metaR H4ETer
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
type: Reaction
fast: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_c92bdbb4_3aa2_46d2_89f2_a69c865ba0a1
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10861
is: SBO:0000252
name: SLC26A1
initial concentration: NaN

metaR O2tm
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
fast: false
reactant: MODEL1310110047#
name: O2 transport (diffusion)

metaR GLNTHRNaEx
kinetic law: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
type: Reaction
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110047#
reversible: false

metaR r2310
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR PCHOLP hs
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110047#
fast: false
name: choline phosphatase
reversible: false

metaM r5p c
initial amount: NaN
name: alpha-D-Ribose 5-phosphate
has only substance units: false
is: C00117
constant: false
boundary condition: false
is: HMDB00618
is: CHEBI:18189
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117

metaR MG3er
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reactant: MODEL1310110047#

metaR DOLMANP Uter
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
is: SBO:0000185
type: Reaction
name: dolichol-phosphate mannose flippase (uterus)
kinetic law: MODEL1310110047#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaR r1646
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110047#

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: C05552
boundary condition: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
is: HMDB03134
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM ttetddcoa m
is: SBO:0000247
boundary condition: false
is: HMDB02288
constant: false
name: trans5,8tetradecadienoylcoa
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM guln c
is: HMDB03290
type: Species
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:13115
name: L-gulonate
boundary condition: false
constant: false
is: SBO:0000247

metaM bhb e
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:10983
boundary condition: false
type: Species
name: (R)-3-hydroxybutyrate
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011

metaR r2311
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_ca4414ab_8a1e_4216_97e7_32ce147b51a5
initial concentration: NaN
is encoded by: hsa:3028
type: Species
is: SBO:0000252
is: Q99714
name: HSD17B10
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
product: MODEL1310110047#
is: SBO:0000185

metaR CSPG Atly
name: chondroitin sulfate A transport, extracellular to lysosome
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110047#
fast: false
type: Reaction
is: SBO:0000185

metaM ksii core4 pre2 g
constant: false
boundary condition: false
has only substance units: false
is: HMDB00175
initial amount: NaN
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: CHEBI:58053
type: Species
is: SBO:0000247
is: C00130
name: keratan sulfate II boisynthesis, precursor 2
initial concentration: 1.0

metaM octdececoa c
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB06351
boundary condition: false
name: octadecenoylcoa
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM HC02208 e
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:27696
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
type: Species

metaR r1645
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaR r0129
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
is: SBO:0000176
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_83a5879d_c8c1_4b0c_b642_c660efcfaeea
constant: false
is encoded by: hsa:9245
name: GCNT3
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: O95395
has only substance units: false
initial amount: NaN

metaR NACHEX20ly
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_11cb6c5a_df41_42a5_a356_c7396d4fa8f0
boundary condition: true
initial concentration: NaN
name: PNP
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4860
is: SBO:0000252
is: P00491

metaM ctp e
initial amount: NaN
is: CHEBI:37563
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
initial concentration: 1.0
is: HMDB00082
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

metaM gpi sig r
boundary condition: false
is: CHEBI:58190
notes: FORMULA: Y CHARGE: 0
type: Species
has only substance units: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00224
constant: false

metaR r1644
product: MODEL1310110047#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_b2ceba8a_7512_43cc_9d72_99668bf7e2d1
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: B4DYG5
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5297
name: PI4KA

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM ethamp c
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species
is: SBO:0000247
name: ethamp[c]
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58190
is: HMDB00224
initial amount: NaN

metaM retinal 11 cis c
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB02152
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247
name: 11-cis-retinal
is: CHEBI:16066
type: Species
has only substance units: false
initial amount: NaN

metaR BALABETAtc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaM thmpp c
type: Species
initial concentration: 1.0
initial amount: NaN
name: Thiamine diphosphate
has only substance units: false
is: SBO:0000247
is: CHEBI:45931
constant: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
boundary condition: false
is: C00068
is: HMDB01372

metaR r0817
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is: SBO:0000185
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
modifier: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction

metaR 34DHOXPEGt
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_841eb008_d4bd_4b5a_a202_8d64a02366cc
type: Species
initial concentration: NaN
is encoded by: hsa:10157
initial amount: NaN
name: AASS
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: A4D0W4

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaR EX gumgchol LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-glycocholate complex
type: Reaction

metaM dag hs r
has only substance units: false
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
is: CHEBI:18035
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaM sbcoa x
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: suberylcoa
is: http://identifiers.org/pubchem.compound/16019966
constant: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial concentration: 1.0
has only substance units: false

metaM glyb c
constant: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
has only substance units: false
type: Species
name: glycine betaine
is: CHEBI:17750
boundary condition: false
is: SBO:0000247
is: HMDB00043

metaR ASPGLUm
type: Reaction
reactant: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
fast: false
reversible: true
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: aspartate-glutamate mitochondrial shuttle
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_33adc695_b6ca_42b0_9eab_2c3af3c445bc
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P27144
is encoded by: hsa:205
type: Species
constant: false
name: AK4
boundary condition: true

metaM pi x
constant: false
name: hydrogenphosphate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:43474
type: Species
has only substance units: false
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR r1643
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c9ac3c60_b328_4a2b_ad48_b570b0d7a24d
constant: false
is: Q9UJA2
name: CRLS1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:54675
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR r0818
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
fast: false
name: Transport reaction

