metaM prpncoa m
initial concentration: 1.0
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: CHEBI:57367
name: acryloyl-CoA(4-)
constant: false
boundary condition: false
has only substance units: false
is: HMDB02307
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_34f2545b_32db_449e_8dd4_1de67fdc37c5
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:11181
boundary condition: true
has only substance units: false
is: O43280
name: TREH

metaM pro L e
is: SBO:0000247
name: L-proline
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
initial amount: NaN
is: HMDB00162
type: Species
has only substance units: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_4ff3b55a_1469_412b_9061_74244724b279
type: Species
initial amount: NaN
name: AMY1C
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:278
is: P04745
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_4c86fd42_90ef_4170_ac8d_62ab0e337188
type: Species
name: SYNJ2
has only substance units: false
constant: false
is: O15056
boundary condition: true
is encoded by: hsa:8871
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR AG13T12g
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110048#

metaM amp e
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
boundary condition: false
is: C00020
type: Species
is: SBO:0000247
is: HMDB00045
name: AMP
is: CHEBI:456215

metaM ksii core4 deg2 l
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
has only substance units: false
type: Species
constant: false
is: CHEBI:12936
boundary condition: false
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 2
initial concentration: 1.0

metaM phe L e
is: HMDB00159
is: CHEBI:17295
initial concentration: 1.0
has only substance units: false
name: L-phenylalanine
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_da467750_fd15_46c2_bb1e_c3563c6dc06a
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: _AA664770_1_m
is encoded by: hsa:AA664770

metaM na1 e
name: Sodium
is: CHEBI:4541
boundary condition: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: C01330
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00588
type: Species
constant: false

metaM aicar e
initial concentration: 1.0
boundary condition: false
is: HMDB01517
constant: false
is: C04677
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:58475
type: Species
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

metaR AG13T17g
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110048#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110048#
fast: false
is: SBO:0000176
modifier: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_1cce6215_57a9_46d1_8b79_09e264e513fa
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: HSD17B4
initial concentration: NaN
is: SBO:0000252
is: E9PB82
is encoded by: hsa:3295
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ce83fc65_6346_449a_9814_aaa9e65e0564
has only substance units: false
boundary condition: true
type: Species
name: SLC4A3
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6508
initial concentration: NaN

metaR r1642
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
type: Reaction
is: SBO:0000185
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM hom L e
is: SBO:0000247
type: Species
is: CHEBI:15699
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
name: L-homoserine
is: HMDB00719
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR SUCCtp
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: succinate transporter, peroxisome
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ

http://identifiers.org/biomodels.db/MODEL1310110048#_d474f08e_5254_401d_b3fc_1357d114cad8
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: TPH1
constant: false
is encoded by: hsa:7166
type: Species
has only substance units: false
is: P17752

metaR Coqe
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110048#
name: Transport of q10
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_0c23059a_4b3d_4149_b444_4f7316bac565
name: ALDH1A1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:216
is: P00352

metaM lnlccoa m
initial concentration: 1.0
name: linoleic coenzyme A
constant: false
is: SBO:0000247
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR ABUTt2r
name: 4-aminobutyrate reversible transport in via proton symport
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is described by: ECO:0000304
kinetic law: MODEL1310110048#
reversible: true
fast: false
modifier: MODEL1310110048#

metaR SRTNtu
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
product: MODEL1310110048#
name: Serotonin uniport
reversible: true
fast: false
modifier: MODEL1310110048#
is: SBO:0000185

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_0c2d1c75_d27e_45fb_a923_ccf7304006cf
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4952
name: OCRL
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaM fe3 e
is: CHEBI:29034
initial amount: NaN
type: Species
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
constant: false
name: Fe3+
boundary condition: false
is: HMDB12943
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM ksii core2 pre3 g
is: C00130
has only substance units: false
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: SBO:0000247
constant: false
name: keratan sulfate II biosynthesis, precursor 3
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_c5bf8426_57c2_4c32_ab86_0202cfb0ebcd
constant: false
name: ALG3
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10195
initial concentration: NaN
type: Species

metaM arachdcoa c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN
constant: false
name: arachidonoyl-CoA(4-)
type: Species
is: CHEBI:57368
boundary condition: false
is: HMDB06523
is: SBO:0000247

metaM phyt2ohcoa x
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
is: HMDB01295
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57334
name: 2-hydroxyphytanoyl-CoA(4-)
has only substance units: false

metaR ACACT7p
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110048#
type: Reaction

metaR FAOXC123C102m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR RE3556C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
name: RE3556
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#

metaR r0870
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.4.13
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/2.7.7.72

metaR r1641
is: SBO:0000185
modifier: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000

metaR ILETAm
reversible: true
type: Reaction
fast: false
name: isoleucine transaminase, mitochondrial
product: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_2c5be03b_a241_4959_affd_8e7dff0b5c20
is: P20674
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:9377
has only substance units: false
constant: false
name: COX5A
boundary condition: true

metaR RE0915E
modifier: MODEL1310110048#
product: MODEL1310110048#
name: RE0915
reversible: true
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.17

metaM HC02203 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:27820
type: Species
name: prostaglandin-a2
initial amount: NaN
has only substance units: false
constant: false

metaM phe L c
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
is: CHEBI:17295
name: L-phenylalanine
boundary condition: false
initial amount: NaN

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM HC02179 e
boundary condition: false
name: 20-hydroxy-arachidonate
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
has only substance units: false

metaR CYANt
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
kinetic law: MODEL1310110048#
is: SBO:0000185
reversible: true
reactant: MODEL1310110048#
type: Reaction
name: Cyanide transport via diffusion (extracellular to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110048#_55346a7a_9045_4e6c_9d6a_e3177d6dbde8
has only substance units: false
type: Species
is: B3KWF4
is encoded by: hsa:63917
boundary condition: true
initial amount: NaN
constant: false
name: GALNT11
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_8c90f4fa_0765_4a07_9742_29e58560a0ef
initial amount: NaN
type: Species
name: NDUFB8
has only substance units: false
boundary condition: true
is encoded by: hsa:4714
is: SBO:0000252
is: O95169
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_a2b699a4_5e57_4092_a901_157a36aebcfb
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AA278423
name: _AA278423_1_c
has only substance units: false
initial concentration: NaN

metaM ksi pre26 g
constant: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 26

metaM na1 c
is: HMDB00588
is: CHEBI:4541
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
has only substance units: false
is: C01330
initial amount: NaN
is: SBO:0000247
name: Sodium
type: Species

metaM aicar c
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
is: CHEBI:58475
type: Species
is: HMDB01517
is: C04677
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_8ca51a99_591f_4d23_bcfc_8b7326b32159
is encoded by: hsa:151531
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
is: O95045
name: UPP2
initial amount: NaN

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r1644
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
reversible: true
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000

metaR MAN6PI
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
fast: false
name: mannose-6-phosphate isomerase
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_de5abe5d_2e43_41d9_9ab4_40b4ab4fe5fa
initial amount: NaN
is: SBO:0000252
name: GPAA1
is encoded by: hsa:8733
type: Species
is: O43292
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaR Asn X Ser Thrtr
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
fast: false
product: MODEL1310110048#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110048#
name: Asn-X-Ser/Thr transport (from ER to lysosome)

http://identifiers.org/biomodels.db/MODEL1310110048#_f33e4509_25ac_4b5d_bc7c_821db9c33d0a
is: O60909
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8704
constant: false
name: B4GALT2

metaR P5CRm
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.2
name: pyrroline-5-carboxylate reductase (m)
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false
modifier: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000304
is: SBO:0000176

metaM leu L m
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
boundary condition: false
name: L-leucine
is: CHEBI:15603
is: SBO:0000247
is: HMDB00687
type: Species
initial concentration: 1.0
initial amount: NaN

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_b8206027_4f64_4896_8fd9_d30b66c32d8a
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:8833
is: P49915
name: GMPS
is: SBO:0000252

metaM Sfglutth c
is: SBO:0000247
name: S-formylglutathionate(1-)
is: HMDB01550
has only substance units: false
is: CHEBI:57688
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_9be51507_6944_4914_b477_bc865b4b88b3
is: Q9BXI2
has only substance units: false
name: SLC25A2
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:83884

metaR DOLASNT Uer
reversible: false
modifier: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.119
fast: false
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
type: Reaction
product: MODEL1310110048#

metaM glu5sa m
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
boundary condition: false
is: C01165
initial amount: NaN
constant: false
is: CHEBI:17232
name: L-Glutamate 5-semialdehyde
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB02104
type: Species

metaR VITD3t2
reversible: false
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
product: MODEL1310110048#
is: SBO:0000185
fast: false
name: Vitamin D3 uptake
kinetic law: MODEL1310110048#

metaM pmtcoa x
is: CHEBI:57379
is: C00154
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_6be8f0b3_e7c3_4cf5_8b21_663a1d785999
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: _AI971036_1_m
boundary condition: true
is encoded by: hsa:AI971036
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_1b36c28a_2d0f_4cfd_84dd_12f1bab41822
is: Q03393
constant: false
has only substance units: false
name: PTS
is: SBO:0000252
is encoded by: hsa:5805
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR CYTK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (dCMP),nuclear
reversible: true
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_21011e9c_f587_47e2_ac1e_aa9a66dd41ba
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: GPD1
is: SBO:0000252
type: Species
is: F8W1L5
is encoded by: hsa:2819
initial amount: NaN

metaR DRPA
is described by: ECO:0000000
name: deoxyribose-phosphate aldolase
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#

metaR FAOXC226C205m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM e4p c
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: C00279
constant: false
boundary condition: false
is: CHEBI:16897
is: HMDB01321
initial amount: NaN
name: D-Erythrose 4-phosphate

metaR S6T18g
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

metaR r1643
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110048#

metaR GLYC3PFADm
reversible: false
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110048#
kinetic law: MODEL1310110048#
name: glycerophosphate shuttle for trasnfer of reducing equivalents
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false

metaR O2Stm
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)
is: SBO:0000185
reversible: true

metaR BTNt2
modifier: MODEL1310110048#
name: Biotin reversible transport via proton symport
is: SBO:0000185
reactant: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_5258329a_e0af_4129_ac5e_303541f409b0
initial concentration: NaN
is encoded by: hsa:113235
constant: false
type: Species
is: Q96NT5
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC46A1
initial amount: NaN

metaR r1646
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_93c2a72f_31e6_4907_b378_f56d75cc4e61
has only substance units: false
is encoded by: hsa:341947
name: COX8C
is: Q7Z4L0
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_2dbee16c_6ec0_48f7_8cab_e7fb62d02de4
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7360
boundary condition: true
name: UGP2
is: SBO:0000252

metaR PROSTGI2t
name: Prostaglandin I2 transport
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_1b0a45bd_1ed2_40c2_b89b_6d2dce813ff1
is encoded by: hsa:2109
initial concentration: NaN
name: ETFA:ETFB
has part: P38117
constant: false
initial amount: NaN
type: Species
is: SBO:0000297
boundary condition: true
has only substance units: false

metaM udpglcur c
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58052
is: C00167
initial concentration: 1.0
name: UDP-D-glucuronate
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: HMDB00935
boundary condition: false
type: Species

metaR GLYPROPRO1c
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Prolylglycine in the small intestine for cellular uptake
type: Reaction

metaR DOLGPP Ler
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110048#
reversible: false
product: MODEL1310110048#
is: SBO:0000176
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_275145fb_4e51_4190_af73_c26a5d846af5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: P80404
initial amount: NaN
type: Species
boundary condition: true
name: ABAT
is encoded by: hsa:18

metaR r2060
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110048#

metaM Rtotalcoa c
is: CHEBI:16189
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
type: Species
is: SBO:0000247
is: HMDB01448
name: R total Coenzyme A
has only substance units: false
constant: false

metaR UMPK4n
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
name: UMP kinase (GTP),nuclear
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110048#
reversible: true

metaR LEUKTRD4t
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
name: leukotriene D4 transport
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true

metaR 3SPYRSPm
product: MODEL1310110048#
reversible: false
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
fast: false
is: SBO:0000176
kinetic law: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_32b04bf1_d102_4f87_8bf5_a8cfeffdb4fa
boundary condition: true
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
has only substance units: false
is encoded by: hsa:7991
type: Species
constant: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3

metaM ksi pre21 g
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 21
initial amount: NaN
constant: false
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: C00130
boundary condition: false
has only substance units: false
is: HMDB00175

metaM maltpt e
type: Species
initial amount: NaN
is: HMDB01296
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
constant: false
is: http://identifiers.org/pubchem.compound/5141
is: C02052
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: maltopentaose

http://identifiers.org/biomodels.db/MODEL1310110048#_774badc3_4555_4a29_b472_973366c3c4bf
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: DPYD
has only substance units: false
is: Q12882
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:1806

http://identifiers.org/biomodels.db/MODEL1310110048#_3db9f48c_7acf_4d12_b017_7c6d4d0c1608
boundary condition: true
type: Species
initial concentration: NaN
is: Q96SL4
is: SBO:0000252
initial amount: NaN
name: GPX7
has only substance units: false
is encoded by: hsa:2882
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_205257be_330d_4a29_a458_4ea568463796
name: NDUFB1
initial amount: NaN
has only substance units: false
is: O75438
constant: false
type: Species
is encoded by: hsa:4707
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_65e23810_e822_4f57_80f7_068c48d7238b
constant: false
initial concentration: NaN
type: Species
name: ACSL4
is encoded by: hsa:2182
initial amount: NaN
is: O60488
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r1922
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
reversible: false
reactant: MODEL1310110048#

metaR DUDPtn
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
name: dUDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_8324684c_008b_41d6_8fe6_5f6c00bfe91e
initial concentration: NaN
name: HIBCH
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:26275
type: Species
is: Q6NVY1

http://identifiers.org/biomodels.db/MODEL1310110048#_8496c66c_bfa7_4d93_bb7f_a66cbc9caf02
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: VNN3

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR r1645
modifier: MODEL1310110048#
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM hmgcoa x
initial amount: NaN
is: HMDB01375
is: SBO:0000247
constant: false
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_e936bbda_99b2_461c_a069_0de33cd1c4bf
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4645
is: Q9H6Y6
is: SBO:0000252
name: MYO5B
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b5d0c2a5_ad7b_480e_8e4f_5791b58010a9
is encoded by: hsa:4711
initial concentration: NaN
is: O43674
is: SBO:0000252
initial amount: NaN
type: Species
name: NDUFB5
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_bd1ed36e_3e40_412a_9988_92e3febd85d8
type: Species
name: SLC12A6
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9UHW9
has only substance units: false
is encoded by: hsa:9990
boundary condition: true

metaR NP1
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000304
kinetic law: MODEL1310110048#
name: nucleotide phosphatase
type: Reaction

metaM nac c
is: HMDB01488
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:0
constant: false
has only substance units: false
type: Species
is: C00253
notes: FORMULA: C6H4NO2 CHARGE: -1
name: Nicotinate

http://identifiers.org/biomodels.db/MODEL1310110048#_58430dc6_dbf5_4a31_abbd_09a30a84f438
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:8818
initial concentration: NaN
initial amount: NaN
name: DPM2
is: O94777

metaM adp x
is: CHEBI:456216
type: Species
initial concentration: 1.0
name: ADP(3-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
is: HMDB01341
boundary condition: false
has only substance units: false

metaR NDPK1n
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
reversible: true
is described by: ECO:0000134
type: Reaction

metaM amp c
type: Species
name: AMP
is: HMDB00045
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: C00020
constant: false
is: CHEBI:3322
initial concentration: 1.0
is: SBO:0000247

metaR RE1836X
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110048#
name: RE1836
reversible: true
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_424fc612_6e6e_4aa1_ae96_563bf0dc78af
initial amount: NaN
is: O43426
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8867
boundary condition: true
is: SBO:0000252
name: SYNJ1

metaR r2061
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110048#
reversible: false
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
product: MODEL1310110048#

metaR CHSTEROLtrc
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
name: transport of cholesterol into the cytosol
reactant: MODEL1310110048#

metaR r1648
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#

metaM leuktrB4 e
is: HMDB01085
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
has only substance units: false
name: leukotriene B4(1-)

metaR r1921
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#

metaR DALAt2r
reactant: MODEL1310110048#
name: D-alanine transport via proton symport
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
is: SBO:0000185
product: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000304
type: Reaction

metaM dcacoa m
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:61430
type: Species
is: HMDB06404
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
initial concentration: 1.0
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110048#_d6f23d5a_89a9_4104_a008_dd42ee20fcf4
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4723
boundary condition: true
name: NDUFV1
is: E5KNH5
constant: false
is: SBO:0000252

metaR r0494
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
product: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_b6edf22c_691c_4425_81fb_0e9bc878ec8a
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3101
boundary condition: true
is: P52790
name: HK3
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_385764ab_8c72_49ec_ac4b_a32303e13814
type: Species
is: O14832
is: SBO:0000252
name: PHYH
is encoded by: hsa:5264
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaR TCHOLAte
reversible: true
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
name: bile acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110048#

metaR S6T10g
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110048#
type: Reaction

metaM glyald m
name: D-glyceraldehyde
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01051
boundary condition: false
is: CHEBI:17378
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_99db46cc_f062_4afe_98be_4f06944a97a9
is: Q96CD2
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: PPCDC
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:60490

http://identifiers.org/biomodels.db/MODEL1310110048#_76695285_cebe_4e24_ac7d_5bb69c836c66
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: B7Z6S9
constant: false
is encoded by: hsa:2629
name: GBA

metaM thbpt4acam n
is: HMDB02281
initial amount: NaN
is: CHEBI:15374
is: SBO:0000247
boundary condition: false
name: 4a-hydroxytetrahydrobiopterin
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_9d2e44bc_11b8_4f7f_957e_7680a5449b2c
is encoded by: hsa:AI924226
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _AI924226_1_m

metaR NCNt
reactant: MODEL1310110048#
name: Na+/Ca2+-NH4+ exchange
reversible: true
product: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false

metaR r1647
fast: false
reversible: true
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3d3ba8b7_945d_4a4f_a241_db349e01a63e
is: SBO:0000252
name: _AA021081_1_r
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA021081
has only substance units: false

metaM pro D e
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16313
type: Species
name: D-proline
is: HMDB03411
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

metaR GALU
name: UTP-glucose-1-phosphate uridylyltransferase
reversible: true
is: SBO:0000176
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.7.9
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_9afbaadf_70c1_40a4_8c27_d1f9d9127d6b
has only substance units: false
name: GALNT9
initial amount: NaN
is encoded by: hsa:50614
is: SBO:0000252
type: Species
is: Q9HCQ5
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_efda2bd9_3b24_4b59_9bb1_a95136358060
boundary condition: true
initial concentration: NaN
constant: false
name: TXNRD1
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:7296
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_bb509e52_34b4_4aff_92d9_efb809e20ffd
is: SBO:0000252
name: ENTPD8
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: Q5MY95
initial concentration: NaN
is encoded by: hsa:377841

metaM ttdca c
is: SBO:0000247
is: HMDB00806
name: myristate
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:30807
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
constant: false

metaR r0400
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true

metaR CYTK11n
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110048#
name: cytidylate kinase (dCMP,dGTP),nuclear
reactant: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
type: Reaction
reversible: true
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaR r1920
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000185
modifier: MODEL1310110048#
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM damp c
has only substance units: false
is: CHEBI:58245
constant: false
is: HMDB00905
boundary condition: false
name: dAMP(2-)
initial amount: NaN
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR CHOLPtg
reactant: MODEL1310110048#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
name: choline phosphate intracellular transport
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
product: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_231c5d56_b328_4462_a527_77a4145d85e8
is: H0UI06
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:1347
constant: false
name: COX7A2
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r1378
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000176
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM glyc m
initial amount: NaN
is: HMDB00131
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
is: CHEBI:17754
type: Species
name: Glycerol
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_937688b1_ad90_4c70_b604_d960a1d3d3c8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5296
type: Species
has only substance units: false
is: O00459
boundary condition: true
constant: false
name: PIK3R2
initial amount: NaN

metaM udpacgal l
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
boundary condition: false
is: CHEBI:57847
constant: false

metaR SUCD1m
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
name: succinate dehydrogenase
type: Reaction
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110048#
is described by: ECO:0000134
reversible: true
fast: false
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_944e56ee_2416_4e6d_954b_745f7d1c8d3c
boundary condition: true
is: O00400
type: Species
initial concentration: NaN
is encoded by: hsa:9197
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC33A1

metaM phe L m
is: SBO:0000247
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
is: CHEBI:17295
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-phenylalanine
initial amount: NaN
type: Species
constant: false

metaR r1998
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DGCHOLte
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
reversible: true
name: bile acid intracellular transport
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110048#_691af192_ee03_49b4_8fb4_252018449d08
initial concentration: NaN
type: Species
name: CTPS1
boundary condition: true
is encoded by: hsa:1503
is: P17812
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR ACACT10m
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
is: SBO:0000176
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
modifier: MODEL1310110048#
fast: false
reactant: MODEL1310110048#

metaR C3STDH1r
product: MODEL1310110048#
reversible: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_4d8b912f_7ecb_4a54_a3ee_d18370a3eebc
boundary condition: true
has only substance units: false
is: Q6LEN5
is: SBO:0000252
is encoded by: hsa:1103
initial amount: NaN
constant: false
type: Species
name: CHAT
initial concentration: NaN

metaR BAAT4x
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
is described by: ECO:0000304
name: bile acid Coenzyme A: amino acid N-acyltransferase
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#

metaR KSII CORE2t
product: MODEL1310110048#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110048#
name: keratan sulfate II (core2) transport, golgi to extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR S6T4g
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction

metaM q10 m
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: HMDB01072
is: CHEBI:46245
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: ubiquinone-10
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR MG3er
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110048#_42c13a43_c854_4f29_89d3_5a020609ea80
initial amount: NaN
boundary condition: true
is: Q99643
is encoded by: hsa:6391
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: SDHC
constant: false

metaR PI5P3K
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
name: phosphatidylinositol-5-phosphate 3-kinase
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM ksi pre3 g
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
is: C00130
notes: FORMULA: C93H152N6O67X CHARGE: -1
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 3
type: Species

metaR AHEXASE2ly
reversible: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110048#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110048#_ed4a454d_1d54_43d6_a7b1_978b10d43f43
constant: false
is: Q0VAA5
is encoded by: hsa:257068
name: PLCXD2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR RE0926E
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
reactant: MODEL1310110048#

metaR r1999
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110048#
is described by: ECO:0000000

metaM gdpfuc c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial amount: NaN
initial concentration: 1.0
is: HMDB01095
constant: false
has only substance units: false
is: CHEBI:57984
name: GDP-L-fucose(2-)
type: Species

metaM melatn c
is: HMDB01389
is: CHEBI:16796
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: melatonin

metaR CBASPte
reactant: MODEL1310110048#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
name: Transport of N-carbamoyl-L-aspartate
is: SBO:0000185
type: Reaction

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaM dcacoa x
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial amount: NaN
type: Species
boundary condition: false
is: C05274
is: HMDB06404
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0

metaR PRISTtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: prist peroxisomal transport
fast: false
reactant: MODEL1310110048#
type: Reaction

metaR NDPK1m
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254

metaM HC00822 e
boundary condition: false
is: CHEBI:28681
type: Species
initial concentration: 1.0
name: Chitobiose
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR FAOXC102C101m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM 3ohdcoa x
initial amount: NaN
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349
is: HMDB06402

metaR LNSTLSr
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
fast: false
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000134
name: lanosterol synthase
is version of: http://identifiers.org/ec-code/5.4.99.7
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
kinetic law: MODEL1310110048#
reversible: false

metaR NRPPHRt4 2 r
name: Norepinephrine reversible transport in via sodium symport (1:2)
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110048#
modifier: MODEL1310110048#

metaR RE2659R
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
name: RE2659
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction

metaR PRAGSr
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
name: phosphoribosylglycinamide synthase
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.2
modifier: MODEL1310110048#
reversible: true
fast: false
is described by: ECO:0000269

metaR MAL Ltx
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is: SBO:0000185
name: Transport reaction for malate
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
fast: false

metaR 1PPDCRp
reversible: false
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reactant: MODEL1310110048#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
kinetic law: MODEL1310110048#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_da4ebae7_7f6f_4f19_8708_f10ef787885b
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: D3DX95
type: Species
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_04edcd20_2dc5_49cf_a805_ca404a7b0ddf
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
type: Species
has only substance units: false
is: SBO:0000297
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR RE3005M
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110048#
name: RE3005
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

metaR ALAATB0tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Alanine into the intestinal cells by ATB0 transporter
type: Reaction

metaM bilirub c
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
is: CHEBI:57977
name: bilirubin(2-)
initial concentration: 1.0

metaR OCDCEAtr
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110048#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaR OROTGLUt
fast: false
reversible: true
name: OROTGLUt
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction

metaR OCTAt
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
type: Reaction
name: Octanoate transport via diffusion
is: SBO:0000185
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_5254f68a_2a37_436f_8784_8546f8cd7f80
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: HK1
constant: false
is: P19367
is encoded by: hsa:3098
is: SBO:0000252
has only substance units: false

metaM eicostetcoa c
has only substance units: false
is: SBO:0000247
boundary condition: false
name: eicosatetranoyl coenzyme A
is: C16164
constant: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
type: Species
initial concentration: 1.0

metaM didp c
name: dIDP
is: CHEBI:28823
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: HMDB03536
initial concentration: 1.0

metaR r1997
is: SBO:0000185
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110048#

metaR ETFQO
is: SBO:0000176
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
is version of: http://identifiers.org/ec-code/1.5.5.1
fast: false
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
reversible: false
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#

metaR RE1531M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: RE1531
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#

metaR XOL7AH2tm
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110048#
type: Reaction
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_ec3858cf_0f37_4809_9d27_c23ea957c196
boundary condition: true
has only substance units: false
name: NDUFA4
is: SBO:0000252
constant: false
is: O00483
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4697
type: Species

metaR AG13T7g
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is: SBO:0000176
product: MODEL1310110048#
reversible: false
fast: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaM gam c
is: SBO:0000247
boundary condition: false
is: CHEBI:17315
name: D-Glucosamine
is: C00329
is: HMDB01514
initial amount: NaN
constant: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_0bcfffa8_1ba0_4278_b387_c76161411ae3
type: Species
is encoded by: hsa:2356
initial amount: NaN
initial concentration: NaN
is: Q05932
is: SBO:0000252
boundary condition: true
name: FPGS
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_86de4f23_5c2f_4eff_b1d0_14507b134c1f
constant: false
name: PIGH
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5283
boundary condition: true
is: Q14442

http://identifiers.org/biomodels.db/MODEL1310110048#_e6df756d_be90_4e5d_b276_2ec9f53ed70a
is: Q9HC58
initial concentration: NaN
is encoded by: hsa:57419
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: SLC24A3

metaM CE2435 m
has only substance units: false
boundary condition: false
is: CHEBI:57795
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial amount: NaN
name: trans,cis-deca-2,4-dienoyl-CoA
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR GTHPm
name: glutathione peroxidase, mitochondria
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.11.1.12
is: SBO:0000176
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is described by: ECO:0000269
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.15
reversible: true
fast: false

metaR GLUTCOADHm
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
name: glutaryl-CoA dehydrogenase (mitochondria)
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.99.7
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
is described by: ECO:0000304
modifier: MODEL1310110048#
fast: false
reversible: false

metaR NICRNS
kinetic law: MODEL1310110048#
name: NICRNS
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
fast: false
reversible: false

metaR RE3074X
type: Reaction
modifier: MODEL1310110048#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3074
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
fast: false
reactant: MODEL1310110048#

metaM ksi pre6 g
constant: false
is: C00130
initial amount: NaN
notes: FORMULA: C107H174N7O80SX CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 6
has only substance units: false
is: HMDB00175
is: CHEBI:58053

metaR MI14P4P
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000176
fast: false
name: inositol-1,4-bisphosphate 4-phosphatase
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

metaR MALTSULtm
reactant: MODEL1310110048#
reversible: true
is: SBO:0000185
name: Malate:thiosulfate antiport, mitochondrial
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110048#

metaM ksii core4 pre3 g
is: CHEBI:58053
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 3
boundary condition: false
constant: false
is: C00130
is: HMDB00175
has only substance units: false
type: Species
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: SBO:0000247

metaM 6dhf e
boundary condition: false
is: SBO:0000247
name: hexaglutamyl folate (DHF)
initial amount: NaN
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
has only substance units: false
type: Species
constant: false
is: HMDB06563
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_99507958_2b22_4529_8a5d_b17c11a06af3
is: SBO:0000252
name: PKM2
initial amount: NaN
boundary condition: true
is encoded by: hsa:5315
is: P14618
initial concentration: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_7bc34c56_165f_40c6_b06a_9773a0e9f8d4
type: Species
name: AGXT2L1
has only substance units: false
is encoded by: hsa:64850
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q8TBG4
constant: false

metaM ditp c
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:61382
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: HMDB03537
name: dITP(4-)

http://identifiers.org/biomodels.db/MODEL1310110048#_db014111_6fa5_4690_9401_b88bd91336be
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1103
has only substance units: false
is: Q6LEN5
name: CHAT
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR FE2t
type: Reaction
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
kinetic law: MODEL1310110048#
is: SBO:0000185
name: iron (II) transport
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: false

metaM c226coa x
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
is: SBO:0000247
constant: false
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
type: Species
boundary condition: false
is: C16169
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_653fec70_d64d_444a_b9b9_725db5cbc014
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: RRM2B
is encoded by: hsa:50484
is: Q7LG56
has only substance units: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM lnlccoa r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01064
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A

metaM na1 r
constant: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial concentration: 1.0
has only substance units: false
name: sodium(1+)
is: CHEBI:29101
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00588
type: Species

metaR FUMm
is: SBO:0000176
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
is described by: ECO:0000134
name: fumarase, mitochondrial
modifier: MODEL1310110048#
reversible: true
fast: false
product: MODEL1310110048#

metaM glyc c
is: C00116
type: Species
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
initial amount: NaN
is: HMDB00131
initial concentration: 1.0
name: Glycerol
has only substance units: false
is: SBO:0000247
is: CHEBI:17754

metaM thbpt4acam c
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02281
type: Species
is: CHEBI:15374
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 4a-hydroxytetrahydrobiopterin

metaR BMTer L
fast: false
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
type: Reaction
product: MODEL1310110048#
name: B mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110048#
is: SBO:0000176
reversible: false
modifier: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#

metaR H2Otly
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
reversible: true
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000

metaR FAS160COA
name: fatty-acyl-CoA synthase (n-C16:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
type: Reaction

metaR DNDPt28m
reversible: false
reactant: MODEL1310110048#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
name: dCDP transport via dGDP antiport

http://identifiers.org/biomodels.db/MODEL1310110048#_bfc56d7d_d2af_42f2_bc35_efd6861cd5ce
is encoded by: hsa:128869
has part: O43292
name: PIGK:PIGU:PIGT:GPAA1:PIGS
has part: Q9H490
is encoded by: hsa:10026
is encoded by: hsa:51604
has part: Q8NBL9
is encoded by: hsa:94005
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000297
has part: Q969N2
is encoded by: hsa:8733
initial concentration: NaN
boundary condition: true
has part: Q92643

metaR DTMPK
is described by: ECO:0000269
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: dTMP kinase
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.9

metaM CE2433 m
type: Species
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57795
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
has only substance units: false

metaM glyc3p c
is: HMDB00126
boundary condition: false
is: SBO:0000247
constant: false
is: C00093
initial amount: NaN
is: CHEBI:57597
has only substance units: false
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_c9187160_2383_47c6_a8dd_4ddb635ec1d1
name: NDUFA1
has only substance units: false
is encoded by: hsa:4694
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is: Q6IBB5
boundary condition: true
type: Species

metaM dmpp x
is: HMDB01120
name: prenyl diphosphate(3-)
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57623
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: SBO:0000247
initial amount: NaN

metaM bilirub e
name: bilirubin(2-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
is: HMDB00054
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_62795e75_7668_42c6_a554_cfd0869c5041
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5730
is: P41222
constant: false
initial amount: NaN
name: PTGDS
initial concentration: NaN
type: Species

metaM HC02121 c
initial concentration: 1.0
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
type: Species
boundary condition: false
is: CHEBI:58758
is: SBO:0000247
has only substance units: false
constant: false

metaR r1866
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
type: Reaction

metaM gdpfuc g
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01095
name: GDP-L-fucose(2-)
is: CHEBI:57984

http://identifiers.org/biomodels.db/MODEL1310110048#_a89230f5_54da_44ba_b42c_f85b138710ab
is: SBO:0000252
has only substance units: false
name: SLC12A7
is encoded by: hsa:10723
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: Q9Y666

http://identifiers.org/biomodels.db/MODEL1310110048#_90d6494d_3659_4a5f_bec6_a6f4e1ce6c62
is encoded by: hsa:55907
is: Q8NFW8
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: CMAS

http://identifiers.org/biomodels.db/MODEL1310110048#_e29e3b15_6b6d_49f9_9272_5aa8fc05a859
name: COX7B2
constant: false
is encoded by: hsa:170712
has only substance units: false
initial concentration: NaN
is: Q8TF08
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaR r1992
is: SBO:0000185
modifier: MODEL1310110048#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR RE3567C
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#
name: RE3567
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false

metaR r1640
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#

metaM hom L c
type: Species
is: CHEBI:15699
constant: false
is: HMDB00719
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: L-homoserine
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d91c4a62_de5d_4d56_8ac1_9101dc5f1787
is encoded by: hsa:5315
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: PKM2
type: Species
initial concentration: NaN
is: P14618
is: SBO:0000252

metaR RETI2
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: retinol isomerase (9-cis)
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaM 3hpcoa m
initial concentration: 1.0
type: Species
has only substance units: false
name: 3-hydroxypropanoyl-CoA(4-)
is: CHEBI:58528
constant: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB06807

http://identifiers.org/biomodels.db/MODEL1310110048#_e9097345_f1fb_4bdc_b5bb_3e27c6ec8258
is: SBO:0000252
constant: false
is encoded by: hsa:7498
boundary condition: true
has only substance units: false
is: P47989
initial concentration: NaN
type: Species
initial amount: NaN
name: XDH

http://identifiers.org/biomodels.db/MODEL1310110048#_96e67649_d0be_49a9_9790_954ed52c1eed
name: B3GNT2
is: SBO:0000252
is encoded by: hsa:10678
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: Q9NY97
initial amount: NaN

metaM gsn c
name: Guanosine
constant: false
has only substance units: false
is: C00387
is: CHEBI:16750
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_0e854588_1847_4ca7_b822_d0cc5d559c31
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: GGT1
is encoded by: hsa:2678
constant: false
initial amount: NaN
has only substance units: false

metaM hmgcoa m
is: CHEBI:15467
has only substance units: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
constant: false
initial amount: NaN
is: HMDB01375
boundary condition: false
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_2bdff666_a8dc_4e5d_b1a5_28485432eba7
is: SBO:0000252
is encoded by: hsa:123041
boundary condition: true
constant: false
initial amount: NaN
name: SLC24A4
type: Species
initial concentration: NaN
has only substance units: false

metaR NACHEX27ly
modifier: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reversible: false
kinetic law: MODEL1310110048#
name: beta-N-acetylhexosaminidase, lysosomal

metaR G14T14g
kinetic law: MODEL1310110048#
reversible: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110048#

metaM pro L c
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB00162
name: L-proline
initial concentration: 1.0

metaR ADRNCOAtx
name: fatty acid intracellular transport
type: Reaction
reversible: true
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM 3oddcoa m
is: CHEBI:27868
boundary condition: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
name: 3-Oxododecanoyl-CoA
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB03937
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_db6312b7_5aa8_4cd3_870f_277dedf576c3
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5106
has only substance units: false
is: Q16822
boundary condition: true
type: Species
is: SBO:0000252
name: PCK2

http://identifiers.org/biomodels.db/MODEL1310110048#_f7fee1fb_5353_486f_be67_11b0608a1306
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI601100
constant: false
initial amount: NaN
type: Species
name: _AI601100_1_m
boundary condition: true

metaM glyc e
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00131
is: C00116
is: CHEBI:17754
name: Glycerol
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
type: Species

metaR RE2974C
is version of: http://identifiers.org/ec-code/2.7.1.68
modifier: MODEL1310110048#
name: RE2974
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.149
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR CORE2GTg
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.102
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
type: Reaction
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110048#
fast: false
is: SBO:0000176

metaR GLYC3Ptmc
fast: false
name: glycerol-3-phopshate transport, cytoplasm
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.

metaR KCCt
name: K+-Cl- cotransport
reversible: true
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ee79a5bd_8ec5_4325_9dac_2f70fc31a3dc
type: Species
constant: false
has only substance units: false
name: _AA278423_1_m
is: SBO:0000252
is encoded by: hsa:AA278423
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_260e40c2_6986_4cdb_a0c6_18411852e267
is encoded by: hsa:2530
constant: false
is: G3V5N0
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: FUT8
is: SBO:0000252

metaR LGNCt
is: SBO:0000185
reactant: MODEL1310110048#
reversible: true
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110048#_a77c0e8d_56f2_43dd_bd46_2ead45aa71c1
is: B4DKS0
is encoded by: hsa:6566
has only substance units: false
initial concentration: NaN
name: SLC16A1
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b43493e4_0f12_4ee8_bca3_8ef73cb85be6
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:NOS2A
has only substance units: false
name: _NOS2A_1_e
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_dcd390c3_130a_4340_9488_3de109740756
is encoded by: hsa:3948
is: SBO:0000252
has only substance units: false
name: LDHC
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaM mn l
type: Species
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB06535
initial concentration: 1.0
name: beta-1,4-mannose-N-acetylglucosamine

http://identifiers.org/biomodels.db/MODEL1310110048#_aee5da7c_c36a_4d48_afe7_e89daf1eafc4
initial concentration: NaN
name: DLAT
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1737
initial amount: NaN
is: Q86YI5
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_0f7ef1de_f734_4cec_ade2_544ee03b4098
name: SLC13A4
is: Q9UKG4
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:26266
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r0549
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.6.5.3
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.1.1.17
is: SBO:0000176
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:

metaR r2386
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
kinetic law: MODEL1310110048#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110048#

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM hedepecoa m
initial concentration: 1.0
boundary condition: false
is: HMDB02288
constant: false
name: 2,4,7,10,13-hexadecapentenoylcoa
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_d2a96a94_4cfa_49b3_9b92_d6df62268dd5
is: B4DK61
type: Species
initial concentration: NaN
is encoded by: hsa:51
has only substance units: false
is: SBO:0000252
name: ACOX1
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_469a513d_0a16_489d_a744_e17e569757e8
initial concentration: NaN
name: PGM1
is: B4DPV0
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:5236
has only substance units: false
is: SBO:0000252
type: Species

metaR RE1525M
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
modifier: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE1525
kinetic law: MODEL1310110048#
type: Reaction

metaR UGT1A2r
product: MODEL1310110048#
fast: false
is: SBO:0000176
reactant: MODEL1310110048#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54575.1) or (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:15117964,PMID:9295054 NOTES:NJ
type: Reaction
reversible: false
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_deb05a1d_cb65_422d_bb56_c6df3584650a
has only substance units: false
has part: P19404
has part: O95168
is encoded by: hsa:4707
has part: O75251
is encoded by: hsa:4720
is encoded by: hsa:374291
initial amount: NaN
has part: O00217
is encoded by: hsa:4708
constant: false
has part: Q13454
has part: F8VQS7
is encoded by: hsa:4697
is encoded by: hsa:4705
is encoded by: hsa:4701
has part: Q16718
has part: O00483
has part: Q6FG42
has part: P56181
is: SBO:0000297
has part: Q9P0J0
is encoded by: hsa:4728
is encoded by: hsa:4724
has part: Q7GXZ1
has part: Q7GXY9
is encoded by: hsa:4709
is encoded by: hsa:4537
has part: Q85KV6
is encoded by: hsa:4722
initial concentration: NaN
boundary condition: true
has part: P56556
has part: Q7GXZ4
has part: O43678
is encoded by: hsa:51079
is encoded by: hsa:4535
has part: P28331
has part: O75438
is encoded by: hsa:4694
is encoded by: hsa:4717
has part: Q6IBC4
is encoded by: hsa:4713
has part: P03915
has part: P03897
is encoded by: hsa:4540
is encoded by: hsa:7991
has part: O43677
has part: O14561
has part: C9JT23
has part: A8K761
has part: O95167
is encoded by: hsa:4729
is encoded by: hsa:55967
is encoded by: hsa:4725
has part: O43181
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q9Y6M9
is encoded by: hsa:4715
is encoded by: hsa:4711
is encoded by: hsa:4726
has part: E5KNH5
is encoded by: hsa:4723
is encoded by: hsa:4710
is encoded by: hsa:4539
has part: O75489
has part: O95139
is encoded by: hsa:4698
is encoded by: hsa:4538
has part: P03905
has part: O95169
has part: P17568
has part: Q6IB80
has part: Q16795
is encoded by: hsa:4731
is encoded by: hsa:4696
is encoded by: hsa:4719
has part: O43674
is encoded by: hsa:4536
is encoded by: hsa:4706

metaM q10 e
constant: false
is: CHEBI:46245
is: SBO:0000247
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
is: HMDB01072
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_c27fc7b6_d248_44a2_b49f_dc28fd4f1fcf
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8781
constant: false
name: _8781_1_c
initial concentration: NaN
type: Species
boundary condition: true

metaM nad x
is: CHEBI:57540
type: Species
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
initial amount: NaN
is: HMDB00902
is: C00003
has only substance units: false
initial concentration: 1.0

metaM pail35p hs c
type: Species
boundary condition: false
constant: false
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
has only substance units: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)

metaM ppi e
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
is: CHEBI:33019
name: Diphosphate
type: Species
is: C00013
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110048#_b3fcc0c1_c455_4e13_a27e_3a6079ab08a2
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4709
name: NDUFB3
has only substance units: false
type: Species
initial concentration: NaN
is: Q6IB80

metaR r1380
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:

metaR COAtp
reversible: true
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: coenzyme A transport, peroxisomal
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_96724339_7c13_472e_9de4_a79ea5fa89ca
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: P51857
name: AKR1D1
initial concentration: NaN
is encoded by: hsa:6718
boundary condition: true
is: SBO:0000252

metaR r0149
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110048#_d3acdf55_51b5_47ae_a0d8_3772e356cea7
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: LYZL1
is encoded by: hsa:84569
is: SBO:0000252
is: Q6UWQ5

metaR GPIMTer L
is described by: ECO:0000000
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
fast: false
reversible: false
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#

metaM hmgcoa c
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
has only substance units: false
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
type: Species
is: HMDB01375
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_e3fafba2_6df9_46a1_8608_180850381104
is encoded by: hsa:5723
initial amount: NaN
type: Species
constant: false
is: P78330
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PSPH
initial concentration: NaN

metaR r2387
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#

metaR FALDH
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
name: formaldehyde dehydrogenase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110048#

metaM udpacgal c
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00304
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
is: SBO:0000247
is: CHEBI:57847
initial concentration: 1.0

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM mescon m
is: CHEBI:36986
constant: false
initial amount: NaN
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
boundary condition: false
type: Species
is: HMDB00749
is: SBO:0000247
has only substance units: false
name: Mesaconate
initial concentration: 1.0

metaR CO2t
is described by: ECO:0000000
name: CO2 transporter via diffusion
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_0749440d_ad3e_407e_ade1_c22f31707b5d
boundary condition: true
type: Species
constant: false
name: DGKZ
is: SBO:0000252
is: B7Z2M9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8525
has only substance units: false

metaM cholcoads x
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: HMDB06889
is: CHEBI:27505
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
boundary condition: false

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR SERTHRNaEx
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110048#

metaR NDP7g
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
name: nucleoside-diphosphatase (UDP), Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110048#_b66540cb_81cb_4dc7_b5b7_73d2a0658faa
boundary condition: true
type: Species
name: ST3GAL3
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6487

metaM urea e
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
type: Species
is: C00086
name: Urea
is: HMDB00294
has only substance units: false
initial concentration: 1.0
is: CHEBI:16199

metaR FAOXC101C8m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM retinal 11 cis c
initial amount: NaN
name: 11-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
initial concentration: 1.0
is: HMDB02152
is: SBO:0000247
is: CHEBI:16066
constant: false
has only substance units: false
boundary condition: false

metaM cbasp e
is: HMDB00828
type: Species
name: N-Carbamoyl-L-aspartate
is: C00438
boundary condition: false
constant: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
has only substance units: false
is: SBO:0000247
is: CHEBI:32814
initial amount: NaN
initial concentration: 1.0

metaM dec47dicoa m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 4,7-decadienoylcoa

metaR RE3624M
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3624
reversible: false
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR r1381
reversible: true
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000176
reactant: MODEL1310110048#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5

metaR AMPtp
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000
name: AMP transporter, peroxisome
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ

metaR r0331
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
kinetic law: MODEL1310110048#

metaR VALt5m
fast: false
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Valine reversible mitochondrial transport
is described by: ECO:0000000
type: Reaction

metaM ksii core2 pre2 g
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 2
initial concentration: 1.0
is: C00130
is: HMDB00175
constant: false
has only substance units: false
notes: FORMULA: C39H63N3O28X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110048#_3df2f40d_d8b4_4095_ad81_26e9c7d9549d
initial amount: NaN
boundary condition: true
type: Species
name: _M68895_1_c
is: SBO:0000252
is encoded by: hsa:M68895
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_f35c4093_232f_4535_86ea_4a663deb849e
is encoded by: hsa:5305
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PIP4K2A
has only substance units: false
is: SBO:0000252
is: P48426

metaR RE0453C
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
name: RE0453
product: MODEL1310110048#

metaR r2388
modifier: MODEL1310110048#
reversible: false
fast: false
reactant: MODEL1310110048#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM oaa x
initial amount: NaN
is: HMDB00223
has only substance units: false
constant: false
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
name: Oxaloacetate
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16452
boundary condition: false

metaM tdcoa m
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: C02593
type: Species
is: HMDB01521
initial concentration: 1.0
constant: false
is: CHEBI:57385
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d23ecbc4_2a90_4c4b_8e5c_1b0f4a045dd8
is encoded by: hsa:AA081045
constant: false
name: _AA081045_1_e
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaM 6dhf m
constant: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false
type: Species
is: HMDB06563
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_34153238_62b3_49e0_8764_b62ed3c302d2
has only substance units: false
name: SLC25A16
boundary condition: true
is: SBO:0000252
constant: false
is: P16260
type: Species
is encoded by: hsa:8034
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_d19cc808_ec04_4469_ae81_663e9f9cf68c
type: Species
has only substance units: false
is encoded by: hsa:AL048840
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _AL048840_1_c
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_eff43a12_8e47_44a0_9f03_0420782965a9
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: P49448
type: Species
name: GLUD2
is encoded by: hsa:2747
has only substance units: false
is: SBO:0000252

metaM lnlnca r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:32387
is: SBO:0000247
is: HMDB01388
initial amount: NaN
type: Species
name: alpha-linolenate

http://identifiers.org/biomodels.db/MODEL1310110048#_2d7b6641_3fb4_4e74_b2dc_3886d5882e32
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4726
is: Q6IBC4
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: NDUFS6

metaR ALADGLYexR
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000304
reactant: MODEL1310110048#
reversible: true
name: D-alanine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110048#

metaR COAtn
name: coenzyme A transport, nuclear
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_d552f67c_41d3_4b9e_8a89_8e29dde0d524
type: Species
is: Q13057
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:80347
name: COASY
initial amount: NaN
constant: false

metaM HC01407 m
type: Species
has only substance units: false
name: (S)-Hydroxyhexanoyl-CoA
initial amount: NaN
is: CHEBI:28276
boundary condition: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_82bc7ccc_c159_4435_912d_9e52ca71f7b5
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4712
is: Q5VYT2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: NDUFB6

metaR PEROXx
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: false
name: peroxisomal lumped long chain fatty acid oxidation
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ

metaM xylt c
initial concentration: 1.0
is: CHEBI:17151
is: HMDB02917
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol
has only substance units: false
constant: false

metaM tre e
is: C01083
boundary condition: false
constant: false
has only substance units: false
is: HMDB00975
is: CHEBI:16551
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Trehalose

metaM 4izp c
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
boundary condition: false
is: HMDB01014
is: CHEBI:57255
name: 4-Imidazolone-5-propanoate
initial concentration: 1.0

metaR r1454
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false

metaM HC02202 e
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
initial concentration: 1.0
name: prostaglandin A1(1-)
boundary condition: false

metaR r0545
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110048#

metaM udpacgal g
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
has only substance units: false
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM Ser Thr l
is: HMDB01342
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
initial amount: NaN
type: Species
is: CHEBI:37568
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
is: C00459
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r1867
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110048#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#

metaR GLUt7l
reactant: MODEL1310110048#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
name: Glutamate transport, lysosomal
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR r2389
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR MM6bg
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.113
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_33cda844_f95a_4021_8dc0_db6f78031ca1
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: CHST2
has only substance units: false
is encoded by: hsa:9435
boundary condition: true
is: Q9Y4C5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_99d3ddad_927d_4748_b4d8_714d38943b3f
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:389015
is: Q6AI14
boundary condition: true
name: SLC9A4
initial amount: NaN

metaM ppi c
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
is: C00013
is: CHEBI:0
boundary condition: false
name: Diphosphate
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM 6dhf l
name: hexaglutamyl folate (DHF)
type: Species
is: HMDB06563
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_944b99e4_8597_4dd9_95db_56e84bd7973d
boundary condition: true
is: SBO:0000252
is encoded by: hsa:92745
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: Q8WUX1
name: SLC38A5
initial amount: NaN

metaR COAtm
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
type: Reaction
fast: false
reversible: true
name: CoA transporter
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
is described by: ECO:0000269
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_914f1a8d_35e6_425b_bbf8_5e18d99bf3ff
is encoded by: hsa:29920
is: Q96C36
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: PYCR2

http://identifiers.org/biomodels.db/MODEL1310110048#_df616027_3483_453f_a608_e3297e087b92
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:124
is: SBO:0000252
initial amount: NaN
constant: false
name: ADH1A
is: P07327
boundary condition: true

metaM urea c
is: CHEBI:16199
boundary condition: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial amount: NaN
constant: false
is: SBO:0000247
name: Urea
type: Species
is: C00086
is: HMDB00294
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_63661d0c_3134_48d6_ae3e_8a40df754812
is encoded by: hsa:115019
name: SLC26A9
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q7LBE3

metaM amp x
is: CHEBI:456215
initial amount: NaN
name: AMP
is: C00020
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM dolglcp U r
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
is: CHEBI:15812
constant: false
initial amount: NaN
is: SBO:0000247

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM HC01405 m
is: CHEBI:28632
constant: false
type: Species
boundary condition: false
has only substance units: false
name: (S)-Hydroxyoctanoyl-CoA
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r1453
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
product: MODEL1310110048#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reversible: true
fast: false

metaM pmtcoa m
is: CHEBI:57379
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
boundary condition: false
has only substance units: false
is: HMDB01338
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM gam e
boundary condition: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: HMDB01514
type: Species
initial concentration: 1.0
is: CHEBI:17315
name: D-Glucosamine
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: C00329

metaM 3aib D c
initial amount: NaN
type: Species
is: HMDB02299
is: SBO:0000247
initial concentration: 1.0
name: D-3-Amino-isobutanoate
is: C03265
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715

metaR RE3270C
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
fast: false
reversible: true
name: RE3270
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaM uacgam c
type: Species
constant: false
is: SBO:0000247
is: HMDB00290
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN
is: CHEBI:57705

http://identifiers.org/biomodels.db/MODEL1310110048#_660c0e67_899d_417e_9fc6_cbab178c7e84
initial amount: NaN
constant: false
type: Species
name: GCSH
is encoded by: hsa:2653
is: SBO:0000252
has only substance units: false
is: P23434
boundary condition: true
initial concentration: NaN

metaR RDH3a
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (11-cis,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.300
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110048#

metaM 3mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
is: HMDB01493
is: CHEBI:57344

metaM HC02202 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:57398
name: prostaglandin A1(1-)

metaR r0145
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.8.3.1
is: SBO:0000176
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39

metaR r1456
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
name: Transport reaction
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_c44668e0_56b9_4497_b480_6eb90d483508
is: P09417
type: Species
initial amount: NaN
name: QDPR
is encoded by: hsa:5860
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r1434
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Transport reaction
reversible: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR LNLCCRNt
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
name: transport into the mitochondria (carnitine)
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110048#

metaR MECOAS1m
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000304
product: MODEL1310110048#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
modifier: MODEL1310110048#

metaR PLA2 2e
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
is version of: http://identifiers.org/ec-code/3.1.1.4
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110048#
name: phospholipase A2
reversible: false
reactant: MODEL1310110048#

metaM gam6p c
is: CHEBI:12962
type: Species
has only substance units: false
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: HMDB01254
boundary condition: false
initial concentration: 1.0
name: D-Glucosamine 6-phosphate
constant: false
is: SBO:0000247
initial amount: NaN

metaR DCSPTN1CRNt
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110048#
fast: false
type: Reaction
reversible: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM gua e
is: SBO:0000247
has only substance units: false
name: guanine
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: CHEBI:16235
is: HMDB00132

http://identifiers.org/biomodels.db/MODEL1310110048#_c3a8113b_90d9_4179_9fa5_077118a67cb5
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7001
name: PRDX2
type: Species
initial concentration: NaN

metaR ACCOAC
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_65cf1639_de93_4d46_9fae_bd3dafa0af2a
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9HBH5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:57665
name: RDH14
constant: false
type: Species

metaM HC01104 e
name: 4-nitrophenyl phosphate(2-)
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61146
type: Species
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360

http://identifiers.org/biomodels.db/MODEL1310110048#_6956fe84_51d7_43e6_baf8_fa8daa8b44a5
type: Species
boundary condition: true
name: LHPP
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:64077
constant: false
is: Q9H008

http://identifiers.org/biomodels.db/MODEL1310110048#_1caf2f6b_19ec_4aca_a27d_c069db383129
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4698
name: NDUFA5
has only substance units: false
is: Q16718
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM 3hexdtricoa m
initial concentration: 1.0
name: 3,7,10-hexadecatrienoylcoa
initial amount: NaN
constant: false
is: HMDB02288
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_44e73c02_b33a_4fb7_8e20_b03c29bdaa61
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:AF080579
has only substance units: false
constant: false
initial concentration: NaN
name: _AF080579_1_c
boundary condition: true

metaR LEUGLYHYc
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: hydrolysis of leucylglycine
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
fast: false
is: SBO:0000176
reversible: true

metaR GAMYe
type: Reaction
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.3 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:NCD
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
name: glucoamylase, extracellular (glygn5 -> malt)
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.20
product: MODEL1310110048#

metaR NDP7er
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
is described by: ECO:0000000

metaM amp r
initial concentration: 1.0
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
name: AMP
is: SBO:0000247
type: Species
is: C00020
is: HMDB00045
has only substance units: false
initial amount: NaN
boundary condition: false

metaR r1455
fast: false
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_b93e8acf_0cc0_48c0_824f_6e4940aa22c6
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000297
constant: false
is encoded by: hsa:4830
name: NME1:NME2
initial concentration: NaN
type: Species

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_1d8adf1f_be3a_4c6b_9ae4_67ad44b2ae1c
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:7296
name: TXNRD1
has only substance units: false

metaR AATAi
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
is: SBO:0000176
name: 2-aminoadipate transaminase, irreversible
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
modifier: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.6.1.7

metaM i c
name: iodide
boundary condition: false
is: CHEBI:16382
is: HMDB12238
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
constant: false

metaM mmcoa S m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB02310
is: SBO:0000247
boundary condition: false
is: CHEBI:57327
type: Species
name: (S)-methylmalonyl-CoA(5-)
initial amount: NaN

metaR GUAPRT
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000269
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: guanine phosphoribosyltransferase

metaM idp e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58280
constant: false
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaM core4 g
type: Species
is: CHEBI:16478
initial amount: NaN
is: SBO:0000247
name: Core 4
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H40N3O15X CHARGE: 0
constant: false

metaM udpglcur r
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: UDP-D-glucuronate
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
has only substance units: false
is: HMDB00935

metaM C02528 r
initial concentration: 1.0
boundary condition: false
name: chenodeoxycholate
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN
has only substance units: false
is: CHEBI:36234
is: SBO:0000247
is: HMDB00518
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8fe7f41b_0d53_49c8_a77e_ab46e4a81756
name: SUCLG1:SUCLA2
has only substance units: false
is: SBO:0000297
has part: E5KS60
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8803
constant: false
type: Species
initial amount: NaN

metaM q10 c
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
name: ubiquinone-10
is: HMDB01072
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:46245
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR LDH L
reversible: true
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110048#
name: L-lactate dehydrogenase
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110048#

metaM HC00695 m
name: S-Succinyldihydrolipoamide
has only substance units: false
constant: false
is: CHEBI:17432
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR FAOXOHMC10DC10c
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHMC10-->DC10)c
type: Reaction

metaR HMGCOAtm
product: MODEL1310110048#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
type: Reaction

metaR r0541
reactant: MODEL1310110048#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110048#

metaR BAMPPALDOX
is described by: ECO:0000212
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
kinetic law: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110048#

metaM fmn e
boundary condition: false
is: CHEBI:58210
type: Species
initial amount: NaN
is: HMDB01520
is: C00061
has only substance units: false
initial concentration: 1.0
name: FMN
is: SBO:0000247
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110048#_35e95f9b_d3a3_47f8_ac09_507bc6b75eef
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:771
name: CA12
type: Species
is: SBO:0000252
initial amount: NaN

metaM atp x
is: CHEBI:57299
type: Species
is: SBO:0000247
is: C00002
boundary condition: false
constant: false
name: ATP(4-)
is: HMDB00538
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM hdd2coa x
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: (E)-hexadec-2-enoyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
is: CHEBI:61526
is: HMDB03945
boundary condition: false

metaM creat e
name: creatine
boundary condition: false
is: SBO:0000247
is: HMDB00064
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
is: CHEBI:16919
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_214dba86_819e_4fc6_b9fc_c08ff72a57f0
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:8527
initial concentration: NaN
constant: false
has only substance units: false
name: DGKD

metaR PPItx
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
name: Diphosphate transporter, peroxisome
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM creat c
is: HMDB00064
is: SBO:0000247
is: CHEBI:16919
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: creatine
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_9072643e_d1da_44c3_9379_31bfda9d2d97
type: Species
initial concentration: NaN
is: O43451
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8972
constant: false
name: MGAM

http://identifiers.org/biomodels.db/MODEL1310110048#_513da7a5_0bef_45d4_8f55_940b419ac82c
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: DPM2
is encoded by: hsa:8818
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR GGH 7THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110048#
name: Gamma-glutamyl hydrolase (7THF), extracellular

http://identifiers.org/biomodels.db/MODEL1310110048#_aff89b2d_f4d0_4836_a17e_e66c6fc304fd
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PNPO
is: Q9NVS9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55163
constant: false

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
name: beta-galactosidase, lysosomal
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#

metaM gua c
is: C00242
is: HMDB00132
has only substance units: false
is: SBO:0000247
name: Guanine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
constant: false
type: Species
is: CHEBI:16235

metaM gpi prot hs r
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
initial concentration: 1.0
is: C00249
is: CHEBI:7896
is: SBO:0000247
boundary condition: false
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
is: HMDB00220
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR PNTK
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: false
is described by: ECO:0000269
product: MODEL1310110048#
name: pantothenate kinase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_cd614cd9_a295_4308_a648_20f7c00c0149
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:2679
type: Species
initial concentration: NaN
boundary condition: true
name: GGT3P
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_27ee153e_f2df_4998_adcf_bc564f507400
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51703
boundary condition: true
initial concentration: NaN
type: Species
is: Q9ULC5
initial amount: NaN
name: ACSL5

metaM hx2coa m
name: trans-Hex-2-enoyl-CoA
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
has only substance units: false

metaM HC01115 c
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: NeuNGc
is: CHEBI:29025
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410

metaR ACt2m
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
name: acetate mitochondrial transport via proton symport
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD

metaR BUTt2r
is: SBO:0000185
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
type: Reaction
name: Butyrate transport via proton symport, reversible
product: MODEL1310110048#
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110048#

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial amount: NaN
boundary condition: false
name: N-Carbamoyl-L-aspartate
is: C00438
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00828
is: CHEBI:32814

http://identifiers.org/biomodels.db/MODEL1310110048#_fbfdf97b_a69a_4391_87d5_427e7448263a
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: HAS3
is encoded by: hsa:3038
is: O00219
initial amount: NaN

metaM n2m2masn g
has only substance units: false
is: C11530
notes: FORMULA: C50H83N4O35X CHARGE: 0
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

metaM ksii core2 pre5 g
has only substance units: false
is: CHEBI:58053
initial amount: NaN
is: C00130
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false
is: HMDB00175
constant: false
type: Species
name: keratan sulfate II biosynthesis, precursor 5

metaM ctp c
is: CHEBI:37563
has only substance units: false
type: Species
initial amount: NaN
name: CTP
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00082
is: C00063
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_7c219e76_477b_483c_99d3_5a72859eb982
is: P07686
boundary condition: true
type: Species
is encoded by: hsa:3074
name: HEXB
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR r0081
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110048#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110048#_212000f5_bc0d_4aa4_a231_bea45deb20d0
is encoded by: hsa:54344
is: SBO:0000252
initial amount: NaN
name: DPM3
type: Species
constant: false
boundary condition: true
is: Q9P2X0
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_549cb21c_64e1_45b3_a5ea_f51f5e3ab8f2
is: P48736
boundary condition: true
is encoded by: hsa:5294
name: PIK3CG
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaM amp m
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00045
initial concentration: 1.0
type: Species
name: AMP(2-)
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215

metaR DHFtl
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000185
name: dihydrofolate reversible lysosomal transport
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
reversible: true
fast: false
reactant: MODEL1310110048#

metaM ttdca e
name: tetradecanoate (n-C14:0)
boundary condition: false
is: HMDB00806
constant: false
is: C06424
is: CHEBI:30807
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_58896331_b2f7_45bc_8ae3_bad61a90f69d
initial concentration: NaN
constant: false
name: ACSL4
type: Species
is: Q5JWV8
is encoded by: hsa:2182
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r0483
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#
fast: false
is: SBO:0000176
reactant: MODEL1310110048#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22

metaM g1m8mpdol U r
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
has only substance units: false
initial amount: NaN
is: CHEBI:59093
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
boundary condition: false

metaM dece4coa m
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB02145
name: 4-decenoylcoa
boundary condition: false
initial amount: NaN

metaM uacgam g
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00290
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: CHEBI:57705
initial concentration: 1.0

metaM ppi m
is: SBO:0000247
is: HMDB00250
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
name: Diphosphate
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C00013
is: CHEBI:33019

metaM bilirub r
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00054
is: CHEBI:57977
has only substance units: false
name: bilirubin(2-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaR PI34P5K
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110048#
fast: false
type: Reaction
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reversible: false
is: SBO:0000176

metaM pro D c
type: Species
is: HMDB03411
boundary condition: false
initial amount: NaN
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:16313

metaR r1649
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM pan4p c
name: Pantetheine 4'-phosphate
constant: false
is: HMDB01416
is: SBO:0000247
type: Species
is: CHEBI:47942
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM ksii core2 pre8 g
is: C00130
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 8
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110048#_519282b9_d19f_481b_ae17_fc44d25ba5e1
is encoded by: hsa:9488
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: PIGB
initial amount: NaN
is: SBO:0000252
is: Q92521

metaM tdchola e
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:9407
name: taurochenodeoxycholate
initial concentration: 1.0
initial amount: NaN
is: HMDB00951
constant: false
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

metaM glc D e
type: Species
is: HMDB00122
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
constant: false
initial concentration: 1.0
name: D-glucose

http://identifiers.org/biomodels.db/MODEL1310110048#_1df7f035_f43f_496b_9669_ec533bee7b6f
is encoded by: hsa:2588
initial concentration: NaN
is: P34059
is: SBO:0000252
name: GALNS
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false

metaM idp c
is: SBO:0000247
type: Species
is: CHEBI:58280
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
initial amount: NaN
is: HMDB03335
initial concentration: 1.0
has only substance units: false
name: IDP(3-)

metaM Tyr ggn e
is: HMDB01452
constant: false
initial concentration: 1.0
is: CHEBI:57445
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: XOH CHARGE: 0
initial amount: NaN

metaR RE2974N
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is: SBO:0000176
product: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000000
name: RE2974
type: Reaction

metaM lnlnca l
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:32387
boundary condition: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: HMDB01388
initial amount: NaN
is: SBO:0000247
name: alpha-linolenate

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR SO4OXAtex2
is: SBO:0000185
kinetic law: MODEL1310110048#
fast: false
type: Reaction
reversible: false
name: sulfate transport via oxalate countertransport (2:1)
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304

metaR PHYHx
is described by: ECO:0000269
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.14.11.18
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
kinetic law: MODEL1310110048#
name: Phytanoyl-CoA dioxygenase, peroxisomal

metaR RE0453N
product: MODEL1310110048#
reactant: MODEL1310110048#
name: RE0453
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR KSII CORE4tly
reactant: MODEL1310110048#
reversible: false
is described by: ECO:0000000
product: MODEL1310110048#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110048#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaM cyan e
constant: false
is: CHEBI:18407
type: Species
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR DHCR242r
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110048#
reversible: false
name: 24-dehydrocholesterol reductase [Precursor]
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_27c7cb34_74cb_4356_8d9c_7cb67e951d28
boundary condition: true
initial amount: NaN
is: P42765
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:10449
is: SBO:0000252
has only substance units: false
name: ACAA2

http://identifiers.org/biomodels.db/MODEL1310110048#_81fa952f_1e90_4267_836d_2e38683d282b
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: MTMR6
has only substance units: false
initial concentration: NaN
is: Q9Y217
is encoded by: hsa:9107
is: SBO:0000252

metaM CE5119 m
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57923
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: trans-3-cis-8-tetradecadienoyl-CoA

metaM glyald c
boundary condition: false
constant: false
is: HMDB01051
is: SBO:0000247
name: D-Glyceraldehyde
is: C00577
has only substance units: false
is: CHEBI:17378
initial amount: NaN
type: Species
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0

metaR r0651
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110048#
modifier: MODEL1310110048#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110048#

metaR PEAMNO
reversible: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
name: Phenethylamine oxidase
kinetic law: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110048#
is described by: ECO:0000304
fast: false
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.4.3.21

metaM leuktrB4 c
constant: false
name: leukotriene B4(1-)
is: SBO:0000247
has only substance units: false
is: HMDB01085
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461

metaM ppi n
is: CHEBI:33019
boundary condition: false
has only substance units: false
name: diphosphate(3-)
is: SBO:0000247
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_97c37751_0179_4152_a80f_680f5a9b5002
is: P51687
type: Species
initial amount: NaN
name: SUOX
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6821
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_31f9f8f9_b6a4_4e7f_a61d_9f3d39114aa0
boundary condition: true
is: Q15392
initial amount: NaN
constant: false
is: SBO:0000252
name: DHCR24
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1718
type: Species

metaR r1459
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: Transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
type: Reaction

metaR q10h2tc
product: MODEL1310110048#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
is described by: ECO:0000134
name: transport of ubiquinol into cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_6a75d1ca_f99e_4997_ba4d_27b25b5e25d0
is encoded by: hsa:3939
has part: P00338
is encoded by: hsa:3945
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000297
has part: P07195
boundary condition: true
constant: false
initial concentration: NaN
name: LDHA:LDHB

