgluside hs c
type: Species
constant: false
name: galactosyl glucosyl ceramide
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB06535
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
has only substance units: false

metaR RE1796M
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
reversible: true
name: RE1796
kinetic law: MODEL1310110049#

metaR r0782
is described by: ECO:0000000
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
type: Reaction
reversible: false
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
kinetic law: MODEL1310110049#
fast: false

metaR RE1519M
is described by: ECO:0000000
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
reversible: true
type: Reaction
name: RE1519
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaR ACACT1r
modifier: MODEL1310110049#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: acetyl-CoA C-acetyltransferase

metaR ADAe
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reversible: false
is: SBO:0000176
product: MODEL1310110049#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: Adenosine deaminase, extracellular
is version of: http://identifiers.org/ec-code/3.5.4.4

http://identifiers.org/biomodels.db/MODEL1310110049#_b9381f4a_1fc2_41ab_b28c_e6700c1353ab
name: ENTPD4
type: Species
constant: false
boundary condition: true
is encoded by: hsa:9583
is: Q9Y227
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
initial amount: NaN
initial concentration: 1.0
name: nLc7Cer
type: Species
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
is: CHEBI:26174
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaR INSTt2r
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
fast: false
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110049#
reactant: MODEL1310110049#
name: inositol transport in via proton symport
modifier: MODEL1310110049#
is described by: ECO:0000269

metaR PROt2r
is described by: ECO:0000304
modifier: MODEL1310110049#
type: Reaction
name: L-proline reversible transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_54b4f9a0_a703_40ac_a98c_9d016b4c426f
initial amount: NaN
type: Species
name: _AI971036_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AI971036
constant: false
initial concentration: NaN

metaR r2084
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110049#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_17780d65_7ce2_4d69_af0d_87e372e30971
type: Species
boundary condition: true
name: NDUFC1
is: O43677
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4717
initial amount: NaN

metaM dolmanp L c
type: Species
is: CHEBI:15809
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human liver homolog
initial amount: NaN
boundary condition: false

metaR r0997
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: COT Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
fast: false
product: MODEL1310110049#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110049#
type: Reaction
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_3ec23a1b_45b4_4ec6_ad82_c8ba9f60a8af
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI024818_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:AI024818
boundary condition: true

metaR APAT2rm
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: true
reactant: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110049#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)

metaM anth c
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
type: Species
name: anthranilate
is: HMDB01123
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:16567
initial amount: NaN

metaR r2083
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#
modifier: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR r0994
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#
is: SBO:0000185
name: Facilitated diffusion

metaR r2081
reversible: true
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_43d6c9f9_d4f7_44dc_a42c_0d3c1ba9721d
name: PLCB1
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:23236
type: Species
is: SBO:0000252

metaM acgbgbside hs c
name: beta GalNAc globoside
has only substance units: false
initial concentration: 1.0
is: HMDB00215
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
boundary condition: false
is: CHEBI:17411
type: Species
constant: false

metaR r1903
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
product: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR r0780
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176

metaR AG13T3g
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
modifier: MODEL1310110049#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000

metaR r1292
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#
name: Postulated transport reaction
type: Reaction
kinetic law: MODEL1310110049#

metaM 4hglusa m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: CHEBI:27809
name: L-4-hydroxyglutamic semialdehyde
type: Species
initial amount: NaN
constant: false
is: HMDB06556

http://identifiers.org/biomodels.db/MODEL1310110049#_38af8236_3c06_4b71_8960_1f725be697ee
initial amount: NaN
name: PLCD4
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9BRC7
is encoded by: hsa:84812
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_877cb528_e387_4db3_a5bf_91d8282caf2f
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:51227
is: SBO:0000252
has only substance units: false
is: P57054
initial amount: NaN
boundary condition: true
name: PIGP

http://identifiers.org/biomodels.db/MODEL1310110049#_b2e680c2_1152_4b66_9274_7dc7f79ae2cf
type: Species
is encoded by: hsa:2882
constant: false
name: GPX7
initial amount: NaN
has only substance units: false
is: Q96SL4
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_1dda329a_5cdd_4d4a_a7e7_f2f8a8c1f730
initial concentration: NaN
name: _NM_013421_1_m
type: Species
has only substance units: false
constant: false
is encoded by: hsa:NM 013421
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r2082
modifier: MODEL1310110049#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185

metaR r0781
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
type: Reaction
product: MODEL1310110049#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176

metaM fum c
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: HMDB00134
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Fumarate
is: SBO:0000247
type: Species
constant: false
is: CHEBI:29806
boundary condition: false
is: C00122

http://identifiers.org/biomodels.db/MODEL1310110049#_e77b6130_3822_46f2_9405_22418dde2a25
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _AA788780_1_c
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:AA788780

metaR r2080
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaR r0995
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110049#
type: Reaction

metaR DM T antigen g
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR MAL Ltx
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
fast: false
reversible: true
name: Transport reaction for malate
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185

metaM cholcoar x
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB02178
is: CHEBI:58677
is: SBO:0000247
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
constant: false

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_2db92c84_bb40_4808_bddc_84109fb6d9dc
boundary condition: true
is: SBO:0000252
name: SLC17A4
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: Q9Y2C5
has only substance units: false
is encoded by: hsa:10050

metaM hdca l
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00220
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate

metaR r1291
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
name: Postulated transport reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
type: Reaction
reversible: true

metaR KSII CORE4tly
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
product: MODEL1310110049#
is: SBO:0000185
reversible: false
type: Reaction

metaM n2m2nm l
is: HMDB01356
initial concentration: 1.0
is: CHEBI:57312
boundary condition: false
constant: false
name: n2m2nmasn (w/o peptide linkage)
notes: FORMULA: C58H97N5O41 CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species

metaM anth e
name: anthranilate
has only substance units: false
is: CHEBI:16567
type: Species
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: HMDB01123
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaR r0434
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: true
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#

metaM galgluside hs g
is: C00015
initial amount: NaN
type: Species
is: HMDB00295
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: CHEBI:58223
name: galactosyl glucosyl ceramide
has only substance units: false
is: SBO:0000247

metaM c12dccoa x
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
initial concentration: 1.0
name: dodecanedioylcoa
type: Species
constant: false
has only substance units: false
boundary condition: false
is: C14143
is: HMDB04047

http://identifiers.org/biomodels.db/MODEL1310110049#_b0713458_532b_4374_9d07_67727bf0493b
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ALDH1B1
type: Species
is: P30837
is encoded by: hsa:219
boundary condition: true
constant: false
is: SBO:0000252

metaR ALAGLNexR
reversible: true
modifier: MODEL1310110049#
product: MODEL1310110049#
fast: false
name: L-alanine/glutamine reversible exchange
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000304

metaM 34dhpac c
is: CHEBI:27978
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
name: 3,4-Dihydroxyphenylacetaldehyde
type: Species
is: HMDB03791
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR r1298
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000000
name: Vesicular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
reactant: MODEL1310110049#
is: SBO:0000185

metaR r2355
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110049#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#
type: Reaction

metaM strdnccoa m
constant: false
type: Species
name: stearidonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205473
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06519
is: C16163
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_095e164e_7b41_46df_bd5a_3f44b8989454
constant: false
name: UGCG
is: SBO:0000252
is: Q16739
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:7357
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_3e19ea21_4bb8_4c06_b390_7262d4c65344
constant: false
is encoded by: hsa:AF116616
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _AF116616_1_m
type: Species

metaM lys L c
is: CHEBI:32551
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: L-lysinium(1+)

metaM hdca c
name: palmitate
constant: false
is: SBO:0000247
is: CHEBI:7896
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220

http://identifiers.org/biomodels.db/MODEL1310110049#_6d6e253f_010d_40bb_90ef_fc5b186a7a8a
initial amount: NaN
boundary condition: true
is: P31040
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:6389
name: SDHA
type: Species

metaM 34hpp c
has only substance units: false
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
type: Species
is: SBO:0000247
constant: false
is: HMDB00707
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
boundary condition: false
initial amount: NaN

metaM nh4 m
is: HMDB00051
initial concentration: 1.0
name: Ammonium
is: CHEBI:28938
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_3b26fba7_43d8_4786_835f_61a280c4c8dc
initial concentration: NaN
initial amount: NaN
name: _AL050025_1_c
type: Species
boundary condition: true
constant: false
is encoded by: hsa:AL050025
is: SBO:0000252
has only substance units: false

metaM m2mpdol U c
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
is: CHEBI:28049
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
constant: false
is: SBO:0000247
type: Species

metaR r2354
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#
type: Reaction
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110049#_16f42d17_05dc_4b4e_b4f2_7dae602af394
boundary condition: true
is: SBO:0000252
name: SLC20A1
is encoded by: hsa:6574
is: Q8WUM9
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaR r0545
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
product: MODEL1310110049#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_0387f60a_57d0_4c60_b036_03338722a7f9
name: SLC12A5
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
is: Q9H2X9
initial concentration: NaN
is encoded by: hsa:57468
initial amount: NaN

metaM ksi pre1 g
has only substance units: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
name: keratan sulfate I biosynthesis, precursor 1
is: C00130
boundary condition: false
is: HMDB00175
is: CHEBI:58053
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

metaR THRGLNNaEx
fast: false
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)

http://identifiers.org/biomodels.db/MODEL1310110049#_70be58a1_7878_41a6_8dcb_3e35ee0da67a
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:2629
name: GBA
initial concentration: NaN
is: B7Z5G2
is: SBO:0000252
boundary condition: true

metaM CE1926 e
name: gama-carboxyethyl-hydroxychroman
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: SBO:0000247

metaM hexdiac r
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C08260
is: HMDB00672
boundary condition: false
name: hexadecanediocacid
notes: FORMULA: C16H28O4 CHARGE: -2

metaR FUT911g
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: Alpha-(1,3)-fucosyltransferase
modifier: MODEL1310110049#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.152

http://identifiers.org/biomodels.db/MODEL1310110049#_638ad03a_c246_46ec_a614_03c361f5dd2e
is: SBO:0000252
constant: false
is: Q02218
type: Species
boundary condition: true
name: OGDH
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4967

metaR r0840
type: Reaction
product: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Free diffusion
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.70

metaR ORNt4m
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
is described by: ECO:0000269
name: ornithine mitochondrial transport exchange with citruline
product: MODEL1310110049#
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#

metaM lys L e
is: CHEBI:32551
boundary condition: false
is: HMDB00182
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: L-lysinium(1+)

metaR LTC4CP
name: Leukotriene C4 carboxypeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false

metaM pep c
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: C00074
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial concentration: 1.0
is: CHEBI:18021
name: Phosphoenolpyruvate
is: HMDB00263

metaR r2353
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
type: Reaction
reversible: true

metaM nrpphr e
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
type: Species
is: SBO:0000247
is: CHEBI:33569
initial amount: NaN
name: Norepinephrine
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_718de0ea_a5e7_49a0_aba6_57746e5af55a
type: Species
constant: false
name: PLCG1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9UFY1
boundary condition: true
is encoded by: hsa:5335
initial concentration: NaN

metaM acgbgbside hs g
has only substance units: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
is: CHEBI:17411
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: beta GalNAc globoside
boundary condition: false
is: HMDB00215

http://identifiers.org/biomodels.db/MODEL1310110049#_794fe7c5_582c_41d2_9ae1_aaafc1bb2265
name: UGP2
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:7360
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

metaM urate e
initial amount: NaN
is: CHEBI:17775
is: SBO:0000247
boundary condition: false
name: Urate
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: C00366
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: HMDB00289

metaM chol n
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
initial concentration: 1.0
type: Species
name: choline
initial amount: NaN
is: CHEBI:15354
has only substance units: false

metaM ksii core2 pre7 g
initial amount: NaN
notes: FORMULA: C67H108N5O51SX CHARGE: -2
constant: false
initial concentration: 1.0
is: CHEBI:58053
type: Species
boundary condition: false
has only substance units: false
is: HMDB00175
is: SBO:0000247
is: C00130
name: keratan sulfate II biosynthesis, precursor 7

metaR NAtx
name: sodium transport via diffusion (perioxisome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: true
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_873a47f0_cf15_43e9_b1fa_af3fcf137c39
initial amount: NaN
type: Species
boundary condition: true
name: SLC27A1
is encoded by: hsa:376497
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaM nrpphr c
name: Norepinephrine
boundary condition: false
is: CHEBI:33569
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
constant: false
initial concentration: 1.0

metaM dtdp e
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
has only substance units: false
type: Species
is: CHEBI:58369
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_770c78be_f2d7_4df5_a423_c932f5cd960f
name: _FLJ44968_1_m
is encoded by: hsa:FLJ44968
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true

metaR r2352
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR H6ET3er
product: MODEL1310110049#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
fast: false
reactant: MODEL1310110049#

metaM nh4 n
is: SBO:0000247
boundary condition: false
is: HMDB00051
name: ammonium
has only substance units: false
is: CHEBI:28938
initial amount: NaN
constant: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
type: Species

metaM ha l
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
initial concentration: 1.0
name: hyaluronan
is: SBO:0000247
is: CHEBI:16336

metaM dump n
has only substance units: false
constant: false
is: SBO:0000247
name: dUMP(2-)
boundary condition: false
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
is: CHEBI:246422
initial amount: NaN
is: HMDB01409

metaM HC02208 c
is: SBO:0000247
boundary condition: false
name: prostaglandin-d1
constant: false
has only substance units: false
type: Species
is: CHEBI:27696
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
initial amount: NaN

metaR AICART
type: Reaction
is described by: ECO:0000269
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
modifier: MODEL1310110049#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.3

http://identifiers.org/biomodels.db/MODEL1310110049#_9ea9ee49_94fd_4c95_a652_91cbabc7166a
is encoded by: hsa:1629
name: DBT
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: P11182
boundary condition: true
is: SBO:0000252
type: Species

metaM glyb c
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
name: glycine betaine
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:17750
constant: false
initial concentration: 1.0
is: HMDB00043
is: SBO:0000247

metaR DASPO1p
reversible: false
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: D-aspartate oxidase, peroxisomal
is version of: http://identifiers.org/ec-code/1.4.3.1
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#

metaM Rtotal c
is: HMDB01448
initial amount: NaN
is: CHEBI:16189
type: Species
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR G5SADrm
fast: false
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reactant: MODEL1310110049#

metaM urate c
initial amount: NaN
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: C00366
is: SBO:0000247
is: CHEBI:17775
is: HMDB00289
has only substance units: false
name: Urate

metaR SUCCTD
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_b734d021_7457_4afa_9d3f_68f7f2918260
initial concentration: NaN
is encoded by: hsa:3098
type: Species
name: HK1
is: Q59FD4
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaM trp L c
type: Species
boundary condition: false
constant: false
is: HMDB00929
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:16828
name: L-tryptophan
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080

metaM dtdp c
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: C00363
initial concentration: 1.0
has only substance units: false
name: dTDP

metaR r0541
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
modifier: MODEL1310110049#
type: Reaction
reversible: true
kinetic law: MODEL1310110049#
is: SBO:0000176
fast: false
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7

metaM HC02208 e
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
is: CHEBI:27696
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: prostaglandin-d1

http://identifiers.org/biomodels.db/MODEL1310110049#_822c4ef6_874a_4910_bb68_80d3b908cb95
is: SBO:0000252
initial concentration: NaN
is: Q16881
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:7296
type: Species
boundary condition: true
name: TXNRD1

metaR r0630
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65

metaM acgbgbside hs l
is: CHEBI:17411
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: beta GalNAc globoside
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
has only substance units: false
is: HMDB00215
initial amount: NaN
boundary condition: false

metaM m2mn l
is: HMDB06537
constant: false
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_7ed26bad_0c3b_4239_b55e_9fe7f005ec3e
has only substance units: false
initial amount: NaN
name: PDE3A
is encoded by: hsa:5139
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q14432

metaR AHCYStd
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
fast: false
reversible: true
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
name: diffusion of S-Adenosyl-L-homocysteine

metaM hdca e
is: SBO:0000247
is: HMDB00220
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1
is: C00249
has only substance units: false
constant: false
boundary condition: false
type: Species
is: CHEBI:0
name: Hexadecanoate (n-C16:0)

metaR G13MT U
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.132
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_ea2f18a3_3849_4f18_803e_35b41912bd8f
is: Q9NY64
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLC2A8
is encoded by: hsa:29988
type: Species
constant: false
has only substance units: false

metaM Rtotal e
initial concentration: 1.0
is: HMDB00244
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
name: R total
is: C00255
has only substance units: false
is: CHEBI:3554
boundary condition: false
type: Species
constant: false

metaR r0841
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.271
modifier: MODEL1310110049#
name: Free diffusion
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_e364a8f0_915d_4539_ab2a_a44e7a81d151
name: _AI090874_1_c
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI090874
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_75b95c19_a9ef_470a_ac40_102541a36bab
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q8WXF9
type: Species
is encoded by: hsa:66035
is: SBO:0000252
initial amount: NaN
constant: false
name: SLC2A11

http://identifiers.org/biomodels.db/MODEL1310110049#_ef6f88d9_7a17_4642_8a5a_27a129cdab4c
is encoded by: hsa:158
initial amount: NaN
name: ADSL
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM trp L e
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00929
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16828
name: L-tryptophan
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_9e40501a_1062_4351_adeb_7bfa2f799be5
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:115286
boundary condition: true
name: SLC25A26
type: Species
is: F8WAB8
is: SBO:0000252

metaR RETH
kinetic law: MODEL1310110049#
is: SBO:0000176
name: retinyl ester hydrolase
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
type: Reaction
reactant: MODEL1310110049#
fast: false

metaR r1299
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
name: Vesicular transport
reversible: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_8f9b7b89_bc5f_4f61_9dbb_e765f817b9c0
is: SBO:0000252
is: A8K460
initial concentration: NaN
is encoded by: hsa:8398
name: PLA2G6
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR APOCFm
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#
fast: false
reversible: false
name: Apocarboxylase formation, mitochondrial
reactant: MODEL1310110049#
is described by: ECO:0000000

metaR r0842
type: Reaction
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.1.72
product: MODEL1310110049#
reversible: true
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_b4b8b6fd_0565_4827_b4a8_0a4942d714bd
name: HEXB
is: P07686
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3074
type: Species

metaR P45027A11m
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269
kinetic law: MODEL1310110049#
fast: false
reversible: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ

metaR r0317
fast: false
product: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
reactant: MODEL1310110049#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
modifier: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_1e3411c4_09f1_4b55_95a5_83eebe2d9b2a
has only substance units: false
is: Q6IBB5
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: NDUFA1
is encoded by: hsa:4694
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_83795873_9024_4b3e_9d9f_5a6196d80567
is: P49902
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:22978
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: NT5C2

metaM HC01377 m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
name: S-(3-Methylbutanoyl)-dihydrolipoamide
constant: false
has only substance units: false
type: Species
is: CHEBI:27462

metaM 13 cis retn c
type: Species
is: SBO:0000247
is: HMDB06219
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c055dd38_f95a_4c0c_83aa_06787915d839
name: _AA576959_1_c
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA576959
has only substance units: false
is: SBO:0000252
type: Species

metaM uacgam g
is: CHEBI:57705
boundary condition: false
has only substance units: false
is: HMDB00290
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_188bd227_618b_44af_b2e7_409333a28305
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR 5ADTSTSTERONEte
product: MODEL1310110049#
reversible: true
is: SBO:0000185
name: 5 alpha dihydrotesterone transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000

metaR P5CRm
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110049#
fast: false
reversible: false
name: pyrroline-5-carboxylate reductase (m)
product: MODEL1310110049#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_e7781533_b199_4e4b_b34e_00d14c6bcf63
constant: false
initial concentration: NaN
is encoded by: hsa:522
boundary condition: true
has only substance units: false
name: ATP5J
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_d34091b1_6ddb_4d53_bb46_eea0099f1bb0
initial concentration: NaN
initial amount: NaN
name: TXNRD1
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:7296
is: SBO:0000252

metaM dgmp m
is: C00362
has only substance units: false
is: SBO:0000247
is: CHEBI:57673
name: dGMP
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
boundary condition: false

metaR MM6bg
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

metaM CE2422 m
boundary condition: false
has only substance units: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:28387
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial amount: NaN
is: HMDB11123
constant: false

metaR r0539
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110049#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
modifier: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_81a3c802_2c6c_47be_8028_8cfc5543ed30
is: Q05C14
is encoded by: hsa:2352
initial concentration: NaN
name: FOLR3
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_bd546e1a_b43b_4a34_a5e4_4a5ddf861f97
name: NDUFB8
is: SBO:0000252
is encoded by: hsa:4714
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O95169
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ae999594_d37d_4cb2_bd24_aa813c45d070
is encoded by: hsa:AA532636
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: _AA532636_1_m
type: Species

metaM ksi pre29 g
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:28067
is: SBO:0000247
constant: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
name: keratan sulfate I biosynthesis, precursor 29

metaM s2l2n2m2mn l
type: Species
notes: FORMULA: C76H123N5O57 CHARGE: -2
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57312
has only substance units: false
is: SBO:0000247
is: HMDB01356

http://identifiers.org/biomodels.db/MODEL1310110049#_b0346e26_b2a8_463f_b2f1_37d43565e422
has only substance units: false
constant: false
boundary condition: true
is: O95497
is encoded by: hsa:8876
initial amount: NaN
name: VNN1
type: Species
initial concentration: NaN
is: SBO:0000252

metaM xan c
has only substance units: false
name: Xanthine
is: SBO:0000247
is: CHEBI:17712
is: C00385
is: HMDB00292
boundary condition: false
constant: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_663defa9_5361_471a_a8b9_debef4eb2feb
boundary condition: true
constant: false
is encoded by: hsa:883
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: CCBL1
is: Q16773
initial amount: NaN

metaR DAGK hs
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM f1a l
initial amount: NaN
name: F1alpha
has only substance units: false
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15936
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_81a162a4_695f_486a_888c_6c9de53ef140
has only substance units: false
is encoded by: hsa:211
initial amount: NaN
name: ALAS1
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: Q5JAM2

metaM cytd e
initial amount: NaN
name: Cytidine
boundary condition: false
is: CHEBI:17562
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
has only substance units: false
is: HMDB00089
is: C00475

metaM glyc3p x
initial concentration: 1.0
name: Glycerol 3-phosphate
type: Species
is: C00093
boundary condition: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
is: HMDB00126
is: SBO:0000247
is: CHEBI:57597
constant: false
initial amount: NaN

metaR SMPD4
is: SBO:0000176
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
name: sphingomyelinase
reversible: false
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is described by: ECO:0000000

metaM nh4 x
boundary condition: false
constant: false
is: SBO:0000247
name: Ammonium
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
is: C01342

metaM 5dpmev c
constant: false
initial amount: NaN
type: Species
name: (R)-5-Diphosphomevalonate
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01090
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1

metaR FERO
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
reversible: false
name: ferroxidase
type: Reaction

metaM 2maacoa m
is: CHEBI:57335
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01157
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species
name: 2-methylacetoacetyl-CoA(4-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_88553756_66a8_4071_be6f_0acdc6d235c5
has only substance units: false
name: PKM2
is encoded by: hsa:5315
is: SBO:0000252
type: Species
is: B4DNK4
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaM ptdcacrn m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:18303
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
type: Species
has only substance units: false
initial amount: NaN
name: pendtadenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110049#_2e60a5d6_38a9_413b_99bf_da08446a7483
type: Species
is encoded by: hsa:7991
boundary condition: true
initial concentration: NaN
name: TUSC3
has only substance units: false
constant: false
is: Q13454
is: SBO:0000252
initial amount: NaN

metaR G13MT L
is version of: http://identifiers.org/ec-code/2.4.1.132
type: Reaction
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
is: SBO:0000176
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
is described by: ECO:0000000

metaM HC02213 c
name: prostaglandin-e3
type: Species
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM gtp n
name: GTP(4-)
is: HMDB01273
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:37565
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_03520e31_861d_483b_b873_6abbe58e2c03
is encoded by: hsa:79053
is: SBO:0000252
initial amount: NaN
name: ALG8
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true

metaR r2358
reactant: MODEL1310110049#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110049#
type: Reaction

metaR ACGPID
product: MODEL1310110049#
is: SBO:0000176
fast: false
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is version of: http://identifiers.org/ec-code/3.5.1.89
type: Reaction
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#

metaM rbt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
initial amount: NaN
is: HMDB00508
type: Species
is: SBO:0000247
name: D-ribitol
boundary condition: false
constant: false
is: CHEBI:15963
initial concentration: 1.0

metaR TAURt4 2 r
fast: false
product: MODEL1310110049#
name: taurine transport (sodium symport) (2:1)
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110049#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110049#

metaM gtp m
is: C00044
initial concentration: 1.0
is: CHEBI:37565
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01273
type: Species
name: GTP
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5c46ce9a_2457_456e_baf3_a0801a5af39a
is encoded by: hsa:9551
name: ATP5J2
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: P56134
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_de905757_ed26_4b85_9c50_8614bf1e4457
is: P16930
has only substance units: false
is encoded by: hsa:2184
is: SBO:0000252
type: Species
initial amount: NaN
name: FAH
boundary condition: true
constant: false
initial concentration: NaN

metaR CORE3GTg
fast: false
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaR DM atp c
reversible: false
type: Reaction
name: DM_atp(c)
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#

metaR r2359
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110049#
name: Organic anion transporter 5 Utilized transport
type: Reaction
fast: false
reactant: MODEL1310110049#

metaM lys L x
boundary condition: false
initial amount: NaN
type: Species
name: L-lysinium(1+)
constant: false
is: CHEBI:32551
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: HMDB00182

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR DOLPMT3 Ler
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110049#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.260

metaR B3GNT11g
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110049#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110049#
modifier: MODEL1310110049#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
kinetic law: MODEL1310110049#

metaM ksii core2 deg9 l
has only substance units: false
is: SBO:0000247
type: Species
name: keratan sulfate II (core 2-linked), degradation product 9
boundary condition: false
is: HMDB00143
constant: false
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936

metaM dttp n
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01342
initial amount: NaN
initial concentration: 1.0
type: Species
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
has only substance units: false
is: C00459

metaM gthrd m
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
constant: false
initial concentration: 1.0
name: glutathionate(1-)
is: CHEBI:57925
boundary condition: false
has only substance units: false
is: HMDB00125
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_f0de489f_1489_47ac_8bc1_7521256f4759
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:25769
constant: false
type: Species
name: SLC24A2
initial concentration: NaN
is: Q9UI40

metaR biomass reaction
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000134
fast: false
name: biomass_reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110049#

metaR r0321
kinetic law: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.3.5.2
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
fast: false
reversible: false
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
is: SBO:0000176

metaM HC02213 e
boundary condition: false
type: Species
is: CHEBI:28031
name: prostaglandin-e3
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
has only substance units: false
constant: false
is: SBO:0000247

metaM dolmanp L r
initial concentration: 1.0
is: CHEBI:15809
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
constant: false
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human liver homolog
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_085fdee9_b420_4e76_be9b_b4f4e438d030
name: NME6
is: O75414
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10201
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_487b332d_fd26_48dd_a076_b4425018d22f
has only substance units: false
is encoded by: hsa:3992
initial amount: NaN
constant: false
type: Species
name: FADS1
is: SBO:0000252
boundary condition: true
is: O60427
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_445e0b4c_5c8a_4009_a428_1e885f59f6c6
boundary condition: true
is: SBO:0000252
name: NDUFS2
initial concentration: NaN
is: B7Z792
type: Species
is encoded by: hsa:4720
constant: false
has only substance units: false
initial amount: NaN

metaR r2356
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_f72ab11c_c2de_4bc1_9f10_73ace49cc44a
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: _AI824319_1_r
initial amount: NaN
type: Species
is encoded by: hsa:AI824319

metaM rbt c
name: D-ribitol
initial amount: NaN
type: Species
is: HMDB00508
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:15963
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
constant: false

metaM 4mop m
is: HMDB00695
type: Species
constant: false
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:17865
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

http://identifiers.org/biomodels.db/MODEL1310110049#_274a95d5_13da_410e_b70f_8ea0bea97a68
is: B4DK61
initial amount: NaN
is: SBO:0000252
name: ACOX1
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:51

http://identifiers.org/biomodels.db/MODEL1310110049#_75c0a79c_8c62_49ff_836a_a4c61f2511eb
name: PIGO
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84720
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_64e52f64_eb20_492c_915a_f8e2edfa373f
boundary condition: true
type: Species
has only substance units: false
name: NDUFA5
is: Q16718
initial amount: NaN
is encoded by: hsa:4698
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_7b71ca23_8975_440b_9017_929beae22382
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: PCBD1
initial concentration: NaN
is encoded by: hsa:5092
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_62444298_45e4_4336_9333_0a0b9c14a643
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2629
has only substance units: false
boundary condition: true
name: GBA
is: B7Z6S9
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_510d77b0_5e15_4561_bb8f_a4ddb3aaa4f3
constant: false
is encoded by: hsa:8706
is: B3KTQ4
initial amount: NaN
boundary condition: true
name: B3GALNT1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR r2357
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110049#
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_18fd9788_dc1e_4848_8832_53212f1298b5
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P42765
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:10449
name: ACAA2
type: Species

metaR ACHEe
is described by: ECO:0000269
reactant: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
name: Acetylcholinesterase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.7
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ

metaR r1908
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110049#
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_54f47309_942d_4daf_88e5_c3899c12f6d4
name: GALE
is encoded by: hsa:2582
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: Q38G75
initial concentration: NaN
boundary condition: true
type: Species

metaR r0629
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.6.1.22
reversible: true
type: Reaction
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176

metaR RE3626M
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: false
name: RE3626
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false

metaR O2Stn
fast: false
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110049#
is: SBO:0000185
name: superoxide anion transport via diffusion (nucleus)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110049#

metaM aicar c
initial amount: NaN
is: C04677
initial concentration: 1.0
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
constant: false
type: Species
has only substance units: false
is: HMDB01517

metaM 4mop c
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
constant: false
boundary condition: false
has only substance units: false
is: HMDB00695
is: SBO:0000247
initial amount: NaN
is: CHEBI:17865

http://identifiers.org/biomodels.db/MODEL1310110049#_e8fba581_e3c1_45a5_a91e_7628517729c0
boundary condition: true
is: SBO:0000252
is encoded by: hsa:516
name: ATP5G1
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: P05496

http://identifiers.org/biomodels.db/MODEL1310110049#_107b41ab_d347_481b_9aac_8899ee7abbd6
is encoded by: hsa:6888
name: TALDO1
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: P37837
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaR S6T8g
is: SBO:0000176
reactant: MODEL1310110049#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
fast: false
product: MODEL1310110049#

metaR O2Stm
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: superoxide anion transport via diffusion (mitochondria)
type: Reaction
is: SBO:0000185
reactant: MODEL1310110049#

metaM HC02205 e
name: prostaglandin-b2
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:28099
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_25b7a367_f4e8_4411_a7c6_431d2e45eeb1
initial concentration: NaN
name: MOGS
has only substance units: false
is: F5H6D0
is: SBO:0000252
is encoded by: hsa:7841
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR RE1796R
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
modifier: MODEL1310110049#

metaR PGDI
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: true
is: SBO:0000176
name: Prostaglandin-H2 D-isomerase [Precursor]
kinetic law: MODEL1310110049#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.3.99.2

metaR r0426
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.34

http://identifiers.org/biomodels.db/MODEL1310110049#_2ecd60fd_2baf_4064_8847_33c9c5d5744f
has only substance units: false
initial amount: NaN
type: Species
is: P36269
constant: false
boundary condition: true
is encoded by: hsa:2687
is: SBO:0000252
initial concentration: NaN
name: GGT5

metaR MI1PP
reactant: MODEL1310110049#
is: SBO:0000176
name: myo-inositol 1-phosphatase
is described by: ECO:0000269
modifier: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false
type: Reaction
kinetic law: MODEL1310110049#

metaM cytd n
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00089
is: SBO:0000247
name: cytidine
initial concentration: 1.0
is: CHEBI:17562
constant: false

metaR r0627
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_be314ccc_7b5b_498f_aef8_47a7c0e25c34
is: SBO:0000252
boundary condition: true
constant: false
is: P00558
initial amount: NaN
is encoded by: hsa:5230
type: Species
initial concentration: NaN
has only substance units: false
name: PGK1

metaR GBAl
fast: false
is described by: ECO:0000000
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.45
type: Reaction
is: SBO:0000176
name: Glucosylceramidase
product: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_83d3ca6e_d9ca_49df_acc2_1b80518465c8
boundary condition: true
name: GGH
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q92820
is encoded by: hsa:8836
is: SBO:0000252

metaM dgmp e
type: Species
initial concentration: 1.0
is: CHEBI:57673
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01044
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
name: dGMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110049#_66e30013_42d3_4334_918e_e140b987a8d9
initial amount: NaN
type: Species
is encoded by: hsa:10195
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: ALG3
has only substance units: false

metaR r0425
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
modifier: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.1.4
name: EC:1.1.1.42
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#

metaM aicar e
has only substance units: false
is: C04677
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
constant: false
boundary condition: false
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2
type: Species
initial amount: NaN

metaM HC00822 l
type: Species
has only substance units: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28681
constant: false
name: Chitobiose
is: SBO:0000247

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR PETOHMr hs
type: Reaction
name: phosphatidylethanolamine N-methyltransferase
reversible: false
fast: false
is described by: ECO:0000254
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
is version of: http://identifiers.org/ec-code/2.1.1.17
is: SBO:0000176
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaR GLYt2r
is: SBO:0000185
reactant: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
fast: false
is described by: ECO:0000304
name: glycine reversible transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110049#_b50dfd7c_b700_4ba6_92bc_317d78cc714e
is encoded by: hsa:516
boundary condition: true
type: Species
has part: Q6FIH7
initial concentration: NaN
has only substance units: false
is: SBO:0000297
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
constant: false

metaM tre e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
name: Trehalose
type: Species
is: C01083
initial amount: NaN
is: HMDB00975
is: SBO:0000247
constant: false
is: CHEBI:16551
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_16ebb2ae_2ab5_48bc_a371_b99a0f095cda
type: Species
is: SBO:0000252
name: CMA1
initial amount: NaN
is encoded by: hsa:1215
has only substance units: false
initial concentration: NaN
is: Q4FEB3
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_03c02431_1263_4b1c_a7ae_5c33c69e82b7
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:518
name: ATP5G3
is: P48201
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR r2079
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
modifier: MODEL1310110049#
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_1cd07364_eb0f_4123_984e_a1acd0794a91
type: Species
initial concentration: NaN
name: ALPL
is encoded by: hsa:249
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: B7Z4Y6

metaR r0779
is: SBO:0000176
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110049#

metaM dttp c
is: C00459
is: HMDB01342
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: dTTP
is: CHEBI:37568

metaM uacgam c
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57705
is: HMDB00290
boundary condition: false

metaM gthrd c
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
is: C00051
name: Reduced glutathione
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00125
is: SBO:0000247
boundary condition: false
is: CHEBI:57925
type: Species