metaR NADPtru
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: NADP transporter, endoplasmic reticulum
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_0f14dd3e_1f93_41eb_bb46_13c468320807
is encoded by: hsa:3423
constant: false
boundary condition: true
name: IDS
initial amount: NaN
is: P22304
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaM bhb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
name: (R)-3-hydroxybutyrate
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:10983
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaR LPASE
is version of: http://identifiers.org/ec-code/3.1.1.5
reversible: false
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
modifier: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: lysophospholipase
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_820f0381_f1c7_4076_8062_9a198d9ae2b1
is encoded by: hsa:84701
type: Species
has only substance units: false
is: Q96KJ9
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: COX4I2
initial concentration: NaN
constant: false

metaR GLYt7 211 r
is described by: ECO:0000269
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110047#
is: SBO:0000185
fast: false
name: glycine reversible transport via sodium and chloride symport (2:1:1)
type: Reaction
reactant: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#

metaM thf c
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01846
boundary condition: false
type: Species
is: CHEBI:57453
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
is: C00101
has only substance units: false

metaR DCSPTN1CPT1
product: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reactant: MODEL1310110047#
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110047#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_dd75ffab_4fdf_4905_95f5_1ba06853ef54
boundary condition: true
has only substance units: false
is encoded by: hsa:35
initial concentration: NaN
initial amount: NaN
is: P16219
type: Species
constant: false
is: SBO:0000252
name: ACADS

metaM ksii core4 pre3 g
is: HMDB00175
initial amount: NaN
type: Species
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 3
boundary condition: false
constant: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
has only substance units: false
is: C00130
is: CHEBI:58053
initial concentration: 1.0

metaR Q10H2e
is described by: ECO:0000134
product: MODEL1310110047#
name: transport of ubiquinol into lymph
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM ksi pre31 g
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00175
initial concentration: 1.0
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: SBO:0000247
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 31

metaR DMGDHm
is version of: http://identifiers.org/ec-code/1.5.99.2
type: Reaction
fast: false
reactant: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110047#
name: dimethylglycine dehydrogenase, mitochondrial
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (29958.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10767172,PMID:1123190 NOTES:MM
kinetic law: MODEL1310110047#

metaR ATP1ter
type: Reaction
reactant: MODEL1310110047#
reversible: true
is described by: ECO:0000000
product: MODEL1310110047#
name: ADP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110047#

metaM ksii core2 deg7 l
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00812
is: SBO:0000247
notes: FORMULA: C44H73N4O30X CHARGE: 0
boundary condition: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 7
is: CHEBI:16953

metaR HESTRATRIOLtr
reversible: true
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
reactant: MODEL1310110047#
name: hydroxylated estrogen derivative transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110047#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_d217965f_9ff1_4445_94b5_56d279725da9
type: Species
initial concentration: NaN
is encoded by: hsa:389015
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: Q6AI14
name: SLC9A4
has only substance units: false

metaR MGSA
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: methylglyoxal synthase
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
is described by: ECO:0000000
fast: false

metaM ksi deg41 l
is: CHEBI:12936
name: keratan sulfate I, degradation product 41
constant: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
is: HMDB00143
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM ksi pre18 g
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 18
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C00130
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110047#_3293d40e_0f6a_4955_9331_bee02fdd33d8
is encoded by: hsa:7360
type: Species
initial concentration: NaN
name: UGP2
is: SBO:0000252
constant: false
has only substance units: false
is: Q16851
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_b52ea1d1_ff8f_414e_9149_1986f12bbcd4
constant: false
initial amount: NaN
is: SBO:0000252
is: F8WDN9
boundary condition: true
type: Species
is encoded by: hsa:27068
initial concentration: NaN
name: PPA2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
type: Species
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
initial concentration: 1.0
is: HMDB00174
is: CHEBI:18287
initial amount: NaN

metaM acgam r
is: HMDB00215
name: N-acetyl-D-glucosamine
type: Species
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17411
initial amount: NaN

metaR r1649
product: MODEL1310110047#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
modifier: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#

metaR G14Tg
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is described by: ECO:0000269
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110047#_ffb89f7e_4458_478e_8d46_47e4d368cc72
is: SBO:0000252
is: Q14032
constant: false
initial amount: NaN
name: BAAT
is encoded by: hsa:570
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_cccc9bbe_cdbd_4c23_94b7_20e38d3a3963
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10948
is: SBO:0000252
type: Species
name: STARD3
is: B4DUY1
initial amount: NaN

metaM m4mpdol U r
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial amount: NaN
has only substance units: false
is: CHEBI:37633
boundary condition: false

metaM acmanap c
is: HMDB01121
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: N-acetyl-D-mannosamine 6-phosphate(2-)
boundary condition: false
is: CHEBI:58557
constant: false

metaM ksi deg7 l
name: keratan sulfate I, degradation product 7
constant: false
is: CHEBI:16953
has only substance units: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00812
boundary condition: false

metaR GPIAT
fast: false
name: glucosaminylphosphatidyl inositol acetyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_734909ca_425b_49c3_bd13_19699991e1bb
constant: false
is encoded by: hsa:6566
is: SBO:0000252
name: SLC16A1
is: B4DKS0
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

metaM dctp n
initial amount: NaN
initial concentration: 1.0
is: HMDB00998
boundary condition: false
type: Species
constant: false
name: dCTP
is: C00458
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311

metaM 3ddcrn c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00623
constant: false
has only substance units: false
notes: FORMULA: C19H37NO5 CHARGE: 0
name: 3-hydroxydodecanoylcarnitine
type: Species
boundary condition: false

metaM thf e
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01846
initial concentration: 1.0
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: SBO:0000247
type: Species
is: CHEBI:57453
boundary condition: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR FBP
is version of: http://identifiers.org/ec-code/3.1.3.11
reversible: false
name: fructose-bisphosphatase
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
type: Reaction
fast: false
is: SBO:0000176