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR 7DHCHSTEROLtr
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
name: cholesterol precursor intracellular transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r0339
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.22
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110048#
reversible: false
product: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_f2d03caf_ef63_426e_94be_42e36f655cb6
is: SBO:0000252
name: NME7
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:29922

metaM his L e
has only substance units: false
name: L-histidine
is: HMDB00177
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:15971

http://identifiers.org/biomodels.db/MODEL1310110048#_05b36835_dbdf_42ee_8bb9_978d6c7d8255
constant: false
initial concentration: NaN
is encoded by: hsa:2643
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: GCH1
boundary condition: true
is: Q8IZH9

http://identifiers.org/biomodels.db/MODEL1310110048#_7cf5ea65_8e70_4f2b_8039_bf7774c0d3f0
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2645
constant: false
boundary condition: true
has only substance units: false
type: Species
name: GCK

metaM pro L m
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
is: CHEBI:17203
is: HMDB00162
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: L-proline
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_5cb8b09e_75ab_460c_bb69_adee8997d2c7
is: SBO:0000252
name: SLCO2A1
is: Q92959
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6578
constant: false

metaM pglyc hs c
initial concentration: 1.0
notes: FORMULA: CHARGE: 0
is: CHEBI:15589
is: SBO:0000247
has only substance units: false
boundary condition: false
name: pglyc_hs[c]
initial amount: NaN
type: Species
constant: false
is: HMDB00156

http://identifiers.org/biomodels.db/MODEL1310110048#_42eca59d_dcac_49f2_a3d7_57dfc272083b
boundary condition: true
is: P26439
has only substance units: false
is encoded by: hsa:3284
is: SBO:0000252
initial concentration: NaN
constant: false
name: HSD3B2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_939cf626_4567_4803_9afb_da3b7b266506
initial concentration: NaN
is encoded by: hsa:3550
is: Q13123
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: IK
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_ffd8cfb9_b3a9_4efc_ba45_1780fc3c90d9
has only substance units: false
boundary condition: true
name: UMPS
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: A8K5J1
is encoded by: hsa:7372
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8e891b4d_52fa_4e35_8f55_827019755351
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:374291
is: O75251
initial concentration: NaN
boundary condition: true
name: NDUFS7
constant: false
has only substance units: false

metaM acgam1p c
type: Species
has only substance units: false
name: N-Acetyl-D-glucosamine 1-phosphate
constant: false
is: CHEBI:7125
initial concentration: 1.0
initial amount: NaN
is: HMDB01367
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256

metaM fprica c
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
constant: false
is: CHEBI:58467
is: HMDB01439
is: SBO:0000247
type: Species
initial amount: NaN
is: C04734
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_7a396c1c_39c2_446c_ad23_f856b0587837
boundary condition: true
name: DGKH
is encoded by: hsa:160851
is: SBO:0000252
is: Q86XP1
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_71f0b5d7_5d8b_467b_ada6_3e10048c611a
has part: P11182
is encoded by: hsa:594
has part: P21953
constant: false
boundary condition: true
is encoded by: hsa:593
is: SBO:0000297
is encoded by: hsa:1629
type: Species
has only substance units: false
initial amount: NaN
name: DBT:DLD:BCKDHA:BCKDHB
has part: B4DP47
initial concentration: NaN

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaR NRPPHRtu
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Norepinephrine uniport
is described by: ECO:0000269
reactant: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_48b97dc5_9fe5_4476_9f2e_b814bf27d04e
boundary condition: true
is encoded by: hsa:26227
has only substance units: false
initial concentration: NaN
is: O43175
constant: false
name: PHGDH
type: Species
initial amount: NaN
is: SBO:0000252

metaM ctp e
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: CTP(4-)
is: HMDB00082
initial concentration: 1.0
boundary condition: false

metaM msa m
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB11111
initial amount: NaN
constant: false
is: CHEBI:33190
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
initial concentration: 1.0
name: 3-oxopropanoate

metaM pan4p e
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: SBO:0000247
name: Pantetheine 4'-phosphate
initial amount: NaN
type: Species
is: HMDB01416
is: C01134

metaR r0650
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000
product: MODEL1310110048#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7

metaR r1010
name: Postulated transport reaction
product: MODEL1310110048#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#

metaR RE2814R
is: SBO:0000176
is described by: ECO:0000000
name: RE2814
reactant: MODEL1310110048#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_4076a557_c7e2_423d_a5df_21838e3500fb
is: SBO:0000252
has only substance units: false
name: PLA2G2D
is encoded by: hsa:26279
initial concentration: NaN
constant: false
is: Q9UNK4
initial amount: NaN
boundary condition: true
type: Species

metaM nad r
is: HMDB00902
name: NAD(1-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
constant: false
is: CHEBI:57540
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003

http://identifiers.org/biomodels.db/MODEL1310110048#_1d261bad_bf92_449f_a794_02b3d2bff409
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:100287639
constant: false
name: _100287639_1_c
type: Species
boundary condition: true

metaM leuktrE4 c
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB02200
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
name: leukotriene E4(1-)
has only substance units: false

metaR SQLEr
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.14.13.132
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000134
fast: false
reversible: false
name: Squalene epoxidase, endoplasmic reticular (NADP)
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#

metaM xoldioloneh c
type: Species
has only substance units: false
is: HMDB06887
is: SBO:0000247
constant: false
is: CHEBI:2288
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
initial amount: NaN

metaM glc D c
type: Species
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:4167
name: D-glucose
initial concentration: 1.0
constant: false

metaM tdchola c
boundary condition: false
type: Species
is: CHEBI:9407
initial concentration: 1.0
name: taurochenodeoxycholate
initial amount: NaN
is: HMDB00951
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
has only substance units: false

metaR r2380
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_91c1423c_2ea9_49ad_a68e_5fad605f9aac
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: Q546Y9
initial amount: NaN
is encoded by: hsa:57379
name: AICDA
is: SBO:0000252

metaR H2Ot
name: H2O transport via diffusion
reactant: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
reversible: true

metaR r1435
kinetic law: MODEL1310110048#
type: Reaction
name: Transport reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_08bd50e8_a67b_4922_948e_aee5eb34e0ff
initial concentration: NaN
name: _AI926493_1_c
is encoded by: hsa:AI926493
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR SERGLNexR
is described by: ECO:0000304
is: SBO:0000185
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110048#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_c16a88d8_03cc_45ee_9068_b6c99784842e
is: SBO:0000252
is encoded by: hsa:4707
initial amount: NaN
has only substance units: false
type: Species
is: O75438
constant: false
boundary condition: true
initial concentration: NaN
name: NDUFB1

metaR PHEACGLNt
fast: false
reversible: true
product: MODEL1310110048#
name: PHEACGLN extracellular transport via diffusion
is: SBO:0000185
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_1e58dc15_50b8_487d_ba58_f6eb039b8a54
type: Species
initial amount: NaN
name: _22305_1_c
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:22305

metaM ala B c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:16958
initial amount: NaN
name: beta-alanine
is: HMDB00056
initial concentration: 1.0
type: Species

metaM cyan c
initial amount: NaN
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
is: SBO:0000247
is: HMDB02084
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d75c3ffb_c1cf_40e9_a685_d3d471859095
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:9334
type: Species
initial amount: NaN
boundary condition: true
name: B4GALT5
initial concentration: NaN
is: O43286

metaR 4HGLSDm
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
kinetic law: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
is described by: ECO:0000212
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_065c5a24_ef02_4157_84bf_0f03e4769203
type: Species
boundary condition: true
name: NOS3
constant: false
is: A0S0A7
is encoded by: hsa:4846
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM HC02149 c
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
initial amount: NaN
is: CHEBI:28867
boundary condition: false
is: SBO:0000247
name: O-Propanoylcarnitine
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4007299d_2cb2_49b1_b49f_e74db3fae6db
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:112724
is: B3KVA3
name: RDH13

metaR r0403
modifier: MODEL1310110048#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110048#

metaM ksi pre15 g
is: CHEBI:58053
initial amount: NaN
constant: false
is: C00130
is: HMDB00175
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 15
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5

metaR DPCOAPPe
reactant: MODEL1310110048#
is described by: ECO:0000134
fast: false
name: Pyrophasphatase (dephospho-CoA, extracellular)
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
type: Reaction

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaR S23T4g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110048#
name: beta-galactoside alpha-2,3-sialyltransferase
reversible: false
product: MODEL1310110048#
modifier: MODEL1310110048#

metaM his L c
initial amount: NaN
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: HMDB00177
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
name: L-histidine

metaR r2065
modifier: MODEL1310110048#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_83b7427c_37e5_45aa_8ab3_2bc6256dfdc7
boundary condition: true
is: P35354
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5743
name: PTGS2
constant: false
has only substance units: false
type: Species

metaR r2381
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false

metaR r1384
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_3579b5c6_76ae_434e_bb83_96b98283f072
name: SRM
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6723
type: Species
is: P19623
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_b6619b0c_36d3_4f8a_802e_42b3dcbe3a7c
boundary condition: true
has only substance units: false
name: FUT8
is: B4DFS7
is: SBO:0000252
is encoded by: hsa:2530
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR ACt2r
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
name: acetate reversible transport via proton symport
is described by: ECO:0000000

metaR r1012
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM dmhptcoa m
initial amount: NaN
type: Species
is: HMDB06258
initial concentration: 1.0
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: 2,6 dimethylheptanoyl-CoA

metaR r0085
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110048#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
is described by: ECO:0000000

metaM din c
type: Species
name: Deoxyinosine
constant: false
is: SBO:0000247
is: HMDB00071
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
has only substance units: false
is: CHEBI:28997
initial concentration: 1.0
is: C05512
boundary condition: false
initial amount: NaN

metaR CYTK3n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
name: cytidylate kinase (dCMP,CTP),nuclear
reversible: true
product: MODEL1310110048#

metaM thymd c
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial amount: NaN
boundary condition: false
name: Thymidine
has only substance units: false
is: C00214
is: HMDB00273
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17748

metaR r2382
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM r1p c
is: SBO:0000247
name: alpha-D-Ribose 1-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
boundary condition: false
is: C00442
type: Species
initial amount: NaN
constant: false
is: CHEBI:57720
is: HMDB01489
initial concentration: 1.0
has only substance units: false

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
name: Gamma-glutamyltransferase
is: SBO:0000176
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true

metaM leuktrE4 e
name: leukotriene E4(1-)
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57462
boundary condition: false
initial concentration: 1.0
is: HMDB02200
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false

metaM CE2424 m
initial amount: NaN
is: SBO:0000247
is: HMDB11123
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false
type: Species
is: CHEBI:28387
initial concentration: 1.0
constant: false
boundary condition: false

metaM 5htrp c
is: SBO:0000247
name: 5-hydroxy-L-tryptophan
initial amount: NaN
is: CHEBI:17780
boundary condition: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00472

metaR GHMT2rm
is version of: http://identifiers.org/ec-code/2.1.2.1
reversible: true
name: glycine hydroxymethyltransferase, reversible, mitochondrial
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000269
modifier: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_f8dd0cca_5569_4523_a758_3f17ad3630fb
is encoded by: hsa:3417
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: O75874
is: SBO:0000252
name: IDH1
boundary condition: true
type: Species

metaR MTHFDm
reversible: true
kinetic law: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
fast: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
modifier: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_0586dc03_4a8b_4ea5_ba36_39d305e2c6b6
is encoded by: hsa:23533
is: SBO:0000297
name: PIK3R5:PIK3CG
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has part: Q8WYR1

metaR r0488
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
kinetic law: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reversible: true

metaR r0655
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
reversible: true
product: MODEL1310110048#

metaM andrstandn r
is: HMDB00899
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15994
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 5alpha-androstane-3,17-dione
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674

metaR NDPK10n
product: MODEL1310110048#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
modifier: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_db83dcd5_4525_4e2e_b5e0_436e28d5f902
is encoded by: hsa:4830
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: NME1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_2ddc3bf8_d479_4a3a_bfb7_eb9e6dc57b73
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: BDH1
is: SBO:0000252
is encoded by: hsa:622
type: Species
constant: false
is: Q02338

http://identifiers.org/biomodels.db/MODEL1310110048#_b85ac0f2_2a0a_4fc9_a6cb_b61ecf69904d
boundary condition: true
is encoded by: hsa:55568
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: GALNT10

metaM C05957 r
boundary condition: false
has only substance units: false
is: HMDB02710
constant: false
initial concentration: 1.0
is: CHEBI:27485
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
name: Prostaglandin J2
initial amount: NaN

metaR r0086
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
modifier: MODEL1310110048#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.5.1.3
product: MODEL1310110048#

metaM din e
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: SBO:0000247
boundary condition: false
is: HMDB00071
has only substance units: false
initial concentration: 1.0
is: C05512
is: CHEBI:28997
constant: false
name: Deoxyinosine
type: Species
initial amount: NaN

metaR r1011
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reversible: false
type: Reaction
is: SBO:0000185
fast: false
name: Transport reaction

metaM 3aib D m
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: C03265
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
constant: false
name: D-3-Amino-isobutanoate
boundary condition: false
is: HMDB02299

metaR DTTPtn
is described by: ECO:0000000
product: MODEL1310110048#
fast: false
name: dTTP diffusion in nucleus
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a2005887_3e5d_4f76_88d6_f61d11daae59
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: MTMR3
is encoded by: hsa:8897
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_0d77f8e8_98aa_4154_902d_db9a1aab5a9b
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:9057
name: SLC7A6
initial concentration: NaN
is: Q92536
is: SBO:0000252
has only substance units: false
type: Species

metaM HC02179 c
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:34306
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
name: 20-hydroxy-arachidonate

metaR GLYSNAT5tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_e38a1c27_eb1f_4e09_ad5c_4eb8e2ff7fd6
has only substance units: false
type: Species
is encoded by: hsa:91373
boundary condition: true
initial amount: NaN
is: Q3KQV9
is: SBO:0000252
constant: false
name: UAP1L1
initial concentration: NaN

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_fc2c8f09_84a7_4549_8476_00971856b8f8
is: P21953
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:594
initial concentration: NaN
name: BCKDHB
boundary condition: true
is: SBO:0000252

metaM nad m
is: CHEBI:57540
initial amount: NaN
initial concentration: 1.0
constant: false
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
is: C00003
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
is: HMDB00902
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_fcd0ee67_ce74_4ffd_8761_0a7a41bd483c
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: _R33828_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:R33828

metaR CHAT
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is described by: ECO:0000269
reversible: true
name: Choline O-acetyltransferase
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110048#
fast: false

metaR COAtr
type: Reaction
product: MODEL1310110048#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110048#
name: COA transporter, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110048#

metaR LDH D
type: Reaction
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000304
is: SBO:0000176
name: D-lactate dehydrogenase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_f0a6bf7c_c72d_43c9_8c3f_c05b6a83be9f
constant: false
name: SLC7A2
initial concentration: NaN
is encoded by: hsa:6542
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: P52569
initial amount: NaN

metaR r0083
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_8f0b0299_c198_457c_a41b_2022558a27bd
is encoded by: hsa:122970
initial amount: NaN
is: Q8N9L9
is: SBO:0000252
constant: false
name: ACOT4
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_dd64b4cd_b940_4a8f_b776_5ac55e36460a
type: Species
boundary condition: true
is encoded by: hsa:6240
initial amount: NaN
is: P23921
initial concentration: NaN
constant: false
name: RRM1
has only substance units: false
is: SBO:0000252

metaR FORMCOAtx
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110048#
name: formyl coa transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction

metaR P4508B13r
reversible: false
fast: false
is described by: ECO:0000269
name: sterol 12-alpha-hydroxylase (nadh)
is version of: http://identifiers.org/ec-code/1.14.13.95
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
kinetic law: MODEL1310110048#
type: Reaction

metaR DOLPMT4 Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110048#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
fast: false

metaR SUCCt2m
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: succinate transport, mitochondrial
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110048#

metaR r2384
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
fast: false
product: MODEL1310110048#
is: SBO:0000185

metaM fe3 c
notes: FORMULA: Fe CHARGE: 3
initial amount: NaN
is: HMDB12943
has only substance units: false
boundary condition: false
name: Fe3+
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

metaM thymd e
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
constant: false
has only substance units: false
is: SBO:0000247
name: Thymidine
is: CHEBI:17748
type: Species
is: HMDB00273
boundary condition: false
initial amount: NaN
is: C00214
initial concentration: 1.0

metaM mthgxl e
is: CHEBI:17158
boundary condition: false
name: methylglyoxal
is: HMDB01167
initial amount: NaN
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

metaR r0408
reversible: true
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
reactant: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:

metaR RE2814M
type: Reaction
name: RE2814
product: MODEL1310110048#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_7b9ed38e_2260_4705_b213_c71b297dd22d
is: C9JC79
constant: false
is encoded by: hsa:6342
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SCP2

metaR UMPKn
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase, nuclear
product: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
reversible: true
is: SBO:0000176

metaM tdcoa x
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
is: HMDB01521
is: C02593
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57385
constant: false
name: Tetradecanoyl-CoA (n-C14:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110048#_fa4a4e59_07e5_4a9d_9cca_0393206af0e7
name: _AA419122_1_c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA419122
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR DHFtm
reversible: true
name: dihydrofolate reversible mitochondrial transport
fast: false
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_1bd2de5f_fc62_43ff_8e2c_07f30362b4ac
is encoded by: hsa:5279
constant: false
name: PIGC
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r0084
modifier: MODEL1310110048#
reversible: true
is: SBO:0000176
type: Reaction
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM lnlccoa c
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
initial amount: NaN
name: linoleic coenzyme A
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: HMDB01064

metaR RE0958E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
name: RE0958
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false

metaM pmtcoa r
has only substance units: false
boundary condition: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: CHEBI:3454
is: SBO:0000247
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
type: Species
is: HMDB01338
initial amount: NaN

metaR r2385
fast: false
product: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110048#

metaR LNLNCGt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is: SBO:0000185
product: MODEL1310110048#
name: fatty acid transport via diffusion
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_d026fe79_61e0_466b_bca4_d75fd9ce4fff
initial amount: NaN
type: Species
is encoded by: hsa:171425
boundary condition: true
initial concentration: NaN
name: CLYBL
constant: false
is: SBO:0000252
has only substance units: false

metaR ITCOALm
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
is described by: ECO:0000212
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176

metaR r0407
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110048#
product: MODEL1310110048#
reversible: true
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
fast: false
kinetic law: MODEL1310110048#

metaM ksii core4 deg1 l
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: HMDB00868
is: CHEBI:57737
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 1
is: SBO:0000247
type: Species

metaM adrn e
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:53487
name: adrenic acid
is: HMDB02226
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110048#_c22b9c3b_927d_4d8f_bc25_2de98bfa2830
initial concentration: NaN
is: Q4KWH8
is: SBO:0000252
name: PLCH1
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:23007
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6114ab7a_4468_4bf2_a198_a4120ea3d8a3
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:6514
is: SBO:0000252
name: SLC2A2
initial amount: NaN
constant: false
has only substance units: false
is: P11168

metaM CE5786 e
is: SBO:0000247
is: HMDB02710
is: CHEBI:27485
boundary condition: false
type: Species
constant: false
name: kinetensin
has only substance units: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_1020a0d5_7a40_40a9_90c3_d22fd68cb010
boundary condition: true
type: Species
is encoded by: hsa:10870
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9UBK5
name: HCST
constant: false
is: SBO:0000252

metaR FAOXTC101TC102m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaR r1656
fast: false
is: SBO:0000185
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_045b29de_8ab1_4eef_8fdd_adfdacdd925e
type: Species
initial concentration: NaN
is encoded by: hsa:3158
constant: false
is: P54868
has only substance units: false
boundary condition: true
is: SBO:0000252
name: HMGCS2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_9dda0436_018e_406f_b862_d1a46a7043c6
is encoded by: hsa:4702
name: NDUFA8
is: B1AM93
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_cae65d85_2c63_4073_8e43_71b3319cd861
has only substance units: false
name: COX6C
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: P09669
is: SBO:0000252
constant: false
is encoded by: hsa:1345

metaR FAOXC226m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR SEBCOAPET
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM dtdp c
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01274
constant: false
is: C00363
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: dTDP
is: CHEBI:58369

metaR AG13T18g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR RE1530C
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
product: MODEL1310110048#
name: RE1530
type: Reaction
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_1c703f58_bb2a_4090_b174_ce76ddcb322e
constant: false
name: CA6
is: Q5FC00
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:765
type: Species
initial amount: NaN

metaR EHGLAT2m
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
is described by: ECO:0000304
type: Reaction
product: MODEL1310110048#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
is: SBO:0000176

metaR CHOLtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: choline intracellular transport
reactant: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_b88ee16c_55b0_4f6f_8a0d_ab917ae55261
is: SBO:0000252
name: PIGA
type: Species
initial amount: NaN
is encoded by: hsa:5277
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b4b031a1_2df4_437f_a0fe_70bcdb4831c1
initial concentration: NaN
name: CA4
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: Q6FHI7
is encoded by: hsa:762

metaM CE0693 m
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:28387
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
is: HMDB11123
name: 3-oxolaur-6-cis-enoyl-CoA
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_fb83bac9_bb9e_42f3_9ab5_c1abfaa72db2
is: SBO:0000252
has only substance units: false
is: P40926
is encoded by: hsa:4191
name: MDH2
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM dgtp c
initial concentration: 1.0
is: HMDB01440
is: C00286
is: SBO:0000247
is: CHEBI:16497
has only substance units: false
initial amount: NaN
name: dGTP
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false

metaM dcholcoa x
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
boundary condition: false
is: CHEBI:28701
is: HMDB06292
has only substance units: false
constant: false
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
type: Species
initial concentration: 1.0

metaR DNDPt29m
reversible: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
type: Reaction
fast: false
name: dCDP transport via dADP antiport
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_a6224bdf_d5e8_4eb5_9761_433139746503
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: P13866
is encoded by: hsa:6523
initial concentration: NaN
name: SLC5A1

http://identifiers.org/biomodels.db/MODEL1310110048#_06ed74f8_3b91_40ff_978e_618b4254c65f
is encoded by: hsa:3418
boundary condition: true
initial amount: NaN
is: P48735
is: SBO:0000252
name: IDH2
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaM ctp n
initial concentration: 1.0
is: CHEBI:37563
type: Species
initial amount: NaN
constant: false
name: CTP(4-)
boundary condition: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
is: HMDB00082
is: SBO:0000247

metaM cit m
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
initial concentration: 1.0
name: Citrate
has only substance units: false
is: CHEBI:16947

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_05a653b2_06f6_45ae_8465_d0b6d89caaa1
name: LDHC
is: P07864
is encoded by: hsa:3948
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaR r1655
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
fast: false

metaR r2532
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_730430e5_198a_4187_bd12_3d37daa405f6
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q9UEF7
has only substance units: false
constant: false
is encoded by: hsa:9365
name: KL
type: Species

metaR r1018
type: Reaction
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
name: Transport reaction
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM co2 r
is: CHEBI:16526
is: SBO:0000247
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
type: Species
has only substance units: false
initial amount: NaN
name: CO2
initial concentration: 1.0
is: C00011
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_fc9c4324_c1b6_4295_a15e_ec6ecbeff90f
constant: false
has only substance units: false
is encoded by: hsa:R14373
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: _R14373_1_x

http://identifiers.org/biomodels.db/MODEL1310110048#_60c4d15f_43c3_44e4_a20c_7d3b28f1b734
is encoded by: hsa:D29675
name: _D29675_1_c
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR G14T15g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM chlstol r
is: HMDB06842
type: Species
is: CHEBI:16290
constant: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR BALAtmr
name: Beta-alanine reversible mitochondrial transport (diffusion)
product: MODEL1310110048#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB

metaR ALAGLNexR
modifier: MODEL1310110048#
fast: false
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110048#
name: L-alanine/glutamine reversible exchange
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR CHOLtu
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
modifier: MODEL1310110048#
name: Choline uniport
reactant: MODEL1310110048#
product: MODEL1310110048#

metaR HGNTOR
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.5
fast: false
reactant: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR GNMT
is version of: http://identifiers.org/ec-code/2.1.1.20
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269
type: Reaction
reversible: false
name: glycine N-methyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9af3fe31_f1f8_4620_8b39_d1270ea3ccd6
is: SBO:0000252
is encoded by: hsa:8639
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: AOC3
type: Species
constant: false
is: Q16853

http://identifiers.org/biomodels.db/MODEL1310110048#_a65bb480_609e_47ec_8375_6b819ef879d9
is: P54819
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: AK2
is encoded by: hsa:204
constant: false
boundary condition: true
initial amount: NaN

metaM HC01397 x
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: SBO:0000247
is: CHEBI:27402
boundary condition: false
constant: false
initial amount: NaN

metaR r1654
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110048#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR ACCOAgt
is: SBO:0000185
fast: false
reactant: MODEL1310110048#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
name: acetyl-coa transport
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
type: Reaction

metaR NADHtru
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: NADH transporter, endoplasmic reticulum
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
reactant: MODEL1310110048#

metaR P45027A11m
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000269
product: MODEL1310110048#
type: Reaction
reversible: false
reactant: MODEL1310110048#

metaM CE0849 m
is: SBO:0000247
has only substance units: false
is: CHEBI:57795
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
name: cis,cis-palmito-7,10-dienoyl-CoA

metaM dtdp e
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:58369

metaM adrn c
boundary condition: false
constant: false
name: adrenic acid
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
is: CHEBI:53487
type: Species
is: HMDB02226

http://identifiers.org/biomodels.db/MODEL1310110048#_0fab8796_d046_4720_8436_2c95cc73b05b
has part: B4DER4
is encoded by: hsa:5295
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PIK3CB:PIK3R1
has part: B3KT19
is encoded by: hsa:5291
is: SBO:0000297
constant: false
type: Species

metaM pect e
constant: false
boundary condition: false
name: pectins
is: SBO:0000247
is: HMDB03402
type: Species
initial concentration: 1.0
notes: FORMULA: C2535H3509O2535 CHARGE: -1
has only substance units: false
initial amount: NaN

metaM 3mgcoa m
is: SBO:0000247
name: trans-3-methylglutaconyl-CoA(5-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01057
is: CHEBI:57346
initial amount: NaN
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
constant: false
type: Species

metaR r2535
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
type: Reaction

metaR NADS2
reversible: false
reactant: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110048#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.1
kinetic law: MODEL1310110048#
name: NAD synthase (glutamine-hydrolysing)
product: MODEL1310110048#

metaR UDPGLCter
is described by: ECO:0000000
type: Reaction
fast: false
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaM mthgxl c
has only substance units: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
constant: false
initial amount: NaN
type: Species
name: methylglyoxal
initial concentration: 1.0
is: SBO:0000247
is: HMDB01167
boundary condition: false
is: CHEBI:17158

metaM dhlam m
name: dihydrolipoamide
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
type: Species
is: HMDB00985
is: SBO:0000247
is: CHEBI:17694
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8313e517_0571_4507_a358_6786022851ca
boundary condition: true
name: SDHB
type: Species
is: P21912
has only substance units: false
is encoded by: hsa:6390
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_f923273b_e4e5_461a_824a_dfd83ae6919e
has only substance units: false
boundary condition: true
initial amount: NaN
name: MPST
is: SBO:0000252
is: P25325
constant: false
type: Species
is encoded by: hsa:4357
initial concentration: NaN

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_2ebd122a_ce66_4d80_9485_917801e9c297
has only substance units: false
name: SDHD
initial amount: NaN
is encoded by: hsa:6392
boundary condition: true
is: O14521
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_79288bf9_1a1f_4fdb_b6eb_d403bc99c915
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: ALDH1A2
initial amount: NaN
is: B4DZR2
is: SBO:0000252
is encoded by: hsa:8854
boundary condition: true

metaR ACONTm
is: SBO:0000176
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
modifier: MODEL1310110048#
product: MODEL1310110048#
name: Aconitate hydratase
type: Reaction
fast: false
reactant: MODEL1310110048#

metaM 4h2oglt m
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: 4-hydroxy-2-oxoglutarate(2-)
is: HMDB02070
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: SBO:0000247
is: CHEBI:17742

metaR THBPT4ACAMDASE
reactant: MODEL1310110048#
fast: false
type: Reaction
modifier: MODEL1310110048#
is described by: ECO:0000269
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is: SBO:0000176
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_1980722a_163a_40c4_af61_797503a472eb
is: SBO:0000252
is encoded by: hsa:83715
initial concentration: NaN
type: Species
initial amount: NaN
is: B1AK53
has only substance units: false
boundary condition: true
name: ESPN
constant: false

metaR FE3MTP1
kinetic law: MODEL1310110048#
reversible: false
name: transport of ferrous iron into blood
type: Reaction
is: SBO:0000185
reactant: MODEL1310110048#
is described by: ECO:0000134
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

metaR r1653
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
type: Reaction

metaM dgtp e
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01440
is: CHEBI:16497
name: dGTP
boundary condition: false
constant: false
has only substance units: false
type: Species

metaM nicrns c
is: CHEBI:58527
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: Nicotinate D-ribonucleoside
is: HMDB06809
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4e90a528_2a06_4405_83fe_af247adef5cd
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC23A2
is: Q9UGH3
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9962

metaR LNLCt
product: MODEL1310110048#
name: Linoleic acid (n-C18:2) transport in via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM lnlnca c
initial amount: NaN
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial concentration: 1.0
is: HMDB01388
name: alpha-linolenate
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:32387
is: SBO:0000247

metaR r0410
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is described by: ECO:0000000

metaR INSTt4 2
kinetic law: MODEL1310110048#
is: SBO:0000185
reversible: true
name: inositol transport via sodium symport
is described by: ECO:0000006
reactant: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
fast: false
type: Reaction

metaR C4STMO2r
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.72
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#
name: C-4 methyl sterol oxidase

http://identifiers.org/biomodels.db/MODEL1310110048#_5273050c_4e42_441c_95d7_3acc276b4c2f
name: CHAT
initial concentration: NaN
has only substance units: false
is: P28329
initial amount: NaN
is encoded by: hsa:1103
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_44008cc8_e54e_4b42_a28e_4d4498599df5
is encoded by: hsa:U37519
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: _U37519_1_e

metaM ksi pre28 g
constant: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 28
type: Species
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00130
boundary condition: false
is: SBO:0000247

metaM leuktrD4 c
name: Leukotriene D4
has only substance units: false
is: SBO:0000247
is: CHEBI:28666
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
boundary condition: false
initial amount: NaN
is: HMDB03080
initial concentration: 1.0

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR RE3050R
kinetic law: MODEL1310110048#
name: RE3050
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:

metaM retinol 9 cis c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
type: Species
name: 9-cis-retinol
constant: false
is: HMDB06217
boundary condition: false
is: SBO:0000247
is: CHEBI:17336
initial amount: NaN

metaM 3hibutcoa m
is: HMDB01052
constant: false
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
name: (S)-3-Hydroxyisobutyryl-CoA
is: SBO:0000247
is: CHEBI:28259
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR ASNSERNaEx
reversible: false
is: SBO:0000185
product: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
fast: false
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110048#_a42a69d8_c5e3_4d87_a9c8_0c46dca1ae4c
type: Species
initial amount: NaN
name: NT5C2
has only substance units: false
is: P49902
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:22978

http://identifiers.org/biomodels.db/MODEL1310110048#_5a6cf8bb_473c_44f9_aebf_4e20a81a5315
initial amount: NaN
name: GAPDHS
constant: false
is encoded by: hsa:26330
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: O14556

metaM pser L c
is: HMDB01721
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:15811
is: SBO:0000247
name: O-Phospho-L-serine

metaR NDPK9n
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110048#

metaR AG13T11g
type: Reaction
reversible: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_9e883135_fdfb_45e7_be18_085f00a46863
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI972237
is: SBO:0000252
name: _AI972237_1_c
constant: false
type: Species
initial concentration: NaN

metaM ade c
is: SBO:0000247
constant: false
is: CHEBI:16708
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: C00147
boundary condition: false
type: Species
is: HMDB00034
initial amount: NaN
initial concentration: 1.0
name: Adenine
has only substance units: false

metaM g3m8mpdol U r
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
is: SBO:0000247
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: C05873

http://identifiers.org/biomodels.db/MODEL1310110048#_9c752f7d_4969_42fe_a398_2955ff0f6135
is: Q9UIG8
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLCO3A1
is encoded by: hsa:28232
type: Species
initial concentration: NaN

metaR SERGLNNaEx
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000269
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
reversible: false
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b65b3447_a993_47c2_a46b_32f6161c38b6
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: _AI640625_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI640625
constant: false

metaM for c
is: SBO:0000247
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate
boundary condition: false
type: Species
constant: false
is: C00058
is: HMDB00142
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR HIStN1
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Histidine transport (Na, H coupled)
kinetic law: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_fc48aec3_8a96_4f71_bd65_1b47de3a0b91
is: Q9UNP4
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: ST3GAL5
is encoded by: hsa:8869

http://identifiers.org/biomodels.db/MODEL1310110048#_fc12ec16_0e9d_44ca_a84c_916092f96cec
constant: false
initial concentration: NaN
is: Q99714
type: Species
boundary condition: true
initial amount: NaN
name: HSD17B10
has only substance units: false
is encoded by: hsa:3028
is: SBO:0000252

metaM oaa m
is: HMDB00223
is: CHEBI:16452
type: Species
is: C00036
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Oxaloacetate
constant: false
initial amount: NaN
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

http://identifiers.org/biomodels.db/MODEL1310110048#_f21fbddb_3e13_49bb_af25_41f86aecde16
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q969K7
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:113452
name: TMEM54

metaM dectricoa m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
name: 2,4,7-decatrienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM HC01434 m
initial amount: NaN
is: CHEBI:58931
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: oxalatosuccinate(3-)
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6cdb58ef_50bf_435f_9b87_52e8b9c94417
is: P48651
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9791
initial concentration: NaN
name: PTDSS1
has only substance units: false
initial amount: NaN

metaR r1659
is described by: ECO:0000000
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185
product: MODEL1310110048#

metaM gchola e
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0
initial concentration: 1.0
is: HMDB00138
name: glycocholate
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ed266bb3_8d06_45c0_bf23_89a36a9452f0
is encoded by: hsa:6574
type: Species
constant: false
is: Q8WUM9
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC20A1
boundary condition: true

metaM dadp n
name: dADP(3-)
is: CHEBI:57667
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
is: HMDB01508
boundary condition: false
type: Species

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM for e
constant: false
type: Species
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: formate
initial concentration: 1.0
is: HMDB00142
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR UMPK3n
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP),nuclear

metaR CHOLtn
fast: false
type: Reaction
name: Choline transport, nuclear through pores
is: SBO:0000185
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it

http://identifiers.org/biomodels.db/MODEL1310110048#_bb984769_f9fd_435b_b134_a919d689fbb4
constant: false
type: Species
initial concentration: NaN
is: P19174
has only substance units: false
is encoded by: hsa:5335
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PLCG1

metaM docosahexcoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
name: 3,7,10,13,16,19-docosahexenoylcoa
has only substance units: false
constant: false
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM c10dc c
notes: FORMULA: C17H30NO6 CHARGE: -1
name: sebacoyl carnitine
initial amount: NaN
is: C14143
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB04047
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_13ed0d6e_7432_4c07_a8d4_68047fbff3ac
has only substance units: false
constant: false
is: SBO:0000252
is: Q16706
name: MAN2A1
initial amount: NaN
is encoded by: hsa:4124
initial concentration: NaN
type: Species
boundary condition: true

metaM 4mzym int1 r
constant: false
initial concentration: 1.0
is: HMDB06927
initial amount: NaN
name: 4-Methylzymosterol intermediate 1
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR r0860
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
name: Utilized transport
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reversible: true
modifier: MODEL1310110048#

metaR URIt5le
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: uridine transport in via sodium symport (1:2)
reactant: MODEL1310110048#
is: SBO:0000185
reversible: false
is described by: ECO:0000134
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM lnlnca e
is: HMDB01388
is: CHEBI:32387
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
name: alpha-linolenate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_88f34133_5ef4_42d5_aed8_fe6eb4f42545
initial concentration: NaN
constant: false
has only substance units: false
name: ALDH3B2
is: SBO:0000252
initial amount: NaN
is: P48448
type: Species
is encoded by: hsa:222
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_96eda04f_e6d8_4a1c_b995_79afc025f125
is: P51648
is encoded by: hsa:224
name: ALDH3A2
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM ala B e
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16958
boundary condition: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
has only substance units: false
name: beta-alanine

metaR r1658
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_a9195d5d_3c68_4d79_8566_0f3020836748
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23236
initial amount: NaN
type: Species
boundary condition: true
name: PLCB1
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d308615d_c4b8_4da2_8838_86b8491536af
has only substance units: false
is encoded by: hsa:5167
type: Species
is: P22413
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ENPP1
constant: false
initial amount: NaN

metaR r1019
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction

metaR MAL Lte
name: Transport of L-malate
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110048#_d2b22584_37aa_4a91_8694_3c39d1f5000b
initial concentration: NaN
is: Q9H0N5
name: PCBD2
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:84105

metaM HC01602 c
is: CHEBI:57454
constant: false
name: 10-Formyltetrahydrofolate
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_320e4a2a_47fb_4d2c_b32f_0f99687e6ae7
boundary condition: true
type: Species
name: NDUFS3
initial amount: NaN
is encoded by: hsa:4722
is: SBO:0000252
constant: false
initial concentration: NaN
is: O75489
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9708a0e2_98a5_4e9b_bf1e_63b82f1d7002
is encoded by: hsa:586
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P54687
constant: false
name: BCAT1
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_c434420e_20fb_4e1e_bb2c_5ff67ffe2695
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: GSTZ1
is encoded by: hsa:2954
is: SBO:0000252
has only substance units: false

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_bc78f885_7ec2_4be8_8b1a_3d93c4659974
type: Species
has part: P37287
is encoded by: hsa:8818
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:5277
boundary condition: true
has only substance units: false
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false

metaR r1657
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
reversible: true
product: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#

metaR NADtx
reactant: MODEL1310110048#
is described by: ECO:0000134
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of NAD into peroxisome
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_cb322740_b5d2_4160_9715_b7f16baa1b7a
name: CYP2C19
is encoded by: hsa:1557
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: P33261
is: SBO:0000252

metaR PGISr
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.4
reversible: true
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
name: Prostaglandin I2 synthase
is described by: ECO:0000134
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_8b530813_43b4_4022_8cbb_d2499f57f96e
constant: false
has only substance units: false
is encoded by: hsa:6240
initial amount: NaN
is: P23921
is: SBO:0000252
boundary condition: true
type: Species
name: RRM1
initial concentration: NaN

metaM atp e
initial concentration: 1.0
name: ATP(4-)
is: HMDB00538
is: CHEBI:57299
is: C00002
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247

metaR ALAGLNNaEx
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110048#
reversible: false
is: SBO:0000185
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000269

metaM m5masnC g
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: CHEBI:58433
type: Species
constant: false
is: HMDB02985
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_ed2ee5fa_11c5_40a6_9b3b_41345c43da09
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ST3GAL3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6487
type: Species

metaR LEUt4
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
fast: false
modifier: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
reversible: false
is described by: ECO:0000269
product: MODEL1310110048#
name: L-leucine transport in via sodium symport
reactant: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_5b7a66b1_c1a3_42de_8934_7f16ee940db5
initial amount: NaN
constant: false
name: _AA502753_1_m
boundary condition: true
is encoded by: hsa:AA502753
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_fcda1893_b2aa_4d6e_9658_9b019b6934c3
type: Species
initial concentration: NaN
name: _LOC374569_1_e
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:LOC374569
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_bc1765af_d3df_42e8_8b40_790262376eb9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6520
name: SLC3A2
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: P08195

metaM man l
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-mannose
initial concentration: 1.0
type: Species
is: HMDB00169
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16024
constant: false

metaM HC00591 c
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial concentration: 1.0
name: 2-oxoglutaramate
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:16769
is: SBO:0000247

metaM glc D r
is: HMDB00122
is: CHEBI:4167
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: D-glucose

metaR DITPtn
product: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
name: dITP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110048#
is: SBO:0000185
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_3d65834d_a72f_465a_a583_b0c809fa2cf7
type: Species
initial amount: NaN
is encoded by: hsa:5332
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q15147
has only substance units: false
boundary condition: true
name: PLCB4

metaR r0142
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
product: MODEL1310110048#
fast: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#

metaM g2m8masn r
boundary condition: false
type: Species
is: C05874
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_4ed8231e_507f_448d_9eca_11940845e593
is: Q11201
is: SBO:0000252
name: ST3GAL1
is encoded by: hsa:6482
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR XYLTD Dr
reactant: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
kinetic law: MODEL1310110048#
type: Reaction
name: xylitol dehydrogenase (D-xyulose-forming)
is: SBO:0000176

metaM HC01609 e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: UroporphyrinogenI
is: SBO:0000247
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: CHEBI:28766
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4ec2f829_b023_4d35_bd24_f6f4f6e84672
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: _AA614647_1_c
is encoded by: hsa:AA614647
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_e29b1c0f_55a1_4b41_b682_1b24f5a4ff2d
has only substance units: false
boundary condition: true
is encoded by: hsa:771
type: Species
constant: false
initial amount: NaN
is: O43570
is: SBO:0000252
name: CA12
initial concentration: NaN

metaR DTDPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110048#
is: SBO:0000185
name: dTDP nuclear transport
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
fast: false

metaR AICART
kinetic law: MODEL1310110048#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.3
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is: SBO:0000176
type: Reaction
name: phosphoribosylaminoimidazolecarboxamide formyltransferase

metaR FAOXTC182TC162m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaM HC02208 c
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
is: CHEBI:27696
has only substance units: false
name: prostaglandin-d1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_902fa723_b62e_422f_abde_d939eb1c4260
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: Q9NUB1
name: ACSS1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:84532

metaR ORNt4m
fast: false
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
name: ornithine mitochondrial transport exchange with citruline
modifier: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_d722149b_7f30_4d04_b3a3_587747d0cd50
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: PLCD4
boundary condition: true
is: Q9BRC7
is encoded by: hsa:84812
has only substance units: false
constant: false

metaM dopa c
is: CHEBI:59905
is: HMDB00073
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
name: dopaminium(1+)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_aa779f43_afaf_41cc_9381_ef1388076a62
boundary condition: true
is: Q9BV79
is: SBO:0000252
has only substance units: false
name: MECR
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:51102
initial concentration: NaN

metaR ALATHRNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
kinetic law: MODEL1310110048#
is described by: ECO:0000269
fast: false
type: Reaction

metaR S6T3g
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.21
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110048#

metaR GULN3D
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
name: L-gulonate 3-dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true

metaR DOLDPP Uer
product: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.6.1.43
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
reversible: false
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#

metaM ahcys c
type: Species
is: CHEBI:16680
initial amount: NaN
has only substance units: false
is: HMDB00939
initial concentration: 1.0
constant: false
is: C00021
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
boundary condition: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_4adc886a_b741_4289_9efc_98ae25ba7808
type: Species
initial amount: NaN
initial concentration: NaN
name: FOLR1
is encoded by: hsa:2348
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR DOLPMT1 Uer
modifier: MODEL1310110048#
is described by: ECO:0000000
fast: false
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176
type: Reaction
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_00391fd1_239e_43ad_81b0_3b82adcd2f59
constant: false
name: _206_1_c
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:206
is: SBO:0000252
initial concentration: NaN

metaM cit e
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: citrate(3-)
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
type: Species
is: HMDB00094

http://identifiers.org/biomodels.db/MODEL1310110048#_96f87ae3_402f_4fd2_8b32_4439b8759406
is encoded by: hsa:5313
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: PKLR
type: Species
has only substance units: false
initial concentration: NaN

metaM 4abut e
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
name: 4-Aminobutanoate
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:3628
is: SBO:0000247
constant: false
is: C00334
is: HMDB00112

metaM glutcoa m
has only substance units: false
is: CHEBI:57378
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
constant: false
name: glutaryl-CoA(5-)
is: HMDB01339
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_a00837d6_b8f4_4615_b71b_69972869304b
is: Q9NY65
name: EHHADH
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1962
has only substance units: false
constant: false

metaR r1912
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110048#
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_5ea8fce9_3653_4523_a5c2_818ac570137e
is: E7EX19
initial concentration: NaN
constant: false
name: PIK3R1
is encoded by: hsa:5295
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_5c385bf9_6aa9_4981_a1ce_57936eff7a18
is encoded by: hsa:3158
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P54868
name: HMGCS2
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_bbdaa2e4_8746_44e7_9d88_f644ac729e9d
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:5169
name: ENPP3
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q308M7
has only substance units: false

metaR PE HStm
is: SBO:0000185
name: phosphatidylethanolamine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_8aff8882_26b4_4acc_941a_9fb62316ea60
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: DGKZ
is encoded by: hsa:8525
is: G3V0F6
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_61663569_5310_41ef_acc6_aa40528a0e89
is: A6NFM2
is encoded by: hsa:5831
constant: false
name: PYCR1
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_82d71952_187c_4f77_9b92_c724f76e250a
name: TM7SF2
type: Species
constant: false
boundary condition: true
is: O76062
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7108
is: SBO:0000252

metaM man g
initial amount: NaN
is: SBO:0000247
is: CHEBI:16024
type: Species
constant: false
name: D-mannose
has only substance units: false
initial concentration: 1.0
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false

metaM C02528 c
constant: false
is: CHEBI:36234
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00518
initial amount: NaN
type: Species
has only substance units: false

metaR r1873
product: MODEL1310110048#
fast: false
is: SBO:0000185
reversible: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_a717c806_b921_4235_9ddc_b475bc3126ce
boundary condition: true
is: Q9BYC2
name: OXCT2
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:64064

http://identifiers.org/biomodels.db/MODEL1310110048#_4522fd87_cf02_4540_af9c_f925bb25a347
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: PIGK
initial amount: NaN
is encoded by: hsa:10026
type: Species
has only substance units: false
is: Q92643

metaM dgtp n
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
is: CHEBI:16497
name: dGTP
is: HMDB01440
is: C00286
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaM oaa c
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: C00036
is: CHEBI:3338
notes: FORMULA: C4H2O5 CHARGE: -2
has only substance units: false
name: Oxaloacetate
initial concentration: 1.0
type: Species
is: HMDB00223

metaR DCSPTN1COAtx
name: fatty acid intracellular transport
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaM HC02208 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: prostaglandin-d1
is: CHEBI:27696
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR CYTK9n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110048#
name: cytidylate kinase (CMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM dtdp m
has only substance units: false
is: C00363
is: CHEBI:58369
name: dTDP
boundary condition: false
is: HMDB01274
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

metaM adp c
is: CHEBI:16761
is: C00008
name: ADP
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3310
boundary condition: false
is: HMDB01341
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

metaM CE2839 e
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: SBO:0000247
boundary condition: false
name: maltodecaose
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5041
is: C01936

metaM atp r
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: HMDB00538
initial concentration: 1.0
name: ATP(4-)
is: C00002
is: CHEBI:57299

metaR r1874
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_6c92e47e_09b0_45cb_83f8_3101b253943f
name: UEVLD
is encoded by: hsa:55293
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is: Q8IX04
boundary condition: true
initial concentration: NaN

metaM dcholcoa r
initial concentration: 1.0
has only substance units: false
is: CHEBI:28701
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
is: HMDB06292
is: SBO:0000247
constant: false
type: Species

metaM ksi pre13 g
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 13
initial concentration: 1.0
constant: false
is: C00130
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
has only substance units: false
is: HMDB00175
type: Species
is: CHEBI:58053
initial amount: NaN
boundary condition: false

metaR GTHOm
modifier: MODEL1310110048#
is: SBO:0000176
type: Reaction
name: glutathione oxidoreductase
reactant: MODEL1310110048#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000254

metaM dtdp n
is: HMDB01274
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM cit c
is: C00158
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16947
boundary condition: false
type: Species
is: HMDB00094

metaM 3hmbcoa m
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: HMDB01356
is: CHEBI:57312
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0

metaM 4abut c
initial concentration: 1.0
is: C00334
is: HMDB00112
type: Species
is: CHEBI:3628
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaM co2 x
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16526
constant: false
name: carbon dioxide
boundary condition: false

metaR CERT1gt
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
product: MODEL1310110048#
name: ceramide transport protein
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000304
kinetic law: MODEL1310110048#

metaR COAtg
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110048#
fast: false
name: CoA transport in Golgi via diffusion

http://identifiers.org/biomodels.db/MODEL1310110048#_bc1ce777_7b87_4204_88cb_541c3ff428fa
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PLA2G2F
is: Q9BZM2
has only substance units: false
is encoded by: hsa:64600
constant: false
initial amount: NaN
type: Species

metaR ACNMLr
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
name: N-Acetylneuraminate lyase (reversible)
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000176

metaR r1914
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#
name: Y+LAT2 Utilized transport
product: MODEL1310110048#
type: Reaction

metaR r2200
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110048#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110048#

metaR FAOXC165C164m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaM Ser Thr g
name: protein-linked serine or threonine residue (O-glycosylation site)
boundary condition: false
constant: false
is: C00124
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:0
is: HMDB00143
notes: FORMULA: XH CHARGE: 0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_8e8e49c7_7e13_4e6e_8d3e_226006d660fc
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:30
name: ACAA1
is: Q96CA6
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR GHMT2r
is described by: ECO:0000269
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
fast: false
modifier: MODEL1310110048#
name: glycine hydroxymethyltransferase, reversible
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.1
kinetic law: MODEL1310110048#

metaM dolmanp L r
type: Species
initial amount: NaN
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
has only substance units: false
is: CHEBI:15809
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8bbba97f_a204_43ab_bba6_97b1dcc57b19
name: PIGT
has only substance units: false
is encoded by: hsa:51604
initial concentration: NaN
type: Species
is: Q969N2
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_5656de9c_a848_4348_b78f_34e188dacdd8
has part: P04843
is encoded by: hsa:1603
type: Species
is encoded by: hsa:6185
is: SBO:0000297
has part: P39656
name: DAD1:DDOST:RPN1:RPN2
initial amount: NaN
initial concentration: NaN
has part: Q53G02
has only substance units: false
has part: P04844
boundary condition: true
is encoded by: hsa:1650
constant: false
is encoded by: hsa:6184

metaM ksi deg1 e
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 1
boundary condition: false
type: Species
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: HMDB00211
is: CHEBI:17268

http://identifiers.org/biomodels.db/MODEL1310110048#_c6bbc040_0199_4214_b2b1_b85707c26ac6
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: PANK2
is: SBO:0000252
is encoded by: hsa:80025
initial amount: NaN
has only substance units: false

metaR AHCYSte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110048#
name: Transport of S-adenosyl-L-homocysteine
type: Reaction
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_72b06b62_1dc6_4d4b_bda0_37c123c1c016
is: P78542
initial concentration: NaN
name: HK1
is encoded by: hsa:3098
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_d1dfdeeb_bbbd_4b13_a947_6635022858c9
is: SBO:0000252
is encoded by: hsa:10449
type: Species
name: ACAA2
constant: false
initial amount: NaN
boundary condition: true
is: P42765
initial concentration: NaN
has only substance units: false

metaR r1652
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000

metaR PRODt2r
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
reactant: MODEL1310110048#
name: D-proline reversible transport via proton symport
is described by: ECO:0000304

metaR RE0691C
reactant: MODEL1310110048#
name: RE0691
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
is described by: ECO:0000000

metaM atp n
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: HMDB00538
is: CHEBI:57299
constant: false
name: ATP(3-)

metaM HC01842 c
is: SBO:0000247
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:31997
name: Phosphodimethylethanolamine
has only substance units: false
type: Species
constant: false

metaM ksii core4 pre10 g
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
is: CHEBI:28067
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR r1917
modifier: MODEL1310110048#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110048#
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction

metaM pail45p hs c
type: Species
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
initial concentration: 1.0

metaM nm2masn g
is: C05884
initial concentration: 1.0
notes: FORMULA: C42H70N3O30X CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
constant: false
initial amount: NaN

metaR r2537
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110048#
reversible: true
is: SBO:0000185
reactant: MODEL1310110048#
name: Utilized transport
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_a945730b_5780_400c_81d2_80c508fa0adb
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC5A8
is encoded by: hsa:160728
is: Q8N695
type: Species
boundary condition: true
constant: false

metaR RE1342C
is: SBO:0000176
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
fast: false
type: Reaction
name: RE1342
kinetic law: MODEL1310110048#

metaM tmndnccoa c
constant: false
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
is: HMDB06514
initial concentration: 1.0
name: timnodonyl coenzyme A
boundary condition: false
initial amount: NaN
has only substance units: false

metaR PPD2CSPp
fast: false
name: PPD2CSPp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
is: SBO:0000176
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
type: Reaction

metaR EX bildglcur LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin beta-diglucuronide exchange
type: Reaction

metaM Lpipecol x
has only substance units: false
name: L-pipecolic acid
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: CHEBI:30913
initial amount: NaN
is: HMDB00716

metaR C226COAtx
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
fast: false
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_61a86dd8_27f2_45f2_9c21_fb6a5cabfe3b
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:9651
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: PLCH2
is: O75038

metaM leuktrD4 e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
boundary condition: false
is: CHEBI:28666
type: Species
constant: false
name: Leukotriene D4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_65cbcc4d_54fd_4bfa_b3c7_cb470a3e8798
has only substance units: false
boundary condition: true
constant: false
is: O95167
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4696
initial amount: NaN
name: NDUFA3

metaR r1651
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR r1876
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_ee18a7c5_c6fa_4535_9427_a83af093c39e
initial amount: NaN
initial concentration: NaN
is: B4E3E9
type: Species
is: SBO:0000252
has only substance units: false
name: OGDH
boundary condition: true
is encoded by: hsa:4967
constant: false

metaM ca2 c
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00464
is: SBO:0000247
constant: false
is: CHEBI:29108
name: calcium(2+)
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_122a7779_2b77_4701_ae17_d1007dee9005
has only substance units: false
is: Q9H0P0
constant: false
name: NT5C3
type: Species
initial amount: NaN
is encoded by: hsa:51251
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM 3octpencoa m
name: 3,6,9,12,15-octadecapentenoylcoa
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02288
notes: FORMULA: C39H56N7O17P3S CHARGE: -4

metaM thbpt c
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:15372
is: HMDB00027
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
name: 5,6,7,8-tetrahydrobiopterin
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

metaM 34dhpac c
has only substance units: false
constant: false
initial amount: NaN
name: 3,4-Dihydroxyphenylacetaldehyde
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03791
is: CHEBI:27978
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043

metaR ALOX52
name: Arachidonate 5-lipoxygenase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.34
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
fast: false
reversible: false

metaM adn m
type: Species
initial concentration: 1.0
is: HMDB00050
boundary condition: false
name: adenosine
is: CHEBI:16335
is: SBO:0000247
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
initial amount: NaN

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_ea308d96_40fb_4671_98d9_e2da6bdca9c4
is: SBO:0000252
name: _BE042354_1_m
is encoded by: hsa:BE042354
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9f8de869_4d66_48e8_8c9b_77261bb70ff6
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PPAP2B
is encoded by: hsa:8613
initial amount: NaN
is: O14495
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_65c047d1_e3fe_4fed_9bbb_1f8bb4026971
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: Q9NVE7
name: PANK4
is encoded by: hsa:55229
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_97d048fc_7fea_449c_925f_b99bf8ad4121
is encoded by: hsa:4710
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: NDUFB4
is: O95168
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR ITPtn
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: ITP nuclear transport
type: Reaction

metaR G14T8g
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

http://identifiers.org/biomodels.db/MODEL1310110048#_4dadfbe2_2590_4772_8d1d_69b102a9526f
is encoded by: hsa:873
name: CBR1
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: P16152
is: SBO:0000252
constant: false

metaR RE3004M
is: SBO:0000176
kinetic law: MODEL1310110048#
name: RE3004
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_2d0b6648_3b89_4ce8_81e3_4ff176f89e2f
name: GGT2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:728441
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR RE3568C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
name: RE3568

metaR r1650
is described by: ECO:0000000
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
modifier: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM man c
boundary condition: false
name: D-Mannose
is: C00159
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16024
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169

metaR r1877
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaR GGLUCT
reversible: false
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
reactant: MODEL1310110048#
name: gamma-glutamylcyclotransferase
is: SBO:0000185
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.2.4

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR ACACt2
product: MODEL1310110048#
is: SBO:0000185
fast: false
name: acetoacetate transport via proton symport
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reactant: MODEL1310110048#

metaR MGCHrm
kinetic law: MODEL1310110048#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.18
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110048#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a3eb5992_c001_4065_959c_6f6daa2b69a7
constant: false
name: SLCO1B1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10599
is: Q9Y6L6

metaM ala B m
is: HMDB00056
is: CHEBI:16958
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
has only substance units: false
name: beta-alanine
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaR r1919
reactant: MODEL1310110048#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is: SBO:0000185
reversible: false

metaR DHPM2
is described by: ECO:0000000
name: dihydropyrimidinase (dihydrothymine)
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
reversible: false
kinetic law: MODEL1310110048#

metaR FAOXC102m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_26548756_b149_4772_a00a_a9cbcaaee518
is: SBO:0000297
has part: P48736
is encoded by: hsa:10870
has part: Q9UBK5
has only substance units: false
is encoded by: hsa:5294
type: Species
initial concentration: NaN
name: HCST:PIK3CG
initial amount: NaN
constant: false
boundary condition: true

metaR GLYt7 211 r
type: Reaction
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
modifier: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
fast: false

metaM ahcys e
is: HMDB00939
constant: false
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00021
type: Species
is: SBO:0000247
initial amount: NaN
name: S-Adenosyl-L-homocysteine

http://identifiers.org/biomodels.db/MODEL1310110048#_46c02536_99d4_4704_ae5e_8fa6dd3aa4b1
is encoded by: hsa:223
type: Species
has only substance units: false
name: ALDH9A1
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P49189
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_7e75b810_c075_4f4b_b2b6_482bf442ba88
constant: false
has only substance units: false
name: AK2
is encoded by: hsa:204
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM 3hexdtetcoa m
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
name: 3,7,10,13-hexadecatetraenoylcoa
has only substance units: false
is: HMDB02288

metaM 20ahchsterol m
has only substance units: false
name: 20-hydroxycholesterol
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:1296
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
boundary condition: false
is: HMDB06283

metaM ksi pre34 g
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 34
is: C00130
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: HMDB00175
boundary condition: false

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:28325
name: (S)-Hydroxydecanoyl-CoA
type: Species
boundary condition: false
constant: false

metaR FTHFDH
type: Reaction
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.6 Confidence Level: 4 AUTHORS: PMID:2733692 NOTES:IT
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.6
reversible: false
is described by: ECO:0000269
name: formyltetrahydrofolate dehydrogenase
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM ca2 e
initial concentration: 1.0
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:29108
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8cf1b09c_d67e_42b2_bda4_1175bb84aa43
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79053
name: ALG8
constant: false
is: A6NDW6
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_e49e2039_2449_42b2_924f_330fcd449deb
has only substance units: false
is encoded by: hsa:3284
initial amount: NaN
is: P26439
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: HSD3B2

metaM atp m
is: CHEBI:57299
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00538
has only substance units: false
is: C00002
initial concentration: 1.0
constant: false
boundary condition: false
name: ATP(4-)

metaR r0539
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110048#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
modifier: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.34
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reversible: true

metaR AG13T6g
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110048#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_931ee00f_a33d_442a_af21_eec094dc2d83
is: P36969
constant: false
name: GPX4
is: SBO:0000252
type: Species
is encoded by: hsa:2879
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_0bace295_0f95_4f36_b4bc_1a5446ac0198
is: Q99884
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: SLC6A7
is encoded by: hsa:6534
type: Species

metaR DMHPTCRNte
name: 2,6 dimethylheptanoyl carnitine transport
fast: false
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_1cfb7770_147b_4ae1_bbf7_afe5b94a3bca
initial concentration: NaN
constant: false
name: ACOX3
boundary condition: true
is encoded by: hsa:8310
type: Species
is: SBO:0000252
initial amount: NaN
is: O15254
has only substance units: false

metaR NDP8
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.9
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
name: nucleoside-diphosphatase (dUDP)
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_712e53bf_2b93_4f47_9d74_bb2b7804b9ce
is: P19801
initial concentration: NaN
boundary condition: true
name: ABP1
constant: false
initial amount: NaN
is encoded by: hsa:26
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_47688991_4997_4345_a45b_ba771f99ad2a
constant: false
initial concentration: NaN
name: MTHFD1L
initial amount: NaN
is: B2RD24
type: Species
boundary condition: true
is encoded by: hsa:25902
is: SBO:0000252
has only substance units: false

metaR PPAm
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase
modifier: MODEL1310110048#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
fast: false

metaM c10dc x
boundary condition: false
is: HMDB04047
notes: FORMULA: C17H30NO6 CHARGE: -1
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: sebacoyl carnitine
is: C14143
type: Species

metaM 5forthf c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57456
name: 5-Formiminotetrahydrofolate
is: C00664
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
constant: false
boundary condition: false
is: HMDB01534
initial concentration: 1.0
type: Species

metaM HC00591 m
boundary condition: false
initial concentration: 1.0
name: 2-oxoglutaramate
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16769
type: Species
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaM xol7ah2al c
is: CHEBI:27428
is: SBO:0000247
has only substance units: false
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445

W3 CDTF: Thu Aug 30 13:29:55 BST 2012

metaR RE1526M
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110048#
name: RE1526
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110048#_79513e4c_32da_43df_b9f8_08051c1de020
name: SLC20A2
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:6575
is: B2RBR4
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaM ksi pre29 g
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 29
is: SBO:0000247
initial amount: NaN
is: CHEBI:28067

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
fast: false
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110048#
reversible: true
product: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_6e408812_774e_4aec_b372_96138966b9e4
is: Q15392
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: DHCR24
initial amount: NaN
is encoded by: hsa:1718
is: SBO:0000252

metaR ECOAH9m
fast: false
is: SBO:0000176
type: Reaction
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304
product: MODEL1310110048#
reactant: MODEL1310110048#

metaM nrvnc c
constant: false
initial concentration: 1.0
is: HMDB02368
has only substance units: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: CHEBI:32392
name: nervonate
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR FAOXC103C102m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaM 4abut m
is: CHEBI:16865
name: 4-Aminobutanoate
initial concentration: 1.0
has only substance units: false
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00112
is: SBO:0000247

metaM 56dura c
name: 5,6-dihydrouracil
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00076
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: CHEBI:15901
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaM 5oxpro c
name: 5-oxoprolinate
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57606
initial concentration: 1.0
is: HMDB00267
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9b04b254_7184_410e_96da_e5e26dd0c9d3
type: Species
name: GGH
boundary condition: true
is: Q92820
constant: false
is encoded by: hsa:8836
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM 5oxpro e
constant: false
type: Species
name: 5-oxoprolinate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: CHEBI:57606
is: HMDB00267
is: SBO:0000247

metaM glyc3p m
is: HMDB00126
constant: false
initial amount: NaN
name: Glycerol 3-phosphate
boundary condition: false
initial concentration: 1.0
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
is: CHEBI:57597
is: SBO:0000247
has only substance units: false

metaR GGH 5DHFl
is described by: ECO:0000000
modifier: MODEL1310110048#
product: MODEL1310110048#
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
is: SBO:0000176
reactant: MODEL1310110048#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_5ba53a05_02a7_48df_8e2f_ee1708af42aa
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:314
is: O75106
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: AOC2

http://identifiers.org/biomodels.db/MODEL1310110048#_90b1acda_5fba_4c13_ab96_725eb559d1de
name: _AI697028_1_m
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI697028
initial amount: NaN

metaM 4mop e
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00695
type: Species
has only substance units: false
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial concentration: 1.0

metaR UAGDP
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.23
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
name: UDP-N-acetylglucosamine diphosphorylase
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
modifier: MODEL1310110048#

metaM 3octdectecoa m
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 3,6,9,12-octadecatetraenoylcoa
constant: false
has only substance units: false
is: HMDB02288
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN

W3 CDTF: Thu Aug 30 13:29:55 BST 2012

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM ksii core2 pre1 g
notes: FORMULA: C33H53N3O23X CHARGE: -1
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:28067
type: Species
name: keratan sulfate II biosynthesis, precursor 1
initial concentration: 1.0

metaM udp n
name: UDP(3-)
is: HMDB00295
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58223

metaR PROD2m
reversible: false
name: Proline dehydrogenase (m)
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000254
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.99.8

metaR r0345
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is described by: ECO:0000000

metaR ACNAMtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110048#
is: SBO:0000185
name: N-acetylneuraminate nuclear import
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110048#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ef89ccf1_b5f7_401a_89b0_03fa91c944cf
is: SBO:0000252
type: Species
is: E7EML0
name: SLC4A8
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:9498
boundary condition: true
has only substance units: false

metaR TYRPHELAT2tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM biliverd c
is: CHEBI:57991
constant: false
is: HMDB01008
boundary condition: false
type: Species
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: biliverdin(2-)

metaM docohepcoa m
has only substance units: false
constant: false
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
is: HMDB02288
type: Species
initial concentration: 1.0
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR RE3421R
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
name: RE3421
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_206fbd30_7697_43b2_bc54_8cb8451ce34c
is: P16930
constant: false
has only substance units: false
name: FAH
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2184
type: Species
boundary condition: true

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM icit m
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
boundary condition: false
is: SBO:0000247
is: C00311
has only substance units: false
name: Isocitrate
initial amount: NaN
is: HMDB00193

metaR GLUPRT
reactant: MODEL1310110048#
name: glutamine phosphoribosyldiphosphate amidotransferase
kinetic law: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110048#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.14
reversible: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:

metaM cysam c
type: Species
name: cysteaminium
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:58029
initial amount: NaN
is: HMDB02991
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_d1611ef0_97a8_4fea_94c3_a6e8c34463bd
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: Q546Y9
name: AICDA
boundary condition: true
is encoded by: hsa:57379
type: Species
is: SBO:0000252

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_51b7f34e_d97c_4640_ab69_77abc511ce2e
is: B2RB13
boundary condition: true
is encoded by: hsa:23305
has only substance units: false
name: ACSL6
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_68ed6c31_e6db_468f_b1c5_2e4fed7b80b0
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P54819
name: AK2
constant: false
is encoded by: hsa:204
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_94370e69_2330_4491_9f16_6e05d37536b2
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: NDUFA8
boundary condition: true
is encoded by: hsa:4702
initial concentration: NaN
is: B1AM93

metaM nrvnc e
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
has only substance units: false
is: CHEBI:32392
is: SBO:0000247
name: nervonate
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02368
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_edd2fbc4_8f87_423f_9e60_6034a6d625ff
name: _AL038231_1_c
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AL038231
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM oagd3 hs g
is: C00329
name: 9-O-Acetylated GD3
initial concentration: 1.0
is: CHEBI:17315
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01514
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_927cc209_7400_45f0_86d1_819909070c94
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1337
constant: false
type: Species
boundary condition: true
has only substance units: false
is: P12074
name: COX6A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_f6648276_eda3_47d9_b6cc_c872d20f4b86
initial concentration: NaN
is encoded by: hsa:AI348006
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: _AI348006_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8804f1d9_1e0f_4e77_a1a8_201050ae97ce
is encoded by: hsa:10948
is: B4DUY1
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: STARD3
boundary condition: true

metaM fe2 e
is: C00023
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false
initial concentration: 1.0
is: CHEBI:29033
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: Fe2+
is: HMDB00692

metaR PE HSter
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
name: phosphatidylethanolamine scramblase
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM 3pg m
has only substance units: false
type: Species
is: CHEBI:58272
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: SBO:0000247
constant: false
is: HMDB00807
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM HC01434 x
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: SBO:0000247
initial amount: NaN
is: CHEBI:58931
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false

metaR 3HCO3 NAt
name: 3HCO3_NAt
product: MODEL1310110048#
is described by: ECO:0000134
reactant: MODEL1310110048#
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).

metaM 4mop c
type: Species
is: CHEBI:17865
initial amount: NaN
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
is: HMDB00695
constant: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial concentration: 1.0
has only substance units: false

metaR RE2269E
kinetic law: MODEL1310110048#
is: SBO:0000176
type: Reaction
fast: false
name: RE2269
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.4.21.39
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is described by: ECO:0000000

metaR BDHm
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.30
is: SBO:0000176
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
fast: false
is described by: ECO:0000269

metaR r2308
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_2c5072a4_4b6a_4384_b36a_f9b41f9de3a4
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:55350
has only substance units: false
is: SBO:0000252
name: VNN3
type: Species
boundary condition: true