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaM lys L n
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
name: L-lysinium(1+)
initial amount: NaN
is: HMDB00182
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaM fum m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:29806
is: HMDB00134
is: C00122
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR UGT1A10r
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reactant: MODEL1310110049#
is described by: ECO:0000134
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is: SBO:0000176
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.17
fast: false

metaR ACOAD1fm
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reversible: false
kinetic law: MODEL1310110049#

metaR DTMPK
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.9
reversible: true
type: Reaction
fast: false
name: dTMP kinase

http://identifiers.org/biomodels.db/MODEL1310110049#_4ece8fc3_3b31_4a40_8fd3_ae3fd22b16a3
is encoded by: hsa:5136
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P54750
constant: false
type: Species
initial amount: NaN
name: PDE1A
initial concentration: NaN

metaR CHAT
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.6
reactant: MODEL1310110049#
name: Choline O-acetyltransferase
fast: false
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_363a239e_7376_45d0_af46_48716f95e3aa
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI761708
type: Species
name: _AI761708_1_m
initial concentration: NaN
is: SBO:0000252

metaM xoldiolone r
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: HMDB02197
is: CHEBI:28477
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_fc55cf83_0312_40cb_85cc_79c7db0552ec
is: Q9UNU6
is encoded by: hsa:1582
name: CYP8B1
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR GPIAT
fast: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is: SBO:0000176
modifier: MODEL1310110049#
name: glucosaminylphosphatidyl inositol acetyltransferase
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
reversible: false

metaM gchola c
name: glycocholate
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00138
type: Species
is: CHEBI:58235

metaM dttp e
is: HMDB01342
initial amount: NaN
constant: false
name: dTTP(4-)
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:37568
initial concentration: 1.0

metaM hexdiac c
name: hexadecanediocacid
initial amount: NaN
is: HMDB00672
constant: false
initial concentration: 1.0
notes: FORMULA: C16H28O4 CHARGE: -2
type: Species
has only substance units: false
is: SBO:0000247
is: C08260
boundary condition: false

metaR B3GNT34g
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
type: Reaction
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaM gthrd e
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: glutathionate(1-)
boundary condition: false
constant: false
is: HMDB00125
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925

metaR PRFGS
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.5.3
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: false
type: Reaction
modifier: MODEL1310110049#
name: phosphoribosylformylglycinamidine synthase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_ff95e00d_eddd_4602_852f_fa4341b46c6e
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PANK1
has only substance units: false
is encoded by: hsa:53354
is: Q8TE04
initial amount: NaN

metaM mi145p c
is: CHEBI:203600
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01498
type: Species
initial concentration: 1.0
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245

metaM ptdcacrn c
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:18303
initial concentration: 1.0
type: Species
is: SBO:0000247
name: pendtadenoyl carnitine
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1

metaR GALASE15ly
reversible: false
type: Reaction
fast: false
name: beta-galactosidase, lysosomal
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM HC00319 c
initial amount: NaN
is: SBO:0000247
is: CHEBI:30794
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
name: Malonate
initial concentration: 1.0

metaM HC02205 c
boundary condition: false
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_afb21702_aa32_4766_8b56_34893e9fe203
is: Q13946
has only substance units: false
name: PDE7A
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:5150
type: Species

metaM 4mop e
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial amount: NaN

metaR r1106
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110049#
reversible: true
fast: false
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185
name: Postulated transport reaction

metaR C8DCe
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of suberyl carnitine into the extra cellular space
type: Reaction

metaR OMHPALTD
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaR SIAASE2ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
name: sialidase, lysosomal
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaM ksii core4 deg3 l
is: HMDB00143
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate II (core 4-linked), degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110049#_b9464a8a_9eb7_4b00_9495_3eab61e40aff
is: Q9UNK4
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PLA2G2D
is encoded by: hsa:26279
type: Species
initial concentration: NaN
initial amount: NaN

metaM pail34p hs c
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
is: CHEBI:57658
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_be522172_9617_4f16_b497_0e212033a173
is encoded by: hsa:51809
initial amount: NaN
constant: false
is: Q86SF2
boundary condition: true
name: GALNT7
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM 3dsphgn c
is: CHEBI:58299
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01480
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
initial concentration: 1.0
initial amount: NaN

metaM L2aadp m
is: SBO:0000247
constant: false
type: Species
name: L-2-aminoadipate(1-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
is: HMDB00510
has only substance units: false

metaR RETt
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: Retinol transport via faciliated diffusion
fast: false
is: SBO:0000185

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_74ad14a3_ffff_496d_91f4_dd024c31a826
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:83530
name: _83530_1_c
type: Species

metaM sucr e
has only substance units: false
is: CHEBI:17992
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: HMDB00258
initial amount: NaN
constant: false
boundary condition: false
name: Sucrose
is: C00089

metaR RE3003M
kinetic law: MODEL1310110049#
fast: false
product: MODEL1310110049#
name: RE3003
type: Reaction
modifier: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000

metaM amp c
notes: FORMULA: C10H12N5O7P CHARGE: -2
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00020
initial amount: NaN
name: AMP
is: CHEBI:3322
is: HMDB00045

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_ad3de42c_b8f5_440b_8e25_ea56d6460a28
name: RDH14
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9HBH5
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:57665

http://identifiers.org/biomodels.db/MODEL1310110049#_c478f79b_bfbd_424a_9d60_43c123b608b5
name: PIGF
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5281
is: Q6IB04
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_4f7fea7a_7630_4c94_8c18_06415297118d
constant: false
is encoded by: hsa:55
type: Species
is: P15309
is: SBO:0000252
name: ACPP
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaM cl c
boundary condition: false
name: Chloride
is: C00115
is: HMDB00492
constant: false
is: CHEBI:3966
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaR SPHK21c
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.91
name: sphingosine kinase 2
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
product: MODEL1310110049#
fast: false

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_a34edb21_71b7_4c60_b1e5_38b54b690247
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:AV717590
name: _AV717590_1_c
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5d3364c2_c4a5_465f_94ae_77096a127edd
has part: Q96I99
type: Species
is: SBO:0000297
has part: P53597
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8802
has only substance units: false
initial amount: NaN
name: SUCLG2:SUCLG1
is encoded by: hsa:8801

metaM xoldiolone c
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: CHEBI:28477
initial amount: NaN
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB02197
type: Species

metaM HC00229 e
is: SBO:0000247
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
name: Isomaltose
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:28189

metaR GLYCt
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: glycerol transport via channel
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d84ced00_529c_42bf_a1e1_b8cc333c6df2
constant: false
is: SBO:0000252
is: Q9H553
initial amount: NaN
has only substance units: false
name: ALG2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:85365
type: Species

metaM gd3 hs g
is: CHEBI:28424
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
initial concentration: 1.0
name: GD3
has only substance units: false
type: Species
constant: false

metaR DHCR72r
reversible: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is: SBO:0000176
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.1.21
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269
name: 7-dehydrocholesterol reductase
type: Reaction
fast: false

metaR NDPK4n
fast: false
modifier: MODEL1310110049#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is: SBO:0000176
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110049#

metaR NACHEX4ly
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal

metaM ksii core2 pre10 g
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 10
initial amount: NaN
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: CHEBI:28067
type: Species

metaM acgal c
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
initial amount: NaN
type: Species
name: N-acetyl-D-galactosamine
is: SBO:0000247
is: CHEBI:28037

metaR r0774
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110049#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
reactant: MODEL1310110049#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:

metaR TPI
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
fast: false
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.1
name: triose-phosphate isomerase
modifier: MODEL1310110049#
is described by: ECO:0000134

metaR Htr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
is described by: ECO:0000000
name: H transporter, endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
fast: false

metaM crn r
constant: false
is: CHEBI:16347
name: (R)-carnitine
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00062
type: Species
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN

metaM HC01401 x
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
constant: false
is: CHEBI:27668
boundary condition: false
has only substance units: false
type: Species

metaR AG13T2g
type: Reaction
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110049#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR ACNAM9PL
is: SBO:0000176
product: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.56
type: Reaction
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
fast: false
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reactant: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_e9740bdd_5dcf_4ca7_aa1c_e86606445910
constant: false
type: Species
boundary condition: true
name: SLC6A3
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q01959
is encoded by: hsa:6531

metaM amp e
constant: false
name: AMP
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:456215
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
is: C00020
has only substance units: false

metaR r0835
modifier: MODEL1310110049#
fast: false
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110049#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

metaR CSPG Ctly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
name: chondroitin sulfate C transport, extracellular to lysosome
product: MODEL1310110049#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_135b4fdf_f5fd_4c73_b600_5517f7e2da7b
is: Q9UIG8
name: SLCO3A1
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:28232
type: Species
has only substance units: false
initial amount: NaN

metaM cl e
is: SBO:0000247
name: Chloride
type: Species
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
has only substance units: false
is: C00115
constant: false
is: HMDB00492
initial concentration: 1.0
boundary condition: false

metaM kynate c
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00715
name: kynurenate
boundary condition: false
is: CHEBI:58454
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
constant: false
initial concentration: 1.0
initial amount: NaN

metaR DTDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
reversible: true
name: dTDP nuclear transport
product: MODEL1310110049#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_8be78a1e_9d76_4739_a94c_36421ccb98a1
boundary condition: true
name: PLCL1
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:5334
initial concentration: NaN
is: Q15111
type: Species
is: SBO:0000252

metaR r0836
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110049#

metaM gchola e
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0
name: glycocholate
initial amount: NaN
constant: false
is: HMDB00138
has only substance units: false
is: SBO:0000247

metaR L LACt4r
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
fast: false
type: Reaction
name: L-lactate reversible transport via sodium symport
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000185

metaR TAURtcx
kinetic law: MODEL1310110049#
type: Reaction
name: taurine transport (sodium symport) (cytosol to peroxisome)
reactant: MODEL1310110049#
is described by: ECO:0000212
product: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
fast: false
is: SBO:0000185

metaM ksi pre2 g
is: C00130
type: Species
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 2
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR AG13T13g
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110049#
product: MODEL1310110049#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110049#
fast: false

metaR FAS160COA
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reversible: false
product: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#

metaM trdox m
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: Oxidized thioredoxin
has only substance units: false
is: CHEBI:18191
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

metaR 5ADTSTSTERONEtr
is: SBO:0000185
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
name: 5 alpha dihydrotesterone intracellular transport
reversible: true
fast: false
kinetic law: MODEL1310110049#

metaR O2Stx
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
reactant: MODEL1310110049#
fast: false
name: superoxide anion transport via diffusion (peroxisome)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaM acac m
is: HMDB00060
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: acetoacetate
type: Species
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN
is: SBO:0000247
is: CHEBI:13705

metaM ksi deg1 l
name: keratan sulfate I, degradation product 1
is: HMDB00174
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: CHEBI:18287

metaR ANTHte
name: Transport of anthranilate
reactant: MODEL1310110049#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_c7ba0362_85fd_4d55_aec0_883a49f25acd
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: ST3GAL3
boundary condition: true
is encoded by: hsa:6487
type: Species
initial concentration: NaN

metaM clpnd c
has only substance units: false
is: SBO:0000247
name: clupanodonic acid
constant: false
boundary condition: false
is: HMDB06528
is: CHEBI:53488
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
type: Species
initial concentration: 1.0
initial amount: NaN

metaR FRDPtcr
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
product: MODEL1310110049#
is described by: ECO:0000134
reversible: true

metaM xoltetrol m
is: HMDB01231
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:17278

metaM ksii core4 deg1 l
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57737
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
name: keratan sulfate II (core 4-linked), degradation product 1
boundary condition: false
is: HMDB00868
constant: false
initial amount: NaN
is: SBO:0000247

metaR r0838
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
name: Free diffusion
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_6ccb479f_cfa7_4c48_b7e5_e5d531bf87ad
constant: false
boundary condition: true
type: Species
is encoded by: hsa:8528
name: DDO
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q99489
has only substance units: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_2e5872e6_6687_4f4f_b539_80c6eb1077d9
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:55650
name: PIGV
is: Q9NUD9
has only substance units: false
constant: false
initial amount: NaN

metaR r0422
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
fast: false
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_fa6abc76_5a2c_43a0_b746_c1bb9fd73fc8
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: PRDX2
is encoded by: hsa:7001

http://identifiers.org/biomodels.db/MODEL1310110049#_7652d6f8_95d2_4a5e_a660_a409abeb5aaf
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:AI769281
name: _AI769281_1_e
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaM asn L m
name: L-asparagine
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
is: HMDB00168
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17196

metaR H2CO3D
name: carboxylic acid dissociation
reactant: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.1
fast: false
type: Reaction
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000000

metaR r0839
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.1.70
type: Reaction
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_47fcae48_8b7f_47e2_b60e_9965885852e5
name: BCKDHB
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:594
is: P21953
has only substance units: false
constant: false

metaR r1177
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110049#
name: EC:3.1.1.13
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
fast: false
is: SBO:0000176

metaR S23T2g
reversible: false
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD

metaM dgmp c
has only substance units: false
initial amount: NaN
is: C00362
boundary condition: false
is: SBO:0000247
is: HMDB01044
type: Species
name: dGMP
is: CHEBI:57673
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaR r0423
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
modifier: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
kinetic law: MODEL1310110049#
fast: false

metaM clpnd e
type: Species
is: SBO:0000247
constant: false
is: CHEBI:53488
initial amount: NaN
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
has only substance units: false
is: HMDB06528
initial concentration: 1.0
name: clupanodonic acid
boundary condition: false

metaM ksii core4 pre3 g
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00175
type: Species
has only substance units: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 3
is: C00130
boundary condition: false
is: CHEBI:58053

metaR EX c4crn
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_332ef5c1_1bde_461d_aa9b_87cde0e7ccd2
initial concentration: NaN
is: O95299
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:4705
type: Species
is: SBO:0000252
has only substance units: false
name: NDUFA10

http://identifiers.org/biomodels.db/MODEL1310110049#_7dbcdce6_1b4b_4dab_a9df_059775c43715
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:23305
is: SBO:0000252
constant: false
initial concentration: NaN
is: B2RB13
boundary condition: true
name: ACSL6

metaR ICDHyrm
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
kinetic law: MODEL1310110049#
name: Isocitrate dehydrogenase (NADP+)
is described by: ECO:0000269
fast: false
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
reversible: true

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

metaR PROSTGE2t2
is: SBO:0000185
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#
name: prostaglandin uniport
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR GULN3D
reactant: MODEL1310110049#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
name: L-gulonate 3-dehydrogenase

metaR r0424
modifier: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110049#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.17.1.4
reversible: true
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_02d18a1a_9441_4b9b_9fde_82e7221758d8
is: Q9NRX3
has only substance units: false
name: NDUFA4L2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:56901
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaM gdpddman c
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
type: Species
is: CHEBI:57964
is: HMDB01346
has only substance units: false
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial concentration: 1.0

metaM 34dhoxmand c
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
name: 3,4-Dihydroxymandelate
initial concentration: 1.0
is: HMDB01866
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

metaR BTNDm
name: biotinidase (biotin), mitochondrial
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
kinetic law: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.1.12
product: MODEL1310110049#

metaM HC01401 m
initial amount: NaN
type: Species
is: CHEBI:27668
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: SBO:0000247
constant: false

metaR r2365
reversible: true
product: MODEL1310110049#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_f54527cc_45b9_41bc_a04b_0f3d795364b2
constant: false
is: B1AM93
name: NDUFA8
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:4702
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ad661dfd_f6d1_404b_b7b1_d3a48a67873f
is: P14410
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: SI
is encoded by: hsa:6476
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_c57e529f_855b_4ec0_ad0a_eab90081dd03
name: PPAP2C
constant: false
initial concentration: NaN
initial amount: NaN
is: E9PAY8
has only substance units: false
is encoded by: hsa:8612
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_b8a1f574_c505_48f1_be8b_da09f5dd486c
type: Species
initial amount: NaN
is: P43007
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLC1A4
initial concentration: NaN
is encoded by: hsa:6509
constant: false

metaR r0308
is: SBO:0000176
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reversible: false
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_684f4d3b_82cb_4c90_95a6_294b3b29f55b
has only substance units: false
constant: false
initial concentration: NaN
has part: Q86U05
initial amount: NaN
name: SLC7A8:SLC3A2
is: SBO:0000297
is encoded by: hsa:23428
boundary condition: true
type: Species

metaR r0531
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_08fc7e0b_8042_4751_a2d8_a0a7e659837a
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ENPP3
is encoded by: hsa:5169
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: Q308M7

metaR r2364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110049#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#

metaM fpram c
constant: false
initial amount: NaN
is: C04640
is: SBO:0000247
is: CHEBI:58478
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB06211

metaM ksi deg8 l
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 8
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
has only substance units: false
is: HMDB00143
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_52e1e0ea_6e38_4bd7_ad85_00edeb543e60
type: Species
is: A6NFM2
initial amount: NaN
boundary condition: true
constant: false
name: PYCR1
is encoded by: hsa:5831
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_f268613a_b261_4a15_ba24_0ec02eee41f7
type: Species
name: ACP2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:53
is: E9PCI1
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaR Htg
fast: false
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
name: proton diffusion (Golgi)
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_efd22c31_d216_4ed8_ba20_9e15877740b6
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: O75610
is encoded by: hsa:10637
name: LEFTY1
initial amount: NaN
initial concentration: NaN

metaR ORNt3m
product: MODEL1310110049#
name: ornithine mitochondrial transport via proton antiport
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d973bc8c_5534_4527_a18a_d732936c0c8b
has only substance units: false
name: ACAD10
is: G3XAJ0
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80724
initial amount: NaN
constant: false

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR r2367
reversible: true
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110049#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110049#_fdb0e3e6_0c1d_490f_bc1e_e02abf8fc139
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: MSMO1
is encoded by: hsa:6307
constant: false
has only substance units: false
initial amount: NaN
is: A8MYF6

metaR PHCDm
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.5.1.12
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
type: Reaction
modifier: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#

metaR DOLPMT2 Ler
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
product: MODEL1310110049#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_633ad3b4_0bc3_48c5_8abe_e7681d3b393f
name: CA12
constant: false
boundary condition: true
is encoded by: hsa:771
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM L2aadp c
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: L-2-aminoadipate(1-)
is: CHEBI:58672
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaM dolp U r
is: SBO:0000247
is: CHEBI:57683
boundary condition: false
initial concentration: 1.0
name: dolichyl phosphate(2-)
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_585cfe0e_2a8f_4a2a_b1c9_9630089593dd
type: Species
boundary condition: true
constant: false
name: COX5A
is: P20674
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9377
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_14951d72_3063_49d2_9193_b195f877b2c4
type: Species
initial amount: NaN
is: Q7Z7B1
constant: false
has only substance units: false
is encoded by: hsa:284098
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PIGW

http://identifiers.org/biomodels.db/MODEL1310110049#_6e90ea0e_ab20_486a_a20a_69cac4143d59
is encoded by: hsa:1120
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: CHKB
has only substance units: false
initial concentration: NaN
is: A0PJM6

http://identifiers.org/biomodels.db/MODEL1310110049#_618e709a_c748_4088_b576_bb6c64f335c7
initial amount: NaN
boundary condition: true
name: PLA2G2F
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:64600
is: Q9BZM2
is: SBO:0000252
constant: false

metaR GLYtm
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
fast: false
type: Reaction
is: SBO:0000185
reversible: true
name: glycine passive transport to mitochondria
reactant: MODEL1310110049#

metaR r1172
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000000
name: EC:3.1.1.13
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false

metaR r2366
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
product: MODEL1310110049#
fast: false

metaR SERALANaEx
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_8df67402_1e79_491a_93f3_a34b578feb3f
is: SBO:0000252
name: NDUFB7
constant: false
is: P17568
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4713

http://identifiers.org/biomodels.db/MODEL1310110049#_eea57930_1198_451f_9065_167cf1c69997
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: TPI1P2
type: Species
is: SBO:0000252
is encoded by: hsa:286016
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_56758cc2_4b01_48bb_95d7_40e42a37d7c9
is encoded by: hsa:3422
is: SBO:0000252
name: IDI1
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: Q13907
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_71d11794_80c1_4603_9518_8815ae7e720d
has only substance units: false
initial amount: NaN
is: E9PB82
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: HSD17B4
boundary condition: true
is encoded by: hsa:3295

metaR VALTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: valine transaminase, mitochondiral
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false

metaR DGNSKm
type: Reaction
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
kinetic law: MODEL1310110049#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
reactant: MODEL1310110049#
name: deoxyguanosine kinase
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.113

http://identifiers.org/biomodels.db/MODEL1310110049#_8ab65da8_cefd_4650_8566_4350f9c1cd32
has only substance units: false
is encoded by: hsa:2805
initial concentration: NaN
name: GOT1
is: P17174
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110049#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110049#

metaR G14T8g
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110049#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_e1760d86_5a6d_4ce5_8cec_eedc33eacc02
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:2597
initial concentration: NaN
boundary condition: true
is: E7EUT4
is: SBO:0000252
name: GAPDH

metaM chtn e
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
type: Species
initial amount: NaN
name: chitin
is: HMDB03362
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17029
has only substance units: false

metaR H2Oter
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_e93b2046_d207_4f5e_bac1_acc3dcafb3c8
constant: false
boundary condition: true
type: Species
is encoded by: hsa:4722
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O75489
name: NDUFS3

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_d0eed0cb_2a40_460c_8304_614b98c57ba6
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:8790
constant: false
name: FPGT
has only substance units: false
boundary condition: true
is: O14772

metaR MANt1r
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
fast: false
name: mannose transport (uniport)
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_d6d62f9f_b5bb_4fc6_b283_36f64082a94d
is: O95169
is encoded by: hsa:4714
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
name: NDUFB8
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_17679e8d_0ea4_4f69_93d8_0d3e0ce8b947
is: C9JC79
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6342
boundary condition: true
constant: false
type: Species
name: SCP2

http://identifiers.org/biomodels.db/MODEL1310110049#_91b9b97a_5be8_456b_9db9_289895a61a2c
boundary condition: true
name: DGUOK
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:1716
is: E5KSL6
initial concentration: NaN

metaM 6pgl r
is: HMDB01127
is: CHEBI:57955
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
initial amount: NaN
constant: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_e376d481_077f_4f8d_8823_32ffa00f9125
type: Species
name: DEGS1
initial amount: NaN
initial concentration: NaN
is: O15121
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8560

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR PROSTGF2t
is described by: ECO:0000269
is: SBO:0000185
name: prostaglandin uniport
type: Reaction
reversible: true
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#

metaR r0830
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
product: MODEL1310110049#

metaR FUT910g
is version of: http://identifiers.org/ec-code/2.4.1.152
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
name: Alpha-(1,3)-fucosyltransferase
product: MODEL1310110049#

metaM crn m
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
is: HMDB00062
has only substance units: false
constant: false
is: SBO:0000247
name: L-Carnitine
type: Species
is: CHEBI:16347
boundary condition: false
initial amount: NaN

metaR KSII CORE4t
reversible: false
product: MODEL1310110049#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110049#
name: keratan sulfate II (core4) transport, golgi to extracellular
reactant: MODEL1310110049#

metaR r2363
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110049#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM asn L e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false
constant: false
is: HMDB00168
is: CHEBI:17196
type: Species
name: L-asparagine

metaR GALASE3ly
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110049#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is: SBO:0000176
reversible: false

metaR RE0344C
name: RE0344
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reactant: MODEL1310110049#
reversible: true
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
kinetic law: MODEL1310110049#

metaM cytd c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00089
is: CHEBI:17562
constant: false
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
boundary condition: false
name: Cytidine

metaM ca2 e
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: calcium(2+)
is: HMDB00464
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
constant: false
type: Species
is: CHEBI:29108
initial amount: NaN

metaM acgal g
has only substance units: false
name: N-acetyl-D-galactosamine
type: Species
is: CHEBI:28037
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00212
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132

metaM acac x
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:13705
is: HMDB00060
name: acetoacetate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR TDCHOLAtx
is described by: ECO:0000000
name: bile acid intracellular transport
kinetic law: MODEL1310110049#
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaM itp n
initial amount: NaN
type: Species
constant: false
is: HMDB00189
is: SBO:0000247
name: ITP(3-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
is: CHEBI:57614

metaR ACACtx
reversible: true
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: acetoacetate intracellular transport unknown mechanism
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction

metaR r2362
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110049#

metaM dhcrm hs c
is: CHEBI:31488
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: dihydroceramide
type: Species
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126

http://identifiers.org/biomodels.db/MODEL1310110049#_d076dc8f_0c5e_4c66_8de7_4cbc251c5e0f
is encoded by: hsa:4713
constant: false
is: SBO:0000252
name: NDUFB7
initial concentration: NaN
is: P17568
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaR CGLYt3 2
reversible: false
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
name: Cys-Gly transport in via proton symport
fast: false

metaR 3MOPte
reversible: true
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxopentanoate
is: SBO:0000185
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR FRDPtr
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ

metaM asn L c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00168
name: L-asparagine
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: SBO:0000247
constant: false
is: CHEBI:17196
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_3586d3b2_9c8f_4544_b06b_9074d1dd8e8b
initial amount: NaN
name: _BE966236_1_m
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:BE966236
initial concentration: NaN
type: Species

metaR PI345P5P
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.86
reactant: MODEL1310110049#
fast: false
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
reversible: false
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
product: MODEL1310110049#
is: SBO:0000176

metaR r0527
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
fast: false
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#

metaM pail45p hs c
initial amount: NaN
is: CHEBI:28910
constant: false
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
has only substance units: false

metaR ACHtn
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false
name: Acetylcholin transport, nuclear trhough pores
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reactant: MODEL1310110049#

metaR LEUTAm
name: leucine transaminase, mitochondrial
is: SBO:0000176
fast: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000269

metaR DOLPMT1 Ler
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.258
reversible: false
type: Reaction
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c31a5a89_ba67_4658_9f90_62ee7daf923d
name: ALDH1A3
boundary condition: true
is: P47895
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:220
has only substance units: false

metaM acgam r
name: N-acetyl-D-glucosamine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
initial amount: NaN
is: CHEBI:17411
boundary condition: false
is: HMDB00215

http://identifiers.org/biomodels.db/MODEL1310110049#_fdd2dc2c_8171_407c_8a45_697361e5bb94
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is: Q96PL7
is encoded by: hsa:9154
has only substance units: false
initial concentration: NaN
constant: false
name: SLC28A1

metaR GRTTx
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000134
fast: false
name: geranyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110049#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_01f89d20_22f0_48c6_bf3d_97a24164a3ed
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57194
is: O60312
is: SBO:0000252
has only substance units: false
constant: false
name: ATP10A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_9f96d258_68af_48c4_8db8_f81dada4648d
initial amount: NaN
type: Species
name: SLC5A2
is encoded by: hsa:6524
constant: false
boundary condition: true
is: P31639
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR S6TASE5ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: true
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110049#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000

metaR PDHm
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.1
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
name: pyruvate dehydrogenase
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4

http://identifiers.org/biomodels.db/MODEL1310110049#_21811dd0_4ecf_43d9_bfc9_9b826337cd1a
name: GALT
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: E7ET32
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2592

http://identifiers.org/biomodels.db/MODEL1310110049#_3aa8d3df_6660_4146_8240_c8b21aa38dd2
name: FUT9
is encoded by: hsa:10690
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: Q9Y231
is: SBO:0000252
boundary condition: true

metaR B3GNT33g
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000269
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

metaR r0610
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110049#
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110049#

metaR HYXNt
fast: false
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
product: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110049#
name: Hypoxanthine transport

metaR NACHEXA14ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110049#_eeeffdb5_334d_4b26_8488_3948e12b33ba
initial amount: NaN
name: ALDH3B2
initial concentration: NaN
boundary condition: true
type: Species
is: P48448
is encoded by: hsa:222
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_3d7aa4df_154e_4dd1_8f8f_7dba6a09a9f3
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA664770
boundary condition: true
name: _AA664770_1_m

metaR CH25H
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.14.99.38
name: cholesterol 25-hydroxylase
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
reversible: false
is described by: ECO:0000269

metaM acac c
boundary condition: false
is: CHEBI:13705
is: HMDB00060
initial concentration: 1.0
has only substance units: false
name: acetoacetate
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_b29891e0_60eb_4c76_8bc9_2a834065be64
has only substance units: false
is: Q674R7
is: SBO:0000252
initial amount: NaN
name: ATG9B
is encoded by: hsa:285973
boundary condition: true
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_89154f1e_db2b_4c57_ae39_e89a1a489f12
boundary condition: true
constant: false
name: RDH14
is: Q9HBH5
type: Species
has only substance units: false
is encoded by: hsa:57665
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR GDPFUCtg
is described by: ECO:0000269
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110049#
name: GDPFuc Golgi transport via CMP antiport
reversible: true
product: MODEL1310110049#
is: SBO:0000185

metaR NACDe
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR RE2649C
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110049#
is described by: ECO:0000000
name: RE2649
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
reversible: true
fast: false

metaM c8dc c
initial amount: NaN
is: SBO:0000247
name: suberyl carnitine
is: HMDB00705
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C15H26NO6 CHARGE: -1
type: Species

metaM itp c
constant: false
name: ITP(3-)
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57614
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c666f4cd_28a0_4d4d_b4ca_d3344ae6a745
initial amount: NaN
is encoded by: hsa:5831
constant: false
boundary condition: true
type: Species
is: A6NFM2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PYCR1

metaR DSAT
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: dihydrosphingosine N-acyltransferase
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

metaR F1PGT
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110049#
reversible: true
name: fucose-1-phosphate guanylyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.30
kinetic law: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#
product: MODEL1310110049#

metaR r2368
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM ficytC m
is: CHEBI:15991
initial amount: NaN
is: SBO:0000247
name: Ferricytochrome c
constant: false
initial concentration: 1.0
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
boundary condition: false
has only substance units: false
type: Species

metaM for c
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00142
is: C00058
name: Formate

metaM CE2417 m
is: CHEBI:28387
is: HMDB11123
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaR r0523
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
is: SBO:0000176
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_84c163b8_61ed_47b3_8b40_5c28e563b221
initial concentration: NaN
is: SBO:0000252
name: PDE7A
is encoded by: hsa:5150
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaR ASNGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is described by: ECO:0000269
fast: false
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR PYDXDH
name: pyridoxal dehydrogenase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.3.1
type: Reaction
fast: false

metaR XYLUR
modifier: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
name: xylulose reductase
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.10

http://identifiers.org/biomodels.db/MODEL1310110049#_c01119c0_7ed8_4961_a988_9daa5cb6cc0c
is encoded by: hsa:130367
is: Q8IWX5
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SGPP2
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_03281caa_3514_4a9e_97e9_35ed6bef520a
has only substance units: false
is: P56381
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:514
boundary condition: true
name: ATP5E
constant: false

metaM for e
initial amount: NaN
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
has only substance units: false
constant: false
name: formate
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00142

metaR r0611
type: Reaction
is: SBO:0000176
reactant: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
reversible: true
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
is described by: ECO:0000000
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.3.1

metaM HC01007 c
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
name: L-Octanoylcarnitine
has only substance units: false
boundary condition: false
is: CHEBI:18102
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaR r2369
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110049#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_15930032_4f44_4e0d_aea8_0d10c6a2f5a5
is encoded by: hsa:65010
constant: false
type: Species
name: SLC26A6
initial amount: NaN
is: SBO:0000252
is: Q9NQU1
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM dolp U c
is: SBO:0000247
is: CHEBI:57683
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_a75e83e9_c4df_4127_80e5_731b9f8214d3
has only substance units: false
type: Species
name: ACOX3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8310
is: O15254
constant: false
boundary condition: true

metaR DHPM1
reversible: false
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
name: dihydropyrimidinase (5,6-dihydrouracil)
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.2.2

metaR r0522
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
fast: false
reversible: false
reactant: MODEL1310110049#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000

metaM crn c
name: L-Carnitine
is: C00318
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
boundary condition: false
constant: false
type: Species
is: CHEBI:16347

metaR GAPD
name: glyceraldehyde-3-phosphate dehydrogenase
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.12
is: SBO:0000176
fast: false
product: MODEL1310110049#
is described by: ECO:0000134
modifier: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
type: Reaction
kinetic law: MODEL1310110049#

metaR B3GNT12g
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
is described by: ECO:0000269
reversible: false
fast: false

metaM itp e
initial concentration: 1.0
is: HMDB00189
type: Species
is: CHEBI:57614
initial amount: NaN
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
has only substance units: false
is: SBO:0000247
name: ITP(3-)

metaM ksi pre14 g
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
has only substance units: false
is: SBO:0000247
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 14
boundary condition: false

metaM q10h2 m
type: Species
is: HMDB13111
name: Ubiquinol-10
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
constant: false
is: http://identifiers.org/pubchem.compound/6504740

metaM c8dc e
has only substance units: false
is: SBO:0000247
is: HMDB00705
constant: false
name: suberyl carnitine
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C15H26NO6 CHARGE: -1

metaR ABTArm
modifier: MODEL1310110049#
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r0614
fast: false
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
reactant: MODEL1310110049#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110049#

metaR FUCASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.51
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is: SBO:0000176
type: Reaction
name: alpha-fucosidase, lysosomal
modifier: MODEL1310110049#
fast: false
reversible: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#

metaR GALASE14ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110049#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110049#
name: beta-galactosidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR FUMTSULtm
fast: false
name: Fumarate:thiosulfate antiport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
reversible: true
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
reactant: MODEL1310110049#

metaR r0311
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
modifier: MODEL1310110049#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3

metaM Rtotal l
is: CHEBI:52639
initial amount: NaN
constant: false
has only substance units: false
name: R total
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: CO2FULLR CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110049#_1dd45b2e_4fc9_484c_83d5_dbeec6b1ff1a
name: _AI348006_1_c
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI348006
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_85beed21_6943_4804_9e8f_a72a0eb1df76
name: PIGF:PIGO
initial concentration: NaN
has part: Q6IB04
constant: false
is encoded by: hsa:5281
is: SBO:0000297
type: Species
is encoded by: hsa:84720
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_99043feb_2f4d_4cd0_a06b_266c8fa1cd34
boundary condition: true
name: _AU149534_1_c
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:AU149534
constant: false
is: SBO:0000252
initial amount: NaN

metaR RE2799C
reversible: true
name: RE2799
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
product: MODEL1310110049#
fast: false
is described by: ECO:0000000