metaR r1648
is: SBO:0000185
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
type: Species
is: CHEBI:26174
initial amount: NaN
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
has only substance units: false
boundary condition: false
constant: false

metaR UAG4E
kinetic law: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110047#
reactant: MODEL1310110047#
name: UDP-N-acetylglucosamine 4-epimerase
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_32879804_e3b2_4ec2_9c74_b0e5d63f35fb
is encoded by: hsa:1119
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: CHKA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_90f278af_93c7_4da4_862e_d4348fbafd2c
is: Q9Y303
initial amount: NaN
name: AMDHD2
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:51005
initial concentration: NaN

metaR DCSPTN1CPT2
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: carnitine transferase
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_044b64e5_7a2b_4cc4_b2fb_b5a10a9af0fd
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10998
name: SLC27A5
constant: false
initial amount: NaN
is: Q9Y2P5

metaR ADNK1m
reversible: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110047#
name: adenosine kinase, mitochondrial
type: Reaction
fast: false
product: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_425bb8ca_cbcc_45f3_84b7_64fdfe6ec2bf
boundary condition: true
initial amount: NaN
name: ELOVL6
constant: false
is: Q9H5J4
initial concentration: NaN
has only substance units: false
is encoded by: hsa:79071
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_18723643_a2ed_46c5_8341_37bec43aa991
is: P02730
initial concentration: NaN
type: Species
name: SLC4A1
boundary condition: true
is encoded by: hsa:6521
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR r1647
modifier: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110047#
product: MODEL1310110047#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110047#_9727fa8c_fdaa_4a02_bb0c_e8792a96c705
is encoded by: hsa:91703
boundary condition: true
is: SBO:0000252
is: Q96HD9
type: Species
name: ACY3
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

metaR FAOXC123C102x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaR EX adp
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaR PRO1x
type: Reaction
reversible: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
modifier: MODEL1310110047#
name: L-ProlineNAD+ 5-oxidoreductase
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
is described by: ECO:0000134

metaR NRPPHRtu
name: Norepinephrine uniport
reactant: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
is: SBO:0000185
product: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false

metaR G14T11g
modifier: MODEL1310110047#
reactant: MODEL1310110047#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110047#

metaR GCALDD
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110047#
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
name: Glycolaldehyde dehydrogenase
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR FAOXC12DCc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_aa7f39a8_0925_4166_8914_9acfd7c97ab3
is: P22413
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ENPP1
constant: false
is encoded by: hsa:5167
initial amount: NaN

metaR PROD2m
name: Proline dehydrogenase (m)
is described by: ECO:0000254
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.99.8
fast: false

metaR VLCS2p
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
modifier: MODEL1310110047#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
name: Very-long-chain-fatty-acid-CoA ligase
product: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
is: SBO:0000176
type: Reaction

metaR S6TASE10ly
product: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110047#

metaR RADH
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal dehydrogenase
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
reactant: MODEL1310110047#

metaM arachdcoa m
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
is: SBO:0000247
is: HMDB06523
has only substance units: false
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaM betald m
has only substance units: false
type: Species
is: HMDB01252
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
name: betaine aldehyde
boundary condition: false
initial concentration: 1.0
is: CHEBI:15710

http://identifiers.org/biomodels.db/MODEL1310110047#_bad1dfc2_e2ce_43bc_8eb7_808f70161e64
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: CPT1A
initial amount: NaN
is: Q8WZ48
is encoded by: hsa:1374

metaM dhcholestancoa r
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: CHEBI:15494
has only substance units: false
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
constant: false
initial amount: NaN
is: HMDB02159
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_c97e7436_1be3_4686_87e3_7b08290ca316
boundary condition: true
is: SBO:0000252
constant: false
name: AOC2
initial amount: NaN
has only substance units: false
is encoded by: hsa:314
is: O75106
type: Species
initial concentration: NaN

metaM ksi deg39 l
is: SBO:0000247
type: Species
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936
constant: false
initial amount: NaN
is: HMDB00143
name: keratan sulfate I, degradation product 39
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r0812
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#

metaM man1p c
name: D-Mannose 1-phosphate
is: HMDB06330
constant: false
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:35374
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_baef6a1c_cf19_45fd_8f79_b627c229edc5
name: INPP5J
initial amount: NaN
has only substance units: false
is encoded by: hsa:27124
is: SBO:0000252
is: Q15735
constant: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
boundary condition: false
is: HMDB00174
type: Species
constant: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
initial concentration: 1.0
is: CHEBI:18287

metaM 2dr1p c
is: C00672
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
is: SBO:0000247
is: HMDB01351
boundary condition: false
is: CHEBI:58576
constant: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM ocde9ecoa x
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
name: 9-octadecenoylcoa

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:27969
is: SBO:0000247
initial concentration: 1.0
name: Mesaconyl-CoA
has only substance units: false
constant: false
is: C06028

metaR MTHGXLt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reversible: false
fast: false
product: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: Methylglyoxal transport (cytosol to extracellular)
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_5d950214_220e_4d11_b35c_0e2321076414
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11001
boundary condition: true
name: SLC27A2
is: O14975
constant: false
has only substance units: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_f5991bef_8006_4eb2_8f75_75f87fe37173
type: Species
initial concentration: NaN
is: O15254
is encoded by: hsa:8310
name: ACOX3
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaM fdp c
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16905
is: HMDB01058
initial concentration: 1.0
name: D-Fructose 1,6-bisphosphate
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3647
constant: false
type: Species
is: C00354
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354

metaR CAATPS
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
kinetic law: MODEL1310110047#
type: Reaction
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000269
name: Ca ATPase
modifier: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.8

http://identifiers.org/biomodels.db/MODEL1310110047#_631495dd_3db3_4cf0_a73b_40bb5b8f6744
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: Q8IV97
name: SLC7A5
is encoded by: hsa:8140
constant: false