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaM dolp L c
name: dolichyl phosphate(2-)
is: CHEBI:57683
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000304
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
kinetic law: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_891bd9be_1458_4393_b2da_5f349774a2e4
constant: false
initial amount: NaN
initial concentration: NaN
is: P47895
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:220
name: ALDH1A3

metaR RDH2a
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110048#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.105
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269
reactant: MODEL1310110048#
name: retinol dehydrogenase (9-cis,NADPH)
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT

metaM dhf m
name: dihydrofolate(2-)
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
is: CHEBI:57451
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: HMDB01056
has only substance units: false
initial concentration: 1.0

metaR PAPStg
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
fast: false
reversible: true
name: 3'-Phosphoadenylyl sufate Golgi transport

metaM dcholcoa c
initial amount: NaN
type: Species
constant: false
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
is: CHEBI:28701
is: HMDB06292
has only substance units: false

metaM 6thf e
name: hexaglutamyl folate (THF)
is: SBO:0000247
constant: false
type: Species
boundary condition: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/169691
initial concentration: 1.0

metaM pristcoa c
name: pristanoyl coa
constant: false
type: Species
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
boundary condition: false
initial concentration: 1.0
is: CHEBI:51341
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM paps g
initial amount: NaN
is: CHEBI:58339
constant: false
is: SBO:0000247
is: HMDB01134
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
boundary condition: false
type: Species

metaM m6masnC g
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: CHEBI:36033
type: Species
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02177

http://identifiers.org/biomodels.db/MODEL1310110048#_5be74a3b_8f96_489d_b393_4d449fa18d6d
is encoded by: hsa:441024
constant: false
initial amount: NaN
is: Q9H903
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: MTHFD2L
type: Species

metaR r0340
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#

metaR r1446
name: EC:1.3.3.6
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaR ACCOAtn
reversible: true
name: acetyl-CoA transport, nuclear
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM g3pc c
constant: false
name: sn-Glycero-3-phosphocholine
boundary condition: false
is: HMDB00086
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
is: CHEBI:16870

http://identifiers.org/biomodels.db/MODEL1310110048#_988edd0c_2f3e_434a_a9ac_a6fc9da2de0c
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4537
name: ND3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P03897
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_028dc9fd_52ea_4d4d_9470_b4b769336c78
is: Q8NFF2
has only substance units: false
name: SLC24A4
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:123041
type: Species

metaM ibcoa m
has only substance units: false
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
name: isobutyryl-CoA(4-)
is: HMDB01243
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57338

http://identifiers.org/biomodels.db/MODEL1310110048#_390168f0_6b77_4ede_b55b_868a6613b88c
boundary condition: true
name: PLA2G1B
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5319
constant: false
is: P04054
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_668695ff_b217_4ab9_ac31_67227ca528fc
boundary condition: true
type: Species
name: CMA1
constant: false
is: Q4FEB3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1215
has only substance units: false
initial concentration: NaN

metaM dhf l
initial concentration: 1.0
is: HMDB01056
name: dihydrofolate(2-)
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:57451
boundary condition: false

metaR HSD17B9r
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
name: 17-beta-hydroxysteroid dehydrogenase (type 7)
notes: GENE_ASSOCIATION: (51478.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES:see PMID: 14643063 inferred use of O2 for oxidation - biochemical details have not yet been experimentally elucidated NJ
is version of: http://identifiers.org/ec-code/1.1.1.62
reversible: false
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000304
reactant: MODEL1310110048#

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR RETNt
kinetic law: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reversible: true
product: MODEL1310110048#
name: retinoic acid transport
reactant: MODEL1310110048#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_f5b2637f_4961_4f9c_bfdd_ad8b6336d725
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:T83654
name: _T83654_1_c
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_231dba9c_26e2_4984_b0d6_bbb366e7bb79
initial concentration: NaN
is encoded by: hsa:7001
name: PRDX2
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: P32119
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b69af960_45e0_476b_b503_4697607f06dc
is encoded by: hsa:3030
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: HADHA
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: E9KL44

http://identifiers.org/biomodels.db/MODEL1310110048#_3bd11d6e_3c77_46a2_9fcd_ea34ad6ab50b
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4129
initial amount: NaN
name: MAOB
initial concentration: NaN
is: P27338
boundary condition: true

metaM fe2 c
is: SBO:0000247
type: Species
is: C00023
initial concentration: 1.0
has only substance units: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
boundary condition: false
name: Fe2+
is: CHEBI:29033
initial amount: NaN
is: HMDB00692
constant: false

metaM mmcoa R m
boundary condition: false
is: HMDB01269
type: Species
constant: false
is: CHEBI:57326
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
initial amount: NaN
name: (R)-methylmalonyl-CoA(5-)
has only substance units: false

metaM HC00718 c
initial concentration: 1.0
is: CHEBI:57781
name: N-methylethanolaminium phosphate(1-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
boundary condition: false
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_767ad2df_3164_4996_befc_ac38c20187c6
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM tdchola x
is: HMDB00951
constant: false
is: CHEBI:9407
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: taurochenodeoxycholate
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

http://identifiers.org/biomodels.db/MODEL1310110048#_3a876264_87c5_4d01_9c7c_623b3ae14ec5
boundary condition: true
constant: false
name: _PRO1933_1_m
type: Species
initial amount: NaN
is encoded by: hsa:PRO1933
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM cholate e
is: HMDB00619
is: CHEBI:29747
initial concentration: 1.0
type: Species
name: Cholate
initial amount: NaN
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
constant: false
is: SBO:0000247
has only substance units: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_64481c19_f0bb_49c5_a88f_01448dc87328
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4697
name: NDUFA4
type: Species
initial amount: NaN
is: O00483
initial concentration: NaN

metaR FMNAT
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
type: Reaction
modifier: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.7.2
is: SBO:0000176
is described by: ECO:0000134
name: FMN adenylyltransferase
fast: false

metaR GGH 5DHFe
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (5DHF), extracellular
reversible: false
is described by: ECO:0000000
product: MODEL1310110048#
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_19c6dfbe_88a6_463e_814d_d155a78c9a3d
name: ACOT8
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10005
initial amount: NaN
constant: false
is: O14734
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_854c11c6_0bf1_42d2_8d17_40cebc0b5971
is: SBO:0000252
has only substance units: false
type: Species
is: Q16795
initial amount: NaN
is encoded by: hsa:4704
initial concentration: NaN
constant: false
name: NDUFA9
boundary condition: true

metaM 44mzym r
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:18364
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial concentration: 1.0
name: 14-demethyllanosterol
is: HMDB01286
boundary condition: false
initial amount: NaN
constant: false

metaM adn c
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: HMDB00050
name: Adenosine
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C00212
constant: false
is: CHEBI:16335

http://identifiers.org/biomodels.db/MODEL1310110048#_4d78fb53_7e2d_492d_978f_d186e3578d31
is: SBO:0000252
is: P00915
initial concentration: NaN
boundary condition: true
is encoded by: hsa:759
has only substance units: false
constant: false
name: CA1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_1e33a25f_8ef1_4ad8_9a69_c3d5ca317200
is encoded by: hsa:54344
boundary condition: true
is encoded by: hsa:8818
initial amount: NaN
has only substance units: false
name: DPM3:DPM1:DPM2
is: SBO:0000297
type: Species
has part: Q9P2X0
constant: false
initial concentration: NaN

metaM ps hs m
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: ps_hs[m]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
initial concentration: 1.0
boundary condition: false

metaR r0531
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
modifier: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
fast: false
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_84a3ca00_f5eb_47c7_be45_89edcb874ca1
is: O43505
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: B3GNT1
is encoded by: hsa:11041
initial concentration: NaN
constant: false

metaR 4MOPt2im
reversible: false
kinetic law: MODEL1310110048#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_2573e7e0_5c70_404f_95a1_7b9ceb93e8a8
is encoded by: hsa:5052
initial concentration: NaN
constant: false
boundary condition: true
name: PRDX1
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR H2Oter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
name: H2O endoplasmic reticulum transport
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#

metaR SERt4
name: L-serine via sodium symport
reactant: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
product: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185

metaM for r
has only substance units: false
name: Formate
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
boundary condition: false
is: C00058
constant: false
initial concentration: 1.0
is: HMDB00142
initial amount: NaN
is: CHEBI:15740

http://identifiers.org/biomodels.db/MODEL1310110048#_d97606a0_ba2a_42d1_ba4a_46f5a13db4f7
is encoded by: hsa:6536
constant: false
type: Species
name: SLC6A9
is: B7Z3W8
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR KSII CORE4t
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core4) transport, golgi to extracellular
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_e0f069ff_de5c_4fc3_b42c_eebfcf5d543e
is: Q6ZMR3
has only substance units: false
boundary condition: true
is encoded by: hsa:160287
is: SBO:0000252
constant: false
name: LDHAL6A
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_e4fc07de_0ee2_46e5_a080_923c3e5da0ee
name: TALDO1
is: P37837
is encoded by: hsa:6888
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaM leu L c
is: CHEBI:15603
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
initial concentration: 1.0
is: HMDB00687
has only substance units: false
name: L-leucine
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM 6a2ohxnt x
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
name: 6-amino-2-oxohexanoic acid
is: HMDB12151
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:17534
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_ef9c2afa_104e_4bf9_a419_6d645dd9e3d1
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6569
constant: false
name: SLC34A1
has only substance units: false
initial amount: NaN
is: Q7Z725

metaM udp l
initial concentration: 1.0
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: UDP(3-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_3fd1d767_d9dd_4afa_8c03_0a31e809cb55
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: O95477
is encoded by: hsa:19
name: ABCA1
boundary condition: true

metaM ditp n
is: CHEBI:61382
boundary condition: false
name: dITP(4-)
initial amount: NaN
is: HMDB03537
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM hista e
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial amount: NaN
type: Species
boundary condition: false
name: histamium
has only substance units: false
is: CHEBI:58432
is: HMDB00870
is: SBO:0000247

metaM g3m8masn r
constant: false
initial amount: NaN
is: C05873
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
type: Species
notes: FORMULA: C88H147N2O70X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0

metaR r0497
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110048#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reactant: MODEL1310110048#
type: Reaction
fast: false
product: MODEL1310110048#
is: SBO:0000176
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39

metaR O2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
name: O2 transport, endoplasmic reticulum
kinetic law: MODEL1310110048#

metaM icit x
name: isocitrate(3-)
is: HMDB00193
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:16087
boundary condition: false

metaM adp r
initial concentration: 1.0
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
has only substance units: false
type: Species
name: ADP(3-)
is: CHEBI:456216
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaM srtn e
is: SBO:0000247
is: CHEBI:350546
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00259
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_e003a35d_ad0b_49f4_8713_7428638557a8
initial amount: NaN
boundary condition: true
is: Q9BY49
is encoded by: hsa:55825
initial concentration: NaN
name: PECR
has only substance units: false
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_19ba4ba4_8dba_4f0e_b971_2e8859cd172d
is: SBO:0000252
initial amount: NaN
name: ALDH4A1
is encoded by: hsa:8659
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P30038

metaR NH4tn
fast: false
kinetic law: MODEL1310110048#
name: ammonia nuclear transport
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is: SBO:0000185
product: MODEL1310110048#

metaM cholate c
boundary condition: false
initial amount: NaN
is: HMDB00619
has only substance units: false
is: CHEBI:29747
name: Cholate
is: SBO:0000247
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
constant: false
initial concentration: 1.0

metaM leu L e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
is: SBO:0000247
is: HMDB00687
is: CHEBI:15603
name: L-leucine

metaM atp c
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: HMDB00538
is: CHEBI:30616
initial concentration: 1.0
is: C00002
name: ATP(4-)

metaR r0975
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110048#
name: Facilitated diffusion
kinetic law: MODEL1310110048#
reversible: false
product: MODEL1310110048#
type: Reaction
fast: false

metaR r2392
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
reactant: MODEL1310110048#
type: Reaction

metaM paps c
initial amount: NaN
is: CHEBI:58339
initial concentration: 1.0
is: HMDB01134
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaR DURAD2
is version of: http://identifiers.org/ec-code/1.3.1.2
name: dihydrothymin dehydrogenase (NADP)
reversible: true
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269

metaR FACOAL140i
reversible: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
name: fatty-acid--CoA ligase (tetradecanoate)
type: Reaction
reactant: MODEL1310110048#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR

metaM Lcystin e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16283
type: Species
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
initial amount: NaN
name: L-cystine

metaM 4mop m
is: HMDB00695
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:17865
boundary condition: false
constant: false
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial concentration: 1.0

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM xol7aone r
boundary condition: false
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
initial amount: NaN
is: HMDB01993
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_2b722dad_350e_4aee_834c_0c137128cd88
initial concentration: NaN
is: Q8IXK2
type: Species
constant: false
is encoded by: hsa:79695
name: GALNT12
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r0974
kinetic law: MODEL1310110048#
reversible: true
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_e60ac93c_7907_4b9f_bf1f_043387c3a0a8
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC24A4
is encoded by: hsa:123041
has only substance units: false
boundary condition: true
initial amount: NaN

metaR FAOXC226C227m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR r0295
kinetic law: MODEL1310110048#
is described by: ECO:0000000
fast: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reversible: false
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#

metaR DGCHOLtx
name: bile acid intracellular transport
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false

metaM ps hs e
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:18303
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: phosphatidylserine
initial concentration: 1.0
constant: false
boundary condition: false

metaR PHCDm
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
fast: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110048#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110048#

metaR DMHPTCRNCPT2
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: 2,6 dimethylheptanoly CoA carnitine transferase
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#

metaR r2053
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction
reversible: false
product: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM udp e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: HMDB00295
name: UDP(3-)
is: SBO:0000247
boundary condition: false
is: CHEBI:58223

http://identifiers.org/biomodels.db/MODEL1310110048#_3a49ad51_d3a6_4ee6_a508_ab2681c3d4fa
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23761
has only substance units: false
is: Q9UG56
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: PISD

http://identifiers.org/biomodels.db/MODEL1310110048#_cbf9ebb2_91c6_47a7_8192_b598d9a28314
is: SBO:0000252
name: ACOT7
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: O00154
is encoded by: hsa:11332

http://identifiers.org/biomodels.db/MODEL1310110048#_5f9aa0a6_f549_4c5a_a96f_53f5829b68b1
is: SBO:0000252
name: AACS
has only substance units: false
is encoded by: hsa:65985
boundary condition: true
is: Q86V21
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_3c724312_29b1_47e3_b996_04ccf960cd5c
initial amount: NaN
is: SBO:0000252
name: ST3GAL3
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6487
has only substance units: false
boundary condition: true

metaR TTDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
fast: false
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110048#
name: tetradecanoate (transport)
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
type: Reaction

metaM 4hoxpacd c
is: SBO:0000247
boundary condition: false
constant: false
name: (4-hydroxyphenyl)acetaldehyde
has only substance units: false
is: HMDB03767
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
initial concentration: 1.0
is: CHEBI:15621
type: Species
initial amount: NaN

metaR BTNt4i
reversible: false
name: Biotin uptake (antiport)
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110048#_3176dc88_0e7e_4a58_8760_9ef45ffc5c3b
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR CYTK10n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110048#
name: cytidylate kinase (CMP,dGTP),nuclear
reversible: true
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_52a1f072_4df1_4459_af6a_4a4ed69b06de
is: SBO:0000252
is encoded by: hsa:53
initial concentration: NaN
constant: false
is: E9PCI1
has only substance units: false
type: Species
initial amount: NaN
name: ACP2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_8ffd94b5_33b0_4524_a53e_21d248bdad8d
name: ACSL1
is: P33121
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:2180

http://identifiers.org/biomodels.db/MODEL1310110048#_487ed656_26dd_43d6_ad70_88487c7fcb50
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: _AI620219_1_c
is encoded by: hsa:AI620219
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_03eb2152_d491_408d_826e_fa52a666a05b
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:1719
initial concentration: NaN
is: P00374
constant: false
name: DHFR

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaM glyc3p x
is: CHEBI:57597
is: SBO:0000247
name: Glycerol 3-phosphate
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
initial concentration: 1.0
constant: false
has only substance units: false
is: C00093

metaM hista c
is: HMDB00870
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
type: Species
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: histamium
is: CHEBI:58432

http://identifiers.org/biomodels.db/MODEL1310110048#_85d8bce7_8610_4131_9fa4_f93b87afbd45
boundary condition: true
is: P24310
name: COX7A1
is encoded by: hsa:1346
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaM 2docopencoa m
boundary condition: false
is: HMDB02288
name: 2,7,10,13,16-docosapentenoylcoa
is: SBO:0000247
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

metaR C4STMO2Pr
name: C-4 methyl sterol oxidase
kinetic law: MODEL1310110048#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
is: SBO:0000176

metaR LPASE
kinetic law: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.1.5
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
type: Reaction
name: lysophospholipase
reversible: false
modifier: MODEL1310110048#
fast: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_6e0a9d74_7afc_4481_b5c6_6858b11cafca
initial concentration: NaN
name: CPT1B
is encoded by: hsa:1375
has only substance units: false
initial amount: NaN
is: E9PCP2
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaR GRTTx
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
name: geranyltranstransferase
modifier: MODEL1310110048#
product: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.1

metaM core6 l
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
has only substance units: false
name: Core 6

metaR NH4tp
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110048#
name: ammonia peroxisomal transport
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#

metaR r0973
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: Facilitated diffusion

metaM amet c
is: HMDB01185
is: SBO:0000247
is: C00019
initial concentration: 1.0
name: S-Adenosyl-L-methionine
is: CHEBI:15414
has only substance units: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_69b52c15_c8a3_44c7_abe6_6a5e064f3ede
initial amount: NaN
is encoded by: hsa:2109
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ETFB

http://identifiers.org/biomodels.db/MODEL1310110048#_ae7b7dd4_db91_435a_adda_13816dfc781f
name: AMY1B
is encoded by: hsa:277
initial amount: NaN
initial concentration: NaN
is: P04745
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaM Lcystin c
name: L-cystine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaR INSTt2r
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
reactant: MODEL1310110048#
name: inositol transport in via proton symport

metaR r1090
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_c13bd6e4_b53c_4a88_87ad_020f5c1a3c09
initial amount: NaN
name: SLC6A14
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11254
is: Q9UN76
type: Species
constant: false

metaM gchola c
is: CHEBI:58235
initial concentration: 1.0
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB00138
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_efa9d496_1637_4d84_aa6d_313c55b07585
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: _AI373818_1_m
boundary condition: true
constant: false
is encoded by: hsa:AI373818
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_5fa0e8da_957c_425d_a5dd_23f36f728fbf
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: Q9UBM7
name: DHCR7
initial amount: NaN
is encoded by: hsa:1717
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_9cebf024_b980_4b58_ba2b_e1a66a810b0b
boundary condition: true
name: PGM3
constant: false
is encoded by: hsa:5238
initial concentration: NaN
is: B4DX94
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_2742dabe_0149_4acd_88bf_287be752bd9b
boundary condition: true
name: TPI1
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:7167
is: SBO:0000252
is: Q53HE2

http://identifiers.org/biomodels.db/MODEL1310110048#_67fc75ff_8c81_4568_a0d5_dd1b3ddd6645
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: PIK3CA:PIK3R2
has part: P42336
is encoded by: hsa:5290
initial amount: NaN
is encoded by: hsa:5296
has part: O00459
is: SBO:0000297
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_d3158002_3190_4bd6_8410_5c9417a140e3
has only substance units: false
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is: SBO:0000297
constant: false
is encoded by: hsa:51227
initial concentration: NaN
initial amount: NaN
type: Species

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR 3MOPte
reversible: true
fast: false
name: Transport of 3-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185

metaR PROIMINOtc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Proline by the apical IMINO amino acid transporters in kidney and intestine
type: Reaction

metaR ASNtN1
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_da305795_af0e_4ae9_aa33_15c4e2fbbc02
boundary condition: true
constant: false
is encoded by: hsa:5091
has only substance units: false
is: P11498
name: PC
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaR PIter
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
type: Reaction
fast: false
product: MODEL1310110048#
is described by: ECO:0000212
is: SBO:0000185
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
name: phosphate transport, endoplasmic reticulum

metaM 10fthf5glu e
initial amount: NaN
is: HMDB00108
type: Species
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: SBO:0000247
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](5)
constant: false
initial concentration: 1.0
is: CHEBI:16236
boundary condition: false

metaR DMHPTCRNt
name: 2,6 dimethylheptanoyl crn transport
product: MODEL1310110048#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ

metaR MI1345PP
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110048#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
product: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.3.56
fast: false
is: SBO:0000176
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
is described by: ECO:0000269

metaM ade e
initial concentration: 1.0
name: adenine
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
constant: false
boundary condition: false
is: CHEBI:16708
is: SBO:0000247
is: HMDB00034
type: Species

metaM 1pipdn2c x
initial amount: NaN
name: 1-piperideine-2-carboxylate
constant: false
boundary condition: false
is: HMDB01084
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
has only substance units: false
type: Species
is: CHEBI:16187
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_1515dc9f_7893_4af8_a131_18850b07418b
boundary condition: true
initial concentration: NaN
name: SLC27A5
initial amount: NaN
type: Species
is encoded by: hsa:10998
is: SBO:0000252
constant: false
has only substance units: false
is: Q9Y2P5

http://identifiers.org/biomodels.db/MODEL1310110048#_10d51bcc_c4e4_4edd_80ae_0dc3838217d2
has only substance units: false
is encoded by: hsa:4126
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: MANBA
is: SBO:0000252
initial concentration: NaN
is: O00462

http://identifiers.org/biomodels.db/MODEL1310110048#_45d76302_fbf9_488a_a9f8_e25f5bde5be8
is encoded by: hsa:4731
is: SBO:0000252
name: NDUFV3
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: P56181
initial amount: NaN

metaR PPAt
kinetic law: MODEL1310110048#
name: Propionate transport, diffusion
product: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
type: Reaction
fast: false
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_4d49b467_bd95_410b_bcb7_1677cfa62246
name: PLCB2
has only substance units: false
initial amount: NaN
is: Q59F77
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:5330

metaM udp g
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
is: HMDB00295
is: CHEBI:58223
boundary condition: false
name: UDP(3-)

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_21c24e17_6c5a_4349_aeab_b6ab7604937c
initial concentration: NaN
is encoded by: hsa:LOC727762
constant: false
boundary condition: true
has only substance units: false
name: _LOC727762_1_m
is: SBO:0000252
type: Species
initial amount: NaN

metaR r1599
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_1cfb2909_90e5_410a_8e70_8f8379e27247
name: DGKA
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:1606
is: SBO:0000252
initial amount: NaN
is: P23743
initial concentration: NaN
type: Species

metaM oagd3 hs e
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
has only substance units: false
name: 9-O-Acetylated GD3
constant: false
boundary condition: false
is: HMDB02168
is: CHEBI:18421
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_22e7ac90_0978_45e2_87bf_452844ef04c7
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: Q8NCL4
boundary condition: true
is encoded by: hsa:11226
initial concentration: NaN
name: GALNT6

metaR r0642
is: SBO:0000176
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000

metaR HACD9m
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
type: Reaction
reactant: MODEL1310110048#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is described by: ECO:0000134
product: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
fast: false

metaR ADEt
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
reversible: true
is described by: ECO:0000269
fast: false
name: adenine reversible transport, cytosol
product: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110048#_ba0d26ef_b924_4241_9865_eb496105f8b9
initial amount: NaN
is: Q86VV3
has only substance units: false
name: ENTPD1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:953
constant: false
type: Species

metaR r2058
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
fast: false

metaM adp n
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
constant: false
initial amount: NaN
name: ADP(3-)
is: CHEBI:456216

metaR r1723
reversible: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_473039ba_5b9c_4a98_a47b_259347673a2d
is: Q5HYI4
is: SBO:0000252
name: SQLE
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6713
type: Species
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_33483b78_8529_4445_9075_a594178ca363
is: P14555
name: PLA2G2A
is: SBO:0000252
is encoded by: hsa:5320
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM 4abutn c
is: C00555
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
is: HMDB01080
boundary condition: false
name: 4-Aminobutanal
type: Species
is: CHEBI:58264
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_9713c069_88f3_4292_af65_9bf4717e6fee
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110048#_6f7e3ec8_b61c_4418_b7fb_5a4a18ea9f3c
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI935189
name: _AI935189_1_m
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_6dbfc879_bc2f_41e5_a3fe_8d92a561f62c
boundary condition: true
name: CA3
is: SBO:0000252
is: P07451
initial concentration: NaN
has only substance units: false
is encoded by: hsa:761
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_7c979cb0_3682_4211_a2c2_eb6a367860ae
name: _AV717590_1_m
is encoded by: hsa:AV717590
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_a204b60f_16b9_468d_a5d2_fc668d0194bd
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: _NM_013421_1_e
has only substance units: false
type: Species
is encoded by: hsa:NM 013421

metaR CYTK4n
fast: false
type: Reaction
modifier: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
name: cytidylate kinase (dCMP,GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_7b3bb3c2_d0cf_4e3c_9aff_00d97ad0eb84
type: Species
initial concentration: NaN
has only substance units: false
name: _H17063_1_c
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:H17063
boundary condition: true

metaR r1428
name: Free diffusion
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d166d95b_474e_4751_a385_6c39a61bd307
is: Q9GZX3
boundary condition: true
name: CHST6
is encoded by: hsa:4166
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR r1598
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110048#

metaR r0641
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110048#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reversible: true

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM didp n
boundary condition: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: dIDP
type: Species
is: HMDB03536
is: CHEBI:28823

metaM dhf c
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: 7,8-Dihydrofolate
is: HMDB01056
is: C00415
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57451
is: SBO:0000247
constant: false

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_efc81f67_cb6a_41ec_9da2_517ddd1d4799
initial amount: NaN
is encoded by: hsa:10050
boundary condition: true
type: Species
is: SBO:0000252
is: Q9Y2C5
name: SLC17A4
has only substance units: false
constant: false
initial concentration: NaN

metaR FACOAL191
kinetic law: MODEL1310110048#
fast: false
reversible: false
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#

metaR N2M2NMASNtly
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110048#
type: Reaction
name: n2m2nmasn transport, extracellular to lysosome

http://identifiers.org/biomodels.db/MODEL1310110048#_bbd79aef_f6ec_474c_a2ca_aed1e46c224e
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: Q7GXZ8
name: COX2
type: Species
boundary condition: true
is encoded by: hsa:4513

metaM adp m
is: C00008
is: HMDB01341
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3310
name: ADP
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:456216

http://identifiers.org/biomodels.db/MODEL1310110048#_c7afa06d_e346_4c8d_aa5d_d9ad3fdc14ec
boundary condition: true
name: SDHA
constant: false
is: SBO:0000252
is encoded by: hsa:6389
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: P31040

metaR UDPtl
fast: false
is: SBO:0000185
name: udp intracellular transport
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reversible: true
type: Reaction
product: MODEL1310110048#

metaR CLFORtex
reversible: false
modifier: MODEL1310110048#
name: chloride transport via formate countertransport
fast: false
is: SBO:0000185
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000304

metaM oagd3 hs c
constant: false
is: HMDB01514
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: CHEBI:17315
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00329
is: SBO:0000247
has only substance units: false
name: 9-O-Acetylated GD3
boundary condition: false

metaR r1396
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
name: EC:2.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
is: SBO:0000176

metaR FAEL183
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110048#
reversible: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

metaR M13N2Tg
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.101
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_bd1cef71_8965_4357_9115_26ce1841ddf6
initial amount: NaN
name: PIP4K2B
type: Species
is: SBO:0000252
constant: false
is: P78356
is encoded by: hsa:8396
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM srtn c
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00259
type: Species
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0
name: serotonin(1+)
boundary condition: false
is: SBO:0000247
is: CHEBI:350546

metaR r1597
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185

metaR r0644
fast: false
product: MODEL1310110048#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR CHATn
is version of: http://identifiers.org/ec-code/2.3.1.6
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000269
reversible: true
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
fast: false
is: SBO:0000176
name: Choline O-acetyltransferase
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_fbf92120_e29a_4b42_89ab_cdaff2aad1dc
type: Species
boundary condition: true
is: SBO:0000252
name: RRM2
initial concentration: NaN
is encoded by: hsa:6241
has only substance units: false
constant: false
is: P31350
initial amount: NaN

W3 CDTF: Thu Aug 30 13:29:55 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110048#_9686e981_2f9e_4904_ae7d_301f02d8c8e7
is encoded by: hsa:79717
initial amount: NaN
is: Q9HAB8
boundary condition: true
initial concentration: NaN
name: PPCS
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR LNELDCCRNt
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_30c2456a_2d91_4521_8356_ce38d0baf9cb
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: AMT
is: SBO:0000252
is encoded by: hsa:275
type: Species
is: P48728
initial amount: NaN

metaR LTA4H
is described by: ECO:0000134
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.3.2.6
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
reversible: false
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110048#
name: Leukotriene A-4 hydrolase

metaR P5CRxm
is: SBO:0000176
fast: false
modifier: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
name: pyrroline-5-carboxylate reductase (m)
is described by: ECO:0000304

metaR S6TASE25ly
type: Reaction
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is described by: ECO:0000000
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
name: galactose-6-sulfate sulfatase, lysosomal
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110048#

metaM CE2420 m
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB11123
is: CHEBI:28387
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
has only substance units: false

metaR r1397
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: carnitine acetyltransferase EC:2.3.1.7
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false

metaR DURItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
name: deoxyuridine transport in nucleus
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ebcdfcb9_9a85_4a14_9372_12272ec2786d
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: P05177
name: CYP1A2
boundary condition: true
constant: false
is encoded by: hsa:1544

MODEL1310110048
reaction: metaR r0400
species: metaM phaccoa c
reaction: metaR H6ET3er
species: metaM lnlncg l
reaction: metaR EX gchola LPAREN e RPAREN
species: metaM man6p c
reaction: metaR MECOALm
species: metaM fald c
species: metaM mescon m
reaction: metaR S6TASE25ly
reaction: metaR PUNP3
species: metaM 4abut e
species: metaM xoltriol c
reaction: metaR COAtm
species: metaM succ m
reaction: metaR r1621
reaction: metaR LEUKTRE4t
species: metaM HC01522 c
reaction: metaR CYTDt
species: metaM CE2432 m
reaction: metaR PHEACGLNt
reaction: metaR RE3245C
reaction: metaR 4MOPte
species: metaM g3p c
species: metaM cit e
reaction: metaR M8MASNterg
reaction: metaR r0732
species: metaM h x
species: metaM 5mta e
species: metaM g1m8masn r
species: metaM ksii core4 e
species: metaM Lcystin c
reaction: metaR FAOXC14C12m
species: metaM HC02208 e
reaction: metaR PGISr
reaction: metaR r1917
species: metaM nadh c
reaction: metaR HYXNt
reaction: metaR OCDCAtr
reaction: metaR 5OXPROt
species: metaM for c
reaction: metaR RE0830C
species: metaM HC02180 c
species: metaM pe hs c
species: metaM pi m
reaction: metaR CERT1rt
reaction: metaR r1749
species: metaM lgnc c
reaction: metaR r1590
reaction: metaR DURAD2
reaction: metaR r2375
species: metaM prostgi2 e
reaction: metaR ILEt5m
reaction: metaR r2132
species: metaM gdpfuc g
species: metaM 5mthf c
species: metaM thym c
reaction: metaR ASNSERNaEx
reaction: metaR URATEt
species: metaM dgtp n
reaction: metaR ADMDC
reaction: metaR PI4PLC
species: metaM ksi pre13 g
reaction: metaR ALAtN1
species: metaM 2mop m
reaction: metaR G14T2g
reaction: metaR VLCSp
reaction: metaR r1574
reaction: metaR CHOLESTle
reaction: metaR EHGLATm
species: metaM 3mob e
reaction: metaR ACGAM2E
reaction: metaR EX dttp LPAREN e RPAREN
reaction: metaR PIK3
species: metaM nadp c
species: metaM glc D e
reaction: metaR G14T18g
reaction: metaR TYROXDAc
reaction: metaR EX HC01361 LPAREN e RPAREN
reaction: metaR RE1518M

metaR r0074
product: MODEL1310110048#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
reversible: true
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12

metaR DHAPtc
is described by: ECO:0000134
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
name: transport of DHAP into cytosol
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: false
type: Reaction

metaM dhf e
name: dihydrofolate(2-)
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57451
has only substance units: false
is: HMDB01056

metaR r1596
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110048#
type: Reaction

metaR UMPK
reversible: true
name: UMP kinase
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110048#

metaR LCADi D
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110048#
name: lactaldehyde dehydrogenase
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110048#
type: Reaction
reversible: false
is described by: ECO:0000304

W3 CDTF: Thu Aug 30 13:29:55 BST 2012

metaM dolmanp L c
has only substance units: false
is: CHEBI:15809
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0

metaM gpi hs r
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
type: Species
is: CHEBI:16038

metaR r1429
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110048#_27ad5395_6f4f_4401_a84c_5d2aa8e4513b
type: Species
name: PKM2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5315

metaR SERASNNaEx
product: MODEL1310110048#
reversible: false
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110048#
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)

metaM udp c
boundary condition: false
constant: false
type: Species
is: CHEBI:58223
is: SBO:0000247
initial amount: NaN
name: UDP
has only substance units: false
is: C00015
initial concentration: 1.0
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR HACD1m
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
reactant: MODEL1310110048#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110048#_60ac99de_1ba0_47f0_8a21_ff6e6c177a1c
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC24A1
is: B4DUG1
type: Species
is encoded by: hsa:9187
constant: false
has only substance units: false

metaM ps hs c
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
initial amount: NaN
name: ps_hs[c]
is: CHEBI:18303
boundary condition: false
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_f7150023_0de7_4e63_97a7_5d2af46139ac
boundary condition: true
name: ALG3
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10195
has only substance units: false
initial concentration: NaN

metaR r1622
modifier: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR PEPCKm
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
name: Phosphoenolpyruvate carboxykinase (GTP)
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.1.1.32
reactant: MODEL1310110048#
product: MODEL1310110048#

metaM no c
name: Nitric oxide
constant: false
is: SBO:0000247
is: HMDB03378
type: Species
initial concentration: 1.0
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: CHEBI:16480
initial amount: NaN
boundary condition: false
is: C00533
has only substance units: false

metaR ASNPHELAT2tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM dha e
constant: false
initial concentration: 1.0
type: Species
is: HMDB01882
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
boundary condition: false
name: glycerone
is: CHEBI:16016
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_f701ff6c_8ddf_4882_bf13_7478929e462f
is: Q53TV9
is encoded by: hsa:6120
constant: false
initial concentration: NaN
boundary condition: true
name: RPE
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

metaR ALASm
type: Reaction
reversible: false
name: 5-aminolevulinate synthase
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.3.1.29
is version of: http://identifiers.org/ec-code/2.3.1.37
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_feb070e2_93a7_4dc9_9317_46b8e6d65c39
is: SBO:0000252
name: PMVK
type: Species
is encoded by: hsa:10654
has only substance units: false
boundary condition: true
is: Q6FGV9
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8fbec41d_a6a1_40c1_a221_5ee040011872
constant: false
is: P22392
initial concentration: NaN
type: Species
is encoded by: hsa:4831
is: SBO:0000252
name: NME2
has only substance units: false
boundary condition: true
initial amount: NaN

metaR AG13T10g
product: MODEL1310110048#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_5b89535f_052d_4ea2_95f7_c0ec00dad25c
boundary condition: true
is: SBO:0000252
type: Species
name: SLC4A10
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:57282
initial concentration: NaN
is: B7Z1R0

metaM dcdp c
name: dCDP
is: CHEBI:58593
is: HMDB01245
type: Species
is: SBO:0000247
is: C00705
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR NDPK8n
reversible: true
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR 4HPRO LTte
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
type: Reaction
name: Transport of trans-4-hydroxy-L-proline
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000134

metaM h2o x
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
is: CHEBI:15377
is: C00001
initial amount: NaN
name: H2O
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false

metaM cl c
is: HMDB00492
constant: false
has only substance units: false
is: C00115
boundary condition: false
is: CHEBI:3966
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
name: Chloride
is: SBO:0000247
type: Species

metaR r2320
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
fast: false

metaR r1621
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110048#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
fast: false

metaR NADtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
name: NAD transporter, endoplasmic reticulum
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_28533ed2_e2ce_45f7_aa35_9f501a610fe5
is encoded by: hsa:2182
constant: false
has only substance units: false
boundary condition: true
is: Q5JWV8
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ACSL4

http://identifiers.org/biomodels.db/MODEL1310110048#_03bfcbf5_80e0_4817_bfa2_352201193d84
has part: P23434
is: SBO:0000297
type: Species
is encoded by: hsa:275
constant: false
has only substance units: false
is encoded by: hsa:2653
has part: P48728
has part: P23378
initial amount: NaN
is encoded by: hsa:2731
boundary condition: true
initial concentration: NaN
name: DLD:GCSH:GLDC:AMT

http://identifiers.org/biomodels.db/MODEL1310110048#_e75f6571_3897_42d9_bfc5_5cb54694b23a
is: Q8TF71
is encoded by: hsa:117247
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: SLC16A10
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_0bd8801a_5257_46d1_911b_afb84d9c7dc2
constant: false
is encoded by: hsa:6531
is: SBO:0000252
initial amount: NaN
is: Q01959
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: SLC6A3

metaM hxan e
initial concentration: 1.0
is: CHEBI:17368
initial amount: NaN
is: HMDB00157
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: hypoxanthine
has only substance units: false
constant: false
type: Species
boundary condition: false
is: SBO:0000247

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_d26aaf61_cf83_4238_8ec3_19c8e429a6da
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2181
initial concentration: NaN
name: ACSL3
type: Species
constant: false
is: O95573
has only substance units: false

metaR RE1709N
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false
name: RE1709

metaM HC02204 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-b1
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:27624

metaM HC01007 x
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:18102
type: Species
name: L-Octanoylcarnitine
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR ASPDxt
product: MODEL1310110048#
name: D-aspartate transport, peroxisomal
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reversible: true
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000

metaR THFtm
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
product: MODEL1310110048#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR LPCOXp
type: Reaction
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.3.1
is described by: ECO:0000269
fast: false
reactant: MODEL1310110048#
is: SBO:0000176
name: L-pipecolate oxidase, peroxisomal
reversible: false
modifier: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_48ac005c_fe84_4c2d_ab85_0ed2db68f8a5
name: SLC17A2
is: O00624
is encoded by: hsa:10246
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaM CE5117 m
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial concentration: 1.0
is: CHEBI:57923
constant: false
initial amount: NaN
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR ACGPID
name: N-acetylglucosaminylphosphatidylinositol deacetylase
modifier: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.89

metaR ATPtm
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ADP/ATP transporter, mitochondrial
kinetic law: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#

metaR r2321
product: MODEL1310110048#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#

metaR r0801
fast: false
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR MALSO3tm
is described by: ECO:0000269
product: MODEL1310110048#
fast: false
type: Reaction
modifier: MODEL1310110048#
name: Malate:sulfite antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
is: SBO:0000185

metaR r0021
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reactant: MODEL1310110048#

metaM 2hexdtricoa m
name: 2,7,10-hexadecatrienoylcoa
has only substance units: false
is: HMDB02288
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaM ipdp c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
name: Isopentenyl diphosphate
is: C00129
is: CHEBI:128769
constant: false
is: HMDB01347
is: SBO:0000247
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129

metaR PLA2 2
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
is version of: http://identifiers.org/ec-code/3.1.1.4
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
reversible: false
name: phospholipase A2
is described by: ECO:0000000
fast: false
modifier: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#

metaM no e
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB03378
name: Nitric oxide
type: Species
is: CHEBI:16480
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
boundary condition: false

metaR PRO1xm
reversible: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000254
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110048#
name: proline oxidase (NAD), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110048#_69def7f6_946f_4b9a_95e8_d64dcb020f94
is encoded by: hsa:4698
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: NDUFA5
is: Q16718

metaR PHACCOAGLNAC
kinetic law: MODEL1310110048#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
product: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
type: Reaction

metaM dhap x
constant: false
initial concentration: 1.0
is: C00111
has only substance units: false
is: HMDB01473
name: Dihydroxyacetone phosphate
is: CHEBI:57642
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411

metaM 4ppan c
initial concentration: 1.0
constant: false
is: C03492
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:10986
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
has only substance units: false
name: D-4'-Phosphopantothenate
is: HMDB01016
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_04aaf8eb_8607_4718_8c98_82ab519ea7de
boundary condition: true
is: SBO:0000252
is: Q5SYN6
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC22A3
has only substance units: false
constant: false
is encoded by: hsa:6581

metaR r1590
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110048#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction

metaM so4 l
name: sulfate
type: Species
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16189
is: HMDB01448

metaR HISCAT1
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a3d35464_a55c_49c9_bebf_e98729cba4ce
type: Species
initial amount: NaN
is: Q16720
name: ATP2B3
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:492
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9c463827_d7c9_40e0_855c_ce247de19678
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:7378
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: UPP1

metaM crn x
is: C00318
constant: false
has only substance units: false
is: HMDB00062
type: Species
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: L-Carnitine

metaR FAOXC123m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_1a8e80dd_a5f5_47d3_9425_582f947eb839
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ALG12
is: Q9BV10
is encoded by: hsa:79087
type: Species

metaR r1624
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM gthox c
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00127
is: HMDB03337
is: CHEBI:58297
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
name: Oxidized glutathione

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR Q10H2e
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
name: transport of ubiquinol into lymph
reversible: true
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

metaR r0022
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_14d2b235_cac3_4b9b_b2f5_abdd6691af2c
is encoded by: hsa:11046
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: SLC35D2
is: Q76EJ3
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_4d2f0b7e_a0b3_48ed_b709_ac2a82f12f0e
is: P16278
type: Species
has only substance units: false
name: GLB1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:2720
initial amount: NaN

metaM 4hpro LT m
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:18095
boundary condition: false
constant: false
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
initial concentration: 1.0
name: trans-4-hydroxy-L-proline

metaM xol7aone m
initial amount: NaN
boundary condition: false
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
is: HMDB01993
initial concentration: 1.0
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
type: Species

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_18521de2_9986_4230_8c1c_f752f1fea234
boundary condition: true
name: PIK3C2G
constant: false
is encoded by: hsa:5288
is: SBO:0000252
initial amount: NaN
is: O75747
type: Species
has only substance units: false
initial concentration: NaN

metaR FUMAC
name: fumarylacetoacetase
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.7.1.2
kinetic law: MODEL1310110048#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
reversible: false

metaR HIBDm
is: SBO:0000176
product: MODEL1310110048#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.31
fast: false
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is described by: ECO:0000269
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction

metaM HC02204 c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:27624
constant: false
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
type: Species

metaR r1591
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
type: Reaction
fast: false
product: MODEL1310110048#

metaM od2coa c
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
name: trans-Octadec-2-enoyl-CoA
initial concentration: 1.0
is: SBO:0000247
is: HMDB06529
is: C16218
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:50570

metaM ksi pre24 g
boundary condition: false
constant: false
is: C00130
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 24

http://identifiers.org/biomodels.db/MODEL1310110048#_b767185a_e3b8_4038_ab8e_2d4aef9f0ac3
name: TRNT1
type: Species
is: Q96Q11
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:51095
initial concentration: NaN

metaR FAOXC122C101m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_95fbe02e_4e9f_4134_9316_e35a31eb4011
constant: false
is: SBO:0000252
name: ACOT2
initial amount: NaN
is: P49753
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:10965
initial concentration: NaN

metaR FAOXC102C103m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_64494e8a_ad02_4df8_81d2_56f9dea878a8
initial concentration: NaN
is: O75746
name: SLC25A12
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:8604

metaM ksi pre22 g
is: HMDB00175
is: CHEBI:58053
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
name: keratan sulfate I biosynthesis, precursor 22
has only substance units: false
type: Species
is: C00130

metaM dpcoa m
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
is: CHEBI:57328
constant: false
type: Species
boundary condition: false
initial amount: NaN

metaM dolp L r
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false
name: dolichyl phosphate(2-)
is: SBO:0000247
is: CHEBI:57683
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR r1592
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_e284f4fc_cd1c_4e3b_a2b2_203412d97857
constant: false
name: GALE
initial amount: NaN
is encoded by: hsa:2582
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q38G75
initial concentration: NaN

metaR 34DHPLACOX
modifier: MODEL1310110048#
is described by: ECO:0000269
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000176
reversible: false
type: Reaction

metaR FAOXC225m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a854fda9_c18b_4aff_9b3d_bee3613dd2fd
initial concentration: NaN
constant: false
name: SLC22A5
is encoded by: hsa:6584
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: O76082
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_d8b159b9_c774_4aa8_9c88_987ff2638c56
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: HADH
type: Species
has only substance units: false
constant: false
is: Q16836
is encoded by: hsa:3033
boundary condition: true

metaM oh1 c
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01039
constant: false
is: C01328
type: Species
has only substance units: false

metaR FAOXC142C122m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM 3mob e
is: CHEBI:11851
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00019
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
name: 3-methyl-2-oxobutanoate

http://identifiers.org/biomodels.db/MODEL1310110048#_7addfc8f_69ce_4ae2_8519_269ba4bad0d6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:27068
name: PPA2
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
is: Q9H2U2

metaM crn r
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
initial amount: NaN
is: CHEBI:16347
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: (R)-carnitine
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110048#_206fe1dc_5e6c_457d_9f6e_b1a9c7aae889
is: Q10472
is encoded by: hsa:2589
is: SBO:0000252
name: GALNT1
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaR OAGD3te
is described by: ECO:0000000
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
type: Reaction
is: SBO:0000185
reversible: true
name: oagd3 hs transport
fast: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR DOLGLCP Uter
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_e304868e_d520_4e4c_a5d3_e13304f0a414
name: PIGM
is: SBO:0000252
constant: false
is: Q9H3S5
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:93183

metaM dcsptn1coa x
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0
boundary condition: false
is: HMDB06513
is: C16173
constant: false
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_42e6f76d_9b35_4c15_91f1_171141184e5b
has only substance units: false
is encoded by: hsa:6520
has part: P08195
is: SBO:0000297
is encoded by: hsa:56301
initial concentration: NaN
has part: Q9NS82
constant: false
name: SLC7A10:SLC3A2
initial amount: NaN
boundary condition: true
type: Species

metaR r1593
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
type: Reaction
fast: false
is: SBO:0000185

metaR ALADGLNexR
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110048#
name: L-alanine/glutamine reversible exchange
reversible: true
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000304

metaR NDPK10
fast: false
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110048#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dIDP)
reactant: MODEL1310110048#

metaR COt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: CO transporter via diffusion
product: MODEL1310110048#

metaR NDPK9
reversible: true
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110048#
name: nucleoside-diphosphate kinase (ATP:IDP)
is: SBO:0000176
modifier: MODEL1310110048#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110048#_236266c2_9ac3_4a38_95b1_d9a47efe0711
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:158
type: Species
has only substance units: false
initial concentration: NaN
name: ADSL
is: SBO:0000252
is: P30566

metaR BILIRED
modifier: MODEL1310110048#
fast: false
product: MODEL1310110048#
name: Nad(p)h biliverdin reductase
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
is: SBO:0000176
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.1.24
type: Reaction
reversible: false

metaM vitd3 c
has only substance units: false
constant: false
is: CHEBI:28940
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
type: Species
initial concentration: 1.0
is: HMDB00876
boundary condition: false
is: SBO:0000247
name: calciol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_e671cf0a_812a_4cdf_b8c1_7dda0bc42909
boundary condition: true
type: Species
initial amount: NaN
name: HAO2
has only substance units: false
constant: false
is encoded by: hsa:51179
initial concentration: NaN
is: SBO:0000252

metaM CE2422 m
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
constant: false
is: HMDB11123
is: CHEBI:28387
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
has only substance units: false
is: SBO:0000247

metaM ksii core4 pre7 g
is: C00130
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
is: HMDB00175
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_15b55d1f_860b_4e60_b615_581354883c9e
boundary condition: true
is: P49914
has only substance units: false
is encoded by: hsa:10588
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: MTHFS

http://identifiers.org/biomodels.db/MODEL1310110048#_f2c5027b_c716_4a43_9fcf_72a4f133524c
has part: P15531
constant: false
name: NME1:NME2
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000297
has part: P22392
is encoded by: hsa:4831
is encoded by: hsa:4830
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_1d15f2a5_3920_4a7d_a7e6_ad9cc6ed579d
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: _AA526438_1_m
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:AA526438

metaM so4 m
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01448

metaR RE3524R
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110048#
name: RE3524
type: Reaction
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
kinetic law: MODEL1310110048#

metaM 5HPET c
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57450
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
name: 5(S)-HPETE(1-)
is: HMDB01193
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_0db70d37_9a4b_4359_8109_923a956d2d46
boundary condition: true
initial concentration: NaN
has only substance units: false
name: LDHB
is encoded by: hsa:3945
type: Species
constant: false
is: P07195
initial amount: NaN
is: SBO:0000252

metaR UMPK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
name: UMP kinase (dCTP),nuclear
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR P5CDm
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
fast: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4bd56fc7_9242_40c1_8e8c_daba018757cf
constant: false
is encoded by: hsa:10991
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC38A3
is: Q99624
initial concentration: NaN

metaR HCO3 CLt
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: bicarbonate transport (Cl-/HCO3- exchange)
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction
reversible: true
product: MODEL1310110048#
modifier: MODEL1310110048#

metaR NDPK8
is: SBO:0000176
kinetic law: MODEL1310110048#
name: Nucleoside-diphosphate kinase (ATP:dADP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110048#

metaM asp D e
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: HMDB06483
name: D-aspartate(1-)
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:29990

metaM m7masnC g
notes: FORMULA: C64H107N2O50X CHARGE: 0
constant: false
initial concentration: 1.0
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
is: HMDB02985
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:58433
boundary condition: false

metaR r2521
kinetic law: MODEL1310110048#
name: Utilized transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
reactant: MODEL1310110048#

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR UDPDOLPT L
is: SBO:0000176
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
fast: false
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.117
product: MODEL1310110048#
type: Reaction

metaM 3mob c
is: CHEBI:11851
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
constant: false
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
type: Species
is: HMDB00019

metaR r1594
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_37ddcf11_1007_4288_8256_9974808db2c3
type: Species
constant: false
name: _FLJ44968_1_m
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:FLJ44968

metaR DNDPt22m
fast: false
modifier: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
name: dTDP transport via dUDP antiport
product: MODEL1310110048#

metaR r1620
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#

metaM oh1 e
is: SBO:0000247
boundary condition: false
is: HMDB01039
initial concentration: 1.0
initial amount: NaN
type: Species
is: C01328
name: hydroxide ion
has only substance units: false
notes: FORMULA: HO CHARGE: -1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_1439fced_ae35_4b4c_9b28_20c2ce9533b4
boundary condition: true
is: O95864
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9415
name: FADS2

metaM phaccoa c
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
name: phenylacetyl-CoA(4-)
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: HMDB06503
is: CHEBI:57390
initial concentration: 1.0
has only substance units: false

metaR DAGKn hs
reversible: true
modifier: MODEL1310110048#
name: Diacylglycerol phosphate kinase (homo sapiens)
product: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.107
fast: false
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_abe7fdd0_f8c0_40e2_bc31_f742d3fbef03
is: Q9H2X9
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57468
constant: false
type: Species
initial amount: NaN
name: SLC12A5
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_55844bb2_3cd7_4c60_9c07_7c9fe0486e20
name: ATP10A
initial concentration: NaN
type: Species
is encoded by: hsa:57194
is: O60312
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_bbb9a915_ab21_439a_8d7f_7404f55ee605
is: SBO:0000252
name: _AV727634_1_c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AV727634
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaM HC01672 c
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
is: SBO:0000247
initial amount: NaN
is: CHEBI:37666
name: Acetyl adenylate
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_d8829b75_d252_4665_880e_e17ec5bbb95c
is: P49327
type: Species
initial concentration: NaN
is encoded by: hsa:2194
name: FASN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaR ACETONEt2
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110048#
reactant: MODEL1310110048#
name: acetone transport via proton symport
fast: false
modifier: MODEL1310110048#
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000185

metaM xu5p D c
boundary condition: false
initial concentration: 1.0
name: D-xylulose 5-phosphate(2-)
type: Species
is: HMDB00868
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
has only substance units: false
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110048#_b0e910cc_12fe_4062_9b66_ba5c4dc51e22
is: SBO:0000252
has only substance units: false
name: _AF116616_1_m
initial amount: NaN
is encoded by: hsa:AF116616
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaM ach n
name: acetylcholine
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15355
type: Species
has only substance units: false
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

http://identifiers.org/biomodels.db/MODEL1310110048#_96544c34_5dc2_46d4_9764_89bacca9bb10
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:3283
initial amount: NaN
constant: false
is: P14060
initial concentration: NaN
name: HSD3B1
boundary condition: true

metaR NDPK7
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
fast: false
reactant: MODEL1310110048#
name: nucleoside-diphosphate kinase (ATP:dCDP)
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176

metaM CE2416 x
constant: false
has only substance units: false
name: (2R,6S,10S)-pristanate
is: CHEBI:57923
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416

http://identifiers.org/biomodels.db/MODEL1310110048#_40763ad7_11cc_4d08_adb3_40fe3c264653
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ACHE
type: Species
is encoded by: hsa:43
is: P22303

metaR H8TAer
reversible: false
name: H8 transamidase, endoplasmic reticulum
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
modifier: MODEL1310110048#

metaM vitd3 e
is: HMDB00876
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:28940
type: Species
name: calciol
is: SBO:0000247

metaR OAGD3tg
is described by: ECO:0000000
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
kinetic law: MODEL1310110048#
name: oagd3 hs intracellular transport
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_20a99792_3476_412d_bad7_947d033716ed
has only substance units: false
is encoded by: hsa:6470
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: SHMT1
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_4962fb9b_5f5d_49d9_bc7c_a26dab3be524
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3633
name: INPP5B
constant: false
is: P32019
is: SBO:0000252

metaR r0892
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.2.27
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
product: MODEL1310110048#
name: Facilitated diffusion
is: SBO:0000185
reversible: true
modifier: MODEL1310110048#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d6e50459_e88f_4c26_afdf_25bcf70eb7ee
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4726
initial amount: NaN
name: NDUFS6
constant: false
is: Q6IBC4
boundary condition: true
type: Species

metaR r1595
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110048#_12acca8a_fb55_45b6_9079_eac38661c5eb
initial concentration: NaN
type: Species
is: P14555
name: PLA2G2A
is: SBO:0000252
is encoded by: hsa:5320
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d89eba3f_9d39_4e8c_a8b4_26eba5e196fa
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: _AA788780_1_c
constant: false
is encoded by: hsa:AA788780
boundary condition: true
is: SBO:0000252

metaM tym c
name: tyraminium
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:327995
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: HMDB00306
is: SBO:0000247

metaM occoa m
is: HMDB01070
type: Species
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
boundary condition: false
initial amount: NaN
is: CHEBI:57386
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

metaR RE0935E
fast: false
product: MODEL1310110048#
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_77bafb49_7ffb_4417_a040_d9cd8997e6b8
constant: false
has only substance units: false
is: P24311
initial concentration: NaN
name: COX7B
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1349
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_38f2c7bb_a2ca_4c75_aeaa_78ff57106100
constant: false
boundary condition: true
initial concentration: NaN
name: PIGC
type: Species
is encoded by: hsa:5279
is: Q92535
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4064e59f_5a41_4509_9f5c_b71f3462ac5b
initial amount: NaN
has only substance units: false
name: LTA4H
is: P09960
type: Species
boundary condition: true
is encoded by: hsa:4048
is: SBO:0000252
initial concentration: NaN
constant: false

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_100ed777_a43a_42e1_87eb_8bc4539d1367
constant: false
name: _AI222095_1_e
is encoded by: hsa:AI222095
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaM dd2coa m
has only substance units: false
initial amount: NaN
type: Species
name: trans-dodec-2-enoyl-CoA(4-)
is: CHEBI:57330
boundary condition: false
is: HMDB03712
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221

metaR BAAT2x
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
kinetic law: MODEL1310110048#
fast: false
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000269
is: SBO:0000176
name: bile acid Coenzyme A: amino acid N-acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110048#_85c25a6d_7c77_416a_80af_1885869e699f
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:230
name: ALDOC
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: P09972

metaM cholcoa x
type: Species
is: SBO:0000247
name: choloyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false
is: CHEBI:57373
boundary condition: false
is: HMDB01374
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_5c4350ea_fad6_402f_8c61_ca2bf1b231b1
is encoded by: hsa:23556
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O95427
type: Species
constant: false
name: PIGN

metaR r2101
reactant: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
fast: false

metaR TKT1
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
fast: false
name: transketolase
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
reactant: MODEL1310110048#

metaR C3STDH1Pr
fast: false
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)
type: Reaction
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
reversible: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.170
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_e3112c66_6b9f_4e94_8ac6_b63d5d535f57
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:200010
name: SLC5A9
initial concentration: NaN
boundary condition: true
is: E9PAK4
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_c7740b5f_2588_4d7e_9f2b_6c48d1ff73af
is encoded by: hsa:768
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q16790
name: CA9
initial concentration: NaN
constant: false
type: Species

metaR 3SALATAim
reversible: false
is described by: ECO:0000304
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR FAOXC164C143m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM CE2431 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
name: cis-deca-4-enoyl-CoA
constant: false
is: CHEBI:57795
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM crn m
initial amount: NaN
is: CHEBI:16347
has only substance units: false
is: HMDB00062
boundary condition: false
name: L-Carnitine
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
constant: false
is: C00318
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_efbb8fad_2281_4afd_a8a4_1b7de39e261c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: DEGS1
type: Species
is encoded by: hsa:8560

metaM asp D c
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: CHEBI:29990
constant: false
initial amount: NaN
name: D-aspartate(1-)
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB06483
initial concentration: 1.0

metaR HISTAtu
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000185
name: Histamine uniport
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110048#_e8732d8d_2fa3_45bb_a76d_827eb5bb86f1
type: Species
has only substance units: false
constant: false
is encoded by: hsa:23563
initial concentration: NaN
boundary condition: true
name: CHST5
is: SBO:0000252
initial amount: NaN

metaR GPIDAer
modifier: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD

metaR r2526
reversible: true
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_58a4b4c4_46ff_4556_8f6c_bb63bd85e192
is: O15245
name: SLC22A1
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6580
type: Species

metaR r2100
modifier: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR FORtr
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
name: FOR transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185

metaR r0527
is: SBO:0000176
product: MODEL1310110048#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reversible: true

metaR TKT2
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
name: transketolase
fast: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.2.1.1
reversible: true
is described by: ECO:0000000

metaR DNDPt33m
type: Reaction
fast: false
modifier: MODEL1310110048#
name: dGDP transport via dUDP antiport
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
is: SBO:0000185

metaR DCK2n
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.74
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
name: Deoxycytidine kinase, nuclear (UTP)
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000176
modifier: MODEL1310110048#

metaR PROSTGH2t
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
name: Prostaglandin H2 transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185
reversible: true
type: Reaction

metaR RE2625M
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110048#
name: RE2625
is described by: ECO:0000000
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#

metaM dcdp m
constant: false
name: dCDP(3-)
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01245
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_25569a37_00b2_4e34_844a_48284cba953e
constant: false
is encoded by: hsa:4122
type: Species
has only substance units: false
initial amount: NaN
name: MAN2A2
initial concentration: NaN
is: Q9P1E4
boundary condition: true
is: SBO:0000252

metaR S6T2g
product: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110048#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false

metaM bilglcur e
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
initial concentration: 1.0
name: mono(glucosyluronic acid)bilirubin(2-)

metaM succoa x
name: Succinyl-CoA
type: Species
initial amount: NaN
is: HMDB01022
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial concentration: 1.0

metaM HC01496 m
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:28095
initial amount: NaN
has only substance units: false
name: 2-Amino-3-oxoadipate
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_052d72e3_c228_4539_b440_6eeacbd681fa
type: Species
is: O00476
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: SLC17A3
is encoded by: hsa:10786
has only substance units: false
boundary condition: true

metaR ADK3m
name: adentylate kinase (GTP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110048#
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110048#

metaM dgpi prot hs r
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
is: SBO:0000247
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16004
initial amount: NaN
constant: false
type: Species
is: HMDB01311

http://identifiers.org/biomodels.db/MODEL1310110048#_585f5f54_dbc7_420d_a889_a3178aa2894e
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:54407
is: Q96QD8
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC38A2

http://identifiers.org/biomodels.db/MODEL1310110048#_fa63f9d2_4bed_405a_9b09_831ba1963e57
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6517
name: SLC2A4
initial concentration: NaN
is: P14672
has only substance units: false
constant: false

metaR DOLPH Uer
kinetic law: MODEL1310110048#
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reversible: false
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
reactant: MODEL1310110048#
type: Reaction

metaR ACACT1rm
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000176
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110048#
reversible: true
type: Reaction

metaM chtn e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17029
constant: false
has only substance units: false
name: chitin
type: Species
initial amount: NaN
is: HMDB03362
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
boundary condition: false

metaR r2103
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_391f5cce_a02d_4ea3_937f_472580c418df
name: AK5
is encoded by: hsa:26289
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaM h2o r
initial amount: NaN
is: HMDB02111
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
name: H2O
is: CHEBI:15377
initial concentration: 1.0
is: C00001

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaM udp r
initial concentration: 1.0
name: UDP
initial amount: NaN
is: C00015
type: Species
has only substance units: false
is: HMDB00295
is: SBO:0000247
is: CHEBI:58223
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b298ae7c_8f9b_48f0_a319_168a7ee68d54
constant: false
boundary condition: true
name: UCKL1
is encoded by: hsa:54963
initial amount: NaN
is: Q53HM1
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM ksii core2 deg6 l
is: SBO:0000247
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: HMDB00143
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 6
has only substance units: false
type: Species

metaR RE3003M
reactant: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3003
is: SBO:0000176
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_3277a732_d041_43ed_bee7_ec9c3677dbe3
constant: false
initial amount: NaN
type: Species
is: B2RDZ2
is encoded by: hsa:55312
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: RFK
has only substance units: false

metaR G14T7g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_df943274_ce1c_429f_bdf7_2dce451d5d0f
is: SBO:0000252
constant: false
is encoded by: hsa:2731
has only substance units: false
name: GLDC
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P23378

metaM dcdp n
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB01245
is: CHEBI:58593
boundary condition: false
name: dCDP(3-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaR ALAR
is described by: ECO:0000212
name: alanine racemase
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110048#
is: SBO:0000176
type: Reaction

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false

metaM gd3 hs g
is: SBO:0000247
initial amount: NaN
name: GD3
constant: false
is: CHEBI:28424
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
boundary condition: false
type: Species

metaM dpcoa e
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: C00882
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Dephospho-CoA
constant: false
is: HMDB01373
is: CHEBI:57328
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_3d5e1419_df29_45c4_a363_c49984619c51
constant: false
initial amount: NaN
is encoded by: hsa:8659
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ALDH4A1

metaM icit c
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false
is: HMDB00193
initial amount: NaN
type: Species
is: C00311
has only substance units: false
name: Isocitrate
constant: false
is: CHEBI:16087
initial concentration: 1.0
is: SBO:0000247

metaR r2102
product: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110048#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction

metaR TYROXDAc
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.4
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000269
product: MODEL1310110048#

metaM HC01162 c
boundary condition: false
type: Species
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: SBO:0000247
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58376

metaR DNDPt45m
modifier: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
type: Reaction
reversible: false
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
name: dTTP transport via ADP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110048#_1acc5f65_66df_4051_81fb_df04c7e395cb
type: Species
boundary condition: true
is encoded by: hsa:6785
initial amount: NaN
is: SBO:0000252
name: ELOVL4
has only substance units: false
constant: false
is: Q9GZR5
initial concentration: NaN

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM bilglcur c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
has only substance units: false
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_a78e0b3a_3fb4_4980_9270_1b9ca1bb7e8a
initial amount: NaN
constant: false
is: O43677
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: NDUFC1
is: SBO:0000252
is encoded by: hsa:4717

metaR RE2998M
type: Reaction
name: RE2998
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_f5953bc1_6c44_4a48_8b17_6b225f8d284f
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: GGT5
is encoded by: hsa:2687
is: P36269

metaR SPODMm
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
name: superoxide dismutase
reversible: false
fast: false
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000304

metaM HC01007 m
is: CHEBI:18102
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
has only substance units: false
name: L-Octanoylcarnitine
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_a9d3523a_dd62_4f74_93d6_d5afffd719e7
type: Species
is: SBO:0000252
is encoded by: hsa:1607
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: DGKB
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_7d46f1a8_d7a6_477a_9039_02f26a3f925e
name: MAN1A1
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P33908
is encoded by: hsa:4121
is: SBO:0000252
initial amount: NaN
type: Species

metaM xan c
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: C00385
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial concentration: 1.0
boundary condition: false
is: CHEBI:17712
name: Xanthine
is: HMDB00292

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR XOLDIOLONEt
name: lipid, flip-flop intracellular transport
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_5f62775f_5236_485b_b53e_52867959f708
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:763
name: CA5A
is: SBO:0000252
is: P35218
initial amount: NaN

metaR VD3
type: Reaction
name: Vitamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_88779367_1c53_429f_b3a8_e2c4445ce855
type: Species
is: Q8IWX5
is encoded by: hsa:130367
initial amount: NaN
boundary condition: true
has only substance units: false
name: SGPP2
is: SBO:0000252
initial concentration: NaN
constant: false

metaR SCPx
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.176
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
reversible: false
fast: false

metaM 10fthf c
type: Species
name: 10-Formyltetrahydrofolate
is: C00234
has only substance units: false
is: HMDB00972
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110048#_0ca7fc1e_15ff_4967_b296_ed38e441b630
is encoded by: hsa:2639
is: Q92947
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: GCDH

metaM dpcoa c
is: C00882
type: Species
is: CHEBI:57328
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01373
name: Dephospho-CoA
boundary condition: false
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247

metaR ATPtx
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
name: ATP transporter, peroxisomal
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_fda2ebcd_998f_4e2b_beda_e1ce1ff54cf9
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: Q6FGA0
name: COX7A2L
boundary condition: true
type: Species
is encoded by: hsa:9167
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_48c745aa_b5ef_4f66_97d8_7b1353a46675
boundary condition: true
initial amount: NaN
type: Species
name: AGXT2
has only substance units: false
is: Q9BYV1
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:64902

metaR RNDR1
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (ADP)
is described by: ECO:0000254
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#

metaR r1974
is described by: ECO:0000000
product: MODEL1310110048#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#
fast: false
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR 13DAMPPOX
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110048#
product: MODEL1310110048#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is: SBO:0000176
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_3ee4a522_5bdb_415b_afb7_de1d8be0c404
has only substance units: false
is encoded by: hsa:4731
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: NDUFV3
is: SBO:0000252
initial concentration: NaN

metaR GCC2cm
modifier: MODEL1310110048#
name: glycine-cleavage complex (lipoamide), mitochondrial
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
type: Reaction
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_92bceac6_d730_4ebb_8275_d57874de59a7
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110048#_7cd93f88_19b5_45a7_8864_0e87bfb624bb
initial concentration: NaN
has only substance units: false
name: C1GALT1
type: Species
is encoded by: hsa:56913
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: Q9NS00

http://identifiers.org/biomodels.db/MODEL1310110048#_d52a3e84_b949_418b_9f0a_888479e4863e
initial concentration: NaN
is encoded by: hsa:728441
is: SBO:0000252
boundary condition: true
name: GGT2
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR PCm
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
name: pyruvate carboxylase
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.4.1.1
fast: false
reversible: false
modifier: MODEL1310110048#
is: SBO:0000176

metaR RE1516M
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110048#
reversible: true
type: Reaction
is: SBO:0000176
name: RE1516
product: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_458b6a14_efa1_4999_a355_09ba065a2a96
is encoded by: hsa:6489
is: Q92185
name: ST8SIA1
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaM 3mob m
initial amount: NaN
type: Species
is: CHEBI:11851
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
boundary condition: false
constant: false
is: HMDB00019
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_40df5f75_ac45_418e_b85e_2579bff92ab0
is encoded by: hsa:7359
name: _7359_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaR r2193
type: Reaction
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
modifier: MODEL1310110048#
product: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
is described by: ECO:0000000

metaR APAT2rm
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
kinetic law: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000212
reversible: true
product: MODEL1310110048#

metaR PHEMEt
name: heme transport
modifier: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
is described by: ECO:0000269

metaM mercppyr c
is: CHEBI:57678
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: SBO:0000247
is: HMDB01368
constant: false
name: 3-mercaptopyruvate
type: Species
initial amount: NaN
has only substance units: false

metaR THCHOLSTOICtm
type: Reaction
reversible: true
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8ffcdb44_df26_49c0_910d_3ec70149b8b6
name: SLC4A5
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:57835
constant: false
is: Q9BY07

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM gluside hs r
initial amount: NaN
boundary condition: false
is: CHEBI:18368
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
constant: false
type: Species
name: D-glucosyl-N-acylsphingosine

metaR r1512
is described by: ECO:0000000
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000185
reversible: false

metaR DOLPMT3 Ler
product: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.260
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9ed5bd0d_747f_4ad4_b4bb_75f270052ce7
boundary condition: true
initial concentration: NaN
constant: false
name: _AA177072_1_c
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA177072

http://identifiers.org/biomodels.db/MODEL1310110048#_2b288977_c654_4a34_82d9_caaddaef7261
initial concentration: NaN
is: SBO:0000252
name: ST3GAL3
is: Q5T4W8
constant: false
is encoded by: hsa:6487
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaR RNDR4
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
name: ribonucleoside-diphosphate reductase (UDP)
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254

metaM cl e
type: Species
boundary condition: false
is: CHEBI:3966
is: SBO:0000247
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00115
is: HMDB00492
name: Chloride

metaM C05279 m
is: HMDB11123
has only substance units: false
type: Species
is: CHEBI:28387
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: trans,cis-Lauro-2,6-dienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110048#_c206e087_aeef_46d2_938f_c47ade1a25c0
initial amount: NaN
is: SBO:0000252
is: Q6ZWP6
boundary condition: true
type: Species
constant: false
has only substance units: false
name: ACAD8
is encoded by: hsa:27034
initial concentration: NaN

metaR FAOXC101m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR G14T12g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM val L m
type: Species
name: L-valine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
is: HMDB00883
constant: false
boundary condition: false
has only substance units: false

metaR CLHCO3tex2
product: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
kinetic law: MODEL1310110048#
name: chloride transport via bicarbonate countertransport (2:1)
reactant: MODEL1310110048#
reversible: false

metaR r0130
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110048#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_bcf2557c_c477_4582_ba9c_c5d713ed1870
constant: false
is encoded by: hsa:1719
boundary condition: true
has only substance units: false
name: DHFR
type: Species
is: SBO:0000252
is: P00374
initial concentration: NaN
initial amount: NaN