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM prostgi2 e
name: prostaglandin I2(1-)
type: Species
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
is: CHEBI:57403
is: HMDB01335
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR ASPPROASCT1
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110049#
name: aspartate intake by system ASCT-1 transporter
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
reactant: MODEL1310110049#
product: MODEL1310110049#

metaM crn e
is: C00318
initial amount: NaN
is: SBO:0000247
name: L-Carnitine
initial concentration: 1.0
is: HMDB00062
constant: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
type: Species
is: CHEBI:16347

metaR r0310
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110049#
is: SBO:0000176
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
reversible: false

metaR Htx
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
name: H transporter, peroxisome
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110049#
fast: false

metaR r2061
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_90eafab3_1e53_49fa_8219_6dbeac3d6d6b
initial amount: NaN
initial concentration: NaN
name: CPT1C
is encoded by: hsa:126129
is: Q8TCG5
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaR r0616
modifier: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: true
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaR TDCHOLAte
kinetic law: MODEL1310110049#
name: bile acid intracellular transport
product: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction

metaR RE0935E
fast: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
product: MODEL1310110049#
type: Reaction
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_d7381274_d510_4618_b286_bc897c673e7f
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:250
name: ALPP
is: P05187
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_8ad21c44_a623_40f4_9128_d33fc51bd857
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:84532
initial concentration: NaN
is: Q9NUB1
name: ACSS1
initial amount: NaN

metaR PI4PLC
kinetic law: MODEL1310110049#
reversible: false
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol 4-phosphate phospholipase C
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176

metaM ksi deg27 l
type: Species
name: keratan sulfate I, degradation product 27
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: HMDB00143
is: CHEBI:12936

metaR r0615
is version of: http://identifiers.org/ec-code/2.3.1.168
reactant: MODEL1310110049#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: true

metaM dhcholestancoa x
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: CHEBI:15494
is: HMDB02159
is: SBO:0000247

metaR r0990
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_acecc323_6574_454d_b6df_6a247a29160a
is: B4DP47
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: BCKDHA
has only substance units: false
is encoded by: hsa:593
initial concentration: NaN
is: SBO:0000252

metaR r1919
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110049#
reversible: false
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_47a4e54a_6d6c_4a02_b026_48bf14a7dd67
boundary condition: true
constant: false
is encoded by: hsa:56922
name: MCCC1:MCCC2
is: SBO:0000297
has part: Q9HCC0
is encoded by: hsa:64087
has part: Q96RQ3
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaR r0202
is described by: ECO:0000000
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
fast: false
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000176
product: MODEL1310110049#
reactant: MODEL1310110049#

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR CYTDtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110049#
name: cytidine transport in nucleus
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
product: MODEL1310110049#

metaM pail45p hs m
type: Species
constant: false
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
initial amount: NaN
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_615309b5_4c6f_4e0a_83ed_5e038a4af999
name: CAD
initial amount: NaN
type: Species
is: P27708
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:790

metaR r0618
product: MODEL1310110049#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM hdca r
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
is: C00249
is: CHEBI:7896
is: HMDB00220
has only substance units: false
initial amount: NaN
name: Hexadecanoate (n-C16:0)
boundary condition: false

metaR PPA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
fast: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
name: inorganic diphosphatase
reversible: false
type: Reaction
is: SBO:0000176

metaM ksi pre3 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 3
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: C00130
is: CHEBI:58053
constant: false
initial concentration: 1.0
is: HMDB00175
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247

MODEL1310110049#
species: metaM succ m
species: metaM g3m8masn r
species: metaM nh4 e
species: metaM dgchol c
species: metaM nadh c
species: metaM ksi pre27 g
species: metaM hdd2coa m
species: metaM gal14acglcgalgluside hs g
species: metaM uri c
species: metaM coa c
species: metaM 5fthf m
species: metaM dmnoncrn m
species: metaM HC01007 m
species: metaM crm hs g
species: metaM adpcoa x
species: metaM fprica c
species: metaM ha pre1 e
species: metaM CE5236 c
species: metaM cl c
species: metaM fad e
species: metaM biocyt n
species: metaM 2kmb c
species: metaM Lcystin e
species: metaM ksii core4 l
species: metaM ksii core4 pre8 g
species: metaM gthrd c
species: metaM 2oxoadp c
species: metaM cdp e
species: metaM hxan c
species: metaM h2o l
species: metaM csn c
species: metaM itaccoa m
species: metaM leuktrA4 e
species: metaM CE2431 m
constant: false
species: metaM duri e
species: metaM lnlnca l
species: metaM sebcoa x
species: metaM akg c
species: metaM leu L e
species: metaM gbside hs l
species: metaM 4abut e
species: metaM ac e
species: metaM leuktrC4 c
species: metaM drib c
stoichiometry: 3.0
species: metaM ins c
species: metaM retinal c
species: metaM hom L c
species: metaM s2l2fn2m2masn e
species: metaM aps c
species: metaM thyox L e
species: metaM pmtcoa c
species: metaM hco3 c
species: metaM ksii core4 deg3 l
species: metaM dgdp m
species: metaM m4masn g
species: metaM 4fumacac c
species: metaM clpn hs c
species: metaM 4abutn e
species: metaM ksii core2 pre7 g
species: metaM dadp n
species: metaM 10fthf5glu e
species: metaM fad c
species: metaM imp c
species: metaM cgly e
species: metaM 3dhguln c
species: metaM hexdiac r
species: metaM ksii core2 deg6 l
species: metaM acgam r
species: metaM pydam c
species: metaM m3mpdol L c
species: metaM gal1p c
species: metaM odecoa c
species: metaM oagt3 hs c
species: metaM thr L c
species: metaM ksii core4 e
species: metaM c8dc c
species: metaM HC00319 m
species: metaM no e

http://identifiers.org/biomodels.db/MODEL1310110049#_57e2f4e2_d046_4b5f_ad5a_8e229180c9c4
initial concentration: NaN
is encoded by: hsa:4357
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: MPST
is: P25325

metaR PRPPS
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.6.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
type: Reaction
name: phosphoribosylpyrophosphate synthetase

metaM pail45p hs n
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
is: CHEBI:28910
constant: false
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate

metaR r0617
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110049#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176

metaM Sfglutth c
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: S-formylglutathionate(1-)
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: HMDB01550
type: Species
is: SBO:0000247
is: CHEBI:57688
boundary condition: false

metaM ksii core2 pre6 g
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28067
is: SBO:0000247
notes: FORMULA: C61H98N5O46SX CHARGE: -2
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false
constant: false

metaR LDH L
is described by: ECO:0000000
name: L-lactate dehydrogenase
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
product: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
reactant: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_37af64cd_2ddd_4ae8_9634_b8369214ec44
initial amount: NaN
has only substance units: false
name: ESPN
boundary condition: true
constant: false
is encoded by: hsa:83715
initial concentration: NaN
type: Species
is: SBO:0000252
is: B1AK53

http://identifiers.org/biomodels.db/MODEL1310110049#_d8f8627f_5e4f_460b_a2ec_a9e6154ae190
type: Species
constant: false
name: EHHADH
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1962
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9NY65

metaM acgam l
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
is: HMDB00215
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-glucosamine
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_4b8ecf0e_0209_4237_a5db_c67a272a7d5e
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AV717590_1_m
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AV717590

metaR r2065
kinetic law: MODEL1310110049#
type: Reaction
reversible: false
modifier: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_64c6ee8d_ae60_4ebc_a1e9_214e2541325a
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: UPB1
has only substance units: false
constant: false
is: B3KNC1
type: Species
is encoded by: hsa:51733

metaR GASNASEly
fast: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110049#
modifier: MODEL1310110049#
name: glycosylasparaginase, lysosomal
product: MODEL1310110049#
type: Reaction

metaR THYOXt2
product: MODEL1310110049#
fast: false
name: T4 transport via facilitated diffusion
modifier: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269

metaR ARABR
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
type: Reaction
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
name: arabinose reductase
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2

metaR ALATHRNaEx
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000185
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
reversible: false
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false

metaM acglcgalgluside hs g
type: Species
constant: false
is: SBO:0000247
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
boundary condition: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
is: CHEBI:17103
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_b31081e4_0e87_4186_962d_4a600ae17d71
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM nh4 c
constant: false
name: Ammonium
is: C01342
initial amount: NaN
is: HMDB00051
is: CHEBI:28938
type: Species
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR RTOTAL2t
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport
fast: false
is described by: ECO:0000000

metaM acac e
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
initial concentration: 1.0
is: CHEBI:13705
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB00060
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_1998986a_f2bc_4008_949e_391c9924576a
type: Species
name: ALDH3A1
is: P30838
is: SBO:0000252
is encoded by: hsa:218
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

metaR S6T7g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#

metaM HC02121 c
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: S-(hydroxymethyl)glutathione(1-)
constant: false
is: CHEBI:58758
has only substance units: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_ec72ee41_d1bd_4a2d_8d6f_f79aa160d889
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:2650
is: SBO:0000252
name: GCNT1
is: Q02742
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_fabf0a83_3906_49e4_99c8_21731cbb801c
is encoded by: hsa:6523
initial amount: NaN
name: SLC5A1
is: P13866
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM abt c
boundary condition: false
constant: false
is: HMDB01851
is: CHEBI:18403
type: Species
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
initial concentration: 1.0
name: L-arabinitol
initial amount: NaN

metaR r2067
type: Reaction
kinetic law: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110049#

metaR TTDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
fast: false
type: Reaction
name: tetradecanoate (transport)
is described by: ECO:0000269
kinetic law: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
product: MODEL1310110049#

metaR RE2677G
is: SBO:0000176
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
type: Reaction
reactant: MODEL1310110049#
fast: false
name: RE2677
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d064f050_39c9_40c6_97b3_ae299a4312a0
is encoded by: hsa:9651
boundary condition: true
is: O75038
initial concentration: NaN
is: SBO:0000252
constant: false
name: PLCH2
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_59bff453_1a80_4013_bc94_5b1a03e9e336
type: Species
initial amount: NaN
initial concentration: NaN
name: GALK2
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:2585
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_338a13b4_b7d4_406f_847c_91c0d0c883af
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLC26A6
is encoded by: hsa:65010
is: Q9Y3Y1
type: Species

metaR DURIK1
fast: false
is: SBO:0000176
name: deoxyuridine kinase (ATP:Deoxyuridine)
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110049#
is described by: ECO:0000254

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM HC01007 m
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: L-Octanoylcarnitine
is: SBO:0000247
boundary condition: false
is: CHEBI:18102
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
has only substance units: false

metaM abt e
has only substance units: false
name: L-arabinitol
constant: false
boundary condition: false
is: HMDB01851
is: CHEBI:18403
is: SBO:0000247
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
initial concentration: 1.0

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_269ce929_426d_4f5b_97fc_cb89f265bb08
constant: false
type: Species
is: SBO:0000252
name: _J03866_1_m
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:J03866
boundary condition: true

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r1606
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110049#
reversible: true
is described by: ECO:0000000

metaR r2195
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110049#
reversible: true
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR RE3000M
type: Reaction
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
name: RE3000
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_e3d2d96f_8e77_4ce8_bc3b_da178f960973
name: ALG3
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:10195
is: Q92685
initial amount: NaN
initial concentration: NaN
constant: false

metaR UDPGALtg
reactant: MODEL1310110049#
reversible: true
name: UDP-Gal Golgi transport via CMP antiport
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#

metaR r0384
is described by: ECO:0000000
is: SBO:0000176
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
type: Reaction
kinetic law: MODEL1310110049#
fast: false
reversible: false
reactant: MODEL1310110049#
product: MODEL1310110049#

metaR r2088
type: Reaction
reactant: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
modifier: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#

metaR RE3346M
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is: SBO:0000176
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: RE3346
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
reversible: true

metaR RE3273C
name: RE3273
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110049#
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true

metaR r1605
fast: false
product: MODEL1310110049#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
has only substance units: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
is: CHEBI:26174
initial amount: NaN
boundary condition: false

metaM tyr L e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: L-tyrosine
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
is: CHEBI:17895
is: SBO:0000247

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
type: Reaction
name: sialidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_fc8d3326_e267_4ee4_902b_3f61579d5892
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: CPT1B
is: E9PCP2
initial amount: NaN
is encoded by: hsa:1375

metaM leugly e
initial amount: NaN
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/97364
initial concentration: 1.0
name: Leucylglycine

metaR VITD3t2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reversible: false
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
name: Vitamin D3 uptake
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false

metaR r2194
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
modifier: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000

metaM h r
name: proton
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
is: C00080
initial concentration: 1.0

metaR r2087
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110049#

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_b38bad71_621c_4e9b_8ed6_b9ad2bd6fb33
is encoded by: hsa:R39999
constant: false
initial concentration: NaN
initial amount: NaN
name: _R39999_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaM hmgcoa x
is: HMDB01375
boundary condition: false
name: Hydroxymethylglutaryl-CoA
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_e4866e16_2a26_48ba_a6b4_6fe7f348cc89
is: SBO:0000252
is: Q63HM1
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:125061
name: AFMID
constant: false
boundary condition: true
type: Species

metaR GCNTg
is version of: http://identifiers.org/ec-code/2.4.1.150
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
product: MODEL1310110049#

metaR r1604
is described by: ECO:0000000
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
reversible: true
is: SBO:0000185

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR ILEt5m
product: MODEL1310110049#
name: Isoleucine mitochondrial transport
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR r2197
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
fast: false
reactant: MODEL1310110049#
reversible: true

metaR PItg
reactant: MODEL1310110049#
fast: false
type: Reaction
reversible: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: phosphate transport, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR r0386
fast: false
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR r2086
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_2609f5ca_686f_4870_9d4d_8aa51152d63d
boundary condition: true
type: Species
constant: false
name: _H17063_1_c
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:H17063
initial concentration: NaN

metaM sebcoa x
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
constant: false
boundary condition: false
type: Species
has only substance units: false
name: sebacoylcoa
is: HMDB00705
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_f8ee2775_b4b0_4028_b083_5d0c0737a4ed
initial amount: NaN
constant: false
is: O00217
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4728
is: SBO:0000252
type: Species
name: NDUFS8

metaR RE1522M
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1522
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reversible: true
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_c9e491f6_88e3_439d_a750_5dcc27533a20
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: O95573
constant: false
name: ACSL3
is encoded by: hsa:2181
has only substance units: false
is: SBO:0000252

metaR r1603
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM prostgd2 c
type: Species
is: CHEBI:57406
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
name: prostaglandin D2(1-)

metaM tyr L c
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
constant: false
name: L-tyrosine
has only substance units: false
is: CHEBI:17895
is: SBO:0000247
initial concentration: 1.0
is: HMDB00158
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_8fe6a9a2_1050_4f64_857c_6433cd07f758
is encoded by: hsa:4729
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P19404
type: Species
name: NDUFV2

metaR r2196
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110049#

metaR METyLATthc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM c6crn x
name: hexanoyl carnitine
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00705
type: Species
initial amount: NaN
notes: FORMULA: C13H25NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_756de025_f21f_4ee6_a306_ac613dfd4bfd
initial amount: NaN
boundary condition: true
type: Species
name: _LOC728997_1_c
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:LOC728997

http://identifiers.org/biomodels.db/MODEL1310110049#_3db9c21d_11ac_4026_b9e8_5000abc4d905
is encoded by: hsa:23761
constant: false
name: PISD
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9UG56

metaR r2085
type: Reaction
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR NACHEXA11ly
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
fast: false
reversible: false
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9d2441ed_72e7_429a_b8b0_8565d6f08851
constant: false
name: ADCY8
boundary condition: true
initial amount: NaN
is: Q4F7X0
has only substance units: false
is encoded by: hsa:114
type: Species
initial concentration: NaN
is: SBO:0000252

metaM sql r
initial concentration: 1.0
is: CHEBI:15440
is: HMDB00256
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
type: Species
name: squalene
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaR OAGT3tg
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
is: SBO:0000185
name: oagt3 hs intracellular transport
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ

metaM ksi pre34 g
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 34
boundary condition: false
has only substance units: false
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
constant: false
is: C00130
type: Species
initial concentration: 1.0
notes: FORMULA: C241H385N17O202S10X CHARGE: -11

metaR RNDR1
type: Reaction
reversible: false
name: ribonucleoside-diphosphate reductase (ADP)
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#

metaR r0829
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.1.1.37
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction

metaR FRDPtc
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM pacald c
name: phenylacetaldehyde
initial concentration: 1.0
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: SBO:0000247
initial amount: NaN
is: CHEBI:16424
constant: false
boundary condition: false
has only substance units: false
type: Species
is: HMDB06236

metaR r0388
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5

http://identifiers.org/biomodels.db/MODEL1310110049#_e300cd2f_1f75_4523_b091_a677a84bd3fc
initial amount: NaN
is encoded by: hsa:22305
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: _22305_1_c
type: Species
is: SBO:0000252

metaR SQLEr
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
reversible: false
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
name: Squalene epoxidase, endoplasmic reticular (NADP)
is version of: http://identifiers.org/ec-code/1.14.13.132
is described by: ECO:0000134
modifier: MODEL1310110049#
product: MODEL1310110049#

metaR DUMPtn
reversible: true
is: SBO:0000185
product: MODEL1310110049#
name: dUMP nuclear transport
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r1602
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110049#
fast: false
product: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction

metaM prostgd2 e
constant: false
name: prostaglandin D2(1-)
is: CHEBI:57406
initial amount: NaN
is: SBO:0000247
is: HMDB01403
type: Species
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial concentration: 1.0
boundary condition: false

metaR r0509
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110049#

metaM grdp x
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58057
constant: false
name: geranyl diphosphate(3-)
initial concentration: 1.0
initial amount: NaN
is: HMDB01285
has only substance units: false

metaM 4abutn c
name: 4-Aminobutanal
is: C00555
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
is: CHEBI:58264
type: Species
boundary condition: false

metaR B3GNT36g
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM spc hs c
initial concentration: 1.0
name: sphingosylphosphorylcholine
constant: false
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/5311445
has only substance units: false
is: SBO:0000247

metaM hLkynr c
is: HMDB11631
name: 3-hydroxy-L-kynurenine
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: CHEBI:17380
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_9d8deb50_cff3_42ce_a22c_a5a1718a1c25
type: Species
name: NT5M
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9NPB1
initial amount: NaN
is encoded by: hsa:56953

metaR ALAGLNNaEx
fast: false
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reversible: false

metaM 2hb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
is: HMDB00008
boundary condition: false
name: 2-Hydroxybutyrate
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:1148
initial concentration: 1.0
constant: false

metaM h n
constant: false
is: CHEBI:24636
name: proton
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247

metaR HISCAT1
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM ksii core4 pre6 g
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 6
type: Species
constant: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
is: CHEBI:28067
has only substance units: false
initial amount: NaN

metaR r0236
reversible: true
modifier: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
kinetic law: MODEL1310110049#

metaR r2198
is: SBO:0000185
modifier: MODEL1310110049#
type: Reaction
reversible: true
reactant: MODEL1310110049#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110049#

metaM dd2coa m
type: Species
has only substance units: false
is: CHEBI:57330
is: SBO:0000247
is: HMDB03712
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-dodec-2-enoyl-CoA(4-)
boundary condition: false
constant: false
initial amount: NaN

metaR ALAtN1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
fast: false
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110049#
name: Alanine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110049#_ad31c81f_2817_4ea9_b311_256078d9f42b
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:2348
name: FOLR1
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_c110ebc4_6259_4d82_951c_9bdac6796174
constant: false
name: COX7B2
is: SBO:0000252
type: Species
is encoded by: hsa:170712
is: Q8TF08
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r0788
is: SBO:0000176
reversible: true
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_62274e3d_3d20_4034_a019_2d8c3ca1b49c
initial concentration: NaN
name: CHAT
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1103
is: P28329
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_81d70b4c_7378_4169_9763_eaa414c5fc49
initial amount: NaN
boundary condition: true
name: UGT1A8
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:54576
type: Species
is: Q5DSZ6

metaM alpam m
initial amount: NaN
boundary condition: false
name: S-aminomethyldihydrolipoamide
initial concentration: 1.0
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
type: Species
has only substance units: false
is: HMDB06239
constant: false
is: SBO:0000247

metaM h m
boundary condition: false
name: proton
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_f4ac0d77_1c6c_4a5b_9cef_474868a02072
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC7A5
boundary condition: true
is: Q8IV97
has only substance units: false
is encoded by: hsa:8140
type: Species
is: SBO:0000252

metaR r1600
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_18020809_fc63_4ec4_be36_114ef04b3048
is: O95477
initial amount: NaN
is encoded by: hsa:19
has only substance units: false
initial concentration: NaN
name: ABCA1
constant: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_ce780f2b_9ab8_46e4_9e82_a0723278d302
is: SBO:0000252
initial concentration: NaN
is: Q96KH8
has only substance units: false
type: Species
name: SLC6A2
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6530

http://identifiers.org/biomodels.db/MODEL1310110049#_9afc422c_777c_494d_ae16_caf6442a2857
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: Q9NX14
is: SBO:0000252
name: NDUFB11
is encoded by: hsa:54539
has only substance units: false
initial concentration: NaN

metaM 4abutn e
initial amount: NaN
is: HMDB01080
is: CHEBI:58264
has only substance units: false
type: Species
constant: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 4-ammoniobutanal

metaM arachcoa m
boundary condition: false
is: HMDB04258
constant: false
type: Species
name: arachidyl coenzyme A
is: CHEBI:15527
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial concentration: 1.0

metaR r0789
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#

metaM h l
initial amount: NaN
is: C00080
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:24636
boundary condition: false
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: "

metaR r2089
reactant: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_b322fe41_5fd3_4196_9854_71c86a6a5b02
name: ALG8
constant: false
is encoded by: hsa:79053
initial amount: NaN
is: A6NDW6
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaM gpail hs c
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17049
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
has only substance units: false
initial amount: NaN

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_df0663db_3a88_4eb5_a1a5_f5b223337056
initial concentration: NaN
is encoded by: hsa:10317
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: B3GALT5
is: SBO:0000252

metaM 2hb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
constant: false
initial amount: NaN
boundary condition: false
name: 2-Hydroxybutyrate
is: HMDB00008
has only substance units: false
type: Species
is: CHEBI:1148
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_97257cfa_6195_4e8f_83b0_52d362615cf6
boundary condition: true
type: Species
is: P52790
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: HK3
initial concentration: NaN
is encoded by: hsa:3101

http://identifiers.org/biomodels.db/MODEL1310110049#_c40e9376_0bf8_451a_bd2a_f633201bf264
has only substance units: false
is: P32019
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: INPP5B
initial concentration: NaN
is encoded by: hsa:3633
initial amount: NaN

metaM 5hoxindoa c
constant: false
boundary condition: false
name: 5-Hydroxyindoleacetate
type: Species
initial concentration: 1.0
is: CHEBI:27823
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
has only substance units: false
initial amount: NaN
is: HMDB00763
is: SBO:0000247

metaM dd2coa x
is: HMDB03712
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
name: trans-Dodec-2-enoyl-CoA

metaR FUMSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
product: MODEL1310110049#
modifier: MODEL1310110049#
name: Fumarate:sulfite antiport, mitochondrial
reactant: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#
type: Reaction

metaM cdp c
is: SBO:0000247
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: C00112
name: CDP
has only substance units: false
is: HMDB01546
initial amount: NaN

metaR MALtm
reactant: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
fast: false
name: malate transport, mitochondrial
product: MODEL1310110049#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF

metaR r1759
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110049#
is: SBO:0000185
reversible: false
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
name: Y+LAT2 Utilized transport

metaR r0504
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110049#
type: Reaction
reversible: true
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_04522987_c014_4cdf_ba84_1bbb9cea9a7e
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80025
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110049#_4f79cabc_ddde_407e_b92c_c54a1133bb5f
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: NME3
is encoded by: hsa:4832
is: Q13232
is: SBO:0000252

metaR GALGLUSIDEtl
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#
name: galgluside hs intracellular transport
reactant: MODEL1310110049#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_7fcdce60_e494_4bc8_8a38_3307953858bc
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ACAT1
constant: false
is encoded by: hsa:38
type: Species
is: P24752
boundary condition: true
initial concentration: NaN

metaM 3mop m
has only substance units: false
initial amount: NaN
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
is: CHEBI:28654
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
is: HMDB00491
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_ef8393e5_5be8_4daa_b059_4276a0fc0310
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: B3GALT5
is encoded by: hsa:10317
initial amount: NaN

metaM mn l
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
has only substance units: false
type: Species
is: SBO:0000247
name: beta-1,4-mannose-N-acetylglucosamine
boundary condition: false
is: HMDB06535

http://identifiers.org/biomodels.db/MODEL1310110049#_ba92534e_47c5_43bf_8ef4_c90a7b309ab0
name: PPCDC
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:60490
has only substance units: false
constant: false
is: Q96CD2
is: SBO:0000252
type: Species

metaR FUMSO4tm
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
name: Fumarate:sulfate antiport, mitochondrial
reversible: true
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

metaR FAOXC1811603m
modifier: MODEL1310110049#
type: Reaction
name: Beta oxidation fatty acid
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_b1e71baa_9379_4a81_8548_0b65c9ac93a5
boundary condition: true
constant: false
type: Species
is: G5E960
has only substance units: false
is encoded by: hsa:5331
initial concentration: NaN
initial amount: NaN
name: PLCB3
is: SBO:0000252

metaM HC10852 r
has only substance units: false
initial amount: NaN
is: CHEBI:61540
boundary condition: false
is: SBO:0000247
name: palmitoleyl-CoA(4-)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
constant: false
type: Species
initial concentration: 1.0

metaR r0502
is: SBO:0000176
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
fast: false
modifier: MODEL1310110049#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.113
is described by: ECO:0000000

metaR r0679
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
type: Reaction
reversible: true
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR RNDR3
type: Reaction
modifier: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (CDP)
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_cb8c2e4d_ffa0_4010_9ee0_63f71a12af25
constant: false
type: Species
is encoded by: hsa:9194
has only substance units: false
initial amount: NaN
is: Q8NEM3
initial concentration: NaN
boundary condition: true
name: SLC16A7
is: SBO:0000252

metaR FACOAL181i
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
fast: false
name: C181 fatty acid activation
reversible: false
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases

metaM creat c
name: creatine
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00064
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_08fa9164_05d5_4115_9466_6ad413e5f162
is: SBO:0000252
type: Species
boundary condition: true
is: P06576
initial concentration: NaN
is encoded by: hsa:506
name: ATP5B
initial amount: NaN
constant: false
has only substance units: false

metaR OAGT3te
product: MODEL1310110049#
name: oagt3 hs transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_93446a91_29dd_4e5f_b71c_366bb7853754
is encoded by: hsa:137872
initial amount: NaN
is: Q8IWW8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: ADHFE1

metaR S6T5g
reversible: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_a386401d_6459_40fc_afe8_5b47fe47e668
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: A8K7W0
name: VNN2
boundary condition: true
is encoded by: hsa:8875

metaR FK
product: MODEL1310110049#
name: Fucokinase
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.52
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
modifier: MODEL1310110049#

metaR BHBtm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
fast: false
product: MODEL1310110049#
reversible: true
type: Reaction

metaR AG13T9g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110049#
reversible: false
is: SBO:0000176
reactant: MODEL1310110049#
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_0c36ab62_8d03_49b4_b4d9_8a92b777b817
is: SBO:0000252
type: Species
is encoded by: hsa:3098
has only substance units: false
initial amount: NaN
is: B3KXY9
name: HK1
initial concentration: NaN
boundary condition: true
constant: false

metaM HC00664 c
boundary condition: false
type: Species
initial concentration: 1.0
name: D-tagatofuranose 6-phosphate(2-)
is: CHEBI:58695
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_1d304490_ada7_4700_9d28_9320c95fe60d
is: A8K003
name: PMM1
boundary condition: true
is encoded by: hsa:5372
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_7ac8ff8f_4cab_4284_8e22_725a3b0548ed
initial concentration: NaN
name: SLC28A1
is: SBO:0000252
is encoded by: hsa:9154
type: Species
initial amount: NaN
is: O00337
constant: false
has only substance units: false
boundary condition: true

metaM creat e
is: CHEBI:16919
type: Species
is: SBO:0000247
constant: false
name: creatine
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
is: HMDB00064
initial amount: NaN
has only substance units: false

metaR LEUKTRD4t
type: Reaction
name: leukotriene D4 transport
fast: false
reversible: true
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_91d17e6b_f38b_4ef0_bdbe_a19d9590e500
is: SBO:0000252
is encoded by: hsa:6240
initial amount: NaN
name: RRM1
boundary condition: true
is: P23921
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaR ACNAMlt
is described by: ECO:0000269
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
fast: false
kinetic law: MODEL1310110049#
reversible: true
name: N-acetylneuraminate transport into lysososme
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_58b55f78_8c77_4f44_8281_88f24546c18c
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: NDUFV3
is encoded by: hsa:4731
boundary condition: true
constant: false
initial amount: NaN

metaM man6p c
is: CHEBI:17369
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
name: D-Mannose 6-phosphate
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01078
initial amount: NaN
constant: false

metaM c12dc c
name: dodecanedioyl carnitine
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C14143
constant: false
notes: FORMULA: C19H34NO6 CHARGE: -1
is: HMDB04047

metaM h g
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
name: proton
is: CHEBI:24636
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaM 7dhchsterol c
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17759
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
type: Species
initial concentration: 1.0
name: cholesta-5,7-dien-3beta-ol
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_79adc923_270c_45c1_9bbb_2d08eb86614c
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:498
boundary condition: true
has part: P25705
initial concentration: NaN
has only substance units: false
has part: Q6I9V2
constant: false
is encoded by: hsa:509
type: Species

metaM HC02216 c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: CHEBI:28922
type: Species
name: prostaglandin-f2beta
is: SBO:0000247
boundary condition: false

metaM leuktrD4 e
constant: false
is: HMDB03080
name: Leukotriene D4
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:28666
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
type: Species
initial amount: NaN
boundary condition: false

metaM ksii core2 deg8 l
has only substance units: false
type: Species
boundary condition: false
constant: false
is: HMDB00143
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 8
initial concentration: 1.0
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: CHEBI:12936
initial amount: NaN

metaM Ser Gly Ala X Gly l
is: SBO:0000247
initial concentration: 1.0
is: HMDB06202
boundary condition: false
type: Species
notes: FORMULA: XH CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
name: protein-linked serine residue (glycosaminoglycan attachment site)

http://identifiers.org/biomodels.db/MODEL1310110049#_cf3de606_70a6_421b_8a6e_91b354357618
is encoded by: hsa:6533
initial concentration: NaN
name: SLC6A6
has only substance units: false
initial amount: NaN
is: Q9BRI2
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaR FORtr
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: FOR transporter, endoplasmic reticulum
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
reversible: true

metaR ASNNm
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
reversible: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.1.1
product: MODEL1310110049#
is: SBO:0000176
type: Reaction
name: L-asparaginase (mitochondrial)
fast: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000254

metaR PItn
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
name: phosphate transport, nuclear
kinetic law: MODEL1310110049#
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaM c12dc e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C19H34NO6 CHARGE: -1
name: dodecanedioyl carnitine
is: C14143
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB04047

metaR r1609
is described by: ECO:0000000
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110049#

metaR DCMPDA
reactant: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000254
fast: false
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
name: dCMP deaminase
is version of: http://identifiers.org/ec-code/3.5.4.12
product: MODEL1310110049#

metaM h e
is: C00080
is: CHEBI:24636
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton

metaR SO4tl
name: Sulfate transport (lysosome)
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_7d2364bb_72d7_45cd_96be_e07091f9e46f
is: SBO:0000252
is: Q70HW3
has only substance units: false
name: SLC25A26
type: Species
boundary condition: true
is encoded by: hsa:115286
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_d6f47363_3bfd_46e9_a90c_27fa64f411b0
initial concentration: NaN
type: Species
initial amount: NaN
is: O95470
boundary condition: true
is encoded by: hsa:8879
is: SBO:0000252
constant: false
has only substance units: false
name: SGPL1

metaM leuktrD4 c
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:28666
boundary condition: false
has only substance units: false
is: HMDB03080
initial amount: NaN
name: Leukotriene D4
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

http://identifiers.org/biomodels.db/MODEL1310110049#_87f4d3d7_5c8c_44de_8916_5e56326fd87d
initial amount: NaN
name: HMGCS1
constant: false
is encoded by: hsa:3157
is: Q01581
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR AMETr
type: Reaction
is: SBO:0000185
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
name: S-Adenosyl-L-methionine intracellular diffusion
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#

metaR r1608
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM L2aadp6sa c
type: Species
is: CHEBI:17917
initial amount: NaN
name: L-allysine
is: HMDB01263
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false

metaM HC02216 e
initial amount: NaN
is: CHEBI:28922
type: Species
name: prostaglandin-f2beta
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false

metaM cdp e
is: CHEBI:58069
is: SBO:0000247
type: Species
constant: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_e720515c_5819_45fa_a3cb_5d47c27f223f
is encoded by: hsa:1339
name: COX6A2
is: Q02221
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaM 4abutn m
type: Species
constant: false
initial amount: NaN
name: 4-ammoniobutanal
is: HMDB01080
is: CHEBI:58264
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_a4ef229a_3485_4b27_9d61_b0bb946f96f1
boundary condition: true
has only substance units: false
is: Q15758
is encoded by: hsa:6510
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC1A5

metaM m7mpdol L r
is: CHEBI:37636
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20

metaM leugly c
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97364
name: Leucylglycine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_dd1ae227_59bf_45e8_8a45_0084aeebb647
is encoded by: hsa:471
name: ATIC
boundary condition: true
is: P31939
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaR r1607
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110049#

metaM tmndnccoa m
is: SBO:0000247
boundary condition: false
name: timnodonyl coenzyme A
type: Species
has only substance units: false
is: HMDB06514
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0
initial amount: NaN

metaM h c
is: C00080
is: CHEBI:24636
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
boundary condition: false
name: proton
initial amount: NaN

metaR DKMPPD
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)
name: 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
fast: false
is: SBO:0000176

metaM ksii core2 deg5 l
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 5
initial concentration: 1.0
type: Species
notes: FORMULA: C50H82N4O38SX CHARGE: -1

metaR DGULND
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: dehydro-L-gulonate decarboxylase

http://identifiers.org/biomodels.db/MODEL1310110049#_3255364d_bc39_4a7b_9424_c73bed336f99
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:80025
is: SBO:0000252
type: Species
name: PANK2
has only substance units: false
constant: false

metaR r0686
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110049#
modifier: MODEL1310110049#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_7f6ddcac_1b28_4acc_a23b_608792645b05
type: Species
is: Q16720
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:492
boundary condition: true
constant: false
name: ATP2B3

http://identifiers.org/biomodels.db/MODEL1310110049#_0a5a63c4_9be4_4d5a_98cd_f5c4f78db861
name: CMPK1
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: B2R6S5
has only substance units: false
is encoded by: hsa:51727

metaM aacoa c
constant: false
name: Acetoacetyl-CoA
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00332
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
initial concentration: 1.0
is: SBO:0000247

metaR r0791
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110049#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM ksi deg39 l
initial amount: NaN
type: Species
is: CHEBI:12936
is: HMDB00143
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 39
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C48H81N3O36 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110049#_ef4bd3ce_7fd7_42d7_a0f2_9212450bee04
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: PC
initial amount: NaN
is encoded by: hsa:5091
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_29ed11c9_1ce7_422b_bf27_33b8b16c12f2
is encoded by: hsa:26290
initial concentration: NaN
boundary condition: true
constant: false
is: Q9NY28
has only substance units: false
type: Species
initial amount: NaN
name: GALNT8
is: SBO:0000252