metaR VLCS2r
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
is described by: ECO:0000304
name: Very-long-chain-fatty-acid-CoA ligase
type: Reaction
fast: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_7250052a_4583_49ca_b98e_0d45c1543848
type: Species
name: PLA2G2D
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:26279
has only substance units: false
constant: false
is: SBO:0000252
is: Q9UNK4

http://identifiers.org/biomodels.db/MODEL1310110047#_f5ca2d4e_4e99_48c9_a76e_a8d935666736
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1609
is: P52824
constant: false
type: Species
has only substance units: false
name: DGKQ

metaM dctp c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998
has only substance units: false
name: dCTP
type: Species
initial amount: NaN
is: C00458
initial concentration: 1.0
is: CHEBI:16311
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_63e90020_cb5e_4180_bb71_0ac40f754a15
initial amount: NaN
is: SBO:0000252
is: Q8TCD5
constant: false
name: NT5C
initial concentration: NaN
is encoded by: hsa:30833
boundary condition: true
type: Species
has only substance units: false

metaM octdececoa m
name: octadecenoylcoa
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false

metaM 3hbcoa m
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01166
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: CHEBI:57316
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_00a11e4e_2ed4_4d51_8892_5ff15718fde6
is: Q9NUB1
name: ACSS1
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84532

http://identifiers.org/biomodels.db/MODEL1310110047#_c89d8f5d_04a5_42c0_9f20_ccb3350e385f
name: DPM1
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:8813
has only substance units: false
initial amount: NaN
is: O60762

metaR GMAND
name: GDP-D-mannose dehydratase
type: Reaction
is described by: ECO:0000000
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.47
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_09f91edf_811e_42b1_aac2_1cf34a7d019c
is encoded by: hsa:10861
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: SLC26A1
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f860a019_33a7_43d0_a174_9fea7658330d
name: FOLR3
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:2352
is: SBO:0000252
is: Q05C14
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_026fb713_a4c2_4ae3_8924_b49f74ca8788
has only substance units: false
is encoded by: hsa:6533
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9BRI2
name: SLC6A6

http://identifiers.org/biomodels.db/MODEL1310110047#_14e144f7_d0be_4c47_b4ab_261e060543d3
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: PDE8A
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110047#_75a48413_42fc_4c66_8019_7ba807947919
type: Species
has only substance units: false
constant: false
name: PIK3C2A
is: O00443
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5286
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
is: CHEBI:15824
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
boundary condition: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
type: Species
is: HMDB00660
initial concentration: 1.0
has only substance units: false
is: C00095
constant: false

metaM tmndnccoa x
is: SBO:0000247
is: HMDB06514
has only substance units: false
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: timnodonyl coenzyme A

metaM thymd c
constant: false
boundary condition: false
is: CHEBI:17748
has only substance units: false
initial concentration: 1.0
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: SBO:0000247
type: Species
name: Thymidine
initial amount: NaN
is: HMDB00273

metaR PGDI
is described by: ECO:0000269
name: Prostaglandin-H2 D-isomerase [Precursor]
is version of: http://identifiers.org/ec-code/5.3.99.2
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
product: MODEL1310110047#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.18
modifier: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_90f882e2_49af_46cd_b3ce_58ed6143eb4e
is: SBO:0000252
name: AOC2
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:314

http://identifiers.org/biomodels.db/MODEL1310110047#_8f738bb0_6e92_42e9_9c32_81a6ff1a8703
type: Species
initial concentration: NaN
name: SLC6A9
is: B7Z3W8
constant: false
has only substance units: false
is encoded by: hsa:6536
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM dmgly m
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7) EHMN_ABBREVIATION: C01026
is: CHEBI:17724
name: N,N-dimethylglycine
is: HMDB00092
boundary condition: false
initial concentration: 1.0
type: Species

metaR r1755
reactant: MODEL1310110047#
name: Y+LAT2 Utilized transport
product: MODEL1310110047#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
type: Reaction
reversible: false
modifier: MODEL1310110047#

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_783feaba_8e16_4319_9253_c2a499ede88e
initial amount: NaN
has only substance units: false
type: Species
name: ADSL
boundary condition: true
constant: false
is encoded by: hsa:158
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_d3258b6b_ed2c_47bd_811e_cb744064aaaf
constant: false
initial amount: NaN
name: ALOX5
has only substance units: false
is encoded by: hsa:240
is: P09917
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaR S6TASE18ly
reactant: MODEL1310110047#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_00fb6dcb_5261_4dca_a27c_2a81956bd25f
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:5091
name: PC
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaR DPHMBDCm
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaM ctp c
has only substance units: false
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00082
is: SBO:0000247
is: C00063
initial amount: NaN
type: Species

metaR RE3346M
reversible: true
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
name: RE3346
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is: SBO:0000176

metaM ibcoa m
is: CHEBI:57338
is: HMDB01243
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
name: isobutyryl-CoA(4-)

metaR r1642
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#

metaR NACHEX3ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
modifier: MODEL1310110047#
reversible: false
fast: false

metaR PCm
reactant: MODEL1310110047#
reversible: false
fast: false
is described by: ECO:0000269
name: pyruvate carboxylase
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
is version of: http://identifiers.org/ec-code/6.4.1.1
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
is: SBO:0000176

metaR PHYHx
product: MODEL1310110047#
is: SBO:0000176
name: Phytanoyl-CoA dioxygenase, peroxisomal
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.11.18
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110047#

metaR GLYCLTtp
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: glycolate transport into peroxisome
is: SBO:0000185

metaM 2decdicoa m
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
name: 2,7-decadienoylcoa
type: Species
boundary condition: false