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_13a25d61_b0a5_4766_9529_d902e506213f
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:3422
is: SBO:0000252
boundary condition: true
name: IDI1
is: Q13907

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM lgt S c
initial amount: NaN
is: HMDB01066
name: (R)-S-lactoylglutathionate(1-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57474
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4b26f71c_599d_437e_b46d_707ca24e5302
constant: false
boundary condition: true
is encoded by: hsa:374907
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: B3GNT8
has only substance units: false

metaR RE1709C
name: RE1709
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110048#

metaR r2195
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_420e2e25_62e2_42f8_90fc_aa181ab5da2d
name: FUCA2
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q9BTY2
is: SBO:0000252
is encoded by: hsa:2519
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_741acc8f_3034_4981_8c8c_3fc09b19ee5a
is: A8K460
name: PLA2G6
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8398

metaR r0360
type: Reaction
product: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.16
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_994f072d_23a8_4450_a5be_8e7ed91f02fd
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: PGM2
initial concentration: NaN
has only substance units: false
is: Q96G03
is: SBO:0000252
is encoded by: hsa:55276

metaM clpn hs c
initial concentration: 1.0
name: clpn_hs[c]
is: CHEBI:15589
notes: FORMULA: CHARGE: 0
is: SBO:0000247
is: HMDB00156
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_20f6b694_7634_456d_8c6c_f103838c2c51
has only substance units: false
initial concentration: NaN
name: PANK2
constant: false
is: SBO:0000252
is encoded by: hsa:80025
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_71863b3b_614a_456c_95bb_947f141ba6e5
name: HADHB
is encoded by: hsa:3032
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P55084
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR PSDm hs
is described by: ECO:0000269
fast: false
reactant: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.65
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
name: Phosphatidylserine decarboxylase
product: MODEL1310110048#

metaM hxan c
is: C00262
boundary condition: false
initial concentration: 1.0
is: CHEBI:17368
initial amount: NaN
is: SBO:0000247
name: Hypoxanthine
constant: false
has only substance units: false
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: HMDB00157

http://identifiers.org/biomodels.db/MODEL1310110048#_d9f6c8a0_4efe_4dcd_8c4b_db02703969ff
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM acgam6p c
is: SBO:0000247
is: CHEBI:57513
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
type: Species
has only substance units: false
is: HMDB01062
boundary condition: false
name: N-acetyl-D-glucosamine 6-phosphate(2-)
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_2092ff5c_29e3_4665_afd9_1bcf2296be0f
has only substance units: false
is: Q6YFQ2
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: COX6B2
is encoded by: hsa:125965
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_44487abd_b053_4c67_a4cd_76f0cba4d519
is: O75355
name: ENTPD3
is encoded by: hsa:956
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM maltttr e
boundary condition: false
initial amount: NaN
has only substance units: false
name: Maltotetraose
is: http://identifiers.org/pubchem.compound/5141
is: C02052
type: Species
is: SBO:0000247
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: HMDB01296
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_d19f1a44_e03e_4b30_b93b_1955ba8656d4
is encoded by: hsa:1841
is: SBO:0000252
is: P23919
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: DTYMK
constant: false
type: Species

metaR RNDR2
reversible: false
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110048#
is described by: ECO:0000254
type: Reaction
name: ribonucleoside-diphosphate reductase (GDP)
kinetic law: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176

metaM sebacid x
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C08277
initial amount: NaN
is: HMDB00792
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
name: sebacicacid
has only substance units: false

metaR DOLPGT1 Uer
is: SBO:0000176
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
type: Reaction
is described by: ECO:0000000
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.267

metaR GARFT
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110048#
name: phosphoribosylglycinamide formyltransferase
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110048#
modifier: MODEL1310110048#

metaM s2l2n2m2masn e
is: HMDB00244
initial amount: NaN
is: SBO:0000247
is: C00255
name: de-Fuc form of PA6
initial concentration: 1.0
notes: FORMULA: C84H135N6O61X CHARGE: -2
type: Species
is: CHEBI:3554
has only substance units: false
boundary condition: false
constant: false

metaM ksi pre23 g
initial amount: NaN
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: SBO:0000247
is: CHEBI:28067
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 23
boundary condition: false

metaM 4hexdtetcoa m
is: HMDB02288
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 4,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
type: Species

metaR 2HBt2
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000269
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: 2-hydroxybutyrate cotransport with proton
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_1b447c37_8d73_4274_82f4_7a7312e44146
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:7084
initial concentration: NaN
name: TK2
is: SBO:0000252
type: Species
boundary condition: true
is: O00142

metaM nm4masn g
is: C05882
boundary condition: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C54H90N3O40X CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_131ee190_ab4e_4edb_bbe3_99a040ebd287
name: SLC6A9
type: Species
is encoded by: hsa:6536
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: P48067
initial concentration: NaN

metaR r2197
reversible: true
modifier: MODEL1310110048#
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000

metaR FATP2t
reactant: MODEL1310110048#
reversible: true
name: fatty acid electroneutral transport
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaM HC01409 m
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: CHEBI:27540
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
name: Hexanoyl-CoA

metaR CYSGLTH
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reactant: MODEL1310110048#
type: Reaction
fast: false
name: Glutathione:cystine oxidoreductase
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_7fa0e46c_7ef5_45ef_a729_9f9d6d9f0767
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: COX7C
constant: false
is: P15954
is encoded by: hsa:1350

http://identifiers.org/biomodels.db/MODEL1310110048#_cc36d49a_1462_4671_a584_aa30bc96188c
initial concentration: NaN
has part: A8K7W0
initial amount: NaN
type: Species
is: SBO:0000297
boundary condition: true
name: VNN3:VNN2:VNN1
has part: O95497
constant: false
is encoded by: hsa:55350
is encoded by: hsa:8876
has only substance units: false
is encoded by: hsa:8875

http://identifiers.org/biomodels.db/MODEL1310110048#_e19cdd44_c52d_43d8_9721_badc0d0cec0d
initial concentration: NaN
is encoded by: hsa:220
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: P47895
has only substance units: false
name: ALDH1A3
boundary condition: true

metaR RE1523M
is: SBO:0000176
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110048#
name: RE1523
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110048#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110048#_3f106bfb_d4bb_43c2_8a75_d756a74d1de8
name: MOGS
initial amount: NaN
has only substance units: false
type: Species
is: F5H6D0
initial concentration: NaN
is encoded by: hsa:7841
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_9a529d2b_1c79_4aba_a503_e89a904e35ae
initial amount: NaN
has only substance units: false
is: O95340
constant: false
is: SBO:0000252
is encoded by: hsa:9060
boundary condition: true
initial concentration: NaN
name: PAPSS2
type: Species

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_ebe1a629_490f_401b_a98a_bc510f9cee54
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:205
is: P27144
constant: false
initial amount: NaN
name: AK4
type: Species
boundary condition: true

metaM gluala e
is: http://identifiers.org/pubchem.compound/6503
is: C03740
has only substance units: false
name: 5-L-Glutamyl-L-alanine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB06248
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_6edcd063_bf6e_49f6_a8e7_e4e57001bbcd
is encoded by: hsa:218
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: ALDH3A1
initial amount: NaN
is: P30838
has only substance units: false
is: SBO:0000252

metaR CMPACNAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
name: CMP-Sia nuclear export
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110048#

metaR r2196
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#

metaM prostgf2 c
is: CHEBI:57404
has only substance units: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01139
initial concentration: 1.0
initial amount: NaN
name: prostaglandin F2alpha(1-)

metaR AG13T1g
modifier: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false

metaM pail4p hs n
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
boundary condition: false
constant: false
is: CHEBI:58178

metaM occoa x
boundary condition: false
is: HMDB01070
constant: false
initial concentration: 1.0
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
initial amount: NaN
has only substance units: false
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
is: SBO:0000247

metaR r1978
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000000
product: MODEL1310110048#

metaM dopa e
is: CHEBI:59905
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00073
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
has only substance units: false

metaR r0670
reversible: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000000
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176

metaM ficytC m
initial amount: NaN
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
boundary condition: false
type: Species
initial concentration: 1.0
name: Ferricytochrome c
is: SBO:0000247
constant: false
is: CHEBI:15991

http://identifiers.org/biomodels.db/MODEL1310110048#_8832fe08_9332_4f37_bd84_5a2f1f409abb
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10873
is: Q6TCH8
is: SBO:0000252
constant: false
initial amount: NaN
name: ME3
boundary condition: true

metaM 7dhchsterol r
type: Species
is: HMDB00032
is: CHEBI:17759
initial amount: NaN
is: SBO:0000247
name: cholesta-5,7-dien-3beta-ol
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_a87aeee6_815d_475e_9b9a_7681dac8e82c
name: ENTPD3
is: O75355
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:956

metaR MG1er
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.106
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
product: MODEL1310110048#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR CSNAT2x
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.137
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal

metaR CITL
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reversible: false
name: Citrate lyase
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_da72841d_cb17_4959_a42d_e19b1820538c
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O75610
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:10637
name: LEFTY1

metaR Htm
reversible: false
name: Uncoupling protein
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (9016.1) or (7352.2) or (7352.1) or (7351.1) or (9016.2) or (7350.1) or (9481.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR DCYTt
name: deoxycytidine transport via diffusion
reversible: true
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR r2199
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR AG13T9g
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR CREATt4 2 r
fast: false
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
name: Creatine transport (sodium symport) (2:1)

metaR r1977
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR OXAtp
product: MODEL1310110048#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reversible: false
name: oxalate transport out of peroxisome
is described by: ECO:0000000

metaR ORNTArm
kinetic law: MODEL1310110048#
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.13
is described by: ECO:0000269
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
name: ornithine transaminase reversible (m)
product: MODEL1310110048#

metaM ksi pre2 g
name: keratan sulfate I biosynthesis, precursor 2
constant: false
is: C00130
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_11e6ff23_eda9_42af_bc27_34628a7edb2f
initial concentration: NaN
name: PNPLA4
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:8228
constant: false
is: P41247
type: Species
has only substance units: false

metaR PROSTGE2t
fast: false
reactant: MODEL1310110048#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110048#
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR FAOXC164C165m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_d5544025_7961_4a47_aedd_2a0ac6534aa6
is: SBO:0000252
initial concentration: NaN
constant: false
name: SUCLG2
is encoded by: hsa:8801
initial amount: NaN
is: Q96I99
has only substance units: false
type: Species
boundary condition: true

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR SCP21cx
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR FUMSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfate antiport, mitochondrial
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_a6f47ae0_02f8_4cab_be50_558895cbaf8b
is: SBO:0000252
is encoded by: hsa:2806
name: GOT2
boundary condition: true
constant: false
is: P00505
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR r2198
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
fast: false

metaM ribflv e
is: C00255
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
name: Riboflavin
is: HMDB00244
constant: false
is: CHEBI:3554
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

metaM succoa m
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57292
is: HMDB01022
name: Succinyl-CoA
initial amount: NaN

metaR RE2426C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
type: Reaction
is described by: ECO:0000000
name: RE2426
product: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
reversible: true

metaM m3mpdol U c
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:37632
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM dolmanp U c
initial concentration: 1.0
is: CHEBI:15809
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: Dolichyl phosphate D-mannose, human uterine homolog

metaM focytC m
is: CHEBI:16928
initial concentration: 1.0
name: Ferrocytochrome C
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: SBO:0000247
constant: false

metaM dadp c
has only substance units: false
is: C00206
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
name: dADP
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r0523
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
fast: false
product: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
modifier: MODEL1310110048#
reactant: MODEL1310110048#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is described by: ECO:0000000
type: Reaction

metaM dgchol x
name: glycochenodeoxycholate
boundary condition: false
is: CHEBI:36252
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
is: HMDB00637
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_690a580b_9ed6_4074_a747_211386795f7a
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:223
name: ALDH9A1
is: P49189

metaR LALDO
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#

metaR r0354
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
type: Reaction
reversible: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110048#

metaM odecoa c
is: HMDB01322
is: SBO:0000247
constant: false
has only substance units: false
name: Octadecenoyl-CoA (n-C18:1CoA)
boundary condition: false
is: CHEBI:3793
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species

metaM Tn antigen g
initial amount: NaN
name: Tn antigen
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_c006ddca_b2d0_4c5b_ada9_ad7cf2817bf7
is encoded by: hsa:4842
constant: false
has only substance units: false
is: B4DG68
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NOS1

http://identifiers.org/biomodels.db/MODEL1310110048#_5919d068_b829_41b9_86ea_b0787e5e4094
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: Q9HC21
is encoded by: hsa:60386
name: SLC25A19
is: SBO:0000252
type: Species
has only substance units: false

metaM dhap m
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00111
is: HMDB01473
name: Dihydroxyacetone phosphate

metaR r1846
is: SBO:0000185
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#

metaR HMGCOASim
reversible: false
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
reactant: MODEL1310110048#
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.3.10
kinetic law: MODEL1310110048#

metaM HC02217 e
is: CHEBI:27647
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN

metaM lpchol hs c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: lysophosphatidylcholine
is: SBO:0000247
type: Species
constant: false
is: CHEBI:60479
boundary condition: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110048#_6ad54ff5_78c2_4bc3_9209_5306851db211
initial amount: NaN
type: Species
is encoded by: hsa:2618
name: GART
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q59HH3
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_c231969c_7b57_43b6_90a7_b801214cad48
constant: false
initial amount: NaN
is: Q6LEN6
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1103
name: CHAT
has only substance units: false

metaR Htg
is described by: ECO:0000000
is: SBO:0000185
name: proton diffusion (Golgi)
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#

metaR IZPN
type: Reaction
name: Imidazolonepropionase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false

metaM 3php c
name: 3-phosphonatooxypyruvate(3-)
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01024
constant: false
initial concentration: 1.0
is: CHEBI:18110

http://identifiers.org/biomodels.db/MODEL1310110048#_2b8857ed_c568_46a0_8f7c_b01f1cade3e7
constant: false
name: HPD
is encoded by: hsa:3242
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: B3KQ63
boundary condition: true
initial amount: NaN

metaR CYSGLUexR
reversible: true
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
name: L-cysteine/L-glutamine reversible exchanger
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000304
type: Reaction

metaR FAOXC61C4m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_652a8c82_bd54_4497_a9d2_3d24e0e3a476
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2739
has only substance units: false
type: Species
name: GLO1
initial amount: NaN
constant: false
is: SBO:0000252
is: Q04760

http://identifiers.org/biomodels.db/MODEL1310110048#_cee722de_0565_4430_94b0_639e05b3002b
is encoded by: hsa:7378
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: UPP1
is: Q16831
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_f33153d3_76de_4f3c_afbc_9239310fd58b
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI091231
name: _AI091231_1_c
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_623e103f_c56d_4132_be70_def6e62d3a77
boundary condition: true
is: SBO:0000252
is: P03915
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: ND5
is encoded by: hsa:4540
type: Species

metaR HMGCOARc
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110048#
fast: false
reversible: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reactant: MODEL1310110048#
type: Reaction

metaR FAOXC163Gm
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR r0522
modifier: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reversible: false
is: SBO:0000176
reactant: MODEL1310110048#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110048#
fast: false

metaR FAOXC185C164m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR r0355
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110048#
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaR r2047
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_e255b3e6_41ec_4b1a_a219_6a4b642daa56
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: O95497
is encoded by: hsa:8876
type: Species
name: VNN1
has only substance units: false
boundary condition: true
constant: false

metaR CYSt4
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
product: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
name: L-cysteine reversible transport via sodium symport
is: SBO:0000185
type: Reaction

metaM asp D x
constant: false
initial concentration: 1.0
is: CHEBI:29990
is: HMDB06483
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: D-aspartate(1-)
type: Species
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1

metaR DUMPtn
product: MODEL1310110048#
fast: false
is: SBO:0000185
type: Reaction
name: dUMP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_07507c95_7653_4e70_ae97_1f41f29327d6
is: Q9BZQ4
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: NMNAT2
constant: false
is: SBO:0000252
is encoded by: hsa:23057
type: Species

metaM eicostet c
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB02177
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1
name: eicosatetranoic acid
boundary condition: false
type: Species

metaM 4hpro LT c
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
type: Species
name: trans-4-hydroxy-L-proline
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:18095
is: HMDB00725
boundary condition: false
initial concentration: 1.0

metaM HC00319 c
initial amount: NaN
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:30794
boundary condition: false

metaR r1147
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_5f67d240_842d_4b1d_b7c6_4bb90b46f0ef
name: B3GNTL1
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:146712
initial concentration: NaN
is: Q67FW5

metaR DURIt
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: deoxyuridine transport via diffusion
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110048#

metaR SERDGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000304
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: D-Serine/Glycine reversible exchange
fast: false
type: Reaction
product: MODEL1310110048#
reversible: true

metaR r2319
reversible: true
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
product: MODEL1310110048#
fast: false

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a30be5a2_a0b4_4d11_8dba_3ff7d70d8704
has only substance units: false
is encoded by: hsa:4833
is: SBO:0000252
type: Species
is: O00746
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: NME4
constant: false

metaM ipdp x
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01347
is: CHEBI:128769
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: isopentenyl diphosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110048#_ed6978c1_e17e_4a9f_bd0f_0ae3bc96491e
type: Species
name: PKLR
is: SBO:0000252
constant: false
is: P30613
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5313

http://identifiers.org/biomodels.db/MODEL1310110048#_3128c867_4afb_4c0b_aa13_3fd6d1051bec
boundary condition: true
constant: false
is encoded by: hsa:7352
has only substance units: false
initial amount: NaN
type: Species
name: UCP3
initial concentration: NaN
is: SBO:0000252
is: P55916

http://identifiers.org/biomodels.db/MODEL1310110048#_8c5a0a7a_4d37_4fcd_94b3_dc24c9a1495d
constant: false
is: Q7GXY8
has only substance units: false
name: COX1
is encoded by: hsa:4512
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
reversible: false
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110048#
name: hydrolysis of cholesterol ester by cholesterol esterase
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_343e910b_f4c2_486e_8317_b8b3f952c94d
is encoded by: hsa:AI971036
initial amount: NaN
name: _AI971036_1_c
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaM malthx e
is: C01936
constant: false
is: SBO:0000247
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false
type: Species
name: Maltohexaose
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041

http://identifiers.org/biomodels.db/MODEL1310110048#_9c756016_fef8_4d0d_b378_378daad885d0
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8526
is: A1L4Q0
initial concentration: NaN
name: DGKE
constant: false

metaM lpchol hs e
constant: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:60479
has only substance units: false
name: lysophosphatidylcholine
type: Species
initial amount: NaN

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type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:11001
name: SLC27A2
initial concentration: NaN
has only substance units: false
is: O14975

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR GLNASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
fast: false
reversible: false
product: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#

metaM val L e
is: CHEBI:16414
has only substance units: false
type: Species
boundary condition: false
name: L-valine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
is: HMDB00883

http://identifiers.org/biomodels.db/MODEL1310110048#_9d3af909_a576_4503_8443_c4d7a1187f32
name: PIGF
has only substance units: false
is encoded by: hsa:5281
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: Q07326
is: SBO:0000252
boundary condition: true

metaR r2318
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR NADPtru
is: SBO:0000185
fast: false
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110048#
name: NADP transporter, endoplasmic reticulum
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_c3f5e82c_ed27_4ad4_b9d9_6f9191337ef9
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ACOT6
is encoded by: hsa:641372
constant: false
type: Species
is: Q3I5F7
initial amount: NaN
initial concentration: NaN

metaM alpam m
boundary condition: false
name: S-aminomethyldihydrolipoamide
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: SBO:0000247
initial concentration: 1.0
is: HMDB06239
has only substance units: false

metaR PAIL45P HStn
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reactant: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_244459bf_8c66_4146_9a60_0b9f33190556
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: O43181
name: NDUFS4
is encoded by: hsa:4724

http://identifiers.org/biomodels.db/MODEL1310110048#_b362493d_00b1_4d09_a176_1f2d2c37c0b2
has part: P22392
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:4830
is encoded by: hsa:4831
has part: P15531
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
name: NME1:NME2

http://identifiers.org/biomodels.db/MODEL1310110048#_34a3cfa1_cb06_450e_b75b_7c8295038e1f
type: Species
constant: false
boundary condition: true
name: _728226_1_m
is encoded by: hsa:728226
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_34c09d9d_a3e8_4219_8f37_045004eeff59
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q96CA6
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:30
name: ACAA1

http://identifiers.org/biomodels.db/MODEL1310110048#_5aef465a_74a4_45e8_a38c_30e1f52cd851
boundary condition: true
name: ST20
constant: false
is encoded by: hsa:400410
initial amount: NaN
has only substance units: false
is: Q9HBF5
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r1418
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000176
product: MODEL1310110048#
type: Reaction
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reactant: MODEL1310110048#

metaM HC02210 e
name: prostaglandin-d3
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
is: CHEBI:34939
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_b5d22886_f4e3_4587_aa20_8d5ebd9b2fd1
has only substance units: false
type: Species
constant: false
is: P42126
boundary condition: true
is encoded by: hsa:1632
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ECI1

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR r0129
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is described by: ECO:0000000

metaM Tn antigen l
notes: FORMULA: C8H14NO5X CHARGE: 0
is: C04383
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: Tn antigen
constant: false
is: SBO:0000247

metaR RETH
kinetic law: MODEL1310110048#
reversible: false
fast: false
name: retinyl ester hydrolase
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.3

http://identifiers.org/biomodels.db/MODEL1310110048#_fc7a9b6b_2d81_455b_99c9_202f7e26f8be
is encoded by: hsa:10797
name: MTHFD2
is: P13995
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR r1629
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_e939c456_d682_4730_b620_cd95e3db5845
name: SLCO1C1
type: Species
is: Q5JPA4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:53919
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_de0b3cba_769c_4f67_932e_6eeee2471bf0
name: NME2
initial amount: NaN
is encoded by: hsa:4831
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P22392
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_9d42b6ad_bfa8_492d_8d9c_62c94ab52300
has only substance units: false
is: SBO:0000252
type: Species
name: LDHD
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:197257

metaR PI345P3P
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.67
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
fast: false

metaR r1585
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110048#

metaR 34HPPte
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false

metaR r2317
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_23300398_2712_4fb6_b8b4_8b026dd1524c
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR ASCBt
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
name: L-ascorbate transport via facilitated diffusion

metaR r0463
fast: false
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#
is described by: ECO:0000000
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
type: Reaction

metaR NDPK5
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_f6491459_1238_4d5c_8f68_9f3c299831d2
initial amount: NaN
name: ALPPL2
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:251
is: P10696

http://identifiers.org/biomodels.db/MODEL1310110048#_a32ba7b1_191b_4e05_9f64_14f52bd8cea8
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PIGO
constant: false
is encoded by: hsa:84720
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_1dba60e2_37ab_4814_9097_453a501f3e13
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q8N3T1
is encoded by: hsa:117248
name: GALNTL2
initial amount: NaN
is: SBO:0000252

metaR r2043
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is: SBO:0000185

metaR FUCASE2e
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, extracellular
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
is: SBO:0000176
product: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a943a665_e423_4f29_8a19_fb7c485b66ea
type: Species
has only substance units: false
is: SBO:0000252
is: Q9UJ70
constant: false
boundary condition: true
initial amount: NaN
name: NAGK
initial concentration: NaN
is encoded by: hsa:55577

http://identifiers.org/biomodels.db/MODEL1310110048#_f12018d4_3575_4b26_80a2_3657f1216460
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:2821
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: GPI
is: P06744

metaR PHEt4
is described by: ECO:0000269
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
type: Reaction
name: L-phenylalanine transport in via sodium symport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_7dde8ddc_68d9_466b_8d33_fcc561305c0e
is encoded by: hsa:X63359
is: SBO:0000252
initial concentration: NaN
type: Species
name: _X63359_1_c
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaR r0679
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

metaM dolp U r
type: Species
constant: false
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57683
boundary condition: false
initial amount: NaN

metaR r2316
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110048#
fast: false

metaR r1584
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110048#

metaR RE3272N
type: Reaction
fast: false
name: RE3272
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reactant: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
reversible: true

metaM 4mzym int2 r
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: 4-Methylzymosterol intermediate 2
is: HMDB06838
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_e6ef417e_f70a_41bc_8818_b626589a4941
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: Q3KT79
boundary condition: true
is encoded by: hsa:23600
has only substance units: false
name: AMACR

metaR r0464
is described by: ECO:0000000
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
reversible: true

metaR THYMt
type: Reaction
name: thymine reversible transport via facilated diffusion
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

metaM val L c
name: L-valine
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
constant: false
boundary condition: false
is: HMDB00883
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_95431804_bbf9_430c_a853_ebc270d232f7
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:51109
has only substance units: false
is: B4DDW0
name: RDH11
initial concentration: NaN
constant: false

metaR NDPK6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dUDP)
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000269

metaM 34dhpha c
initial amount: NaN
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
initial concentration: 1.0
type: Species
name: (3,4-dihydroxyphenyl)acetate
constant: false
is: SBO:0000247
is: HMDB01336
boundary condition: false
has only substance units: false
is: CHEBI:17612

metaR HEX10
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#
name: hexokinase (D-glucosamine:ATP)
is described by: ECO:0000212
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
modifier: MODEL1310110048#
is: SBO:0000176
fast: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_17202f6f_0e38_4b86_9367_eaa5fbe09272
has only substance units: false
constant: false
name: SUCLA2
initial concentration: NaN
is encoded by: hsa:8803
type: Species
initial amount: NaN
is: E5KS60
boundary condition: true
is: SBO:0000252

metaM HC02210 c
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:34939
name: prostaglandin-d3
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_91b04bc9_08d7_4f18_89f3_358b07288711
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:56922
is: Q96RQ3
name: MCCC1

http://identifiers.org/biomodels.db/MODEL1310110048#_177ed617_27fb_428b_a804_5f075be16ad8
boundary condition: true
is: SBO:0000252
is: Q14749
name: GNMT
initial amount: NaN
has only substance units: false
is encoded by: hsa:27232
constant: false
initial concentration: NaN
type: Species

metaM gluside hs g
is: CHEBI:18368
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaR UMPK7n
name: UMP kinase (dGTP),nuclear
is described by: ECO:0000269
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110048#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110048#

metaM 5dpmev c
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
name: (R)-5-Diphosphomevalonate
is: HMDB01090
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247

metaR r2315
product: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110048#

metaM pail4p hs c
is: CHEBI:58178
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
boundary condition: false

metaM HC02217 c
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
initial amount: NaN
is: CHEBI:27647
name: prostaglandin-g2
is: SBO:0000247
boundary condition: false

metaM gdpddman c
boundary condition: false
type: Species
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
is: HMDB01346
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
initial amount: NaN
has only substance units: false
is: CHEBI:57964
constant: false

metaR HSD3A1r
is described by: ECO:0000269
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110048#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
modifier: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_162050d3_40b6_44b3_b4bd_251ae056994c
is encoded by: hsa:J03866
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: _J03866_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4759c9ed_7a1a_4a4e_9737_43f2a9cffa78
constant: false
is encoded by: hsa:1376
is: SBO:0000252
name: CPT2
is: P23786
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR r1587
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM hgentis c
is: HMDB00130
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16169
initial concentration: 1.0
name: homogentisate
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
initial amount: NaN
has only substance units: false

metaR MI1P Dtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110048#
name: inositol 1-phosphate nuclear transport (diffusion)
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
fast: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_cee7548d_4205_489f_a12c_29f750f182cd
is: SBO:0000252
is encoded by: hsa:1582
type: Species
name: CYP8B1
initial concentration: NaN
initial amount: NaN
constant: false
is: Q9UNU6
has only substance units: false
boundary condition: true

metaR SARDHm
reversible: false
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.1
is described by: ECO:0000269
modifier: MODEL1310110048#
name: Sarcosine dehydrogenase (m)
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#

metaM thp2c c
constant: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16987
has only substance units: false
type: Species
is: HMDB12130
initial amount: NaN
name: 1-piperideine-6-carboxylate
boundary condition: false

metaR NDPK3
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110048#
name: nucleoside-diphosphate kinase (ATP:CDP)
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000269

metaM octa c
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00482
constant: false
is: SBO:0000247
is: C06423
has only substance units: false
name: octanoate (n-C8:0)
type: Species
is: CHEBI:25646

metaM 4hpro LT e
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
name: trans-4-hydroxy-L-proline
has only substance units: false
type: Species
constant: false
is: HMDB00725
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM thf m
is: C00101
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: HMDB01846
is: SBO:0000247
is: CHEBI:57453
name: 5,6,7,8-Tetrahydrofolate
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
has only substance units: false

metaR MCCCrm
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reactant: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110048#
fast: false
name: methylcrotonoyl-CoA carboxylase, mitochondrial
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.4.1.4

metaM so4 c
name: sulfate
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
is: CHEBI:16189
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01448

metaM eicostet e
notes: FORMULA: C20H31O2 CHARGE: -1
type: Species
is: HMDB02177
has only substance units: false
is: CHEBI:36033
initial amount: NaN
boundary condition: false
constant: false
name: eicosatetranoic acid
is: SBO:0000247
initial concentration: 1.0

metaR r2314
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_78aadf93_e66e_4b09_90bc_a23afd07a4da
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _U52111_1_c
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:U52111

http://identifiers.org/biomodels.db/MODEL1310110048#_73680117_7144_4b96_92b7_9ed7442545a5
is: O15427
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9123
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: SLC16A3

metaM CE2838 e
initial amount: NaN
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
name: maltononaose
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110048#_473d63b4_2b96_4ad4_81fb_63a909004e20
type: Species
has only substance units: false
initial concentration: NaN
name: FH
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2271
is: P07954

metaR r1586
product: MODEL1310110048#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_c38a861a_544b_4a2d_ad8e_d706dd126727
name: ACPP
is encoded by: hsa:55
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: P15309
initial amount: NaN
boundary condition: true

metaR NDPK4
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dTDP)
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110048#
fast: false
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
reversible: true

metaR DURIPP
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is: SBO:0000176
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
name: deoxyuridine phosphorylase
modifier: MODEL1310110048#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3

http://identifiers.org/biomodels.db/MODEL1310110048#_050d29d3_1bf4_4d11_aefe_5b4ed5b30a01
has only substance units: false
name: PTGS1
is: SBO:0000252
is: P23219
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:5742

metaR GLCSGLT1le
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaM zym int2 r
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:52386
name: zymosterol intermediate 2
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial concentration: 1.0
boundary condition: false

metaM pheme e
is: SBO:0000247
is: HMDB03178
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: Protoheme
has only substance units: false
is: C00032
is: CHEBI:17627

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110048#
reversible: true

metaR r2313
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
product: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaM dhap e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01473
is: CHEBI:57642
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
constant: false
name: glycerone phosphate(2-)
initial amount: NaN
has only substance units: false

metaR LEUKTRE4t
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110048#
name: leukotriene E4 transport
product: MODEL1310110048#

metaM so4 e
is: CHEBI:16189
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01448
name: sulfate
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

http://identifiers.org/biomodels.db/MODEL1310110048#_334a9ba2_461a_4cbc_820a_228c92c6b75a
name: ACSL3
is encoded by: hsa:2181
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: O95573
initial amount: NaN

metaM cdp n
initial amount: NaN
boundary condition: false
type: Species
name: CDP(3-)
initial concentration: 1.0
constant: false
is: CHEBI:58069
has only substance units: false
is: HMDB01546
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaR r1364
kinetic law: MODEL1310110048#
name: Vesicular transport
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM m2mn l
type: Species
is: HMDB06537
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine

metaM octa e
initial amount: NaN
constant: false
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
is: C06423
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:25646
name: octanoate (n-C8:0)
has only substance units: false
is: HMDB00482

http://identifiers.org/biomodels.db/MODEL1310110048#_60dbf0f5_511e_4d64_8f77_c59536c11112
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: P28332
constant: false
boundary condition: true
name: ADH6
is encoded by: hsa:130
is: SBO:0000252

metaR FAOXC163C164Gm
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_da46c05e_da35_4608_a75b_5c7ac34f9c12
initial concentration: NaN
is encoded by: hsa:6541
boundary condition: true
type: Species
constant: false
name: SLC7A1
is: SBO:0000252
initial amount: NaN
is: P30825
has only substance units: false

metaR TPI
name: triose-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000134
fast: false
reactant: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#

metaR NDPK1
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP)

metaM HC01007 c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18102
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
boundary condition: false
has only substance units: false
name: L-Octanoylcarnitine
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_b2815c47_7919_4b4b_ac95_fe89e1303675
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: SLC5A11
is: Q8WWX8
constant: false
is: SBO:0000252
is encoded by: hsa:115584
initial amount: NaN

metaR r1589
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM cholcoa c
is: CHEBI:57373
has only substance units: false
is: SBO:0000247
is: HMDB01374
initial concentration: 1.0
type: Species
boundary condition: false
name: choloyl-CoA(4-)
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN
constant: false

metaR r1626
reversible: true
fast: false
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110048#

metaR r2312
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM ribflv c
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00244
initial amount: NaN
has only substance units: false
name: Riboflavin
type: Species
is: C00255
is: CHEBI:3554
initial concentration: 1.0
notes: FORMULA: C17H20N4O6 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110048#_1a88159c_1c9a_4fa1_9beb_f639fa870877
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: B3GNT3
is: SBO:0000252
type: Species
is: Q9Y2A9
is encoded by: hsa:10331

metaM 34hpp c
type: Species
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
is: HMDB00707
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: SBO:0000247

metaR CYSASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is described by: ECO:0000269
type: Reaction
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
modifier: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false

metaM dadp m
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
is: HMDB01508
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: dADP(3-)
type: Species

metaR GUAt
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
name: Guanine transport
is described by: ECO:0000269
reversible: true

metaR r1365
kinetic law: MODEL1310110048#
is: SBO:0000185
name: Vesicular transport
reversible: false
fast: false
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR NMNATr
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110048#
name: nicotinamide-nucleotide adenylyltransferase
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.7.1
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176

metaR OMHDEACIDTD
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxydecanoic acid by diffusion
type: Reaction

metaR NDPK2
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
name: nucleoside-diphosphate kinase (ATP:UDP)
fast: false
reactant: MODEL1310110048#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR r0960
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
reactant: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is: SBO:0000185
kinetic law: MODEL1310110048#

metaR S6T13g
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110048#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000

metaR HPYRDC
reactant: MODEL1310110048#
type: Reaction
name: hydroxypyruvate decarboxylase
product: MODEL1310110048#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176

metaR r1588
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
reversible: true
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

metaR PIPLCn
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
kinetic law: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
name: phosphatidylinositol phospholipase C, nucleus
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD

metaM txa2 c
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
has only substance units: false
constant: false
type: Species
is: HMDB01452
is: CHEBI:57445
initial concentration: 1.0
is: SBO:0000247
name: thromboxane A2(1-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_e56749d0_bf78_4a2b_88dc_5aa214307e44
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: Q8WZ48
name: CPT1A
is encoded by: hsa:1374

http://identifiers.org/biomodels.db/MODEL1310110048#_20611bec_0961_4d4d_80f1_e1072ce2b711
type: Species
initial concentration: NaN
name: _D87002_1_e
is encoded by: hsa:D87002
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaM pheme c
is: HMDB03178
boundary condition: false
type: Species
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
constant: false
is: C00032
is: CHEBI:17627
initial concentration: 1.0
name: Protoheme
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r2311
reactant: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: SBO:0000185
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110048#
reversible: true

metaR MI13PP
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
name: inositol-1,3-bisphosphate 3-phosphatase
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
is described by: ECO:0000000
type: Reaction

metaR r1627
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM gluside hs c
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
is: SBO:0000247
is: CHEBI:18368
has only substance units: false
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
initial concentration: 1.0
boundary condition: false

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.137
name: phosphatidylinositol 3-kinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
modifier: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
kinetic law: MODEL1310110048#

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM dhap c
initial amount: NaN
type: Species
has only substance units: false
is: C00111
is: HMDB01473
initial concentration: 1.0
constant: false
is: CHEBI:57642
name: Dihydroxyacetone phosphate
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_b78e9d1a_85d5_4be4_a4eb_9705acd7f508
name: HIBADH
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: P31937
type: Species
is encoded by: hsa:11112

http://identifiers.org/biomodels.db/MODEL1310110048#_39c0d9c2_90a6_4cb5_85bf_803b68297f40
name: RPIA
constant: false
boundary condition: true
type: Species
is encoded by: hsa:22934
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P49247
initial concentration: NaN

metaR HISSNAT5tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r0963
kinetic law: MODEL1310110048#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
type: Reaction
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_fe98c436_f4c9_4c2a_961b_893b5f22d046
is encoded by: hsa:55568
name: GALNT10
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q86SR1
boundary condition: true
constant: false
is: SBO:0000252

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR GLYCTDle
is: SBO:0000185
name: difussion of glycerol accross the brush border membrane
kinetic law: MODEL1310110048#
is described by: ECO:0000134
fast: false
product: MODEL1310110048#
reversible: true
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM 10fthf6glu e
is: HMDB00108
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16236
initial concentration: 1.0
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)
has only substance units: false

metaR PRO Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000134
name: D-proline transport, extracellular
product: MODEL1310110048#
reactant: MODEL1310110048#

metaM m8masn g
boundary condition: false
is: C05876
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C70H117N2O55X CHARGE: 0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false

metaR r1628
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM xol7ah2 m
is: CHEBI:28047
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
constant: false
is: HMDB06893
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha-diol
boundary condition: false
has only substance units: false

metaR DCTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110048#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110048#
name: dCTP diffusion in nucleus
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000185

metaM gpail hs c
is: CHEBI:17049
boundary condition: false
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

metaR r2310
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110048#

metaR Htr
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: H transporter, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
is: SBO:0000185

metaR r0899
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110048#
is described by: ECO:0000000
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_5150232c_302b_4d95_b412_fbdc9d05aa4f
is: Q549M5
name: NDUFC2
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4718
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM man6p c
is: HMDB01078
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: D-Mannose 6-phosphate
is: CHEBI:17369
is: SBO:0000247

metaM 34hpp e
type: Species
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: CHEBI:36242
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

metaR SBT Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000134
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: D-sorbitol transport, extracellular
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b42c3a93_d4a9_4817_ae7d_3b9ef44bd098
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:5277
has only substance units: false
name: PIGA
is: P37287
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_88bd36e6_6149_4a8c_b976_ffc666ea7fe8
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P07203
is encoded by: hsa:2876
boundary condition: true
constant: false
name: GPX1
type: Species

metaM prostgf2 e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: CHEBI:57404
boundary condition: false
has only substance units: false
type: Species
is: HMDB01139
name: prostaglandin F2alpha(1-)
constant: false

metaR r0962
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: Facilitated diffusion
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_5fc9dcce_7139_4115_82f4_e4ac09d66a8e
initial amount: NaN
name: _AI684467_1_m
constant: false
type: Species
is encoded by: hsa:AI684467
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR RE2799C
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
name: RE2799
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
fast: false

metaM ksii core4 pre1 g
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 1
initial amount: NaN
is: CHEBI:28067
is: SBO:0000247
notes: FORMULA: C36H60N3O25X CHARGE: 0
boundary condition: false
has only substance units: false
type: Species

metaM grdp x
is: SBO:0000247
is: HMDB01285
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
boundary condition: false
is: CHEBI:58057
initial concentration: 1.0
constant: false
name: geranyl diphosphate(3-)

metaM lanost r
name: lanosterol
constant: false
boundary condition: false
is: HMDB01251
type: Species
is: CHEBI:16521
initial amount: NaN
has only substance units: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial concentration: 1.0
is: SBO:0000247

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
name: 4-nitrophenolate
type: Species
is: HMDB01232
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57917

metaM txa2 e
constant: false
is: HMDB01452
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57445
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: thromboxane A2(1-)

http://identifiers.org/biomodels.db/MODEL1310110048#_25d13a5c_daeb_4749_bd77_939ea328daaa
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: C9JFZ1
boundary condition: true
type: Species
constant: false
is encoded by: hsa:8867
name: SYNJ1
has only substance units: false

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaR r0013
modifier: MODEL1310110048#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:

metaM dad 2 c
constant: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
type: Species
is: CHEBI:17256
initial concentration: 1.0
boundary condition: false
name: 2-deoxyadenosine
has only substance units: false
initial amount: NaN
is: HMDB00101
is: SBO:0000247

metaR OXAHCOtex
product: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110048#
is: SBO:0000185
name: oxalate transport via bicarbonate countertransport
fast: false
is described by: ECO:0000304
reactant: MODEL1310110048#

metaM o2s c
is: HMDB02168
name: superoxide
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:18421
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species
constant: false

metaR UGLCNACtg
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
name: UDP-GlcNAc Golgi transport via CMP antiport

http://identifiers.org/biomodels.db/MODEL1310110048#_adf51661_b9f1_4f39_8505_6f37157ed581
constant: false
has only substance units: false
is: Q6I9V5
type: Species
boundary condition: true
is encoded by: hsa:293
name: SLC25A6
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR SERtN1
name: Serine transport (Na, H coupled)
type: Reaction
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#
is described by: ECO:0000269
modifier: MODEL1310110048#
is: SBO:0000185

metaR r0812
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
modifier: MODEL1310110048#
fast: false

metaR r1636
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110048#

metaM tchola c
name: taurocholic acid
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: HMDB00036
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:36257
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_37396384_7975_4b2e_a2e7_d88c50fc521a
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:1545
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q16678
constant: false
name: CYP1B1

metaM rbt e
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:15963
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00508
type: Species
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380

metaM 5adtststerone e
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
is: CHEBI:16330
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_2e9d292e_1530_49a4_a464_fda770d54d6d
type: Species
is encoded by: hsa:4719
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: NDUFS1
has only substance units: false
is: P28331

metaM dlnlcgcoa c
is: CHEBI:27979
constant: false
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
is: SBO:0000247

metaM 7dhchsterol c
constant: false
is: CHEBI:17759
initial concentration: 1.0
initial amount: NaN
type: Species
name: cholesta-5,7-dien-3beta-ol
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: SBO:0000247
has only substance units: false
is: HMDB00032

http://identifiers.org/biomodels.db/MODEL1310110048#_508d652c_1bdc_4c23_90c7_5530484c0a4f
type: Species
initial concentration: NaN
is: O43678
initial amount: NaN
boundary condition: true
name: NDUFA2
is encoded by: hsa:4695
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_c2a48c5b_bc07_49a3_8dff_37edc35f3c2d
has only substance units: false
name: ALDH1A2
is: O94788
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:8854
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM 5pmev c
name: (R)-5-phosphonatomevalonate(3-)
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
is: HMDB01343
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_40cbcd28_0898_47db_8501_ab435b84707f
is encoded by: hsa:2629
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: B7Z6S1
constant: false
initial amount: NaN
name: GBA

metaR r2330
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_79059300_be9f_4752_9759_f9ff3a8b5b0c
is: Q14542
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SLC29A2
is encoded by: hsa:3177
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_d701ace4_e10a_4dca_82d8_9a3d52a05d3e
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1891
name: ECH1
is: SBO:0000252
has only substance units: false
constant: false
is: Q13011
type: Species

metaM HC02187 e
type: Species
has only substance units: false
name: reverse-triiodthyronine
is: CHEBI:28774
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
initial amount: NaN

metaR ADRNt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_66ee97f2_8e9b_4f19_91e4_e1bf5d900288
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:81537
name: SGPP1
constant: false
boundary condition: true
type: Species
is: Q9BX95
is: SBO:0000252
has only substance units: false

metaM k c
has only substance units: false
name: potassium
type: Species
is: C00238
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:29103
is: SBO:0000247
initial amount: NaN
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

metaM dnad c
type: Species
is: C00857
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18304
constant: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
boundary condition: false
is: HMDB01179
has only substance units: false
name: Deamino-NAD+
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_a8c5233d_aa93_482d_bf07_d48f692c431b
is encoded by: hsa:4832
is: Q13232
name: NME3
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r1635
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#

metaR r2331
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

metaM imp c
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: C00130
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
name: IMP
constant: false
boundary condition: false

metaM ac m
boundary condition: false
initial amount: NaN
name: acetate
constant: false
initial concentration: 1.0
is: HMDB00042
is: CHEBI:30089
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaM pac c
constant: false
name: phenylacetate
is: CHEBI:18401
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: HMDB00209
boundary condition: false
type: Species

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_d7cbb514_7802_43a5_b373_66a52f3c0999
name: GBA
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2629
type: Species
constant: false

metaM dad 2 e
is: CHEBI:17256
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
boundary condition: false
name: 2-deoxyadenosine
initial amount: NaN
is: HMDB00101
has only substance units: false
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_86b09c0f_071a_4894_b78a_b88adb9e1282
boundary condition: true
initial concentration: NaN
name: RPE
has only substance units: false
is encoded by: hsa:6120
type: Species
is: Q96AT9
initial amount: NaN
constant: false
is: SBO:0000252

metaM malttr e
type: Species
initial concentration: 1.0
is: C01835
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01262
name: maltotriose
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: CHEBI:27931
constant: false

metaM naglc2p U c
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
is: CHEBI:18278
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_e10c57d4_b078_4af9_ac95_24904a067e69
type: Species
is: A8K761
has only substance units: false
is encoded by: hsa:4716
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: NDUFB10
constant: false
boundary condition: true

metaR FACOAL204
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is: SBO:0000176
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110048#_eca74263_2fca_419e_9e20_b7218810d225
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: AK4
is encoded by: hsa:205
constant: false
is: SBO:0000252
boundary condition: true

metaR r0480
kinetic law: MODEL1310110048#
fast: false
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
product: MODEL1310110048#

metaR FAOXTC122m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaR S6T11g
type: Reaction
product: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is: SBO:0000176

metaR ADSL1
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is: SBO:0000176
name: adenylosuccinate lyase
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_d1543a3b_eacb_4fa5_be5d_971c5d00171f
initial amount: NaN
has only substance units: false
is encoded by: hsa:10637
is: SBO:0000252
name: LEFTY1
boundary condition: true
is: O75610
constant: false
initial concentration: NaN
type: Species

metaR r1634
type: Reaction
is: SBO:0000185
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110048#
is described by: ECO:0000000

metaR r0885
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is: SBO:0000185
is described by: ECO:0000000
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR GULNDer
kinetic law: MODEL1310110048#
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110048#
name: gulonate dehydrogenase, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
type: Reaction
reactant: MODEL1310110048#

metaM ppi r
has only substance units: false
is: C00013
boundary condition: false
initial concentration: 1.0
type: Species
name: Diphosphate
is: CHEBI:33019
is: SBO:0000247
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
constant: false

metaM glu L m
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
is: SBO:0000247
has only substance units: false
name: L-glutamate(1-)
is: CHEBI:29985
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_4b403395_cb96_4d82_88f4_2763ce3d58a0
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: PYCRL
is: Q53H96
is encoded by: hsa:65263
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_fa8d05c7_789f_4a64_8e04_cebcbe3fe019
name: _F23536_1_m
initial amount: NaN
type: Species
is encoded by: hsa:F23536
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR r2332
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_ac645bea_7d22_4085_9b89_b0466748fb4b
initial amount: NaN
is: Q53G02
is encoded by: hsa:1603
name: DAD1
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR MACACI
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: false
name: maleylacetoacetate isomerase

metaR THRGLNexR
product: MODEL1310110048#
is described by: ECO:0000304
kinetic law: MODEL1310110048#
fast: false
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
is: SBO:0000185
type: Reaction

metaM 5adtststerone c
constant: false
is: HMDB02961
initial concentration: 1.0
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917

metaM prostgh2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: prostaglandin H2(1-)
is: SBO:0000247
is: CHEBI:57405
is: HMDB01381
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_e1c486c7_657b_4658_a868_c218729f07ec
boundary condition: true
type: Species
initial concentration: NaN
is: Q8TB61
initial amount: NaN
constant: false
is encoded by: hsa:347734
has only substance units: false
is: SBO:0000252
name: SLC35B2

http://identifiers.org/biomodels.db/MODEL1310110048#_52260b15_d6a0_4a20_ad03_20b58d0b58d7
name: ACAA1
is: SBO:0000252
type: Species
is encoded by: hsa:30
constant: false
initial amount: NaN
is: Q96CA6
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4cdcc3cf_9b56_43e1_92a1_c727e4ca84cf
initial amount: NaN
constant: false
is: SBO:0000252
name: NDUFS2
has only substance units: false
boundary condition: true
is encoded by: hsa:4720
initial concentration: NaN
type: Species
is: B7Z792

metaR ADSL2
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110048#
is described by: ECO:0000269
is: SBO:0000176
name: adenylosuccinate lyase
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
reversible: false
kinetic law: MODEL1310110048#

metaM betald c
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:15710
is: HMDB01252
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
type: Species
name: betaine aldehyde
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_93b3f159_4946_4495_9e6c_ab60f6423485
initial concentration: NaN
name: GGT1
is encoded by: hsa:2678
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: P19440
has only substance units: false

metaM xol7ah2 c
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
is: CHEBI:28047
is: HMDB06893
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

metaM HC02187 c
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: reverse-triiodthyronine
is: CHEBI:28774
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
constant: false

metaR r1633
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
fast: false
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_50a94564_42bb_47b9_9cc0_c3d7be90949f
has part: B2RAU6
is: SBO:0000297
constant: false
is encoded by: hsa:51227
has only substance units: false
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5277
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9091
type: Species
has part: P57054
is encoded by: hsa:5279

metaR PNTOte
is described by: ECO:0000134
reversible: true
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110048#
name: Transport of (R)-Pantothenate
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000185
fast: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM k e
is: C00238
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
has only substance units: false
name: potassium
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00586
is: CHEBI:29103

metaR ACNAMlt
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is: SBO:0000185
type: Reaction
name: N-acetylneuraminate transport into lysososme
reversible: true
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110048#_afcf8780_fbac_4fd8_b765_aa4ebd6f7550
has only substance units: false
initial amount: NaN
is: P32322
name: PYCR1
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5831
constant: false

metaM dgchol c
boundary condition: false
initial amount: NaN
name: glycochenodeoxycholate
initial concentration: 1.0
constant: false
is: HMDB00637
is: SBO:0000247
is: CHEBI:36252
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species

metaM em2emgacpail hs r
has only substance units: false
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
initial concentration: 1.0
constant: false
is: CHEBI:16038
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_2d10bfc0_fabf_47a5_bf53_ac08468d0258
is: Q05C14
name: FOLR3
type: Species
is encoded by: hsa:2352
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r2333
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000

metaR SERALANaEx
reactant: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
kinetic law: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
type: Reaction
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR BDMT U
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.142
product: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
fast: false
type: Reaction
is: SBO:0000176

metaR GGH 10FTHF6GLUe
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110048#
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular

http://identifiers.org/biomodels.db/MODEL1310110048#_ef4c4c63_9678_4a3e_abaf_971984d65ef0
has only substance units: false
has part: O15254
name: EHHADH:ACAA1:HSD17B4:ACOX3
has part: Q9NY65
initial amount: NaN
is: SBO:0000297
type: Species
boundary condition: true
is encoded by: hsa:1962
is encoded by: hsa:8310
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_e75e24c2_8e26_4558_8289_54dda56f66cf
type: Species
initial concentration: NaN
has only substance units: false
name: PC
boundary condition: true
is encoded by: hsa:5091
initial amount: NaN
constant: false
is: SBO:0000252

metaM cdp c
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
is: CHEBI:58069
type: Species
name: CDP
initial amount: NaN
is: C00112
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_bfc95350_9521_41da_aee5_59e67a423616
constant: false
is encoded by: hsa:115111
initial concentration: NaN
name: SLC26A7
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_8012c20e_1bd3_4ef2_84fd_bd149aa4e361
initial concentration: NaN
constant: false
is encoded by: hsa:1798
name: DPAGT1
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9H3H5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_f4e65942_68ab_4351_b2af_b00cef4912dd
boundary condition: true
is encoded by: hsa:80271
initial amount: NaN
name: ITPKC
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: Q96DU7
is: SBO:0000252

metaR r1632
modifier: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110048#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction

metaR FACOAL206
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110048#
is described by: ECO:0000269
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
name: fatty-acid--CoA ligase
modifier: MODEL1310110048#

metaM CE5132 c
is: SBO:0000247
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial amount: NaN
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110048#_820cddf5_7907_4238_b52b_e366e4bf96a1
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6391
has only substance units: false
is: Q99643
name: SDHC
is: SBO:0000252
initial amount: NaN

metaR TRPHYDRO2
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.14.16.4
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reversible: false

metaM f6p c
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124
type: Species
constant: false
boundary condition: false
is: CHEBI:57579
initial amount: NaN
is: C00085
name: D-Fructose 6-phosphate
is: SBO:0000247

metaR NDPK7n
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
reactant: MODEL1310110048#
is: SBO:0000176
reversible: true
modifier: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR BPNT
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
fast: false
modifier: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269
name: 3',5'-bisphosphate nucleotidase

metaR r0669
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110048#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reactant: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#

metaM ru5p D c
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58121
name: D-ribulose 5-phosphate(2-)
boundary condition: false
type: Species
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR r1583
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
fast: false
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM glu L l
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
initial amount: NaN
is: HMDB00148
is: SBO:0000247
is: CHEBI:29985
has only substance units: false
type: Species
initial concentration: 1.0
name: L-glutamate(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6ff3978b_523b_49f5_a1fc_7592d8e6fca1
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
name: ST3GAL4
is: Q6IBE6
is encoded by: hsa:6484
initial concentration: NaN
is: SBO:0000252

metaR r1631
reactant: MODEL1310110048#
type: Reaction
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_1aa4d8ab_0835_4560_8ae0_59967c0541cb
boundary condition: true
is: SBO:0000252
name: AK2
initial concentration: NaN
is encoded by: hsa:204
constant: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_a7b302f2_9929_45b2_89b3_cae142390dec
is: SBO:0000252
is encoded by: hsa:56954
initial concentration: NaN
is: Q9NQR4
type: Species
boundary condition: true
has only substance units: false
name: NIT2
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6982aea6_6aaf_49d2_a904_6532fea6e996
type: Species
is: SBO:0000252
name: MAN1C1
is encoded by: hsa:57134
has only substance units: false
initial concentration: NaN
constant: false
is: Q9NR34
boundary condition: true
initial amount: NaN

metaM pan4p m
is: HMDB01416
is: CHEBI:47942
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
type: Species
name: pantetheine 4'-phosphate(2-)
is: SBO:0000247
has only substance units: false

metaR ALOX5
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
modifier: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.13.11.34
reactant: MODEL1310110048#
fast: false
name: Arachidonate 5-lipoxygenase
type: Reaction

metaR UMPK5n
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP),nuclear
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_1d44443b_9ae7_42c4_ade9_afb1bbeaa78b
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11001
name: SLC27A2
type: Species
is: O14975
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM tcynt c
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
is: SBO:0000247
initial amount: NaN
name: thiocyanate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:18022
constant: false
is: HMDB01453

metaM dgchol e
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
constant: false
is: HMDB00637
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:36252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_70713199_fff8_4f6d_a1ad_ae1367ffbae1
constant: false
name: GSR
boundary condition: true
is: P00390
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2936
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_3d2ff112_a391_42fb_b6ca_47b2cb0463df
type: Species
name: _AI378339_1_m
is: SBO:0000252
is encoded by: hsa:AI378339
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaR MI1PP
modifier: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
name: myo-inositol 1-phosphatase
is described by: ECO:0000269
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaR r1630
reactant: MODEL1310110048#
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#

metaM cdp e
is: CHEBI:58069
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: CDP(3-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546

metaR r2511
name: Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false

metaM o2s e
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB02168
is: CHEBI:18421
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide

metaR r1580
fast: false
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM nadh c
constant: false
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
has only substance units: false
is: CHEBI:57945
initial concentration: 1.0
initial amount: NaN
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_36c4e56e_4f82_4915_8c0a_80561478d947
is: P43353
constant: false
is: SBO:0000252
is encoded by: hsa:221
type: Species
boundary condition: true
name: ALDH3B1
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR RE1845C
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
name: RE1845
is: SBO:0000176

metaM dolglcp U c
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: CHEBI:15812
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9d2431f7_47e3_4843_9634_d2fc8c80b91b
is: SBO:0000252
name: INPP5J
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:27124

metaR r0818
product: MODEL1310110048#
is: SBO:0000185
reversible: false
name: Transport reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
type: Reaction

metaM fad e
boundary condition: false
is: C00016
is: HMDB01248
has only substance units: false
type: Species
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
is: CHEBI:16238
constant: false
initial concentration: 1.0

metaM gly m
type: Species
is: HMDB00123
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00037
name: Glycine
initial amount: NaN
is: CHEBI:15428
has only substance units: false
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037

http://identifiers.org/biomodels.db/MODEL1310110048#_9ae4100c_19ab_4633_9d4d_6ded661c38de
constant: false
initial amount: NaN
is encoded by: hsa:51227
type: Species
has only substance units: false
initial concentration: NaN
is: P57054
name: PIGP
is: SBO:0000252
boundary condition: true

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR Htx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: true
product: MODEL1310110048#
name: H transporter, peroxisome
is: SBO:0000185
fast: false

metaM methf c
type: Species
name: 5,10-Methenyltetrahydrofolate
boundary condition: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
constant: false
has only substance units: false
is: CHEBI:57455
is: C00445
is: SBO:0000247
is: HMDB01354
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_d199a124_bf88_4adf_b5d1_9e1823afd293
is: P24752
boundary condition: true
is encoded by: hsa:38
has only substance units: false
is: SBO:0000252
name: ACAT1
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaR PI345P5P
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
kinetic law: MODEL1310110048#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
is: SBO:0000176

metaR CYTK1n
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
name: cytidylate kinase (CMP),nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110048#
is: SBO:0000176

metaR RE2954C
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
fast: false
name: RE2954
product: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110048#

metaM fad c
initial concentration: 1.0
is: C00016
is: CHEBI:16238
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
is: HMDB01248
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247

metaR r1581
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ead812c4_578b_4c0b_93a9_717a7ff9dc79
initial amount: NaN
type: Species
name: ADH1B
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: P00325
is encoded by: hsa:125
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_0f693f09_1978_4b56_83e8_423d331626b9
is encoded by: hsa:6576
type: Species
is: SBO:0000252
name: SLC25A1
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: D9HTE9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_7b529b8d_d25d_4f5a_8842_24f653a63309
is encoded by: hsa:27068
is: SBO:0000252
initial amount: NaN
name: PPA2
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaM gm3 hs g
initial amount: NaN
is: CHEBI:60065
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
constant: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
type: Species
is: SBO:0000247
boundary condition: false

metaR LPCHOLt
is: SBO:0000185
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: lysophosphatidylcholine transport
product: MODEL1310110048#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
reactant: MODEL1310110048#
type: Reaction

metaM thexddcoa m
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
boundary condition: false
name: trans7,10-hexadecadienoylcoa
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB02288

metaM tcynt e
initial amount: NaN
is: CHEBI:18022
constant: false
is: HMDB01453
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
name: thiocyanate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_f250718e_b74f_4d1c_b1b5_a23e14d85e5d
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5337
boundary condition: true
has only substance units: false
is: Q59EA4
initial concentration: NaN
type: Species
name: PLD1

metaM c226crn m
constant: false
boundary condition: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/127055
is: HMDB06510
has only substance units: false
name: cervonyl carnitine
initial amount: NaN
is: SBO:0000247

metaM pmtcrn c
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
is: HMDB00222
has only substance units: false
name: L-palmitoylcarnitine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17490
boundary condition: false
constant: false

metaR r0817
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
fast: false
is described by: ECO:0000000
modifier: MODEL1310110048#
type: Reaction

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_75a65f74_66ec_4391_8b0d_b6eb459d3eca
boundary condition: true
initial amount: NaN
type: Species
name: GPX1
constant: false
is encoded by: hsa:2876
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM ppi x
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
boundary condition: false
is: CHEBI:33019
is: C00013
constant: false
has only substance units: false
name: Diphosphate
is: SBO:0000247
is: HMDB00250
type: Species
initial amount: NaN

metaR r2115
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185

metaM nadh m
constant: false
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
is: C00004
is: CHEBI:57945
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR PRASCS
is version of: http://identifiers.org/ec-code/6.3.2.6
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
modifier: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
type: Reaction
is: SBO:0000176

metaR C10DCc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaM m5mpdol U r
initial concentration: 1.0
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:37634
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM 3dhguln c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: CHEBI:57655
initial amount: NaN
has only substance units: false
name: 3-dehydro-L-gulonate
type: Species
is: SBO:0000247
is: HMDB06334
constant: false
boundary condition: false
initial concentration: 1.0

metaR r0512
is: SBO:0000176
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
modifier: MODEL1310110048#

metaR UREAt
reversible: true
modifier: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269
name: Urea transport via facilitate diffusion

metaR MCPST
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: false
is: SBO:0000176
name: 3-mercaptopyruvate sulfurtransferase
product: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.8.1.2
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells

metaM r5p c
type: Species
is: HMDB00618
boundary condition: false
is: CHEBI:18189
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
initial amount: NaN
initial concentration: 1.0
is: C00117
has only substance units: false
name: alpha-D-Ribose 5-phosphate

metaR GALtly
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
name: galactose efflux from lysosome
product: MODEL1310110048#
fast: false
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000

metaM fad r
boundary condition: false
is: CHEBI:16238
has only substance units: false
type: Species
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: HMDB01248
initial amount: NaN
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

http://identifiers.org/biomodels.db/MODEL1310110048#_520f7c99_7d79_4e69_9843_65617484a067
is: Q96RN1
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:116369
name: SLC26A8
is: SBO:0000252

metaR CHOLt4
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
reversible: true
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
name: choline, sodium cotransport
is described by: ECO:0000269

metaM lac D e
is: CHEBI:16004
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01311
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
name: (R)-lactate
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6c785e47_98e1_45e9_b923_f23a406577f0
has only substance units: false
is: Q9BWD1
type: Species
initial amount: NaN
is: SBO:0000252
name: ACAT2
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:39

http://identifiers.org/biomodels.db/MODEL1310110048#_82b5a7c2_c6c4_47bc_b1ef_f9c69e1c8f4f
name: NDUFA9
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4704
initial amount: NaN
is: SBO:0000252
is: Q16795
has only substance units: false
constant: false
type: Species

metaM txa2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
boundary condition: false
is: HMDB01452
initial concentration: 1.0
is: CHEBI:57445
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: thromboxane A2(1-)
type: Species
constant: false

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR RE1517M
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
type: Reaction
name: RE1517
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110048#
is described by: ECO:0000000

metaM ac e
type: Species
is: CHEBI:30089
name: acetate
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00042
has only substance units: false

metaM pchol hs c
name: Phosphatidylcholine
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species

metaR DDPGAm
reactant: MODEL1310110048#
fast: false
type: Reaction
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
kinetic law: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3907f41b_bec7_488b_a749_59db931c6218
has only substance units: false
name: SCD
type: Species
is: O00767
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6319
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_24c07fee_b462_4114_ad45_c300e634b545
name: ALDOA
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:226
initial concentration: NaN
is: P04075

http://identifiers.org/biomodels.db/MODEL1310110048#_1440cdf3_984b_48c1_911b_e7a2081864bc
is: SBO:0000252
constant: false
is: Q9P0Z9
initial concentration: NaN
type: Species
has only substance units: false
name: PIPOX
boundary condition: true
initial amount: NaN
is encoded by: hsa:51268

metaR S6T1g
is described by: ECO:0000000
product: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
type: Reaction

metaR GluForTx
is: SBO:0000176
modifier: MODEL1310110048#
name: Glutamate formimidoyltransferase
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.1.2.5
fast: false
product: MODEL1310110048#
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110048#

metaM methf m
is: SBO:0000247
has only substance units: false
is: HMDB01354
initial amount: NaN
is: CHEBI:57455
type: Species
name: (6R)-5,10-methenyltetrahydrofolate
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
boundary condition: false
constant: false

metaR r1981
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110048#
reversible: false
fast: false
reactant: MODEL1310110048#
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_72216aba_a664_4374_aed3_011edc8e25c5
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:5287
is: SBO:0000252
is: O00750
name: PIK3C2B
initial concentration: NaN
boundary condition: true

metaM datp c
type: Species
initial concentration: 1.0
name: dATP
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
is: HMDB01532
is: CHEBI:61404
is: C00131
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_caea9a85_df2e_44b8_a790_e53440ea2e04
is: O15244
name: SLC22A2
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6582

metaR RE2626M
reactant: MODEL1310110048#
name: RE2626
kinetic law: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR r0594
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reversible: true
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
kinetic law: MODEL1310110048#

metaR DNDPt34m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269
is: SBO:0000185
name: dGDP transport via dTDP antiport
modifier: MODEL1310110048#

metaM tyr L e
name: L-tyrosine
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17895
initial amount: NaN
is: HMDB00158

metaR r2113
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110048#

metaR r0514
fast: false
type: Reaction
modifier: MODEL1310110048#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110048#

metaR DCK1n
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
name: Deoxycytidine kinase, nuclear (ATP)
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.74

metaR CHOLATEt
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: cholate transport via bicarbonate countertransport
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269

metaR G14T13g
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110048#

metaM CE4872 m
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial amount: NaN
is: HMDB00127
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_5a52863d_f348_486b_8437_ef01df30c5b3
is: O75452
name: RDH16
is encoded by: hsa:8608
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_aff4dfab_9106_4e71_9593_03c45d0af5d1
is encoded by: hsa:3417
boundary condition: true
type: Species
constant: false
name: IDH1
is: SBO:0000252
has only substance units: false
is: O75874
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_4821c0d7_26c7_44f5_b02a_dd143e21aece
type: Species
is encoded by: hsa:4536
name: ND2
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q7GXY9
has only substance units: false

metaR G14T20g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110048#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction

metaM thyox L c
has only substance units: false
is: SBO:0000247
name: L-thyroxine
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:18332
is: HMDB00248
initial amount: NaN

metaR MECOALm
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110048#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110048#
reversible: true
is: SBO:0000176
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110048#

metaR r1148
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Active transport
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000000

metaR PPItm
reactant: MODEL1310110048#
reversible: true
name: diphopshate transporter, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is described by: ECO:0000134
fast: false

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR DUTPDPn
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.6.1.23
product: MODEL1310110048#
name: dUTP diphosphatase, nuclear
is described by: ECO:0000269
reactant: MODEL1310110048#

metaR ORPT
reactant: MODEL1310110048#
type: Reaction
name: orotate phosphoribosyltransferase
kinetic law: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is: SBO:0000176
product: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.10
modifier: MODEL1310110048#
reversible: true