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_f61d830c_0499_4fb6_b306_c344b671e260
name: SOD1
constant: false
is: SBO:0000252
is: P00441
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6647
initial amount: NaN

metaR CHLPCTD
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.15
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110049#
fast: false
name: choline phosphate cytididyltransferase

http://identifiers.org/biomodels.db/MODEL1310110049#_3e8db379_0591_49c1_8be1_c272cc8c9b97
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _U37519_1_e
is encoded by: hsa:U37519
constant: false

metaR SERtN1
reactant: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
is described by: ECO:0000269
fast: false
name: Serine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
is: SBO:0000185
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction

metaR RE2649M
name: RE2649
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
reactant: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176

metaM CE2838 e
is: C01936
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
name: maltononaose
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
constant: false
initial concentration: 1.0

metaM cys L c
initial amount: NaN
is: HMDB00574
name: L-cysteine
constant: false
is: CHEBI:17561
initial concentration: 1.0
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_17530602_5888_49fc_a833_9fcedca24580
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79369
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q9C0J1
has only substance units: false
name: B3GNT4

metaR r1760
product: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110049#

metaR ASPNATm
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
name: aspartate N-acetyltransferase, mitochondrial
is described by: ECO:0000000

metaM 3oddcoa m
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:27868
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB03937
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263

http://identifiers.org/biomodels.db/MODEL1310110049#_11787d3b_a90e_485a_a9b0_500ddaa1bfd7
is: P48735
constant: false
name: IDH2
is encoded by: hsa:3418
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaM udpglcur c
constant: false
is: SBO:0000247
type: Species
is: C00167
initial concentration: 1.0
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
boundary condition: false
is: HMDB00935
initial amount: NaN
name: UDP-D-glucuronate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_7e32dca7_9572_48e3_8441_666471b74b1a
type: Species
boundary condition: true
name: NDUFV1
initial concentration: NaN
has only substance units: false
is: E5KNH5
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4723

metaM pyr e
name: pyruvate
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR ASNTHRNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110049#
reversible: false
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_5d96df27_f6e2_4dad_bb21_2f38cb68ef35
is: Q96C36
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29920
name: PYCR2
has only substance units: false
is: SBO:0000252
constant: false

metaR r0683
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3

metaM pyr c
notes: FORMULA: C3H3O3 CHARGE: -1
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
is: HMDB00243
is: SBO:0000247
is: CHEBI:15361
type: Species
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00022
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_9d7e0004_d5e5_427f_a90a_c064e7831427
is: SBO:0000252
initial amount: NaN
name: SLC26A6
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:65010
is: Q548A7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_00b7da5b_705e_4087_919b_2b84f42e9685
constant: false
has only substance units: false
initial concentration: NaN
name: FUT8
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2530
is: B4DFS7
initial amount: NaN

metaM ptrc e
is: CHEBI:326268
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C00134
is: HMDB01414
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_c52a046d_5337_4e3f_846f_eb051427da50
is encoded by: hsa:57134
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q9NR34
type: Species
name: MAN1C1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_93ef4b10_3202_4c50_b0e8_90d135897050
name: ALPPL2
is encoded by: hsa:251
has only substance units: false
constant: false
boundary condition: true
is: P10696
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
constant: false
type: Species
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial amount: NaN
has only substance units: false
name: VI2Fuc-nLc6
is: CHEBI:61648
initial concentration: 1.0
is: SBO:0000247

metaR ADSS
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reactant: MODEL1310110049#
product: MODEL1310110049#
name: adenylosuccinate synthase
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.4
type: Reaction
is described by: ECO:0000134

metaM adp n
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:456216
initial concentration: 1.0
name: ADP(3-)
is: HMDB01341

http://identifiers.org/biomodels.db/MODEL1310110049#_5c5f152b_1b01_4ab7_a308_3bcd67c9bd50
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1798
name: DPAGT1
type: Species
boundary condition: true

metaM ala D c
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
boundary condition: false
is: CHEBI:15570
name: D-alanine
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM ac m
has only substance units: false
boundary condition: false
name: acetate
is: CHEBI:30089
initial concentration: 1.0
is: HMDB00042
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false

metaR ADSL2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000269
name: adenylosuccinate lyase
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
reversible: false
product: MODEL1310110049#

metaR CORE2GTg
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
fast: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR GLYC St
reversible: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
name: L-glycerate export
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR AG13T8g
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110049#

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_7cf361d0_64ef_4699_86c0_41d2abc3ddee
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:205
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: AK4

metaM c6crn e
type: Species
name: hexanoyl carnitine
initial amount: NaN
is: HMDB00705
initial concentration: 1.0
constant: false
notes: FORMULA: C13H25NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR DOLGLCP Lter
type: Reaction
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
is described by: ECO:0000000
is: SBO:0000185

metaM CE0693 m
is: HMDB11123
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
is: SBO:0000247
boundary condition: false

metaR ADSL1
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
name: adenylosuccinate lyase
reversible: false
is version of: http://identifiers.org/ec-code/4.3.2.2
is described by: ECO:0000269
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_da8711d6_4177_4dcc_8a2b_3686046af40c
is: P17516
initial concentration: NaN
is encoded by: hsa:1109
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: AKR1C4
boundary condition: true

metaM adp m
is: http://identifiers.org/pubchem.compound/3310
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01341
is: C00008
is: SBO:0000247
name: ADP
boundary condition: false
is: CHEBI:456216

metaM gpi sig r
is: CHEBI:58190
initial concentration: 1.0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
constant: false
boundary condition: false
notes: FORMULA: Y CHARGE: 0
is: HMDB00224
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_b8c80de4_037a_4b2a_87f0_136c90517c41
boundary condition: true
is: SBO:0000297
has only substance units: false
initial amount: NaN
constant: false
type: Species
has part: Q06055
initial concentration: NaN
is encoded by: hsa:517
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2

metaR GALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
reactant: MODEL1310110049#
fast: false
name: galgluside hs intracellular transport
is described by: ECO:0000000
product: MODEL1310110049#

metaM cdp n
is: CHEBI:58069
is: HMDB01546
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r0688
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
kinetic law: MODEL1310110049#
reversible: true
product: MODEL1310110049#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110049#_afcae493_c466_484d_97c3_70ca0095ec4e
name: PDE8A
constant: false
initial amount: NaN
is encoded by: hsa:5151
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_5b7352a4_9bd7_43f3_be8b_96485efbfa1e
is: O95340
initial amount: NaN
is encoded by: hsa:9060
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PAPSS2
constant: false
type: Species
has only substance units: false

metaR LEUGLYHYc
name: hydrolysis of leucylglycine
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110049#
is: SBO:0000176
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_7980f621_a31d_450e_badd_405f639e4188
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8789
is: SBO:0000252
has only substance units: false
is: O00757
type: Species
constant: false
name: FBP2

http://identifiers.org/biomodels.db/MODEL1310110049#_cc76f18b_e7ca_4f00_b361_4fc7e48efa70
initial amount: NaN
name: IDH1
is encoded by: hsa:3417
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: O75874

metaR GPIMTer L
fast: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
reversible: false
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_f572780e_a4ea_4a5a_aa9b_21ee24524026
constant: false
type: Species
is encoded by: hsa:8818
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: DPM2
is: SBO:0000252

metaR r0937
is: SBO:0000185
reversible: true
fast: false
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ala D e
has only substance units: false
is: HMDB01310
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
boundary condition: false
constant: false
is: SBO:0000247
name: D-alanine
type: Species
initial concentration: 1.0
initial amount: NaN

metaM hmgcoa m
is: SBO:0000247
type: Species
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01375

metaM uri c
initial amount: NaN
is: HMDB00296
type: Species
initial concentration: 1.0
name: Uridine
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
is: C00299

metaM c6crn c
name: hexanoyl carnitine
type: Species
initial concentration: 1.0
is: HMDB00705
initial amount: NaN
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

metaR r0936
reactant: MODEL1310110049#
fast: false
reversible: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_683c8bb9_bd50_459a_ac74_32a6f0dfcba1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10005
type: Species
constant: false
is: O14734
name: ACOT8

metaM acgam1p c
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
boundary condition: false
constant: false
is: HMDB01367
name: N-Acetyl-D-glucosamine 1-phosphate
is: SBO:0000247
is: CHEBI:7125
initial amount: NaN

metaR r1765
modifier: MODEL1310110049#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false

metaR SERASNNaEx
modifier: MODEL1310110049#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is described by: ECO:0000269
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM omhpal c
notes: FORMULA: C16H30O3 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
name: w-hydroxypalmiticacid
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB06294

metaR METLEUex
modifier: MODEL1310110049#
is described by: ECO:0000269
kinetic law: MODEL1310110049#
name: Methionine/Leucine exchange (Met in)
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
is: SBO:0000185
product: MODEL1310110049#

metaR r1467
reversible: true
kinetic law: MODEL1310110049#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110049#

metaR r2090
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
fast: false
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
name: bilirubin transport via bicarbonate countertransport
is: SBO:0000185
is described by: ECO:0000269

metaR UGALGTg
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110049#
type: Reaction
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110049#
is described by: ECO:0000134

metaR BILIRUBtr
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
name: lipid, flip-flop intracellular transport
product: MODEL1310110049#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_0f0b92e2_bf99_459d_a696_fee0bc9315c7
name: SLC20A2
constant: false
type: Species
is: B2RBR4
initial concentration: NaN
is encoded by: hsa:6575
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r1610
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CYANtm
name: Cyanide transport via diffusion (mitochondrial)
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
product: MODEL1310110049#

metaR NODe
kinetic law: MODEL1310110049#
type: Reaction
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: NODe

metaR ARACHDt2
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaR ST8SIA51g
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000269
type: Reaction
reversible: false
product: MODEL1310110049#
is: SBO:0000176

metaR r2091
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_699346ec_aaac_4d05_a772_db51d35f34f0
boundary condition: true
type: Species
is: Q9Y619
name: SLC25A15
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10166

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM uri e
name: Uridine
is: SBO:0000247
is: C00299
is: HMDB00296
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
constant: false

metaM ksi pre23 g
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 23
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: SBO:0000247

metaR DHORTS
fast: false
name: dihydroorotase
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.3.2
is described by: ECO:0000269
modifier: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_575de6db_d470_4a16_8060_7f8f53035957
initial concentration: NaN
type: Species
is: SBO:0000252
is: D3DX95
is encoded by: hsa:1103
initial amount: NaN
has only substance units: false
boundary condition: true
name: CHAT
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_b2ee066f_d36b_4797_86d4_fb8a5f13b727
boundary condition: true
initial amount: NaN
is: B3KVI7
is encoded by: hsa:3712
constant: false
initial concentration: NaN
type: Species
name: IVD
is: SBO:0000252
has only substance units: false

metaR LPCOXp
reactant: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.3.1
product: MODEL1310110049#
name: L-pipecolate oxidase, peroxisomal
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is described by: ECO:0000269
fast: false

metaM rib D c
is: CHEBI:16988
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: D-ribose
is: HMDB00283
constant: false
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_07afbcfc_c102_4687_bd9e_bb1ebe9ef9fd
initial amount: NaN
boundary condition: true
is encoded by: hsa:39
name: ACAT2
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q9BWD1

metaM spc hs e
name: sphingosylphosphorylcholine
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR CYSGLYexR
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
is: SBO:0000185
fast: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
name: L-cysteine/glycine reversible exchanger

http://identifiers.org/biomodels.db/MODEL1310110049#_4566c10b_d762_497c_ae0e_0bc540152142
is: SBO:0000252
is encoded by: hsa:8818
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: DPM2
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_40deec62_d5da_43d6_848e_0b4132071271
initial concentration: NaN
is: Q92947
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:2639
initial amount: NaN
name: GCDH
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_01b50439_46bc_4422_971b_f684b65e6cb4
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:279
initial amount: NaN
is: P04746
name: AMY2A
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_88c2a3cf_ea48_4413_85cb_668d51673636
is: P47989
constant: false
initial amount: NaN
is encoded by: hsa:7498
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: XDH

metaR TSTSTERONEt
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
reversible: true
is described by: ECO:0000269
name: Testosterone transport
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:

metaR r0797
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: glycine N-choloyltransferase EC:2.3.1.65

metaR PIPLC
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false
is described by: ECO:0000000
name: phosphatidylinositol phospholipase C
reversible: false
product: MODEL1310110049#

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR ENGASE2ly
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110049#
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR DASCBR
is described by: ECO:0000269
is: SBO:0000176
name: dehydroascorbate reductase
fast: false
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.8.4.1

metaR r1466
reversible: true
is: SBO:0000176
name: EC:2.3.1.86
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c1b0c25a_f7fa_455b_964f_db89b8ce4ca4
constant: false
initial amount: NaN
is: SBO:0000252
is: Q8TD30
has only substance units: false
is encoded by: hsa:84706
type: Species
boundary condition: true
name: GPT2
initial concentration: NaN

metaR r0796
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reversible: true
reactant: MODEL1310110049#

metaR CITt4 4
is described by: ECO:0000006
name: citrate transport via sodium symport
is: SBO:0000185
reversible: true
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
fast: false

metaR G14T5g
is: SBO:0000176
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110049#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110049#
modifier: MODEL1310110049#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR MM8Cg
kinetic law: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110049#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false

metaR r0381
fast: false
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
kinetic law: MODEL1310110049#
reversible: true
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3

metaR r2095
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110049#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_d0c1d7bf_733c_49d8_9728_d704a1aea549
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q01433
name: AMPD2
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:271

metaM ac e
initial amount: NaN
type: Species
constant: false
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
name: acetate
has only substance units: false
is: SBO:0000247
is: HMDB00042
initial concentration: 1.0
boundary condition: false

metaM rib D e
is: CHEBI:16988
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
name: D-ribose

http://identifiers.org/biomodels.db/MODEL1310110049#_4a1cdd74_a7f4_43ef_8972_8febfc0972a0
initial amount: NaN
has only substance units: false
is: P45954
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:36
name: ACADSB
constant: false
boundary condition: true

metaM 7dhchsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:17759
name: cholesta-5,7-dien-3beta-ol
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00032

metaR ADSK
type: Reaction
name: adenylyl-sulfate kinase
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
fast: false
reactant: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.25
modifier: MODEL1310110049#
is: SBO:0000176

metaR CHSTEROLt3
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
name: cholesterol intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_7d456e89_7520_438f_86b1_548b45a71ae1
has only substance units: false
is encoded by: hsa:10455
is: SBO:0000252
constant: false
name: ECI2
boundary condition: true
is: O75521
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_bd963d6f_8682_4514_b511_f51f4800d287
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8527
name: DGKD
type: Species
boundary condition: true
constant: false

metaM cys L e
name: L-cysteine
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00574
has only substance units: false
is: CHEBI:17561
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099

metaR HMGCOASim
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
kinetic law: MODEL1310110049#
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)

metaR r1464
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110049#_30a358ac_bdaa_4c7b_bb50_a4b6304c0f56
is: SBO:0000252
is: P04183
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: TK1
is encoded by: hsa:7083
boundary condition: true

metaR r2096
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110049#_cfb98e1d_d4fa_4bdd_b01f_fd70ff2a4aee
type: Species
boundary condition: true
is: P07864
name: LDHC
has only substance units: false
initial amount: NaN
is encoded by: hsa:3948
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_adae8d1d_d76a_4c9d_9ca9_0134944221e0
is: Q01968
type: Species
boundary condition: true
is: SBO:0000252
name: OCRL
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:4952

metaM mi14p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
is: CHEBI:58282
is: SBO:0000247
is: HMDB00968
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_718223d5_d3bf_41a4_90a7_04bfe8f123e7
initial amount: NaN
name: PCBD1
type: Species
initial concentration: NaN
has only substance units: false
is: P61457
constant: false
is encoded by: hsa:5092
is: SBO:0000252
boundary condition: true

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_7604fac9_a9d4_4660_98af_89a88fbaca35
is: SBO:0000252
is encoded by: hsa:124935
name: SLC43A2
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q8N370

metaR MI3PP
is: SBO:0000176
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
fast: false
name: myo-inositol 3-phosphatase
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.25
reversible: false

metaR MI145PK
name: inositol-1,4,5-trisphosphate 3-kinase
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
product: MODEL1310110049#
is described by: ECO:0000269
kinetic law: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.127
reactant: MODEL1310110049#
is: SBO:0000176
fast: false
type: Reaction

metaM g3m8mpdol U r
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
constant: false
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: C05873

metaR r2093
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#

metaR NDPK2n
kinetic law: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true

metaR SARDHm
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
reversible: false
name: Sarcosine dehydrogenase (m)
type: Reaction
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.5.99.1

metaM c12dc x
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H34NO6 CHARGE: -1
initial amount: NaN
constant: false
is: HMDB00705
name: dodecanedioyl carnitine
type: Species
boundary condition: false

metaM ac c
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:30089
name: acetate
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
constant: false

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_df728bd8_4c20_422f_aac5_736d097edaa8
has only substance units: false
constant: false
boundary condition: true
name: B3GNT8
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:374907
is: SBO:0000252

metaR r0680
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.137

metaR DM gpi sig er
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR PNTEH
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.1.92
kinetic law: MODEL1310110049#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
type: Reaction
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000269
name: Hydrolase Class ( RXN R02973)
product: MODEL1310110049#

metaM HC02020 r
name: Cholesterol-ester-palm
constant: false
initial amount: NaN
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:3663
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_755655e7_3a47_453e_95ec_a8bd40896f59
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55163
name: PNPO
constant: false
initial concentration: NaN
is: Q9NVS9
has only substance units: false
type: Species
boundary condition: true

metaR r2092
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110049#

metaR CHSTEROLt1
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
is: SBO:0000185
type: Reaction
name: cholesterol intracellular transport
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110049#

metaR r2094
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true

metaR TRIODTHYt2
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
name: T3 transport via facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
modifier: MODEL1310110049#
reversible: true
is described by: ECO:0000269

metaR NACHEXA19ly
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110049#

metaR NDPK2m
modifier: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254
fast: false
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#

metaM hxcoa x
type: Species
has only substance units: false
name: Hexanoyl-CoA (n-C6:0CoA)
boundary condition: false
is: HMDB00705
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM adp c
initial amount: NaN
name: ADP
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3310
constant: false
is: HMDB01341
is: CHEBI:16761
initial concentration: 1.0
boundary condition: false
is: C00008
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_34ecf2d2_c03d_4f74_9bba_2cd1b51c50f7
name: HK1
type: Species
boundary condition: true
is: P78542
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3098
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_f2977bdc_0c28_47d8_b2e0_f51b5fd0b606
boundary condition: true
is encoded by: hsa:HG2846-HT2983
is: SBO:0000252
type: Species
constant: false
name: _HG2846_HT2983_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c36d9543_4b00_481f_8536_696762a570d0
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6484
name: ST3GAL4
type: Species
is: Q6IBE6
is: SBO:0000252

metaR CHOLt4
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
name: choline, sodium cotransport
reactant: MODEL1310110049#
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110049#
type: Reaction
is: SBO:0000185

metaR r0792
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110049#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR CHSTEROLt2
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: cholesterol intracellular transport
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_f9505079_4134_4921_bf04_78b837266072
constant: false
name: _2544_1_c
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:2544
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_78f0a166_6676_4080_92d7_86c5f153dae3
name: NANS
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:54187
initial amount: NaN
boundary condition: true
is: Q9NR45
has only substance units: false
type: Species

metaM 34dhmald m
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903
has only substance units: false
is: HMDB06242
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: C05577
is: SBO:0000247
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577

metaR NTD3
product: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
name: 5'-nucleotidase (dCMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false

metaM nadp r
is: HMDB00217
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
is: SBO:0000247

metaR r2098
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110049#_4b6563e2_ee12_4b3b_8fb6_7165936bf58d
boundary condition: true
is encoded by: hsa:3073
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: P06865
name: HEXA
has only substance units: false

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR OLEICFATPtc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM uri n
is: HMDB00296
initial amount: NaN
constant: false
name: uridine
has only substance units: false
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
is: CHEBI:16704
boundary condition: false
initial concentration: 1.0

metaR DOLASNT Uer
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.119
is described by: ECO:0000000
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_939b93bf_9eb1_4529_9969_70b881fe6cc1
has only substance units: false
name: NDUFB1
initial concentration: NaN
boundary condition: true
is: O75438
is encoded by: hsa:4707
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_a7265902_b507_4482_9e23_3f4ec8ceb53f
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110049#_f6ba68c8_8c05_43af_aecc_422791119670
boundary condition: true
has only substance units: false
has part: P56381
is encoded by: hsa:514
initial concentration: NaN
has part: P30049
initial amount: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
type: Species
constant: false
has part: A8K092
is encoded by: hsa:498
is encoded by: hsa:513
has part: P06576
is encoded by: hsa:509
is: SBO:0000297
has part: P36542
is encoded by: hsa:506

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR CSCPASEly
kinetic law: MODEL1310110049#
reversible: false
name: chondroitin sulfate C proteoglycan protease, lysosome (endosome)
product: MODEL1310110049#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#

metaR B3GNT35g
is: SBO:0000176
type: Reaction
reactant: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110049#
is described by: ECO:0000269
kinetic law: MODEL1310110049#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110049#

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR RETFA
is: SBO:0000176
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: retinol acyltransferase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
reversible: false

metaR r2097
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false

metaR GGH 6DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6DHF), extracellular
modifier: MODEL1310110049#
reversible: false
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR FAOXC14C12x
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR IDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
name: IDP nuclear transport

metaM uri m
initial amount: NaN
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
is: HMDB00296
is: SBO:0000247
name: uridine
has only substance units: false
boundary condition: false
is: CHEBI:16704
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_22529f37_4c70_49e4_8209_ed17288de1f1
is: Q0VAA5
constant: false
name: PLCXD2
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:257068
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR NTD5
reversible: false
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
name: 5'-nucleotidase (dTMP)
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134
is: SBO:0000176

metaR NTD6
product: MODEL1310110049#
name: 5'-nucleotidase (dAMP)
is: SBO:0000176
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
fast: false
kinetic law: MODEL1310110049#

metaR NOt
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
product: MODEL1310110049#
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000
type: Reaction
name: NO transport (diffusion)

metaR ASNCYSNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
modifier: MODEL1310110049#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
fast: false

metaM C02528 r
is: HMDB00518
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
boundary condition: false
initial amount: NaN
is: CHEBI:36234
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM m4mpdol L c
boundary condition: false
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:37633
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_d31e0975_48a4_4875_9565_5f4fb97f6805
name: PYCR1
initial concentration: NaN
type: Species
is encoded by: hsa:5831
is: SBO:0000252
is: P32322
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR RE1521M
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110049#
fast: false
name: RE1521
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaM ksii core2 pre5 g
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 5
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00175
has only substance units: false
is: C00130
is: CHEBI:58053
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_aac454cd_8111_404f_a61c_f2cd9dcd0368
initial amount: NaN
is: Q02218
type: Species
is encoded by: hsa:4967
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: OGDH
constant: false

metaM 5hoxindact c
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
boundary condition: false
constant: false
name: (5-hydroxyindol-3-yl)acetaldehyde
is: HMDB04073
initial concentration: 1.0
initial amount: NaN
is: CHEBI:50157

metaR r2099
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_daf7e237_b85f_4b0b_b4ee_63693e78d0a4
is: SBO:0000252
is: O60547
type: Species
boundary condition: true
name: GMDS
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2762

metaR MI1345PP
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
type: Reaction
product: MODEL1310110049#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD

metaR Rtotaltl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
reversible: true
name: fatty acid intracellular transport
fast: false
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaM dc2coa m
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
has only substance units: false
initial amount: NaN
boundary condition: false
name: trans-Dec-2-enoyl-CoA
initial concentration: 1.0
is: CHEBI:61406

metaM Ssq23epx r
type: Species
boundary condition: false
is: CHEBI:15441
is: SBO:0000247
name: (S)-2,3-epoxysqualene
initial concentration: 1.0
constant: false
is: HMDB01188
has only substance units: false
initial amount: NaN
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054

http://identifiers.org/biomodels.db/MODEL1310110049#_99b447ac_8b57_4b5d_a164_72da6a61642b
constant: false
is encoded by: hsa:5335
initial concentration: NaN
is: SBO:0000252
type: Species
is: P19174
name: PLCG1
initial amount: NaN
boundary condition: true
has only substance units: false

metaR CHOLATEt
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269
name: cholate transport via bicarbonate countertransport
fast: false
modifier: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_a9d31bab_7e92_46ef_b2be_ad57faf447a3
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC26A7
constant: false
initial concentration: NaN
is encoded by: hsa:115111
is: Q8TE54
boundary condition: true
has only substance units: false

metaR RE3001M
is version of: http://identifiers.org/ec-code/1.3.1.34
reversible: true
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: RE3001
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110049#

metaR ADK3m
is described by: ECO:0000269
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.10
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
product: MODEL1310110049#
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110049#
name: adentylate kinase (GTP)
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_a0317fc3_f10f_4076_8450_bbb8ea9f29f0
is: P00338
initial concentration: NaN
type: Species
constant: false
name: LDHA
initial amount: NaN
is encoded by: hsa:3939
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_ffb6c3ef_9778_4246_bf3c_6ff1842ce83c
constant: false
boundary condition: true
name: AK5
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9Y6K8
is encoded by: hsa:26289
type: Species

metaR DINt
is described by: ECO:0000000
name: deoxyinosine transport via diffusion
product: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
fast: false
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_e268363b_4637_434d_8405_d17a73f1b06a
type: Species
is encoded by: hsa:386757
is: SBO:0000252
name: SLC6A10P
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaR LYStn
product: MODEL1310110049#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: L-lysine transport, nuclear
is described by: ECO:0000000

metaR NTD8
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110049#
name: 5'-nucleotidase (dGMP)
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_7bd824f4_9fd9_454b_ae01_4488fcea7ebc
name: SLC5A8
is: Q8N695
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:160728
boundary condition: true
type: Species

metaM dopasf c
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:37946
constant: false
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
boundary condition: false
is: HMDB06275
name: dopamine 3-O-sulfate

http://identifiers.org/biomodels.db/MODEL1310110049#_1070c0d8_e6d4_4ae5_a70e_695fb1fa2a11
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI091231
initial concentration: NaN
initial amount: NaN
name: _AI091231_1_c
boundary condition: true
constant: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_2b570b69_6fd1_4cbf_8d26_c8b4d3df654f
is: Q8N5Z0
name: AADAT
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51166
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR RE2269E
kinetic law: MODEL1310110049#
reversible: true
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.4.21.39
name: RE2269
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:

metaR r0226
type: Reaction
reversible: false
reactant: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_1924c994_b183_4b9c_be4d_e6a88a592054
constant: false
is encoded by: hsa:5860
initial amount: NaN
type: Species
is: P09417
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: QDPR

metaR HEXDICOAACBPx
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_92f11eeb_4aa1_4476_be56_41a0be6ac6be
is: O15269
is encoded by: hsa:10558
has only substance units: false
name: SPTLC1
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_3c906e37_a95a_49a5_a626_f0af383b54b5
is encoded by: hsa:10632
boundary condition: true
type: Species
is: O75964
name: ATP5L
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM ebastineoh c
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:17625
name: hydroxylated ebastine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C32H39NO3 CHARGE: 0
is: HMDB01191
boundary condition: false

metaR NMNS
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110049#
reversible: false
fast: false
product: MODEL1310110049#
name: NMN synthetase
reactant: MODEL1310110049#

metaM nadp x
constant: false
is: C00006
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
boundary condition: false
is: CHEBI:58349
is: HMDB00217
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_ac9e5a52_81f8_47aa_8198_157cb0e144c6
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q5JT09
is encoded by: hsa:83549
name: UCK1

metaR S6T6g
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110049#

metaR SBTR
kinetic law: MODEL1310110049#
type: Reaction
reversible: false
name: D-sorbitol reductase
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
is described by: ECO:0000269
modifier: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110049#
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_5cecd713_fa63_4d7c_aec5_b8960091bf62
is: SBO:0000252
is encoded by: hsa:109
initial concentration: NaN
name: ADCY3
boundary condition: true
is: B3KT86
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaR ITPtn
kinetic law: MODEL1310110049#
name: ITP nuclear transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110049#
reversible: true
fast: false
type: Reaction
product: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_5856f2c9_e5f4_48f6_990f_8bd0e950ba0f
name: TUSC3
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7991
type: Species
has only substance units: false

metaM paps c
is: HMDB01134
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM ksii core4 pre5 g
is: SBO:0000247
is: C00130
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 5
notes: FORMULA: C69H112N6O48X CHARGE: -1

metaR O16G2e
fast: false
is: SBO:0000176
modifier: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.10
name: oligo-1,6-glucosidase (strch2 ->strch3), extracellular
product: MODEL1310110049#
reactant: MODEL1310110049#

metaM dopasf e
is: SBO:0000247
name: dopamine 3-O-sulfate
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:37946
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_b1738225_e727_4307_a401_7e122b1423fd
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:8803
initial concentration: NaN
has part: E5KS60
is: SBO:0000297
name: SUCLG1:SUCLA2
has only substance units: false

metaM ksii core2 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
boundary condition: false
is: C00130
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00175

metaR r0817
is described by: ECO:0000000
modifier: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM spmd c
is: HMDB01257
is: C00315
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Spermidine
boundary condition: false
is: CHEBI:57834

metaM pap c
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
is: SBO:0000247
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061

metaR DNDPt8m
type: Reaction
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reversible: false
name: dADP transport via dUDP antiport
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_4656241a_5b3a_496d_b2d6_94a59e16fc55
is: P16442
is encoded by: hsa:28
name: ABO
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR BIOCYTtn
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
is: SBO:0000185
name: biocytin transport, nuclear
product: MODEL1310110049#

metaR GCC2cm
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
product: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false

metaR r0377
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
product: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
modifier: MODEL1310110049#
is: SBO:0000176
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74

metaM tchola x
type: Species
name: taurocholate
is: HMDB00036
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:36257
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_41002d8f_029e_4938_91ef_ac88025d220e
is: SBO:0000252
initial amount: NaN
name: PIGF
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: Q07326
type: Species
is encoded by: hsa:5281

http://identifiers.org/biomodels.db/MODEL1310110049#_bf253126_a3da_4039_a5c6_9bed73c93f54
constant: false
is: P21108
is encoded by: hsa:221823
has only substance units: false
name: PRPS1L1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_2436acdb_7cc4_4e78_b542_7f521fd128fc
constant: false
is encoded by: hsa:3945
has only substance units: false
boundary condition: true
is: P07195
type: Species
name: LDHB
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR SARCStm
fast: false
is described by: ECO:0000000
name: Sarcosine transport (mitochondrial)
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110049#
type: Reaction

metaR r0514
reversible: false
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
reactant: MODEL1310110049#

metaM omhpal r
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06294
has only substance units: false
notes: FORMULA: C16H30O3 CHARGE: -1
name: w-hydroxypalmiticacid
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_1d473ae8_20b2_49cc_a68e_87ddc0af1e5e
constant: false
initial amount: NaN
is encoded by: hsa:6240
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:6241
name: RRM1:RRM2
has part: P31350
has part: P23921
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110049#_3c7bec8f_7093_4d8e_80fd_2510f9a5140f
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4718
name: NDUFC2
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: Q549M5

metaR DOLPGT1 Uer
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.267
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
type: Reaction
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000

metaR PPCDC
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
name: phosphopantothenoylcysteine decarboxylase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_0b541d38_769b_4946_b8a2_79a10bf1fc00
initial concentration: NaN
has only substance units: false
name: HMGCL
constant: false
boundary condition: true
initial amount: NaN
is: Q6IBC0
type: Species
is: SBO:0000252
is encoded by: hsa:3155

metaM pyr m
is: http://identifiers.org/pubchem.compound/3324
constant: false
is: C00022
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00243
is: CHEBI:15361
type: Species

metaR NACHEXA12ly
type: Reaction
modifier: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110049#
product: MODEL1310110049#

metaM ksii core4 deg2 l
is: HMDB00143
name: keratan sulfate II (core 4-linked), degradation product 2
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_b083e91b_252e_43b5_b1ea_44d0b04ecbf0
name: ACSS3
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: Q9H6R3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:79611
boundary condition: true

metaR FACOAL180i
reversible: false
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110049#
fast: false
name: C180 fatty acid activation
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_1863ad30_d177_4a6a_836e_766924c69ac5
has only substance units: false
is encoded by: hsa:8694
initial concentration: NaN
boundary condition: true
is: O75907
constant: false
initial amount: NaN
type: Species
name: DGAT1
is: SBO:0000252

metaM paps g
constant: false
is: HMDB01134
is: SBO:0000247
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: CHEBI:58339
type: Species
initial concentration: 1.0

metaM Lpipecol x
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: L-pipecolic acid
is: HMDB00716
constant: false
is: SBO:0000247
is: CHEBI:30913
initial amount: NaN

metaR r0926
reversible: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110049#
name: Postulated transport reaction
fast: false
is: SBO:0000185

metaM c226crn c
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: http://identifiers.org/pubchem.compound/127055
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB06510
is: SBO:0000247
name: cervonyl carnitine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_08a25210_beec_4bd7_a00f_7810779d852c
initial amount: NaN
is: SBO:0000252
is: P11310
name: ACADM
has only substance units: false
type: Species
is encoded by: hsa:34
constant: false
boundary condition: true
initial concentration: NaN

metaR SPHS1Pte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
name: sphingosine-1-phosphate transport
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110049#
reversible: true

metaR 34DHPLACOX
reversible: false
is described by: ECO:0000269
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_d52a0aca_1f32_423c_aa2a_a737cfb6c7ec
is encoded by: hsa:8527
is: Q16760
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: DGKD
constant: false