metaR TDCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
is described by: ECO:0000000
product: MODEL1310110047#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_817f9abb_89cf_46a0_a8b8_24276602ea18
name: PTGIS
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q16647
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:5740
is: SBO:0000252

metaM amp e
has only substance units: false
constant: false
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
type: Species
is: C00020
is: HMDB00045
initial amount: NaN
initial concentration: 1.0
name: AMP
boundary condition: false

metaR r2420
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaR PHEMEt
name: heme transport
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
is: SBO:0000185

metaR r0525
name: N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase; N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) Lysine degradation EC:1.5.1.9
type: Reaction
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000000
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.9 Confidence Level: 0 AUTHORS: PMID:235294,PMID:4774398 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_539a5f5e_c150_496d_b965_0014826a2373
initial concentration: NaN
name: MGAT1
boundary condition: true
has only substance units: false
is: P26572
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4245

metaM q10 e
constant: false
is: HMDB01072
initial concentration: 1.0
name: ubiquinone-10
initial amount: NaN
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:46245

metaR r1641
is: SBO:0000185
reversible: true
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f1086d57_7a45_494c_bc87_2f5a028f955e
initial amount: NaN
is: O00462
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4126
boundary condition: true
name: MANBA
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_f4b56124_31a3_4e31_a062_b22129b73198
is encoded by: hsa:8897
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: MTMR3

metaR DOPASFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
name: Dopamine 3-0-sulfate transport (diffusion)
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_0e642509_3b06_434a_a81f_71482a72623a
initial concentration: NaN
constant: false
boundary condition: true
is: Q9Y6M9
has only substance units: false
is encoded by: hsa:4715
initial amount: NaN
is: SBO:0000252
type: Species
name: NDUFB9

http://identifiers.org/biomodels.db/MODEL1310110047#_2f879858_0e27_4caa_aebf_5f526402f699
name: AMACR
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:23600
constant: false
boundary condition: true
is: SBO:0000252
is: Q3KT79

http://identifiers.org/biomodels.db/MODEL1310110047#_2e7c6278_9a55_43c9_89a0_2188e117b920
is: SBO:0000252
name: SORD
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6652
type: Species
initial concentration: NaN
is: Q00796

metaR r0522
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
reversible: false
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_6e292404_9af1_478d_b2fa_7fe84d7112b7
is: Q6FGA0
is encoded by: hsa:9167
has only substance units: false
boundary condition: true
name: COX7A2L
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_c05b0087_0231_4263_832a_bc1225afd293
name: ENTPD1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q86VV3
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:953
type: Species

metaM cholp c
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:295975
name: choline phosphate(1-)
type: Species
initial amount: NaN

metaM pail35p hs c
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57923
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
boundary condition: false
has only substance units: false

metaR RE3367E
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
name: RE3367
is: SBO:0000176
kinetic law: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
is described by: ECO:0000000

metaR r1640
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR r1753
reactant: MODEL1310110047#
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
fast: false
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_20dc9b28_261e_4d2b_82e3_b9aa26361408
name: ALG8
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:79053
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_c2e33aa3_2a35_4592_98f7_460a602a99ce
constant: false
boundary condition: true
name: NME1:NME2
type: Species
initial concentration: NaN
initial amount: NaN
has part: P15531
has part: P22392
is encoded by: hsa:4831
is: SBO:0000297
has only substance units: false
is encoded by: hsa:4830

metaM dhcholestancoa x
type: Species
initial concentration: 1.0
is: HMDB02159
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
has only substance units: false
initial amount: NaN
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
name: blood group intracellular transport
fast: false
is: SBO:0000185
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_1e33b2a4_6880_4eae_b579_4dc10789d1f9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10768
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: AHCYL1
is: O43865

metaM q10 c
boundary condition: false
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: HMDB01072
type: Species
initial concentration: 1.0
is: CHEBI:46245
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false

metaR r0523
kinetic law: MODEL1310110047#
is: SBO:0000176
type: Reaction
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
modifier: MODEL1310110047#
product: MODEL1310110047#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR ALAGLNNaEx
is described by: ECO:0000269
reversible: false
is: SBO:0000185
fast: false
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_b846b07a_a55c_460b_a767_a2116a8b4b88
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11112
initial amount: NaN
boundary condition: true
type: Species
is: P31937
name: HIBADH

metaR FACOAL2042
reversible: true
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110047#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110047#

metaM tethex3coa c
boundary condition: false
initial concentration: 1.0
is: C16168
is: HMDB06243
constant: false
name: tetracosahexaenoyl coenzyme A
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
is: http://identifiers.org/pubchem.compound/47205478
has only substance units: false

metaM amp c
is: CHEBI:3322
name: AMP
is: HMDB00045
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: C00020
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_e2b8cb48_f8df_4ebc_af50_98e46e3e89b2
is encoded by: hsa:3163
is: SBO:0000252
is: P30519
name: HMOX2
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_1bca6955_f4e3_4098_a4b3_b6c0324cf7a2
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:175
initial amount: NaN
initial concentration: NaN
is: P20933
name: AGA
has only substance units: false

metaM acgam l
name: N-acetyl-D-glucosamine
is: CHEBI:17411
is: SBO:0000247
has only substance units: false
is: HMDB00215
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR G14T8g
modifier: MODEL1310110047#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000

metaM HC01609 e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
name: UroporphyrinogenI
boundary condition: false
is: CHEBI:28766
type: Species
has only substance units: false