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR FAOXC16BRx
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaM dcsptn1crn m
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
is: HMDB06321
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false

metaM HC01401 m
boundary condition: false
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
is: CHEBI:27668

metaR r2112
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_e1f0cb94_85bf_4c40_9221_14c700eb485c
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: P39877
boundary condition: true
is encoded by: hsa:5322
name: PLA2G5

http://identifiers.org/biomodels.db/MODEL1310110048#_fa2f86fd_eb43_4bc1_8f9c_50524d4d32ae
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: TUSC3
type: Species
initial concentration: NaN
is encoded by: hsa:7991
is: Q13454

http://identifiers.org/biomodels.db/MODEL1310110048#_81f8bef9_d482_45c4_ab37_4c2041265e10
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O43916
initial amount: NaN
type: Species
is encoded by: hsa:8534
constant: false
name: CHST1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_84136e59_9277_4777_acfc_fab885cae763
initial amount: NaN
is encoded by: hsa:51079
type: Species
is: Q9P0J0
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: NDUFA13
constant: false
has only substance units: false

metaR NTD6
reactant: MODEL1310110048#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
name: 5'-nucleotidase (dAMP)
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_234e39da_4f3b_45e4_83f6_697899b88f23
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AI694761
type: Species
name: _AI694761_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM pchol hs e
is: SBO:0000247
initial amount: NaN
name: Phosphatidylcholine
initial concentration: 1.0
is: CHEBI:16110
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
constant: false

metaM gly x
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: CHEBI:15428
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
has only substance units: false
name: glycine
is: HMDB00123
initial amount: NaN

metaM ac c
boundary condition: false
has only substance units: false
constant: false
name: acetate
is: SBO:0000247
is: CHEBI:30089
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

http://identifiers.org/biomodels.db/MODEL1310110048#_8407534b_4457_4ba9_a424_46e0b52436ab
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ACAA2
is: SBO:0000252
constant: false
is: P42765
is encoded by: hsa:10449
type: Species

metaM lac D c
is: CHEBI:16004
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
name: (R)-lactate
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01311
constant: false

metaM 3hmp m
type: Species
is: HMDB00023
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:11805
name: 3-hydroxy-2-methylpropanoate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_1682503c_98c5_4432_a79b_7f3144b95cd9
has only substance units: false
initial concentration: NaN
is: Q9UBQ7
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9380
name: GRHPR

metaR RE2999M
reactant: MODEL1310110048#
product: MODEL1310110048#
name: RE2999
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110048#
is: SBO:0000176

metaM spmd c
constant: false
is: CHEBI:57834
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
is: HMDB01257
type: Species
boundary condition: false
is: C00315
initial amount: NaN
name: Spermidine

http://identifiers.org/biomodels.db/MODEL1310110048#_c29e8736_e294_4a3b_884b_f93a66ec85e8
is: P14550
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: AKR1A1
initial concentration: NaN
is encoded by: hsa:10327
has only substance units: false
initial amount: NaN

metaM tyr L c
initial amount: NaN
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17895
name: L-tyrosine

http://identifiers.org/biomodels.db/MODEL1310110048#_933dc981_7df4_4450_905a_fefed808f872
initial amount: NaN
constant: false
name: PPCDC
is: SBO:0000252
is encoded by: hsa:60490
is: Q96CD2
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_33c20722_c0aa_43db_ab49_17258f77096e
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:30833
is: SBO:0000252
is: Q8TCD5
boundary condition: true
name: NT5C

metaR DSREDUCr
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
fast: false
modifier: MODEL1310110048#
name: Desmosterol reductase
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72

http://identifiers.org/biomodels.db/MODEL1310110048#_8ecb3537_9698_4144_bcb5_7d963478d11a
is: SBO:0000252
has only substance units: false
constant: false
name: _R51273_1_c
is encoded by: hsa:R51273
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaR LEUPHELAT2tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM thp2c x
initial amount: NaN
name: 1-piperideine-6-carboxylate
constant: false
is: SBO:0000247
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
type: Species
has only substance units: false
boundary condition: false
is: HMDB12130
initial concentration: 1.0
is: CHEBI:16987

metaR UDPGLCAter
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
is: SBO:0000185
reversible: true
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269

metaR r1527
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.1
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_3fc56529_00b1_4b66_b484_b362f109f09b
name: ACP6
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:51205
is: SBO:0000252
initial concentration: NaN
is: Q9NPH0
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b15a7779_7891_49bb_a2b9_534a88b87e65
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: BAAT
has only substance units: false
is encoded by: hsa:570
is: Q14032

metaR r2111
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM ametam c
is: CHEBI:57443
is: HMDB00988
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
has only substance units: false
boundary condition: false
is: C01137
type: Species
constant: false
name: S-Adenosylmethioninamine
initial amount: NaN

metaM forglu c
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: HMDB00854
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: N-Formimidoyl-L-glutamate
is: C00439
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:18327

http://identifiers.org/biomodels.db/MODEL1310110048#_531f37c1_5f9e_4b64_acfc_34829ab934e1
constant: false
name: ACSL5
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9ULC5
is encoded by: hsa:51703

http://identifiers.org/biomodels.db/MODEL1310110048#_033b2c44_30b2_4e98_80cd_61e53f7a17e8
constant: false
boundary condition: true
is encoded by: hsa:1836
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P50443
name: SLC26A2
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_995bd889_c297_4d19_9a4c_9620a3c27cce
name: B3GNT8
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:374907
is: Q7Z7M8

metaR MEVK1c
name: mevalonate kinase (atp) cytosol
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
type: Reaction
product: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.36

metaR NODe
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
is described by: ECO:0000134
type: Reaction
name: NODe
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110048#
is: SBO:0000185

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a4213a64_38d0_4394_a057_145d782674be
name: ALDH3B2
boundary condition: true
is: P48448
type: Species
is encoded by: hsa:222
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_a658b79d_915e_4166_a60e_abc1381bd309
name: NDUFS1
is encoded by: hsa:4719
is: P28331
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaR 3SALAASPm
fast: false
type: Reaction
name: cysteinesulfinate-aspartate mitochondrial shuttle
is: SBO:0000185
modifier: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000304
product: MODEL1310110048#

metaR CYTK8
modifier: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (CMP,dATP)
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_413b5bb2_592c_4751_baea_83d2fbc23bd3
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: NDUFB4
is encoded by: hsa:4710
is: O95168
constant: false
is: SBO:0000252
initial amount: NaN

metaM tdcoa c
has only substance units: false
is: C02593
initial amount: NaN
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01521
name: Tetradecanoyl-CoA (n-C14:0CoA)

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR CTPtn
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
name: CTP diffusion in nucleus
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction

metaM aps c
has only substance units: false
constant: false
is: HMDB01003
name: 5'-adenylyl sulfate(2-)
is: CHEBI:58243
boundary condition: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

metaM mgacpail hs r
is: CHEBI:7896
initial concentration: 1.0
constant: false
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: HMDB00220
is: C00249

metaR NH4t3r
type: Reaction
is: SBO:0000185
modifier: MODEL1310110048#
name: ammonia transport via proton antiport
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
reversible: true
fast: false
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
kinetic law: MODEL1310110048#

metaM i e
boundary condition: false
is: HMDB12238
is: CHEBI:16382
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: SBO:0000247
name: iodide
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_bbf7bfeb_0298_4508_ac36_534bc47c9ed0
type: Species
is: SBO:0000252
has only substance units: false
is: Q86WU2
name: LDHD
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:197257

metaR ALCD2yf
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110048#
is described by: ECO:0000134
reactant: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: alcohol dehydrogenase (ethanol, NADP), forward reaction

metaR r2110
fast: false
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110048#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110048#

metaR MI134P4P
reactant: MODEL1310110048#
name: inositol-1,3,4-trisphosphate 4-phosphatase
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false

metaM tddedicoa m
name: trans3,6dodecadienoylcoa
is: SBO:0000247
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280771
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaM pail hs n
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)

metaR H2MTer L
product: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
fast: false
type: Reaction
name: H2 mannosyltransferase, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#

metaR FAOXC81C61m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaM Ssq23epx r
constant: false
is: SBO:0000247
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
initial concentration: 1.0
type: Species
is: CHEBI:15441
initial amount: NaN
boundary condition: false
has only substance units: false
name: (S)-2,3-epoxysqualene
is: HMDB01188

metaR r0517
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37

metaM ala D c
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
type: Species
name: D-alanine
is: CHEBI:15570

http://identifiers.org/biomodels.db/MODEL1310110048#_3b7bf503_1860_4357_9cbc_3c5b71050045
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O95436
initial amount: NaN
name: SLC34A2
is encoded by: hsa:10568
type: Species
is: SBO:0000252
constant: false

metaR AKGtp
is: SBO:0000185
name: AKG transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#

metaR It
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
name: Iodide uniport
is described by: ECO:0000269
product: MODEL1310110048#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185

metaM pail3p hs c
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:58088
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
constant: false
boundary condition: false

metaM hestratriol r
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB05896
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
name: 4,17 dihydroxy estradiol
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_e7697ac0_dc88_4bea_8b2a_ab2298707dcb
has only substance units: false
is encoded by: hsa:AU149534
initial amount: NaN
name: _AU149534_1_e
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaR CYTK9
fast: false
reactant: MODEL1310110048#
name: cytidylate kinase (CMP,dCTP)
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_8b755a44_00e6_4dc1_9171_fd8935711a50
type: Species
name: ADSSL1
is encoded by: hsa:122622
boundary condition: true
is: Q8N142
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR CYSGLYexR
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
name: L-cysteine/glycine reversible exchanger
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_72f362c3_f80a_4552_8181_11934931a224
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P56181
name: NDUFV3
type: Species
is encoded by: hsa:4731
initial concentration: NaN
constant: false
initial amount: NaN

metaR PPItr
name: Diphosphate transporter, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false

metaR r1257
reactant: MODEL1310110048#
name: EC:6.2.1.3
kinetic law: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
reversible: false
fast: false
type: Reaction

metaR CYTK5
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
name: cytidylate kinase (dCMP)
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110048#

metaM o2s m
has only substance units: false
is: CHEBI:18421
initial amount: NaN
boundary condition: false
name: Superoxide anion
is: HMDB02168
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: C00704
initial concentration: 1.0
type: Species
constant: false

metaR r2519
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
name: Utilized transport
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110048#

metaM pyr m
name: pyruvate
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:15361
constant: false
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
is: HMDB00243
initial concentration: 1.0
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

metaM tchola e
has only substance units: false
name: taurocholic acid
type: Species
is: HMDB00036
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN

metaR SERDGLNexR
kinetic law: MODEL1310110048#
is described by: ECO:0000304
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110048#
name: D-Serine/Glutamine reversible exchange
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_58a822ab_3cda_4e58_8417_9a8532f42dae
initial concentration: NaN
is: Q9Y259
is: SBO:0000252
is encoded by: hsa:1120
name: CHKB
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM rbt c
is: HMDB00508
initial concentration: 1.0
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15963
boundary condition: false

metaM fad m
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
is: CHEBI:16238
constant: false
initial concentration: 1.0
is: C00016
is: HMDB01248
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR FAOXC122m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM frdp r
is: C00448
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:175763
is: HMDB00961
has only substance units: false
name: Farnesyl diphosphate
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0

metaM HC00319 m
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Malonate
initial concentration: 1.0
is: CHEBI:30794
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_06831a5c_1c44_475b_80fc_153bf463d015
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
name: SLC26A1
is encoded by: hsa:10861

metaR OCDCAtr
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110048#
type: Reaction
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR FAOXC205C185m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM HC00460 c
name: 2,5-dihydroxybenzoate
type: Species
constant: false
is: CHEBI:58044
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628

metaM xoltriol c
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial concentration: 1.0
constant: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
type: Species
is: HMDB01457
has only substance units: false
is: CHEBI:16496
boundary condition: false
is: SBO:0000247

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR G14T6g
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
product: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
fast: false

metaR CYTK6
name: cytidylate kinase (CMP,CTP)
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110048#
modifier: MODEL1310110048#

metaM acnam c
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
name: N-acetylneuraminate
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:35418

metaR r2518
product: MODEL1310110048#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
fast: false
kinetic law: MODEL1310110048#
reversible: true
type: Reaction

metaM e4hglu m
name: erythro-4-hydroxy-L-glutamate(1-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: HMDB02273
is: CHEBI:6331
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

metaR AG13T8g
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110048#

metaM ala D e
initial amount: NaN
boundary condition: false
is: HMDB01310
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: CHEBI:15570
type: Species
constant: false
is: SBO:0000247
name: D-alanine

http://identifiers.org/biomodels.db/MODEL1310110048#_8e926711_37d9_420c_8f57_533ebb6a3cb7
is encoded by: hsa:248
type: Species
is: P09923
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ALPI
is: SBO:0000252

metaR r0596
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000000
product: MODEL1310110048#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
is: SBO:0000176
kinetic law: MODEL1310110048#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_487d7f7d_af9b_4333_b47a_b2f56df2a3a7
has only substance units: false
name: NDUFA13
initial concentration: NaN
type: Species
is: Q9P0J0
is: SBO:0000252
is encoded by: hsa:51079
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4aaa4349_f0f8_41c5_90a7_f3f12beea7a1
boundary condition: true
name: NME1
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:4830
has only substance units: false

metaM ksi pre9 g
initial concentration: 1.0
constant: false
is: HMDB00175
is: CHEBI:58053
initial amount: NaN
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 9
has only substance units: false
boundary condition: false
is: C00130
notes: FORMULA: C121H196N8O93S2X CHARGE: -3

metaR r1259
is described by: ECO:0000000
name: EC:6.2.1.3
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
reactant: MODEL1310110048#
reversible: false

metaR CYTK7
kinetic law: MODEL1310110048#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP)
type: Reaction
product: MODEL1310110048#

metaR HOMt4
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
modifier: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: L-homoserine via sodium symport
is described by: ECO:0000269
fast: false

metaM C04849 e
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate

metaR r1155
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
product: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
type: Reaction

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_9ad660c7_4fb9_40aa_9a18_89a67f6d3913
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:978
type: Species
name: CDA
initial amount: NaN
has only substance units: false
is: P32320

metaR PECTCHLe
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of pectins with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR PSt3
kinetic law: MODEL1310110048#
is: SBO:0000185
name: phosphatidylserine transport
is described by: ECO:0000269
product: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9174feed_0a70_4874_b939_bfc4e190b7f4
initial concentration: NaN
type: Species
is: SBO:0000252
name: _728637_1_c
is encoded by: hsa:728637
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r0731
kinetic law: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reversible: false
reactant: MODEL1310110048#
type: Reaction

metaR ALAyLATthc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM CE5132 n
is: CHEBI:57923
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM 2mp2coa m
has only substance units: false
name: 2-Methylprop-2-enoyl-CoA
boundary condition: false
is: CHEBI:27754
is: SBO:0000247
is: HMDB01011
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

metaM ksi pre33 g
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 33
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: C00130

metaR FRDPtcr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is described by: ECO:0000134
product: MODEL1310110048#
reversible: true
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaM 25aics c
initial amount: NaN
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: SBO:0000247
is: HMDB00797
boundary condition: false
type: Species
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
initial concentration: 1.0
has only substance units: false
constant: false
is: C04823
is: CHEBI:58443

metaR CYTK4
kinetic law: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
name: cytidylate kinase (dCMP)(GTP)
type: Reaction
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000269

metaR DNDPt19m
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269
name: dUDP transport via ATP antiport
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110048#
modifier: MODEL1310110048#

metaR CYSTGLUex
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
is: SBO:0000185
name: L-cystine/L-glutamate exchanger
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
type: Reaction
fast: false

metaM HC00250 c
type: Species
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
has only substance units: false
initial amount: NaN
name: hydrosulfide
is: CHEBI:29919
constant: false
initial concentration: 1.0

metaM gthrd c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
is: HMDB00125
name: Reduced glutathione
type: Species
has only substance units: false
is: C00051
is: CHEBI:57925

metaR r1154
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
name: EC:1.2.7.2
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:

metaM ascb L e
has only substance units: false
is: HMDB00044
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
name: L-ascorbate
is: SBO:0000247
is: CHEBI:38290

metaR r0365
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaR r0730
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110048#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110048#
type: Reaction
reversible: false
fast: false
is: SBO:0000176

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_8234fbbd_31ee_4470_aa8d_9c25e23ce230
type: Species
has only substance units: false
initial amount: NaN
is: B7Z792
is encoded by: hsa:4720
boundary condition: true
constant: false
initial concentration: NaN
name: NDUFS2
is: SBO:0000252

metaM prostgh2 r
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:57405
name: prostaglandin H2(1-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: HMDB01381

metaM gly c
is: HMDB00123
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
is: C00037
initial amount: NaN
constant: false
type: Species
is: CHEBI:3339
name: Glycine
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_7d090e60_f53f_4899_8ac4_d014c4006c8e
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PYCR2
is: Q96C36
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29920

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM CE4872 c
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
boundary condition: false
type: Species
is: CHEBI:15748
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00127
initial concentration: 1.0
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872

metaR r1988
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3c809dc1_bff6_4936_8921_fc68fe3c19fc
name: EHHADH
type: Species
is encoded by: hsa:1962
boundary condition: true
initial amount: NaN
is: Q9NY65
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR CYTK3
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP)(GTP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110048#
product: MODEL1310110048#

metaM HC02206 e
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57399
type: Species
name: prostaglandin C1(1-)

http://identifiers.org/biomodels.db/MODEL1310110048#_c1d2386b_147d_4afe_a235_730f30fb7347
is: P30838
is encoded by: hsa:218
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ALDH3A1
constant: false
type: Species

metaM HC01408 m
is: CHEBI:27648
type: Species
initial concentration: 1.0
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 3-Oxohexanoyl-CoA
boundary condition: false

metaR RE2626C
kinetic law: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
name: RE2626
fast: false

metaM frdp x
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
is: CHEBI:175763
name: farnesyl pyrophosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110048#_50947400_e030_4918_8930_2188c1cebf8c
boundary condition: true
is encoded by: hsa:85365
has only substance units: false
is: SBO:0000252
name: ALG2
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaR TRDR
reactant: MODEL1310110048#
name: thioredoxin reductase (NADPH)
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.9
is: SBO:0000176
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110048#_f9d20db8_f418_4bad_85f5_2f3cb2c6a12b
name: NT5C1B
boundary condition: true
constant: false
type: Species
is encoded by: hsa:93034
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q96P26
initial concentration: NaN

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaR MALtm
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000185
name: malate transport, mitochondrial
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
reversible: true
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_b62d7a55_f4b5_48e7_bb8b_15f54402579b
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P27987
type: Species
is: SBO:0000252
name: ITPKB
is encoded by: hsa:3707
has only substance units: false
constant: false

metaR r0660
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
kinetic law: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
fast: false
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110048#
reactant: MODEL1310110048#

metaR r2108
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_821ec927_aa73_406e_aa10_82076bd0caf8
is encoded by: hsa:276
is: SBO:0000252
has only substance units: false
name: AMY1A
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6NSB3

metaR FUM
type: Reaction
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110048#
name: fumarase
is version of: http://identifiers.org/ec-code/4.2.1.2
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
modifier: MODEL1310110048#

metaR r0733
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.12
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176

metaR GCALDD
fast: false
modifier: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
product: MODEL1310110048#
reversible: false
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction

metaM nadh x
is: CHEBI:57945
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
constant: false
is: HMDB01487
is: C00004
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaR FAOXTC162TC142m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_279a9f72_c071_4fb4_8c1c_6108229066e5
is: Q6P4B4
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5198
initial concentration: NaN
initial amount: NaN
name: PFAS
has only substance units: false

metaM HC00250 e
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:29919
name: hydrosulfide
constant: false
is: SBO:0000247
type: Species

metaR CYTK2
is described by: ECO:0000269
modifier: MODEL1310110048#
name: cytidylate kinase (dCMP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

metaM gthrd e
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
is: HMDB00125
name: glutathionate(1-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57925
constant: false
type: Species

metaM 2mbcoa m
initial amount: NaN
name: 2-methylbutanoyl-CoA(4-)
is: CHEBI:57336
constant: false
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01041
type: Species

metaR FATP3t
is: SBO:0000185
name: fatty acid electroneutral transport
product: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110048#_4b3ea19f_39c4_4801_bd85_790fe28cb114
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10841
name: FTCD
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O95954

metaR DNDPt11m
is described by: ECO:0000269
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
name: dADP transport via dGDP antiport
product: MODEL1310110048#
modifier: MODEL1310110048#

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR G3PD1
is described by: ECO:0000269
name: glycerol-3-phosphate dehydrogenase (NAD)
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.8
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176

metaR r0732
reversible: false
is described by: ECO:0000000
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110048#

metaM crn e
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
name: L-Carnitine
initial amount: NaN
type: Species
is: CHEBI:16347
is: HMDB00062
has only substance units: false
is: C00318
is: SBO:0000247
constant: false

metaR r2109
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR FERO
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
name: ferroxidase
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
reversible: false

metaM air c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C03373
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
constant: false
is: CHEBI:58592
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
type: Species
initial concentration: 1.0
is: HMDB01235
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_9edc4fb8_6039_4ba4_88bb_c38b1eb69075
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM ascb L c
type: Species
initial concentration: 1.0
is: CHEBI:38290
constant: false
is: HMDB00044
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: SBO:0000247
name: L-ascorbate
initial amount: NaN
boundary condition: false

metaR RE1845X
kinetic law: MODEL1310110048#
name: RE1845
product: MODEL1310110048#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
modifier: MODEL1310110048#
reactant: MODEL1310110048#

metaR CYTK1
name: cytidylate kinase (CMP)
is: SBO:0000176
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM m2emgacpail hs r
boundary condition: false
is: C00080
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
is: CHEBI:24636

metaR RE2541E
reactant: MODEL1310110048#
type: Reaction
fast: false
name: RE2541
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:

metaM h2o g
boundary condition: false
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: HMDB02111
is: CHEBI:15377
name: water

metaM HC00822 l
constant: false
is: CHEBI:28681
type: Species
initial amount: NaN
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
is: SBO:0000247
boundary condition: false
name: Chitobiose
has only substance units: false
initial concentration: 1.0

metaM 5mthf c
name: 5-Methyltetrahydrofolate
is: CHEBI:3729
is: HMDB01396
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00440
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
initial amount: NaN
type: Species

metaM fn2m2masn g
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
type: Species
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: CHEBI:32984
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9cb4bca2_09db_4307_af93_45f495bd56fd
constant: false
is encoded by: hsa:5321
initial concentration: NaN
has only substance units: false
is: P47712
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PLA2G4A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_285d9760_d89b_4cd2_8685_77f6516dc004
name: SLC1A5
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: Q15758
boundary condition: true
is encoded by: hsa:6510
type: Species

metaM 10fthf m
boundary condition: false
constant: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
initial amount: NaN
name: 10-formyltetrahydrofolate(2-)
type: Species
is: SBO:0000247
is: HMDB00972
initial concentration: 1.0

metaM h2o m
is: CHEBI:15377
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial concentration: 1.0
is: HMDB02111
is: C00001
name: H2O
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_4bc6e925_254c_481b_96c5_75e7c3555875
is: Q16878
name: CDO1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1036

http://identifiers.org/biomodels.db/MODEL1310110048#_560eeac7_d971_4b1e_8767_e5e84031982f
has only substance units: false
is: SBO:0000297
constant: false
initial concentration: NaN
initial amount: NaN
name: NME1:NME2
is encoded by: hsa:4830
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_743aec4d_f224_46e0_9c9c_d334488e9adf
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000297
initial concentration: NaN
name: PIGF:PIGG
type: Species
is encoded by: hsa:54872
has part: Q8NCI4

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM xol27oh m
name: 26-hydroxycholesterol
has only substance units: false
initial concentration: 1.0
is: CHEBI:17703
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02103
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340

metaR ALASERNaEx
product: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR r2106
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110048#
is described by: ECO:0000000
fast: false
type: Reaction

metaR r2038
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false

metaR r0735
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
product: MODEL1310110048#
is: SBO:0000176

metaM nadh r
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01487
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: CHEBI:57945
name: NADH(2-)
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaR PMEVKc
name: phosphomevalonate kinase, cytosol
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.2
is: SBO:0000176
reversible: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

metaM crn c
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:16347
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00062
boundary condition: false
is: C00318
name: L-Carnitine

metaR FAOXC15NADx
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nad)x
type: Reaction

metaM xoltriol m
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
is: CHEBI:16496
constant: false
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial concentration: 1.0
is: HMDB01457
boundary condition: false
initial amount: NaN

metaM hexdectecoa m
is: SBO:0000247
is: HMDB02288
has only substance units: false
name: 2,4,7,10-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_3bcbcb11_e574_4c7d_8404_e3017731c83d
initial concentration: NaN
is encoded by: hsa:122481
boundary condition: true
is: Q96M32
initial amount: NaN
has only substance units: false
name: AK7
type: Species
is: SBO:0000252
constant: false

metaM bamppald c
is: C05665
initial concentration: 1.0
constant: false
is: SBO:0000247
name: beta-Aminopropion aldehyde
is: http://identifiers.org/pubchem.compound/7975
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01106
type: Species

metaM acnam l
is: CHEBI:35418
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: N-acetylneuraminate
is: HMDB00230
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaM h2o n
boundary condition: false
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
constant: false
initial concentration: 1.0
has only substance units: false
name: water
type: Species
is: CHEBI:15377
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_8635f8c9_adcb_428f_903d_1b5367d5bfa9
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1633
is: SBO:0000252
is: P27707
name: DCK

http://identifiers.org/biomodels.db/MODEL1310110048#_0471cbc5_7ea2_43ee_a4c3_97dfdf50315d
type: Species
name: UGDH
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7358
constant: false
is: O60701
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM orot e
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
constant: false
name: orotate
boundary condition: false
is: CHEBI:30839
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00226

http://identifiers.org/biomodels.db/MODEL1310110048#_505e432a_faab_442b_9566_6b1ca9915c33
name: ENPP1
is: P22413
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:5167
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_c948730a_5ac1_4a22_b70d_a1bd50695ad6
is encoded by: hsa:56623
name: INPP5E
is: Q9NRR6
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false

metaR r0734
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110048#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_3adb759a_9a48_49b1_b4aa_3e56d7e83f64
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80025
constant: false
type: Species
is: Q6P1K9
has only substance units: false
initial amount: NaN
name: PANK2
boundary condition: true

metaR r2107
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r0009
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is: SBO:0000176
type: Reaction
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#

metaR r1464
is: SBO:0000185
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Active transport
fast: false
reversible: true
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_19a7bb27_db96_4b05_9bc6_bfb882aae0fa
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:4722
name: NDUFS3
constant: false
is: O75489
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_aa622673_283e_4bf1_9805_8f6cdd84b09e
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:54576
is: Q5DSZ6
initial amount: NaN
has only substance units: false
boundary condition: true
name: UGT1A8

metaM 5mthf e
is: CHEBI:3729
is: HMDB01396
constant: false
name: 5-Methyltetrahydrofolate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00440
boundary condition: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
type: Species

metaM pyr c
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00022
is: HMDB00243
type: Species
is: http://identifiers.org/pubchem.compound/3324
constant: false
is: CHEBI:15361
boundary condition: false

metaR DOLMANP Lter
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (liver)
product: MODEL1310110048#
reactant: MODEL1310110048#

metaR HSD3A2r
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: true
is described by: ECO:0000000
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3779e095_7a2b_4a5f_868b_8fd6a2e79235
name: PIK3C2G
is: O75747
has only substance units: false
initial amount: NaN
is encoded by: hsa:5288
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_424ede5b_8770_4234_8caf_dc0ca9c7d4b6
is encoded by: hsa:6508
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P48751
name: SLC4A3
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_8fc5f021_9671_433d_9e27_deb053504835
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:AD000092
name: _AD000092_1_c

metaM ksi pre8 g
initial concentration: 1.0
type: Species
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 8
is: CHEBI:28067
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_50ad180a_160d_4cd7_8cce_fc95eafb00ba
is: F8WDN9
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: PPA2
is encoded by: hsa:27068
is: SBO:0000252

metaR NAGLCAly
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
name: N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110048#
type: Reaction

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR GAMt1r
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
name: glucosamine transport (uniport)
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110048#

metaR F6Tg
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
name: glycoprotein 6-alpha-L-fucosyltransferase
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.68
product: MODEL1310110048#

metaR FUMtm
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
reversible: true
type: Reaction
product: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
is described by: ECO:0000269
name: fumarate transport, mitochondrial
reactant: MODEL1310110048#
fast: false

metaR VALTA
modifier: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
reversible: true
name: valine transaminase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
is: SBO:0000176

metaR r2104
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000

metaM mpdol U c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18396
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
boundary condition: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR ETF
is: SBO:0000176
name: electron transfer flavoprotein
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a4349817_80a4_4539_899a_b92bb2fdf6ba
is: SBO:0000252
boundary condition: true
name: SLC1A4
constant: false
initial concentration: NaN
initial amount: NaN
is: P43007
has only substance units: false
type: Species
is encoded by: hsa:6509

metaR BILIRUBt2
product: MODEL1310110048#
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110048#
type: Reaction
fast: false
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_c3808f96_88cd_43f0_8487_c57f730219f3
has only substance units: false
is encoded by: hsa:10166
name: SLC25A15
constant: false
type: Species
is: Q9Y619
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM dhcrm hs c
is: SBO:0000247
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
constant: false
has only substance units: false
type: Species
boundary condition: false
name: dihydroceramide
is: CHEBI:31488
initial amount: NaN
initial concentration: 1.0

metaR GLYCLTtp
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
name: glycolate transport into peroxisome
fast: false
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
is: SBO:0000185

metaM dhor S c
initial concentration: 1.0
boundary condition: false
is: CHEBI:30864
has only substance units: false
is: HMDB03349
is: SBO:0000247
type: Species
name: (S)-dihydroorotate
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial amount: NaN
constant: false

metaR r1156
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110048#

metaM h2o l
boundary condition: false
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02111
name: water
constant: false
type: Species
is: CHEBI:15377

metaM pail hs c
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
constant: false

metaR q10tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
name: transport of ubiquinone into mitochondria
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_4393e260_8715_4cb7_b479_d17ba6e52f9b
type: Species
constant: false
initial concentration: NaN
name: _H45672_1_m
is encoded by: hsa:H45672
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_feac5714_07d5_4b53_8e97_fe3c4e9cd79c
is encoded by: hsa:1581
initial amount: NaN
type: Species
is: SBO:0000252
is: P22680
constant: false
name: CYP7A1
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM g3p c
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3930
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:58027
constant: false
name: Glyceraldehyde 3-phosphate
is: SBO:0000247
is: C00661
is: HMDB01112
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116

http://identifiers.org/biomodels.db/MODEL1310110048#_868b8094_fb49_4525_9688_ba10a32c2238
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1178
boundary condition: true
is: SBO:0000252
name: CLC
initial amount: NaN
type: Species
is: C5HZ13

metaM pyr e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
is: CHEBI:15361

metaR r2105
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_cdc6ae0a_f88d_4cf9_94b2_eeeb72d3c3d8
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2678
name: GGT1
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaM sebacid c
initial concentration: 1.0
name: sebacicacid
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: C08277
notes: FORMULA: C10H16O4 CHARGE: -2
has only substance units: false
is: HMDB00792
initial amount: NaN

metaM orot c
is: SBO:0000247
is: HMDB00226
is: C00295
initial concentration: 1.0
name: Orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:30839

metaR r1747
type: Reaction
fast: false
kinetic law: MODEL1310110048#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000

metaR r2327
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110048#

metaM c226crn c
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: cervonyl carnitine
initial concentration: 1.0
type: Species
is: HMDB06510
is: http://identifiers.org/pubchem.compound/127055
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_3f90f99e_7153_488a_b66a_4f737f9091d5
name: SLC16A8
is encoded by: hsa:23539
constant: false
initial amount: NaN
initial concentration: NaN
is: O95907
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_874f8615_febb_4f0e_9dde_fd83574272ad
type: Species
boundary condition: true
initial amount: NaN
is: P30613
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PKLR
is encoded by: hsa:5313

metaR TCYNTt
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)

metaM hestratriol e
initial amount: NaN
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
has only substance units: false
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: 4,17 dihydroxy estradiol
is: HMDB05896
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_2590443b_4f9b_4df4_8591_9ee59ac23de1
name: DGKD
is: Q16760
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8527
type: Species
has only substance units: false
boundary condition: true

metaR PRFGS
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.5.3
name: phosphoribosylformylglycinamidine synthase
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ac1a9904_2743_4640_a65c_f518ece9d90b
is: SBO:0000252
initial amount: NaN
is: F5H2Y9
name: ALDH1A2
constant: false
is encoded by: hsa:8854
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_8f024dd1_f25b_4701_a431_d57d688fc207
name: _22305_2_c
is: SBO:0000252
is encoded by: hsa:22305
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR HEX7
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110048#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-fructose:ATP)

metaR EHGLATm
reactant: MODEL1310110048#
product: MODEL1310110048#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: false
is described by: ECO:0000212
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110048#
is: SBO:0000176
type: Reaction
fast: false

metaR ACACt2m
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000269
reversible: true
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction

metaR UDPGALtg
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
name: UDP-Gal Golgi transport via CMP antiport
type: Reaction
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110048#

metaR PRPPS
modifier: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: phosphoribosylpyrophosphate synthetase
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.6.1
fast: false

metaR DOLMANP Uter
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
name: dolichol-phosphate mannose flippase (uterus)
reversible: false
type: Reaction
fast: false

metaR r1575
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_d5e758e3_9294_4e8c_b8fa_662273626340
is: Q99808
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC29A1
is encoded by: hsa:2030

metaR r0666
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
modifier: MODEL1310110048#

metaR r2326
reactant: MODEL1310110048#
fast: false
is: SBO:0000185
product: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction

metaM xol27oh r
is: HMDB02103
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: CHEBI:17703
name: 26-hydroxycholesterol
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaR SARCStex
type: Reaction
reactant: MODEL1310110048#
name: Sarcosine transport (extracellular to cytosol)
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
fast: false
reversible: false

metaM pail3p hs n
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
constant: false
is: CHEBI:58088
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_4fd0004b_0e34_4f55_83b6_280a2bce5055
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2348
type: Species
initial concentration: NaN
name: FOLR1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_432c0684_5dbb_4928_a041_2cbdc3a8f203
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: UROC1
has only substance units: false
type: Species
is: Q68CJ7
constant: false
is encoded by: hsa:131669
is: SBO:0000252

metaM anth e
type: Species
initial amount: NaN
is: HMDB01123
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
constant: false
name: anthranilate
is: CHEBI:16567

metaM pchol hs r
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:16110
name: Phosphatidylcholine
boundary condition: false
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
constant: false
initial concentration: 1.0

metaM HC02180 c
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: thromboxane-b2
constant: false
is: CHEBI:28728

http://identifiers.org/biomodels.db/MODEL1310110048#_bda2f02b_986a_4e4b_b812_9a6d15f266d0
is: SBO:0000252
initial amount: NaN
is: P30048
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:10935
constant: false
name: PRDX3

metaR VALTAm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110048#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: valine transaminase, mitochondiral
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110048#

metaR r1574
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110048#
reversible: true

metaM hestratriol c
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: 4,17 dihydroxy estradiol
type: Species
initial concentration: 1.0
is: HMDB05896
has only substance units: false

metaR r1749
reversible: false
modifier: MODEL1310110048#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

metaR r0668
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110048#
fast: false
type: Reaction
modifier: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.19
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaM xylu D c
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:17140
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
name: D-xylulose
type: Species
is: HMDB01644
boundary condition: false

metaR r0097
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
product: MODEL1310110048#

metaR FAOXC101C102m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaM gthox m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:58297
is: HMDB03337
boundary condition: false
type: Species
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial amount: NaN
constant: false

metaR r1573
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000

metaR r2329
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is: SBO:0000185
reversible: true
reactant: MODEL1310110048#
fast: false

metaR r0475
reactant: MODEL1310110048#
fast: false
type: Reaction
reversible: true
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR SERCYSNaEx
product: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_3bdd235f_022b_4937_b135_4c043fa777c7
has part: P55084
initial concentration: NaN
constant: false
has part: E9KL44
name: HADHA:HADHB
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:3030
is encoded by: hsa:3032
is: SBO:0000297

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_6364f3fe_381b_4092_b9c3_d47524164184
is encoded by: hsa:23533
type: Species
initial concentration: NaN
is: Q8WYR1
has only substance units: false
name: PIK3R5
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM urate e
boundary condition: false
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
type: Species
has only substance units: false
is: C00366
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00289
name: Urate
constant: false

metaR HEX4
type: Reaction
name: hexokinase (D-mannose:ATP)
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is version of: http://identifiers.org/ec-code/2.7.1.1

metaR 5MTHFt
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
product: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is: SBO:0000185
reversible: true
reactant: MODEL1310110048#

metaR GLYt7 311 r
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
is: SBO:0000185
is described by: ECO:0000006
reversible: true
name: glycine reversible transport via sodium and chloride symport (3:1:1)

http://identifiers.org/biomodels.db/MODEL1310110048#_00002946_b953_482c_8a73_0f7629f71a8a
initial amount: NaN
is encoded by: hsa:1340
initial concentration: NaN
has only substance units: false
name: COX6B1
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: P14854

metaM glu L e
constant: false
is: CHEBI:29985
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
name: L-glutamate(1-)
has only substance units: false
is: HMDB00148
boundary condition: false

metaM anth c
is: CHEBI:16567
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01123
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
name: anthranilate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_0b1dc50d_2f94_47ca_a525_0a4b522c2574
name: NDUFB10
is: SBO:0000252
constant: false
is: A8K761
initial concentration: NaN
is encoded by: hsa:4716
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaM HC02180 e
has only substance units: false
constant: false
is: CHEBI:28728
name: thromboxane-b2
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM gthrd m
initial concentration: 1.0
is: CHEBI:57925
boundary condition: false
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
name: glutathionate(1-)
is: HMDB00125
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM acnam n
type: Species
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:35418
boundary condition: false
is: HMDB00230
initial concentration: 1.0
has only substance units: false

metaR r1260
name: EC:6.2.1.3
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_9ad5dacc_aa79_4f28_b16b_dac810a2f2e0
is: SBO:0000252
constant: false
boundary condition: true
is: P24752
has only substance units: false
name: ACAT1
is encoded by: hsa:38
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_51be51f0_fa85_4d13_819e_9ffdb9961912
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: _AI620219_1_e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI620219

http://identifiers.org/biomodels.db/MODEL1310110048#_78f34854_84d4_41b4_9de0_fe789eae01b7
is encoded by: hsa:249
type: Species
constant: false
name: ALPL
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: B7Z4Y6
has only substance units: false

metaR r1639
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
reversible: true
kinetic law: MODEL1310110048#

metaR RETFA
type: Reaction
reversible: false
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110048#
fast: false
name: retinol acyltransferase
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110048#_444557f7_3b9b_4444_ad53_3a907a66d4a6
constant: false
is encoded by: hsa:C7orf24
is: SBO:0000252
name: _C7orf24_1_m
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r2323
reactant: MODEL1310110048#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_de3a0a09_78be_4ef9_8a77_3661b5515d7f
initial amount: NaN
is: P21399
name: ACO1
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:48

metaM andrstrn r
constant: false
is: HMDB00031
has only substance units: false
boundary condition: false
name: androsterone
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial concentration: 1.0
type: Species
is: CHEBI:16032

metaR r1579
fast: false
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ALDD2x
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
name: aldehyde dehydrogenase (acetaldehyde, NAD)
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110048#
type: Reaction

metaR PMANM
is version of: http://identifiers.org/ec-code/5.4.2.8
is described by: ECO:0000000
reversible: true
name: phosphomannomutase
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/5.4.2.2
fast: false
product: MODEL1310110048#

metaR GMPtg
reactant: MODEL1310110048#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
is: SBO:0000185
is described by: ECO:0000269
name: GMP transport (Golgi)
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaR SEBCOACROT
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR r0002
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000185
name: Active transport
fast: false
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110048#
reversible: true

metaR FUCASEe
product: MODEL1310110048#
fast: false
is described by: ECO:0000000
type: Reaction
name: alpha-fucosidase, extracellular
reactant: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110048#_213905ac_0913_4974_9ad9_55bf27377b67
has only substance units: false
is encoded by: hsa:5740
name: PTGIS
is: SBO:0000252
is: Q16647
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR r1400
type: Reaction
product: MODEL1310110048#
name: Active transport
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_70a36f2e_1af5_49d8_8e88_1ed21a809453
boundary condition: true
is: Q9NRA2
is: SBO:0000252
is encoded by: hsa:26503
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: SLC17A5

metaR TREHe
is version of: http://identifiers.org/ec-code/3.2.1.28
modifier: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
product: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000269
fast: false
name: alpha,alpha-trehalase
reactant: MODEL1310110048#

metaR r1374
type: Reaction
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
reactant: MODEL1310110048#
is described by: ECO:0000000
name: EC:3.2.1.14
kinetic law: MODEL1310110048#
is: SBO:0000176
reversible: false

metaM ksii core4 pre2 g
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: C00130
constant: false
initial concentration: 1.0
is: HMDB00175
name: keratan sulfate II boisynthesis, precursor 2
has only substance units: false
is: CHEBI:58053
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_f67fd265_596e_4607_9c6c_043b95f66416
has only substance units: false
is: SBO:0000252
constant: false
is: Q9NS82
initial concentration: NaN
is encoded by: hsa:56301
boundary condition: true
type: Species
initial amount: NaN
name: SLC7A10

metaR NACHEXA21ly
is: SBO:0000176
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110048#_7d956a03_23e1_4033_9048_481fb421eeda
initial amount: NaN
boundary condition: true
is encoded by: hsa:8611
type: Species
is: G3XA95
constant: false
initial concentration: NaN
is: SBO:0000252
name: PPAP2A
has only substance units: false

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM h2o e
has only substance units: false
is: C00001
name: H2O
boundary condition: false
is: CHEBI:15377
initial concentration: 1.0
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: SBO:0000247
is: HMDB02111
initial amount: NaN

metaM prostgh2 e
initial concentration: 1.0
is: CHEBI:57405
is: SBO:0000247
initial amount: NaN
is: HMDB01381
boundary condition: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
has only substance units: false
name: prostaglandin H2(1-)

metaR PA HStn
is described by: ECO:0000000
name: phosphatidate transport, nuclear
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185

metaM tchola x
is: SBO:0000247
boundary condition: false
is: CHEBI:36257
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
initial amount: NaN
initial concentration: 1.0
name: taurocholate
constant: false
has only substance units: false

metaR FAOXC11
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
is: SBO:0000176
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid

metaM dcamp c
type: Species
initial concentration: 1.0
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: HMDB00536
initial amount: NaN
constant: false
is: C03794
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57567
name: N6-(1,2-Dicarboxyethyl)-AMP

http://identifiers.org/biomodels.db/MODEL1310110048#_c06a899d_1426_4ff5_bf70_abc1b1cf0922
constant: false
boundary condition: true
is encoded by: hsa:AA629629
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: _AA629629_1_m
initial concentration: NaN

metaM urate c
is: C00366
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00289
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
constant: false
is: CHEBI:17775
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_1be7ba47_514d_4bf3_a398_78fbe5dc0154
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: _LOC728997_1_c
constant: false
is encoded by: hsa:LOC728997
initial concentration: NaN

metaR UDPDOLPT U
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
reactant: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.117
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR r2322
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
product: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r0474
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_6b522f9a_798a_44ee_a10b_6b4c30d30302
is: O95167
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: NDUFA3
has only substance units: false
is encoded by: hsa:4696
type: Species
initial amount: NaN

metaR ALDD2y
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: aldehyde dehydrogenase (acetaldehyde, NADP)

metaR r1578
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_3dfdd1d0_0264_41a6_82df_29e011042658
constant: false
is: O95299
has only substance units: false
is encoded by: hsa:4705
type: Species
initial concentration: NaN
name: NDUFA10
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM glu L c
is: SBO:0000247
is: CHEBI:29985
name: L-glutamate(1-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00148
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaR S6T12g
reactant: MODEL1310110048#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
product: MODEL1310110048#
type: Reaction
reversible: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110048#
is described by: ECO:0000000

metaM dcsptn1crn c
is: SBO:0000247
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
constant: false
is: HMDB06321
has only substance units: false
initial amount: NaN
type: Species
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false

metaR ASNTHRNaEx
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110048#
reversible: false
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_bd7daab4_6e05_4e7e_a1d8_a9c063686afe
initial amount: NaN
constant: false
name: STS
type: Species
is encoded by: hsa:412
boundary condition: true
is: SBO:0000252
is: P08842
initial concentration: NaN
has only substance units: false

metaR r1375
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110048#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
reactant: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_aa5c92b2_c633_48bf_b533_bf3c31f97ac2
is encoded by: hsa:7083
is: P04183
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: TK1
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_6b648564_a03f_4139_89ce_bcf757b4642b
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GMPR2
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9P2T1
is encoded by: hsa:51292
constant: false

metaR r1637
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_3c000549_2d57_4597_ae1a_45bca7737861
constant: false
initial concentration: NaN
is encoded by: hsa:1543
initial amount: NaN
boundary condition: true
name: CYP1A1
has only substance units: false
is: SBO:0000252
type: Species
is: A0N0X8

http://identifiers.org/biomodels.db/MODEL1310110048#_2b9bf7f7_6a43_4289_aa51_d6433c9b798f
is: SBO:0000252
is encoded by: hsa:80055
initial amount: NaN
type: Species
name: PGAP1
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: Q75T13

http://identifiers.org/biomodels.db/MODEL1310110048#_00aabe43_3561_407a_903f_75003f5ce163
name: NDUFAB1
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: O14561
is encoded by: hsa:4706
is: SBO:0000252
constant: false

metaR r2325
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110048#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
product: MODEL1310110048#
is: SBO:0000185

metaR A MANASEly
type: Reaction
name: alpha-mannosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.24
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_73320928_ff90_4bae_8b15_2c179781fc83
boundary condition: true
is: Q6FG42
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: NDUFA7
is encoded by: hsa:4701
has only substance units: false
constant: false

metaR DADNt4
product: MODEL1310110048#
name: deoxyadenosine transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false

metaM CE1926 e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: gama-carboxyethyl-hydroxychroman
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15748
constant: false
is: HMDB00127
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926

http://identifiers.org/biomodels.db/MODEL1310110048#_bfceb89b_0a92_4b6c_9429_1d5481f3791b
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PLCD3
is: Q8N3E9
boundary condition: true
is encoded by: hsa:113026

metaR FADH2tru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
product: MODEL1310110048#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
name: FADH2 transporter, endoplasmic reticulum

metaM T antigen g
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: T antigen (core 1)
boundary condition: false
constant: false
type: Species
is: CHEBI:22783
initial amount: NaN
notes: FORMULA: C14H24NO10X CHARGE: 0

metaM h2o c
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3303
is: HMDB02111
has only substance units: false
notes: FORMULA: H2O CHARGE: 0
boundary condition: false
is: C00001
name: H2O

metaM lnlncgcoa c
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial amount: NaN
has only substance units: false
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
type: Species
is: SBO:0000247
is: HMDB06368
initial concentration: 1.0
boundary condition: false
constant: false

metaM HC02206 c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
is: SBO:0000247
is: CHEBI:57399
name: prostaglandin C1(1-)
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_e9423441_b194_4aae_b1fb_6057af060854
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: NDUFB8
is: SBO:0000252
is encoded by: hsa:4714
initial concentration: NaN
is: O95169
boundary condition: true

metaM ksii core4 pre8 g
is: SBO:0000247
type: Species
notes: FORMULA: C83H134N7O61SX CHARGE: -2
boundary condition: false
is: C00130
initial amount: NaN
is: HMDB00175
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 8
constant: false
is: CHEBI:58053
initial concentration: 1.0

metaR r1638
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110048#
reversible: true

metaR r2324
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR LEUKTRB4t
name: leukotriene B4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#
is described by: ECO:0000000
fast: false

metaR DURAD
kinetic law: MODEL1310110048#
name: dihydrouracil dehydrogenase (NADP)
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
modifier: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_00b19a50_9942_4cc7_952f_13669f96be41
is encoded by: hsa:8395
name: PIP5K1B
is: O14986
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaR r1576
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6ec0af8b_9d4e_432a_a52e_d66d6887d1f8
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O95139
initial amount: NaN
is encoded by: hsa:4712
name: NDUFB6
is: SBO:0000252

metaR r0472
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaM gly e
name: Glycine
is: HMDB00123
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:3339
is: C00037
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110048#_bf2d20b6_c361_4166_a797_5487bd547796
is: Q53Y25
boundary condition: true
type: Species
is encoded by: hsa:2645
initial amount: NaN
constant: false
name: GCK
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_8443d16a_8843_4045_b1cc_4e22e696a40c
name: B4GALT1
initial concentration: NaN
is encoded by: hsa:2683
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: P15291

metaR r1377
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110048#_f55cd7a9_0396_42d9_93c3_a716a6f55932
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1608
type: Species
constant: false
name: DGKG
initial amount: NaN
is: P49619
boundary condition: true
is: SBO:0000252

metaM occoa c
constant: false
is: CHEBI:57386
is: C01944
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)
is: HMDB01070
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9ed9475e_3227_468c_8358_5cb7e255b6e6
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q9H6Y6
is encoded by: hsa:4645
initial amount: NaN
name: MYO5B
initial concentration: NaN

metaM acgam r
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
is: CHEBI:17411
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00215
is: SBO:0000247
name: N-acetyl-D-glucosamine
constant: false

metaM nh4 e
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: ammonium
constant: false
is: SBO:0000247
is: HMDB00051
type: Species
is: CHEBI:28938
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR GULNter
name: L-gulonate endoplasmic reticular export
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110048#
reversible: false

metaM lnlncgcoa r
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial amount: NaN
has only substance units: false
is: CHEBI:57363
initial concentration: 1.0
is: HMDB06368
boundary condition: false
type: Species
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
constant: false

metaR FACOAL181i
is: SBO:0000176
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
name: C181 fatty acid activation
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110048#
type: Reaction
reversible: false

metaR r0584
reactant: MODEL1310110048#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
product: MODEL1310110048#

metaR RE3520E
modifier: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.9
name: RE3520
kinetic law: MODEL1310110048#

metaM bildglcur c
name: bis(beta-glucosyluronate)bilirubin
constant: false
has only substance units: false
is: CHEBI:58471
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03325
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

http://identifiers.org/biomodels.db/MODEL1310110048#_0df0337d_ecfc_4c25_8c5a_b994d700dea2
is: Q10471
has only substance units: false
is: SBO:0000252
name: GALNT2
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:2590
constant: false

metaM uri c
is: HMDB00296
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
is: C00299
initial amount: NaN
is: SBO:0000247
is: CHEBI:16704
name: Uridine
boundary condition: false
has only substance units: false

metaR r2334
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1604
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reversible: true

metaR H2CO3D
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
name: carboxylic acid dissociation
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
type: Reaction

metaM glcur e
constant: false
initial concentration: 1.0
is: SBO:0000247
name: D-glucuronate
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
is: HMDB00127
has only substance units: false
type: Species
boundary condition: false

metaM itacon m
is: CHEBI:17240
is: HMDB02092
name: itaconate(2-)
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
has only substance units: false

metaR r2120
reversible: true
modifier: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110048#
type: Reaction

metaR r2434
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR DOLPMT U
type: Reaction
is: SBO:0000176
reversible: false
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
is described by: ECO:0000000
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.83
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_422f9750_1626_4a88_a80c_316513f8ce36
has only substance units: false
is: P49189
initial concentration: NaN
is encoded by: hsa:223
constant: false
boundary condition: true
name: ALDH9A1
initial amount: NaN
is: SBO:0000252
type: Species

metaM btn e
type: Species
initial amount: NaN
is: HMDB00030
is: SBO:0000247
boundary condition: false
is: CHEBI:3420
initial concentration: 1.0
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
is: C00120
has only substance units: false

metaM met L e
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: CHEBI:16643
initial amount: NaN
has only substance units: false
is: HMDB00696
name: L-methionine
boundary condition: false

metaR r0698
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.2.27
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_5623a3b9_e820_4262_ba80_5f36a183928a
has only substance units: false
name: UAP1
type: Species
boundary condition: true
is: Q16222
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6675
constant: false

metaR r2335
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110048#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

metaR H7ET2er
product: MODEL1310110048#
type: Reaction
reversible: false
reactant: MODEL1310110048#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
is: SBO:0000176
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.8.1

metaR r0717
reactant: MODEL1310110048#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110048#

metaR r1603
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksi pre18 g
initial amount: NaN
is: CHEBI:58053
type: Species
is: C00130
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
initial concentration: 1.0
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 18
boundary condition: false
constant: false
is: SBO:0000247

metaR ACHEe
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.1.7
type: Reaction
name: Acetylcholinesterase
reversible: false
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#

metaR r2121
product: MODEL1310110048#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110048#_2164e048_7d73_452a_bbff_3a6ae902c0bc
type: Species
constant: false
boundary condition: true
has only substance units: false
is: P48735
name: IDH2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3418
initial amount: NaN

metaR ETOHt
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
reversible: true
name: ethanol reversible transport
kinetic law: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_fa557661_3d7f_4394_9dee_d388fc7edc4f
constant: false
is: Q4J699
type: Species
has only substance units: false
is encoded by: hsa:491
boundary condition: true
name: ATP2B2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM nh4 c
initial amount: NaN
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:28938
is: C01342
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_b716452f_744f_40b6_85d0_eca0eb77dbf5
constant: false
has only substance units: false
type: Species
is: O43708
is encoded by: hsa:2954
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: GSTZ1

metaR S6T14g
reversible: false
modifier: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110048#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#

metaM pi x
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:43474
name: hydrogenphosphate
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
constant: false

metaM ttetddcoa m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: trans5,8tetradecadienoylcoa
is: HMDB02288
is: SBO:0000247
has only substance units: false

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR RE3628M
kinetic law: MODEL1310110048#
name: RE3628
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110048#

metaR RE0944E
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
name: RE0944
reactant: MODEL1310110048#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_78b9af50_483e_4613_a028_b468a53f4786
has only substance units: false
initial amount: NaN
is encoded by: hsa:6319
is: SBO:0000252
name: SCD
type: Species
initial concentration: NaN
is: O00767
constant: false
boundary condition: true

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM uri e
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
is: C00299
is: HMDB00296
name: Uridine
constant: false
boundary condition: false
is: CHEBI:16704
type: Species
has only substance units: false
is: SBO:0000247

metaR r0618
type: Reaction
product: MODEL1310110048#
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaM xoltetrol m
type: Species
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
constant: false
is: SBO:0000247
is: HMDB01231
is: CHEBI:17278
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

metaR r1538
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
product: MODEL1310110048#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110048#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r1602
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110048#
reversible: true

metaM nicrnt c
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:57502
name: Nicotinate D-ribonucleotide
is: HMDB01132
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: C01185

metaR ORNALArBATtc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaM met L c
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: L-methionine
boundary condition: false
initial amount: NaN
is: HMDB00696
is: CHEBI:16643

metaM datp n
initial amount: NaN
is: CHEBI:61404
name: dATP
constant: false
is: HMDB01532
is: C00131
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

metaR r2122
modifier: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reversible: true
product: MODEL1310110048#
is: SBO:0000185

metaR GLCURter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110048#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000185
name: glucuronate endoplasmic reticular transport

metaR CITtam
modifier: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
fast: false
name: citrate transport, mitochondrial
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaM h2o2 m
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
is: CHEBI:16240
is: C00027
initial concentration: 1.0
type: Species
name: Hydrogen peroxide
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaM cys L c
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
name: L-cysteine
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:17561
is: HMDB00574
initial amount: NaN
has only substance units: false

metaR PItx
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110048#
name: Phosphate transporter, peroxisome
fast: false

metaM hco3 c
is: CHEBI:17544
is: C00288
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Bicarbonate

http://identifiers.org/biomodels.db/MODEL1310110048#_753c66ba_e3f5_4433_8391_168bb6d5175d
is encoded by: hsa:55343
constant: false
name: SLC35C1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: B3KQH0

http://identifiers.org/biomodels.db/MODEL1310110048#_91cc109e_cc29_4cca_921d_619d621ec0d5
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4705
name: NDUFA10
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O95299

http://identifiers.org/biomodels.db/MODEL1310110048#_0ec4b1b6_328e_4621_86c5_9fca6abdb435
is: D3DX95
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1103
name: CHAT
constant: false
is: SBO:0000252

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR GTHDH
reactant: MODEL1310110048#
is described by: ECO:0000134
name: Glutathione dehydrogenase (dehydroascorbate reductase)
product: MODEL1310110048#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
reversible: false
kinetic law: MODEL1310110048#

metaM pnto R c
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
has only substance units: false
is: HMDB00210
boundary condition: false
is: SBO:0000247
is: CHEBI:7916
type: Species
name: (R)-Pantothenate
initial concentration: 1.0
constant: false

metaR r0587
is described by: ECO:0000000
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
product: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction

metaM CE4876 r
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
initial amount: NaN
name: delta12-Prostaglandin J2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
has only substance units: false
type: Species
constant: false

metaR FAOXMC10OHMC10r
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(MC10-->w-OHMC10)er
type: Reaction

metaR r0617
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
reversible: true
type: Reaction
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_22d12ab0_b246_407b_8c48_946687726bf9
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: MAOA
initial concentration: NaN
is: Q53YE7
is encoded by: hsa:4128
type: Species
constant: false

metaR RE1804C
fast: false
type: Reaction
reactant: MODEL1310110048#
reversible: true
name: RE1804
is: SBO:0000176
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR r0504
reversible: true
product: MODEL1310110048#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000

metaR XYLK
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9942.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.17 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.17
name: xylulokinase
product: MODEL1310110048#
fast: false
is: SBO:0000176

metaR r0715
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.2.5
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176

metaR MM7Cbg
kinetic law: MODEL1310110048#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110048#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110048#
type: Reaction

metaR r2123
product: MODEL1310110048#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_3190752d_d00c_481b_b9d6_4b8cc767439b
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: E2QRH8
has only substance units: false
type: Species
name: PLCB4
constant: false
is encoded by: hsa:5332

http://identifiers.org/biomodels.db/MODEL1310110048#_97ea88ea_86b4_4db9_a539_74ce61a4cb53
name: PRPS1L1
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:221823
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR DCATDc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the cell by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_1878a23b_f053_41aa_9d3e_ba8d444b5724
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _AI090874_1_c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI090874
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_19ae0aaf_c7f2_4a7a_af77_bd18681776fb
type: Species
name: ACSS2
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q5QPH3
is encoded by: hsa:55902
initial concentration: NaN
boundary condition: true
constant: false

metaR HXPRT
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: false
is described by: ECO:0000269
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#

metaM 13 cis retn r
is: D00348
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial amount: NaN
name: 13-cis-retinoate
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB06219
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7847414

metaM dmnoncrn x
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06202

metaR r2437
type: Reaction
kinetic law: MODEL1310110048#
reversible: false
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_198befa3_46c3_4e86_9eff_1bf45656b2e5
is: Q8NEB9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: PIK3C3
is encoded by: hsa:5289
initial amount: NaN
constant: false
has only substance units: false

metaM pi r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
is: C00009
name: hydrogenphosphate
boundary condition: false
is: HMDB00973
initial amount: NaN
is: CHEBI:43474
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_9b1bcf8b_36cd_4b77_a018_24c088bff746
is encoded by: hsa:126328
name: NDUFA11
initial concentration: NaN
is: C9JT23
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR r0580
kinetic law: MODEL1310110048#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.7
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30

http://identifiers.org/biomodels.db/MODEL1310110048#_2188f01a_8818_4d50_8a3b_52b6fd74cfd1
is encoded by: hsa:259230
has only substance units: false
name: SGMS1
initial amount: NaN
initial concentration: NaN
is: D3DWC4
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaR EICOSTETt
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_5e46c08c_6d97_4a69_b087_76b8b729f8ed
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q02318
is encoded by: hsa:1593
type: Species
initial amount: NaN
name: CYP27A1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d4cfaf21_1f13_4a87_9472_cfd1900a941b
boundary condition: true
initial amount: NaN
constant: false
name: INPPL1
is: SBO:0000252
has only substance units: false
is: O15357
initial concentration: NaN
is encoded by: hsa:3636
type: Species

metaR RE1518M
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110048#
fast: false
name: RE1518
product: MODEL1310110048#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM guln r
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
name: L-gulonate
is: HMDB03290
is: CHEBI:13115
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_27c43954_b25a_4c90_85a5_d147fad18d47
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:51809
has only substance units: false
is: Q86SF2
name: GALNT7
is: SBO:0000252

metaM 3dodtricoa m
is: SBO:0000247
initial amount: NaN
constant: false
is: C05280
initial concentration: 1.0
type: Species
name: 3,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: HMDB03952
has only substance units: false
boundary condition: false

metaR r1608
is: SBO:0000185
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2338
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reversible: true
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:

metaR r1758
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#

metaR FADDPle
reversible: false
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
name: FAD diphosphatase
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000134

metaR r2124
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110048#
fast: false
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_ee6ab063_9068_4b23_a86e_bc77aac0af39
name: SLC35D1
constant: false
is encoded by: hsa:23169
type: Species
initial amount: NaN
is: Q9NTN3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR GDPtg
reactant: MODEL1310110048#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: GDP intracellular transport
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
type: Reaction
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_0114027e_1cf0_4c6a_bd42_c2e20b3732e7
type: Species
initial concentration: NaN
is: SBO:0000252
name: _BG035985_1_c
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:BG035985
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_1655acba_74d3_4da3_9dca_1780aa753147
initial concentration: NaN
name: _AA081045_1_m
initial amount: NaN
constant: false
is encoded by: hsa:AA081045
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaM sph1p c
is: CHEBI:57939
constant: false
is: HMDB01383
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

metaM dttp e
is: HMDB01342
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
constant: false
name: dTTP(4-)
is: CHEBI:37568

metaR GCC2am
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
kinetic law: MODEL1310110048#
name: glycine-cleavage complex (lipoamide), mitochondrial
fast: false
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110048#
reversible: true

metaR ST8SIA12
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.99.8
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
fast: false
modifier: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase

metaM pnto R e
initial concentration: 1.0
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
type: Species
is: HMDB00210
is: CHEBI:7916
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: (R)-Pantothenate
initial amount: NaN

metaR DCMPDA
is version of: http://identifiers.org/ec-code/3.5.4.12
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000254
reversible: true
name: dCMP deaminase
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110048#_0f255d60_4b9e_4883_89a0_b23bb959a1d2
is: Q8NFF5
is encoded by: hsa:80308
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: FLAD1
initial amount: NaN
boundary condition: true

metaR r0196
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110048#
is: SBO:0000176
fast: false
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_9f869487_945c_4707_83de_ece0d1e05606
is: P30084
type: Species
is encoded by: hsa:1892
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: ECHS1
is: SBO:0000252
boundary condition: true

metaR GASNASE2ly
name: glycosylasparaginase, lysosomal
fast: false
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_158a8d90_0303_48d3_a79f_909503c8a7c6
has only substance units: false
type: Species
name: DHODH
is: SBO:0000252
is encoded by: hsa:1723
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: Q02127

metaM retinol cis 11 c
has only substance units: false
is: CHEBI:16302
is: HMDB06216
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 11-cis-retinol
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

http://identifiers.org/biomodels.db/MODEL1310110048#_982e5d1f_933a_4675_80f7_0b99d1fee1ab
initial concentration: NaN
boundary condition: true
constant: false
name: _AI222095_1_m
is encoded by: hsa:AI222095
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r2125
is: SBO:0000185
product: MODEL1310110048#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000000

metaM bhb m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
is: HMDB00011
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaR r1607
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r0502
reversible: true
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_247b209d_3ff7_41de_a9f9_af1cc3635c2e
has only substance units: false
name: NDUFB2
type: Species
is: H7C5B8
is encoded by: hsa:4708
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaM lnlncg c
constant: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
has only substance units: false
is: HMDB03073
is: SBO:0000247
initial amount: NaN
name: gamma-linolenate
initial concentration: 1.0
boundary condition: false

metaM fum m
initial amount: NaN
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
boundary condition: false
constant: false
is: C00122
has only substance units: false
name: Fumarate
is: CHEBI:29806
is: HMDB00134
initial concentration: 1.0
is: SBO:0000247

metaR BILDGLCURt
is: SBO:0000185
type: Reaction
reversible: true
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110048#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaR MM5ag
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
modifier: MODEL1310110048#
reversible: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176

metaM sucsal m
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
has only substance units: false
is: HMDB01259
boundary condition: false
name: Succinic semialdehyde
is: CHEBI:57706
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_88db52fc_efbd_43f5_a318_22e4605d9c0f
initial amount: NaN
has only substance units: false
constant: false
name: CPT2
is encoded by: hsa:1376
is: P23786
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaR PTE3x
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is: SBO:0000176
product: MODEL1310110048#
name: peroxisomal acyl-CoA thioesterase
fast: false

metaR M8MASNterg
reversible: false
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185
name: m8masn transport from ER to Golgi apparatus
fast: false
kinetic law: MODEL1310110048#

metaM pep m
constant: false
name: Phosphoenolpyruvate
is: CHEBI:18021
initial concentration: 1.0
type: Species
is: HMDB00263
is: C00074
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r2435
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
reversible: false
type: Reaction
fast: false
product: MODEL1310110048#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_f4b61cdc_ca3e_404d_89f6_36549d1b0e72
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:6513
is: SBO:0000252
is: P11166
name: SLC2A1
constant: false
initial concentration: NaN

metaR BHBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reversible: true
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_a7425ca7_35d7_4b92_9ae2_8ddebc8a1acc
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: PANK3
has only substance units: false
is: Q9H999
is: SBO:0000252
is encoded by: hsa:79646
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_60fe8145_9060_48da_9673_121eb8ae7e74
name: CPT1B
initial amount: NaN
is encoded by: hsa:1375
is: Q92523
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_9b62ab7f_924c_4706_9a80_1d8cc30de49d
boundary condition: true
initial concentration: NaN
name: SLC25A4
is: P12235
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:291
constant: false

metaM glcur c
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
has only substance units: false
boundary condition: false
is: HMDB00127
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110048#_ddca267e_5ae1_4587_9c5b_20194632cd5a
constant: false
name: PLD2
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5338
is: O14939
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_e90d3507_dc8e_4a10_9b6b_214c5064058c
is: SBO:0000252
name: DDC
boundary condition: true
initial amount: NaN
is encoded by: hsa:1644
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: Q53Y41

http://identifiers.org/biomodels.db/MODEL1310110048#_79d8666d_419d_4955_9297_8e90b44738f7
boundary condition: true
has only substance units: false
is: Q9H0I9
initial concentration: NaN
name: TKTL2
type: Species
is: SBO:0000252
is encoded by: hsa:84076
constant: false
initial amount: NaN

metaR r2126
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110048#
fast: false

metaR PI45P3K
is: SBO:0000176
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
reversible: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110048#
type: Reaction
fast: false

metaR UGALNACtg
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000269
is: SBO:0000185
reversible: true
reactant: MODEL1310110048#
name: UDP-GalNAc Golgi transport via CMP antiport
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110048#

metaR r1606
is: SBO:0000185
kinetic law: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3c34c711_c1d0_4766_91a8_c094f4cf7eec
has only substance units: false
name: OGDHL
initial amount: NaN
initial concentration: NaN
is: Q9ULD0
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55753
type: Species

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/2.3.1.61
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: false
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/1.8.1.4

metaM dttp c
initial amount: NaN
is: CHEBI:37568
has only substance units: false
constant: false
boundary condition: false
is: C00459
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
type: Species
is: SBO:0000247
name: dTTP

metaR ASNNm
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.1
product: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
name: L-asparaginase (mitochondrial)
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm

metaM dolglcp L c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
has only substance units: false
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
boundary condition: false
is: CHEBI:15812
type: Species
is: SBO:0000247

metaM dcmp n
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01202
initial concentration: 1.0
is: CHEBI:57566
name: dCMP(2-)
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
constant: false
has only substance units: false

metaM gar c
is: HMDB02022
is: CHEBI:58457
initial amount: NaN
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
constant: false
type: Species
name: N1-(5-Phospho-D-ribosyl)glycinamide
boundary condition: false
has only substance units: false
is: C03838
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_1c66f174_2f26_4cf1_a479_cf73553b49b8
is: Q9HCC0
is encoded by: hsa:64087
name: MCCC2
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM mlthf m
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01533
type: Species
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
boundary condition: false
is: SBO:0000247
is: C00143

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR RE2649C
fast: false
is described by: ECO:0000000
name: RE2649
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110048#_104fac05_adad_4755_8972_349796eca344
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: O95139
name: NDUFB6
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4712

metaM 2decdicoa m
constant: false
name: 2,7-decadienoylcoa
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966

metaR r1605
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110048#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM lnlncg e
type: Species
boundary condition: false
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: SBO:0000247
is: HMDB03073
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: gamma-linolenate

metaR r2127
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_6a89be7b_96f6_48b1_b487_a9b132b3b1b8
initial amount: NaN
constant: false
is encoded by: hsa:54872
is: SBO:0000252
is: Q8NCI4
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PIGG
type: Species

metaR RE1897C
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true
name: RE1897
is: SBO:0000176
fast: false
reactant: MODEL1310110048#

metaR PROt4 2 r
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
name: Proline transport (sodium symport) (2:1)
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
is described by: ECO:0000006
modifier: MODEL1310110048#
reversible: true
is: SBO:0000185

metaM HC02214 e
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:28852
name: prostaglandin-f1alpha
type: Species
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
constant: false
initial concentration: 1.0

metaM HC01376 m
is: CHEBI:28692
initial amount: NaN
has only substance units: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_99f13429_911e_4e9e_8488_c774f68dc8c9
name: PYCR1
type: Species
is: A6NFM2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5831
has only substance units: false
constant: false

metaM 2dodtricoa m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: C05280
type: Species
is: HMDB03952
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: 2,6,9-dodecatrienoylcoa

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM 3sala c
name: 3-Sulfino-L-alanine
is: SBO:0000247
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: CHEBI:61085
initial amount: NaN
is: C00606
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaR GLNCYSNaEx
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
product: MODEL1310110048#
type: Reaction
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
reversible: false

metaR r0829
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.1.1.37
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110048#

metaM but c
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00039
is: CHEBI:17968
type: Species
boundary condition: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate

metaR r0193
fast: false
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is: SBO:0000176
product: MODEL1310110048#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
reversible: true

metaR KSIt
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
name: keratan sulfate I transport, golgi to extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR RE1810M
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reactant: MODEL1310110048#
fast: false
name: RE1810
kinetic law: MODEL1310110048#
is: SBO:0000176

metaM aacoa c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01484
type: Species
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false
is: SBO:0000247
is: C00332
constant: false
name: Acetoacetyl-CoA

metaR G14T4g
reversible: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110048#
fast: false
type: Reaction
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
kinetic law: MODEL1310110048#

metaR RE3001M
fast: false
name: RE3001
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.34
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_1ccb39d5_6014_4043_a734_c86f4fb4a4bf
is encoded by: hsa:229
type: Species
initial concentration: NaN
is: SBO:0000252
is: P05062
constant: false
initial amount: NaN
name: ALDOB
boundary condition: true
has only substance units: false