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM acnam l
is: CHEBI:35418
initial concentration: 1.0
name: N-acetylneuraminate
type: Species
is: SBO:0000247
is: HMDB00230
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_29bfd542_3890_4a59_a7db_366a03756c15
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:728226
is: SBO:0000252
initial amount: NaN
name: _728226_1_e
boundary condition: true

metaM 34dhmald c
is: C05577
has only substance units: false
is: http://identifiers.org/pubchem.compound/7903
is: SBO:0000247
is: HMDB06242
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaM ebastineoh e
is: CHEBI:17625
name: hydroxylated ebastine
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C32H39NO3 CHARGE: 0
is: HMDB01191

metaM imp c
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: IMP
is: CHEBI:58053
is: C00130
is: HMDB00175
has only substance units: false

metaR NAGLCAly
fast: false
type: Reaction
product: MODEL1310110049#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
name: N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD

metaR GALASE6ly
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
fast: false

metaM tym c
name: tyraminium
initial concentration: 1.0
is: CHEBI:327995
is: HMDB00306
type: Species
constant: false
boundary condition: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_53476a63_9997_4c33_a69c_6067c11e785e
type: Species
constant: false
is: P17752
is: SBO:0000252
name: TPH1
initial concentration: NaN
is encoded by: hsa:7166
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d9c95cc6_5a79_47c6_8154_0724434eba3c
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: _H77542_1_c
is encoded by: hsa:H77542
boundary condition: true
initial concentration: NaN

metaR ARAB Lt
reversible: true
kinetic law: MODEL1310110049#
name: L-arabinoase extracellular transport
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction

metaM pap g
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
has only substance units: false
is: HMDB00061
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58343
constant: false
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_76058a51_10cc_474e_b388_688ac748237e
initial amount: NaN
name: SYNJ1
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:8867
initial concentration: NaN
is: C9JFZ1
is: SBO:0000252
type: Species

metaR r0517
is: SBO:0000176
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110049#
modifier: MODEL1310110049#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
is described by: ECO:0000000
reversible: true

metaM r5p c
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
constant: false
is: CHEBI:18189
is: HMDB00618
initial amount: NaN
name: alpha-D-Ribose 5-phosphate
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00117

metaR HMGCOAtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
reactant: MODEL1310110049#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110049#_edf0bd8a_2455_45ac_bacb_d889aa107437
type: Species
constant: false
has only substance units: false
name: B4GALT5
is encoded by: hsa:9334
is: O43286
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM nadp m
initial concentration: 1.0
is: CHEBI:58349
is: SBO:0000247
is: HMDB00217
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
has only substance units: false
type: Species
name: Nicotinamide adenine dinucleotide phosphate
constant: false

metaM xylu L c
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: CHEBI:17399
initial concentration: 1.0
is: HMDB00751
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: L-xylulose
has only substance units: false

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false

metaM 10fthf c
initial amount: NaN
is: HMDB00972
is: CHEBI:57454
boundary condition: false
is: C00234
constant: false
has only substance units: false
name: 10-Formyltetrahydrofolate
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

http://identifiers.org/biomodels.db/MODEL1310110049#_b5587d4e_71da_4458_815e_7165d807a60d
name: PPA2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: F8WDN9
boundary condition: true
initial amount: NaN
is encoded by: hsa:27068
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_ea4a8376_b739_4f03_896d_a1955576f977
name: ACAD9
constant: false
is encoded by: hsa:28976
boundary condition: true
is: SBO:0000252
type: Species
is: Q9H845
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM ksi pre15 g
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 15
is: HMDB00175
is: CHEBI:58053
is: C00130
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_ae6aba4b_01cc_44bf_abb1_bd02683bcb30
name: ALDH4A1
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8659

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR HDCAtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110049#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110049#

metaM prpncoa m
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
name: acryloyl-CoA(4-)
is: CHEBI:57367
type: Species
is: HMDB02307
initial concentration: 1.0

metaR S2L2FN2M2MASNtly
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110049#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: s2l2fn2m2masn transport, extracellular to lysosome

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM dcholcoa c
has only substance units: false
name: chenodeoxycholoyl coenzyme a
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
initial concentration: 1.0
is: HMDB06292

metaR r0512
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110049#
type: Reaction
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM c4crn m
is: SBO:0000247
is: HMDB02013
is: C02862
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false
name: butyryl carnitine
is: http://identifiers.org/pubchem.compound/213144

metaR DOLDPP Ler
fast: false
type: Reaction
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
is version of: http://identifiers.org/ec-code/3.6.1.43
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
reversible: false
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_615f3a52_1939_455b_beff_868e146d08e2
is encoded by: hsa:9468
constant: false
has only substance units: false
initial amount: NaN
is: E9PD84
initial concentration: NaN
type: Species
name: PCYT1B
boundary condition: true
is: SBO:0000252

metaR RE3624M
is: SBO:0000176
fast: false
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110049#
name: RE3624
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_b4d30881_e626_442a_be85_1c38e809232c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:55229
is: Q9NVE7
name: PANK4
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_f5a1fb98_d61f_450e_9429_6b7b2a3d55b4
is: E9PHN8
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:9843
initial concentration: NaN
name: HEPH
initial amount: NaN

metaR NTD1
is: SBO:0000176
name: 5'-nucleotidase (dUMP)
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110049#_286277bd_e2e0_4984_b2da_19d2a39b7a37
name: CHKA
is: SBO:0000252
is encoded by: hsa:1119
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ce3f75b0_1c8c_4f76_8803_5d7eef3d8bc4
type: Species
name: GGT7
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:2686
is: SBO:0000252
boundary condition: true
is: A0PJJ9

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaM clpndcoa x
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
is: C16166
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205476
is: HMDB06267
constant: false
name: clupanodonyl CoA

metaR FADH2tru
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110049#
name: FADH2 transporter, endoplasmic reticulum
reactant: MODEL1310110049#
fast: false

metaR NCKt
fast: false
name: Na+/Ca2+-K+ exchange
type: Reaction
kinetic law: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
product: MODEL1310110049#
modifier: MODEL1310110049#

metaM prostgh2 c
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57405
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
type: Species
is: HMDB01381

metaM nadp c
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
is: C00006
has only substance units: false
is: CHEBI:58349
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_4fd4deb9_5fe7_4d93_8d08_6a5ee99f1776
is: Q6FG42
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: NDUFA7
initial concentration: NaN
is encoded by: hsa:4701
boundary condition: true

metaR PIt7
modifier: MODEL1310110049#
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
fast: false
reversible: true
is: SBO:0000185

metaR CSNAT2m
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
type: Reaction
reactant: MODEL1310110049#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
is described by: ECO:0000000
name: carnitine O-aceyltransferase, mitochondrial
modifier: MODEL1310110049#
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_4064ec9b_a5da_417d_8416_e44c86e33f95
initial concentration: NaN
is: Q9UBX3
name: SLC25A10
is: SBO:0000252
is encoded by: hsa:1468
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_4795fbb3_9592_4d35_8680_0af62db116e7
is encoded by: hsa:10449
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: ACAA2
initial concentration: NaN
is: SBO:0000252
is: P42765
boundary condition: true

metaM ha deg1 l
constant: false
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: hyaluronan degradation product 1
is: SBO:0000247
initial amount: NaN

metaR RETNt
product: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reactant: MODEL1310110049#
name: retinoic acid transport
is described by: ECO:0000000
fast: false

metaM em2emgacpail hs r
has only substance units: false
constant: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
type: Species
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
is: CHEBI:16240
is: HMDB03125
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_c0e40ff5_1bb4_46b6_9646_a41d3b8d4ef7
is encoded by: hsa:1607
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: DGKB
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#
name: blood group intracellular transport
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_f7d79df2_1b00_40cc_9342_beb0f8156682
boundary condition: true
initial concentration: NaN
name: PECR
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55825
type: Species
is: Q9BY49
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_15edcc72_ced0_4271_bff6_efa1cb10614d
is: SBO:0000252
has only substance units: false
type: Species
is: P51178
name: PLCD1
is encoded by: hsa:5333
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_ca7f4526_483d_4777_828d_815c4c2cf514
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: COX7A1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1346
constant: false
is: P24310

http://identifiers.org/biomodels.db/MODEL1310110049#_0ea0acb2_5ea2_4410_ba31_807351f7e8f5
name: B3GALNT1
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O75752
boundary condition: true
is encoded by: hsa:8706
constant: false

metaM C02528 c
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:36234
is: HMDB00518
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ddfe9409_33d5_478c_8a39_73c298f3b812
is encoded by: hsa:AI971036
boundary condition: true
name: _AI971036_1_m
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r0698
fast: false
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
type: Reaction
reactant: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.1.2.27
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110049#
is described by: ECO:0000000

metaM 5adtststerone r
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
constant: false
is: CHEBI:16330
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one

metaM udpacgal g
boundary condition: false
is: CHEBI:57847
type: Species
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_eb8744f3_ae1e_48f9_a232_6a4ddc6fae67
name: NDUFA4
is: O00483
has only substance units: false
initial amount: NaN
is encoded by: hsa:4697
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_8505bc56_1836_4c18_9535_f2b21d4887b9
boundary condition: true
initial amount: NaN
name: _AI935189_1_m
is encoded by: hsa:AI935189
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ea3ad38e_04ab_445c_8432_c5f24949e757
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10195
name: ALG3
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d9cbe353_1073_427a_a17a_62a577cbecd3
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:3081
name: HGD
initial amount: NaN
is: Q93099
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_532587cc_66b6_4111_a9a0_a62e7afa0fbd
is encoded by: hsa:AA854479
constant: false
type: Species
name: _AA854479_1_m
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM prostgd2 r
type: Species
initial amount: NaN
name: prostaglandin D2(1-)
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01403

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_ebe3e7dc_78e4_411d_acf8_0550a6b051b4
initial amount: NaN
is: Q13423
is encoded by: hsa:23530
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NNT
constant: false
type: Species

metaR PIt8
fast: false
is: SBO:0000185
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
name: phosphate transport in/out via Na+ symporter
reversible: true
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110049#_a72c7f74_66bc_44a8_8fb3_825169cf6b79
constant: false
is encoded by: hsa:2731
boundary condition: true
is: SBO:0000252
is: P23378
type: Species
name: GLDC
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR C226COAtx
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_7c10e01e_32b5_44dd_9f05_b22edbef17c7
initial amount: NaN
is encoded by: hsa:5297
name: PI4KA
boundary condition: true
is: B4DYG5
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaM 10fthf e
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
is: HMDB00972
is: CHEBI:57454
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaM nm2masn g
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: C05884

metaM 10fthf m
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00972
name: 10-formyltetrahydrofolate(2-)
type: Species
has only substance units: false
initial amount: NaN

metaR FE3MTP1
is: SBO:0000185
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110049#
name: transport of ferrous iron into blood
reversible: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#

metaR URIt
name: uridine facilated transport in cytosol
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaR MG2er
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110049#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

metaR IPDDIx
is version of: http://identifiers.org/ec-code/5.3.3.2
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
fast: false
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110049#

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR NADPtru
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: false
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: NADP transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_53f4a122_174b_4945_a9c7_d88bc403dc6e
has only substance units: false
is encoded by: hsa:8574
name: AKR7A2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: O43488
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_fdc561ad_fb7a_438e_91a4_659d846b841e
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:762
initial amount: NaN
is: Q6FHI7
is: SBO:0000252
constant: false
name: CA4
initial concentration: NaN

metaR HMGCOAtm
type: Reaction
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
is: SBO:0000185
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
product: MODEL1310110049#
is described by: ECO:0000000

metaM ebastineoh r
type: Species
boundary condition: false
is: CHEBI:17625
initial amount: NaN
is: HMDB01191
has only substance units: false
notes: FORMULA: C32H39NO3 CHARGE: 0
is: SBO:0000247
name: hydroxylated ebastine
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_f013a69d_ade1_4e1a_b2bf_dd21e5de5ee1
initial amount: NaN
is encoded by: hsa:6528
is: Q92911
has only substance units: false
type: Species
boundary condition: true
name: SLC5A5
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_c8850d39_8c77_4242_b490_e3db50aaf8e4
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: B3GNT1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11041
is: O43505

http://identifiers.org/biomodels.db/MODEL1310110049#_ed94c341_104d_4b4d_8a02_f49481a3fb93
constant: false
is encoded by: hsa:5137
name: PDE1C
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: Q8NB10
initial concentration: NaN

metaM c4crn c
initial amount: NaN
is: C02862
is: HMDB02013
notes: FORMULA: C11H21NO4 CHARGE: 0
constant: false
type: Species
name: butyryl carnitine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false

metaM pro D e
is: CHEBI:16313
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: HMDB03411
constant: false
boundary condition: false
name: D-proline
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_f611072e_ca46_4850_9f28_f51dc05032be
initial concentration: NaN
name: GALNS
boundary condition: true
is encoded by: hsa:2588
is: SBO:0000252
type: Species
is: P34059
has only substance units: false
constant: false
initial amount: NaN

metaR DHAAt1r
reversible: true
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000269
fast: false
name: dehydroascorbate transport (uniport)

http://identifiers.org/biomodels.db/MODEL1310110049#_2f9490f1_e68e_4f96_b849_4389ace76b15
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI222095
boundary condition: true
is: SBO:0000252
name: _AI222095_1_e
has only substance units: false
constant: false
type: Species

metaM prostgh2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
is: CHEBI:57405
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01381
has only substance units: false
constant: false
boundary condition: false
name: prostaglandin H2(1-)

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_06919834_2a52_4152_a552_94bf8c4a62b8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFA10
constant: false
is: O95299
initial amount: NaN
type: Species
is encoded by: hsa:4705

http://identifiers.org/biomodels.db/MODEL1310110049#_5a5bb5cb_cdf3_4bf1_878e_67d542bf0f36
initial amount: NaN
is encoded by: hsa:5151
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PDE8A
type: Species

metaR SRTNt6 2 r
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
type: Reaction
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
modifier: MODEL1310110049#
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false

metaM udpacgal c
is: CHEBI:57847
boundary condition: false
type: Species
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203

metaR MAGt
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
name: monoacylglycerol 2 transport
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
reversible: true
kinetic law: MODEL1310110049#

metaR TRPt4
reversible: false
reactant: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000304
kinetic law: MODEL1310110049#
name: L-tryptophan transport in via sodium symport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110049#_27cb3554_66c0_42f0_ab5e_4d26e076ccc4
constant: false
boundary condition: true
is encoded by: hsa:4698
name: NDUFA5
initial concentration: NaN
type: Species
initial amount: NaN
is: Q16718
has only substance units: false
is: SBO:0000252

metaR SPC HSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is: SBO:0000185
fast: false
name: sphingosylphosphorylcholine transport (diffusion)
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_43856f96_3d29_4a13_8b67_196b90ecfb4c
initial concentration: NaN
is encoded by: hsa:1629
has only substance units: false
is: SBO:0000252
is: P11182
constant: false
initial amount: NaN
name: DBT
boundary condition: true
type: Species

metaR MAL Lte
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Transport of L-malate
is described by: ECO:0000134
product: MODEL1310110049#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM c4crn e
name: butyryl carnitine
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
type: Species
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
initial amount: NaN
is: HMDB02013
is: SBO:0000247
is: C02862

metaM h x
is: SBO:0000247
has only substance units: false
is: CHEBI:24636
type: Species
constant: false
is: C00080
initial amount: NaN
name: proton
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

http://identifiers.org/biomodels.db/MODEL1310110049#_bc8be80b_d644_47ab_a348_a0b8e02e9ec9
is encoded by: hsa:6799
name: SULT1A2
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaM dhcholestanate c
has only substance units: false
initial concentration: 1.0
is: HMDB00359
initial amount: NaN
is: CHEBI:16577
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_043f2b80_896d_4c94_8628_7eb0a8b477c3
constant: false
boundary condition: true
is: E7EPT3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:501
is: SBO:0000252
type: Species
name: ALDH7A1
initial amount: NaN

metaR DMATTx
type: Reaction
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reversible: false
reactant: MODEL1310110049#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.1
name: dimethylallyltranstransferase
modifier: MODEL1310110049#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_2ff7e3f0_5522_4e87_85f6_d0f5649ca1ad
is encoded by: hsa:29922
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: Q9Y5B8
name: NME7

metaM spmd e
initial concentration: 1.0
initial amount: NaN
is: C00315
is: CHEBI:57834
is: HMDB01257
name: Spermidine
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315

metaR TCYNTtm
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
fast: false
is described by: ECO:0000000
product: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
name: Thiocyanate transport via diffusion (mitochondrial)

http://identifiers.org/biomodels.db/MODEL1310110049#_68ec1984_984e_4f75_a187_188f82a29068
type: Species
boundary condition: true
name: _AA278423_1_m
initial concentration: NaN
is encoded by: hsa:AA278423
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_8ec106dd_5615_4777_8a18_e178f5faea5c
is: P04066
is encoded by: hsa:2517
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: FUCA1
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_bf72212d_09fd_4e8a_8fab_e8ecdbde2fc7
is encoded by: hsa:3636
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O15357
name: INPPL1

metaM 3mox4hpac m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: CHEBI:28111
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
has only substance units: false
is: HMDB05175
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_369a926f_1aca_4ba6_a5a6_d1f058a1709e
name: BCAT1
boundary condition: true
is encoded by: hsa:586
constant: false
is: P54687
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_9d74600f_6f19_4790_a3ab_2064e1f42aae
is: P23677
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: ITPKA
is encoded by: hsa:3706
initial amount: NaN
is: SBO:0000252
type: Species

metaM CE4872 m
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: HMDB00127
is: CHEBI:15748
type: Species

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR FUT99g
name: Alpha-(1,3)-fucosyltransferase
reversible: false
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.152
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110049#_8147a1d9_c59b_4b14_bccb_14ae0d2e6805
boundary condition: true
name: NT5E
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: P21589
is encoded by: hsa:4907
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5af31fc0_0253_4ee1_99b1_b4528c51a7f7
initial amount: NaN
name: GALNT4
is encoded by: hsa:8693
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q8N4A0
constant: false
has only substance units: false

metaR O2tp
name: O2 transport, peroxisomal
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_18e03c44_819f_422a_9a9d_cf33ad7c8168
type: Species
boundary condition: true
is: Q53HE2
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:7167
name: TPI1
has only substance units: false
initial concentration: NaN

metaR LNLNCAt
reversible: true
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaR CSNAT2x
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.137
is: SBO:0000176

metaM r5p r
type: Species
has only substance units: false
constant: false
is: HMDB00618
boundary condition: false
initial concentration: 1.0
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117

http://identifiers.org/biomodels.db/MODEL1310110049#_8ac5e8f0_dcab_46ef_9fa2_9d1e7745057b
is: SBO:0000252
type: Species
constant: false
is: A8K092
is encoded by: hsa:498
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ATP5A1
has only substance units: false

metaR DHORD9
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
reversible: false
is version of: http://identifiers.org/ec-code/1.3.5.2
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: dihydoorotic acid dehydrogenase (quinone10)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_3fbb4fda_2ad7_408b_9233_622d12f97c8d
boundary condition: true
name: ENTPD3
initial concentration: NaN
is encoded by: hsa:956
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is: O75355
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_ba304bd3_08fd_4fd1_bc0b_d74b0d9a4588
type: Species
is: SBO:0000252
name: DCXR
is encoded by: hsa:51181
initial concentration: NaN
is: Q7Z4W1
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaM m4mpdol L r
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:37633
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR r0812
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110049#

metaR SO4t4 2
reactant: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
name: sulfate transport via sodium symport
product: MODEL1310110049#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
fast: false
kinetic law: MODEL1310110049#

metaM 42A3HP24DB c
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
type: Species
is: HMDB04083
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: http://identifiers.org/pubchem.compound/7956
initial concentration: 1.0
is: C05645

http://identifiers.org/biomodels.db/MODEL1310110049#_36abb9e3_b0e6_4ba7_874d_81f47bee9a43
has only substance units: false
is encoded by: hsa:4715
initial concentration: NaN
name: NDUFB9
initial amount: NaN
boundary condition: true
is: Q9Y6M9
constant: false
is: SBO:0000252
type: Species

metaR S23T4g
product: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_df5f930b_7946_4414_af55_61eac9dae651
is: Q9UNP4
has only substance units: false
constant: false
type: Species
name: ST3GAL5
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8869
boundary condition: true

metaR O2tn
fast: false
product: MODEL1310110049#
name: O2 nuclear transport
reversible: true
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_038ee5ba_7f64_49d3_8bb4_91bca98c0992
boundary condition: true
name: RPN2
is: P04844
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:6185

http://identifiers.org/biomodels.db/MODEL1310110049#_d30bd5ab_2273_4160_b3b7_3ca98ab28ef1
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: HSD3B2
type: Species
is: P26439
constant: false
is: SBO:0000252
is encoded by: hsa:3284

metaR PTPAT
is version of: http://identifiers.org/ec-code/2.7.7.3
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000269
is: SBO:0000176
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)

metaM 5adtststerone c
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: SBO:0000247
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
is: CHEBI:16330
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaR P4508B11r
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
name: sterol 12-alpha-hydroxylase
fast: false
reversible: false
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.14.13.95
is described by: ECO:0000269
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_f98676ac_91d8_41d7_b6f6_76202846aa16
type: Species
is: B7Z6S1
constant: false
boundary condition: true
name: GBA
has only substance units: false
is encoded by: hsa:2629
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
constant: false
is: CHEBI:26174
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
name: i-antigen
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0

metaR HEX10
modifier: MODEL1310110049#
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
name: hexokinase (D-glucosamine:ATP)
type: Reaction
product: MODEL1310110049#
reversible: false
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: MODEL1310110049#

metaR GLCtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
name: glucose efflux from lysosome
reversible: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000

metaR O2tm
type: Reaction
name: O2 transport (diffusion)
is: SBO:0000185
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF

metaR NDPK1n
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
reactant: MODEL1310110049#
is described by: ECO:0000134
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176

metaR GALASE12ly
product: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
modifier: MODEL1310110049#
name: beta-galactosidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR SPHS1Ptr
is: SBO:0000185
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
name: sphingosine-1-phosphate transport

http://identifiers.org/biomodels.db/MODEL1310110049#_9da23cb6_e776_4147_b070_15b248a0206c
has only substance units: false
is: Q9P212
initial concentration: NaN
boundary condition: true
name: PLCE1
type: Species
is: SBO:0000252
is encoded by: hsa:51196
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_c8cfd722_63e0_4414_a305_434baa320b1e
is: O75452
boundary condition: true
is encoded by: hsa:8608
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: RDH16
initial concentration: NaN

metaR NAGA2ly
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
type: Reaction
product: MODEL1310110049#
is: SBO:0000176
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.49
name: N-acetylgalactosaminidase, alpha-
modifier: MODEL1310110049#

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_eba9e58d_bf24_403f_9d5b_aa19e3d5dcbf
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:2194
boundary condition: true
name: FASN
constant: false
is: P49327
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_c41b9acb_dcfe_4ffe_a008_1e42f5771eed
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: B4DY56
type: Species
is encoded by: hsa:498
name: ATP5A1

metaR NDPK1m
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110049#_7b6ee789_a73d_4ced_866c_ac70c0c495ec
is: SBO:0000252
is: Q99643
initial concentration: NaN
is encoded by: hsa:6391
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: SDHC

http://identifiers.org/biomodels.db/MODEL1310110049#_791b1e10_b7b3_4d40_b350_2ea19fa7c345
has only substance units: false
constant: false
is encoded by: hsa:4645
initial concentration: NaN
is: Q9H6Y6
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: MYO5B

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_607aa2f4_bb5a_45e6_bdf5_71383a8b6305
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:341947
name: COX8C
is: Q7Z4L0
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
name: blood group intracellular transport
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reversible: true
fast: false

metaM ivcoa m
name: Isovaleryl-CoA
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01113
type: Species
boundary condition: false
is: CHEBI:57345
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939

metaM acgpail hs c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57265
boundary condition: false
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM 5adtststerone e
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
has only substance units: false
type: Species
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
constant: false
initial concentration: 1.0
is: HMDB02961
boundary condition: false

metaR Ser Thrtg
kinetic law: MODEL1310110049#
is: SBO:0000185
name: Ser/Thr transport (from golgi to lysosome)
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:

metaR G14T6g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110049#

metaR SERDGLNexR
is described by: ECO:0000304
name: D-Serine/Glutamine reversible exchange
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_e1cb06a9_23ad_4685_8884_d99e8ed48f70
boundary condition: true
is encoded by: hsa:2877
name: GPX2
is: P18283
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaR r2521
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
reversible: true
type: Reaction
name: Utilized transport
reactant: MODEL1310110049#

metaR HISTAtu
name: Histamine uniport
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110049#

metaM HC01231 c
initial concentration: 1.0
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
type: Species
constant: false
is: SBO:0000247
has only substance units: false

metaR ATPS4m
name: ATP synthase (four protons for one ATP)
product: MODEL1310110049#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.6.4.6
is version of: http://identifiers.org/ec-code/3.6.1.14
reactant: MODEL1310110049#
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
is version of: http://identifiers.org/ec-code/3.6.3.14
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_fc07046a_b420_4948_918a_715359ee5ffa
initial amount: NaN
name: SKIV2L2
is: Q3MHC9
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:23517
constant: false
boundary condition: true
has only substance units: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM akg x
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16810
initial amount: NaN
type: Species
is: HMDB00208
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-oxoglutarate(2-)

metaR r1626
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM ksii core2 pre2 g
is: C00130
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 2
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: HMDB00175
is: CHEBI:58053
constant: false
has only substance units: false
initial concentration: 1.0

metaR G14T2g
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_a6128b68_bb71_4113_8f6a_96e4e7d28d50
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: Q8N1Q1
name: CA13
type: Species
is encoded by: hsa:377677

metaM HC01434 x
boundary condition: false
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: oxalatosuccinate(3-)
initial amount: NaN

metaR CYOOm3
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is: SBO:0000185
is described by: ECO:0000134
name: cytochrome c oxidase, mitochondrial Complex IV
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.9.3.1
fast: false
kinetic law: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#

metaR TRPt
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
reversible: true
modifier: MODEL1310110049#
name: L-tryptophan transport
is described by: ECO:0000269
product: MODEL1310110049#
fast: false

metaM ddsmsterol r
is: CHEBI:27910
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 7-dehydrodesmosterol
boundary condition: false
is: HMDB03896
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
constant: false

metaR r2520
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reversible: true
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaR r0365
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
is described by: ECO:0000000
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reversible: false
modifier: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_4218e0c7_a212_48c4_a513_b6c74d7f8d12
constant: false
boundary condition: true
has only substance units: false
name: ACADVL
is: P49748
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:37

http://identifiers.org/biomodels.db/MODEL1310110049#_cd8ae3a6_1829_4a5f_b6dd_5bbc43a45d02
boundary condition: true
is encoded by: hsa:81579
is: Q542Y6
name: PLA2G12A
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM pmtcrn m
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00222
initial concentration: 1.0
name: L-palmitoylcarnitine
initial amount: NaN
has only substance units: false
is: CHEBI:17490
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_9ff4193a_c925_4fb5_8bc2_f7540678f7f8
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:4712
name: NDUFB6
initial amount: NaN
is: Q5VYT2
is: SBO:0000252
type: Species
has only substance units: false

metaR r1625
is: SBO:0000185
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110049#

metaR GHMT2r
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
name: glycine hydroxymethyltransferase, reversible
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000269
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.1

metaR PPItm
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
is described by: ECO:0000134
reversible: true
is: SBO:0000185
reactant: MODEL1310110049#

metaM fad r
is: HMDB01248
type: Species
has only substance units: false
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238

metaR RE0915E
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0915
reversible: true
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110049#
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_ae3072d7_7849_4d0f_a2ca_9508cf7eebea
name: ALDOC
has only substance units: false
is: SBO:0000252
is: P09972
is encoded by: hsa:230
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species

metaM acrn x
is: HMDB00201
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57589
initial concentration: 1.0
boundary condition: false
name: O-acetylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110049#_b51e32c0_0754_44f8_979c_67279b38d69a
name: PGM1
type: Species
boundary condition: true
constant: false
is: B4DPV0
is: SBO:0000252
is encoded by: hsa:5236
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM n2m2nmn l
is: HMDB00939
initial concentration: 1.0
is: CHEBI:16680
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C50H84N4O36 CHARGE: 0
boundary condition: false

metaR r1624
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
reversible: true

metaR 3MOX4HOXPGALDOX NADP
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110049#

metaM retinol cis 13 c
constant: false
name: 13-cis-retinol
has only substance units: false
is: SBO:0000247
is: HMDB06217
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13-
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:45479
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_a0252c9a_58e2_44cb_9043_c9fd9acdf454
is: Q9Y673
type: Species
boundary condition: true
is encoded by: hsa:29880
is: SBO:0000252
name: ALG5
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

metaR CHOLtn
reversible: true
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110049#
fast: false
name: Choline transport, nuclear through pores
reactant: MODEL1310110049#

metaR MI14P4P
name: inositol-1,4-bisphosphate 4-phosphatase
reversible: false
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_4cf40244_7396_4bd8_b5e2_8bfa632d7dd2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3033
type: Species
constant: false
is: SBO:0000252
name: HADH
is: Q16836
boundary condition: true
has only substance units: false

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR r1623
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110049#
type: Reaction

metaM 5dhf e
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: pentaglutamyl folate (DHF)
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: HMDB06487

http://identifiers.org/biomodels.db/MODEL1310110049#_b253c375_2442_4c42_b7fc_c18fd85556f1
type: Species
has only substance units: false
initial amount: NaN
is: Q9Y259
boundary condition: true
name: CHKB
is encoded by: hsa:1120
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_75cb4fef_909f_4c3b_a1a8_9fe364fec11b
is: Q8NCG5
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10164
name: CHST4
initial amount: NaN
type: Species

metaM ksi deg20 l
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:12936
has only substance units: false
name: keratan sulfate I, degradation product 20
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
type: Species
is: HMDB00143

metaR DNDPt9m
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
product: MODEL1310110049#
name: dADP transport via dTDP antiport
type: Reaction
reversible: false

metaM 4pyrdx e
boundary condition: false
type: Species
constant: false
name: 4-pyridoxate
initial amount: NaN
is: HMDB00017
initial concentration: 1.0
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: CHEBI:30959
has only substance units: false
is: SBO:0000247

metaR RE1520M
name: RE1520
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#

metaM ptdcacoa m
type: Species
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB06499
initial concentration: 1.0
constant: false
name: pentadecanoyl Coenzyme A

metaR PIACGT
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.83
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
reversible: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.198
name: phosphatidylinositol N-acetylglucosaminyltransferase
reactant: MODEL1310110049#

metaM pydx c
is: HMDB01545
initial amount: NaN
type: Species
is: CHEBI:17310
constant: false
initial concentration: 1.0
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
name: Pyridoxal
is: C00250
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM h2o2 m
has only substance units: false
is: CHEBI:16240
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
boundary condition: false
is: C00027
name: Hydrogen peroxide
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_3c36b381_6eb8_40fb_a825_2020df372bd5
initial amount: NaN
boundary condition: true
is: Q9UJ70
name: NAGK
has only substance units: false
is encoded by: hsa:55577
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
boundary condition: false
is: SBO:0000247
is: CHEBI:28325
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_87d8248a_78f4_48d0_9ee6_5af3e0a9c813
name: PLA2G2E
has only substance units: false
is: Q9NZK7
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:30814
type: Species
initial amount: NaN
initial concentration: NaN

metaM pmtcrn r
is: SBO:0000247
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17490
is: HMDB00222

metaR r0360
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/6.2.1.16
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_529235ff_6b97_47f0_9c3c_b030825812f1
initial concentration: NaN
is: O15244
boundary condition: true
constant: false
name: SLC22A2
is encoded by: hsa:6582
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_4d83007f_087a_49f6_a84c_dbb2f2f70e61
initial concentration: NaN
is: SBO:0000252
is: Q5JPH6
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:124454
name: EARS2

metaM CE0713 m
initial concentration: 1.0
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
has only substance units: false
name: 3-oxolinoleoyl-CoA
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB02329
is: CHEBI:30623

http://identifiers.org/biomodels.db/MODEL1310110049#_4cb06575_6368_454e_892a_b8f00a94c83c
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: SLCO2A1
initial amount: NaN
is: Q92959
is: SBO:0000252
constant: false
is encoded by: hsa:6578

http://identifiers.org/biomodels.db/MODEL1310110049#_00da76e7_0222_44e7_866c_1bbc60aa39bb
initial amount: NaN
has only substance units: false
boundary condition: true
name: ADH6
is: P28332
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:130
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_200b66ca_4ce2_480c_a47a_51278ec5d1eb
is encoded by: hsa:953
type: Species
initial amount: NaN
is: Q86VV3
initial concentration: NaN
is: SBO:0000252
name: ENTPD1
has only substance units: false
boundary condition: true
constant: false

metaR ADNt
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000269
name: adenosine facilated transport in cytosol
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
type: Reaction
is: SBO:0000185

metaR AG13T17g
modifier: MODEL1310110049#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110049#
type: Reaction
reversible: false
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110049#_78963ffe_3f5b_4568_b72a_0cc6df7e2adb
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4723
constant: false
name: NDUFV1
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: E5KNH5

metaR OCDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110049#
name: fatty acid transport via diffusion
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_a771021f_1ca7_4fc0_85ff_3306b44d56cb
name: _AA419122_1_c
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AA419122
is: SBO:0000252
boundary condition: true

metaR SPMDOX
type: Reaction
name: Spermidine:(acceptor) oxidoreductase
reactant: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.99.6 Confidence Level: 2 AUTHORS: PMID:10657958 NOTES:SAB
fast: false
kinetic law: MODEL1310110049#
reversible: false

metaR PTDCACRNCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000176
modifier: MODEL1310110049#
name: pentadecanoate transport into the mitochondria
product: MODEL1310110049#

metaR DURAD
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction
modifier: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000269
name: dihydrouracil dehydrogenase (NADP)
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_359ab8a3_a9e8_4699_9f5c_5f1d2eabd6b0
has only substance units: false
name: PIGM
is encoded by: hsa:93183
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: Q9H3S5
is: SBO:0000252

metaR r1629
fast: false
reversible: true
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_de9b9429_cf1d_4730_bbdb_053e51c10c2a
type: Species
is encoded by: hsa:BC005314
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: _BC005314_1_x
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_b316116d_5fe4_4e80_b370_5a29cd36edf5
initial amount: NaN
initial concentration: NaN
name: SLC2A12
is encoded by: hsa:154091
is: SBO:0000252
has only substance units: false
is: Q8TD20
boundary condition: true
constant: false
type: Species

metaR ACCOAC
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_d4b01389_9f95_425e_a600_4397f2df30a0
is: SBO:0000252
has only substance units: false
boundary condition: true
name: KL
is: Q9UEF7
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:9365
initial concentration: NaN

metaR SERGLYexR
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
name: L-Serine/Glycine reversible exchange
reactant: MODEL1310110049#

metaM CE5118 m
type: Species
initial concentration: 1.0
is: HMDB00127
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:15748
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
boundary condition: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110049#_997449e4_0b05_4f34_9e9e_135cd2b91b66
is: SBO:0000297
type: Species
name: ADH1B:ADH1C
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:126
constant: false
has only substance units: false
has part: P00326

metaR PTDCACRNCPT1
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110049#
name: carnitine fatty-acyl transferase
is described by: ECO:0000269

metaM acald c
constant: false
is: HMDB00990
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
type: Species
boundary condition: false
name: acetaldehyde
is: CHEBI:15343
is: SBO:0000247