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false
is: SBO:0000247
type: Species
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: CHEBI:57795
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r0236
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
reversible: true
fast: false
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110047#

metaM 4fumacac c
is: HMDB01268
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
has only substance units: false
constant: false
is: CHEBI:18034
name: 4-fumarylacetoacetate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_6ea8519c_d441_42bf_8f79_d4841aef512b
is: SBO:0000252
type: Species
is encoded by: hsa:1608
name: DGKG
constant: false
has only substance units: false
is: P49619
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM r5p r
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
is: HMDB00618
boundary condition: false
is: CHEBI:18189
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: alpha-D-Ribose 5-phosphate
type: Species
has only substance units: false

metaR FAOXC204C184m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaM pi g
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
type: Species
has only substance units: false
name: hydrogenphosphate
initial concentration: 1.0
boundary condition: false
is: CHEBI:43474
initial amount: NaN
constant: false
is: SBO:0000247

metaR r0517
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#

metaM hdcoa m
type: Species
initial amount: NaN
name: Hexadecenoyl-CoA (n-C16:1CoA)
has only substance units: false
is: HMDB06532
initial concentration: 1.0
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247

metaM Lcystin e
is: CHEBI:16283
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-cystine
type: Species
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
constant: false
is: HMDB00192

http://identifiers.org/biomodels.db/MODEL1310110047#_5fda328b_55ea_4242_ac91_4f3b2539554e
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110047#_f08c1404_4f2c_42d5_b9c7_a4bf653e8c89
boundary condition: true
initial amount: NaN
has only substance units: false
name: RDH13
type: Species
initial concentration: NaN
is: B3KVA3
is encoded by: hsa:112724
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_b1b5b425_fee5_468d_a26b_75c7b1deaf32
name: SLC7A8:SLC3A2
initial amount: NaN
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:23428
type: Species
has part: Q9UHI5
constant: false
initial concentration: NaN

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR GLYt7 311 r
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
is: SBO:0000185
product: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
fast: false
is described by: ECO:0000006

metaR r2198
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110047#

metaR HSD3B11
type: Reaction
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
reversible: false
kinetic law: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
is described by: ECO:0000134

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM lnlnca c
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01388
name: alpha-linolenate
is: CHEBI:32387
boundary condition: false
has only substance units: false
constant: false

metaM ksii core4 pre1 g
initial concentration: 1.0
notes: FORMULA: C36H60N3O25X CHARGE: 0
constant: false
type: Species
initial amount: NaN
is: CHEBI:28067
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 1
has only substance units: false
is: SBO:0000247

metaM ethamp r
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: O-phosphonatoethanaminium(1-)
constant: false
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
is: HMDB00224
initial concentration: 1.0

metaM HC02207 c
is: SBO:0000247
initial concentration: 1.0
constant: false
name: prostaglandin-c2
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
is: CHEBI:27555
initial amount: NaN
type: Species

metaM orot5p c
is: HMDB00218
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57538
boundary condition: false
is: SBO:0000247
constant: false
name: Orotidine 5'-phosphate
initial amount: NaN
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: C01103

metaM dag hs c
constant: false
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:18035
type: Species

metaR RE1516M
is described by: ECO:0000000
name: RE1516
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR EX 3ddcrn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_c41aa23a_0998_4d6c_aea8_3226fbb2701d
name: NDUFA1
boundary condition: true
is encoded by: hsa:4694
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: Q6IBB5

http://identifiers.org/biomodels.db/MODEL1310110047#_95106987_83a8_4a53_afb5_1babc4e63f44
is: P14060
type: Species
name: HSD3B1
has only substance units: false
is encoded by: hsa:3283
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaR r0672
is: SBO:0000176
modifier: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
reversible: true
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:

metaR FUMtm
name: fumarate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110047#
is: SBO:0000185

metaM adn m
is: HMDB00050
is: SBO:0000247
name: adenosine
is: CHEBI:16335
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
type: Species

metaM ksi pre29 g
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
constant: false
initial amount: NaN
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 29
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:28067
is: SBO:0000247

metaR Htx
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110047#
fast: false
name: H transporter, peroxisome
product: MODEL1310110047#

metaM cholp g
has only substance units: false
is: C00588
is: SBO:0000247
name: choline phosphate(1-)
is: CHEBI:295975
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM lnlnca e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01388
is: CHEBI:32387
constant: false
name: alpha-linolenate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_9b476bd9_8f79_47cc_bb7d_c70255b8380c
boundary condition: true
name: GPD1
initial amount: NaN
has only substance units: false
is: F8W1L5
initial concentration: NaN
constant: false
is encoded by: hsa:2819
is: SBO:0000252
type: Species

metaM ksi pre20 g
is: CHEBI:28067
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 20
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
constant: false
is: SBO:0000247
boundary condition: false
type: Species

metaR O2Stx
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (peroxisome)
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_197aef70_a67a_4121_a7e0_eb14baaf24e7
is encoded by: hsa:272
boundary condition: true
initial concentration: NaN
name: AMPD3
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: B7Z763

metaR ALOX52
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000269
reversible: false
name: Arachidonate 5-lipoxygenase

http://identifiers.org/biomodels.db/MODEL1310110047#_82b50a5f_a3f7_4922_bbab_627884b65b47
is: Q9NY64
type: Species
has only substance units: false
constant: false
boundary condition: true
name: SLC2A8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:29988

metaR r0671
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110047#
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
reversible: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.22
fast: false

metaM CE5114 x
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,20-21,28-30,34-36,40,51-52H,4-7,10,13,16-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5114
is: CHEBI:57923
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_ffc79d2f_410b_4457_a695_d8d75ccd0371
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: ADCY3
constant: false
is: SBO:0000252
is: B3KT86
is encoded by: hsa:109
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_eea2d288_37c1_49f6_a39a_ebcf9be8445a
type: Species
is encoded by: hsa:9517
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SPTLC2
constant: false
initial amount: NaN
is: O15270
is: SBO:0000252