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaM 5eipencoa m
is: HMDB02288
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
name: 5,8,11,14,17-eicosapentenoylcoa

metaM pi n
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: hydrogenphosphate
initial amount: NaN
is: HMDB00973
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_2e95b0ca_67c6_4cf7_a628_62e28e3ea3b5
constant: false
initial amount: NaN
is encoded by: hsa:79966
has only substance units: false
initial concentration: NaN
name: SCD5
boundary condition: true
is: SBO:0000252
type: Species
is: Q86SK9

metaR S6T8g
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110048#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110048#

metaM L2aadp6sa c
name: L-allysine
is: HMDB01263
initial concentration: 1.0
is: CHEBI:17917
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076

metaR NADtpu
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: NAD transporter, peroxisome
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ

http://identifiers.org/biomodels.db/MODEL1310110048#_728e6556_42d5_4c11_9c6d_d1258528207e
has only substance units: false
name: ALPP
is: P05187
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:250
initial amount: NaN

metaR PUNP7
is: SBO:0000176
reactant: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
name: purine-nucleoside phosphorylase (Xanthosine)
fast: false
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_d53bf96d_ee0d_4492_b926_639ecf0ff5f6
is: Q9BZX2
type: Species
has only substance units: false
is encoded by: hsa:7371
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: UCK2

metaM ksii core4 pre9 g
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 9
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
is: CHEBI:28067

metaR FRDPtc
is: SBO:0000185
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
reversible: true
type: Reaction
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110048#
is described by: ECO:0000000

metaM nadph c
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00221
constant: false
is: C00005
is: CHEBI:57783
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false

metaM HC02175 e
is: SBO:0000247
is: CHEBI:27689
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
initial concentration: 1.0
name: caprate
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

metaR r2016
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
fast: false

metaR GGH 6DHFe
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is: SBO:0000176
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaM accoa m
is: C00024
type: Species
has only substance units: false
is: HMDB01206
is: CHEBI:57288
name: Acetyl-CoA
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_f880d931_3617_430f_9e5a_a3f5ce6c5574
boundary condition: true
initial amount: NaN
is: P23677
initial concentration: NaN
constant: false
name: ITPKA
is encoded by: hsa:3706
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_b807d203_e839_457b_8d36_92f61bf416b5
type: Species
is encoded by: hsa:1545
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: CYP1B1
is: Q16678
constant: false
boundary condition: true

metaM dolglcp L r
initial concentration: 1.0
is: CHEBI:15812
type: Species
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
boundary condition: false
constant: false
has only substance units: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: SBO:0000247

metaM 5fthf m
constant: false
is: HMDB01562
has only substance units: false
initial concentration: 1.0
is: CHEBI:57457
boundary condition: false
initial amount: NaN
name: 5-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_b5ba0f70_5e7c_45e4_9b6e_fc53f4be171d
initial amount: NaN
is: G0W2N5
name: SLC14A1
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:6563
has only substance units: false
boundary condition: true

metaM prostge2 e
name: prostaglandin E2(1-)
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01220
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
is: SBO:0000247
is: CHEBI:606564
has only substance units: false
type: Species

metaR NDPK6n
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110048#
reversible: true
fast: false
modifier: MODEL1310110048#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000304

metaR OCCOAtx
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
fast: false
name: fatty acid intracellular transport
reversible: true
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM h2o2 c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB03125
is: C00027
name: Hydrogen peroxide
boundary condition: false
is: CHEBI:16240

metaR FATP9t
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110048#
is described by: ECO:0000269
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
name: fatty acid electroneutral transport
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110048#_e13cce61_f8f5_4ac1_91e6_9da69b187ba0
is encoded by: hsa:51102
constant: false
is: Q9BV79
name: MECR
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaR LNELDCCPT1
modifier: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
reversible: false

metaR RE3301C
name: RE3301
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reactant: MODEL1310110048#

metaM pram c
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: C03090
initial amount: NaN
initial concentration: 1.0
is: HMDB01128
constant: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: CHEBI:58681
name: 5-Phospho-beta-D-ribosylamine

metaM pi m
is: CHEBI:43474
initial concentration: 1.0
name: hydrogenphosphate
initial amount: NaN
is: HMDB00973
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_42fb5adc_e1b3_4f08_aaae_a8f76a16d581
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q8NCG5
initial concentration: NaN
is encoded by: hsa:10164
initial amount: NaN
type: Species
constant: false
name: CHST4

metaR MI145PK
type: Reaction
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
name: inositol-1,4,5-trisphosphate 3-kinase
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.127

http://identifiers.org/biomodels.db/MODEL1310110048#_98e8a535_18f3_458c_82c5_ec7b80096820
is: P25874
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: UCP1
boundary condition: true
is encoded by: hsa:7350

metaR PUNP6
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110048#
name: purine-nucleoside phosphorylase (Deoxyinosine)
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
reactant: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110048#_3463ceea_e96f_437f_906f_ed5211dbf7d4
has only substance units: false
is encoded by: hsa:3033
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: HADH
is: Q16836

metaM accoa n
constant: false
has only substance units: false
name: acetyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB01206
type: Species
boundary condition: false
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_f8c8730b_27cb_4f0a_b1be_c6707983d2b2
is encoded by: hsa:23057
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: NMNAT2
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_29cd62a5_d702_4794_9805_fb9e779beeba
is: SBO:0000252
type: Species
is: Q9NSW9
is encoded by: hsa:6553
has only substance units: false
boundary condition: true
name: SLC9A5
initial concentration: NaN
initial amount: NaN
constant: false

metaM gtp m
type: Species
initial amount: NaN
is: CHEBI:37565
constant: false
name: GTP
is: C00044
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273

metaM acgam l
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17411
is: SBO:0000247
type: Species
name: N-acetyl-D-glucosamine

metaR IMPC
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
fast: false
product: MODEL1310110048#
reversible: true
name: IMP cyclohydrolase
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_aa27aa05_d260_4c83_bd97_6cb5b919955d
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: ALDH1B1
boundary condition: true
is: P30837
initial amount: NaN
is encoded by: hsa:219
type: Species

metaR HAS1
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.212
reactant: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
type: Reaction
reversible: false
name: hyaluronan synthase
fast: false

metaM but e
initial concentration: 1.0
boundary condition: false
name: butyrate
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17968
is: HMDB00039

metaR PIACGT
name: phosphatidylinositol N-acetylglucosaminyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.83
product: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.198
kinetic law: MODEL1310110048#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…

http://identifiers.org/biomodels.db/MODEL1310110048#_07adeb8a_0209_4879_98d2_e7d8b5bbd696
constant: false
name: FOLR1
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2348
is: P15328
type: Species
initial concentration: NaN
initial amount: NaN

metaM HC02214 c
initial amount: NaN
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
constant: false
is: CHEBI:28852
boundary condition: false
is: SBO:0000247
has only substance units: false
name: prostaglandin-f1alpha

metaM 4hexdtricoa m
initial amount: NaN
is: HMDB02288
is: SBO:0000247
name: 4,7,10-hexadecatrienoylcoa
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
constant: false

metaR r2018
is described by: ECO:0000000
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
fast: false

metaR r1609
reactant: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PUNP5
is: SBO:0000176
reactant: MODEL1310110048#
name: purine-nucleoside phosphorylase (Inosine)
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#

metaR CYTK6n
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,CTP),nuclear
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110048#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269

metaM xolest2 hs e
is: CHEBI:17002
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: cholesterol ester
boundary condition: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_40326b49_f1d1_43f3_9ab0_ea3a37be1efa
boundary condition: true
name: SLC7A8:SLC3A2
is: SBO:0000297
has only substance units: false
type: Species
has part: Q9UHI5
initial amount: NaN
constant: false
is encoded by: hsa:23428
initial concentration: NaN

metaM h2o2 e
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
is: CHEBI:16240
boundary condition: false
initial amount: NaN
constant: false
name: hydrogen peroxide

metaR AGTim
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.44
type: Reaction
fast: false
reactant: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
is described by: ECO:0000269
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
product: MODEL1310110048#

metaR URIK1
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: false
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110048#
name: uridine kinase (ATP:Uridine)
modifier: MODEL1310110048#
is: SBO:0000176
fast: false

metaR DOLPMT4 Uer
kinetic law: MODEL1310110048#
is: SBO:0000185
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
product: MODEL1310110048#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

metaR LTD4DP
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
kinetic law: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: Leukotriene D4 dipeptidase
product: MODEL1310110048#
reversible: true
type: Reaction

metaM gtp n
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:37565
is: SBO:0000247
name: GTP(4-)
boundary condition: false

metaM ppcoa c
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
boundary condition: false
initial concentration: 1.0
is: HMDB01275
name: Propanoyl-CoA
is: CHEBI:57392
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_9aeb4a61_7298_4fc8_a879_b884bd588387
type: Species
boundary condition: true
is encoded by: hsa:33
initial amount: NaN
is: SBO:0000252
is: P28330
name: ACADL
initial concentration: NaN
has only substance units: false
constant: false

metaR GLYCTO1p
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.3.15
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
name: Glycolate oxidase, peroxisome
is described by: ECO:0000269
fast: false
modifier: MODEL1310110048#
reversible: false

metaR HAS2
reversible: false
modifier: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.212
type: Reaction
is described by: ECO:0000269
product: MODEL1310110048#
name: hyaluronan synthase
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110048#

metaR MALTe
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
kinetic law: MODEL1310110048#
name: alpha-glucosidase, extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.20
type: Reaction
product: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_e093a88d_d410_425b_85f1_33dd9f6f1623
is: Q53YB7
initial amount: NaN
initial concentration: NaN
constant: false
name: COX5B
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1329
type: Species

metaM sph1p e
type: Species
is: HMDB01383
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
constant: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR HOXG
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.14.99.3
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
fast: false
kinetic law: MODEL1310110048#
name: Heme oxygenase 1
reversible: false
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
is described by: ECO:0000134

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_d26c2a1e_449a_4742_86d4_208a8da3b9b7
constant: false
has only substance units: false
is encoded by: hsa:AA532636
name: _AA532636_1_m
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR r2011
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM cys L e
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
name: L-cysteine
initial concentration: 1.0
is: HMDB00574
is: SBO:0000247
type: Species
is: CHEBI:17561
boundary condition: false

metaR 2OXOADPTm
modifier: MODEL1310110048#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
reactant: MODEL1310110048#
is described by: ECO:0000269
fast: false
type: Reaction
name: 2-oxoadipate shuttle (cytosol/mitochondria)
kinetic law: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_4a7f1c0c_a7cd_4a6e_8daa_45a811a7b869
is: P00338
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: LDHA
is encoded by: hsa:3939
type: Species
initial concentration: NaN
is: SBO:0000252

metaR PUNP4
fast: false
is: SBO:0000176
modifier: MODEL1310110048#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyguanosine)
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction

metaM pacald c
type: Species
is: HMDB06236
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: phenylacetaldehyde
initial concentration: 1.0
is: CHEBI:16424

metaM HC01610 e
constant: false
name: CoproporphyrinogenI
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:28607

metaR r0616
is: SBO:0000176
product: MODEL1310110048#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110048#
reversible: true
fast: false
type: Reaction

metaM dttp m
is: C00459
name: dTTP
boundary condition: false
is: SBO:0000247
is: HMDB01342
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_5aab48d0_03ba_4aa1_a2e7_e7746b3bcc0c
boundary condition: true
constant: false
type: Species
name: CTSA
has only substance units: false
is: P10619
is encoded by: hsa:5476
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_3e036833_b596_463e_b703_600dc3a5f620
initial amount: NaN
name: SLC25A21
is: G3V4L5
is: SBO:0000252
constant: false
is encoded by: hsa:89874
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaR GK1
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.8
product: MODEL1310110048#
reactant: MODEL1310110048#
name: guanylate kinase (GMP:ATP)
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
is: SBO:0000176

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaM pep c
name: Phosphoenolpyruvate
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00263
is: C00074
boundary condition: false
initial concentration: 1.0
is: CHEBI:18021
is: SBO:0000247
type: Species
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074

metaR 2AMADPTm
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
product: MODEL1310110048#
type: Reaction
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
modifier: MODEL1310110048#
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_61698d2a_7486_4210_b251_5e11a2edc806
name: SLC7A8
has only substance units: false
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:23428
is: SBO:0000252
boundary condition: true
is: Q86U05

metaM lpam m
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17460
is: HMDB00962
name: lipoamide

metaM triodthy e
is: HMDB00265
has only substance units: false
constant: false
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:18258

metaM hco3 e
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
is: CHEBI:17544
is: C00288
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Bicarbonate

http://identifiers.org/biomodels.db/MODEL1310110048#_86b05cdf_ee17_481e_8f19_4591b6b08dbd
is encoded by: hsa:80150
is: Q7L266
name: ASRGL1
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_37cd32fa_a96c_4bf5_aab1_323c0464f36a
boundary condition: true
name: AK3
type: Species
is encoded by: hsa:50808
initial concentration: NaN
has only substance units: false
is: E7ET30
initial amount: NaN
is: SBO:0000252
constant: false

metaR r0615
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.168
reactant: MODEL1310110048#
fast: false
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
type: Reaction
reversible: true
kinetic law: MODEL1310110048#
is: SBO:0000176

metaR PUNP3
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110048#
reactant: MODEL1310110048#
name: purine-nucleoside phosphorylase (Guanosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
type: Reaction
modifier: MODEL1310110048#

metaM dmnoncoa m
type: Species
is: HMDB11604
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
is: SBO:0000247
initial concentration: 1.0

metaM dttp n
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
name: dTTP
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01342
constant: false
is: CHEBI:37568

metaM ala L m
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
is: CHEBI:16977
name: L-alanine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ae62ac0e_014d_41ef_878b_4042505ba24f
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: _AI191472_1_c
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI191472
boundary condition: true

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM eandrstrn r
is: SBO:0000247
name: 16alpha-hydroxydehydroepiandrosterone
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00352
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h3,12-16,20-21H,4-10H2,1-2H3/t12-,13+,14-,15-,16+,18-,19-/m0/s1 EHMN_ABBREVIATION: C05139
initial concentration: 1.0
is: CHEBI:27771
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8cf0f3ec_4737_4b9c_92f2_db2094bd68c0
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:43
has only substance units: false
constant: false
name: ACHE

http://identifiers.org/biomodels.db/MODEL1310110048#_14186e5a_ed2c_4c57_8aed_c473d04e23d3
name: HSD17B7
initial concentration: NaN
is encoded by: hsa:51478
has only substance units: false
boundary condition: true
is: P56937
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaM CE4792 m
initial concentration: 1.0
name: 3-oxo-cis-8-tetradecenoyl-CoA
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57923
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792

metaR PUNP2
kinetic law: MODEL1310110048#
is described by: ECO:0000269
modifier: MODEL1310110048#
reversible: true
type: Reaction
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is: SBO:0000176
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110048#_910e472c_b60c_4d08_9fa1_dc42ea2375a8
constant: false
is encoded by: hsa:501
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ALDH7A1
is: E7EPT3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_1bd0e2f2_9d57_400c_948c_4b8654a75ccd
type: Species
constant: false
name: SOD2
is: P04179
initial concentration: NaN
is encoded by: hsa:6648
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_964e3b7e_785b_437b_8144_f56cb3749b9b
is: Q59EH3
is encoded by: hsa:52
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: ACP1
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r0614
type: Reaction
reversible: true
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36

metaM retinal c
name: retinal
boundary condition: false
initial concentration: 1.0
is: HMDB01358
constant: false
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:15035

http://identifiers.org/biomodels.db/MODEL1310110048#_e76ed90b_6b27_47ce_a703_385c85de71a7
is encoded by: hsa:3030
name: HADHA
type: Species
boundary condition: true
is: E9KL44
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR LNELDCCPT2
is: SBO:0000176
fast: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: carnitine transferase
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_38e1263b_ffa6_4f90_aad5_b21f89401f81
is encoded by: hsa:217
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ALDH2
type: Species
has only substance units: false
is: P05091
constant: false
initial concentration: NaN

metaR ADNK1m
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110048#
name: adenosine kinase, mitochondrial
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110048#
type: Reaction

metaR SPMTDe
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: SPMTDe
reactant: MODEL1310110048#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110048#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110048#_2e5f5687_d108_4f38_a879_fac5ebafa6f4
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: PANK1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q8TE04
is encoded by: hsa:53354

metaM fadh2 c
initial concentration: 1.0
has only substance units: false
is: HMDB01197
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
name: FADH2(2-)
is: CHEBI:58307

metaR ME2m
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.40
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
name: malic enzyme (NADP), mitochondrial
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is version of: http://identifiers.org/ec-code/1.1.1.38
is: SBO:0000176

metaR RE3273C
kinetic law: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
is: SBO:0000176
modifier: MODEL1310110048#
is described by: ECO:0000000
name: RE3273
fast: false
product: MODEL1310110048#
reversible: true

metaR RE2079R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000176
product: MODEL1310110048#
name: RE2079
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_95c80143_8139_46c9_947b_a014af45bbdb
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23305
type: Species
boundary condition: true
name: ACSL6
constant: false
has only substance units: false
initial concentration: NaN
is: B2RB13

metaR 10FTHFtm
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: true
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
is: SBO:0000185
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110048#_5f54240e_0573_47e7_9445_71ec046e4597
name: PLCG1
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5335
constant: false
is: Q9UFY1

metaM HC02175 c
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
name: caprate
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8738b680_51f1_49d9_a6c9_d0c78b806648
is encoded by: hsa:221823
boundary condition: true
is: SBO:0000252
constant: false
name: PRPS1L1
is: P21108
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_d5ace2fb_b4d1_48e2_a8aa_2888277cf8dc
type: Species
has only substance units: false
is encoded by: hsa:65010
initial concentration: NaN
is: Q9Y3Y1
name: SLC26A6
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR PUNP1
type: Reaction
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
name: purine-nucleoside phosphorylase (Adenosine)

metaM ins c
type: Species
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00294
name: Inosine
constant: false
is: HMDB00195
is: CHEBI:17596
initial concentration: 1.0

metaM prostge2 c
has only substance units: false
is: SBO:0000247
name: prostaglandin E2(1-)
is: CHEBI:606564
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01220
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

http://identifiers.org/biomodels.db/MODEL1310110048#_bb076898_92b8_4e43_827e_bc33ffb21497
name: MTMR2
type: Species
is: SBO:0000252
is: A6NN98
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8898

metaM hyptaur c
initial amount: NaN
name: Hypotaurine
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00965
initial concentration: 1.0
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: CHEBI:16668

metaR r0224
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000000
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR G12MT2 U
is: SBO:0000176
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
fast: false
type: Reaction

metaM ksi pre7 g
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 7
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: CHEBI:58053
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: C00130
is: HMDB00175

metaM cgly c
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:4047
is: HMDB00078
boundary condition: false
name: L-cysteinylglycine
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaR ACGAM6PSi
fast: false
is: SBO:0000176
name: N-acetylglucosamine-6-phosphate synthase
modifier: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.4
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_e6bd367a_5b50_4590_b721_2bf5b7321da0
is encoded by: hsa:622
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: BDH1
has only substance units: false

metaR GLNALANaEx
kinetic law: MODEL1310110048#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
modifier: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b89a598f_9544_481e_b8b9_775347ed4f1c
is encoded by: hsa:5333
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P51178
has only substance units: false
name: PLCD1
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_07a7398d_0b15_49a5_9403_a876f40d17ca
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: P36969
type: Species
name: GPX4
is: SBO:0000252
is encoded by: hsa:2879

http://identifiers.org/biomodels.db/MODEL1310110048#_a70ebbba_0184_419e_8d61_5c2fd95535a7
name: NDUFA4L2
is: Q9NRX3
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:56901
initial amount: NaN
initial concentration: NaN

metaR GACPAILter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
reactant: MODEL1310110048#
is: SBO:0000185
name: glucosaminyl-acylphosphatidylinositol ER flippase
type: Reaction
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_148d3c15_20bd_49e7_8c4c_d815376b6698
boundary condition: true
has only substance units: false
name: ENTPD4
is: Q9Y227
is encoded by: hsa:9583
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_87fbf3e2_1eda_4369_85db_1da1ced633f4
boundary condition: true
has only substance units: false
type: Species
name: SLC27A1
is: SBO:0000252
constant: false
is: Q6PCB7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:376497

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM pi e
constant: false
has only substance units: false
is: C00009
initial concentration: 1.0
type: Species
name: hydrogenphosphate
is: CHEBI:43474
is: HMDB00973
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaM pail5p hs c
boundary condition: false
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_7f7c5d36_c4e6_4293_bb5d_997845437f11
constant: false
boundary condition: true
is encoded by: hsa:64077
is: Q9H008
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: LHPP
initial amount: NaN

metaM nmn c
boundary condition: false
is: CHEBI:14649
name: NMN
is: SBO:0000247
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
initial concentration: 1.0
is: C00455
type: Species
has only substance units: false
is: HMDB00229
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_c8bcb3ff_8a3e_41b4_95f4_86d81b634e03
has only substance units: false
is: P09917
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:240
name: ALOX5
initial amount: NaN

metaM gtp c
constant: false
is: C00044
initial amount: NaN
is: HMDB01273
has only substance units: false
initial concentration: 1.0
is: CHEBI:37565
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
is: SBO:0000247
name: GTP

metaM udpgal c
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
name: UDP-D-galactose(2-)
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_c4b50ff5_8334_454f_b6cb_60e15664cc6a
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _AA576959_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:AA576959

metaM ptth c
is: CHEBI:16753
is: SBO:0000247
name: pantetheine
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB03426
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_314321a5_ff04_431b_9487_73e75d431368
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: F6KD01
constant: false
initial amount: NaN
boundary condition: true
name: PTEN
type: Species
is encoded by: hsa:5728

metaR FPGS4m
reversible: false
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
is described by: ECO:0000000
name: folylpolyglutamate synthetase (DHF), mitochondrial
fast: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.3.2.17
modifier: MODEL1310110048#
is: SBO:0000176

metaR O2tp
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
fast: false
name: O2 transport, peroxisomal
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_6de73e09_5769_4f06_9e17_4280dec4936a
constant: false
name: _AV717590_1_c
has only substance units: false
is encoded by: hsa:AV717590
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_1ce05c89_9b35_47a6_96b4_25e9191e6780
is encoded by: hsa:AI285872
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _AI285872_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_3daf3ba7_666e_451f_8711_a65c240dc64d
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: GLRX2
initial amount: NaN
is encoded by: hsa:51022
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_fbaecae4_0ca0_4db5_8c24_caa2dd0e09f4
boundary condition: true
type: Species
is encoded by: hsa:1962
initial amount: NaN
name: EHHADH
is: Q9NY65
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_bb5eefe3_f2f2_40d5_acaf_b5d7022ce11f
initial concentration: NaN
constant: false
is: Q10469
initial amount: NaN
is encoded by: hsa:4247
boundary condition: true
is: SBO:0000252
name: MGAT2
has only substance units: false
type: Species

metaM galgluside hs g
is: C00015
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
has only substance units: false
is: CHEBI:58223
name: galactosyl glucosyl ceramide
is: SBO:0000247
constant: false
type: Species
is: HMDB00295
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_08457a9d_30a2_4a9f_9f53_3c042586b3e3
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: _286297_1_c
is encoded by: hsa:286297
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_b4daa5fe_73ff_49d9_be85_b53dcc294a0d
initial concentration: NaN
constant: false
name: B4GALT2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:8704

metaM leuktrA4 e
is: CHEBI:57463
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01337
type: Species
name: leukotriene A4(1-)
constant: false
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaR RE1521M
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110048#
name: RE1521
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110048#
fast: false
type: Reaction
modifier: MODEL1310110048#
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR SMS
modifier: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.27
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110048#
name: Sphingomyelin synthase (homo sapiens)

http://identifiers.org/biomodels.db/MODEL1310110048#_487914c8_9f29_454d_94a4_e0d13ec5c94a
is: Q15738
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:50814
name: NSDHL
constant: false
is: SBO:0000252

metaR G14T21g
product: MODEL1310110048#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

metaM itaccoa m
initial amount: NaN
is: CHEBI:57381
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: HMDB03377
name: itaconyl-CoA(5-)
is: SBO:0000247
boundary condition: false
type: Species

metaR TDCHOLAte
reversible: true
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_403ad2c6_9a4e_447f_9d1a_b1a9163b2f9f
constant: false
type: Species
is: Q9P019
is: SBO:0000252
is encoded by: hsa:29085
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PHPT1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_70f17fcb_aa6a_4027_9d23_fa61ccf9e56d
is: P53602
has only substance units: false
is encoded by: hsa:4597
name: MVD
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM mi1345p c
type: Species
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57895
is: HMDB01059
constant: false
initial amount: NaN
initial concentration: 1.0

metaR O2tm
reactant: MODEL1310110048#
is: SBO:0000185
name: O2 transport (diffusion)
product: MODEL1310110048#
fast: false
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is described by: ECO:0000000
reversible: true

metaM cgly e
name: L-cysteinylglycine
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00078
is: CHEBI:4047
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_9c431cb4_8188_4556_ad30_05b1c17c0fa1
is: P48448
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:222
is: SBO:0000252
boundary condition: true
name: ALDH3B2
initial amount: NaN

metaR DAG HSter
name: diacylglycerol ER export
product: MODEL1310110048#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110048#
type: Reaction
fast: false

metaM lnlncg r
is: CHEBI:32391
constant: false
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial amount: NaN
has only substance units: false
is: HMDB03073
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_1cb78ac0_ebd1_49d2_9f7a_157b140d755a
has only substance units: false
is: O15305
type: Species
name: PMM2
initial amount: NaN
boundary condition: true
is encoded by: hsa:5373
initial concentration: NaN
constant: false
is: SBO:0000252

metaM pi g
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
is: HMDB00973
has only substance units: false
is: SBO:0000247
name: hydrogenphosphate

metaM acgam c
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
type: Species
initial amount: NaN
name: N-acetyl-D-glucosamine
is: CHEBI:17411
initial concentration: 1.0
has only substance units: false

metaR P4507A1r
fast: false
modifier: MODEL1310110048#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.14.13.17
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR RE2759X
fast: false
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
reversible: true
name: RE2759
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/5.1.99.4
is described by: ECO:0000000
is: SBO:0000176

metaM triodthy c
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00265
constant: false
is: CHEBI:18258

metaR PYK
name: pyruvate kinase
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_67d2d410_67ef_417a_bb14_494f2ec4f3e6
initial amount: NaN
constant: false
is encoded by: hsa:1718
name: DHCR24
initial concentration: NaN
is: Q15392
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaM sarcs m
is: C00213
is: HMDB00271
type: Species
name: Sarcosine
constant: false
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: CHEBI:15611
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_dd83573d_012b_4fec_a182_c0062e7819a7
type: Species
initial amount: NaN
is: Q16881
constant: false
boundary condition: true
is: SBO:0000252
name: TXNRD1
initial concentration: NaN
is encoded by: hsa:7296
has only substance units: false

metaR r1116
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
type: Reaction
reversible: true

metaM ocdcea c
boundary condition: false
is: HMDB00207
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
name: octadecenoate (n-C18:1)
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_6b1b4894_21d6_4b96_af86_2522d4b33d2c
type: Species
constant: false
name: ALG8
has only substance units: false
is encoded by: hsa:79053
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9BVK2
initial amount: NaN

metaR PItg
is: SBO:0000185
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
reversible: false
name: phosphate transport, Golgi apparatus
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110048#

metaM m4mpdol U r
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
boundary condition: false
initial amount: NaN

metaM retinal cis 9 c
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
type: Species
initial amount: NaN
name: all-trans-retinal

metaM doldp U r
name: Dolichol diphosphate, human uterine homolog
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:15750

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM ksi pre30 g
name: keratan sulfate I biosynthesis, precursor 30
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: C00130
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:58053
boundary condition: false
initial amount: NaN

metaR FAOXC204C184m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR TYRt
product: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
fast: false
name: L-tyrosine transport
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
is: SBO:0000185

metaR RE0344C
name: RE0344
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR XYLUR
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
name: xylulose reductase
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.10
reversible: true
product: MODEL1310110048#
fast: false
is described by: ECO:0000269

metaR CYTDK1
type: Reaction
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
name: ATPcytidine 5-phosphotransferase
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110048#
is described by: ECO:0000254
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_cee85ea2_3654_447e_8b7c_78b1f9748992
is: P21589
name: NT5E
initial concentration: NaN
is encoded by: hsa:4907
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaR RE1796R
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796
is: SBO:0000176
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_d30357f0_b287_4080_9f5c_5859f6ddf719
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:85365
is: Q9H553
type: Species
initial amount: NaN
constant: false
name: ALG2

http://identifiers.org/biomodels.db/MODEL1310110048#_ae0acdf5_628a_429d_993b_a423a82fa9c4
name: PIGQ
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9091
boundary condition: true
is: B2RAU6
type: Species
constant: false

metaR TYRCBOX
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000134
reactant: MODEL1310110048#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
name: L-Tyrosine carboxy-lyase
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
fast: false
modifier: MODEL1310110048#

metaR GMPR
name: GMP reductase
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000176
reversible: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.7.1.7

http://identifiers.org/biomodels.db/MODEL1310110048#_5a385328_32df_47bc_a546_eb049b3705e8
boundary condition: true
has only substance units: false
type: Species
constant: false
name: ADSL
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:158

metaM CE2434 m
boundary condition: false
is: SBO:0000247
is: CHEBI:57795
initial concentration: 1.0
type: Species
initial amount: NaN
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
has only substance units: false
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434

http://identifiers.org/biomodels.db/MODEL1310110048#_c438ec11_4962_4af5_be1b_fd9dad1cba51
type: Species
is encoded by: hsa:2936
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P00390
name: GSR
is: SBO:0000252
boundary condition: true

metaM nadp c
constant: false
has only substance units: false
boundary condition: false
is: HMDB00217
is: CHEBI:58349
is: SBO:0000247
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
is: C00006
initial concentration: 1.0

metaM 3decdicoa m
initial amount: NaN
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: 3,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaR r0940
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
name: Free diffusion
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR DCATDr
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the E.R. by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_0d9c5e48_53d7_4728_94d2_8fba457f9a8a
type: Species
boundary condition: true
initial amount: NaN
is: O43272
is encoded by: hsa:5625
has only substance units: false
initial concentration: NaN
name: PRODH
is: SBO:0000252
constant: false

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM thf c
constant: false
is: SBO:0000247
is: HMDB01846
is: CHEBI:57453
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
name: 5,6,7,8-Tetrahydrofolate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_57420bff_193a_43c4_b063_43c6c228f646
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:284129
type: Species
boundary condition: true
name: SLC26A11
is: Q86WA9
is: SBO:0000252
initial concentration: NaN

metaM udpgal g
is: CHEBI:58439
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
initial amount: NaN
is: HMDB00302
type: Species
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_f93ac2f2_2c17_46f0_8598_987d1728c1a7
initial concentration: NaN
has only substance units: false
name: SLC5A2
boundary condition: true
constant: false
is encoded by: hsa:6524
is: P31639
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_a3da6fea_24e1_4108_a604_5e742db06399
name: SLC5A5
is: Q92911
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:6528

http://identifiers.org/biomodels.db/MODEL1310110048#_bcb20272_e85d_4460_9614_e7abc1b7df32
type: Species
is encoded by: hsa:7360
name: UGP2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q16851
constant: false
has only substance units: false

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
name: inositol-1,4,5-trisphosphate 5-phosphatase
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD

metaM hco3 m
is: HMDB00595
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
type: Species
is: CHEBI:17544
name: Bicarbonate
boundary condition: false
is: C00288
is: SBO:0000247

metaM guln c
is: HMDB03290
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
type: Species
is: CHEBI:13115
has only substance units: false
initial concentration: 1.0
constant: false
name: L-gulonate
boundary condition: false

metaR CYOOm3
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
name: cytochrome c oxidase, mitochondrial Complex IV
modifier: MODEL1310110048#
fast: false
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134

metaM glcur r
is: HMDB00127
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: CHEBI:15748
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM aacoa x
boundary condition: false
is: SBO:0000247
is: CHEBI:57286
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01484
initial concentration: 1.0
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
constant: false
name: acetoacetyl-CoA(4-)

metaM xol7a r
initial amount: NaN
initial concentration: 1.0
constant: false
name: 20-hydroxycholesterol
is: SBO:0000247
has only substance units: false
is: HMDB01496
is: CHEBI:1296
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
type: Species
boundary condition: false

metaR G14T17g
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110048#
reactant: MODEL1310110048#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110048#_33852ae9_2110_4c21_a215_4a47de2d58c8
is: E9KL48
name: GLUD1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2746
has only substance units: false
boundary condition: true
constant: false
type: Species

metaR RPI
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110048#
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/5.3.1.6
reactant: MODEL1310110048#
is: SBO:0000176
name: ribose-5-phosphate isomerase
type: Reaction

metaR r0941
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
name: Free diffusion
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110048#

metaM ksii core2 pre4 g
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 4
is: SBO:0000247
is: C00130
initial amount: NaN
is: HMDB00175
notes: FORMULA: C53H86N4O38X CHARGE: -1
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110048#_9823247f_8956_489a_b120_781a1bf4273b
type: Species
initial amount: NaN
initial concentration: NaN
name: SDHA
is: P31040
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:6389

http://identifiers.org/biomodels.db/MODEL1310110048#_eb45acbf_a514_43ae_818a_dd91dd922fac
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:1375
has only substance units: false
is: B7Z5T8
type: Species
name: CPT1B
initial amount: NaN
is: SBO:0000252

metaR RE1448N
fast: false
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: RE1448
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:

metaR RPEc
product: MODEL1310110048#
is described by: ECO:0000134
reactant: MODEL1310110048#
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110048#

metaR r2007
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
is: SBO:0000185

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a0e0e69c_0b59_43ac_9d00_9d3e4d6fa0fc
boundary condition: true
is: Q1EHB4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: SLC5A12
is encoded by: hsa:159963
constant: false

metaM m6mpdol U r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37635
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

http://identifiers.org/biomodels.db/MODEL1310110048#_e1781d5f_372c_488a_8355_cb2a8bb5870b
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P17516
name: AKR1C4
is encoded by: hsa:1109

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM nh4 n
initial concentration: 1.0
name: ammonium
is: SBO:0000247
is: HMDB00051
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: CHEBI:28938
constant: false
has only substance units: false
initial amount: NaN

metaM lneldccrn c
is: HMDB06461
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
name: Linoelaidyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
constant: false
boundary condition: false
is: SBO:0000247

metaR NDPK5n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
reversible: true
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR 2HBO
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
modifier: MODEL1310110048#
reversible: true
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 2-Hydroxybutyrate:NAD+ oxidoreductase

metaR FATP8t
name: fatty acid electroneutral transport
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
reversible: true
modifier: MODEL1310110048#
fast: false
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.2.1.7
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110048#_0c55dc33_d2f6_4600_9def_4bb93e0a5a49
is encoded by: hsa:51301
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: GCNT4
is: Q9P109
boundary condition: true
constant: false
initial amount: NaN

metaR AKR1C42
is described by: ECO:0000269
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
reversible: false
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_7e090804_9e1f_48f8_b3a4_932c1c7a91f9
has only substance units: false
is: C9JT23
initial amount: NaN
name: NDUFA11
constant: false
is encoded by: hsa:126328
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM udpgal e
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00302
initial amount: NaN
name: UDP-D-galactose(2-)
constant: false
is: SBO:0000247
is: CHEBI:58439

metaR r0942
reversible: true
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
type: Reaction
fast: false
is: SBO:0000185

metaR RPE
type: Reaction
product: MODEL1310110048#
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/5.1.3.1
name: ribulose 5-phosphate 3-epimerase

metaM pe hs r
boundary condition: false
is: SBO:0000247
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16038

http://identifiers.org/biomodels.db/MODEL1310110048#_612c58b6_f491_46f9_8dd7_17639851cde1
is: SBO:0000252
is: P38117
name: ETFB
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:2109
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM formcoa c
is: CHEBI:57376
initial amount: NaN
boundary condition: false
type: Species
name: formyl-CoA(4-)
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB03419
initial concentration: 1.0
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798

metaM prostgd2 r
is: CHEBI:57406
initial amount: NaN
initial concentration: 1.0
constant: false
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01403
type: Species

metaM pi c
constant: false
is: C00009
boundary condition: false
is: HMDB00973
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2
initial concentration: 1.0
has only substance units: false
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110048#_18558d19_ce04_4ef0_9871_a10176709fa8
initial amount: NaN
is: E9PNG0
is: SBO:0000252
type: Species
name: AMPD2
initial concentration: NaN
is encoded by: hsa:271
boundary condition: true
has only substance units: false
constant: false

metaR CORE4GTg
kinetic law: MODEL1310110048#
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
type: Reaction
product: MODEL1310110048#
fast: false
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176

metaM lnlccrn c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Linoleyl carnitine
is: HMDB06469
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_06f44c37_5d46_4da1_bc20_b3e1dda4c913
is: SBO:0000252
is encoded by: hsa:2745
constant: false
type: Species
is: P35754
boundary condition: true
has only substance units: false
initial amount: NaN
name: GLRX
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_2524310c_7787_44bd_a42d_0beb246d0d24
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:205
constant: false
is: P27144
initial concentration: NaN
name: AK4
has only substance units: false

metaR S6T9g
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110048#

metaR NOt
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
name: NO transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110048#_8b91de08_e9fd_4b23_bd65_8ad432fd9d0c
has only substance units: false
is: Q9NWU1
is encoded by: hsa:54995
initial concentration: NaN
name: OXSM
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_1ef7aab2_141e_4c3a_936d_95dac4e78d5c
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: O15254
has only substance units: false
name: ACOX3
is encoded by: hsa:8310
initial amount: NaN
boundary condition: true

metaM orn m
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:46912
boundary condition: false
is: SBO:0000247
is: HMDB00214
type: Species
name: Ornithine
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR AG13T16g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reactant: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_31e9f52a_84e4_4df3_af46_9f4cc4937fd0
initial amount: NaN
initial concentration: NaN
name: UCK1
is: SBO:0000252
boundary condition: true
constant: false
is: Q5JT09
type: Species
has only substance units: false
is encoded by: hsa:83549

http://identifiers.org/biomodels.db/MODEL1310110048#_97d353b3_488f_41b6_91cf_72dc883fa6f8
initial amount: NaN
is: P82251
constant: false
type: Species
name: SLC7A9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11136
is: SBO:0000252
boundary condition: true

metaM HC00229 e
name: Isomaltose
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:28189
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252

metaM leuktrA4 c
is: SBO:0000247
name: leukotriene A4(1-)
is: HMDB01337
is: CHEBI:57463
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
boundary condition: false
initial concentration: 1.0

metaM C05965 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: CHEBI:57444
name: 12(S)-HPETE(1-)
initial amount: NaN
type: Species
is: HMDB04243
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM glyb c
initial amount: NaN
constant: false
is: HMDB00043
is: SBO:0000247
is: CHEBI:17750
boundary condition: false
name: glycine betaine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial concentration: 1.0
has only substance units: false
type: Species

metaR GLYPROPEPT1tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylproline by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_b2779267_41ea_4c56_8f1f_4fe014f96d42
constant: false
boundary condition: true
name: ALDH7A1
is: E7EPT3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:501
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_3bec93ec_1a75_4e11_9940_d8497114a857
is: SBO:0000297
has only substance units: false
has part: Q8TBF5
initial amount: NaN
type: Species
is encoded by: hsa:93183
is encoded by: hsa:54965
has part: Q9H3S5
name: PIGX:PIGM
initial concentration: NaN
constant: false
boundary condition: true

metaR AG13T3g
type: Reaction
modifier: MODEL1310110048#
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR r2117
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_2066fe1d_f6de_4edc_a0b9_b594703275f2
name: ADH7
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:131
is: P40394
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_b47d347b_020d_4465_8cb3_30f0c830f678
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:645
name: BLVRB
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: P30043

metaR RE1826C
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
name: RE1826
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#

metaR RBTt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribitol transport via passive diffusion
fast: false
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is: SBO:0000185

metaR r0944
kinetic law: MODEL1310110048#
name: Active transport
is: SBO:0000185
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_eb86aad1_cd47_448b_bafe_2d0531904f60
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:AV713053
boundary condition: true
name: _AV713053_1_m
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_12e3b583_5b6f_4cec_87ae_7ced5552e6bd
initial amount: NaN
is: P61457
has only substance units: false
constant: false
name: PCBD1
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5092

http://identifiers.org/biomodels.db/MODEL1310110048#_c8ecf6bf_3c44_46c1_9020_6f1cfc107ae2
is encoded by: hsa:644
boundary condition: true
initial amount: NaN
name: BLVRA
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is: P53004
initial concentration: NaN

metaR FAOXC164GC163m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR LYStiDF
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: L-lysine transport via diffusion (extracellular to cytosol)
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
type: Reaction

metaM itp n
initial concentration: 1.0
is: SBO:0000247
name: ITP(3-)
initial amount: NaN
is: CHEBI:57614
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaM ctdecdcoa m
is: C08277
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00792
name: cis2trans4decadienoylcoa
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_834367e9_e5e2_45c8_8038_744f2a675344
constant: false
is: SBO:0000252
is: P20933
initial concentration: NaN
boundary condition: true
name: AGA
has only substance units: false
type: Species
is encoded by: hsa:175
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_82710969_125b_49fa_8b0f_91bfbb94035c
is: Q9NY28
name: GALNT8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:26290

metaR r1755
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185

metaM fuc L e
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: L-fucose
initial concentration: 1.0
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
has only substance units: false
is: CHEBI:18287
is: HMDB00174
is: SBO:0000247

metaM etoh e
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16236
initial amount: NaN
is: HMDB00108
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
name: ethanol

metaM fmn c
is: CHEBI:58210
is: C00061
name: FMN
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
has only substance units: false
is: HMDB01520

http://identifiers.org/biomodels.db/MODEL1310110048#_0a4b471d_a2a5_41a4_979e_0043325e0b11
boundary condition: true
initial concentration: NaN
is: Q9BWD1
is: SBO:0000252
constant: false
is encoded by: hsa:39
name: ACAT2
initial amount: NaN
type: Species
has only substance units: false

metaR r2116
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110048#_d32f68bd_c205_4df4_babb_41869c85e9fc
is encoded by: hsa:57786
type: Species
is: Q9NYW8
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: RBAK
initial amount: NaN
has only substance units: false

metaR GALSGLT1le
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaR NAt
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110048#
fast: false
name: sodium transport (uniport)
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
kinetic law: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#

metaM sarcs c
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0
name: Sarcosine
constant: false
is: HMDB00271
initial concentration: 1.0
is: CHEBI:3513
initial amount: NaN
has only substance units: false
is: C00213

http://identifiers.org/biomodels.db/MODEL1310110048#_beed8ecd_6adf_4b45_8149_0fff239f842a
is: SBO:0000252
is encoded by: hsa:1629
boundary condition: true
name: DBT
type: Species
is: P11182
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_b676362c_1f8f_4111_92f7_ecc681f25706
name: _728226_1_e
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:728226
boundary condition: true
type: Species
has only substance units: false

metaR ACOAO7p
kinetic law: MODEL1310110048#
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR EX dca LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Decanoate (n-C10:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a8c0f1f5_621c_4a5f_8bbf_9ecb5929efab
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SLCO1A2
initial concentration: NaN
constant: false
is: P46721
is encoded by: hsa:6579
type: Species
has only substance units: false

metaR FRDPtr
type: Reaction
name: lipid, flip-flop intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR PI4PP
fast: false
reactant: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
kinetic law: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#
name: phosphatidylinositol-4-phosphate 4-phosphatase
reversible: false

metaR HEX1
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: hexokinase (D-glucose:ATP)

metaM 2dr1p c
name: 2-Deoxy-D-ribose 1-phosphate
is: CHEBI:58576
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00672
is: HMDB01351
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672

metaM gmp c
is: SBO:0000247
initial amount: NaN
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
is: C00144
boundary condition: false
constant: false
has only substance units: false
is: HMDB01397
name: GMP
type: Species

metaM nh4 m
is: CHEBI:28938
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
initial concentration: 1.0
initial amount: NaN
is: C01342
is: HMDB00051
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_3f465d44_0e4d_4296_9b15_716fb8ffc2f1
has only substance units: false
is: E7EPA7
is encoded by: hsa:7086
is: SBO:0000252
initial amount: NaN
constant: false
name: TKT
type: Species
boundary condition: true
initial concentration: NaN

metaR r1754
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
reversible: false

metaM dmnoncoa x
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: HMDB11604
type: Species
boundary condition: false
name: 4,8 dimethylnonanoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_605c8386_b91d_4d8b_9e30_14a518169cd8
name: NAGA
is: P17050
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:4668
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_009409cd_baa6_4804_aa17_b229d52cdb7e
is: SBO:0000252
name: PLCZ1
is encoded by: hsa:89869
initial concentration: NaN
constant: false
is: Q86YW0
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR TCHOLAtx
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
is: SBO:0000185
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#

metaR ALACYSNaEx
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
fast: false
type: Reaction
product: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR DCYTDn
modifier: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is version of: http://identifiers.org/ec-code/3.5.4.5
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
reversible: false
is described by: ECO:0000254
name: deoxycytidine deaminase, nuclear
product: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ec080aa8_1539_43bb_89b1_35fdac241ed5
is: SBO:0000252
constant: false
has only substance units: false
name: FADS1
boundary condition: true
initial concentration: NaN
is: O60427
type: Species
is encoded by: hsa:3992
initial amount: NaN

metaR r2341
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_1c662433_621b_485b_a7da_ddba3396cd1d
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: HMGCS1
is encoded by: hsa:3157
is: SBO:0000252

metaR DAGK hs
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
modifier: MODEL1310110048#
name: Diacylglycerol phosphate kinase (homo sapiens)
is described by: ECO:0000269

metaR r0946
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

metaR GLYtp
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
name: glycine passive transport to peroxisome
fast: false

metaR PVD3
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000134
name: Previtamin D3 formation
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaR EX 34hpp
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR NAHCO3 HCLt
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
type: Reaction
name: bicarbonate transport (HCl/NaHCO3 exchange)

http://identifiers.org/biomodels.db/MODEL1310110048#_098e75a2_a181_4182_89dc_8df22fa4ac7b
name: PIK3CD
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5293
is: SBO:0000252
boundary condition: true
is: A7E2E0

metaR PItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: phosphate transport, nuclear
product: MODEL1310110048#
fast: false
reversible: true
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110048#

metaR ITCOAL1m
product: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
fast: false
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000304
is: SBO:0000176

metaM thyox L e
is: HMDB00248
name: L-thyroxine
is: SBO:0000247
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial amount: NaN
constant: false
is: CHEBI:18332
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

metaM 13dpg c
is: C00236
name: 3-Phospho-D-glyceroyl phosphate
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: HMDB01270
is: http://identifiers.org/pubchem.compound/3535
is: CHEBI:57604
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_39e83db0_8df3_4197_86f2_260052d851d6
is encoded by: hsa:134526
type: Species
name: ACOT12
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: Q5FWE9

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
modifier: MODEL1310110048#
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
fast: false

metaM prostgd2 e
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
name: prostaglandin D2(1-)
initial amount: NaN
type: Species
is: CHEBI:57406
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01403

metaR r2119
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_d30b3428_1be9_4835_a695_0533fe1b32e4
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P33316
constant: false
name: DUT
is encoded by: hsa:1854

metaR CITRtm
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000269
fast: false
name: citrulline mitochondrial transport via proton antiport

metaM 5tedtricoa m
name: 5,8,11-tetradecatrienoylcoa
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110048#_7ff31aa1_b0a5_419e_a499_331c10a5a479
is encoded by: hsa:549
is: SBO:0000252
initial amount: NaN
type: Species
is: Q13825
has only substance units: false
name: AUH
boundary condition: true
initial concentration: NaN
constant: false

metaM CE2417 m
type: Species
initial concentration: 1.0
is: HMDB11123
is: CHEBI:28387
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
boundary condition: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaM sbcoa x
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_e961208c_5ed3_4368_8669_ab4a24264770
name: AADAT
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:51166
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: Q4W5N8

metaM CE0233 c
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
is: HMDB01993
has only substance units: false
constant: false
name: 5beta-cholestane-3alpha,7alpha,27-triol
initial concentration: 1.0
is: CHEBI:17899
initial amount: NaN
boundary condition: false
type: Species

metaR FACOAL2042
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110048#
reactant: MODEL1310110048#

metaR r2118
type: Reaction
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM dhdascb c
has only substance units: false
is: HMDB01264
name: dehydroascorbide(1-)
constant: false
initial concentration: 1.0
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial amount: NaN
is: SBO:0000247
is: CHEBI:58070
boundary condition: false
type: Species

metaM 2mb2coa m
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial concentration: 1.0
has only substance units: false
is: CHEBI:57337
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4f999ff5_169d_4172_8259_f86ae8fa76e5
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:641371
name: ACOT1
initial amount: NaN
initial concentration: NaN
is: E9KL42
type: Species
boundary condition: true

metaM dmnoncrn m
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
name: 4,8 dimethylnonanoyl carnitine
constant: false
is: SBO:0000247
is: HMDB06202
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

metaM sarcs e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247
type: Species
is: HMDB00271
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: sarcosine
is: CHEBI:15611

metaM ptth m
has only substance units: false
is: HMDB03426
is: SBO:0000247
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
is: CHEBI:16753
name: pantetheine
boundary condition: false
initial amount: NaN
constant: false

metaM cholp g
has only substance units: false
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: C00588
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:295975
name: choline phosphate(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_71598c1c_7232_4682_9a3a_50f7e8f99506
constant: false
is: F8VQS7
is encoded by: hsa:55967
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: NDUFA12

metaM chito2pdol U c
constant: false
is: CHEBI:12427
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR PYNP2r
product: MODEL1310110048#
is described by: ECO:0000269
reactant: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is version of: http://identifiers.org/ec-code/2.4.2.3
kinetic law: MODEL1310110048#
name: pyrimidine-nucleoside phosphorylase (uracil)

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaM spmd e
initial amount: NaN
name: Spermidine
is: HMDB01257
type: Species
is: C00315
is: SBO:0000247
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: CHEBI:57834
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR r0590
is: SBO:0000176
modifier: MODEL1310110048#
type: Reaction
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
product: MODEL1310110048#

metaR MMMm
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/5.4.99.2
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_a76c3758_0f4b_4fb5_9937_fa937222f183
is encoded by: hsa:1491
is: P32929
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CTH
has only substance units: false
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_4512a4f9_0279_4730_bca0_39066fd8b749
initial amount: NaN
is: P02730
type: Species
name: SLC4A1
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:6521
is: SBO:0000252
initial concentration: NaN

metaM clpndcoa x
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial concentration: 1.0
name: clupanodonyl CoA
is: http://identifiers.org/pubchem.compound/47205476
is: HMDB06267
is: C16166
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_6376bd85_6e45_4faf_8011_a031a37c43d7
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P06132
is encoded by: hsa:7389
name: UROD
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_962f0afe_c120_4889_a6d3_90eb749524b2
initial amount: NaN
is encoded by: hsa:3988
type: Species
initial concentration: NaN
constant: false
is: P38571
name: LIPA
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR LSTO1r
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
name: Lathosterol oxidase
is version of: http://identifiers.org/ec-code/1.14.21.6
reversible: false
kinetic law: MODEL1310110048#
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110048#
reactant: MODEL1310110048#

metaM ocdcea e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
initial concentration: 1.0
name: octadecenoate (n-C18:1)
is: C00712
has only substance units: false
constant: false
is: HMDB00207
is: CHEBI:0
type: Species

metaR FAOXC10C8x
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_6c728b6c_3bc6_4139_a680_159335afa623
type: Species
initial concentration: NaN
is: SBO:0000297
constant: false
has part: Q9UPY5
initial amount: NaN
name: SLC7A11:SLC3A2
has only substance units: false
is encoded by: hsa:23657
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_59d3b5f4_4699_4d37_b007_15cb94bcea05
is encoded by: hsa:8884
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9HD19
initial concentration: NaN
name: SLC5A6
initial amount: NaN
type: Species
constant: false

metaR RE1532M
reactant: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1532
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
product: MODEL1310110048#
reversible: true

metaR NADH2 u10m
reactant: MODEL1310110048#
is described by: ECO:0000134
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: false
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
name: NADH dehydrogenase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is: SBO:0000185

metaR KHte
reversible: true
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
name: KHte
kinetic law: MODEL1310110048#
is described by: ECO:0000134
reactant: MODEL1310110048#
fast: false

metaR GBA
is version of: http://identifiers.org/ec-code/3.2.1.45
modifier: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
name: Glucosylceramidase
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110048#

metaM lnlccrn m
boundary condition: false
type: Species
name: Linoleyl carnitine
is: HMDB06469
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1

metaM 2hexdtetcoa m
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB02288
type: Species
initial concentration: 1.0
name: 2,7,10,13-hexadecatetraenoylcoa
has only substance units: false
initial amount: NaN
constant: false

metaR r1051
reactant: MODEL1310110048#
name: Vesicular transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true

metaR IDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: IDP nuclear transport
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000000

metaM lnlncg l
type: Species
is: SBO:0000247
is: HMDB03073
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_8353f160_d60f_4b7b_9583_a0d750ae627f
boundary condition: true
has only substance units: false
is: SBO:0000252
name: TPI1P2
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:286016
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_d33cd27e_7406_421b_8cdb_46e1d90e2de5
initial amount: NaN
is: Q5JRA6
boundary condition: true
is encoded by: hsa:375056
is: SBO:0000252
name: MIA3
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaR PCHOLHSTDe
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: PCHOLHSTDe
type: Reaction

metaR GLCter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
name: glucose transport, endoplasmic reticulum
is: SBO:0000185
type: Reaction

metaM CE5125 x
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
initial amount: NaN
has only substance units: false
is: CHEBI:12947
constant: false
boundary condition: false
name: (2S)-pristanoyl-CoA
type: Species
is: SBO:0000247

metaR CYTK14n
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
product: MODEL1310110048#

metaR GLXO2p
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.3.15
product: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
fast: false
name: glyoxylate oxidase, peroxisomal
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD

metaR ACETONEt2m
reversible: true
name: acetone mitochondrial transport via proton symport
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110048#
is described by: ECO:0000000

metaM 2docohexecoa m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB02288
name: 2,7,10,13,16,19-docosahexenoylcoa
constant: false
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_95883018_eaca_4c3d_bbad_a7148789f141
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:27306
is: O60760
name: HPGDS
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_55ba6cda_f42a_4adc_82f4_d6063cc895b0
boundary condition: true
name: ALAS1
constant: false
initial concentration: NaN
is encoded by: hsa:211
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is: Q5JAM2

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_13b6249a_81be_4bb5_9eba_9f74e97741f5
type: Species
is encoded by: hsa:8140
name: SLC7A5
boundary condition: true
is: Q8IV97
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaM dca r
notes: FORMULA: C10H19O2 CHARGE: -1
name: Decanoate (n-C10:0)
is: SBO:0000247
has only substance units: false
is: C14143
is: HMDB04047
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR TRIODTHYt2
fast: false
reversible: true
type: Reaction
name: T3 transport via facilitated diffusion
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
modifier: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000269

metaM accoa x
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
constant: false
is: CHEBI:57288
is: HMDB01206
initial concentration: 1.0
type: Species
name: Acetyl-CoA
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6205286e_c5e6_4b5b_9ad9_220b879e4602
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P51648
name: ALDH3A2
constant: false
initial amount: NaN
is encoded by: hsa:224

metaR 3MOBt2im
reversible: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
product: MODEL1310110048#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000

metaM thcholstoic c
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
is: SBO:0000247
is: HMDB03873
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_b34387b7_6011_49c7_ae39_939ae3a9afd6
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI934540
constant: false
initial concentration: NaN
type: Species
name: _AI934540_1_c
is: SBO:0000252
boundary condition: true

metaR r1750
is: SBO:0000185
product: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
name: Y+LAT2 Utilized transport

metaR r1600
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000

metaM gmp g
type: Species
name: GMP(3-)
is: CHEBI:58115
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01397
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

http://identifiers.org/biomodels.db/MODEL1310110048#_0f2c0645_c150_4ecd_8bd3_cbd30fd1489a
constant: false
boundary condition: true
is encoded by: hsa:AI291895
type: Species
initial concentration: NaN
name: _AI291895_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_e9efd84b_46f5_4890_81f0_33de635438f2
is: P04843
type: Species
is: SBO:0000252
initial amount: NaN
name: RPN1
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6184

http://identifiers.org/biomodels.db/MODEL1310110048#_fdfab42f_44d2_4972_a8d3_1c483a948796
type: Species
is: Q02218
initial amount: NaN
is: SBO:0000252
name: OGDH
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4967

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM gpi sig r
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37568
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: C00459
is: HMDB01342
notes: FORMULA: Y CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110048#_203d2201_eee3_4c76_bd1b_f619cf0a08df
name: AADAT
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: Q8N5Z0
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51166

metaR DHORTS
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.1.3.2
fast: false
reversible: true
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: dihydroorotase

http://identifiers.org/biomodels.db/MODEL1310110048#_384f6edc_65ee_4c29_881b_cdce3430af32
has only substance units: false
is: Q6IB80
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: NDUFB3
is encoded by: hsa:4709
initial concentration: NaN
constant: false

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
modifier: MODEL1310110048#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110048#
fast: false
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_fc2f42e3_f7ad_4332_af1b_dd0666438d85
boundary condition: true
is: Q9NY59
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SMPD3
constant: false
is encoded by: hsa:55512
type: Species

metaR PNTOt5
name: Pantothenate sodium symporter II
modifier: MODEL1310110048#
product: MODEL1310110048#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8884.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10329687,PMID:10334869,PMID:12646417,PMID:15561972,PMID:9516450 NOTES:_01-25-05 based on Wang et al., JBC, 1999,1 274(21), 14875-14888. IT 03-07-05:replaced IT: now based on Balamurugan et al, 2005, Am J Physiol Renal Physiol, 288, F823-831,2005
reactant: MODEL1310110048#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_d6891f19_2723_4d33_9155_de87bbac8409
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q92781
type: Species
name: RDH5
is encoded by: hsa:5959
is: SBO:0000252

metaM glcur l
type: Species
is: HMDB00127
constant: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
name: D-glucuronate
has only substance units: false
is: CHEBI:15748
initial amount: NaN
boundary condition: false

metaR DOPAt4 2 r
product: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
name: Dopamine reversible transport in via sodium symport (1:2)

http://identifiers.org/biomodels.db/MODEL1310110048#_28a455b0_5cc4_4902_888d_d69ef75325d5
is: Q9Y345
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9152
is: SBO:0000252
name: SLC6A5
boundary condition: true
constant: false
type: Species

metaM etoh c
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16236
name: ethanol
initial amount: NaN
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: HMDB00108
boundary condition: false

metaM btn c
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Biotin
is: C00120
is: CHEBI:3420
is: SBO:0000247
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
constant: false

metaR 3AIB Dtm
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
kinetic law: MODEL1310110048#
name: transport of 3aib_D into mitochondria
reversible: true
is: SBO:0000185
is described by: ECO:0000134
fast: false

metaR GLCNACT U
product: MODEL1310110048#
fast: false
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110048#

metaR GLYtm
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
name: glycine passive transport to mitochondria
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#

metaR SARCStm
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
name: Sarcosine transport (mitochondrial)
product: MODEL1310110048#
is described by: ECO:0000000

metaM aacoa m
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false
constant: false
is: CHEBI:57286
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01484
type: Species
name: acetoacetyl-CoA(4-)
is: SBO:0000247

metaR r1824
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_75fb2ca9_f77d_4b1e_84a5_6d78874227f4
has part: P13073
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q02221
has part: P12074
is encoded by: hsa:1345
initial amount: NaN
has part: P14854
boundary condition: true
is encoded by: hsa:4512
has part: Q7GXY8
is encoded by: hsa:4513
is encoded by: hsa:1347
has part: Q7Z4L0
has part: Q53XN1
type: Species
is encoded by: hsa:1340
is encoded by: hsa:1339
has part: Q6YFQ2
has part: P20674
is encoded by: hsa:1327
has part: P15954
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:1329
is encoded by: hsa:170712
has part: Q53YB7
is encoded by: hsa:9377
is encoded by: hsa:1351
has part: P09669
has part: Q7GXZ8
has part: Q6FGA0
is encoded by: hsa:1337
has only substance units: false
is encoded by: hsa:341947
has part: P00414
is encoded by: hsa:84701
has part: P24310
is encoded by: hsa:1346
has part: Q8TF08
is encoded by: hsa:125965
has part: H0UI06
is encoded by: hsa:9167
has part: P24311
constant: false
is encoded by: hsa:1350
is encoded by: hsa:4514
is encoded by: hsa:1349
has part: Q96KJ9

http://identifiers.org/biomodels.db/MODEL1310110048#_52cdd1cf_0ca2_471d_a1d9_7f341ac2f6a2
initial concentration: NaN
is encoded by: hsa:AI480132
name: _AI480132_1_c
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaR r2344
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110048#_6cc97753_adcd_48a0_9369_1156c957b231
has only substance units: false
constant: false
is encoded by: hsa:H17063
name: _H17063_1_m
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_4f47f00f_3ee2_4921_a4cd_6b6c5d672c8b
initial concentration: NaN
constant: false
name: _U37519_1_m
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:U37519
boundary condition: true

metaR CYTD
name: cytidine deaminase
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.5.4.5
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR r1752
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110048#
reversible: false

metaR ASPTA
name: aspartate transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110048#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_b1d7152c_0348_4b05_a759_cbe5f49e8349
initial concentration: NaN
constant: false
is: P60891
is encoded by: hsa:5631
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: PRPS1

metaR SO4HCOtex
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: sulfate transport via bicarbonate countertransport
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_8b595d1b_33ac_4312_83a1_5242bc9de408
has only substance units: false
initial amount: NaN
name: HMOX2
boundary condition: true
is: P30519
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:3163
is: SBO:0000252

metaM 5mta e
is: C00170
notes: FORMULA: C11H15N5O3S CHARGE: 0
boundary condition: false
is: CHEBI:17509
constant: false
is: HMDB01173
name: 5-Methylthioadenosine
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_a3bad1a0_1052_4332_aee0_8801361a4f7b
is: Q9UBX3
name: SLC25A10
initial amount: NaN
is encoded by: hsa:1468
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b76ced16_be68_4198_91a3_253f5b4b1783
is encoded by: hsa:5331
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PLCB3
is: G5E960
initial amount: NaN

metaR r1695
fast: false
product: MODEL1310110048#
reversible: false
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a5b73efa_9a3f_4fcc_bb4a_acf4a9f2488a
is: SBO:0000252
initial amount: NaN
is: P17174
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2805
name: GOT1
has only substance units: false
constant: false
type: Species

metaR FACOAL180i
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: C180 fatty acid activation
reversible: false
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269

metaM HC01361 e
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
constant: false
initial concentration: 1.0
is: CHEBI:17001
type: Species
boundary condition: false
initial amount: NaN
name: Dihydroneopterin
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_afaf0832_e7de_4217_89f6_b36eb577f87f
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI769281
name: _AI769281_1_e
has only substance units: false

metaR TDCHOLAtx
is described by: ECO:0000000
name: bile acid intracellular transport
is: SBO:0000185
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
fast: false

metaR AMPDA
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
reversible: false
is described by: ECO:0000269
name: Adenosine monophosphate deaminase
is: SBO:0000176
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.5.4.6
product: MODEL1310110048#
type: Reaction
fast: false

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR DHCR72r
product: MODEL1310110048#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is described by: ECO:0000269

metaR SIAT9g
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.9
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is: SBO:0000176

metaR CYTK12
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP)
is described by: ECO:0000269
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176

metaM btcoa m
initial concentration: 1.0
is: HMDB01088
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
constant: false
name: Butanoyl-CoA
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57371
type: Species
is: C00136

http://identifiers.org/biomodels.db/MODEL1310110048#_160a2558_1de1_42bc_adbc_376d1e2ce7c9
is encoded by: hsa:1757
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SARDH
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: A8K596

metaM bilglcur r
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR 34DHPLACOX NADP
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
fast: false
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
reversible: true
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110048#

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR r1614
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110048#
fast: false
is: SBO:0000185
reactant: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000

metaM 1p3h5c c
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
constant: false
initial amount: NaN
is: HMDB01369
type: Species
is: CHEBI:6151
initial concentration: 1.0
name: L-1-Pyrroline-3-hydroxy-5-carboxylate

metaM ksii core2 g
name: keratan sulfate II (core 2-linked)
is: HMDB01644
has only substance units: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17140

metaM prostge1 e
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
boundary condition: false
is: HMDB01442
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57397
type: Species

metaR r0726
type: Reaction
modifier: MODEL1310110048#
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110048#
reactant: MODEL1310110048#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/2.7.1.33

metaR r0688
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:

metaR r1696
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

metaR r0575
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110048#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction

metaR BILGLCURtr
fast: false
name: glucuronidated compound transport
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reversible: true
kinetic law: MODEL1310110048#

metaR C160CPT2
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
name: C160 transport into the mitochondria
product: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false

metaR r2420
reactant: MODEL1310110048#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
reversible: true
fast: false
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#

metaR CYTK13
is: SBO:0000176
type: Reaction
name: cytidylate kinase (dCMP,dATP)
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
product: MODEL1310110048#

metaR PROSTGF2t
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
reversible: true
reactant: MODEL1310110048#
type: Reaction

metaM pmtcrn r
name: L-palmitoylcarnitine
initial concentration: 1.0
constant: false
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_42172ad2_37da_40dc_b052_a05edac7e14f
initial concentration: NaN
name: ALG1
is encoded by: hsa:56052
has only substance units: false
is: Q9BT22
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_2353087c_c7c0_4cfe_9369_8571170dbaec
boundary condition: true
is: P15104
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: GLUL
constant: false
is: SBO:0000252
is encoded by: hsa:2752

metaR FAOXTC122TC101m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaM m4mpdol U c
initial concentration: 1.0
type: Species
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:37633
initial amount: NaN

metaR DESAT18 3
reversible: false
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110048#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110048#
type: Reaction

metaR DESAT20 1
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110048#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_561bf188_9a94_4019_a125_d83e0dae80e3
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:50
boundary condition: true
has only substance units: false
name: ACO2
initial amount: NaN
constant: false
is: Q99798

http://identifiers.org/biomodels.db/MODEL1310110048#_bb79b11b_090f_42d9_9331_30cc8de79f0f
constant: false
name: SLC26A1
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:10861
initial concentration: NaN
has only substance units: false

metaM ksii core2 pre9 g
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
boundary condition: false
type: Species
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0

metaR r1613
reversible: true
is: SBO:0000185
reactant: MODEL1310110048#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM 5adtststerones e
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
boundary condition: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
constant: false
has only substance units: false

metaM n2m2nmasn e
has only substance units: false
is: C04946
boundary condition: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR AKR1D2
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is described by: ECO:0000269
reactant: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.3
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaM ksii core2 e
type: Species
name: keratan sulfate II (core 2-linked)
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17268
constant: false
is: HMDB00211
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4

metaR r1693
product: MODEL1310110048#
fast: false
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_561bff60_9b29_4d16_847f_b7fa7c509ebe
is encoded by: hsa:23657
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9UPY5
boundary condition: true
constant: false
initial concentration: NaN
name: SLC7A11

metaM orn c
boundary condition: false
is: C01602
is: CHEBI:0
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
constant: false
is: HMDB00214
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false

metaR r1492
name: Utilized transport
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000

metaR S6T15g
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
type: Reaction
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.8.2.21
is version of: http://identifiers.org/ec-code/2.8.2.17
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110048#

metaM ach e
is: HMDB00895
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: acetylcholine
is: CHEBI:15355
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_2cb51693_7ff0_4551_999c_5eda06815bc0
has only substance units: false
name: B3GNT4
type: Species
constant: false
boundary condition: true
is: Q9C0J1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:79369

metaM asp L m
initial concentration: 1.0
is: HMDB00191
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:29991
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_c284fae8_95fa_4c18_8b5c_6871f7c8061e
is: Q13613
initial concentration: NaN
has only substance units: false
name: MTMR1
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8776

http://identifiers.org/biomodels.db/MODEL1310110048#_30d82702_bbe4_4190_9f5c_12c617a45d2c
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:NM 013421
boundary condition: true
is: SBO:0000252
constant: false
name: _NM_013421_1_m

metaM 5mta c
name: 5-Methylthioadenosine
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:17509
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: HMDB01173
is: C00170
type: Species
constant: false

metaR CYTK14
product: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110048#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,UTP)
reactant: MODEL1310110048#
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_f1e98fb4_875a_421b_8e10_5b16e611e7eb
is: SBO:0000252
initial concentration: NaN
name: _AI620219_1_m
constant: false
is encoded by: hsa:AI620219
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_8d42d9af_5154_4b9c_9538_c7b15f3b9b97
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: P30838
is encoded by: hsa:218
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALDH3A1

metaM dag hs r
boundary condition: false
type: Species
name: diglyceride
has only substance units: false
initial concentration: 1.0
is: CHEBI:18035
initial amount: NaN
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_0acc65e1_cebf_4ce1_b3d8_dd7fbb26716e
initial concentration: NaN
type: Species
constant: false
is: Q7Z7B1
initial amount: NaN
name: PIGW
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:284098

metaR r2132
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
modifier: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d4214093_480f_4b98_a11d_b92a63961fb0
constant: false
is: P37268
has only substance units: false
is encoded by: hsa:2222
initial amount: NaN
name: FDFT1
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM prostge1 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01442
is: SBO:0000247
name: prostaglandin E1(1-)
constant: false
is: CHEBI:57397
type: Species

metaR r0728
is: SBO:0000176
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM leuktrC4 e
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
initial concentration: 1.0
is: HMDB01198
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: leukotriene C4(2-)
is: CHEBI:57973

metaR r2346
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: true

metaR r1616
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reversible: true
type: Reaction

metaR r1548
is described by: ECO:0000000
product: MODEL1310110048#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
reversible: true
fast: false