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM oaa x
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00036
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16452
name: Oxaloacetate
is: SBO:0000247
is: HMDB00223

http://identifiers.org/biomodels.db/MODEL1310110049#_d30472e3_5ec5_4dd2_aab4_833856cfed07
is: Q9Y6M9
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:4715
constant: false
name: NDUFB9
type: Species
initial concentration: NaN

metaM fad x
name: Flavin adenine dinucleotide oxidized
has only substance units: false
type: Species
is: HMDB01248
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
initial concentration: 1.0
is: CHEBI:16238
initial amount: NaN
is: SBO:0000247

metaR PNTK
reactant: MODEL1310110049#
name: pantothenate kinase
type: Reaction
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110049#
reversible: false

metaR DHCR243r
is: SBO:0000176
modifier: MODEL1310110049#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: 24-dehydrocholesterol reductase [Precursor]
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
reversible: false

metaM h2o2 n
type: Species
constant: false
initial amount: NaN
is: HMDB03125
is: SBO:0000247
boundary condition: false
is: CHEBI:16240
name: hydrogen peroxide
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaM acrn r
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB00201
name: O-acetylcarnitine
is: CHEBI:57589

http://identifiers.org/biomodels.db/MODEL1310110049#_e297a49e_8732_4d9d_8148_7604136ad6f9
is encoded by: hsa:55753
has only substance units: false
initial amount: NaN
is: Q9ULD0
boundary condition: true
initial concentration: NaN
name: OGDHL
is: SBO:0000252
type: Species
constant: false

metaR r1627
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
product: MODEL1310110049#
is: SBO:0000185

metaM CE5120 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: HMDB00127
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:15748
has only substance units: false
name: trans-2-cis-8-tetradecadienoyl-CoA
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_7321b97c_2feb_4d29_8b90_8a392bc84014
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:204
has only substance units: false
boundary condition: true
name: AK2
constant: false
is: P54819

metaM acald e
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:15343
is: HMDB00990

metaR PRASCS
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110049#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is: SBO:0000176
product: MODEL1310110049#
fast: false

metaM Ser Thr l
is: SBO:0000247
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:58190
is: HMDB00224
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_5cdaeb0e_4204_4eb2_b1c8_98fc60ac9e14
is: O60503
boundary condition: true
name: ADCY9
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:115

http://identifiers.org/biomodels.db/MODEL1310110049#_a74963bb_517e_4fc1_98ff_c06ba2aaf7b0
type: Species
is encoded by: hsa:5336
name: PLCG2
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P16885
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_e92cbb91_202d_43c5_a8e7_03bd632a6f56
initial concentration: NaN
has only substance units: false
type: Species
is: Q9P2T1
is: SBO:0000252
is encoded by: hsa:51292
initial amount: NaN
name: GMPR2
boundary condition: true
constant: false

metaR Coqe
type: Reaction
name: Transport of q10
fast: false
reactant: MODEL1310110049#
reversible: true
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110049#

metaM m8masn r
type: Species
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
has only substance units: false
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

metaR ARACHCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
name: carnitine transferase
modifier: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_b04f1bd1_78e2_4886_af7a_32faaf50fc1e
is: SBO:0000252
boundary condition: true
is: P34896
constant: false
initial concentration: NaN
initial amount: NaN
name: SHMT1
type: Species
is encoded by: hsa:6470
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_55dc2d32_041a_489d_b185_9d55181d12d4
name: B3GNT2
is: SBO:0000252
is encoded by: hsa:10678
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR GUAt
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
name: Guanine transport
kinetic law: MODEL1310110049#
is described by: ECO:0000269
type: Reaction

metaR r1593
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110049#_bced860f_5aa3_46e3_a235_c9e15ca2ab0e
boundary condition: true
initial concentration: NaN
name: NOS3
has only substance units: false
is encoded by: hsa:4846
initial amount: NaN
is: A0S0A7
is: SBO:0000252
constant: false
type: Species

metaM ade c
name: Adenine
is: HMDB00034
boundary condition: false
initial concentration: 1.0
is: C00147
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: CHEBI:16708
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_c4e905f5_03f8_42c3_bd05_fa3c8e412dcc
has only substance units: false
boundary condition: true
constant: false
name: _NOS2A_1_e
is: SBO:0000252
type: Species
is encoded by: hsa:NOS2A
initial amount: NaN
initial concentration: NaN

metaM Rtotal3coa c
name: R total 3 Coenzyme A
boundary condition: false
is: HMDB01448
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16189
initial amount: NaN
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4

metaM galgalgalthcrm hs c
boundary condition: false
type: Species
is: CHEBI:12936
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
initial amount: NaN
is: HMDB00143
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_0980cf47_78f0_4e51_a826_01a56da3847a
is: Q5FWE9
name: ACOT12
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:134526
is: SBO:0000252

metaR NACHEXA10ly
is: SBO:0000176
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaM pe hs r
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:16038
is: SBO:0000247
type: Species
name: phosphatidylethanolamine
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR NTD2m
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
is described by: ECO:0000269
name: 5'-nucleotidase (UMP), mitochondrial
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_68709923_dc0e_4856_8cb9_a3cfb43575f6
is: B4DUG1
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:9187
name: SLC24A1
is: SBO:0000252

metaR GLUPRT
is: SBO:0000176
reversible: false
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.14
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
name: glutamine phosphoribosyldiphosphate amidotransferase
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_0de3e4fb_8220_4d44_a036_204a75b7e858
is encoded by: hsa:4513
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q7GXZ8
name: COX2
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r1592
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#

metaM akg m
is: HMDB00208
is: CHEBI:16810
is: SBO:0000247
is: C00026
name: 2-Oxoglutarate
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
boundary condition: false
initial amount: NaN

metaM HC01231 m
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
type: Species
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false
is: CHEBI:58480
is: SBO:0000247

metaR RE0926E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110049#
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
fast: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#

metaR S6T3g
is described by: ECO:0000000
product: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.17
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.8.2.21

http://identifiers.org/biomodels.db/MODEL1310110049#_e2ce9168_a8e7_493f_868e_26803a26bce9
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: DHFR
is: P00374
type: Species
boundary condition: true
is encoded by: hsa:1719
constant: false

metaR C4tmc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_5ab2109c_9e32_4385_9809_d164b2160680
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: OXSM
boundary condition: true
is encoded by: hsa:54995
has only substance units: false
type: Species
is: Q9NWU1

metaR r1591
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_87621e61_e91d_45a4_a2c3_e4237eec13c8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:93034
type: Species
initial amount: NaN
is: B3KUK6
name: NT5C1B
constant: false
is: SBO:0000252
has only substance units: false

metaM galgalgalthcrm hs e
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
has only substance units: false
constant: false
is: CHEBI:0
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00143
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
is: SBO:0000247
is: C00124

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM dutp c
name: dUTP
is: C00460
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01191
is: CHEBI:17625
has only substance units: false
type: Species

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM ade e
name: adenine
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species
initial concentration: 1.0
is: HMDB00034
is: SBO:0000247
is: CHEBI:16708
boundary condition: false
constant: false

metaR ACOAD8m
fast: false
reactant: MODEL1310110049#
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
reversible: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.10
is: SBO:0000176
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_8a4e77e4_4e43_4d45_8462_6ef7957e295b
is encoded by: hsa:4710
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NDUFB4
type: Species
constant: false
is: O95168
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_bed45bba_26f3_4393_bad4_fc2445c69a91
type: Species
has only substance units: false
initial concentration: NaN
name: CEPT1
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:10390
is: B3KN25

metaR GK1
kinetic law: MODEL1310110049#
name: guanylate kinase (GMP:ATP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
fast: false
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR r2526
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110049#
reversible: true

metaR r1590
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185

metaM 2dr1p c
is: CHEBI:58576
constant: false
type: Species
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: C00672
is: SBO:0000247
is: HMDB01351
initial concentration: 1.0
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_032c07ff_43f5_428c_a3db_d71f056d240b
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:1340
initial amount: NaN
name: COX6B1
constant: false
has only substance units: false
boundary condition: true
is: P14854

metaR FAOXC16OHC16r
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM h2o2 e
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:16240
initial amount: NaN
name: hydrogen peroxide
boundary condition: false
is: HMDB03125

metaR FADH2tx
product: MODEL1310110049#
reactant: MODEL1310110049#
name: FADH2 transporter, peroxisomal
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_a53807a8_0b0a_40a9_9d58_03a4d6964a02
is: O14561
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4706
constant: false
boundary condition: true
name: NDUFAB1

http://identifiers.org/biomodels.db/MODEL1310110049#_3cdbe2a5_c993_41c5_a9d7_1b94b6fda4a0
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AA081045
name: _AA081045_1_e
is: SBO:0000252

metaM succ m
is: CHEBI:30031
is: HMDB00254
boundary condition: false
is: C00042
initial concentration: 1.0
is: SBO:0000247
name: Succinate
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false

metaR r1007
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000
name: Facilitated diffusion
is: SBO:0000185
reversible: true
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR r2525
is described by: ECO:0000000
product: MODEL1310110049#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_72496d5e_77cf_4b4c_b2a2_3f384f1def13
initial concentration: NaN
is: SBO:0000252
type: Species
name: _T83654_1_c
initial amount: NaN
is encoded by: hsa:T83654
has only substance units: false
constant: false
boundary condition: true

metaR RE1807C
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
reactant: MODEL1310110049#
name: RE1807
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
fast: false
is: SBO:0000176

metaM h2o2 c
is: CHEBI:16240
name: Hydrogen peroxide
initial concentration: 1.0
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB03125
constant: false
is: C00027

metaM pan4p m
is: CHEBI:47942
is: SBO:0000247
name: pantetheine 4'-phosphate(2-)
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01416

http://identifiers.org/biomodels.db/MODEL1310110049#_2d162a8d_bb84_4e64_9256_4edba1b37a69
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ALAS1
is encoded by: hsa:211
is: P13196

metaR r1008
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000000

metaM 5mdru1p c
constant: false
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
is: HMDB01299
type: Species
initial amount: NaN
is: CHEBI:58548
notes: FORMULA: C6H11O7PS CHARGE: -2
has only substance units: false
boundary condition: false
is: C04582
is: SBO:0000247
initial concentration: 1.0

metaR RE0512M
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110049#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE0512
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false

metaM c226coa x
initial amount: NaN
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247

metaR r0655
reversible: true
product: MODEL1310110049#
reactant: MODEL1310110049#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#

metaR NACHEXA16ly
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110049#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_4d22811a_7a0b_4529_a628_d3c066d66517
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5052
name: PRDX1
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaM naglc2p L c
is: CHEBI:18278
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog

http://identifiers.org/biomodels.db/MODEL1310110049#_e6493e93_e397_4f3f_81e7_125134776653
initial concentration: NaN
is: SBO:0000252
name: HSD3B1
is: P14060
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:3283
constant: false

metaM pmtcrn x
initial amount: NaN
is: HMDB00222
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false
constant: false
is: CHEBI:17490
type: Species
name: L-palmitoylcarnitine
is: SBO:0000247

metaM Ser Thr g
notes: FORMULA: XH CHARGE: 0
is: CHEBI:58336
initial concentration: 1.0
is: HMDB00645
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_97836328_ebf2_45eb_b7c3_88931e8bfecc
initial amount: NaN
is encoded by: hsa:8525
type: Species
name: DGKZ
boundary condition: true
is: B7Z6M3
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r0656
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
type: Reaction
reversible: false
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
fast: false

metaM 2mop c
has only substance units: false
type: Species
is: HMDB01172
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
constant: false
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_623d4919_2661_4e2f_a318_03b6456d43ca
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4514
initial concentration: NaN
is: P00414
type: Species
initial amount: NaN
name: COX3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_94364ea8_3a31_4344_89ff_3c8df637778f
name: LDHAL6A
is: Q6ZMR3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:160287
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_3d276b77_acbe_452c_8472_aa13aa923f75
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI915649
constant: false
type: Species
initial amount: NaN
name: _AI915649_1_c

http://identifiers.org/biomodels.db/MODEL1310110049#_24d83103_aff3_44c4_9f14_d74cd5420c58
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:7498
name: XDH
is: P47989
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_35d964b9_b778_4c3c_a3b0_a5e5b77a37e3
initial concentration: NaN
type: Species
is: Q99519
is encoded by: hsa:4758
boundary condition: true
name: NEU1
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaR ARACHCPT1
reactant: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction

metaM dutp n
initial amount: NaN
is: HMDB01191
type: Species
initial concentration: 1.0
is: CHEBI:17625
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460

metaM 3ohdcoa x
constant: false
initial concentration: 1.0
is: CHEBI:57349
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
name: 3-oxopalmitoyl-CoA(4-)
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB06402

metaR GHMT2rm
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
kinetic law: MODEL1310110049#
product: MODEL1310110049#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.1
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#
name: glycine hydroxymethyltransferase, reversible, mitochondrial

metaR ALCD2yf
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
reversible: false
fast: false
is described by: ECO:0000134
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.2

metaR 3HCO3 NAt
fast: false
reactant: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
product: MODEL1310110049#
name: 3HCO3_NAt
type: Reaction

metaM gmp g
is: HMDB01397
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN
has only substance units: false
is: CHEBI:58115
name: GMP(3-)
constant: false
type: Species
is: SBO:0000247

metaM srtn c
type: Species
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
is: CHEBI:350546
has only substance units: false
initial amount: NaN
is: HMDB00259
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR LPASE
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: lysophospholipase
is version of: http://identifiers.org/ec-code/3.1.1.5
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
reactant: MODEL1310110049#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110049#

metaR r0666
modifier: MODEL1310110049#
product: MODEL1310110049#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110049#
is described by: ECO:0000000

metaM dutp m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17625
boundary condition: false
initial amount: NaN
is: HMDB01191
type: Species
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_706081ec_b216_4e4e_912b_ca740e928659
name: ST3GAL2
type: Species
is: SBO:0000252
is: Q16842
boundary condition: true
is encoded by: hsa:6483
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaM dhf e
initial amount: NaN
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
type: Species
is: CHEBI:57451
is: SBO:0000247
name: dihydrofolate(2-)
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR DM 13 cis retn n
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-retinoate demand
type: Reaction

metaM gbside hs e
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
name: globoside
has only substance units: false
is: CHEBI:18259

metaR 4HGLSDm
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000212

metaM fe3 c
boundary condition: false
is: SBO:0000247
is: HMDB12943
constant: false
name: Fe3+
type: Species
notes: FORMULA: Fe CHARGE: 3
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_dc59179b_9290_4469_baa2_698319dc18d8
is: SBO:0000252
name: GNE
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: B7Z428
is encoded by: hsa:10020

http://identifiers.org/biomodels.db/MODEL1310110049#_951d2765_f55a_4a66_a3f5_8102698c3c55
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:728441
boundary condition: true
name: GGT2
initial concentration: NaN
initial amount: NaN

metaM HC00900 c
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: SBO:0000247
is: CHEBI:30860
name: Methylmalonate
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_bb4f7b25_214d_4feb_a803_c731864d5c9d
initial concentration: NaN
constant: false
name: INPP4A
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3631
type: Species

metaR r1598
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
constant: false
is: HMDB01206
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: Type IIIA glycolipid
boundary condition: false
is: CHEBI:57288

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_97f37321_305e_4d11_9d0c_143fae70fc5f
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:D87002
is: SBO:0000252
name: _D87002_1_e
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_11719163_3a36_4a87_8192_77532f3b76a9
is: Q9NRF8
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: CTPS2
is encoded by: hsa:56474

metaM fad c
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
is: HMDB01248
is: CHEBI:16238
initial amount: NaN
type: Species
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR HMGCOASi
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110049#

metaR r2308
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110049#_35cd6ee7_6085_4ed5_9565_287020f8ea3e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:55811
has only substance units: false
is: F5GWS5
name: ADCY10

metaR r1599
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#

metaM mmcoa S m
name: (S)-methylmalonyl-CoA(5-)
type: Species
has only substance units: false
is: HMDB02310
is: CHEBI:57327
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM gbside hs c
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
name: globoside
has only substance units: false
is: CHEBI:18259
boundary condition: false

metaM pe hs m
initial concentration: 1.0
type: Species
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16038
constant: false
boundary condition: false

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR r0097
reversible: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
is: SBO:0000176
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
fast: false

metaM fe3 e
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial concentration: 1.0
is: HMDB12943
boundary condition: false
constant: false
name: Fe3+
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:29034

http://identifiers.org/biomodels.db/MODEL1310110049#_c70cfc7a_146d_4ccb_91b0_c9ab2ff906da
is encoded by: hsa:30061
initial concentration: NaN
type: Species
has only substance units: false
is: Q9NP59
name: SLC40A1
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaM fad e
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial amount: NaN
is: C00016
initial concentration: 1.0
boundary condition: false
is: HMDB01248
has only substance units: false
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238

metaM oaa m
type: Species
is: HMDB00223
is: CHEBI:16452
name: Oxaloacetate
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: C00036
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

metaM asp D x
boundary condition: false
has only substance units: false
type: Species
is: HMDB06483
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
is: CHEBI:29990
initial concentration: 1.0
name: D-aspartate(1-)
initial amount: NaN
constant: false

metaR r2309
kinetic law: MODEL1310110049#
is: SBO:0000185
reactant: MODEL1310110049#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true

metaM hgentis c
has only substance units: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
type: Species
initial concentration: 1.0
name: homogentisate
is: CHEBI:16169
initial amount: NaN
is: HMDB00130
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_1a64c9dd_8b25_46fc_9b42_b374d57f4bda
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: SLC7A6
is: Q92536
is encoded by: hsa:9057
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM akg e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
boundary condition: false
name: 2-oxoglutarate(2-)
constant: false
is: CHEBI:16810
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_9a53cc52_42d5_4b62_8f31_0f89778a4773
boundary condition: true
name: _AF080579_1_c
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AF080579
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d9a0de98_140c_406d_9036_2be9707f196c
type: Species
initial concentration: NaN
is: E9PB82
is encoded by: hsa:3295
name: HSD17B4
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaM tchola c
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:36257
is: HMDB00036
type: Species
initial amount: NaN
name: taurocholic acid
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
boundary condition: false

metaR RE2541E
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
name: RE2541
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
kinetic law: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01206
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: SBO:0000247
name: Type IIIA glycolipid
has only substance units: false
is: CHEBI:57288
constant: false

metaM pan4p e
is: C01134
has only substance units: false
name: Pantetheine 4'-phosphate
initial concentration: 1.0
is: CHEBI:47942
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR r1596
type: Reaction
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_2505b493_a5a2_4cd3_bba6_69a2b15ff3ad
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:1892
is: P30084
name: ECHS1
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_a95fa779_09f6_42f2_beea_83f3a37e38c4
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: ACAD8
has only substance units: false
is: Q6ZWP6
is encoded by: hsa:27034
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_cebac232_17d6_42f2_9c98_0eb69de5ee91
constant: false
type: Species
has only substance units: false
is: P33897
initial amount: NaN
name: ABCD1
initial concentration: NaN
is encoded by: hsa:215
boundary condition: true
is: SBO:0000252

metaR NACHEX27ly
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD

metaR CYTK13
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176

metaM galgalgalthcrm hs g
is: SBO:0000247
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
has only substance units: false
is: CHEBI:26174
boundary condition: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

metaR AKR1C42
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
reversible: false
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction

metaR 7DHCHSTEROLtr
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
reversible: true
kinetic law: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
name: cholesterol precursor intracellular transport
is: SBO:0000185

metaR r1597
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110049#

metaR r0661
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: false
product: MODEL1310110049#

metaM dhcholoylcoa x
is: SBO:0000247
constant: false
is: HMDB06895
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
boundary condition: false
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
has only substance units: false
is: CHEBI:27393
initial concentration: 1.0
type: Species

metaR CYTK14
name: cytidylate kinase (dCMP,UTP)
is: SBO:0000176
product: MODEL1310110049#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#

metaM akg c
is: HMDB00208
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:16810
name: 2-Oxoglutarate
is: C00026

metaR AG13T6g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000

metaM gmp c
is: CHEBI:58115
has only substance units: false
type: Species
is: C00144
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
initial amount: NaN
is: HMDB01397
is: SBO:0000247
name: GMP

http://identifiers.org/biomodels.db/MODEL1310110049#_3a0e83f7_b947_47aa_ad41_920f404672a6
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:1666
is: Q16698
has only substance units: false
name: DECR1
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_283e8452_b2c1_46e9_8e33_56e0a9a7788c
is: SBO:0000252
is encoded by: hsa:84720
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: PIGO
type: Species
is: Q8TEQ8
boundary condition: true

metaM srtn e
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00259
boundary condition: false
is: CHEBI:350546
name: serotonin(1+)
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

metaR FAOXC10C8x
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR r1594
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
reversible: true
reactant: MODEL1310110049#

metaM chsterol r
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
constant: false
type: Species
is: CHEBI:16113
is: HMDB00067
initial concentration: 1.0
name: cholesterol
has only substance units: false
is: SBO:0000247

metaR ACNAMPH
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
product: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
fast: false
kinetic law: MODEL1310110049#
reversible: false

metaM tchola e
constant: false
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0
is: HMDB00036
type: Species
initial amount: NaN
has only substance units: false
name: taurocholic acid
initial concentration: 1.0
boundary condition: false

metaR r2398
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false

metaM pan4p c
boundary condition: false
has only substance units: false
is: CHEBI:47942
type: Species
constant: false
is: C01134
is: SBO:0000247
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: HMDB01416
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
constant: false
initial amount: NaN
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Type IIIA glycolipid
type: Species
is: HMDB00304
is: SBO:0000247
is: CHEBI:57847

metaR r0660
is described by: ECO:0000000
fast: false
product: MODEL1310110049#
modifier: MODEL1310110049#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

metaR HMGLx
name: hydroxymethylglutaryl-CoA lyase
reactant: MODEL1310110049#
reversible: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.1.3.4
is: SBO:0000176
fast: false
modifier: MODEL1310110049#

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR GLNCYSNaEx
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110049#
reversible: false

metaM dhf c
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01056
initial amount: NaN
has only substance units: false
type: Species
name: 7,8-Dihydrofolate
is: C00415
initial concentration: 1.0
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaM acrn c
initial concentration: 1.0
boundary condition: false
is: HMDB00201
initial amount: NaN
name: O-acetylcarnitine
is: SBO:0000247
is: CHEBI:57589
has only substance units: false
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false

metaM succ c
is: SBO:0000247
is: C00042
initial amount: NaN
boundary condition: false
name: Succinate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
type: Species
is: HMDB00254
is: CHEBI:30031

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:26174
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
type: Species

metaR r1595
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_72a509aa_5587_4d7c_a5db_c271a243c8e3
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: PRDX2
boundary condition: true
type: Species
is encoded by: hsa:7001

metaR r2519
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
reversible: true
reactant: MODEL1310110049#
name: Utilized transport
fast: false
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction

metaM mal L m
constant: false
is: CHEBI:15589
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial amount: NaN
name: (S)-malate(2-)
initial concentration: 1.0
has only substance units: false
is: HMDB00156

http://identifiers.org/biomodels.db/MODEL1310110049#_1b13886f_9deb_4c49_aa3d_5e7e80588a75
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9NTN3
name: SLC35D1
boundary condition: true
is encoded by: hsa:23169

http://identifiers.org/biomodels.db/MODEL1310110049#_276cf766_693d_47ce_973b_1419fdfe648d
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110049#_94f2efb5_c209_4d9f_aff3_e8db47eb9ec2
name: _BE966236_1_c
is encoded by: hsa:BE966236
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM gbside hs l
type: Species
constant: false
initial concentration: 1.0
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ca2b2c4c_1bf8_41b9_a887_85c49c6af5d1
initial concentration: NaN
is encoded by: hsa:284273
initial amount: NaN
constant: false
type: Species
is: Q4G1C4
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ZADH2

metaM mal L x
name: (S)-malate(2-)
type: Species
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
initial concentration: 1.0

metaM triodthy c
is: HMDB00265
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
boundary condition: false
is: CHEBI:18258
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_c1a1f5ed_0cb3_43f5_964f_d3c09d2824eb
type: Species
is encoded by: hsa:3141
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: P50747
name: HLCS
is: SBO:0000252

metaM h2o2 x
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
constant: false
is: SBO:0000247
name: Hydrogen peroxide
is: C00027
boundary condition: false
is: HMDB03125
has only substance units: false
is: CHEBI:16240
initial amount: NaN

metaR LNLCCRNt
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110049#
reversible: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaM ksi deg35 l
name: keratan sulfate I, degradation product 35
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
constant: false
is: HMDB00143
type: Species
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
is: SBO:0000247

metaR r1487
name: EC:6.2.1.3
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_057575b4_9488_4bac_b156_49eeb755eb5a
constant: false
is: SBO:0000252
is: O43306
type: Species
name: ADCY6
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:112

metaM ptdcacoa c
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB06499
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: pentadecanoyl Coenzyme A
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1

metaM m3mpdol U c
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:37632
boundary condition: false
initial amount: NaN
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
constant: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
has only substance units: false

metaM f1a g
name: F1alpha
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: CHEBI:15936

metaM dcholcoa r
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
type: Species
is: HMDB06292
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
initial amount: NaN

metaM pe hs c
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: phosphatidylethanolamine
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN

metaR CYTK10
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
fast: false
name: cytidylate kinase (CMP,dGTP)

metaM m5masnC g
is: HMDB06814
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: CHEBI:58401
boundary condition: false
constant: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial concentration: 1.0

metaR 4ABUTtm
reversible: true
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: 4-aminobutanoate mitochondrial transport via diffusion
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
type: Reaction

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaM oaa c
is: HMDB00223
is: CHEBI:3338
is: C00036
name: Oxaloacetate
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_92e37899_65df_48ed_84b0_8eba09c1e6f6
type: Species
is encoded by: hsa:28231
initial concentration: NaN
name: SLCO4A1
initial amount: NaN
is: SBO:0000252
is: Q96BD0
has only substance units: false
constant: false
boundary condition: true

metaM acrn m
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57589
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
name: O-acetylcarnitine
is: SBO:0000247
is: HMDB00201
type: Species
constant: false

metaR LINKDEG3ly
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: false
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaR HAS2
is version of: http://identifiers.org/ec-code/2.4.1.212
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
name: hyaluronan synthase
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110049#
reversible: false
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#

metaM c226coa m
is: C16169
has only substance units: false
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN

metaR r1630
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
name: nLc8Cer
has only substance units: false
constant: false
is: CHEBI:26174
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110049#_e5082af2_aa7c_430e_b8d6_aba0ffb892a0
is encoded by: hsa:2819
has only substance units: false
name: GPD1
constant: false
type: Species
initial amount: NaN
is: F8W1L5
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR CYTK11
reactant: MODEL1310110049#
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110049#
name: cytidylate kinase (dCMP,dGTP)

metaM triodthy e
initial amount: NaN
is: HMDB00265
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ca85233a_29be_4f23_8693_c445ce55515d
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6785
is: Q9GZR5
type: Species
name: ELOVL4
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR CHOLtu
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#
name: Choline uniport
reactant: MODEL1310110049#

metaR PRAGSr
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110049#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.2
reversible: true
name: phosphoribosylglycinamide synthase

metaM core6 l
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00143
name: Core 6
is: CHEBI:12936
constant: false
type: Species

metaR CYTK9
fast: false
reactant: MODEL1310110049#
type: Reaction
name: cytidylate kinase (CMP,dCTP)
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000269

metaR XOL27OHtm
is described by: ECO:0000000
name: 27 hydroxy cholesterol transport
reactant: MODEL1310110049#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110049#
reversible: true

metaM pe hs e
initial concentration: 1.0
constant: false
is: CHEBI:16038
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine

metaM pmtcrn c
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
name: L-palmitoylcarnitine
is: HMDB00222
type: Species
is: SBO:0000247
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN

metaR CYTK12
is: SBO:0000176
reactant: MODEL1310110049#
product: MODEL1310110049#
name: cytidylate kinase (dCMP,dCTP)
modifier: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110049#

metaM m5mpdol U r
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
type: Species
is: CHEBI:37634
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM fad m
is: C00016
constant: false
initial concentration: 1.0
is: HMDB01248
has only substance units: false
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

metaR PPItr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
product: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_8ceefb9f_e138_4a05_925a_660a9e06bc5e
is: SBO:0000252
boundary condition: true
name: ACOT7
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:11332
initial amount: NaN
is: O00154

http://identifiers.org/biomodels.db/MODEL1310110049#_e36646d1_93b8_46a6_b9c4_63066c720757
type: Species
is encoded by: hsa:441024
has only substance units: false
boundary condition: true
name: MTHFD2L
initial amount: NaN
is: Q9H903
constant: false
is: SBO:0000252
initial concentration: NaN

metaR ARACHDtr
kinetic law: MODEL1310110049#
is described by: ECO:0000000
name: intracellular transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_2152013b_f161_4ee5_b080_2c092317c7d5
name: PHPT1
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:29085
is: Q9P019
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_7c23c7e0_5d92_44fb_a62f_2d9442e53734
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:64078
is: SBO:0000252
is: Q9HAS3
has only substance units: false
boundary condition: true
name: SLC28A3
constant: false

metaM hexdicoa r
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: HMDB00672
is: C08260
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: hexadecanedioylcoa
constant: false
type: Species

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR CYTK8
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
name: cytidylate kinase (CMP,dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#

metaR LEUKTRB4t
reactant: MODEL1310110049#
product: MODEL1310110049#
name: leukotriene B4 transport
kinetic law: MODEL1310110049#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_5e0a63e5_a6f9_475e_aa62_62e327014c20
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:84649
is: SBO:0000252
is: Q96PD7
constant: false
name: DGAT2

metaR CYTK6
product: MODEL1310110049#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM m8masn g
constant: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: C05876
has only substance units: false
is: SBO:0000247
notes: FORMULA: C70H117N2O55X CHARGE: 0

metaM ksii core4 pre9 g
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR r1633
reversible: true
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

metaR ASCBOX
type: Reaction
name: ascorbic acid oxidase
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaR CSND
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reversible: false
type: Reaction
name: Cytosine deaminase
fast: false

metaM camp c
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
type: Species
initial concentration: 1.0
is: HMDB00058
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:58165
name: 3',5'-cyclic AMP(1-)

http://identifiers.org/biomodels.db/MODEL1310110049#_e60b40f7_9c47_4a5c_8139_c75df9485c75
name: CHST5
is encoded by: hsa:23563
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: Q9GZS9
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR CYTK7
is described by: ECO:0000269
product: MODEL1310110049#
fast: false
type: Reaction
name: cytidylate kinase (CMP,UTP)
kinetic law: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110049#
reactant: MODEL1310110049#

metaM lnlc e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00673
is: CHEBI:30245
is: SBO:0000247
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
type: Species
name: linoleate

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR G6PDH2rer
type: Reaction
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is described by: ECO:0000269

metaR CYTK5
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP)
reactant: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110049#

metaR r1634
type: Reaction
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110049#

metaM core2 g
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:15876
has only substance units: false
name: Core 2
is: SBO:0000247
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0

metaR FAOXC150m
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid (odd chain)
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction

metaM hexdicoa x
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: hexadecanedioylcoa
boundary condition: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: HMDB00705
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ac369a24_cec8_4c3f_9790_86f42da7a065
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:788
name: SLC25A20
constant: false
type: Species
initial amount: NaN
is: O43772

metaM ksi deg21 l
is: HMDB00143
initial amount: NaN
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 21
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: CHEBI:12936
type: Species

metaR r0801
modifier: MODEL1310110049#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
reactant: MODEL1310110049#

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaM dhf m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: dihydrofolate(2-)
constant: false
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
is: HMDB01056
boundary condition: false
initial amount: NaN

metaM xyl D c
initial amount: NaN
has only substance units: false
is: CHEBI:15936
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
is: SBO:0000247
name: aldehydo-D-xylose

metaM HC01610 e
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial amount: NaN
has only substance units: false
name: CoproporphyrinogenI
is: CHEBI:28607
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

metaR TRDR
is version of: http://identifiers.org/ec-code/1.8.1.9
kinetic law: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
is described by: ECO:0000269
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
type: Reaction
name: thioredoxin reductase (NADPH)
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_1bb4fe0a_928d_4b7a_88d5_b56341ee43ed
initial concentration: NaN
name: B3GNT6
is encoded by: hsa:192134
type: Species
is: A8K9Q8
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR CYTK4
product: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (dCMP)(GTP)
fast: false
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3

metaR r1631
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false

metaR PPItx
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Diphosphate transporter, peroxisome
product: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaR PPNCL3
fast: false
name: phosphopantothenate-cysteine ligase
kinetic law: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.5
reactant: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000269

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM ksi pre6 g
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 6
type: Species
constant: false
is: C00130
is: HMDB00175
notes: FORMULA: C107H174N7O80SX CHARGE: -2
has only substance units: false
is: SBO:0000247

metaM gbside hs g
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
type: Species
initial amount: NaN
constant: false

metaR 2AMADPTm
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
reactant: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110049#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110049#_67d4b875_dba6_4459_939e_157eff3f2400
type: Species
name: TXNRD1
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7296
constant: false