metaM dmgly c
constant: false
is: HMDB00092
boundary condition: false
is: CHEBI:17724
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: N,N-dimethylglycine
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7) EHMN_ABBREVIATION: C01026

metaR ENGASEly
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110047#
reversible: false
fast: false

metaM HC02207 e
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
initial concentration: 1.0
is: CHEBI:27555
initial amount: NaN
is: SBO:0000247
constant: false
name: prostaglandin-c2
boundary condition: false

metaM 2decdicoa x
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 2,7-decadienoylcoa
type: Species
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110047#_4174c23a_b1b2_4492_8970_4335a34fd349
name: SLC7A10
type: Species
has only substance units: false
constant: false
is: Q9NS82
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:56301
is: SBO:0000252

metaM aacoa c
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
is: SBO:0000247
name: Acetoacetyl-CoA
initial concentration: 1.0
initial amount: NaN
is: C00332
constant: false
is: HMDB01484
is: CHEBI:57286
has only substance units: false

metaR EX tetdece1crn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaR 3AIBt
reversible: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
name: 3-amino-isobutyrate transport
type: Reaction
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT

metaR RE1530C
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_2dc6bddc_a07c_4ffd_b8b6_b7e51499cf11
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:6482
is: Q11201
name: ST3GAL1
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR RE2677E
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
reversible: false
name: RE2677
is described by: ECO:0000000
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_f47bf16a_c2d6_4cee_bc53_2da95a8e5a98
type: Species
has only substance units: false
is encoded by: hsa:5150
name: PDE7A
constant: false
is: SBO:0000252
initial amount: NaN
is: Q13946
boundary condition: true
initial concentration: NaN

metaM glyb m
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species
is: SBO:0000247
is: CHEBI:17750
is: HMDB00043
constant: false
boundary condition: false
initial amount: NaN
name: glycine betaine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_4bb6a819_39d4_4a15_a17e_be97e5d5d1d6
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: PDE8A
is encoded by: hsa:5151
type: Species
is: SBO:0000252
boundary condition: true

metaR RE0935E
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
fast: false
name: RE0935
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_26b2c688_81fc_456d_8d69_2ed7b35f3387
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: ST3GAL3
is encoded by: hsa:6487

http://identifiers.org/biomodels.db/MODEL1310110047#_c3f89fe4_1303_4cef_b2c9_f4c67493cbe1
is: SBO:0000252
is: Q6FH11
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: HMOX1
constant: false
is encoded by: hsa:3162
initial concentration: NaN

metaR S6TASE21ly
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

metaM dag hs e
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:18035
boundary condition: false
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
has only substance units: false

metaM melatn c
has only substance units: false
is: HMDB01389
name: melatonin
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
type: Species
boundary condition: false
is: CHEBI:16796

metaM 3hanthrn c
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01476
initial concentration: 1.0
constant: false
name: 3-hydroxyanthranilate
is: CHEBI:36559
boundary condition: false
type: Species
notes: FORMULA: C7H7NO3 CHARGE: 0 INCHI: InChI=1S/C7H7NO3/c8-6-4(7(10)11)2-1-3-5(6)9/h1-3,9H,8H2,(H,10,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00464 EHMN_ABBREVIATION: C00632

metaR C162ACBP
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaM pydxn c
initial concentration: 1.0
is: HMDB00239
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: Pyridoxine
constant: false
initial amount: NaN
is: C00314
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: CHEBI:16709

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM m4mpdol U c
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633

metaM hmgcoa c
is: HMDB01375
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15467
constant: false
initial amount: NaN
has only substance units: false
name: Hydroxymethylglutaryl-CoA
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR B3GALT3g
is described by: ECO:0000269
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110047#
name: Beta-1,3-galactosyltransferase 3
is: SBO:0000176
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.79
reversible: false
type: Reaction

metaR S6T16g
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
type: Reaction
fast: false
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR PSt3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false
type: Reaction
reactant: MODEL1310110047#
reversible: true
name: phosphatidylserine transport
kinetic law: MODEL1310110047#
is described by: ECO:0000269
product: MODEL1310110047#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_3859da07_214d_49dd_a395_17bc2825cc57
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5833
is: F5H8B1
type: Species
initial concentration: NaN
name: PCYT2

http://identifiers.org/biomodels.db/MODEL1310110047#_32ca201c_8f38_4962_8cc3_51d37326b39f
is encoded by: hsa:9517
type: Species
is: SBO:0000297
has part: O15270
name: SPTLC1:SPTLC2
boundary condition: true
has part: O15269
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:10558
has only substance units: false

metaR FAOXC5C5DCc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM itaccoa m
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57381
boundary condition: false
has only substance units: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: HMDB03377
name: itaconyl-CoA(5-)
constant: false

metaR NACHEX16ly
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal

metaR ASPDTDe
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
kinetic law: MODEL1310110047#
is: SBO:0000185
fast: false
reactant: MODEL1310110047#
reversible: true
type: Reaction
name: D-aspartate transport, extracellular
is described by: ECO:0000134

metaM fuc1p L c
has only substance units: false
type: Species
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
name: L-Fucose 1-phosphate
is: CHEBI:28319
constant: false
initial amount: NaN
is: HMDB01265
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR MAL Lte
reversible: true
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#
name: Transport of L-malate

metaR FAOXC2452256x
reactant: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110047#
name: Beta oxidation of long chain fatty acid
reversible: false

metaM pi m
is: CHEBI:43474
is: SBO:0000247
is: C00009
has only substance units: false
is: HMDB00973
name: hydrogenphosphate
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_4f0cf613_2bdd_43b3_b042_4c43644a265c
is encoded by: hsa:4522
initial amount: NaN
name: MTHFD1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: P11586