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR ADSK
product: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.25
fast: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
name: adenylyl-sulfate kinase

metaM leugly e
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial amount: NaN
name: Leucylglycine
is: http://identifiers.org/pubchem.compound/97364
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_d3eaa391_2c6c_4bfc_8f93_1d0c7a513762
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
has part: Q86U05
is encoded by: hsa:23428
boundary condition: true
is: SBO:0000297
name: SLC7A8:SLC3A2

metaM CE2421 m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB02329
name: (3S)-3-hydroxylinoleoyl-CoA
type: Species
is: SBO:0000247
is: CHEBI:30623
constant: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421

http://identifiers.org/biomodels.db/MODEL1310110048#_d07cc7ed_9704_4f86_adef_adfb6ea792d6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PGK2
type: Species
is encoded by: hsa:5232
is: P07205
constant: false
has only substance units: false
boundary condition: true

metaR r0686
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000176
product: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110048#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000

metaR TMDK1
modifier: MODEL1310110048#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110048#
name: thymidine kinase (ATP:thymidine)
is version of: http://identifiers.org/ec-code/2.7.1.21
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_b9f66710_451a_4bd0_8dd9_574555cf6200
initial amount: NaN
constant: false
initial concentration: NaN
name: _AI469183_1_x
boundary condition: true
is encoded by: hsa:AI469183
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_96ab8599_04ac_4636_ba8d_b8843cd332db
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:54344
constant: false
name: DPM3
is: Q86TM7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_28f2aafb_c858_4775_b773_722684e4dde7
type: Species
name: _T83654_1_e
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:T83654
initial amount: NaN
is: SBO:0000252

metaM duri n
is: HMDB00012
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
name: 2'-deoxyuridine
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_fc856295_96ba_421c_ae29_17461b32e243
name: RHAG
is encoded by: hsa:6005
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q96E98
constant: false

metaR G12MT1 U
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110048#
type: Reaction
reversible: false
kinetic law: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110048#
fast: false

metaM dctp c
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16311
has only substance units: false
is: C00458
name: dCTP
type: Species
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458

metaR G14T11g
product: MODEL1310110048#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
kinetic law: MODEL1310110048#

metaR r2347
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110048#
is: SBO:0000185

metaM 2obut c
is: HMDB00005
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
is: C00109
type: Species
has only substance units: false
is: CHEBI:16763
constant: false
initial amount: NaN
name: 2-Oxobutanoate

metaR r2133
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR r1549
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110048#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110048#
type: Reaction

metaM 5adtststerones c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial amount: NaN
has only substance units: false
boundary condition: false

metaR r0834
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
product: MODEL1310110048#
fast: false
reversible: true

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR r1615
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DCSPTN1CPT2
type: Reaction
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
product: MODEL1310110048#
name: carnitine transferase
modifier: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_89a1cdc6_a8cb_4079_ab38_a802f32249cd
type: Species
is: P78382
boundary condition: true
is: SBO:0000252
name: SLC35A1
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10559

http://identifiers.org/biomodels.db/MODEL1310110048#_58ac002e_d1fa_4f91_a39e_4925c1239c4f
name: GCAT
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:23464
constant: false
is: SBO:0000252
initial concentration: NaN
is: E2QC23

metaR r0570
product: MODEL1310110048#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is version of: http://identifiers.org/ec-code/6.3.3.2
is described by: ECO:0000000
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
fast: false

metaM ach c
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00895
has only substance units: false
is: SBO:0000247
type: Species
name: acetylcholine
is: CHEBI:15355

http://identifiers.org/biomodels.db/MODEL1310110048#_768324fc_61fb_4169_9181_6b0348dbb142
name: NDUFV2
is encoded by: hsa:4729
boundary condition: true
is: P19404
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM leuktrC4 c
is: SBO:0000247
name: leukotriene C4(2-)
is: CHEBI:57973
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
has only substance units: false
type: Species

metaM mal L c
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: HMDB00156
has only substance units: false
name: (S)-malate(2-)
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false
is: CHEBI:15589

metaM octe5coa m
name: 5-octenoylcoa
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

metaR r1546
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110048#
reversible: true
type: Reaction

metaR GAPD
type: Reaction
product: MODEL1310110048#
fast: false
name: glyceraldehyde-3-phosphate dehydrogenase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000176
reversible: true

metaM citr L e
type: Species
boundary condition: false
name: citr_L[e]
constant: false
is: HMDB00904
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
is: CHEBI:16349

http://identifiers.org/biomodels.db/MODEL1310110048#_e6a8afef_620d_4423_9eec_d9f8035ad868
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:23236
initial amount: NaN
initial concentration: NaN
is: Q9NQ66
boundary condition: true
name: PLCB1

metaR ASPDTDe
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000134
fast: false
name: D-aspartate transport, extracellular
type: Reaction

metaM cholp c
constant: false
is: CHEBI:295975
boundary condition: false
name: choline phosphate(1-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: SBO:0000247

metaM acmana c
is: CHEBI:17122
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-mannosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: HMDB01129
constant: false

metaR r1618
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#

metaR 7DHFtm
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: 7-glutamyl-DHF transport,m mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR FAOXC61m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_d18cd730_a230_45b8_8a74_9eb09b7f25a1
has only substance units: false
initial amount: NaN
name: _AI024818_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI024818
type: Species
constant: false

metaM cmpacna g
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_a9106d4a_cd6f_477c_9db4_4dae844eeb06
name: LDHAL6B
type: Species
is encoded by: hsa:92483
is: Q9BYZ2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_ba679b46_1c85_44e2_9a1f_a94d5a6a41e3
is encoded by: hsa:10841
initial concentration: NaN
type: Species
name: FTCD
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_ea84c4af_a9b3_4322_b071_d3f7f45bfe3c
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5297
type: Species
constant: false
is: B4DYG5
name: PI4KA

metaM dolp U c
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57683
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_c6e7e630_7554_405e_badb_25909a3d6713
constant: false
is encoded by: hsa:AI440329
name: _AI440329_1_r
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r0186
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
modifier: MODEL1310110048#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
kinetic law: MODEL1310110048#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_9933942d_38db_4f0b_8e22_83564284b44e
name: SLC7A8
type: Species
initial concentration: NaN
is: Q9UHI5
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:23428
is: SBO:0000252
initial amount: NaN

metaR r2139
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaR r1617
kinetic law: MODEL1310110048#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CRNtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
product: MODEL1310110048#
name: carnitine transport peroxisome to mitochondria
type: Reaction
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR 7DHFtl
is described by: ECO:0000000
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
is: SBO:0000185
name: 7-glutamyl-DHF transport, lysosomal
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_9a03b943_1d8d_48b4_800f_b7b81b2dbfc5
name: ENTPD8
is: SBO:0000252
is encoded by: hsa:377841
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: Q5MY95
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_3199fa54_ed6e_473f_8cf0_c05578fc2fd5
type: Species
is: P36957
name: DLST
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1743
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_4e595853_6968_46fb_953f_261ed108dc34
constant: false
boundary condition: true
is: F8WDN9
has only substance units: false
is encoded by: hsa:27068
type: Species
name: PPA2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_257b0c51_ada4_404d_88d5_c64689021c14
has only substance units: false
is encoded by: hsa:6487
boundary condition: true
name: ST3GAL3
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: Q96L53
is: SBO:0000252

metaM dgdp n
type: Species
boundary condition: false
is: CHEBI:58595
initial amount: NaN
is: HMDB00960
name: dGDP(2-)
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_fa6661ca_7474_4fe3_ae15_6355c39a0865
constant: false
is encoded by: hsa:60482
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9GZV3
has only substance units: false
name: SLC5A7
boundary condition: true

metaR DINt
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
fast: false
name: deoxyinosine transport via diffusion
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR SADT
modifier: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction
reversible: false
name: sulfate adenylyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_f5e5c65c_4468_4133_a4a5_f72d7b64e9aa
is: Q9H845
name: ACAD9
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:28976
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM pmtcrn m
has only substance units: false
constant: false
is: CHEBI:17490
initial amount: NaN
is: HMDB00222
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
name: L-palmitoylcarnitine
type: Species

metaR r0797
is described by: ECO:0000000
modifier: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is: SBO:0000176
reactant: MODEL1310110048#
type: Reaction
fast: false
name: glycine N-choloyltransferase EC:2.3.1.65
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaR RE3627M
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
name: RE3627
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000

metaR r1544
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110048#
fast: false
reversible: true
type: Reaction
product: MODEL1310110048#

metaR GALt4
kinetic law: MODEL1310110048#
is: SBO:0000185
type: Reaction
name: galactose transport via sodium symport
modifier: MODEL1310110048#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#

metaM mal L e
has only substance units: false
constant: false
is: HMDB00156
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: CHEBI:15589
initial concentration: 1.0
initial amount: NaN
name: (S)-malate(2-)

metaM glyc S c
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: 0
is: CHEBI:33871
type: Species
constant: false
has only substance units: false
name: (S)-Glycerate
is: HMDB06372
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR ATP1ter
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000
name: ADP/ATP transporter, endoplasmic reticulum
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR BILIRUBtr
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: lipid, flip-flop intracellular transport

metaR r0399
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
modifier: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
reversible: true
reactant: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
fast: false

metaR 4HOXPACDOX NADP
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
is: SBO:0000176
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
is described by: ECO:0000304
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
type: Reaction

metaR DESAT18 8
reversible: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269

metaR CITtbm
is described by: ECO:0000269
reactant: MODEL1310110048#
name: citrate transport, mitochondrial
reversible: true
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110048#

metaR r2136
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reversible: false

metaR LYSOXp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: L-lysine oxidase, peroxisomal
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_779eb5c2_82bd_4d8b_9e39_d93444c572d7
is: O00750
boundary condition: true
name: PIK3C2B
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:5287
initial amount: NaN
type: Species

metaR ASCBOX
reversible: false
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: ascorbic acid oxidase
is described by: ECO:0000000
is: SBO:0000176

metaM citr L c
name: L-citrulline
boundary condition: false
type: Species
has only substance units: false
constant: false
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16349
is: SBO:0000247

metaM mi134p c
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01143
boundary condition: false
is: CHEBI:58414
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR DESAT20 2
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000

metaM dgdp m
name: dGDP(2-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:58595
constant: false
is: SBO:0000247
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
has only substance units: false

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a0477d57_55bf_4d9c_a1c5_854048b6d4c4
boundary condition: true
constant: false
initial amount: NaN
name: FH
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2271
initial concentration: NaN
is: P07954
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_a4f696f1_92ce_40f4_946b_6d15a2cfefee
initial concentration: NaN
is: Q9NPB1
is encoded by: hsa:56953
name: NT5M
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM peamn c
type: Species
constant: false
has only substance units: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial amount: NaN
initial concentration: 1.0
name: 2-phenylethanaminium
is: CHEBI:225237
is: SBO:0000247
is: HMDB12275
boundary condition: false

metaR THYOXt
fast: false
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110048#
name: T4 transport via bicarbonate countertransport
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
is described by: ECO:0000269
type: Reaction

metaM prostgd2 c
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57406
name: prostaglandin D2(1-)
has only substance units: false
is: HMDB01403
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR DCSPTN1CPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110048#
reversible: false
fast: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase

metaR r0830
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR r0796
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
fast: false

metaM ile L m
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00172
name: L-isoleucine
is: CHEBI:17191

metaM dece3coa m
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
name: 3-decenoylcoa

metaR ASCBt4
fast: false
type: Reaction
reactant: MODEL1310110048#
name: L-ascorbate transport via proton symport
reversible: true
is: SBO:0000185
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269

metaR L LACt4r
name: L-lactate reversible transport via sodium symport
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
is: SBO:0000185

metaM ksi pre20 g
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 20
constant: false
is: SBO:0000247
type: Species
is: CHEBI:28067
notes: FORMULA: C171H274N12O140S6X CHARGE: -7

metaR r1619
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_bcd75141_4dce_455c_baa0_3dfd947d3602
constant: false
name: ACSS1
initial concentration: NaN
is: Q9NUB1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:84532

metaR FAOXC12C10x
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

metaR r2137
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
fast: false
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM gdp c
is: CHEBI:58189
has only substance units: false
is: SBO:0000247
name: GDP
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
initial concentration: 1.0
is: C00035
initial amount: NaN
is: HMDB01201

metaM ump c
is: HMDB00288
is: C00105
is: SBO:0000247
constant: false
name: UMP
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57865

metaM m8masn r
notes: FORMULA: C70H117N2O55X CHARGE: 0
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
is: C05876
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_7d6d5a9b_08d2_4c3d_a66a_aaa2130cfcb3
is: SBO:0000252
is encoded by: hsa:115111
initial concentration: NaN
is: Q8TE54
name: SLC26A7
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR RE1519M
reactant: MODEL1310110048#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
fast: false
product: MODEL1310110048#
reversible: true
is: SBO:0000176
name: RE1519
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR r2094
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
modifier: MODEL1310110048#
product: MODEL1310110048#

metaM docohexcoa m
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: HMDB02288
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: 2,4,7,10,13,16-docosahexenoylcoa

metaR 4MOPte
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 4-methyl-2-oxopentanoate
is: SBO:0000185
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000134
reversible: true

metaR MM8Cg
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
modifier: MODEL1310110048#
reversible: false
fast: false
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaR PEt
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
is described by: ECO:0000000
name: phosphatidylethanolamine transport
fast: false
is: SBO:0000185
product: MODEL1310110048#

metaR RE1796M
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: true
kinetic law: MODEL1310110048#
name: RE1796
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:

metaR r0839
is described by: ECO:0000000
product: MODEL1310110048#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.70
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110048#

metaR r0791
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
modifier: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
is: SBO:0000176
type: Reaction
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110048#

metaM g2m8mpdol U r
is: SBO:0000247
constant: false
is: CHEBI:59093
boundary condition: false
type: Species
initial amount: NaN
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
has only substance units: false

metaR DOLGLCP Lter
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
product: MODEL1310110048#
reversible: false
fast: false
reactant: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
type: Reaction

metaM glyc S e
name: (S)-Glycerate
is: CHEBI:33871
initial amount: NaN
boundary condition: false
is: HMDB06372
notes: FORMULA: C3H5O4 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaM dca c
boundary condition: false
is: HMDB04047
name: Decanoate (n-C10:0)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1
type: Species
constant: false
has only substance units: false
is: C14143
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_9fa54694_0b73_4ca0_8465_a366f15737b9
is encoded by: hsa:9481
initial amount: NaN
name: SLC25A27
is: F5GWR4
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_ac09778b_3db6_4332_88f2_6a1e22d52361
type: Species
is encoded by: hsa:50700
initial concentration: NaN
initial amount: NaN
is: Q9NYR8
boundary condition: true
constant: false
name: RDH8
has only substance units: false
is: SBO:0000252

metaR FAOXC185m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_083ab048_21ad_4636_bf10_6e9fb5e44b50
is encoded by: hsa:AI539321
is: SBO:0000252
type: Species
name: _AI539321_1_c
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_27021ddb_719b_41a4_a84b_af41224df763
is encoded by: hsa:3081
type: Species
is: SBO:0000252
is: Q93099
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: HGD
initial amount: NaN

metaM dctp n
is: CHEBI:16311
is: HMDB00998
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00458
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_2ed74944_5335_43e0_bace_786ba5e69244
is: SBO:0000252
name: ALDH3B1
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:221
is: P43353
initial amount: NaN
constant: false
type: Species

metaR PI4PLCn
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
kinetic law: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_52102fe2_6161_4b23_9c51_b3ba36eb5f3d
is: A8K003
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:5372
has only substance units: false
constant: false
name: PMM1
is: SBO:0000252
type: Species

metaR S6T7g
is described by: ECO:0000000
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110048#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110048#
type: Reaction

metaM 5aizc c
is: CHEBI:58564
is: HMDB06273
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: Species
initial amount: NaN
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
constant: false
boundary condition: false
is: SBO:0000247
is: C04751
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_3748793d_543c_4083_b7cf_f1f5b06df06e
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: PIGV
is: Q9NUD9
initial amount: NaN
is encoded by: hsa:55650

http://identifiers.org/biomodels.db/MODEL1310110048#_c45eacff_1269_4d48_a581_98dbbf082f58
is: SBO:0000252
is encoded by: hsa:8836
type: Species
constant: false
name: GGH
initial concentration: NaN
initial amount: NaN
is: Q92820
has only substance units: false
boundary condition: true

metaR ASNGLNNaEx
is described by: ECO:0000269
kinetic law: MODEL1310110048#
reversible: false
product: MODEL1310110048#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110048#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110048#

metaM prpp e
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58017
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_3f9e4f45_5835_4c6f_bb3e_b495e2c4e257
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P23634
type: Species
initial concentration: NaN
is encoded by: hsa:493
constant: false
name: ATP2B4
boundary condition: true

metaR r2093
is described by: ECO:0000000
modifier: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110048#
is: SBO:0000185
reversible: true
product: MODEL1310110048#
fast: false

metaR RE0583C
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110048#
is: SBO:0000176
reversible: true
reactant: MODEL1310110048#
name: RE0583
type: Reaction

metaR CO2tp
fast: false
is described by: ECO:0000000
name: CO2 peroxisomal transport
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: true

metaR HPYRRy
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.1.1.79
name: Hydroxypyruvate reductase (NADPH)
product: MODEL1310110048#
reversible: false
type: Reaction

metaR r0680
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
modifier: MODEL1310110048#
product: MODEL1310110048#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.137
reactant: MODEL1310110048#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
fast: false
reversible: true
is described by: ECO:0000000

metaR CYSTHRNaEx
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
modifier: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
reversible: true
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction

metaR r2092
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_86cbf057_fda2_4477_b2a7_7041844df4a2
is encoded by: hsa:8525
boundary condition: true
initial concentration: NaN
is: B7Z6M3
has only substance units: false
type: Species
name: DGKZ
is: SBO:0000252
initial amount: NaN
constant: false

metaM m2gacpail hs r
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
has only substance units: false
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:16038

metaM 1p3h5c m
boundary condition: false
is: HMDB01369
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:6151
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial amount: NaN

metaR ATP2ter
product: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110048#
is: SBO:0000185
fast: false
reactant: MODEL1310110048#

metaM ksi pre17 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 17
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:28067
type: Species
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_3233f7dd_5ea4_4104_aa5a_ac6be5148508
is: Q53XN1
boundary condition: true
initial concentration: NaN
name: COX8A
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:1351
type: Species

metaM dsmsterol r
is: HMDB02719
name: desmosterol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:17737
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r0242
kinetic law: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
product: MODEL1310110048#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
reversible: true

metaM dca e
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Decanoate (n-C10:0)
constant: false
type: Species
notes: FORMULA: C10H19O2 CHARGE: -1
is: C14143
is: HMDB04047
has only substance units: false
initial concentration: 1.0

metaR PTE4x
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
reversible: false
name: peroxisomal acyl-CoA thioesterase
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110048#

metaM etfrd m
notes: FORMULA: RH2 CHARGE: 0
is: CHEBI:16469
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: Electron transfer flavoprotein reduced
is: HMDB00151
type: Species
initial concentration: 1.0
boundary condition: false

metaM ha pre1 l
boundary condition: false
name: hyaluronan biosynthesis, precursor 1
has only substance units: false
is: CHEBI:16126
initial amount: NaN
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM HC01118 r
is: SBO:0000247
name: presqualene diphosphate(3-)
is: CHEBI:57310
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false
initial amount: NaN
type: Species

metaR r1540
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
type: Reaction
product: MODEL1310110048#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3f6108e7_0e8e_4af3_8bb9_8f34d331a381
initial concentration: NaN
is encoded by: hsa:83549
boundary condition: true
name: UCK1
is: SBO:0000252
constant: false
is: Q5JT09
type: Species
initial amount: NaN
has only substance units: false

metaR CO2tm
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
fast: false
product: MODEL1310110048#
reversible: true
name: CO2 transport (diffusion), mitochondrial
kinetic law: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_000eabd0_dc6e_45b5_9394_0593f8b4b02a
boundary condition: true
initial concentration: NaN
is encoded by: hsa:128
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ADH5
is: Q6IRT1
type: Species
constant: false

metaR CYSTA
fast: false
type: Reaction
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110048#
name: cysteine transaminase
kinetic law: MODEL1310110048#

metaR r0181
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110048#
modifier: MODEL1310110048#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110048#
type: Reaction
reversible: true

metaM CE4790 m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57923
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR PI45P4P
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176
reversible: false
product: MODEL1310110048#
is described by: ECO:0000000
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase

metaR CYTK5n
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear

metaM pmtcrn x
is: HMDB00222
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN
name: L-palmitoylcarnitine
type: Species
initial concentration: 1.0
is: CHEBI:17490
boundary condition: false

metaR CYSGLNNaEx
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
reversible: false
reactant: MODEL1310110048#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d6127bfc_3fad_4280_afca_d17fec8cf446
name: SLC24A2
constant: false
is: Q9UI40
is encoded by: hsa:25769
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_d934b1c7_aff0_4623_9d7e_3628e84a2add
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:1103
name: CHAT
boundary condition: true
is: P28329
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_5cc5c3f9_3626_4766_a47d_4e5aa768f352
initial amount: NaN
is encoded by: hsa:AA081045
name: _AA081045_1_c
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaR r2090
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0722
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.3.12
is: SBO:0000176
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
modifier: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110048#

metaR DOLPGT2 Uer
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110048#
reversible: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is version of: http://identifiers.org/ec-code/2.4.1.265
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176

metaR NAGA2ly
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.49
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
name: N-acetylgalactosaminidase, alpha-
reversible: false
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3de750da_f4cc_41db_860e_e0c7a64a1a04
type: Species
boundary condition: true
name: COL4A3BP
initial concentration: NaN
is encoded by: hsa:10087
is: SBO:0000252
has only substance units: false
is: Q9Y5P4
constant: false
initial amount: NaN

metaM pd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
constant: false
is: HMDB06500
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
name: Previtamin D3

metaM nh4 x
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
initial concentration: 1.0
is: C01342
is: HMDB00051
initial amount: NaN
is: CHEBI:28938
type: Species
name: Ammonium
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_59cd6986_ef37_483d_bd01_9c0b74abdf3d
is: Q542Y6
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PLA2G12A
is encoded by: hsa:81579

http://identifiers.org/biomodels.db/MODEL1310110048#_c70792f3_49aa_4a53_8c42_dd36e6ca59c3
is encoded by: hsa:343
initial amount: NaN
type: Species
name: AQP8
is: SBO:0000252
constant: false
boundary condition: true
is: O94778
initial concentration: NaN
has only substance units: false

metaR r2098
kinetic law: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true
fast: false

metaM citr L m
is: SBO:0000247
is: CHEBI:16349
is: HMDB00904
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
type: Species
name: L-citrulline

http://identifiers.org/biomodels.db/MODEL1310110048#_c8309988_88a1_4a65_a454_b3f1abec6a70
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: _H77542_1_c
is encoded by: hsa:H77542

metaR r2130
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
is: SBO:0000185
product: MODEL1310110048#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_c50ef1c6_8a16_4b9f_86e4_0408f628c7d5
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3162
name: HMOX1
initial concentration: NaN
is: Q6FH11

metaR RE3000M
name: RE3000
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110048#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
reactant: MODEL1310110048#
is: SBO:0000185

metaR r0578
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
kinetic law: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110048#
modifier: MODEL1310110048#

metaM orn e
initial amount: NaN
has only substance units: false
type: Species
is: C01602
initial concentration: 1.0
is: HMDB00214
is: SBO:0000247
name: Ornithine
constant: false
boundary condition: false
is: CHEBI:0
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaM dcsptn1coa m
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
initial amount: NaN
type: Species
is: C16173

metaR r0683
fast: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_040cc1ed_0073_4d28_ae71_d30fef48f534
type: Species
initial concentration: NaN
boundary condition: true
is: P61457
initial amount: NaN
constant: false
is: SBO:0000252
name: PCBD1
is encoded by: hsa:5092
has only substance units: false

metaR HSD17B4x
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
fast: false
modifier: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
name: hydroxysteroid (17-beta) dehydrogenase 4

metaR r0836
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110048#

metaR r0579
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
product: MODEL1310110048#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/1.13.11.19
reactant: MODEL1310110048#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true
fast: false

metaM cmpacna n
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57812
initial concentration: 1.0
type: Species
name: CMP-N-acetyl-beta-neuraminate(2-)

metaR RE2660N
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
is: SBO:0000176
name: RE2660
reactant: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#

metaR FAOXC14C12m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaM gal e
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
boundary condition: false
name: D-Galactose
initial amount: NaN
constant: false
is: C00124
type: Species
is: CHEBI:0
has only substance units: false

metaR r2131
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction

metaR PI45PLC
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
type: Reaction

metaR r2097
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110048#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000

metaM 4mlacac c
constant: false
is: CHEBI:17105
is: SBO:0000247
is: HMDB02052
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
name: 4-maleylacetoacetate
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM core3 g
initial amount: NaN
is: CHEBI:16250
name: Core 3
constant: false
has only substance units: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR UDPGD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.22
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
product: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
name: UDPglucose 6-dehydrogenase
fast: false

metaM acac m
type: Species
initial amount: NaN
is: CHEBI:13705
initial concentration: 1.0
name: acetoacetate
boundary condition: false
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
is: HMDB00060
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_02dd9b63_2399_4183_af1c_5a16072b9618
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3098
type: Species
has only substance units: false
constant: false
name: HK1
initial amount: NaN
is: Q59FD4

metaR DHFR
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: dihydrofolate reductase
type: Reaction
reactant: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000254
fast: false

metaR PI4PLC
modifier: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
name: phosphatidylinositol 4-phosphate phospholipase C
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
fast: false
reactant: MODEL1310110048#

metaR PI3P3Pn
product: MODEL1310110048#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000176
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
kinetic law: MODEL1310110048#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD

metaR r0033
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110048#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_a1342910_6087_4a6b_ad52_66f1a440fded
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51292
has only substance units: false
type: Species
boundary condition: true
constant: false
is: Q86T14
name: GMPR2

metaR r0236
reversible: true
reactant: MODEL1310110048#
type: Reaction
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#

metaR ACGAMPM
product: MODEL1310110048#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
fast: false
name: phosphoacetylglucosamine mutase
is version of: http://identifiers.org/ec-code/5.4.2.3
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_d1484dce_a313_4bce_9db3_bbe3adacca1c
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6482
type: Species
name: ST3GAL1
constant: false
is: SBO:0000252

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaM leugly c
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Leucylglycine
is: http://identifiers.org/pubchem.compound/97364
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C8H16N2O3 CHARGE: 0

metaR M16NTg
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.143
type: Reaction
reactant: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110048#
product: MODEL1310110048#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD

metaR r0604
reactant: MODEL1310110048#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
modifier: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
product: MODEL1310110048#

metaR r0724
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
reactant: MODEL1310110048#
is described by: ECO:0000000
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true
product: MODEL1310110048#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_92a6f306_82f9_4dbb_b925_d32aaab1ea34
is: SBO:0000252
constant: false
initial amount: NaN
is: Q9UJS0
type: Species
name: SLC25A13
has only substance units: false
boundary condition: true
is encoded by: hsa:10165
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_21bd1300_324d_4894_8c51_8ee1e7395b9c
is encoded by: hsa:221
name: ALDH3B1
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: P43353
initial concentration: NaN
constant: false
is: SBO:0000252

metaM pail5p hs n
initial amount: NaN
is: CHEBI:57795
constant: false
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR r2096
product: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_a736061e_7f9c_46ef_9635_c23db323082d
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: NDUFB7
type: Species
is encoded by: hsa:4713
boundary condition: true
has only substance units: false
is: P17568

http://identifiers.org/biomodels.db/MODEL1310110048#_e1e653de_ca5d_489a_80d0_97e5f30881c6
initial amount: NaN
is encoded by: hsa:4715
type: Species
initial concentration: NaN
is: Q9Y6M9
boundary condition: true
name: NDUFB9
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_4318c7b1_05cf_48aa_8386_9a26f3218aa7
type: Species
is encoded by: hsa:55825
name: PECR
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: Q9BY49
boundary condition: true

metaR GLYCt
is: SBO:0000185
name: glycerol transport via channel
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
product: MODEL1310110048#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110048#

metaR CYTK10
modifier: MODEL1310110048#
name: cytidylate kinase (CMP,dGTP)
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR BHBt
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: (R)-3-Hydroxybutanoate transport via H+ symport
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaM orot5p c
boundary condition: false
constant: false
is: HMDB00218
is: CHEBI:57538
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: C01103
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Orotidine 5'-phosphate
has only substance units: false
initial amount: NaN

metaM etfox m
is: HMDB00151
is: CHEBI:16469
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: R CHARGE: 0
is: SBO:0000247
constant: false
name: Electron transfer flavoprotein oxidized
initial amount: NaN
initial concentration: 1.0

metaM CE2418 m
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:28387
has only substance units: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
initial amount: NaN
is: HMDB11123
is: SBO:0000247

metaR DM atp c
reversible: false
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)
reactant: MODEL1310110048#

metaR r0246
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
type: Reaction

metaR G16MT U
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_d48b4e9e_f161_4a20_a8b1_46aee39639c7
constant: false
is: P19440
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2678
has only substance units: false
boundary condition: true
name: GGT1
initial concentration: NaN

metaR r0603
modifier: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
reactant: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.12
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:

metaR M1316Mg
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.114
reversible: false
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
fast: false

metaR r0838
is version of: http://identifiers.org/ec-code/3.1.2.4
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
modifier: MODEL1310110048#
fast: false
name: Free diffusion
reactant: MODEL1310110048#
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#

metaR PTCRTD
is: SBO:0000185
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110048#
name: diffusion of putriscine into the endothelial cells
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
reversible: true
type: Reaction
product: MODEL1310110048#

metaR CBR2
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: Carbonyl reductase [NADPH] 1
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
type: Reaction
product: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.189
reactant: MODEL1310110048#
modifier: MODEL1310110048#

metaR r2095
is described by: ECO:0000000
product: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110048#
fast: false
reversible: true

metaM prpp c
is: CHEBI:58017
is: SBO:0000247
is: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
constant: false
is: HMDB00280
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaM gln L m
is: SBO:0000247
is: HMDB00641
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:18050
initial amount: NaN
type: Species
name: L-glutamine
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaR MELATNOX
is version of: http://identifiers.org/ec-code/1.14.13.48
reactant: MODEL1310110048#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
name: Melatonin:NADP oxidoreductase
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
is version of: http://identifiers.org/ec-code/1.14.14.1
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR ASNCYSNaEx
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110048#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is described by: ECO:0000269
reversible: false

metaM gacpail hs r
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01401
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: C00092
is: CHEBI:61548
initial concentration: 1.0
name: glucosaminyl-acylphosphatidylinositol
type: Species
has only substance units: false

metaM gal c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: D-Galactose
is: HMDB00143
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
is: C00124
is: CHEBI:0

metaR CYSO
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269
reactant: MODEL1310110048#
type: Reaction
fast: false
name: cysteine oxidase
is version of: http://identifiers.org/ec-code/1.13.11.20
is: SBO:0000176
reversible: false
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3c263eec_549f_4501_bc95_bb10826077dd
initial concentration: NaN
initial amount: NaN
name: CA14
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:23632
boundary condition: true
is: A8K3J4

http://identifiers.org/biomodels.db/MODEL1310110048#_03e64cb0_c66b_49c9_bc56_a16123bf6af1
is encoded by: hsa:80347
boundary condition: true
name: COASY
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q13057
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_a26d3036_a599_4e4d_a589_fd619481ee77
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: O43772
is encoded by: hsa:788
is: SBO:0000252
boundary condition: true
name: SLC25A20
constant: false

metaR CYTK11
product: MODEL1310110048#
is: SBO:0000176
type: Reaction
name: cytidylate kinase (dCMP,dGTP)
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR GAO1g
reversible: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
name: Ganglioside O-acetylation
type: Reaction
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaM dgdp c
constant: false
has only substance units: false
is: C00361
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
is: CHEBI:58595
name: dGDP

metaR r0245
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110048#
reversible: true
fast: false
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72

http://identifiers.org/biomodels.db/MODEL1310110048#_01b794d7_5ae5_4aa5_a88b_bdfef88e38d7
initial concentration: NaN
constant: false
is encoded by: hsa:R39999
name: _R39999_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_45370eae_7b99_4231_8cf8_11cc746baa47
has only substance units: false
is encoded by: hsa:AI697028
name: _AI697028_1_e
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaR r0450
modifier: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39

metaR r1761
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_f975d740_29eb_439f_8e1e_0802e1749c02
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: EARS2
is: Q5JPH6
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:124454

metaM 2maacoa m
constant: false
name: 2-methylacetoacetyl-CoA(4-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57335
boundary condition: false
type: Species
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157

http://identifiers.org/biomodels.db/MODEL1310110048#_38d83054_cb51_4dcf_ab6c_31912e94d48c
initial concentration: NaN
has part: P23921
is: SBO:0000297
initial amount: NaN
name: RRM1:RRM2
is encoded by: hsa:6240
is encoded by: hsa:6241
type: Species
constant: false
has only substance units: false
boundary condition: true
has part: P31350

metaM glypro c
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/79101
name: Glycylproline
boundary condition: false
is: HMDB00721
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H12N2O3 CHARGE: 0
constant: false

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM HC01406 m
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
is: CHEBI:28264
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 3-Oxooctanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110048#_cedb2929_e90c_40b4_a145_b6eba8984357
constant: false
initial amount: NaN
name: HADHB
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:3032
boundary condition: true
is: P55084

metaM oxa m
is: CHEBI:30623
name: oxalate(2-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB02329

metaM utp e
name: UTP(4-)
is: HMDB00285
constant: false
initial amount: NaN
is: CHEBI:46398
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_423d2a24_e92d_43e9_8476_3fd5d5d581bb
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q01581
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: HMGCS1
is encoded by: hsa:3157

metaR FCOAH
is: SBO:0000176
reactant: MODEL1310110048#
reversible: false
product: MODEL1310110048#
name: formyl coa hydrolase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#

metaM ksi pre31 g
name: keratan sulfate I biosynthesis, precursor 31
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: C00130
boundary condition: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
initial concentration: 1.0
is: HMDB00175
has only substance units: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110048#_950e11d7_1e46_4a8f_a1d3_fee9a5b5ec9b
is: B7Z5G2
initial concentration: NaN
name: GBA
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2629

metaM b2coa m
boundary condition: false
has only substance units: false
is: HMDB02009
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57332
initial amount: NaN
name: crotonoyl-CoA(4-)
initial concentration: 1.0

metaM ksii core4 e
is: CHEBI:17268
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
is: HMDB00211
initial amount: NaN
name: keratan sulfate II (core 4-linked)
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM 2ddecdicoa m
initial concentration: 1.0
initial amount: NaN
name: 2,6-dodecadienoylcoa
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
is: HMDB11123
is: C05279
is: SBO:0000247

metaM ppa c
type: Species
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
constant: false
is: HMDB00237
is: SBO:0000247
initial amount: NaN
is: CHEBI:17272
initial concentration: 1.0
name: propionate
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b32951a4_dcb4_405f_aa53_850efee96ea0
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51292
initial amount: NaN
constant: false
name: GMPR2

http://identifiers.org/biomodels.db/MODEL1310110048#_2df1f3d1_f5f8_44c2_99fe_550918c47a51
initial concentration: NaN
initial amount: NaN
is: Q9UHV8
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:29124
name: LGALS13

metaR r1760
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110048#
is: SBO:0000185
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR FAOXC225C204m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM ump n
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57865
name: UMP(2-)
is: HMDB00288
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_9c2d6dc1_ab37_4261_b673_d0012c48235b
name: NDUFS8
has only substance units: false
is: O00217
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4728

metaM 3sala m
is: CHEBI:61085
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
has only substance units: false
name: 3-sulfino-L-alanine (1-)
boundary condition: false
initial concentration: 1.0
is: C00606

http://identifiers.org/biomodels.db/MODEL1310110048#_e5ab0b20_de21_406f_855f_5ee974f030e9
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: ALG6
is encoded by: hsa:29929
initial concentration: NaN
is: Q9Y672

http://identifiers.org/biomodels.db/MODEL1310110048#_38ec1c83_74c1_47a0_afbe_9a466a309a94
has only substance units: false
constant: false
is encoded by: hsa:3155
is: Q6IBC0
initial amount: NaN
name: HMGCL
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaM adpcoa x
name: adipoylcoa
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB04047
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
initial amount: NaN
is: C14143

metaM ksi pre25 g
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247
constant: false
is: HMDB00175
initial amount: NaN
is: C00130
type: Species
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 25

metaM CE5126 x
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
name: (2R)-pristanoyl-CoA
has only substance units: false
is: CHEBI:12947
boundary condition: false
initial concentration: 1.0

metaR DNDPt17m
reversible: false
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110048#
modifier: MODEL1310110048#
name: dUDP transport via dCDP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110048#
fast: false

metaR G14T16g
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
product: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_21c7ac12_1704_4571_9aa6_bcc5b9186435
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ETFA
constant: false
is: P13804
is encoded by: hsa:2108
type: Species
initial amount: NaN

metaM mal L x
is: SBO:0000247
is: HMDB00156
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: (S)-malate(2-)
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
type: Species

metaR GLXtp
type: Reaction
kinetic law: MODEL1310110048#
fast: false
reversible: true
reactant: MODEL1310110048#
is: SBO:0000185
name: glyoxylate transport, peroxisomal
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110048#_678783de_a566_4448_96de_05080872c7e1
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: Q16842
type: Species
has only substance units: false
is encoded by: hsa:6483
initial concentration: NaN
name: ST3GAL2

http://identifiers.org/biomodels.db/MODEL1310110048#_c7a5a82e_9582_4233_9e16_9e550f012275
type: Species
name: UCP3
is encoded by: hsa:7352
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR FUMTSULtm
reactant: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reversible: true
name: Fumarate:thiosulfate antiport, mitochondrial
is: SBO:0000185
product: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_19db6ff0_c6a7_43be_b088_2893cad19b50
name: GSTZ1
is: SBO:0000252
is encoded by: hsa:2954
is: A6NED0
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_a5449bbe_949e_4ed5_8291_7978b7813967
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC16A7
is: Q8NEM3
has only substance units: false
constant: false
is encoded by: hsa:9194
type: Species

metaR SPHMYLNtg
kinetic law: MODEL1310110048#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
name: sphingomyelin intracellular transport
product: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR RE1522M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110048#
is: SBO:0000176
name: RE1522
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_949d201a_0196_4d18_829e_e8068b95fcdf
initial concentration: NaN
is encoded by: hsa:9843
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: HEPH
has only substance units: false
initial amount: NaN
is: E9PHN8

http://identifiers.org/biomodels.db/MODEL1310110048#_fdc16e8b_ac19_4adc_ab06_7d98e3174fc5
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: NEU1
is: SBO:0000252
is: Q99519
initial concentration: NaN
constant: false
is encoded by: hsa:4758

metaR DNDPt25m
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
fast: false
reactant: MODEL1310110048#
reversible: false
product: MODEL1310110048#
name: dTDP transport via dCDP antiport
is: SBO:0000185
modifier: MODEL1310110048#

metaR C10DCCACT
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a25028c9_5cbb_44c6_8bab_7c136b38256f
is encoded by: hsa:84720
has only substance units: false
initial concentration: NaN
type: Species
has part: Q6IB04
is encoded by: hsa:5281
is: SBO:0000297
name: PIGF:PIGO
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_acf19648_e079_44c2_ac33_8bad771cde04
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:93010
is: Q8NFL0
name: B3GNT7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_d43f46a3_968c_43a4_b4e1_ec15a112dacd
name: SLC23A1
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9963
boundary condition: true
has only substance units: false

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_fa37ad92_eaae_4f51_97ab_0ca11e2fa8bd
has part: P36957
has part: O00330
initial concentration: NaN
is encoded by: hsa:1738
is encoded by: hsa:8050
constant: false
has only substance units: false
name: DLD:DLST:OGDH:PDHX
has part: P09622
has part: Q02218
type: Species
is encoded by: hsa:4967
initial amount: NaN
boundary condition: true
is: SBO:0000297
is encoded by: hsa:1743

metaM g1p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
name: D-Glucose 1-phosphate
type: Species
is: SBO:0000247
boundary condition: false
is: C00103
is: HMDB01586
initial amount: NaN
constant: false
is: CHEBI:58601
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_aae6f85f_73be_4b06_b8df_fd14615aac3e
boundary condition: true
is encoded by: hsa:6390
is: P21912
constant: false
name: SDHB
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM 7dhf l
initial amount: NaN
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB06559
name: heptaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110048#_e22e4490_3c1d_48e2_a6ab_f89107bcde41
is: SBO:0000252
is encoded by: hsa:5334
initial concentration: NaN
initial amount: NaN
name: PLCL1
boundary condition: true
type: Species
has only substance units: false
is: Q15111
constant: false

metaR ME1m
reversible: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
name: malic enzyme (NAD), mitochondrial
modifier: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
is described by: ECO:0000000
fast: false

metaR r2099
is described by: ECO:0000000
product: MODEL1310110048#
fast: false
type: Reaction
kinetic law: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110048#
reactant: MODEL1310110048#

metaM clpndcoa c
has only substance units: false
is: SBO:0000247
is: C16166
initial concentration: 1.0
constant: false
is: HMDB06267
name: clupanodonyl CoA
is: http://identifiers.org/pubchem.compound/47205476
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
type: Species
boundary condition: false

metaM ha pre1 e
name: hyaluronan biosynthesis, precursor 1
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
constant: false
is: CHEBI:16126

metaM lneldccoa c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: linoelaidyl coenzyme A
has only substance units: false
constant: false
is: CHEBI:3793
boundary condition: false
type: Species
is: HMDB01322
notes: FORMULA: C39H62N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110048#_ac5cf1b0_f41b_4d06_8d9d_cb70f81220af
is: B4DK61
has only substance units: false
is encoded by: hsa:51
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ACOX1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_fe6446f3_2351_48ec_aa00_26adf88d4153
is encoded by: hsa:5634
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: PRPS2
is: P11908
boundary condition: true
initial concentration: NaN

metaM ppa e
name: propionate
is: HMDB00237
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_fbf94594_d110_4b25_a9a5_dc0cb72b5c71
boundary condition: true
name: NOS3
is: A0S0A7
is encoded by: hsa:4846
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaM 7dhf m
name: heptaglutamyl folate (DHF)
is: SBO:0000247
type: Species
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB06559
constant: false

metaM ahdt e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
is: CHEBI:58462
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
constant: false
is: HMDB00980
type: Species
has only substance units: false

metaM 5thf e
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial amount: NaN
is: HMDB06487
name: pentaglutamyl folate (THF)

http://identifiers.org/biomodels.db/MODEL1310110048#_de9a82c8_ac57_4ef2_b6e1_66b38bb38c0a
is encoded by: hsa:51733
constant: false
type: Species
boundary condition: true
name: UPB1
is: B3KNC1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_724120e5_b52d_4f47_b6f7_707682212555
boundary condition: true
initial concentration: NaN
name: QPRT
has only substance units: false
type: Species
is: Q15274
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:23475

metaR CERT2gt
name: ceramide transport protein
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reversible: true
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR SUCCTD
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM dcsptn1coa c
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
constant: false
is: HMDB06513
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: C16173
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205483

http://identifiers.org/biomodels.db/MODEL1310110048#_d6107346_6969_4087_b3d0_41759ce43353
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA977580
has only substance units: false
name: _AA977580_1_c
boundary condition: true
constant: false
type: Species

metaR PYRt2r
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
product: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
name: pyruvate reversible transport via proton symport
reversible: true
is: SBO:0000185
is described by: ECO:0000269

metaR GLYCtm
fast: false
type: Reaction
name: glycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185

metaR MG2er
product: MODEL1310110048#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reactant: MODEL1310110048#

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57795
constant: false
has only substance units: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA

metaR DGK1
modifier: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
name: deoxyguanylate kinase (dGMP:ATP)
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#

metaR H2O2tp
name: hydrogen peroxide peroxisomal transport via diffusion
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD

metaR PHYCBOXL
kinetic law: MODEL1310110048#
name: L-Phenylalanine carboxy-lyase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110048#
reversible: false
product: MODEL1310110048#
is described by: ECO:0000212

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_16295846_6f1b_4955_845d_fee0aa205380
initial amount: NaN
name: PSAT1
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29968
is: SBO:0000252
type: Species
has only substance units: false

metaR CMPACNAtg
modifier: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110048#
name: CMP-Sia Golgi transport via CMP antiport
is: SBO:0000185

metaM ppcoa x
initial amount: NaN
is: C00100
is: SBO:0000247
initial concentration: 1.0
is: HMDB01275
has only substance units: false
is: CHEBI:57392
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_9a965bc8_86d7_4a26_b58e_906e43948f49
is: SBO:0000252
initial amount: NaN
type: Species
name: _R06874_1_r
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:R06874
initial concentration: NaN

metaR GGH 6DHFl
kinetic law: MODEL1310110048#
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
reversible: false
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110048#_29882c9e_00c5_4b6a_95ee_97c51dca3cd0
is: P00414
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4514
boundary condition: true
name: COX3
constant: false

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_812ede6b_cc76_4f4c_8909_5a72b534cb03
is: SBO:0000252
is: P30837
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ALDH1B1
constant: false
is encoded by: hsa:219
has only substance units: false
type: Species

metaM g6p c
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01401
is: CHEBI:61548
constant: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
initial amount: NaN
type: Species
is: C00092

metaR GTMLTe
modifier: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
product: MODEL1310110048#
fast: false
reactant: MODEL1310110048#
name: g-glutamyltransferase (e)

http://identifiers.org/biomodels.db/MODEL1310110048#_3a88a7b8_e93d_4893_b311_baf107d05ef8
constant: false
is encoded by: hsa:2678
has only substance units: false
initial amount: NaN
name: GGT1
is: P19440
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_d30582e9_8914_4a95_92cc_16af43673cf0
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PANK3
is: SBO:0000252
is: Q9H999
type: Species
boundary condition: true
is encoded by: hsa:79646

metaR G14T5g
kinetic law: MODEL1310110048#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110048#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#

metaM HC01415 m
initial amount: NaN
name: (2E)-Octenoyl-CoA
is: CHEBI:27537
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
boundary condition: false
initial concentration: 1.0
type: Species

metaM ump r
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
initial amount: NaN
is: CHEBI:57865
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: UMP
constant: false
has only substance units: false
type: Species

metaM sbt D e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial concentration: 1.0
constant: false
is: HMDB00247
has only substance units: false
initial amount: NaN
name: D-glucitol
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_5020e07b_393f_4875_be41_9a4cfa1fd81b
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84720
name: PIGO
boundary condition: true
initial amount: NaN
is: Q8TEQ8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_3a0971fe_92e5_49d7_93f0_eb7adba2f24c
is encoded by: hsa:212
name: ALAS2
is: Q5JZF5
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_f0ca6105_b1a1_4cea_9b2a_dab263de720b
has only substance units: false
is encoded by: hsa:5052
constant: false
name: PRDX1
initial amount: NaN
boundary condition: true
is: Q06830
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_4269ac2b_9686_48a2_8b54_d916041271fe
boundary condition: true
name: GALNT13
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q8IUC8
is encoded by: hsa:114805
constant: false
has only substance units: false

metaM ksi pre1 g
constant: false
boundary condition: false
is: HMDB00175
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 1

http://identifiers.org/biomodels.db/MODEL1310110048#_4a61ad34_ce5c_42a8_a456_d9ad5f5eca0a
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q548A7
has only substance units: false
name: SLC26A6
is encoded by: hsa:65010
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_ca86cb9e_2cf4_44c5_9bdd_9565189be69b
is encoded by: hsa:8398
name: PLA2G6
constant: false
initial amount: NaN
has only substance units: false
is: O60733
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_bad9652e_4899_46a5_9dec_f5986efd3b5f
is encoded by: hsa:1593
name: CYP27A1
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q02318

metaR r0931
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110048#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Transport reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110048#_dbede5f4_0ba2_409b_907e_f99b4b048cbb
is encoded by: hsa:7296
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: TXNRD1
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaR MDHm
is: SBO:0000176
reactant: MODEL1310110048#
name: malate dehydrogenase, mitochondrial
reversible: true
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
is version of: http://identifiers.org/ec-code/1.1.1.37
type: Reaction

metaR BILDGLCURtr
type: Reaction
product: MODEL1310110048#
name: glucuronidated compound transport
fast: false
reversible: true
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185

metaM gln L e
is: CHEBI:18050
name: L-glutamine
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00641
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR NDPK4n
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaR HISD
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/4.3.1.3
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
fast: false
name: histidase
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_05fd23bb_3c1e_4cac_9a38_c2ea2d7b8b4b
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _BF195998_1_x
constant: false
is encoded by: hsa:BF195998

metaR r0027
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.39
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_0a40668b_58c1_4a91_8728_b3a0f3b27a1a
is: P27707
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: DCK
is encoded by: hsa:1633
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_11ebca2b_fcaf_44c0_8a65_e3c233d0b4a7
type: Species
is encoded by: hsa:93034
initial amount: NaN
name: NT5C1B
initial concentration: NaN
is: Q96P26
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR THMDt5le
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: thymidine transport (1:2 Na/Thymd cotransport)
is described by: ECO:0000134
fast: false
is: SBO:0000185
product: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction

metaM pail345p hs c
initial concentration: 1.0
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
constant: false
type: Species
has only substance units: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial amount: NaN
is: CHEBI:57836
is: SBO:0000247

metaM ksii core4 g
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01644
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
is: SBO:0000247
is: CHEBI:17140
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_dbf821b6_b4a5_4479_9d3f_9fa6ceaa6559
has only substance units: false
is: Q96T66
is encoded by: hsa:349565
initial amount: NaN
type: Species
name: NMNAT3
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM utp c
boundary condition: false
is: SBO:0000247
is: C00075
initial concentration: 1.0
type: Species
name: UTP
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
initial amount: NaN
constant: false
has only substance units: false

metaM dcyt n
type: Species
is: CHEBI:15698
name: 2'-deoxycytidine
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_3526bcb0_23b3_4c6d_a1e0_a446b8e43beb
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AU149534
initial amount: NaN
name: _AU149534_1_m

metaM 3hbcoa m
has only substance units: false
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: CHEBI:57316
boundary condition: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: HMDB01166
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaR AG13T15g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false

metaM lnlc r
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: CHEBI:30245
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00673
is: SBO:0000247
name: linoleate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_61cdd319_1fce_4ae9_aec2_9308982ea6a2
has only substance units: false
name: AK5
is: Q9Y6K8
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:26289
is: SBO:0000252

metaM gal l
is: SBO:0000247
constant: false
is: CHEBI:12936
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
boundary condition: false
name: D-galactose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:27969
initial amount: NaN
is: SBO:0000247
name: Mesaconyl-CoA
is: C06028
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_fa4fb668_977f_49e0_8464_5da1d0e7d76d
is encoded by: hsa:54677
has only substance units: false
name: CROT
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: E7EQF2
constant: false
boundary condition: true

metaM sbt D c
boundary condition: false
is: CHEBI:17924
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: D-glucitol
constant: false
is: HMDB00247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_11dcafdd_7346_4168_a25e_cdcfa706d40f
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9Y5B8
type: Species
name: NME7
has only substance units: false
constant: false
is encoded by: hsa:29922

metaR r2019
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_44ed5c4e_245d_4a1c_b120_b2666971a59a
boundary condition: true
is: Q86YU0
initial amount: NaN
constant: false
has only substance units: false
name: CA7
type: Species
is encoded by: hsa:766
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_0e8a55a2_8993_43d5_84f5_2c04f840278c
is encoded by: hsa:2686
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: GGT7
has only substance units: false
constant: false
is: A0PJJ9
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_0e5e30c5_889d_4b56_9bc5_11233ee73001
name: NME1
has only substance units: false
initial amount: NaN
constant: false
is: P15531
boundary condition: true
type: Species
is encoded by: hsa:4830
is: SBO:0000252
initial concentration: NaN

metaM dc2coa m
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
has only substance units: false
is: SBO:0000247
name: trans-Dec-2-enoyl-CoA
is: CHEBI:61406
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_dffd60d5_4dc1_49d5_84aa_52920ccc347f
initial concentration: NaN
initial amount: NaN
is: Q15849
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8170
name: SLC14A2

http://identifiers.org/biomodels.db/MODEL1310110048#_136d82b7_352a_4cbc_8686_53b9f84a43ef
is: SBO:0000252
is encoded by: hsa:5053
initial amount: NaN
has only substance units: false
is: P00439
boundary condition: true
constant: false
initial concentration: NaN
name: PAH
type: Species

metaM 7dhf e
type: Species
is: HMDB06559
initial concentration: 1.0
name: heptaglutamyl folate (DHF)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
initial amount: NaN
constant: false

metaR ADK1
modifier: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110048#
reversible: true
name: adenylate kinase
fast: false
type: Reaction

metaR RE1447M
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110048#
type: Reaction
name: RE1447
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaM bhb c
is: HMDB00011
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:10983
name: (R)-3-hydroxybutyrate

metaR ARGtiDF
name: L-arginine transport via diffusion (extracellular to cytosol)
reversible: false
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110048#_a6db3523_bb44_4b2b_bb00_61f047eac7b2
is: Q9Y617
is encoded by: hsa:29968
constant: false
initial concentration: NaN
boundary condition: true
name: PSAT1
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaM lnlc c
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: linoleate
is: CHEBI:30245
constant: false
is: HMDB00673
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_9ee4de17_b6bd_4460_856d_a67205a1d222
boundary condition: true
initial amount: NaN
initial concentration: NaN
has part: Q9BQL0
has only substance units: false
constant: false
is encoded by: hsa:594
is: SBO:0000297
type: Species
name: DBT:DLD:BCKDHA:BCKDHB

metaR r2353
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

metaR PYRt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
name: pyruvate mitochondrial transport via proton symport

metaM 44mctr r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17813
type: Species
is: HMDB01023
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false
boundary condition: false

metaR r1831
product: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110048#
type: Reaction
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000185

metaR PCHOLP hs
is described by: ECO:0000269
name: choline phosphatase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
kinetic law: MODEL1310110048#

metaM duri c
is: HMDB00012
type: Species
is: CHEBI:16450
constant: false
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00526
boundary condition: false

metaM gln L c
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00641
constant: false
boundary condition: false
name: L-glutamine
is: CHEBI:18050
initial concentration: 1.0
type: Species

metaR ASNtm
name: L-asparagine transport, mitochondrial
fast: false
is: SBO:0000185
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
type: Reaction
reversible: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_3210ce3a_503e_49d1_b74a_b74ce8ad9202
is encoded by: hsa:79837
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: B3KQV3
constant: false
is: SBO:0000252
name: PIP4K2C
initial amount: NaN

metaM cholcoaone x
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB06891
boundary condition: false
initial concentration: 1.0
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
type: Species
is: CHEBI:58507
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467

metaR FAOXC143C123m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR r2352
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#

metaR DNDPt9m
type: Reaction
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110048#
reactant: MODEL1310110048#
name: dADP transport via dTDP antiport
is described by: ECO:0000269

metaM cmpacna c
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:57812
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01176

metaR RE1447N
is described by: ECO:0000000
reactant: MODEL1310110048#
name: RE1447
kinetic law: MODEL1310110048#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
product: MODEL1310110048#

metaM ksii core4 l
is: HMDB01644
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: keratan sulfate II (core 4-linked)
is: CHEBI:17140
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4

metaR GLCURtly
product: MODEL1310110048#
reversible: true
name: glucuronate transport into lysososme
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is described by: ECO:0000269
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110048#

metaR THRGLNNaEx
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110048#
type: Reaction
reversible: false
is described by: ECO:0000269
product: MODEL1310110048#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_74fdaf1d_b07a_4fc2_8e71_91e5a4b58e4a
constant: false
initial amount: NaN
is: SBO:0000252
name: GBA
is: P04062
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2629
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_49a0b845_04e4_4a7f_bc02_abe597a97b2c
is: SBO:0000252
initial concentration: NaN
is: B4E0V8
name: HAL
constant: false
type: Species
has only substance units: false
is encoded by: hsa:3034
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_6650c899_b612_413d_a3c0_540a95d5a41f
initial concentration: NaN
has only substance units: false
name: NDUFS4
constant: false
is encoded by: hsa:4724
boundary condition: true
is: O43181
is: SBO:0000252
initial amount: NaN
type: Species

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR ALAt4
kinetic law: MODEL1310110048#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110048#
name: Alanine-Sodium symporter
modifier: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
reversible: false

metaR UDPACGALtl
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
name: udpacgal intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_33475c05_ad94_49df_b233_7aa427c5d3fd
is: B3KT19
name: PIK3R1
initial concentration: NaN
is encoded by: hsa:5295
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_d598301d_8e25_4c98_a691_4b16709b716e
boundary condition: true
is: P09622
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: DLD
initial amount: NaN
is encoded by: hsa:1738

metaM lneldccoa m
name: linoelaidyl coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
is: SBO:0000247
constant: false
is: HMDB01064
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_38dbbcc7_4498_4698_acbd_631be39e3b76
is encoded by: hsa:4967
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000297
name: DLD:DLST:OGDH:PDHX
has part: B4E3E9
initial concentration: NaN
constant: false

metaM utp n
type: Species
name: UTP(4-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
is: CHEBI:46398
boundary condition: false
is: SBO:0000247
constant: false

metaR r0932
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_20a20a52_b5d2_4b5b_be9b_ea47be93938a
type: Species
is: SBO:0000252
constant: false
is: B2RDU6
initial amount: NaN
name: MVK
is encoded by: hsa:4598
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM 7dhf c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: heptaglutamyl folate (DHF)
constant: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06559

metaM dump n
constant: false
is: CHEBI:246422
boundary condition: false
initial amount: NaN
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
type: Species
name: dUMP(2-)
initial concentration: 1.0
has only substance units: false

metaR ARACHDtr
name: intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110048#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185

metaR THRPHELAT2tc
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR ADK3
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110048#
name: adentylate kinase (GTP)
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR

metaR r2129
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#

metaR ALAGLYexR
reversible: true
is described by: ECO:0000304
product: MODEL1310110048#
name: L-alanine/glycine reversible exchange
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110048#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110048#

metaM lnlc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: linoleate
is: CHEBI:30245
constant: false
is: HMDB00673
initial amount: NaN
is: SBO:0000247