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
constant: false
is: CHEBI:10986
is: C03492
name: D-4'-Phosphopantothenate
initial amount: NaN
is: SBO:0000247
is: HMDB01016
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaM ksi pre26 g
boundary condition: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 26
is: CHEBI:28067
initial amount: NaN
is: SBO:0000247

metaR GASNASE3ly
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000176
product: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
is described by: ECO:0000000
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110049#

metaR NACHEXA13ly
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
fast: false
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110049#
is described by: ECO:0000000

metaR CYTK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: true
name: cytidylate kinase (CMP)(GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110049#

metaR LPCHOLt
reactant: MODEL1310110049#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
name: lysophosphatidylcholine transport
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_2cffdecd_baba_4cd8_9d45_dd691e5e8937
has only substance units: false
type: Species
constant: false
is: P05062
name: ALDOB
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:229
is: SBO:0000252

metaR CYSGLNNaEx
reversible: false
fast: false
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110049#

metaR r2391
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110049#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000
is: SBO:0000185

metaR CSNAT3x
reactant: MODEL1310110049#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: carnitine O-aceyltransferase, peroxisomal
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
kinetic law: MODEL1310110049#
reversible: true
fast: false
product: MODEL1310110049#

metaM dcholcoa x
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
has only substance units: false
is: CHEBI:28701
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: HMDB06292

http://identifiers.org/biomodels.db/MODEL1310110049#_e081cf27_b62c_4459_9651_91a469fb7c65
has only substance units: false
constant: false
boundary condition: true
name: SLC5A12
is encoded by: hsa:159963
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q1EHB4

metaR r1632
type: Reaction
modifier: MODEL1310110049#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false

metaM core6 g
constant: false
type: Species
is: CHEBI:16478
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
initial amount: NaN
name: Core 6
has only substance units: false

metaR PNTOt5
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (8884.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10329687,PMID:10334869,PMID:12646417,PMID:15561972,PMID:9516450 NOTES:_01-25-05 based on Wang et al., JBC, 1999,1 274(21), 14875-14888. IT 03-07-05:replaced IT: now based on Balamurugan et al, 2005, Am J Physiol Renal Physiol, 288, F823-831,2005
name: Pantothenate sodium symporter II
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: false
fast: false

metaR PMTCOAtx
kinetic law: MODEL1310110049#
type: Reaction
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110049#

metaR r1612
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true

metaR r0249
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
reversible: true
kinetic law: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
is: SBO:0000176
reactant: MODEL1310110049#
is described by: ECO:0000000
modifier: MODEL1310110049#

metaR FADtru
fast: false
is: SBO:0000185
name: FAD transporter, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaR r0354
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110049#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: false

metaR RADH3
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: true
is described by: ECO:0000000
name: retinal dehydrogenase
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT

metaM glu L e
type: Species
constant: false
name: L-glutamate(1-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:29985
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148

http://identifiers.org/biomodels.db/MODEL1310110049#_630f54a7_a74c_4d7a_9c8a_f9cd9667cafb
boundary condition: true
initial concentration: NaN
name: SLC23A2
has only substance units: false
initial amount: NaN
is encoded by: hsa:9962
type: Species
is: SBO:0000252
constant: false

metaR G14T3g
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is: SBO:0000176

metaR r1611
is: SBO:0000185
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
reactant: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM orn e
constant: false
name: Ornithine
is: SBO:0000247
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
has only substance units: false
is: C01602
initial amount: NaN
is: CHEBI:0
type: Species
initial concentration: 1.0

metaR r0355
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110049#
product: MODEL1310110049#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3

metaM HC01496 m
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
is: CHEBI:28095
name: 2-Amino-3-oxoadipate
constant: false
boundary condition: false

metaM glyc R c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00139
has only substance units: false
name: D-glycerate
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
is: CHEBI:16659

http://identifiers.org/biomodels.db/MODEL1310110049#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
name: I-antigen
is: CHEBI:26174
type: Species
initial amount: NaN
initial concentration: 1.0

metaM asp D e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
name: D-aspartate(1-)
initial concentration: 1.0
type: Species
is: HMDB06483
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:29990
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_ebf8ffce_3524_4901_a8a2_e7afe84abe6e
is: SBO:0000252
name: PLCB2
type: Species
initial amount: NaN
is: Q59F77
is encoded by: hsa:5330
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaR r1492
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Utilized transport
type: Reaction

metaM Nacasp m
is: CHEBI:16953
has only substance units: false
is: HMDB00812
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: N-acetyl-L-aspartate(2-)
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_e1f60a63_2e48_4c8b_89a7_35862f05e0cf
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:10965
is: P49753
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACOT2
has only substance units: false

metaR 4MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110049#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Transport of 4-methyl-2-oxopentanoate

metaR CYTK1
type: Reaction
reversible: true
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110049#
fast: false
name: cytidylate kinase (CMP)
is: SBO:0000176

metaR r1614
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110049#

metaM cs c l
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
boundary condition: false
is: SBO:0000247
is: HMDB06202
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM orn c
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00214
boundary condition: false
initial concentration: 1.0
is: CHEBI:0
type: Species
is: C01602
initial amount: NaN

metaR THRSERNaEx
is described by: ECO:0000269
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
type: Reaction
fast: false
modifier: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110049#_008486e5_f996_4114_bb3f_4ebcfbe0a5e5
is: SBO:0000252
is encoded by: hsa:4697
initial amount: NaN
is: O00483
type: Species
has only substance units: false
name: NDUFA4
initial concentration: NaN
boundary condition: true
constant: false

metaR r1613
modifier: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM fol c
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: Folate
is: HMDB00121
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_7acf383b_9449_4ae3_85a6_58e4be3d4863
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4719
name: NDUFS1
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is: P28331

metaM xyl D e
is: CHEBI:15936
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: aldehydo-D-xylose
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0

metaR PHCHGSm
type: Reaction
is: SBO:0000176
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#

metaR CYTK2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: cytidylate kinase (dCMP)
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR PYK
modifier: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: false
is described by: ECO:0000134
product: MODEL1310110049#
reactant: MODEL1310110049#
name: pyruvate kinase
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaR G14Tg
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
kinetic law: MODEL1310110049#

metaM nm4masn g
initial amount: NaN
constant: false
has only substance units: false
is: C05882
is: SBO:0000247
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
notes: FORMULA: C54H90N3O40X CHARGE: 0
initial concentration: 1.0
boundary condition: false
type: Species

metaM mag hs c
is: SBO:0000247
initial amount: NaN
is: CHEBI:16987
name: monoacylglycerol 2
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
is: HMDB12130

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: C00881
name: Deoxycytidine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:15698
type: Species
is: HMDB00014
has only substance units: false
is: SBO:0000247

metaR EX ebastineoh LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxylated ebastine exchange
type: Reaction

metaM xyl D l
name: aldehydo-D-xylose
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:15936
constant: false
initial amount: NaN
initial concentration: 1.0

metaR ST8SIA12
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.99.8
fast: false
reversible: false

metaR r1616
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110049#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GALC
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.46
name: Galactocerebrosidase
reactant: MODEL1310110049#

metaM chsterol c
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
has only substance units: false
is: HMDB00067
is: CHEBI:16113
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: cholesterol
constant: false
type: Species
boundary condition: false

metaM fuc1p L c
type: Species
initial concentration: 1.0
is: HMDB01265
is: CHEBI:28319
boundary condition: false
is: SBO:0000247
name: L-Fucose 1-phosphate
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030

http://identifiers.org/biomodels.db/MODEL1310110049#_143b0335_f0c3_481c_bd5d_57a852d0218d
name: ALDH7A1
is encoded by: hsa:501
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: E7EPT3
type: Species
initial concentration: NaN

metaM ser L e
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
is: HMDB00187
name: L-serine
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM fol e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Folate
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00121
type: Species
notes: FORMULA: C19H18N7O6 CHARGE: -1

metaR r1493
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
reversible: false
fast: false
kinetic law: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
name: Utilized transport

metaR AG13T18g
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110049#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110049#
reversible: false
reactant: MODEL1310110049#
type: Reaction

metaR PSt3
reactant: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
name: phosphatidylserine transport
is: SBO:0000185
product: MODEL1310110049#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110049#

metaR ST8SIA11
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.8
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false
is described by: ECO:0000000
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR r1615
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_e434e54e_c7df_40ff_ab6b_97684b55b25f
type: Species
name: _AI480132_1_c
is encoded by: hsa:AI480132
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_9f291c9c_e048_483f_ac83_65ce63d083fc
has only substance units: false
is: Q6LEN5
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1103
is: SBO:0000252
name: CHAT
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_429a5da7_b225_49bf_9653_6e82033dd9e9
is encoded by: hsa:1384
boundary condition: true
name: CRAT
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaM mag hs e
initial amount: NaN
is: CHEBI:60479
constant: false
boundary condition: false
name: monoacylglycerol 2
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false

metaM glu L c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29985
initial amount: NaN
name: L-glutamate(1-)
is: HMDB00148
boundary condition: false
type: Species
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaR r1618
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#

metaM chsterol e
boundary condition: false
is: HMDB00067
is: CHEBI:16113
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
has only substance units: false
initial concentration: 1.0
constant: false
name: cholesterol
type: Species

metaM ser L c
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: L-serine
is: HMDB00187
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

metaM dhdascb c
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial concentration: 1.0
initial amount: NaN
is: HMDB01264
has only substance units: false
constant: false
name: dehydroascorbide(1-)
is: SBO:0000247
boundary condition: false
is: CHEBI:58070

http://identifiers.org/biomodels.db/MODEL1310110049#_d5a5a2ef_75b2_4a9a_978e_b9db16b867bd
is: SBO:0000252
constant: false
name: PNP
boundary condition: true
is encoded by: hsa:4860
has only substance units: false
is: P00491
initial concentration: NaN
initial amount: NaN
type: Species

metaR RE1691M
name: RE1691
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.1.1
fast: false
is: SBO:0000176
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
product: MODEL1310110049#

metaR r1617
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_736f99ae_346d_4dcc_a5dd_38f9571b5785
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:8706
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: B3GALNT1
is: Q8TDY1

http://identifiers.org/biomodels.db/MODEL1310110049#_72f9d791_e1a2_4a21_969a_90a047f7a531
initial amount: NaN
is encoded by: hsa:5313
boundary condition: true
name: PKLR
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaM din e
boundary condition: false
initial amount: NaN
is: C05512
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial concentration: 1.0
name: Deoxyinosine
is: CHEBI:28997
is: HMDB00071
has only substance units: false
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_e4bc153b_3c6a_46f3_805d_457b49eb8d7e
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:50484
type: Species
name: RRM2B
initial concentration: NaN
is: Q7LG56

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_136828c5_64b0_489e_841c_bf656793a5af
boundary condition: true
type: Species
is: P00918
constant: false
has only substance units: false
is encoded by: hsa:760
is: SBO:0000252
name: CA2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_f1c80e4e_c041_4d13_ad4d_96f3659c49c0
has only substance units: false
constant: false
is: P04054
initial concentration: NaN
type: Species
is: SBO:0000252
name: PLA2G1B
is encoded by: hsa:5319
boundary condition: true
initial amount: NaN

metaR HEX1
fast: false
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000134
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: hexokinase (D-glucose:ATP)
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_029cf528_82b5_461d_8c6c_109e3f605159
is: SBO:0000252
initial concentration: NaN
type: Species
is: D9HTE9
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6576
name: SLC25A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_bd20f4ff_f49a_43b0_a10a_a04637052c3d
is: SBO:0000252
has only substance units: false
type: Species
is: E2QRH8
constant: false
is encoded by: hsa:5332
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PLCB4

metaM 3ohdcoa m
type: Species
has only substance units: false
constant: false
is: CHEBI:57349
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402
initial concentration: 1.0
is: SBO:0000247
name: 3-oxopalmitoyl-CoA(4-)
initial amount: NaN

metaR RE3301C
is: SBO:0000176
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
name: RE3301
type: Reaction
kinetic law: MODEL1310110049#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.4

http://identifiers.org/biomodels.db/MODEL1310110049#_56eb663d_caa4_47b2_8783_4a09d39e7866
is: E9PEI9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4047
boundary condition: true
constant: false
initial concentration: NaN
name: LSS
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_a920f4d6_39ae_46cb_8484_5ff99165022b
is encoded by: hsa:204
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: P54819
name: AK2
has only substance units: false
is: SBO:0000252

metaR r1619
type: Reaction
modifier: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM prostge2 c
initial concentration: 1.0
boundary condition: false
is: HMDB01220
name: prostaglandin E2(1-)
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_e13296c7_b853_4d60_a706_49de7d9ffbf4
name: CA5B
is: Q9Y2D0
is encoded by: hsa:11238
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaM dhdascb e
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: dehydroascorbide(1-)
is: CHEBI:58070
type: Species
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: HMDB01264

metaR r0242
modifier: MODEL1310110049#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
type: Reaction
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_d477d5d0_9363_4067_a1e5_f1d02b348f49
is encoded by: hsa:222
is: P48448
name: ALDH3B2
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaM din c
type: Species
is: SBO:0000247
constant: false
is: CHEBI:28997
initial amount: NaN
is: C05512
initial concentration: 1.0
is: HMDB00071
has only substance units: false
name: Deoxyinosine
boundary condition: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512

http://identifiers.org/biomodels.db/MODEL1310110049#_53c5d24f_ed33_453f_8caf_d18279542267
constant: false
has only substance units: false
boundary condition: true
name: PDE11A
initial amount: NaN
is: Q9HCR9
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:50940
type: Species

metaM fe2 e
type: Species
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
is: HMDB00692
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Fe2+
has only substance units: false
is: C00023

metaR BAAT2x
reversible: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110049#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
kinetic law: MODEL1310110049#
is described by: ECO:0000269

metaR r2514
name: Utilized transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110049#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110049#

metaR FACOAL150
name: fatty-acid--CoA ligase
is described by: ECO:0000000
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR

metaM fol m
name: Folate
type: Species
is: HMDB00121
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
is: SBO:0000247
is: CHEBI:27470

http://identifiers.org/biomodels.db/MODEL1310110049#_bb91a896_dfc3_42ac_adf4_12d9b6e48e52
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O00754
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4125
initial amount: NaN
name: MAN2B1

http://identifiers.org/biomodels.db/MODEL1310110049#_63fdc303_ce20_467a_afaf_e26d6c512ca6
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110049#_0bd8a788_0ed8_4eaf_b039_1dd28748547c
initial concentration: NaN
type: Species
is: P35219
constant: false
is: SBO:0000252
name: CA8
is encoded by: hsa:767
has only substance units: false
boundary condition: true
initial amount: NaN

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_d9e4ac3e_c985_47b8_8e98_bc7b61ff2ef8
type: Species
is: Q8TCD5
is encoded by: hsa:30833
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: NT5C

http://identifiers.org/biomodels.db/MODEL1310110049#_659de567_5e20_4e9b_b7a6_edd0fcde4650
initial amount: NaN
boundary condition: true
name: _R33828_1_c
is encoded by: hsa:R33828
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR GLCAASE9ly
name: beta-glucuronidase, lysosomal
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
fast: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_8a5e7170_ba18_4672_a75e_696cab017fe6
is encoded by: hsa:5281
name: PIGF:PIGO
constant: false
has part: Q07326
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000297
has part: Q8TEQ8
initial amount: NaN
boundary condition: true
is encoded by: hsa:84720

http://identifiers.org/biomodels.db/MODEL1310110049#_b46390b3_8be5_41f3_bb40_4cdcc4e934ca
constant: false
initial amount: NaN
is: SBO:0000252
name: ENPP1
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5167
boundary condition: true
is: P22413

http://identifiers.org/biomodels.db/MODEL1310110049#_cb94eb14_dab8_4d2b_97af_b309b7280ad5
has only substance units: false
initial amount: NaN
constant: false
name: GALT
boundary condition: true
is encoded by: hsa:2592
is: SBO:0000252
type: Species
initial concentration: NaN
is: B4E097

metaM glyc R m
is: CHEBI:16659
type: Species
is: HMDB00139
initial amount: NaN
name: D-glycerate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_cf3da9ec_bf1a_4aa3_9a26_8bf7528d61f8
initial amount: NaN
is: Q8WUX1
initial concentration: NaN
type: Species
is encoded by: hsa:92745
has only substance units: false
name: SLC38A5
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_ef458a62_a79d_43ae_a85c_c17b027a70a3
name: SLC7A8:SLC3A2
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:23428
initial amount: NaN
has only substance units: false
is: SBO:0000297
has part: Q9UHI5

metaM ksii core2 pre1 g
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 1
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28067
notes: FORMULA: C33H53N3O23X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110049#_448acc2d_3f78_4c3f_a1fe_81188e9e87a6
is: SBO:0000252
constant: false
is: O43868
is encoded by: hsa:9153
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC28A2
initial concentration: NaN
type: Species

metaM dcamp c
initial concentration: 1.0
boundary condition: false
is: CHEBI:57567
has only substance units: false
is: SBO:0000247
type: Species
name: N6-(1,2-Dicarboxyethyl)-AMP
is: HMDB00536
initial amount: NaN
constant: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: C03794

metaM Nacasp c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00812
constant: false
has only substance units: false
type: Species
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
name: N-acetyl-L-aspartate(2-)

http://identifiers.org/biomodels.db/MODEL1310110049#_de4ac982_2d42_48aa_9680_40661b4c572c
initial concentration: NaN
is encoded by: hsa:1809
boundary condition: true
name: DPYSL3
is: Q8IXW6
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_b79dd0fa_d1fe_4a20_a209_4f86f7916fb2
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:23556
has only substance units: false
type: Species
is: O95427
name: PIGN
boundary condition: true

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM fe2 c
is: C00023
type: Species
is: CHEBI:29033
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00692
has only substance units: false
name: Fe2+
initial amount: NaN
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

http://identifiers.org/biomodels.db/MODEL1310110049#_790f52e8_e318_4eb8_8ad8_ef7275eaf12b
is: SBO:0000252
name: CA6
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:765
is: Q5FC00
boundary condition: true
has only substance units: false
constant: false

metaM his L m
is: HMDB00177
boundary condition: false
initial concentration: 1.0
name: L-histidine
has only substance units: false
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_d503b206_c11d_4818_aa42_8e7a11d39505
boundary condition: true
type: Species
initial amount: NaN
is: E2QC23
is: SBO:0000252
name: GCAT
is encoded by: hsa:23464
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_616b9f38_6b1c_4a32_84d8_716fd11b71b8
has only substance units: false
constant: false
is: SBO:0000252
is: P36959
initial amount: NaN
name: GMPR
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2766
type: Species

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR ADK1m
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110049#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
name: adenylate kinase, mitochondrial
type: Reaction

metaM asp D c
is: CHEBI:29990
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial amount: NaN
has only substance units: false
name: D-aspartate(1-)
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB06483
is: SBO:0000247

metaR MMTSADm
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
type: Reaction
fast: false
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
reversible: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176

metaR r0245
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reactant: MODEL1310110049#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
kinetic law: MODEL1310110049#
product: MODEL1310110049#
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR SUCCtp
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
is: SBO:0000185
reversible: true
name: succinate transporter, peroxisome

metaM leuktrB4 c
constant: false
is: HMDB01085
name: leukotriene B4(1-)
is: CHEBI:57461
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR r0668
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.19
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: true
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is described by: ECO:0000000
fast: false
product: MODEL1310110049#
reactant: MODEL1310110049#

metaR r1018
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Transport reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR TALA
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.2.1.2
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
is described by: ECO:0000000
name: transaldolase
modifier: MODEL1310110049#

metaR r0246
is described by: ECO:0000000
reversible: false
product: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110049#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
type: Reaction
modifier: MODEL1310110049#
is: SBO:0000176
fast: false

metaM phe L e
has only substance units: false
type: Species
name: L-phenylalanine
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17295
boundary condition: false
is: HMDB00159
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_8356ca16_0e6f_4f80_a428_83eb1cb8b720
type: Species
constant: false
initial concentration: NaN
is: Q59EH3
is encoded by: hsa:52
has only substance units: false
initial amount: NaN
name: ACP1
is: SBO:0000252
boundary condition: true

metaM mal L e
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
type: Species
initial concentration: 1.0
is: CHEBI:15589
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00156
is: SBO:0000247
constant: false
name: (S)-malate(2-)

http://identifiers.org/biomodels.db/MODEL1310110049#_2d68a73b_35e9_4db8_b8b0_e8485afd0064
is encoded by: hsa:84701
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q96KJ9
boundary condition: true
name: COX4I2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_b2059ee4_b431_4406_94d9_6674f270d5f5
initial amount: NaN
boundary condition: true
is encoded by: hsa:54963
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: Q53HM1
name: UCKL1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_a6bad3d8_61b4_436b_a78a_f73426de9992
has only substance units: false
type: Species
is encoded by: hsa:AI934540
initial concentration: NaN
is: SBO:0000252
constant: false
name: _AI934540_1_c
initial amount: NaN
boundary condition: true

metaM chsterol m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: HMDB00067
initial amount: NaN
name: cholesterol
is: CHEBI:16113

metaR HEX4
is: SBO:0000176
name: hexokinase (D-mannose:ATP)
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
fast: false
product: MODEL1310110049#
is described by: ECO:0000304
reactant: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2

http://identifiers.org/biomodels.db/MODEL1310110049#_b46c489d_7cd3_4cce_8539_d2de67bb1aa0
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P14410
name: SI
constant: false
type: Species
has only substance units: false
is encoded by: hsa:6476

metaR S6T4g
type: Reaction
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
fast: false

metaR r1019
reactant: MODEL1310110049#
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR r0669
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: false
is described by: ECO:0000000
product: MODEL1310110049#
reactant: MODEL1310110049#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17

metaR INSTt4
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
name: inositol transport via sodium symport
reversible: true
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269

metaM 3mb2coa m
boundary condition: false
initial amount: NaN
is: CHEBI:57344
has only substance units: false
constant: false
is: HMDB01493
name: 3-methylbut-2-enoyl-CoA(4-)
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069

metaM phe L c
name: L-phenylalanine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00159
constant: false
is: CHEBI:17295
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079

metaM chsterol l
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
name: cholesterol
is: SBO:0000247
is: CHEBI:16113
type: Species
initial concentration: 1.0

metaM 3oddcoa x
is: SBO:0000247
name: 3-Oxododecanoyl-CoA
constant: false
initial amount: NaN
is: CHEBI:27868
boundary condition: false
has only substance units: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial concentration: 1.0
is: HMDB03937
type: Species

metaM leuktrB4 e
constant: false
initial amount: NaN
is: HMDB01085
is: CHEBI:57461
name: leukotriene B4(1-)
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
boundary condition: false

metaM hmgcoa c
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: HMDB01375
is: CHEBI:15467
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
initial amount: NaN

metaR GALNTg
is described by: ECO:0000000
modifier: MODEL1310110049#
type: Reaction
fast: false
name: GalNAc transferase, Golgi apparatus
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is: SBO:0000176
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.41
reversible: false

metaM HC01842 c
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:31997
name: Phosphodimethylethanolamine
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110049#_212bc3ce_322d_4838_aab2_e57d76a9e007
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:203
name: AK1
is: SBO:0000252
boundary condition: true
is: P00568
type: Species
initial amount: NaN

metaR MTHFD2m
type: Reaction
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000254
reversible: true

metaM mal L c
initial concentration: 1.0
is: CHEBI:15589
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
constant: false
type: Species
name: (S)-malate(2-)
initial amount: NaN
is: HMDB00156
boundary condition: false
has only substance units: false

metaR TSULt4 3
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000269
name: thiosulfate transport via sodium symport
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
product: MODEL1310110049#
fast: false
is: SBO:0000185

metaM core3 g
constant: false
boundary condition: false
type: Species
name: Core 3
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16250
notes: FORMULA: C16H27N2O10X CHARGE: 0

metaR r0086
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.1.3
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_e7817a1d_b124_4235_ab84_7318cf99848c
initial amount: NaN
is encoded by: hsa:6534
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SLC6A7
is: Q99884

metaR ACGAMPM
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/5.4.2.3
modifier: MODEL1310110049#
fast: false
type: Reaction
reversible: true
name: phosphoacetylglucosamine mutase
is described by: ECO:0000269
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
reactant: MODEL1310110049#

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.18
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
name: Propenoyl-CoA hydrolase (m)
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
modifier: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_1cc14771_30ee_4a7f_8937_ec8baec33655
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:23556
has only substance units: false
name: PIGN

http://identifiers.org/biomodels.db/MODEL1310110049#_89d877df_2081_46bc_a0e5_f9b92a0368ca
initial amount: NaN
type: Species
is encoded by: hsa:443
has only substance units: false
is: Q6FH48
name: ASPA
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaM dcyt n
type: Species
is: HMDB00014
is: CHEBI:15698
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 2'-deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_5dac47ac_8bd4_458a_9876_3584d8ccaa00
initial amount: NaN
is: SBO:0000252
is: Q7Z364
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: PDE1B
type: Species
is encoded by: hsa:5153

metaM 4nph c
is: HMDB01232
is: SBO:0000247
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
initial concentration: 1.0
name: 4-nitrophenolate
type: Species
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57917

metaR r0085
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
kinetic law: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
modifier: MODEL1310110049#
fast: false
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000

metaM ksii core4 pre8 g
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 8
is: CHEBI:58053
boundary condition: false
type: Species
initial concentration: 1.0
is: C00130
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00175
notes: FORMULA: C83H134N7O61SX CHARGE: -2

metaR ILETA
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
name: isoleucine transaminase
type: Reaction
is: SBO:0000176

metaR TCHOLAte
product: MODEL1310110049#
is: SBO:0000185
name: bile acid intracellular transport
reactant: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
kinetic law: MODEL1310110049#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_9073d38b_518c_4544_8f3d_7f687eae4124
is: Q5JZF5
constant: false
name: ALAS2
initial amount: NaN
is encoded by: hsa:212
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaR ACGALtlg
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
reversible: true
name: N-acetyl-galactosamine intracellular transport
fast: false
kinetic law: MODEL1310110049#

metaR AG13T7g
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110049#
fast: false
is: SBO:0000176
reactant: MODEL1310110049#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110049#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_0907f210_fbe8_4ef3_8f28_0a3e09e4d402
is: SBO:0000252
initial amount: NaN
name: ALG1
type: Species
is: Q9BT22
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56052
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_b81d807e_cba9_4a46_af2d_794a21b51611
is: SBO:0000252
is: Q6I9V2
has only substance units: false
name: ATP5C1
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:509
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_aa213b5f_f29f_477d_a6ef_5c96558eaefc
initial amount: NaN
name: NUDT12
type: Species
is encoded by: hsa:83594
has only substance units: false
is: SBO:0000252
constant: false
is: Q9BQG2
initial concentration: NaN
boundary condition: true

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR HEX7
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110049#
name: hexokinase (D-fructose:ATP)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110049#
reversible: false
product: MODEL1310110049#
is described by: ECO:0000304

metaM r1p c
has only substance units: false
name: alpha-D-Ribose 1-phosphate
type: Species
boundary condition: false
initial amount: NaN
is: C00442
constant: false
is: CHEBI:57720
is: SBO:0000247
is: HMDB01489
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442

metaR EBASTINEOHtr
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110049#
fast: false
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
type: Reaction
kinetic law: MODEL1310110049#

metaR RE3347C
is: SBO:0000176
kinetic law: MODEL1310110049#
name: RE3347
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
product: MODEL1310110049#

metaR LNSTLSr
fast: false
modifier: MODEL1310110049#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.99.7
name: lanosterol synthase
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: false
product: MODEL1310110049#
is described by: ECO:0000134

metaM 4nph e
type: Species
is: HMDB01232
constant: false
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 4-nitrophenolate

metaM acald m
has only substance units: false
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
type: Species
is: HMDB00990
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:15343
is: SBO:0000247
constant: false

metaR DADA
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110049#
reversible: false
product: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
is described by: ECO:0000269
name: Deoxyadenosine deaminase
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
fast: false
type: Reaction

metaR r0946
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR B MANNASEly
is version of: http://identifiers.org/ec-code/3.2.1.25
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#
name: beta-mannosidase, lysosomal
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_beb5251b_7469_45c0_815e_2940e43cfdc9
name: SLC25A2
constant: false
is encoded by: hsa:83884
boundary condition: true
initial concentration: NaN
is: Q9BXI2
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_42099959_6bab_4690_acae_85a6bb36b7fc
is: Q96G03
name: PGM2
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:55276
has only substance units: false
is: SBO:0000252

metaM ksii core2 pre9 g
has only substance units: false
initial amount: NaN
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
constant: false
name: keratan sulfate II biosynthesis, precursor 9
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_745614fa_3779_4646_a99c_56fd959425d6
constant: false
initial concentration: NaN
is encoded by: hsa:55350
is: SBO:0000297
name: VNN3:VNN2:VNN1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

metaR HMGCOARc
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
type: Reaction
reactant: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
reversible: false
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000134
fast: false
product: MODEL1310110049#
is: SBO:0000176

metaR RE0830C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reversible: true
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
reactant: MODEL1310110049#
name: RE0830
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000176

metaR r1010
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110049#
reversible: true
fast: false
name: Postulated transport reaction
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
product: MODEL1310110049#

metaR GALU
type: Reaction
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000176
product: MODEL1310110049#
fast: false
name: UTP-glucose-1-phosphate uridylyltransferase
reactant: MODEL1310110049#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.9

http://identifiers.org/biomodels.db/MODEL1310110049#_3b80a08e_6f9a_4676_b778_304a471bbdce
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: B3GALT5
boundary condition: true
is encoded by: hsa:10317
is: SBO:0000252

metaR PI34P5K
is described by: ECO:0000000
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110049#
type: Reaction
reversible: false
fast: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110049#
is: SBO:0000176

metaM 3mop c
type: Species
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial concentration: 1.0
constant: false
is: CHEBI:28654
boundary condition: false

metaR H2Ot
product: MODEL1310110049#
is described by: ECO:0000269
modifier: MODEL1310110049#
fast: false
reversible: true
kinetic law: MODEL1310110049#
is: SBO:0000185
name: H2O transport via diffusion
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_401bb484_6351_431f_b7ab_bce68e3c0587
is encoded by: hsa:570
type: Species
initial concentration: NaN
name: BAAT
is: SBO:0000252
constant: false
initial amount: NaN
is: Q14032
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_9f9f7118_a479_4747_be40_6e80c8e72f0c
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:26289
constant: false
name: AK5
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_f5bea591_c801_4dbe_a59b_a41c4e15cb0d
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:116369
has only substance units: false
initial concentration: NaN
name: SLC26A8
is: SBO:0000252

metaR CYANt
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110049#
name: Cyanide transport via diffusion (extracellular to cytosol)
fast: false
reversible: true

metaR r2506
is: SBO:0000185
reactant: MODEL1310110049#
name: Utilized transport
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_d02eb0bb_50e4_4854_bfa6_2f8ee45e5e63
boundary condition: true
initial amount: NaN
name: SLC3A2:SLC7A5
has only substance units: false
is encoded by: hsa:8140
constant: false
is: SBO:0000297
type: Species
initial concentration: NaN
has part: Q8IV97

metaR r0672
fast: false
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
reactant: MODEL1310110049#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is described by: ECO:0000000
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_aa1afc67_6d2a_4106_8a5c_9ff552b9a0e7
is: Q15067
is: SBO:0000252
is encoded by: hsa:51
name: ACOX1
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_a74f1d37_2389_4798_9d0d_44b6ca6f5c40
is: SBO:0000252
is: P08195
is encoded by: hsa:6520
boundary condition: true
has only substance units: false
name: SLC3A2
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR ADA
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
is described by: ECO:0000269
name: Adenosine deaminase
kinetic law: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110049#

metaR r0944
fast: false
is: SBO:0000185
name: Active transport
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
is described by: ECO:0000000
type: Reaction

metaM ksi deg36 l
type: Species
initial amount: NaN
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 36

metaM HC01522 c
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
boundary condition: false
is: SBO:0000247
name: Gentisate aldehyde
type: Species
initial concentration: 1.0
is: CHEBI:28508

metaM 34dhpha c
initial amount: NaN
is: HMDB01336
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: SBO:0000247
type: Species
name: (3,4-dihydroxyphenyl)acetate
constant: false
is: CHEBI:17612
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR ALCD21 D
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
name: alcohol dehydrogenase (D-1,2-propanediol)
is: SBO:0000176
reactant: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
is described by: ECO:0000304
reversible: false

metaR GALT
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
name: galactose-1-phosphate uridylyltransferase
product: MODEL1310110049#
modifier: MODEL1310110049#
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_65aed200_0643_45c5_95c2_7aa9523db8a9
boundary condition: true
is encoded by: hsa:5151
has only substance units: false
type: Species
constant: false
name: PDE8A
is: SBO:0000252
initial concentration: NaN
is: H0YMZ7
initial amount: NaN

metaR NRPPHRtu
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
fast: false
reversible: true
name: Norepinephrine uniport
is described by: ECO:0000269
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
reactant: MODEL1310110049#

metaR PItx
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
name: Phosphate transporter, peroxisome
reversible: true
product: MODEL1310110049#

metaM his L e
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
name: L-histidine
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00177
constant: false
type: Species

metaR TYMSULT
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
is: SBO:0000176
reactant: MODEL1310110049#
modifier: MODEL1310110049#
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
type: Reaction
kinetic law: MODEL1310110049#
name: Tyramine Sulfotransferase
is described by: ECO:0000269

metaM apoC Lys btn c
is: HMDB00182
has only substance units: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
boundary condition: false
is: CHEBI:32551
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_db39d21c_fb09_4cd4_9080_acddcfa38054
initial amount: NaN
is: Q53H96
constant: false
initial concentration: NaN
name: PYCRL
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:65263

http://identifiers.org/biomodels.db/MODEL1310110049#_8b6378b8_8444_4e14_8b2a_287077783ccd
name: _728637_1_c
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:728637
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_dde59cb5_ce78_4e42_b3be_98a469078b0d
boundary condition: true
name: B3GNT3
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9Y2A9
is encoded by: hsa:10331
constant: false

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM prostge2 e
name: prostaglandin E2(1-)
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01220
type: Species

metaR NACHEX5ly
product: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_4e734533_b8aa_4be9_af09_25256b81828c
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:7378
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: UPP1
has only substance units: false

metaR NDPK10
name: nucleoside-diphosphate kinase (ATP:dIDP)
is described by: ECO:0000134
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#

metaM 3mop e
boundary condition: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
initial amount: NaN
constant: false
is: HMDB00491
has only substance units: false
is: CHEBI:28654
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_e486db77_51bd_4978_8080_bf78b5341f96
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PANK2
constant: false
is: Q9BZ23
initial concentration: NaN
is encoded by: hsa:80025
boundary condition: true

metaR r2508
name: Utilized transport
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_0a77c60e_4171_43f5_bedc_03f9e377589d
has only substance units: false
is encoded by: hsa:518
initial concentration: NaN
constant: false
has part: P48201
boundary condition: true
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
is: SBO:0000297

metaR DUDPtn
reactant: MODEL1310110049#
name: dUDP nuclear transport
reversible: true
type: Reaction
product: MODEL1310110049#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110049#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110049#_9f761097_9179_4cde_ba93_e32264d1d962
is: O75251
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: NDUFS7
is encoded by: hsa:374291
is: SBO:0000252
type: Species

metaR P4504F123r
is: SBO:0000176
reversible: false
product: MODEL1310110049#
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (66002.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107 NOTES:omega hydroxylation of ebastine NJ
name: cytochrome p450 4F12/4F2
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.14.14.1

http://identifiers.org/biomodels.db/MODEL1310110049#_314cecce_0a94_4a9a_87eb_add13d1b22e2
has only substance units: false
type: Species
initial concentration: NaN
is: P55084
constant: false
initial amount: NaN
name: HADHB
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3032

metaR DGK2m
reversible: true
type: Reaction
product: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
is: SBO:0000176
fast: false
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_72ec6d28_c26e_4b42_b756_952af8ece14a
is encoded by: hsa:8228
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: PNPLA4
is: SBO:0000252
boundary condition: true
is: P41247
constant: false

metaR r0942
is described by: ECO:0000000
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9c4f0025_d181_40d3_8c24_e2c8526fdead
type: Species
is: B4DG68
is encoded by: hsa:4842
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NOS1
boundary condition: true

metaM his L c
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN
name: L-histidine
has only substance units: false
initial concentration: 1.0
is: CHEBI:15971
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00177

metaR r2509
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
name: Utilized transport
product: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false

metaM HC01434 c
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: oxalatosuccinate(3-)
type: Species
is: CHEBI:58931

http://identifiers.org/biomodels.db/MODEL1310110049#_d7166778_e613_4a9c_a4ed_2b5a822b6da9
has part: Q07837
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC7A9:SLC3A1
is encoded by: hsa:6519
constant: false
has only substance units: false
type: Species
has part: P82251
is encoded by: hsa:11136
is: SBO:0000297

metaR r0941
is described by: ECO:0000000
fast: false
reactant: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
reversible: true
name: Free diffusion
is: SBO:0000185
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:

metaR RTOTALFATPc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR H7 TAer
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
name: H7' transamidase, endoplasmic reticulum
type: Reaction
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD

metaR NH4tn
name: ammonia nuclear transport
reactant: MODEL1310110049#
is: SBO:0000185
kinetic law: MODEL1310110049#
type: Reaction
reversible: true
product: MODEL1310110049#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

metaR ADNCYC
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
is version of: http://identifiers.org/ec-code/4.6.1.1
is described by: ECO:0000269
kinetic law: MODEL1310110049#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
name: adenylate cyclase

metaM f6p c
is: HMDB00124
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57579
is: C00085
constant: false
boundary condition: false
name: D-Fructose 6-phosphate
is: http://identifiers.org/pubchem.compound/3385

metaM orn m
is: CHEBI:46912
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00214
name: Ornithine
initial amount: NaN
initial concentration: 1.0
type: Species
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false

metaR r0940
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
reversible: true
name: Free diffusion
kinetic law: MODEL1310110049#
fast: false

metaM succ x
initial amount: NaN
has only substance units: false
is: CHEBI:30031
is: SBO:0000247
is: C00042
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
type: Species
is: HMDB00254
initial concentration: 1.0
constant: false

metaR r2193
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110049#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
kinetic law: MODEL1310110049#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110049#
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_7207e5f8_da58_4eb6_badb_95f100ed477f
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6576
boundary condition: true
name: SLC25A1
initial amount: NaN
has only substance units: false
is: D9HTE9