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM gdp g
is: HMDB01201
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58189
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
boundary condition: false
is: SBO:0000247

metaM m7mpdol U r
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
boundary condition: false
constant: false
is: CHEBI:37636
has only substance units: false
initial amount: NaN

metaR MTHGXLt
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reversible: false
name: Methylglyoxal transport (cytosol to extracellular)

http://identifiers.org/biomodels.db/MODEL1310110048#_55202af8_d556_4db2_9323_cf7a28c4204c
initial concentration: NaN
is encoded by: hsa:94005
type: Species
is: SBO:0000252
constant: false
is: Q8NBL9
has only substance units: false
boundary condition: true
initial amount: NaN
name: PIGS

http://identifiers.org/biomodels.db/MODEL1310110048#_65827563_7135_45af_ab82_5c42fd32d9f4
initial concentration: NaN
type: Species
is encoded by: hsa:5291
initial amount: NaN
constant: false
has only substance units: false
name: PIK3CB
boundary condition: true
is: SBO:0000252
is: B4DER4

metaR r0456
is version of: http://identifiers.org/ec-code/2.7.1.32
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is: SBO:0000176
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: false
is described by: ECO:0000000

metaM ump g
is: SBO:0000247
initial amount: NaN
is: HMDB00288
name: UMP(2-)
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
has only substance units: false
constant: false
boundary condition: false

metaR NTD11
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
name: 5'-nucleotidase (IMP)
is described by: ECO:0000269
reactant: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
product: MODEL1310110048#

metaM ha deg1 l
boundary condition: false
constant: false
type: Species
has only substance units: false
name: hyaluronan degradation product 1
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C22H33N2O16 CHARGE: -1
initial concentration: 1.0
is: CHEBI:16336

http://identifiers.org/biomodels.db/MODEL1310110048#_25f0e430_7db8_44d7_a450_5c4e0e2c7f55
initial amount: NaN
is encoded by: hsa:622
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: BDH1
boundary condition: true
type: Species

metaM duri e
type: Species
constant: false
name: Deoxyuridine
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
is: C00526
initial concentration: 1.0
is: HMDB00012
boundary condition: false
has only substance units: false
is: CHEBI:16450

http://identifiers.org/biomodels.db/MODEL1310110048#_5e8eedbd_3946_47b9_8c23_4c69cd41b725
initial concentration: NaN
constant: false
name: ACOT2
is: P49753
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10965

metaR H2O2t
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
name: hydrogen peroxide transport via diffusion
type: Reaction
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_98a98c30_44ea_49d8_8e71_d576e9f06301
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q8TE04
type: Species
initial concentration: NaN
name: PANK1
is encoded by: hsa:53354
boundary condition: true
constant: false

metaR r2128
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_4990e328_a5e9_4177_87ca_c7d4f6632d11
name: IDH1
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
is: O75874
is encoded by: hsa:3417
initial amount: NaN
initial concentration: NaN

metaR DIDPtn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dIDP nuclear transport
type: Reaction
reversible: true
reactant: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaR GTHP
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.9
name: glutathione peroxidase
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
reversible: true
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.11.1.12
fast: false
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_92ca07a1_13a2_4f91_bc38_695dbe97c3a5
initial amount: NaN
name: NME1
constant: false
is encoded by: hsa:4830
is: SBO:0000252
has only substance units: false
type: Species
is: P15531
initial concentration: NaN
boundary condition: true

metaR GALASE20ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
type: Reaction

metaM 2obut m
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: 2-oxobutanoate
is: CHEBI:16763
has only substance units: false
initial amount: NaN
is: HMDB00005
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109

metaM 3docopencoa m
has only substance units: false
is: SBO:0000247
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN
is: HMDB02288
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4

metaR LYStip
name: L-lysine transport, peroxisomal (irreversible)
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
product: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_335c4780_5089_4152_8cdb_11d1434d6415
initial amount: NaN
name: ATIC
type: Species
initial concentration: NaN
is encoded by: hsa:471
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P31939

metaR r2357
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110048#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_b5a5c7fd_4ec0_4914_bde4_2b0492731d51
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4725
initial amount: NaN
initial concentration: NaN
name: NDUFS5
is: SBO:0000252
is: Q6IBA0
has only substance units: false

metaR GTHO
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is described by: ECO:0000254
reversible: false
name: glutathione oxidoreductase
is: SBO:0000176
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#

metaR RE3079X
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3079
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
fast: false
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#
is: SBO:0000176

metaR RE1533M
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110048#
modifier: MODEL1310110048#
name: RE1533
kinetic law: MODEL1310110048#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true

metaR AG13T2g
type: Reaction
is: SBO:0000176
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110048#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false

metaR PA HSter
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
name: phosphatidate scramblase
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_d227abcb_1d56_4066_a22f_ff6ec40d2f5c
boundary condition: true
constant: false
is: Q9NY65
initial concentration: NaN
is encoded by: hsa:1962
name: EHHADH
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM thym c
initial concentration: 1.0
name: Thymine
is: C00178
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial amount: NaN
is: CHEBI:17821
is: SBO:0000247
type: Species
constant: false
is: HMDB00262
has only substance units: false

metaR RE3347C
reactant: MODEL1310110048#
name: RE3347
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
fast: false
product: MODEL1310110048#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_6d62e606_9464_49f8_acaf_94222b89969e
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51179
constant: false
has only substance units: false
is: Q9NYQ3
type: Species
name: HAO2
initial amount: NaN

metaR PSP L
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
name: phosphoserine phosphatase (L-serine)
is described by: ECO:0000269
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.3.3
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
reversible: false
reactant: MODEL1310110048#
is: SBO:0000176

metaM 3ddecdicoa m
has only substance units: false
is: C05280
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
type: Species
name: 3,6-dodecadienoylcoa
initial amount: NaN
boundary condition: false
is: HMDB03952
is: SBO:0000247

metaM ile L c
is: CHEBI:17191
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
constant: false
type: Species
is: HMDB00172
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: L-isoleucine

http://identifiers.org/biomodels.db/MODEL1310110048#_e1797f6f_75a3_4557_b78e_debd40257d04
has only substance units: false
is encoded by: hsa:53354
is: SBO:0000252
name: PANK1
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaM ksii core4 pre4 g
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
is: HMDB00175
type: Species
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 4
has only substance units: false
is: C00130
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

metaR AICARte
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
type: Reaction
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
is: SBO:0000185

metaR r1964
type: Reaction
modifier: MODEL1310110048#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false

metaR FAEL204
product: MODEL1310110048#
fast: false
name: fatty-acyl-CoA elongation (n-C20:4CoA)
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
kinetic law: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_3c2b0b2f_c347_48b8_a62c_09c1eae11e88
is: SBO:0000252
name: CHST5
initial amount: NaN
constant: false
boundary condition: true
is: Q9GZS9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23563
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_e368cdca_4e81_4f55_bc90_3f18eb025814
is: P51648
boundary condition: true
type: Species
is: SBO:0000252
name: ALDH3A2
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:224
has only substance units: false

metaR r1765
product: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport

metaM gacpail hs c
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00092
initial amount: NaN
is: CHEBI:61548
type: Species
initial concentration: 1.0
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01401

metaM gdp m
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: C00035
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58189
constant: false
name: GDP

http://identifiers.org/biomodels.db/MODEL1310110048#_a00ebf99_7744_4e47_a67b_be756484d209
boundary condition: true
is: Q16774
is: SBO:0000252
is encoded by: hsa:2987
name: GUK1
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM prist c
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00795
is: SBO:0000247
name: pristanic acid
type: Species
is: CHEBI:51340
boundary condition: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)

metaM akg c
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: 2-Oxoglutarate
is: C00026
is: CHEBI:16810
type: Species
has only substance units: false
is: HMDB00208

http://identifiers.org/biomodels.db/MODEL1310110048#_4ee55820_2d7c_4299_a984_c5a25273fcab
initial amount: NaN
name: PIGU
type: Species
is: SBO:0000252
boundary condition: true
is: Q9H490
has only substance units: false
constant: false
is encoded by: hsa:128869
initial concentration: NaN

metaR r1965
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_7c11cc04_af5e_4b50_b2b1_663c81b4283c
is encoded by: hsa:280
constant: false
is: P19961
type: Species
has only substance units: false
name: AMY2B
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR r2356
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_325ff6ae_0b1a_4139_bc4a_2fe21f51d747
name: PIGA
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:5277
boundary condition: true
initial concentration: NaN
type: Species
is: B3KUV7
is: SBO:0000252

metaR G14Tg
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110048#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110048#
reversible: false

metaR ADK1m
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
is: SBO:0000176
name: adenylate kinase, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_89347096_cf57_4c85_aea2_2f8a09167444
initial amount: NaN
is: P55851
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:7351
name: UCP2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_7c3ab277_52f1_4bc3_aef6_bc4f5a6026e8
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O43674
is encoded by: hsa:4711
constant: false
name: NDUFB5
boundary condition: true

metaR CYTDt
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
reversible: true
name: cytidine facilated transport in cytosol
is described by: ECO:0000269
product: MODEL1310110048#
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_cadd62b4_2072_4922_bcf6_94e021c3ef41
is: Q92685
initial concentration: NaN
initial amount: NaN
constant: false
name: ALG3
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10195
type: Species

metaR G13MT U
is described by: ECO:0000000
kinetic law: MODEL1310110048#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.132
modifier: MODEL1310110048#
product: MODEL1310110048#

metaR r1610
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaR MDHx
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
fast: false
reversible: true
name: malate dehydrogenase, peroxisomal
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176

metaM gdp n
boundary condition: false
type: Species
is: HMDB01201
constant: false
name: GDP(3-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189

metaM HC01410 m
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: CHEBI:28706
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA
initial amount: NaN
constant: false
is: SBO:0000247

metaR FAEL205
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is: SBO:0000176
type: Reaction
name: fatty-acyl-CoA elongation (n-C20:5CoA)
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaM fald c
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426
type: Species
is: CHEBI:16842
is: SBO:0000247
name: formaldehyde

metaR r2355
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185
product: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_bb59c4cd_fbc0_4929_ba60_2e38128feed8
initial amount: NaN
boundary condition: true
is: Q6NVC0
name: SLC25A5
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:292

metaR HMGCOASi
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110048#
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
modifier: MODEL1310110048#

metaM mal L m
initial amount: NaN
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15589
constant: false
boundary condition: false
has only substance units: false
name: (S)-malate(2-)
is: HMDB00156

metaM ppcoa m
boundary condition: false
is: SBO:0000247
type: Species
name: Propanoyl-CoA
has only substance units: false
constant: false
initial amount: NaN
is: C00100
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_68e0836e_8a5c_4a19_a2d6_dd054c299c75
initial concentration: NaN
boundary condition: true
is encoded by: hsa:28231
name: SLCO4A1
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: Q96BD0
is: SBO:0000252

metaM thym e
initial concentration: 1.0
has only substance units: false
name: thymine
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: SBO:0000247
constant: false
is: CHEBI:17821
type: Species
is: HMDB00262

metaR r0936
kinetic law: MODEL1310110048#
reversible: false
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaM bhb e
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:10983
type: Species
boundary condition: false
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011

metaM mlthf c
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
is: HMDB01533
boundary condition: false
is: C00143
is: SBO:0000247

metaR D LACt2
product: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
name: D-lactate transport via proton symport
is: SBO:0000185
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

metaM retinol c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
boundary condition: false
is: CHEBI:50211
name: retinol
constant: false
type: Species

metaM ile L e
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
is: HMDB00172
initial amount: NaN
is: CHEBI:17191
boundary condition: false
initial concentration: 1.0
name: L-isoleucine

metaM oxa x
type: Species
is: CHEBI:30623
constant: false
is: HMDB02329
name: oxalate(2-)
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM h2o2 x
constant: false
is: HMDB03125
is: CHEBI:16240
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Hydrogen peroxide
initial amount: NaN
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027

metaR r1611
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM dolmanp U r
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human uterine homolog
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:15809

metaM adrncoa c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: adrenyl coenzyme A

metaM CE5101 m
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57795
type: Species
is: SBO:0000247
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
boundary condition: false
initial concentration: 1.0

metaR r2354
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
reversible: true
reactant: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport

metaM akg e
type: Species
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
is: SBO:0000247
name: 2-oxoglutarate(2-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:16810
constant: false
is: HMDB00208

metaM dgsn c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: CHEBI:17172
is: C00330
name: Deoxyguanosine
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00085

metaM gcald c
name: glycolaldehyde
is: SBO:0000247
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB03344
has only substance units: false
initial amount: NaN
is: CHEBI:17071

http://identifiers.org/biomodels.db/MODEL1310110048#_3297cb50_71b8_46bd_9520_0b0e04437226
initial concentration: NaN
name: PAPSS1
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: O43252
is encoded by: hsa:9061

http://identifiers.org/biomodels.db/MODEL1310110048#_f499475c_0aaf_4829_806f_a00636db1309
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:160851
boundary condition: true
name: DGKH
constant: false
is: SBO:0000252
is: A8K0I1
initial concentration: NaN

metaR GGH 6THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6THF), extracellular

http://identifiers.org/biomodels.db/MODEL1310110048#_fb612e21_c746_4176_9c1d_361aff9ba63b
is: P22234
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10606
has only substance units: false
constant: false
name: PAICS

metaR r0937
reversible: true
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
name: Transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110048#

metaR C226CRNt
product: MODEL1310110048#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
name: C226 transport into the mitochondria
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110048#_d0442c68_cd95_4512_91cb_10eae83a9b27
constant: false
is: SBO:0000252
name: SLC6A2
is: Q96KH8
type: Species
initial concentration: NaN
is encoded by: hsa:6530
has only substance units: false
boundary condition: true
initial amount: NaN

metaR HDCAtr
reactant: MODEL1310110048#
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_7b98de69_1bc0_4797_956b_d8d06ab5a0ff
has only substance units: false
initial concentration: NaN
constant: false
name: ATG9B
initial amount: NaN
is: Q674R7
is encoded by: hsa:285973
is: SBO:0000252
type: Species
boundary condition: true

metaR DHCR71r
modifier: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
product: MODEL1310110048#
type: Reaction
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110048#
is described by: ECO:0000134

metaR r1612
kinetic law: MODEL1310110048#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110048#
reversible: true
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dcmp c
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: C00239
constant: false
is: SBO:0000247
is: HMDB01202
is: CHEBI:57566
type: Species
name: dCMP
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_0208de91_bbbf_4602_8659_042f19c0640a
type: Species
name: SLC4A2
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6522
has only substance units: false
is: F8W682
initial concentration: NaN
initial amount: NaN

metaR THP2Ctp
kinetic law: MODEL1310110048#
fast: false
reversible: true
type: Reaction
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_ab525ed9_9ecf_4977_b47b_7ca4278b66a8
initial amount: NaN
boundary condition: true
name: PCBD1
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5092
is: SBO:0000252

metaM akg m
initial amount: NaN
boundary condition: false
is: CHEBI:16810
has only substance units: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
initial concentration: 1.0
is: C00026
name: 2-Oxoglutarate
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_568bda5a_c660_4ecf_a397_b6e81a0f2d6f
is: SBO:0000252
is encoded by: hsa:2224
constant: false
initial concentration: NaN
has only substance units: false
name: FDPS
type: Species
initial amount: NaN
boundary condition: true
is: P14324

http://identifiers.org/biomodels.db/MODEL1310110048#_37ccd8e7_fd13_49fb_b5af_cf4c6cf924f6
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10935
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: E9PH29
name: PRDX3

metaR PROSTGI2tr
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110048#
is: SBO:0000185
name: Prostaglandin I2 transport (ER)
reversible: true
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

metaM h r
is: C00080
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: SBO:0000247
initial amount: NaN
name: proton
constant: false
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110048#_4a109dfe_a757_46d8_a157_5693ed8f8615
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: PIP5K1C
is: O60331
boundary condition: true
is encoded by: hsa:23396
initial amount: NaN
type: Species

metaR PSSA1 hs
product: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is: SBO:0000176
reactant: MODEL1310110048#
name: Phosphatidylserine synthase homo sapiens
reversible: true
fast: false
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.29

metaR r1556
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110048#
product: MODEL1310110048#

metaM co2 m
is: C00011
is: HMDB01967
name: CO2
initial amount: NaN
constant: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM ddcacoa x
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB03571
type: Species
initial concentration: 1.0
is: CHEBI:57375
boundary condition: false
has only substance units: false
is: C01832

metaR URIDK2m
kinetic law: MODEL1310110048#
name: uridylate kinase (dUMP), mitochondrial
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
is described by: ECO:0000134
product: MODEL1310110048#
is: SBO:0000176
reversible: true
type: Reaction

metaR r1661
kinetic law: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
reactant: MODEL1310110048#

metaM coa m
name: Coenzyme A
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01423
initial concentration: 1.0
is: CHEBI:57287
is: C00010
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR FACOAL160i
is described by: ECO:0000269
reactant: MODEL1310110048#
reversible: false
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
name: C160 fatty acid activation
is: SBO:0000176
modifier: MODEL1310110048#
type: Reaction

metaM thym m
is: CHEBI:17821
boundary condition: false
type: Species
has only substance units: false
name: thymine
constant: false
initial amount: NaN
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: SBO:0000247
is: HMDB00262
initial concentration: 1.0

metaM cytd e
constant: false
has only substance units: false
type: Species
name: Cytidine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
is: HMDB00089
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_ecd0b884_ac9e_4ee4_8e08_15988aeabff8
type: Species
constant: false
initial amount: NaN
name: HADH
is encoded by: hsa:3033
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q16836
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_9bfe949b_c594_4d06_8bd0_195b2eb73bdc
is encoded by: hsa:81539
type: Species
constant: false
initial concentration: NaN
name: SLC38A1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9H2H9
boundary condition: true

metaR LNLCCPT2
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
modifier: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110048#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_fe2fa71e_5d1c_44cb_acef_de843d21a44f
constant: false
is: P32321
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: DCTD
is encoded by: hsa:1635
initial concentration: NaN
has only substance units: false

metaR r0997
product: MODEL1310110048#
is described by: ECO:0000000
name: COT Facilitated diffusion
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM hdca e
is: C00249
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1
initial amount: NaN
is: SBO:0000247
is: CHEBI:0
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Hexadecanoate (n-C16:0)
constant: false

metaR THRASNNaEx
type: Reaction
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000269

metaR ORNt3m
name: ornithine mitochondrial transport via proton antiport
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#

metaR VLCS2r
reversible: false
modifier: MODEL1310110048#
is described by: ECO:0000304
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
type: Reaction
reactant: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM estradiol r
name: estradiol
type: Species
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00151
is: CHEBI:16469
is: SBO:0000247
initial amount: NaN

metaR r0784
type: Reaction
is: SBO:0000176
reactant: MODEL1310110048#
fast: false
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000

metaR r0842
modifier: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110048#
name: Postulated transport reaction
reversible: true
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
fast: false
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000185

metaR r1557
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110048#
fast: false
reversible: true
is: SBO:0000185

metaM cmp n
constant: false
initial concentration: 1.0
is: CHEBI:60377
is: HMDB00095
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
boundary condition: false
name: CMP(2-)
initial amount: NaN

metaR MANtg
fast: false
reactant: MODEL1310110048#
name: mannose efflux from Golgi apparatus
reversible: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR GLNTHRNaEx
reversible: false
modifier: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110048#

metaR GDPFUCtg
is described by: ECO:0000269
reversible: true
product: MODEL1310110048#
name: GDPFuc Golgi transport via CMP antiport
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
kinetic law: MODEL1310110048#
fast: false

metaR r1662
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
modifier: MODEL1310110048#

metaM coa n
name: coenzyme A(4-)
is: HMDB01423
constant: false
boundary condition: false
is: CHEBI:57287
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_c875b785_b461_4097_9ad3_62d64f9b0a70
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: _2544_1_c
is encoded by: hsa:2544
has only substance units: false

metaM CE0713 m
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:30623
is: HMDB02329
name: 3-oxolinoleoyl-CoA
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false

metaM 3mop e
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:28654
type: Species
is: HMDB00491
has only substance units: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1

metaM man1p c
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial amount: NaN
name: D-Mannose 1-phosphate
is: CHEBI:35374
boundary condition: false
type: Species
constant: false
is: HMDB06330
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9376a879_55a8_481f_86b0_11ebe38be900
is encoded by: hsa:767
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: CA8
is: P35219
has only substance units: false

metaR r0998
is: SBO:0000185
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
name: Facilitated diffusion
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM ksi pre19 g
name: keratan sulfate I biosynthesis, precursor 19
is: C00130
boundary condition: false
is: SBO:0000247
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00175
constant: false
is: CHEBI:58053
type: Species

metaM dump m
has only substance units: false
is: CHEBI:246422
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
is: HMDB01409
is: SBO:0000247
name: dUMP(2-)
initial amount: NaN

metaM gdpmann c
initial concentration: 1.0
is: HMDB01163
constant: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial amount: NaN
has only substance units: false
boundary condition: false
name: GDP-alpha-D-mannose(2-)
is: CHEBI:57527
is: SBO:0000247
type: Species

metaR LEUTA
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
name: leucine transaminase
modifier: MODEL1310110048#
fast: false
product: MODEL1310110048#
is described by: ECO:0000269
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110048#

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM arg L c
is: HMDB00517
name: L-argininium(1+)
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
is: CHEBI:32682
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_2b4e2252_7e5c_448d_9492_d32aec8ad645
has part: P13804
is encoded by: hsa:2108
is encoded by: hsa:2109
name: ETFA:ETFB
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_21473f1b_103f_4b92_a2cf_4087ff9a989a
initial concentration: NaN
is: O60762
is encoded by: hsa:8813
has only substance units: false
type: Species
name: DPM1
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_843ff178_7be0_4368_a296_2f93895ef00f
boundary condition: true
has only substance units: false
name: DDO
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8528
is: Q99489

metaM cytd c
is: C00475
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
name: Cytidine
is: CHEBI:17562
is: HMDB00089
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR r0783
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
fast: false
reactant: MODEL1310110048#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
product: MODEL1310110048#

metaM fgam c
initial amount: NaN
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: SBO:0000247
is: CHEBI:58426
initial concentration: 1.0
has only substance units: false
is: C04376
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
constant: false
boundary condition: false
type: Species
is: HMDB01308

metaM 2octdectecoa m
constant: false
name: 2,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB02288
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
type: Species

metaM retfa c
is: CHEBI:50211
initial concentration: 1.0
is: HMDB00305
initial amount: NaN
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
constant: false
type: Species
has only substance units: false
boundary condition: false
name: fatty acid retinol
is: SBO:0000247

metaR RE3626M
product: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
is: SBO:0000176
name: RE3626
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR ACGAMK
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
fast: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.59
name: N-acetylglucosamine kinase

http://identifiers.org/biomodels.db/MODEL1310110048#_5b3a93a5_77eb_43f3_bf4f_c57f90b79a10
type: Species
is: SBO:0000252
name: AKR1A1
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:10327

metaR r0999
kinetic law: MODEL1310110048#
product: MODEL1310110048#
name: Facilitated diffusion
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true

metaR HYXNt
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reversible: true
product: MODEL1310110048#
is described by: ECO:0000269
name: Hypoxanthine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reactant: MODEL1310110048#

metaR C3STKR2r
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000134
reversible: false
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
name: C-3 sterol keto reductase (zymosterol)
is: SBO:0000176
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaR CYTK8n
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: true
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dATP),nuclear

metaM dhcholestanate r
constant: false
has only substance units: false
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
is: HMDB00359
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaM dhcholestancoa x
initial concentration: 1.0
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB02159
type: Species
is: SBO:0000247
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
constant: false

metaR PI45P5P
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110048#
type: Reaction
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reactant: MODEL1310110048#
reversible: false

metaM hdca c
type: Species
is: SBO:0000247
is: HMDB00220
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate
is: CHEBI:7896
boundary condition: false
has only substance units: false

metaR r1559
is described by: ECO:0000000
reversible: true
product: MODEL1310110048#
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
fast: false

metaR r0208
is version of: http://identifiers.org/ec-code/4.4.1.1
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
fast: false
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
modifier: MODEL1310110048#
reversible: true
is: SBO:0000176
product: MODEL1310110048#
is described by: ECO:0000000
type: Reaction

metaM CE2705 c
initial amount: NaN
constant: false
is: CHEBI:36781
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
type: Species
boundary condition: false
name: quinonoid dihydrobiopterin
has only substance units: false

metaR CAATPS
product: MODEL1310110048#
modifier: MODEL1310110048#
name: Ca ATPase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.8
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
kinetic law: MODEL1310110048#

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
product: MODEL1310110048#
fast: false
name: PTPATe
type: Reaction
is: SBO:0000176
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110048#_affbd038_5170_451c_9c04_89096fa16e6a
initial concentration: NaN
is: O95258
is encoded by: hsa:9016
name: SLC25A14
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_ea37f471_19c8_493c_9463_580313467e46
name: GCNT1
is: SBO:0000252
constant: false
is encoded by: hsa:2650
is: Q02742
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaR r0782
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
type: Reaction
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
reversible: false
product: MODEL1310110048#

metaR r1664
type: Reaction
reversible: true
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#

metaR CLPNDCOAtx
reactant: MODEL1310110048#
name: fatty acid intracellular transport
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_53dba6d8_d9c5_42ee_8d40_d8a05954394e
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:8802
is: P53597
name: SUCLG1
initial concentration: NaN
type: Species

metaM nrpphr e
is: CHEBI:33569
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
is: HMDB00216
boundary condition: false

metaR DMATTx
is described by: ECO:0000134
kinetic law: MODEL1310110048#
name: dimethylallyltranstransferase
reversible: false
modifier: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
fast: false
is: SBO:0000176

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r2358
reactant: MODEL1310110048#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110048#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_b821ae8d_dcc0_4769_9f49_e82493a5271f
is encoded by: hsa:9245
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: O95395
boundary condition: true
name: GCNT3
constant: false
has only substance units: false

metaR r0917
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110048#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaR r0789
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
is: SBO:0000176
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110048#

metaR S23T3g
modifier: MODEL1310110048#
reversible: false
product: MODEL1310110048#
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.6
reactant: MODEL1310110048#

metaR MMCDm
fast: false
product: MODEL1310110048#
is described by: ECO:0000212
name: Methylmalonyl-CoA decarboxylase, mitochondrial
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
is: SBO:0000176
modifier: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.1.1.9

metaM asn L c
is: HMDB00168
type: Species
boundary condition: false
is: CHEBI:17196
initial amount: NaN
is: SBO:0000247
name: L-asparagine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ae33c1da_ad13_492e_aa9c_415cc1b4f3d1
is encoded by: hsa:10201
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: O75414
boundary condition: true
name: NME6
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_c863cbab_9e81_4bfe_b9c4_a4b93d5eb604
constant: false
type: Species
is: Q6LEN6
is encoded by: hsa:1103
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: CHAT
initial amount: NaN

metaM tddedi2coa m
boundary condition: false
type: Species
has only substance units: false
is: C08277
is: HMDB00792
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: trans2,6dodecadienoylcoa
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110048#_7741f59c_faa0_4c61_b0a6_8fdd8cda3e91
name: PRDX1
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:5052
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_b589c165_b6ce_490e_b5a7_964bd138a526
constant: false
has only substance units: false
is: B8ZZR8
boundary condition: true
is encoded by: hsa:79017
initial concentration: NaN
type: Species
name: GGCT
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_e372247b_73c3_45fb_9f70_e7fb27f3d837
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:34
boundary condition: true
name: ACADM
type: Species
is: P11310

http://identifiers.org/biomodels.db/MODEL1310110048#_24487d75_3e03_4c4f_830b_7f37e6166489
boundary condition: true
is encoded by: hsa:3948
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: LDHC
is: SBO:0000252
has only substance units: false
is: P07864

metaR r0560
fast: false
product: MODEL1310110048#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
type: Reaction
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is: SBO:0000176
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_5a8ca0fd_9abb_4f93_8830_9ac0bbe0918b
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: Q9H2B4
name: SLC26A1
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10861

metaR HSD3B3r
type: Reaction
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110048#
name: 3 beta-hydroxysteroid dehydrogenase type 1
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11384872,PMID:14643063 NOTES:see PMID: 14643063 specific cofactors/etc have not yet been determined - largely inferred NJ
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110048#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_5a5c4582_528d_4d4d_bc55_528d0c070adf
type: Species
name: LSS
is: E9PEI9
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4047

http://identifiers.org/biomodels.db/MODEL1310110048#_c50ef6d6_0e05_4709_9a14_728a5d612b1b
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:215
is: P33897
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ABCD1

http://identifiers.org/biomodels.db/MODEL1310110048#_170eb5da_c90f_45ec_98db_acaf8f7103f8
is encoded by: hsa:4594
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: P22033
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: MUT

metaM pectintchol e
name: pectin-taurocholic acid complex
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03402
boundary condition: false
initial amount: NaN
notes: FORMULA: C2561H3555NO2542S CHARGE: 0

metaR r2359
fast: false
product: MODEL1310110048#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110048#
is described by: ECO:0000000
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaR r0788
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaM dhcholestanate x
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
type: Species
initial concentration: 1.0
is: HMDB00359
is: SBO:0000247
boundary condition: false
is: CHEBI:16577
has only substance units: false
initial amount: NaN

metaR LEUKTRA4t
is described by: ECO:0000269
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
name: leukotriene A4 transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_72fcb4e2_0569_4a8e_bc4f_f46b867d683c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:57171
initial amount: NaN
constant: false
is: Q86YN1
name: DOLPP1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110048#_a55b9160_4519_4679_87fb_811cc5f16651
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NDUFA6
type: Species
initial concentration: NaN
is: P56556
constant: false
has only substance units: false
is encoded by: hsa:4700

http://identifiers.org/biomodels.db/MODEL1310110048#_61583143_5f5f_4ec5_9638_d3d72d7a40ba
name: CA5B
type: Species
is: Q9Y2D0
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:11238
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110048#_7e5e29fe_40fd_4729_860e_5c36964f255d
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q8N4A0
name: GALNT4
constant: false
is: SBO:0000252
is encoded by: hsa:8693
initial amount: NaN
type: Species

metaR AIRCr
is: SBO:0000176
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110048#
name: phosphoribosylaminoimidazole carboxylase
reversible: true
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/6.3.2.6
is described by: ECO:0000269
product: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction

metaM q10h2 e
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB13111
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
constant: false
initial concentration: 1.0
name: Ubiquinol-10
initial amount: NaN

metaM 1pyr5c m
initial concentration: 1.0
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
constant: false
type: Species
is: CHEBI:15893
is: HMDB01301
has only substance units: false
boundary condition: false
is: C03912
initial amount: NaN
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247

metaM coa r
is: C00010
initial amount: NaN
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
boundary condition: false
name: Coenzyme A
is: CHEBI:57287
constant: false
type: Species
initial concentration: 1.0
is: HMDB01423

metaM crvnc e
constant: false
name: cervonic acid, C22:6 n-3
has only substance units: false
type: Species
notes: FORMULA: C22H31O2 CHARGE: -1
is: CHEBI:36005
is: HMDB02183
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR DPMVDc
is described by: ECO:0000134
name: diphosphomevalonate decarboxylase, cytosol
product: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.33
fast: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is: SBO:0000176
reversible: false

metaM asn L e
type: Species
name: L-asparagine
is: SBO:0000247
is: CHEBI:17196
initial amount: NaN
is: HMDB00168
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

http://identifiers.org/biomodels.db/MODEL1310110048#_9da0653f_1e53_4c42_bc9f_e8bed1de44e2
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:3945
constant: false
name: LDHB
is: P07195

metaR r0202
is: SBO:0000176
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
is described by: ECO:0000000
reversible: true
product: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false

metaR ABUTD
reversible: false
kinetic law: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110048#
name: Aminobutyraldehyde dehydrogenase
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
is described by: ECO:0000269

metaR VLCSp
modifier: MODEL1310110048#
name: Very-long-chain-fatty-acid-CoA ligase
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
type: Reaction

metaR RE1573M
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
product: MODEL1310110048#
name: RE1573
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_1e90de93_9aa0_4c2e_9c55_3c13c4645232
type: Species
initial amount: NaN
has only substance units: false
is: Q96FL9
constant: false
name: GALNT14
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79623
boundary condition: true

metaR PPA
fast: false
name: inorganic diphosphatase
kinetic law: MODEL1310110048#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
reversible: false
modifier: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110048#

metaM ethamp c
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00224
type: Species
name: ethamp[c]
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false
is: CHEBI:58190
constant: false
initial concentration: 1.0

metaR r1318
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185
type: Reaction
fast: false

metaR LNLCCPT1
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
product: MODEL1310110048#
type: Reaction

metaR 3MOBte
is described by: ECO:0000134
product: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110048#
reversible: true
name: Transport of 3-methyl-2-oxobutanoate
kinetic law: MODEL1310110048#

metaM 4fumacac c
is: SBO:0000247
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
type: Species
has only substance units: false
constant: false
is: CHEBI:18034
name: 4-fumarylacetoacetate(2-)
initial amount: NaN
boundary condition: false
is: HMDB01268
initial concentration: 1.0

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_c53f6546_a789_44f4_b1fd_3ab8a7e69993
name: SLC2A13
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:114134
constant: false
boundary condition: true
is: Q96QE2
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_0233bf99_605b_4d0b_8eb4_2115ac7d71b6
initial amount: NaN
boundary condition: true
name: PANK1
constant: false
initial concentration: NaN
is encoded by: hsa:53354
has only substance units: false
is: SBO:0000252
type: Species

metaR r1292
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110048#
fast: false
is: SBO:0000185
product: MODEL1310110048#
type: Reaction

metaM cmp g
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
name: CMP(2-)
is: CHEBI:60377
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00095

metaM ha e
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
is: CHEBI:16336
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: hyaluronan

metaR r0787
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
product: MODEL1310110048#
is: SBO:0000176
modifier: MODEL1310110048#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110048#
fast: false

metaM ptrc e
has only substance units: false
type: Species
constant: false
is: HMDB01414
boundary condition: false
is: CHEBI:326268
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine
initial concentration: 1.0
is: C00134

metaR GPIAT
type: Reaction
reactant: MODEL1310110048#
is described by: ECO:0000269
name: glucosaminylphosphatidyl inositol acetyltransferase
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
product: MODEL1310110048#
is: SBO:0000176
reversible: false
modifier: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#

metaR r0179
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
type: Reaction
reactant: MODEL1310110048#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is described by: ECO:0000000
reversible: true

metaM malthp e
name: maltoheptaose
constant: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: C01936
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837

metaR THYOXt2
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110048#
name: T4 transport via facilitated diffusion
kinetic law: MODEL1310110048#
is: SBO:0000185

metaM prostgi2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403
constant: false
is: HMDB01335
is: SBO:0000247
name: prostaglandin I2(1-)
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN

metaR DESAT22 1p
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reactant: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
type: Reaction

metaM glygn5 e
type: Species
constant: false
is: HMDB06372
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:33871
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H21O11X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110048#_bf01947e_b8d2_4e53_a45b_b3f835790b83
boundary condition: true
type: Species
name: ACO1
has only substance units: false
constant: false
is encoded by: hsa:48
is: SBO:0000252
initial amount: NaN
is: P21399
initial concentration: NaN

metaR VLCS2p
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
modifier: MODEL1310110048#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110048#
reversible: false
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110048#
reactant: MODEL1310110048#
name: Very-long-chain-fatty-acid-CoA ligase

metaR HPYRR2x
kinetic law: MODEL1310110048#
is: SBO:0000176
reversible: false
name: hydroxypyruvate reductase (NADH)
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.27

metaM ksi pre16 g
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: HMDB00175
is: CHEBI:58053
is: C00130
type: Species
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 16
has only substance units: false
initial amount: NaN

metaM omhdecacid c
name: w-hydroxydecanoicacid
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H19O3 CHARGE: -1
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01022

http://identifiers.org/biomodels.db/MODEL1310110048#_a9ba025a_8cbd_4da0_955f_f30a7b4bc834
initial amount: NaN
has part: Q9BRB3
boundary condition: true
is encoded by: hsa:9091
has part: B3KUV7
is encoded by: hsa:51227
constant: false
is encoded by: hsa:5279
type: Species
initial concentration: NaN
has part: O94777
is encoded by: hsa:8818
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5277
is encoded by: hsa:5283
is: SBO:0000297
has part: Q14442
has only substance units: false
has part: Q92535

metaR CORE3GTg
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110048#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
type: Reaction
fast: false

metaR PIPLC
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol phospholipase C
is: SBO:0000176
kinetic law: MODEL1310110048#

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR UGT1A10r
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reactant: MODEL1310110048#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
modifier: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true

metaM succ c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00042
has only substance units: false
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
constant: false
type: Species
is: CHEBI:30031
is: SBO:0000247

metaM crvnc c
constant: false
initial amount: NaN
type: Species
name: cervonic acid, C22:6 n-3
boundary condition: false
notes: FORMULA: C22H31O2 CHARGE: -1
is: SBO:0000247
has only substance units: false
is: CHEBI:36005
initial concentration: 1.0
is: HMDB02183

metaM q10h2 c
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
name: Ubiquinol-10
constant: false
initial amount: NaN

metaM memgacpail hs r
constant: false
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
has only substance units: false
is: CHEBI:15809
initial concentration: 1.0

metaM 3mop c
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
constant: false
is: CHEBI:28654
type: Species
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
initial amount: NaN
is: HMDB00491
boundary condition: false

metaR r1660
modifier: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110048#
reversible: true
product: MODEL1310110048#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110048#

metaR r1291
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110048#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110048#
reversible: true
name: Postulated transport reaction
kinetic law: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_8790ee1b_aa0c_4f33_bd41_1e23b7aa28a1
is encoded by: hsa:4967
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: OGDH
is: SBO:0000252
boundary condition: true
is: Q02218

http://identifiers.org/biomodels.db/MODEL1310110048#_7dfb50e9_44e7_4aef_9291_259975a7e5e4
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _D29675_1_e
is encoded by: hsa:D29675
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ae85ee63_9304_4ec1_82dd_64e5fd71bc4d
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: P27986
name: PIK3R1
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5295

metaR r0178
modifier: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
type: Reaction
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.21
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110048#_a2dd82c8_54af_4dfa_a9c5_9813b8837888
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: B3GNT6
is encoded by: hsa:192134
constant: false
is: A8K9Q8

http://identifiers.org/biomodels.db/MODEL1310110048#_983f07e4_d3b5_4a26_b3fb_346be4c500d9
is: Q9UHI7
is encoded by: hsa:9963
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: SLC23A1
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM dcyt e
is: HMDB00014
initial amount: NaN
is: C00881
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
is: CHEBI:15698
boundary condition: false
name: Deoxycytidine

http://identifiers.org/biomodels.db/MODEL1310110048#_503a9cd6_96d7_43d7_afc3_b52d3e16a26b
boundary condition: true
type: Species
is encoded by: hsa:AI656480
name: _AI656480_1_m
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r0068
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.1
is described by: ECO:0000000
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1

metaM 7thf e
name: heptaglutamyl folate (THF)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
constant: false
is: HMDB06559
type: Species
is: SBO:0000247

metaR G14T2g
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
type: Reaction

metaR SPH1Pte
type: Reaction
is described by: ECO:0000000
product: MODEL1310110048#
fast: false
reversible: true
reactant: MODEL1310110048#
name: sph1p transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
kinetic law: MODEL1310110048#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_8b3008ef_9e36_4996_a02c_147745260cde
boundary condition: true
type: Species
name: RENBP
has only substance units: false
is encoded by: hsa:5973
initial amount: NaN
initial concentration: NaN
is: P51606
is: SBO:0000252
constant: false

metaR S6T6g
kinetic law: MODEL1310110048#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
modifier: MODEL1310110048#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR ADCim
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
is: SBO:0000176
reversible: false
product: MODEL1310110048#
fast: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is described by: ECO:0000000
type: Reaction

metaR UMPK4
is described by: ECO:0000269
product: MODEL1310110048#
fast: false
reversible: true
name: UMP kinase (GTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
type: Reaction

metaM ura e
type: Species
has only substance units: false
is: SBO:0000247
name: uracil
boundary condition: false
is: CHEBI:17568
initial concentration: 1.0
constant: false
is: HMDB00300
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial amount: NaN

metaR LGTHL
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
modifier: MODEL1310110048#
name: lactoylglutathione lyase
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
fast: false
is version of: http://identifiers.org/ec-code/4.4.1.5
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110048#_acc54ca1_9bbb_40b2_91bb_c3db4d368d4f
type: Species
is: Q02221
has only substance units: false
initial concentration: NaN
name: COX6A2
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1339

metaR r2084
type: Reaction
modifier: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR PIt8
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is described by: ECO:0000006
is: SBO:0000185
fast: false
name: phosphate transport in/out via Na+ symporter
reactant: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#

metaM CE5586 c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
type: Species
initial amount: NaN
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
has only substance units: false
constant: false
is: CHEBI:58732

metaR FTCD
kinetic law: MODEL1310110048#
fast: false
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.1.2.5
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
name: formimidoyltransferase cyclodeaminase
is: SBO:0000176
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction

metaM HC01603 c
is: C00234
has only substance units: false
initial concentration: 1.0
type: Species
name: 10-Formyltetrahydrofolate
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false

metaR r2140
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110048#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110048#
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM zymst r
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: zymosterol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial amount: NaN
is: CHEBI:18252
has only substance units: false
constant: false
is: HMDB06271

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
initial amount: NaN
type: Species
boundary condition: false
name: trans-3-decenoyl-CoA
is: CHEBI:57449
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9a66b2e1_f85f_4efe_b279_8b5697ea7702
boundary condition: true
is: Q14435
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: GALNT3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2591

http://identifiers.org/biomodels.db/MODEL1310110048#_70262c48_f67a_41e8_8efd_28c5a9822e2f
has only substance units: false
name: _H53099_1_m
is: SBO:0000252
is encoded by: hsa:H53099
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaM urcan c
type: Species
has only substance units: false
name: Urocanate
is: HMDB00301
is: SBO:0000247
is: CHEBI:17771
is: C00785
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR r1669
is described by: ECO:0000000
reversible: true
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false

metaR r2201
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction

metaM dump c
boundary condition: false
is: C00365
has only substance units: false
is: HMDB01409
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:246422
type: Species
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP

http://identifiers.org/biomodels.db/MODEL1310110048#_888725ed_f975_46de_a75a_fc7e8c876008
type: Species
boundary condition: true
is encoded by: hsa:374291
initial concentration: NaN
name: NDUFS7
has only substance units: false
initial amount: NaN
is: O75251
constant: false
is: SBO:0000252

metaR PPCDC
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
name: phosphopantothenoylcysteine decarboxylase
modifier: MODEL1310110048#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
reversible: false
is: SBO:0000176

metaR PROSTGD2t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
reversible: true
reactant: MODEL1310110048#
product: MODEL1310110048#
is described by: ECO:0000269
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#

metaM CE2705 n
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: quinonoid dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
type: Species
is: HMDB02281
initial amount: NaN
is: SBO:0000247
is: CHEBI:15374
constant: false

metaR GLNtm
is: SBO:0000185
product: MODEL1310110048#
fast: false
reversible: false
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reactant: MODEL1310110048#
name: L-glutamine transport via electroneutral transporter
is described by: ECO:0000000

metaR LTC4CP
kinetic law: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is described by: ECO:0000000
is: SBO:0000176
name: Leukotriene C4 carboxypeptidase
product: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6f6d7a95_b4ab_4a9c_ab4d_e36ef46e8138
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: HK1
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3098
is: A8K7J7

metaR DM anth
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_78e977f7_77e9_491c_bc8e_87debab6268d
name: _W74642_1_c
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:W74642
constant: false
has only substance units: false

metaM glypro e
initial amount: NaN
is: http://identifiers.org/pubchem.compound/79101
is: SBO:0000247
is: HMDB00721
notes: FORMULA: C7H12N2O3 CHARGE: 0
name: Glycylproline
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species

metaR UMPK5
reactant: MODEL1310110048#
is described by: ECO:0000269
modifier: MODEL1310110048#
product: MODEL1310110048#
fast: false
name: UMP kinase (dATP)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110048#

metaM pail45p hs m
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
initial amount: NaN
is: CHEBI:28910
initial concentration: 1.0
constant: false

metaR r2083
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
reactant: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
product: MODEL1310110048#

metaR FAOXC225C226m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR PIt7
fast: false
reversible: true
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
modifier: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110048#_fb11fba2_82d8_4b7f_9412_4dc5d06bbea9
boundary condition: true
type: Species
is encoded by: hsa:7355
has only substance units: false
constant: false
initial concentration: NaN
name: SLC35A2
is: SBO:0000252
initial amount: NaN
is: P78381

metaR r2141
fast: false
reversible: true
reactant: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110048#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110048#

metaM chol n
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline
is: HMDB00097
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:15354
initial concentration: 1.0
constant: false
boundary condition: false

metaR GLUDxm
fast: false
is described by: ECO:0000269
reactant: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
product: MODEL1310110048#
name: glutamate dehydrogenase (NAD) (mitochondrial)
reversible: true
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.1.3

metaM ha l
constant: false
initial concentration: 1.0
name: hyaluronan
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species
has only substance units: false
is: CHEBI:16336
is: SBO:0000247
boundary condition: false

metaM dhcholestancoa r
constant: false
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
boundary condition: false
is: SBO:0000247
is: CHEBI:15494
initial concentration: 1.0
is: HMDB02159
initial amount: NaN
has only substance units: false

metaM cmp e
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
is: HMDB00095
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: CMP(2-)
boundary condition: false
type: Species
has only substance units: false

metaM co2 e
is: HMDB01967
is: SBO:0000247
constant: false
initial amount: NaN
name: CO2
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011

http://identifiers.org/biomodels.db/MODEL1310110048#_98403db0_7098_40b7_b154_bd0d737896cf
has only substance units: false
boundary condition: true
name: PKM2
type: Species
constant: false
is: B4DNK4
initial concentration: NaN
is encoded by: hsa:5315
is: SBO:0000252
initial amount: NaN

metaR r2202
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
modifier: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110048#_d4167f7e_4e7d_4f70_b8b6_e2360d791644
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:2639
is: Q92947
name: GCDH
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_42c4d79e_1b2b_407e_b22c_d9ef0c212a68
is: SBO:0000252
name: NT5C1B
is encoded by: hsa:93034
boundary condition: true
constant: false
has only substance units: false
is: B3KUK6
initial amount: NaN
type: Species
initial concentration: NaN

metaR PGDI
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.3.99.2
name: Prostaglandin-H2 D-isomerase [Precursor]
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.5.1.18

http://identifiers.org/biomodels.db/MODEL1310110048#_314ef0ac_e413_4e5c_a143_8279731117a8
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: CTPS2
type: Species
is encoded by: hsa:56474
constant: false
is: Q9NRF8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_8aaa342a_2f3e_428d_93cb_3b187f478e63
is encoded by: hsa:80704
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: SLC19A3
is: Q9BZV2
constant: false
has only substance units: false

metaM hdca l
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00220
type: Species
name: palmitate
initial concentration: 1.0
constant: false
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM dcyt c
boundary condition: false
initial amount: NaN
is: CHEBI:15698
initial concentration: 1.0
constant: false
name: Deoxycytidine
is: SBO:0000247
has only substance units: false
is: C00881
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR FAOXC16C14m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_304e2a57_ad7b_4293_a6ec_82a3250e56d1
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: DGKI
is: O75912
has only substance units: false
is encoded by: hsa:9162
initial concentration: NaN
type: Species

metaM ksii core2 deg5 l
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 5
is: SBO:0000247
boundary condition: false
is: HMDB00143
is: CHEBI:12936
constant: false
initial amount: NaN
has only substance units: false

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
constant: false
type: Species
boundary condition: false
is: CHEBI:28910
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

http://identifiers.org/biomodels.db/MODEL1310110048#_a6516fe9_4c00_44f5_a1f7_0c713c6bdae6
constant: false
type: Species
boundary condition: true
name: ACOX1
is: Q15067
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51
is: SBO:0000252

metaR UMPK6
fast: false
product: MODEL1310110048#
reversible: true
name: UMP kinase (dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000269

metaR RE1903R
reactant: MODEL1310110048#
name: RE1903
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is described by: ECO:0000000
type: Reaction

metaR S6T16g
reversible: false
kinetic law: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
product: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110048#_301ae364_6c0d_49a3_9c19_9a72be30c6ae
type: Species
constant: false
is: Q5T4Y1
is: SBO:0000252
boundary condition: true
name: ST3GAL3
has only substance units: false
is encoded by: hsa:6487
initial concentration: NaN
initial amount: NaN

metaR r2142
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110048#

metaR r2086
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
kinetic law: MODEL1310110048#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110048#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_1569a3c1_809b_42b7_b1cf_ce5bb3c9edab
type: Species
is: B7Z7I0
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8277
name: TKTL1
boundary condition: true

metaM o2 e
is: CHEBI:15379
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
is: HMDB01377
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: C00007
name: O2

metaR DASCBR
modifier: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
name: dehydroascorbate reductase
is version of: http://identifiers.org/ec-code/1.8.4.1
is described by: ECO:0000269

metaR SEBACIDTD
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR FOLt2le
is: SBO:0000185
name: folate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110048#

metaR ICDHyrm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000269
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
reversible: true
fast: false
name: Isocitrate dehydrogenase (NADP+)
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF

metaM HC02207 e
initial amount: NaN
name: prostaglandin-c2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false
is: CHEBI:27555
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0638
kinetic law: MODEL1310110048#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110048#

metaR Ser Thrtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
reversible: true
type: Reaction
name: Ser/Thr transport (from golgi to lysosome)
fast: false
reactant: MODEL1310110048#
is: SBO:0000185

metaM coa c
is: CHEBI:3312
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: C00010
is: SBO:0000247
constant: false
type: Species
name: Coenzyme A
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaM ksi pre36 g
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 36
has only substance units: false
is: CHEBI:28067
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
type: Species
constant: false
is: SBO:0000247

metaR r1551
reversible: true
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
is: SBO:0000185
product: MODEL1310110048#

metaR RIBt
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribose transport via diffusion

metaR PRISTCOAtcx
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR UMPK7
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000269
fast: false
product: MODEL1310110048#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dGTP)
reversible: true

metaR biomass reaction
is: SBO:0000185
name: biomass_reaction
is described by: ECO:0000134
kinetic law: MODEL1310110048#
reversible: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
type: Reaction
product: MODEL1310110048#

metaR r2085
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110048#
reversible: true
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110048#

metaM 3pg c
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3497
initial concentration: 1.0
is: C00197
is: CHEBI:58272
initial amount: NaN
type: Species
name: 3-Phospho-D-glycerate
has only substance units: false
constant: false
is: HMDB00807

metaR FUMSO3tm
fast: false
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfite antiport, mitochondrial
reversible: true
is described by: ECO:0000269
product: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#

metaR r0637
product: MODEL1310110048#
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110048#
type: Reaction
kinetic law: MODEL1310110048#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaM co2 c
is: C00011
name: CO2
is: CHEBI:3313
is: HMDB01967
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: CO2 CHARGE: 0

metaM cmp c
is: CHEBI:60377
is: HMDB00095
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: CMP
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
is: C00055

metaR ACGAM2E
name: N-acetylglucosamine 2-epimerase
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.8
reactant: MODEL1310110048#
fast: false
product: MODEL1310110048#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5973.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.8 Confidence Level: 4 AUTHORS: PMID:12499362 NOTES:NCD
reversible: true
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#

metaR SO4tl
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110048#
name: Sulfate transport (lysosome)
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_e9bb6d8d_c907_461f_83d9_67d3a98ed593
type: Species
is encoded by: hsa:279
has only substance units: false
initial amount: NaN
is: P04746
constant: false
initial concentration: NaN
name: AMY2A
is: SBO:0000252
boundary condition: true

metaR FAOXC184m
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR r1298
is described by: ECO:0000000
reactant: MODEL1310110048#
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction

metaM 5aop m
is: CHEBI:17549
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01149
name: 5-Amino-4-oxopentanoate
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247
is: C00430
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_554e3970_ccfe_467f_91a2_162d6c784a7d
is: Q5QPH3
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ACSS2
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55902
constant: false

metaR r1665
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_92eda560_dfc7_47ed_96ab_b30d9ddc5fc0
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2990
is: P08236
boundary condition: true
name: GUSB
is: SBO:0000252

metaR r0781
reversible: true
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is: SBO:0000176
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
modifier: MODEL1310110048#

metaR r1552
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110048#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#

metaM lys L c
is: HMDB00182
is: SBO:0000247
type: Species
initial amount: NaN
name: L-lysinium(1+)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
boundary condition: false
is: CHEBI:32551

metaM arg L e
initial concentration: 1.0
name: L-argininium(1+)
boundary condition: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
type: Species
is: SBO:0000247
is: HMDB00517
has only substance units: false
initial amount: NaN
constant: false

metaR r0636
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110048#
type: Reaction
product: MODEL1310110048#
is described by: ECO:0000000
modifier: MODEL1310110048#
reactant: MODEL1310110048#

metaM h n
constant: false
name: proton
has only substance units: false
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_2adb5366_a590_4c76_9457_43163d6c9b37
name: BAAT
initial concentration: NaN
type: Species
is encoded by: hsa:570
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q14032

http://identifiers.org/biomodels.db/MODEL1310110048#_29acd416_ad24_4670_a86e_44cda1b9c1f8
initial amount: NaN
name: HSD17B4
is encoded by: hsa:3295
type: Species
boundary condition: true
constant: false
is: E9PB82
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM o2 c
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
name: O2
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01377
is: CHEBI:15379
initial concentration: 1.0
is: C00007
type: Species

metaM nrpphr c
name: Norepinephrine
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
is: CHEBI:33569
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

metaR DM dgpi prot hs r
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_ab584c27_d861_41a3_b906_7892f2b4405b
boundary condition: true
is encoded by: hsa:64078
type: Species
is: Q9HAS3
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SLC28A3

metaM HC02207 c
is: SBO:0000247
name: prostaglandin-c2
initial amount: NaN
type: Species
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_e6b21d8f_f61a_4e05_8cc8_81088e81a03d
is encoded by: hsa:AW299740
name: _AW299740_1_m
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaR ACALDt
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110048#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: acetaldehyde reversible transport

http://identifiers.org/biomodels.db/MODEL1310110048#_4c78935e_2f5f_4f48_af09_ccb5116a8477
type: Species
has only substance units: false
name: SLC12A4
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: F5H066
initial concentration: NaN
is encoded by: hsa:6560

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM m2mpdol U c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
is: CHEBI:28049
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
is: SBO:0000247
constant: false

metaR r1666
kinetic law: MODEL1310110048#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110048#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185

metaM oxa c
has only substance units: false
type: Species
is: HMDB02329
name: oxalate(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

http://identifiers.org/biomodels.db/MODEL1310110048#_cd6327fd_64a2_4cc0_a2b8_2b13a2a11c5d
is encoded by: hsa:122622
initial amount: NaN
name: ADSSL1
is: SBO:0000252
is: B3KTV4
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_407b201a_7c24_40d1_aeb2_cb6b9f4a7c4e
name: ST3GAL3
boundary condition: true
has only substance units: false
is encoded by: hsa:6487
is: Q11203
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR ASPTAm
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
modifier: MODEL1310110048#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9e5eb655_8e57_43d3_8fb2_1775e8e35766
is encoded by: hsa:55512
name: SMPD3
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: A8K0T6
type: Species
initial amount: NaN
constant: false

metaR r1553
fast: false
reversible: true
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110048#

metaR PMTCOAtx
is described by: ECO:0000000
reactant: MODEL1310110048#
name: fatty acid intracellular transport
kinetic law: MODEL1310110048#
fast: false
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reversible: true

metaR r0780
is described by: ECO:0000000
modifier: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM asn L m
initial amount: NaN
boundary condition: false
is: HMDB00168
initial concentration: 1.0
name: L-asparagine
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species

metaR RE3218C
name: RE3218
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/3.1.6.2
is described by: ECO:0000000
type: Reaction
product: MODEL1310110048#

metaM HC01223 m
is: CHEBI:57340
boundary condition: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
constant: false
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM ocdca e
is: HMDB00827
is: CHEBI:25629
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: octadecanoate (n-C18:0)
is: SBO:0000247
is: C01530

metaM m1mpdol U c
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:28067
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR IPDDIx
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/5.3.3.2
fast: false
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
modifier: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000176
kinetic law: MODEL1310110048#
name: isopentenyl-diphosphate D-isomerase
reversible: true

metaM 3odcoa m
name: 3-Oxodecanoyl-CoA
initial amount: NaN
constant: false
type: Species
is: HMDB03939
is: SBO:0000247
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:28528

http://identifiers.org/biomodels.db/MODEL1310110048#_a9bcb4f6_4e38_4b30_9779_9fd20d8a523d
constant: false
boundary condition: true
initial amount: NaN
name: _U37519_1_c
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:U37519

http://identifiers.org/biomodels.db/MODEL1310110048#_bb7f5f9b_8a03_4c8c_988e_4e0548e002ad
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: ACSL1
is: P33121
is encoded by: hsa:2180
boundary condition: true
is: SBO:0000252
constant: false

metaR GLNSERNaEx
kinetic law: MODEL1310110048#
product: MODEL1310110048#
fast: false
is: SBO:0000185
type: Reaction
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110048#
reversible: false
modifier: MODEL1310110048#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR AG13T14g
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000
product: MODEL1310110048#
modifier: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110048#
is: SBO:0000176

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM chol r
type: Species
is: SBO:0000247
constant: false
is: HMDB00097
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
name: choline
is: CHEBI:15354
initial concentration: 1.0
initial amount: NaN

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM lys L e
is: HMDB00182
initial amount: NaN
type: Species
name: L-lysinium(1+)
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
is: SBO:0000247

metaR SERGLYexR
is: SBO:0000185
product: MODEL1310110048#
is described by: ECO:0000304
kinetic law: MODEL1310110048#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: L-Serine/Glycine reversible exchange
modifier: MODEL1310110048#
type: Reaction
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_c5f676c4_0b47_4dc9_8935_b42cfa134088
constant: false
is encoded by: hsa:10005
is: SBO:0000252
is: O14734
has only substance units: false
boundary condition: true
name: ACOT8
initial concentration: NaN
type: Species
initial amount: NaN

metaR UMPK2
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (CTP)
reactant: MODEL1310110048#
reversible: true
fast: false
modifier: MODEL1310110048#
is described by: ECO:0000269
product: MODEL1310110048#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_a1fa1704_2fbe_44a7_b98f_46d5181b5b8f
is: E9PAY8
boundary condition: true
initial concentration: NaN
type: Species
name: PPAP2C
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:8612
initial amount: NaN

metaR r1554
product: MODEL1310110048#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM akg x
is: SBO:0000247
is: HMDB00208
has only substance units: false
type: Species
constant: false
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 2-oxoglutarate(2-)

metaR r1667
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#

metaM tdec4ecoa m
is: HMDB00792
initial amount: NaN
type: Species
constant: false
name: trans4decenoylcoa
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C08277

metaR PROD2
modifier: MODEL1310110048#
is described by: ECO:0000254
product: MODEL1310110048#
is: SBO:0000176
type: Reaction
reversible: false
name: Proline dehydrogenase
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.5.99.8

metaM coa g
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: coenzyme A(4-)
is: HMDB01423
initial concentration: 1.0

metaM 1pyr5c c
initial amount: NaN
is: CHEBI:15893
is: C03912
name: 1-Pyrroline-5-carboxylate
is: HMDB01301
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR r0634
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000176
product: MODEL1310110048#
type: Reaction
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000

metaM prist x
is: HMDB00795
initial concentration: 1.0
initial amount: NaN
name: pristanic acid
is: CHEBI:51340
constant: false
type: Species
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_35cde04b_a461_4aee_a6b8_06eb72bf0ce7
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:50
name: ACO2
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q99798

http://identifiers.org/biomodels.db/MODEL1310110048#_7997619f_de21_4e7a_8439_9ebbbdd66812
constant: false
boundary condition: true
is encoded by: hsa:6470
is: P34896
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SHMT1
has only substance units: false

metaR r2082
type: Reaction
is: SBO:0000185
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
reversible: true
is described by: ECO:0000000
product: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR NADPHtru
reactant: MODEL1310110048#
product: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false
name: NADPH transporter, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110048#
type: Reaction

metaR SPMS
product: MODEL1310110048#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
modifier: MODEL1310110048#
name: spermidine synthase
reactant: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.5.1.16
kinetic law: MODEL1310110048#
type: Reaction
reversible: false
is described by: ECO:0000269

metaR CRNt
is: SBO:0000185
is described by: ECO:0000269
name: L-carnitine reversible transport
modifier: MODEL1310110048#
product: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reactant: MODEL1310110048#

metaM h l
boundary condition: false
is: SBO:0000247
is: CHEBI:24636
name: proton
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
is: http://identifiers.org/pubchem.compound/3380

metaR B3GNT39g
fast: false
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110048#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
reversible: false
reactant: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110048#

metaR r1299
type: Reaction
name: Vesicular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
kinetic law: MODEL1310110048#
product: MODEL1310110048#
reactant: MODEL1310110048#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110048#_110a425a_45e7_4b9b_a17b_6a7e212ee5d4
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:205
is: SBO:0000252
constant: false
boundary condition: true
name: AK4

metaR r0170
is: SBO:0000176
product: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
reactant: MODEL1310110048#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000

metaR r2080
is described by: ECO:0000000
kinetic law: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110048#
product: MODEL1310110048#
reversible: true
modifier: MODEL1310110048#
type: Reaction
fast: false

metaR FRUt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110048#
name: D-fructose transport via sodium cotransport
fast: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000185
modifier: MODEL1310110048#

metaR ILEt5m
name: Isoleucine mitochondrial transport
product: MODEL1310110048#
is described by: ECO:0000000
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110048#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_62bfcbcd_cf13_4e5b_9169_330b7885a933
is: E5KSL6
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1716
initial amount: NaN
constant: false
has only substance units: false
name: DGUOK

metaR r0633
is version of: http://identifiers.org/ec-code/2.7.7.3
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110048#
reactant: MODEL1310110048#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

metaM HC01444 e
name: Galactosylglycerol
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
has only substance units: false
is: CHEBI:15754
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_fb903bea_e9cb_48ae_857f_78b313e227b3
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3036
is: Q8IYH3
name: HAS1
has only substance units: false
type: Species

metaR UMPK3
is described by: ECO:0000269
product: MODEL1310110048#
name: UMP kinase (UTP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110048#
fast: false

metaM h m
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: http://identifiers.org/pubchem.compound/3380
name: proton
constant: false
has only substance units: false
is: C00080
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r1668
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110048#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110048#
modifier: MODEL1310110048#

metaM HC00361 c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:58335
type: Species
has only substance units: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
name: sedoheptulose 1,7-bisphosphate(4-)
constant: false

metaM CE4794 m
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57923
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
name: cis-6-dodecenoyl-CoA
type: Species
initial amount: NaN

metaM oxa e
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
type: Species
is: CHEBI:30623
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB02329
name: oxalate(2-)

metaM leuktrF4 e
is: CHEBI:27491
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
has only substance units: false
is: HMDB06465
name: leukotriene F4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110048#_84183c64_8c06_4029_9c40_a20e020a8a79
has only substance units: false
is encoded by: hsa:37
name: ACADVL
initial concentration: NaN
initial amount: NaN
is: P49748
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_a1aaccef_1b68_49a3_afd5_a406b8256c27
is: P48764
type: Species
is encoded by: hsa:6550
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC9A3

http://identifiers.org/biomodels.db/MODEL1310110048#_a6d2c89b_d1d7_4dec_970b_aa9f94f3bd18
is: SBO:0000252
initial amount: NaN
is: D9HTE9
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:6576
initial concentration: NaN
name: SLC25A1

metaM sphgn c
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: sphinganine(1+)
constant: false
is: CHEBI:57817
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
has only substance units: false
type: Species
is: HMDB00269

http://identifiers.org/biomodels.db/MODEL1310110048#_a9877f52_262c_42c8_9313_3e3b6632c729
boundary condition: true
has only substance units: false
name: FOLR1
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2348
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110048#_eaeb4ae8_c436_4162_8d3b_f30fcd6398e0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: PIGP
boundary condition: true
has only substance units: false
is encoded by: hsa:51227

metaM ocdca c
is: SBO:0000247
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
name: stearate
type: Species
is: HMDB00827
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

metaR r2081
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_15c601e7_a9fd_4e5c_9fde_44cf5a85d637
name: AMD1
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:262
constant: false
is: SBO:0000252
is: P17707
boundary condition: true

metaM pail34p hs c
initial concentration: 1.0
boundary condition: false
is: CHEBI:57658
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5

metaM co e
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
name: carbon monoxide
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
type: Species
boundary condition: false
is: CHEBI:17245
is: HMDB01361

metaR C226CPT1
name: carnitine C22:6 transferase
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
type: Reaction
fast: false
kinetic law: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110048#
reactant: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_274cf38b_d5db_4ac7_af50_a323103f4661
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3712
is: B3KVI7
initial amount: NaN
name: IVD
constant: false
has only substance units: false

metaM ksi e
has only substance units: false
initial concentration: 1.0
is: CHEBI:17268
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00211
boundary condition: false
constant: false
name: keratan sulfate I
notes: FORMULA: C247H393N17O213S12X CHARGE: -13

metaR AG13T5g
modifier: MODEL1310110048#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false
kinetic law: MODEL1310110048#
is described by: ECO:0000000
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110048#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110048#_b49f71c5_7a5f_4d2a_ba7c_7995949fa92c
has part: Q9HCC0
name: MCCC1:MCCC2
initial amount: NaN
is encoded by: hsa:56922
constant: false
is encoded by: hsa:64087
initial concentration: NaN
is: SBO:0000297
type: Species
boundary condition: true
has only substance units: false
has part: Q96RQ3

metaR RE3245C
fast: false
type: Reaction
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#
name: RE3245
is: SBO:0000176

metaR r1938
is described by: ECO:0000000
reversible: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110048#
reactant: MODEL1310110048#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110048#_5f91f718_3539_47c4_8d54_890c5d64e2cb
constant: false
name: ACP5
is: P13686
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:54
initial amount: NaN
initial concentration: NaN

metaM lthstrl r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:17168
type: Species
is: HMDB01170
boundary condition: false
name: 5alpha-cholest-7-en-3beta-ol

http://identifiers.org/biomodels.db/MODEL1310110048#_64b35c59_9dad_4e5b_a949_36380dd52cc9
has only substance units: false
is: Q06203
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5471
initial amount: NaN
constant: false
initial concentration: NaN
name: PPAT
type: Species

metaR r0311
fast: false
modifier: MODEL1310110048#
reversible: false
is: SBO:0000176
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110048#_33e88164_49b4_4bb6_a880_ccdac79e5a26
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4701
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: NDUFA7
is: Q6FG42

http://identifiers.org/biomodels.db/MODEL1310110048#_a1fe8f2c_f230_4369_89ce_57a01f9c2959
is encoded by: hsa:10455
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: O75521
type: Species
name: ECI2
initial concentration: NaN

metaM dhcholestanate c
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
boundary condition: false
is: HMDB00359
constant: false
has only substance units: false

metaM glyc R c
name: D-glycerate
constant: false
is: HMDB00139
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

http://identifiers.org/biomodels.db/MODEL1310110048#_81fcd206_22be_462f_ab1a_4d4a6176950a
constant: false
is: P49902
type: Species
initial amount: NaN
name: NT5C2
initial concentration: NaN
is encoded by: hsa:22978
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM Rtotal c
type: Species
is: CHEBI:16189
constant: false
is: HMDB01448
has only substance units: false
initial concentration: 1.0
name: R total
boundary condition: false
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110048#_440f6200_b440_4ce8_a081_4cdade92aa0a
has only substance units: false
boundary condition: true
is: Q9H6Y6
name: MYO5B
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4645

metaM phytcoa x
boundary condition: false
type: Species
is: HMDB01359
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
constant: false
name: phytanoyl-CoA(4-)
is: CHEBI:57391

metaR SMPD3g
type: Reaction
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.4.12
reversible: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
fast: false
is described by: ECO:0000304
is: SBO:0000176
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
product: MODEL1310110048#

metaR P45027A1m
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Cytochrome P450 27
fast: false
reversible: false
product: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
is: SBO:0000176
reactant: MODEL1310110048#
is described by: ECO:0000269

metaR ADNtm
product: MODEL1310110048#
name: adenosine facilated transport in mitochondria
type: Reaction
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
fast: false
modifier: MODEL1310110048#
is: SBO:0000185
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110048#_04560f29_2907_4209_9b9f_f8101abec30c
constant: false
type: Species
is encoded by: hsa:4842
initial amount: NaN
is: B4DG68
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NOS1

http://identifiers.org/biomodels.db/MODEL1310110048#_0ef8edec_b740_44a1_a6d0_0fd8bb5ffe42
initial amount: NaN
is: B4DP47
name: BCKDHA
constant: false
type: Species
is encoded by: hsa:593
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR DM gpi sig er
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaM ser L e
is: HMDB00187
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17115
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
name: L-serine

http://identifiers.org/biomodels.db/MODEL1310110048#_e59a9f43_874d_4fc8_bcf0_1cc4830bd615
name: SLC25A14
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9016
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR CRVNCtr
product: MODEL1310110048#
reversible: true
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110048#
fast: false

metaM ser D e
boundary condition: false
is: HMDB03406
initial amount: NaN
type: Species
name: D-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:16523

metaR C226CPT2
type: Reaction
reactant: MODEL1310110048#
product: MODEL1310110048#
name: C226 transport into the mitochondria
modifier: MODEL1310110048#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
kinetic law: MODEL1310110048#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
is: SBO:0000176

metaM dtmp e
initial concentration: 1.0
is: CHEBI:26999
name: dTMP(2-)
is: SBO:0000247
constant: false
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaM trdox c
is: CHEBI:18191
type: Species
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: SBO:0000247
initial amount: NaN
is: C00343
boundary condition: false
initial concentration: 1.0
constant: false
name: Oxidized thioredoxin
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_ecd2c02b_4059_474f_8809_3dbb7a308e5a
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:1384
boundary condition: true
name: CRAT

http://identifiers.org/biomodels.db/MODEL1310110048#_2416602e_521b_439b_8a0d_fe45925d00da
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3632
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: INPP5A
is: Q14642

http://identifiers.org/biomodels.db/MODEL1310110048#_454d19e8_f143_45ce_bf91_ab53a83d281a
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9469
constant: false
type: Species
has only substance units: false
is: Q7LGC8
name: CHST3
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110048#_60aa8d46_28eb_4276_a4e8_d02b57696394
type: Species
has part: Q5VYT2
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4731
is: SBO:0000297
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4712

http://identifiers.org/biomodels.db/MODEL1310110048#_a9f11643_2f7b_4bf6_a64e_d972513f281d
name: RHBG
type: Species
is: Q9H310
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:57127
constant: false
initial concentration: NaN

metaR RE2972M
name: RE2972
modifier: MODEL1310110048#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/2.7.1.67
product: MODEL1310110048#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
reactant: MODEL1310110048#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_fddfe79d_ebaa_4818_a2f8_a99e5b7d42ef
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O00217
initial amount: NaN
is encoded by: hsa:4728
name: NDUFS8
constant: false
type: Species

metaR DHCRD2
modifier: MODEL1310110048#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
name: dihydroceramide desaturase
is described by: ECO:0000269
kinetic law: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
fast: false
reactant: MODEL1310110048#

metaM omhdecacid r
initial amount: NaN
notes: FORMULA: C10H19O3 CHARGE: -1
type: Species
is: HMDB01022
is: SBO:0000247
name: w-hydroxydecanoicacid
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110048#_92eb9c8e_172e_4206_a88a_ef38a9c980c5
is encoded by: hsa:80308
initial concentration: NaN
name: FLAD1
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110048#
kinetic law: MODEL1310110048#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110048#
name: Organic anion transporter 5 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110048#_c83fb0fa_23af_4f6b_94f9_9377adac7f93
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q96KJ9
is encoded by: hsa:84701
boundary condition: true
constant: false
name: COX4I2
type: Species

metaM dag hs c
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
initial amount: NaN
name: diglyceride
is: CHEBI:18035
initial concentration: 1.0
has only substance units: false
type: Species

metaM ksi pre32 g
name: keratan sulfate I biosynthesis, precursor 32
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
is: CHEBI:28067
constant: false

metaM acac e
name: acetoacetate
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
is: CHEBI:13705

metaR RE1527M
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110048#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reversible: true
name: RE1527
modifier: MODEL1310110048#
reactant: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_4974413d_a4ea_464c_8dec_aaca104f3ed5
name: ACADM
initial concentration: NaN
is encoded by: hsa:34
initial amount: NaN
is: P11310
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaM co c
has only substance units: false
name: carbon monoxide
constant: false
is: SBO:0000247
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17245
initial concentration: 1.0
is: HMDB01361

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR H2Otg
kinetic law: MODEL1310110048#
reversible: true
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
is described by: ECO:0000000
name: H2O transport, Golgi apparatus
is: SBO:0000185
reactant: MODEL1310110048#

metaR UDPG4E
is described by: ECO:0000134
name: UDPglucose 4-epimerase
fast: false
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2
modifier: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_893d4fdf_197e_4ffc_992d_e435b7e8dcb5
initial amount: NaN
is encoded by: hsa:AI761708
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _AI761708_1_m
type: Species
is: SBO:0000252

metaR r0287
modifier: MODEL1310110048#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110048#
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#

metaR URAt
reversible: true
name: uracil transport via facilated diffusion
product: MODEL1310110048#
is: SBO:0000185
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110048#

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaR ALAt2r
reactant: MODEL1310110048#
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110048#
product: MODEL1310110048#
reversible: true
kinetic law: MODEL1310110048#
type: Reaction
fast: false
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110048#_1770dc0b_86ae_4ca8_9a7d_0bc3da3991d6
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: P28330
name: ACADL
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:33

http://identifiers.org/biomodels.db/MODEL1310110048#_72938eb1_17c9_4112_9300_a9502edd5371
initial amount: NaN
name: PI4KB
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9UBF8
is encoded by: hsa:5298
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110048#_6dbd5f68_e086_46cb_9b67_7ed5a26f9282
is: Q9Y673
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:29880
constant: false
initial concentration: NaN
name: ALG5

metaM fpram c
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C04640
is: HMDB06211
initial concentration: 1.0
type: Species
has only substance units: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
constant: false
is: CHEBI:58478
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640

http://identifiers.org/biomodels.db/MODEL1310110048#_f29d2a43_8fa5_44e0_b4fe_fd3b6642a931
type: Species
has only substance units: false
is encoded by: hsa:3037
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: HAS2
is: Q92819

metaR ADMDC
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
reversible: false
name: adenosylmethionine decarboxylase
modifier: MODEL1310110048#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.50
product: MODEL1310110048#
reactant: MODEL1310110048#
kinetic law: MODEL1310110048#
type: Reaction
is: SBO:0000176

metaR NACHEX25ly
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reactant: MODEL1310110048#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#

http://identifiers.org/biomodels.db/MODEL1310110048#_6fc8e152_9a93_4ece_aa0b_4adb8c0d3fbf
is: Q96RV2
name: HAS3
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3038
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaR r2360
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110048#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110048#
kinetic law: MODEL1310110048#
is described by: ECO:0000000
fast: false

metaM 10fthf7glu e
is: HMDB00108
has only substance units: false
is: CHEBI:16236
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](7)
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: SBO:0000247
constant: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110048#
reactant: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR XOLTRIOLtm
reactant: MODEL1310110048#
product: MODEL1310110048#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: lipid, flip-flop intracellular transport
type: Reaction
kinetic law: MODEL1310110048#

metaM prostgi2 e
type: Species
has only substance units: false
is: CHEBI:57403
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
is: HMDB01335
initial concentration: 1.0
constant: false
name: prostaglandin I2(1-)

metaM ser D c
name: D-serine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16523
constant: false
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
has only substance units: false

metaM dtmp c
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB01227
name: dTMP
is: CHEBI:26999
is: C00364

metaM ser L c
type: Species
is: CHEBI:17115
is: SBO:0000247
initial concentration: 1.0
is: HMDB00187
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
name: L-serine
boundary condition: false

metaR r1937
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110048#
reversible: false
kinetic law: MODEL1310110048#
modifier: MODEL1310110048#
product: MODEL1310110048#
type: Reaction
name: Y+LAT2 Utilized transport

metaR UREAt5
is: SBO:0000185
name: urea, water cotransport
reversible: true
product: MODEL1310110048#
reactant: MODEL1310110048#
type: Reaction
modifier: MODEL1310110048#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110048#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD

metaM ivcoa m
constant: false
is: HMDB01113
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
type: Species
initial concentration: 1.0
name: Isovaleryl-CoA
boundary condition: false
is: SBO:0000247
is: CHEBI:57345

metaM o2 m
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
constant: false
is: C00007
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:15379
is: SBO:0000247
initial amount: NaN

metaM chol e
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00114
is: HMDB00097
name: Choline
initial concentration: 1.0
type: Species
has only substance units: false

metaM 4ppcys c
is: CHEBI:59458
constant: false
is: HMDB01117
is: C04352
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: SBO:0000247
has only substance units: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
initial amount: NaN
type: Species
initial concentration: 1.0

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
reversible: true
product: MODEL1310110048#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
reactant: MODEL1310110048#
modifier: MODEL1310110048#
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110048#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false

http://identifiers.org/biomodels.db/MODEL1310110048#_9de626eb_b654_4053_8e2b_9c1e835b37e2
is: P00558
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5230
name: PGK1
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252