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR 2HBO
fast: false
is described by: ECO:0000269
modifier: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reversible: true
is: SBO:0000176
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction

metaM HC01434 m
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: oxalatosuccinate(3-)
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931

http://identifiers.org/biomodels.db/MODEL1310110049#_4f06be7f_1ec8_4fcf_8136_7caf6f87785b
type: Species
is: SBO:0000252
is: Q9Y217
name: MTMR6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9107
constant: false
has only substance units: false
initial amount: NaN

metaR CRNCAR3tp
fast: false
reactant: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
name: carnitine-propcarnitine carrier, peroxisomal
type: Reaction
is described by: ECO:0000000

metaR FACOAL80i
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110049#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: fatty-acid--CoA ligase (octanoate)
is described by: ECO:0000269
modifier: MODEL1310110049#

metaM ksi deg40 l
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 40
initial amount: NaN
constant: false
is: HMDB00143
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C40H68N2O31 CHARGE: 0
initial concentration: 1.0
has only substance units: false

metaR r0670
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
fast: false
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000

metaM 2mop m
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57700
boundary condition: false
is: HMDB01172
initial amount: NaN
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_7cf17ff1_7a74_4d67_90f4_96a2cafbfbfa
initial concentration: NaN
type: Species
is: SBO:0000252
name: HSD17B10
constant: false
boundary condition: true
is: Q99714
initial amount: NaN
is encoded by: hsa:3028
has only substance units: false

metaR GALK
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.6
reversible: false
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.157
name: galactokinase
modifier: MODEL1310110049#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110049#

metaR G14T20g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000176
product: MODEL1310110049#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
reactant: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaM 3aib D m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: D-3-Amino-isobutanoate
is: HMDB02299
is: C03265
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_1d71ca67_5fc7_432f_b28c_45ad3f8dd977
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AI539321
name: _AI539321_1_c

http://identifiers.org/biomodels.db/MODEL1310110049#_f5a1d69e_f5dd_4118_8908_4e075072f2ff
is: SBO:0000252
name: ADSSL1
is encoded by: hsa:122622
has only substance units: false
initial amount: NaN
is: Q8N142
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_d57dea41_11c5_474d_9357_99ee4bbca9db
is: SBO:0000252
constant: false
is encoded by: hsa:7371
is: Q9BZX2
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: UCK2

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

metaM 5pmev c
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: (R)-5-phosphonatomevalonate(3-)
boundary condition: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
is: HMDB01343

metaM adn c
is: C00212
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16335
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
type: Species
is: HMDB00050
initial amount: NaN

metaR 4NPHSULT
name: 4-Nitrophenol Sulfotransferase
fast: false
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
modifier: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110049#
reversible: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR MANtly
name: mannose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_a1670776_a522_4698_90a2_af1b5667ac36
boundary condition: true
name: NOS1
type: Species
is encoded by: hsa:4842
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: B4DG68
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_a452fd58_e5ab_45cb_bfde_c516ab956478
name: SLC27A1
is: Q6PCB7
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:376497
initial amount: NaN
type: Species

metaR UGALNACtg
product: MODEL1310110049#
type: Reaction
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110049#

metaM gt3 hs g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
name: GT3
type: Species
is: CHEBI:28424
initial amount: NaN
has only substance units: false

metaR DM Ser Thr ly
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaR HACD1m
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is described by: ECO:0000134
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_6dd11cc8_1971_48c6_8d06_d0ab09fa5a2e
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:3612
name: IMPA1
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: B7Z6Q4

metaM apoC Lys btn m
is: SBO:0000247
boundary condition: false
is: C05552
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: HMDB03134

metaR N2M2NMASNtly
reactant: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reversible: false
name: n2m2nmasn transport, extracellular to lysosome
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR r0082
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.2
reactant: MODEL1310110049#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110049#
reversible: true
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_9b4908c6_b672_4908_bbb3_1276b68a4df4
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: FUK
initial concentration: NaN
type: Species
is: Q8N0W3
is: SBO:0000252
is encoded by: hsa:197258

metaM ser L m
boundary condition: false
is: HMDB00187
is: SBO:0000247
initial concentration: 1.0
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
is: CHEBI:17115
has only substance units: false
type: Species
initial amount: NaN

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_3be7594e_30cb_4112_8694_c9cb740cf0f7
initial concentration: NaN
constant: false
is encoded by: hsa:284129
has only substance units: false
initial amount: NaN
is: Q86WA9
type: Species
boundary condition: true
is: SBO:0000252
name: SLC26A11

metaR r1620
fast: false
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110049#

metaR r0081
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110049#

metaM adn e
is: C00212
is: CHEBI:16335
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: Adenosine
is: HMDB00050
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_64feddd4_97e2_4089_ba0b_236d7b8ae50c
type: Species
is: SBO:0000297
is encoded by: hsa:9551
initial concentration: NaN
initial amount: NaN
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
has only substance units: false
is encoded by: hsa:522
has part: P56134

metaR 4NPHte
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
kinetic law: MODEL1310110049#
name: xenobiotic transport
reversible: true
product: MODEL1310110049#

metaR NH4tp
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
name: ammonia peroxisomal transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_ffa78c0a_96f7_4bb7_b6f4_a0ea0bb58e00
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5151
has only substance units: false
name: PDE8A
is: O60658
constant: false

metaR ACCOALm
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
is: SBO:0000176
fast: false
kinetic law: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000304
modifier: MODEL1310110049#
product: MODEL1310110049#
reversible: false
name: acetate-CoA ligase (AMP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.1

metaR VD3
kinetic law: MODEL1310110049#
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110049#
name: Vitamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110049#

metaR r0084
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
fast: false
reactant: MODEL1310110049#
modifier: MODEL1310110049#
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaR r1621
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110049#_710ccc77_1892_4008_9d9a_666d43ca62a4
is: SBO:0000252
type: Species
is encoded by: hsa:763
constant: false
initial amount: NaN
name: CA5A
boundary condition: true
has only substance units: false
is: P35218
initial concentration: NaN

metaR G14T4g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110049#
product: MODEL1310110049#
fast: false
type: Reaction
kinetic law: MODEL1310110049#
is: SBO:0000176
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false

metaR RE0830N
type: Reaction
name: RE0830
product: MODEL1310110049#
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
modifier: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_d34ec4d7_5a89_46fd_b318_386351f77fb4
initial concentration: NaN
name: GPX4
type: Species
is encoded by: hsa:2879
is: P36969
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_a74b1f73_478b_4af9_9591_3468456aa784
initial concentration: NaN
constant: false
name: NDUFB3
boundary condition: true
is encoded by: hsa:4709
is: SBO:0000252
initial amount: NaN
type: Species
is: Q6IB80
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_86dd974e_e795_46df_85a8_ef034a5e3348
is: P11168
constant: false
boundary condition: true
name: SLC2A2
initial amount: NaN
is encoded by: hsa:6514
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_3df7624b_1d95_4168_9d80_0fc4bef5b3ba
is: SBO:0000252
initial amount: NaN
name: _AI191472_1_c
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AI191472
has only substance units: false
type: Species

metaR r1622
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110049#

metaM xylt c
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: HMDB02917
name: xylitol
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: SBO:0000247
boundary condition: false

metaR r0083
product: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
fast: false
reactant: MODEL1310110049#
reversible: true
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000
type: Reaction
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR GCHOLAte
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
kinetic law: MODEL1310110049#
name: bile acid intracellular transport
reactant: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_847c4803_90e4_43d5_80a5_d336a8c32315
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: B3KQH0
initial concentration: NaN
name: SLC35C1
is: SBO:0000252
is encoded by: hsa:55343

metaM dcdp m
is: CHEBI:58593
name: dCDP(3-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
boundary condition: false
type: Species
is: HMDB01245

http://identifiers.org/biomodels.db/MODEL1310110049#_a2a701b9_0d59_40b7_84bf_9c06adbc500d
name: PIGP
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51227
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR r2435
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
product: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
is: SBO:0000185

metaM cit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
is: HMDB00094
boundary condition: false
is: CHEBI:16947
is: C00158
is: SBO:0000247
constant: false
type: Species
name: Citrate
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_2770a69d_b127_4269_992b_215c0642803a
has part: Q99643
initial amount: NaN
is encoded by: hsa:6392
is encoded by: hsa:6389
is: SBO:0000297
has part: P31040
name: SDHA:SDHB:SDHC:SDHD
has only substance units: false
is encoded by: hsa:6391
initial concentration: NaN
has part: O14521
boundary condition: true
type: Species
has part: P21912
is encoded by: hsa:6390
constant: false

http://identifiers.org/biomodels.db/MODEL1310110049#_9ef4f398_4ee3_4c32_a714_73324d2fa138
boundary condition: true
name: PCYT1A
type: Species
is encoded by: hsa:5130
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is: P49585
initial amount: NaN

metaM odecoa m
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01322
initial amount: NaN
is: CHEBI:57387
initial concentration: 1.0
constant: false
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM gal l
initial amount: NaN
is: HMDB00143
constant: false
name: D-galactose
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124

metaM ppcoa x
is: C00100
is: HMDB01275
initial amount: NaN
constant: false
has only substance units: false
name: Propanoyl-CoA
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_2ef41ff3_66b9_49b4_98ec_228094226421
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:53354
constant: false
name: PANK1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_97f4ff3f_c1a6_455c_b41a_908f4a871dbc
has only substance units: false
type: Species
name: CYP27A1
is: Q02318
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:1593

metaM udpgal g
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00302
is: CHEBI:58439
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

metaM malt e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Maltose
is: CHEBI:17306
is: C00208
initial amount: NaN
is: HMDB00163

metaR NS26T2g
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.3
reactant: MODEL1310110049#
product: MODEL1310110049#
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
fast: false
modifier: MODEL1310110049#

metaR OCCOAtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reactant: MODEL1310110049#
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110049#
fast: false

metaM bilirub e
is: CHEBI:57977
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: SBO:0000247
name: bilirubin(2-)
constant: false
has only substance units: false
is: HMDB00054
boundary condition: false
initial concentration: 1.0

metaM dcdp n
initial amount: NaN
is: HMDB01245
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:58593
name: dCDP(3-)
has only substance units: false
boundary condition: false

metaR RTOTAL2FATPc
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM ru5p D r
is: CHEBI:58121
initial amount: NaN
is: HMDB00618
type: Species
name: D-ribulose 5-phosphate(2-)
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: SBO:0000247

metaR EBASTINEOHte
type: Reaction
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
fast: false
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_a38247ec_29c8_419a_b3de_77f15b023081
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5143
type: Species
name: PDE4C
constant: false
is: SBO:0000252
boundary condition: true
is: Q7KYS4

metaR SBT Dtde
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
reversible: true
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
name: D-sorbitol transport, extracellular
fast: false

http://identifiers.org/biomodels.db/MODEL1310110049#_f14af4da_cefc_4364_ba7e_c3f8bd12c97f
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: A0PJK1
is encoded by: hsa:125206
name: SLC5A10

metaR APOCF
product: MODEL1310110049#
is: SBO:0000176
name: Apocarboxylase formation
reversible: false
type: Reaction
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism

metaM Lcystin e
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species
name: L-cystine
boundary condition: false
constant: false
is: CHEBI:16283
is: HMDB00192
initial concentration: 1.0

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM hdcea e
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
name: Hexadecenoate (n-C16:1)
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB03229
is: CHEBI:32372
has only substance units: false

metaR r2433
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110049#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
product: MODEL1310110049#
kinetic law: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR THRALANaEx
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
reversible: false
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_79a1eb76_7a0f_4110_902e_68d19f6b5875
boundary condition: true
is encoded by: hsa:2880
initial amount: NaN
constant: false
has only substance units: false
name: GPX5
initial concentration: NaN
type: Species
is: SBO:0000252
is: O75715

http://identifiers.org/biomodels.db/MODEL1310110049#_0097a7c6_1b4a_4cdf_9c49_99bb2b828f40
type: Species
name: FDFT1
is: P37268
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2222
boundary condition: true
constant: false

metaR RE1526M
is described by: ECO:0000000
reactant: MODEL1310110049#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reversible: true
name: RE1526

http://identifiers.org/biomodels.db/MODEL1310110049#_2ae37c4f_1679_43b2_85bb_1ef4fd7f5b04
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8898
name: MTMR2
is: A6NN98
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaR DMNONCOACRNCPT1
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
name: DMNONCOACRNCPT1
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_50b192c8_a412_4215_a3de_8f4496ffd08a
constant: false
name: ACOX1
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51
is: B4DK61

metaM HC01406 m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: 3-Oxooctanoyl-CoA
boundary condition: false
is: CHEBI:28264

metaM bilirub c
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
is: CHEBI:57977
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00054

metaR PNTOte
name: Transport of (R)-Pantothenate
reversible: true
reactant: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110049#
type: Reaction

metaR NCNt
type: Reaction
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-NH4+ exchange
is described by: ECO:0000269
modifier: MODEL1310110049#
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
fast: false

metaR MECOAS1m
product: MODEL1310110049#
fast: false
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
name: mesaconate--CoA ligase (GDP-forming)
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000304

metaR CYSGLUexR
is described by: ECO:0000304
reactant: MODEL1310110049#
reversible: true
fast: false
name: L-cysteine/L-glutamine reversible exchanger
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
product: MODEL1310110049#
type: Reaction

metaM gam6p c
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: CHEBI:12962
constant: false
name: D-Glucosamine 6-phosphate
boundary condition: false
is: HMDB01254
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r2434
reactant: MODEL1310110049#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false

metaR PLA2 2
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.4
fast: false
modifier: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
name: phospholipase A2

http://identifiers.org/biomodels.db/MODEL1310110049#_b1efd993_726c_4f2c_a8e2_94db57f6ce4e
is encoded by: hsa:4695
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: NDUFA2
boundary condition: true
is: O43678

metaM g1m8mpdol L r
is: C05870
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
type: Species

metaR DNDPt29m
is: SBO:0000185
fast: false
modifier: MODEL1310110049#
product: MODEL1310110049#
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
reactant: MODEL1310110049#
is described by: ECO:0000269
name: dCDP transport via dADP antiport
type: Reaction

metaM C02470 c
type: Species
is: SBO:0000247
is: HMDB00881
is: http://identifiers.org/pubchem.compound/5485
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: C02470
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
name: Xanthurenic acid
initial amount: NaN

metaR ALADGLYexR
reversible: true
product: MODEL1310110049#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: D-alanine/glycine reversible exchange
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
type: Reaction
is: SBO:0000185
is described by: ECO:0000304

metaM ptth c
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: pantetheine
is: CHEBI:16753
has only substance units: false
is: SBO:0000247
is: HMDB03426
constant: false

metaM 3dhguln c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
type: Species
name: 3-dehydro-L-gulonate
initial amount: NaN
is: CHEBI:57655
constant: false
boundary condition: false

metaR r0276
is: SBO:0000176
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.2
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
product: MODEL1310110049#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_f03f428d_1761_458a_9cf1_3fc3925995ff
name: _AI620219_1_m
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI620219
has only substance units: false
constant: false

metaM udpgal c
constant: false
name: UDP-D-galactose(2-)
boundary condition: false
is: SBO:0000247
is: HMDB00302
is: CHEBI:58439
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN

metaM retinol e
is: HMDB00305
is: CHEBI:50211
initial amount: NaN
name: retinol
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species

metaM CE2421 m
initial amount: NaN
name: (3S)-3-hydroxylinoleoyl-CoA
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
constant: false
type: Species
is: CHEBI:30623
boundary condition: false
is: HMDB02329
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM HC00591 c
is: CHEBI:16769
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
name: 2-oxoglutaramate
type: Species
initial concentration: 1.0
initial amount: NaN

metaM pchol hs c
initial amount: NaN
is: CHEBI:16110
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
boundary condition: false

metaM m4mpdol U r
initial concentration: 1.0
is: CHEBI:37633
constant: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: SBO:0000247
boundary condition: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_ff72f6d3_e034_4e07_8764_8fe16d62b96d
name: HSD3B7
initial amount: NaN
is: Q9H2F3
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:80270

metaM odecoa r
initial concentration: 1.0
is: SBO:0000247
is: HMDB01322
boundary condition: false
name: oleoyl-CoA(4-)
constant: false
type: Species
is: CHEBI:57387
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510

metaR SUCCOAPET
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR FATP2t
modifier: MODEL1310110049#
is: SBO:0000185
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
name: fatty acid electroneutral transport
fast: false
reactant: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_38d2ab09_c6b9_4074_bed0_e38a2e2e547a
constant: false
is encoded by: hsa:501
name: ALDH7A1
boundary condition: true
has only substance units: false
initial amount: NaN
is: E7EPT3
type: Species
is: SBO:0000252
initial concentration: NaN

metaM retinol c
type: Species
constant: false
is: HMDB00305
name: retinol
has only substance units: false
is: CHEBI:50211
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247

metaM nadh c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
type: Species
constant: false
boundary condition: false
is: CHEBI:57945
initial concentration: 1.0
is: HMDB01487
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_9bf5e5f7_3e5e_421a_9e47_d474ee02f769
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:1635
is: P32321
constant: false
initial concentration: NaN
name: DCTD
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_d84352d1_b3ec_4ac7_8773_ff08da73b1af
type: Species
is encoded by: hsa:490
initial concentration: NaN
has only substance units: false
name: ATP2B1
constant: false
is: P20020
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR TYRt4
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: L-tyrosine transport in via sodium symport
type: Reaction
fast: false
is described by: ECO:0000304
product: MODEL1310110049#
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_7d712dc2_00ca_4e12_8179_14358db9bde2
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q9P0Z9
initial concentration: NaN
is encoded by: hsa:51268
name: PIPOX

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
constant: false
is: CHEBI:57795
boundary condition: false
has only substance units: false

metaM CE2424 m
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB11123
is: CHEBI:28387
initial concentration: 1.0
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424

metaM pchol hs e
is: CHEBI:16110
is: SBO:0000247
name: Phosphatidylcholine
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
boundary condition: false

metaM gal e
is: C00124
is: CHEBI:0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
name: D-Galactose
initial concentration: 1.0

metaM maltpt e
is: C02052
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01296
is: http://identifiers.org/pubchem.compound/5141
is: SBO:0000247
name: maltopentaose
initial concentration: 1.0
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835

metaR RE3556C
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
name: RE3556

metaR r1418
fast: false
product: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110049#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110049#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction

metaM arg L e
has only substance units: false
is: CHEBI:32682
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB00517
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

metaR EX c8dc
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_78fffcd3_4c06_49a0_9896_3e9029f39dbe
is: Q49AT3
type: Species
is encoded by: hsa:8706
name: B3GALNT1
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaR CRNt
product: MODEL1310110049#
is: SBO:0000185
name: L-carnitine reversible transport
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reversible: true
modifier: MODEL1310110049#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110049#
fast: false

metaR RE3567C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110049#
fast: false
type: Reaction
kinetic law: MODEL1310110049#
is described by: ECO:0000000
reversible: true
product: MODEL1310110049#
name: RE3567
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110049#_9eca33ff_3c39_48e5_bf0a_3a83117c3d89
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:8394
type: Species
name: PIP5K1A
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q99755

metaM lnlnca c
initial amount: NaN
name: alpha-linolenate
initial concentration: 1.0
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01388
is: CHEBI:32387

metaR Asn X Ser Thrtr
reversible: true
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110049#
reactant: MODEL1310110049#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110049#

metaM cit e
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
is: CHEBI:16947
is: SBO:0000247
is: HMDB00094
has only substance units: false
name: citrate(3-)
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR GAMt1r
reversible: true
product: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
is described by: ECO:0000269
fast: false
name: glucosamine transport (uniport)
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
kinetic law: MODEL1310110049#
type: Reaction

metaR MM7Cbg
kinetic law: MODEL1310110049#
is described by: ECO:0000000
fast: false
product: MODEL1310110049#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is: SBO:0000176
reversible: false
reactant: MODEL1310110049#
type: Reaction
modifier: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.113

metaM arg L c
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
initial concentration: 1.0
is: HMDB00517
initial amount: NaN
constant: false
type: Species
name: L-argininium(1+)
boundary condition: false
is: CHEBI:32682
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_c124546e_8441_460f_a30f_2d09235741fb
name: SCD
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O00767
is encoded by: hsa:6319
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR GLCURtly
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110049#
name: glucuronate transport into lysososme
reactant: MODEL1310110049#
product: MODEL1310110049#
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110049#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD

http://identifiers.org/biomodels.db/MODEL1310110049#_2ec43eea_56b8_4133_95cd_1a2cf6ca57aa
is encoded by: hsa:3177
is: Q14542
has only substance units: false
initial concentration: NaN
name: SLC29A2
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_1037e731_32be_4d92_8804_6b338826c366
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2678
name: GGT1
is: P19440
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR TYMSFt
kinetic law: MODEL1310110049#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
product: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
fast: false
reversible: false
name: Tyramine O-sulfate transport (diffusion)

metaR RE2660C
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
fast: false
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_be0e36d9_f04d_40a6_83bb_1b3424b3c336
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1384
name: CRAT
constant: false
is: P43155
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110049#_a385e1e0_f228_4150_b74e_78cc2818f413
is encoded by: hsa:23632
boundary condition: true
constant: false
is: A8K3J4
initial concentration: NaN
has only substance units: false
name: CA14
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_e91ed335_6eb1_429d_82cf_1d861e05c0f1
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P31213
boundary condition: true
is: SBO:0000252
name: SRD5A2
constant: false
is encoded by: hsa:6716
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_eb050900_ad3e_4aec_9739_1d8b2e75ad99
initial amount: NaN
is: O95263
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:8622
is: SBO:0000252
type: Species
name: PDE8B
has only substance units: false

metaM pchol hs r
has only substance units: false
is: SBO:0000247
is: CHEBI:16110
boundary condition: false
type: Species
name: Phosphatidylcholine
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial concentration: 1.0
constant: false

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110049#_97ed5a95_9cf8_4c0e_bfb8_65fa8abef363
has only substance units: false
is encoded by: hsa:2589
name: GALNT1
type: Species
initial amount: NaN
constant: false
is: Q10472
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_6967c1aa_175f_4a7a_9caf_e34a5b9ff35e
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: NDUFA13
has only substance units: false
is: Q9P0J0
is: SBO:0000252
is encoded by: hsa:51079

metaR C3STDH1r
is described by: ECO:0000134
reversible: false
type: Reaction
reactant: MODEL1310110049#
is: SBO:0000176
modifier: MODEL1310110049#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170

metaM ppcoa m
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
name: Propanoyl-CoA
initial concentration: 1.0
is: HMDB01275
is: SBO:0000247
has only substance units: false
constant: false

metaR 2OXOADPTm
product: MODEL1310110049#
is described by: ECO:0000269
reactant: MODEL1310110049#
reversible: true
type: Reaction
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is: SBO:0000185
modifier: MODEL1310110049#
fast: false
name: 2-oxoadipate shuttle (cytosol/mitochondria)

metaR BTNPLm
modifier: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
product: MODEL1310110049#
kinetic law: MODEL1310110049#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism

metaM Rtotalcoa c
constant: false
initial amount: NaN
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
name: R total Coenzyme A
is: HMDB01448
initial concentration: 1.0
is: CHEBI:16189
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaM datp n
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
is: C00131
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:61404
constant: false
name: dATP
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110049#_897b7270_b8c9_4a6b_ac8f_288bc7530ca5
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:39
initial amount: NaN
has only substance units: false
name: ACAT2
boundary condition: true
is: Q9BWD1
constant: false

metaM odecoa c
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB01322
is: CHEBI:3793
has only substance units: false
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
initial amount: NaN

metaM pail345p hs c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial amount: NaN
is: CHEBI:57836
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110049#_fb80fdec_7422_4653_a03f_fc5fe5f649bd
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:221
name: ALDH3B1
boundary condition: true
type: Species
is: P43353

metaR r1649
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110049#
product: MODEL1310110049#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110049#
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is described by: ECO:0000000

metaM CE5101 m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57795
is: SBO:0000247
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
has only substance units: false
constant: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR PPD2CSPp
name: PPD2CSPp
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
product: MODEL1310110049#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110049#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110049#

metaR SPHINGStl
kinetic law: MODEL1310110049#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
is: SBO:0000185
is described by: ECO:0000000
name: sphingosine intracellular transport
product: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#

metaR KSIt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110049#
reversible: false
product: MODEL1310110049#
name: keratan sulfate I transport, golgi to extracellular
reactant: MODEL1310110049#

metaM nadh m
constant: false
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: HMDB01487
is: CHEBI:57945
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00004
is: SBO:0000247

metaM CE5788 e
has only substance units: false
initial concentration: 1.0
is: HMDB02710
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
boundary condition: false
name: kinetensin 1-7
initial amount: NaN
type: Species
constant: false
is: CHEBI:27485
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110049#_d2bff92d_a221_46c1_91d3_24c72ec3508b
initial concentration: NaN
is encoded by: hsa:218
type: Species
has only substance units: false
is: P30838
boundary condition: true
is: SBO:0000252
constant: false
name: ALDH3A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_d9e19402_5ce3_477e_a342_627c7132a95b
is: Q16706
constant: false
name: MAN2A1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4124
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_1c9ea776_6f0d_4e57_875f_69bc4b6e47f8
type: Species
initial concentration: NaN
name: NDUFA6
is encoded by: hsa:4700
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: P56556

metaM leu L m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15603
type: Species
boundary condition: false
is: HMDB00687
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
name: L-leucine

metaM b2coa m
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57332
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
is: HMDB02009
name: crotonoyl-CoA(4-)
type: Species

metaR S6T10g
modifier: MODEL1310110049#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110049#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110049#
fast: false
reactant: MODEL1310110049#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR 2DR1PP
is: SBO:0000176
reactant: MODEL1310110049#
fast: false
reversible: false
kinetic law: MODEL1310110049#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110049#

metaM no c
is: SBO:0000247
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
is: HMDB03378
type: Species
name: Nitric oxide
boundary condition: false
has only substance units: false
is: C00533
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_39b0c9ef_2f93_4bb6_a9c5_1dd93d730af2
initial amount: NaN
is: SBO:0000297
has only substance units: false
has part: P07327
constant: false
boundary condition: true
type: Species
name: ADH1A:ADH1B
initial concentration: NaN
is encoded by: hsa:124

metaM ksi pre8 g
has only substance units: false
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 8

http://identifiers.org/biomodels.db/MODEL1310110049#_58c32cb2_afe2_4118_bc25_1fb252b3a47b
initial concentration: NaN
is encoded by: hsa:5315
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: PKM2
boundary condition: true

metaM ksi deg6 l
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 6
boundary condition: false
has only substance units: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: HMDB00143
constant: false

metaM lnlnca e
is: CHEBI:32387
initial concentration: 1.0
is: SBO:0000247
constant: false
name: alpha-linolenate
has only substance units: false
boundary condition: false
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
initial amount: NaN

metaR r1647
kinetic law: MODEL1310110049#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110049#
fast: false
is described by: ECO:0000000

metaM ptth m
type: Species
is: CHEBI:16753
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB03426
has only substance units: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
initial amount: NaN
name: pantetheine

metaM hdcea r
name: palmitoleate
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
is: SBO:0000247
is: HMDB03229
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaR RE3244R
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
type: Reaction
name: RE3244
product: MODEL1310110049#
reversible: true
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#
modifier: MODEL1310110049#
fast: false

metaR B3GNT312g
product: MODEL1310110049#
type: Reaction
reactant: MODEL1310110049#
is described by: ECO:0000254
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
kinetic law: MODEL1310110049#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
modifier: MODEL1310110049#

metaR DCK2n
product: MODEL1310110049#
name: Deoxycytidine kinase, nuclear (UTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110049#
reactant: MODEL1310110049#
kinetic law: MODEL1310110049#

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM cit c
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
is: HMDB00094
constant: false
name: Citrate
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16947
is: SBO:0000247
is: C00158

metaR r1648
reversible: true
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110049#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110049#
fast: false
type: Reaction
product: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_fb6a8c6b_7833_4b64_9167_a34555953433
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: _AA629629_1_m
initial concentration: NaN
is encoded by: hsa:AA629629

metaR UGCG
type: Reaction
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.80
reactant: MODEL1310110049#
name: Ceramide glucosyltransferase
modifier: MODEL1310110049#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#

metaM taur x
is: CHEBI:15891
is: HMDB00251
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: taurine
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
type: Species

metaM no e
is: C00533
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
name: Nitric oxide
boundary condition: false
is: SBO:0000247
is: CHEBI:16480
has only substance units: false
is: HMDB03378
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_463c0848_8420_43e1_b662_893dd540f4eb
initial concentration: NaN
boundary condition: true
name: IVD
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3712
is: B3KVI7
has only substance units: false
constant: false
type: Species

metaM m7masnC g
is: SBO:0000247
type: Species
is: HMDB06814
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
constant: false
has only substance units: false
is: CHEBI:58401
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_b2cff7b4_ed04_429d_9ae9_ca925405d5db
boundary condition: true
is encoded by: hsa:1808
name: DPYSL2
is: B4DR31
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaR NACASPAH
name: N-Acetyl-L-aspartate amidohydrolase
is version of: http://identifiers.org/ec-code/3.5.1.15
fast: false
type: Reaction
product: MODEL1310110049#
reactant: MODEL1310110049#
reversible: false
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
modifier: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110049#

http://identifiers.org/biomodels.db/MODEL1310110049#_a8233da9_2681_4ed0_bcf7_14e3268bf0a3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5151
name: PDE8A
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR UDPACGALtl
is described by: ECO:0000000
product: MODEL1310110049#
name: udpacgal intracellular transport
kinetic law: MODEL1310110049#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reactant: MODEL1310110049#
fast: false
type: Reaction
reversible: true

metaR TREHe
reactant: MODEL1310110049#
is: SBO:0000176
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/3.2.1.28
fast: false
reversible: false
name: alpha,alpha-trehalase
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
type: Reaction
modifier: MODEL1310110049#
is described by: ECO:0000269
product: MODEL1310110049#

metaR SERGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
kinetic law: MODEL1310110049#
reversible: false
is described by: ECO:0000269
product: MODEL1310110049#
reactant: MODEL1310110049#
is: SBO:0000185
modifier: MODEL1310110049#
type: Reaction

metaR EX c6crn
kinetic law: MODEL1310110049#
reactant: MODEL1310110049#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaR OIVD2m
is version of: http://identifiers.org/ec-code/2.3.1.168
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110049#
reactant: MODEL1310110049#
modifier: MODEL1310110049#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110049#
reversible: false
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110049#_2c984c72_984b_428c_a0e6_421959ea57ea
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is: O95167
has only substance units: false
name: NDUFA3
initial concentration: NaN
constant: false
is encoded by: hsa:4696

metaM doldp U r
constant: false
initial concentration: 1.0
name: Dolichol diphosphate, human uterine homolog
is: CHEBI:15750
has only substance units: false
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

metaR r1658
reactant: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110049#
type: Reaction
product: MODEL1310110049#
fast: false
kinetic law: MODEL1310110049#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR CYTK1n
product: MODEL1310110049#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110049#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
fast: false
name: cytidylate kinase (CMP),nuclear
kinetic law: MODEL1310110049#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110049#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110049#_bd7af812_f57e_4040_95cc_f44d473df9cd
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10317
has only substance units: false
name: B3GALT5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110049#_6fe44006_3aa0_4024_83d0_54ff9167017b
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9517
initial amount: NaN
constant: false
name: SPTLC2
is: SBO:0000252
type: Species
is: O15270
has only substance units: false

metaR GNDer
reactant: MODEL1310110049#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
kinetic law: MODEL1310110049#
product: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is: SBO:0000176

metaR r1657
modifier: MODEL1310110049#
fast: false
is: SBO:0000185
reactant: MODEL1310110049#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110049#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110049#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM m3gacpail hs r
constant: false
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: CHEBI:16240
type: Species
is: HMDB03125
is: SBO:0000247
has only substance units: false
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
boundary condition: false
initial concentration: 1.0

metaM met L e
name: L-methionine
is: CHEBI:16643
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00696
initial amount: NaN

metaM hom L e
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false
is: SBO:0000247
is: CHEBI:15699
initial amount: NaN
type: Species
is: HMDB00719
name: L-homoserine

metaM cs c deg2 l
constant: false
is: CHEBI:15748
is: SBO:0000247
type: Species
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: HMDB00127
initial amount: NaN
boundary condition: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110049#_eaef58c2_5bca_4cba_a49d_d7799770aeba
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:1718
boundary condition: true
initial concentration: NaN
name: DHCR24
is: Q15392
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_0b0f6221_ccb0_4130_8c3b_6c9d0d32b32d
constant: false
name: MTAP
is encoded by: hsa:4507
boundary condition: true
is: Q13126
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR 4NPHSFte
name: xenobiotic transport
kinetic law: MODEL1310110049#
product: MODEL1310110049#
reversible: true
fast: false
reactant: MODEL1310110049#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110049#_fb434502_68b2_4bdf_a0f5_a295e2915773
initial amount: NaN
is: SBO:0000252
name: B4GALT2
constant: false
type: Species
is encoded by: hsa:8704
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110049#_4be8ec4f_a468_41e5_954b_82efcb5cc631
is: Q9BY49
is: SBO:0000252
is encoded by: hsa:55825
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: PECR
type: Species

http://identifiers.org/biomodels.db/MODEL1310110049#_0578b12d_aea5_466d_8b4e_85c368b6be14
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3032
initial concentration: NaN
has only substance units: false
constant: false
name: HADHB
is: P55084
is: SBO:0000252