metaM hexe3coa x
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
name: 3-hexenoylcoa
has only substance units: false
type: Species
is: HMDB06522

metaM tetpent6coa x
name: tetracosapentaenoyl coenzyme A, n-6
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: C16172
is: SBO:0000247
type: Species
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1

metaM Lcystin c
has only substance units: false
constant: false
is: CHEBI:16283
initial amount: NaN
initial concentration: 1.0
type: Species
name: L-cystine
is: SBO:0000247
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
boundary condition: false

metaR S6T8g
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110047#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false

metaM 4hbz m
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
is: HMDB00500
is: SBO:0000247
is: CHEBI:17879
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 4-hydroxybenzoate
type: Species
constant: false
boundary condition: false

metaM 2docopencoa m
is: SBO:0000247
initial concentration: 1.0
name: 2,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790

http://identifiers.org/biomodels.db/MODEL1310110047#_f431a3fe_b7d4_4807_8544_bedfe81ee7a0
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3419
is: P50213
name: IDH3A
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8503e1aa_8bda_4830_acff_c59bfb9250cb
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6542
initial amount: NaN
has only substance units: false
name: SLC7A2
type: Species
is: SBO:0000252
is: P52569

metaR G14T10g
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
reactant: MODEL1310110047#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3470e2ce_ff71_44b9_b092_15734922edb6
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q9NRR6
is encoded by: hsa:56623
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: INPP5E

metaM asp D c
is: HMDB06483
type: Species
initial concentration: 1.0
initial amount: NaN
name: D-aspartate(1-)
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: CHEBI:29990
constant: false
has only substance units: false
boundary condition: false

metaM 10fthf5glu e
is: SBO:0000247
type: Species
is: CHEBI:57454
constant: false
has only substance units: false
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](5)
initial amount: NaN
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: HMDB00972
boundary condition: false

metaM pi l
type: Species
name: hydrogenphosphate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:43474
is: HMDB00973
constant: false
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_cfedcc5c_c26d_420d_a7f5_b185e2cc511c
is encoded by: hsa:MBOAT5
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _MBOAT5_1_c
constant: false
is: SBO:0000252
boundary condition: true

metaR r2319
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
type: Reaction
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_0932ec24_d9d2_4e4b_a3f0_6c4afe4b1f91
name: B3GNT5
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:84002
is: Q9BYG0
initial amount: NaN
has only substance units: false

metaR HOMt4
is: SBO:0000185
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: L-homoserine via sodium symport
fast: false
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000269

metaM chol n
initial concentration: 1.0
name: choline
initial amount: NaN
is: SBO:0000247
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
constant: false
type: Species
boundary condition: false
has only substance units: false

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR Htr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
fast: false
is: SBO:0000185
reversible: true
name: H transporter, endoplasmic reticulum

metaR DHORD9
reversible: false
fast: false
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.2
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is described by: ECO:0000269
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: dihydoorotic acid dehydrogenase (quinone10)

metaM bhb m
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
initial amount: NaN
is: SBO:0000247
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00011
constant: false

metaM urate e
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: Urate
is: SBO:0000247
is: C00366
is: HMDB00289
is: CHEBI:17775

metaR LTC4CP
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
name: Leukotriene C4 carboxypeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reactant: MODEL1310110047#
product: MODEL1310110047#

metaM Lcyst c
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB02757
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
constant: false
name: L-cysteate(1-)
type: Species
is: CHEBI:58090
initial concentration: 1.0
initial amount: NaN

metaR PI4P3K
name: phosphatidylinositol 4-phosphate 3-kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110047#
fast: false
is: SBO:0000176
modifier: MODEL1310110047#

metaM thbpt c
is: SBO:0000247
constant: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: HMDB00027
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:15372
type: Species
name: 5,6,7,8-tetrahydrobiopterin

metaR INSTt4 2
fast: false
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000006
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: inositol transport via sodium symport
reversible: true
type: Reaction
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD

metaR r2318
reactant: MODEL1310110047#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110047#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110047#

metaM apoC Lys btn c
has only substance units: false
initial amount: NaN
constant: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: CHEBI:32551
type: Species

metaM chol m
has only substance units: false
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00097
is: SBO:0000247
name: choline

metaM pi n
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
boundary condition: false
type: Species
is: CHEBI:43474
is: SBO:0000247
name: hydrogenphosphate
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_eebdbb6c_df51_4c5d_957a_034dccf44c03
type: Species
initial concentration: NaN
constant: false
name: SLCO1A2
has only substance units: false
initial amount: NaN
is: P46721
is encoded by: hsa:6579
boundary condition: true
is: SBO:0000252

metaR G12MT2 U
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110047#

metaM asp D e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:29990
is: HMDB06483
name: D-aspartate(1-)

metaR CAT2p
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.11.1.6 Confidence Level: 2 AUTHORS: PMID:19382904,PMID:19382905,PMID:8769411 NOTES:NCD
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.11.1.6
type: Reaction
is: SBO:0000176
name: catalase A, peroxisomal (ethanol)
product: MODEL1310110047#

metaM docoscoa x
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB12930
boundary condition: false
name: docosanoylcoa

metaR C162OHc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR TCYNTtm
name: Thiocyanate transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110047#
fast: false
reversible: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaM fpram c
is: HMDB06211
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: SBO:0000247
is: C04640
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:58478

metaR S6TASE9ly
type: Reaction
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
reversible: true
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR UDPACGALtl
reversible: true
name: udpacgal intracellular transport
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
product: MODEL1310110047#
type: Reaction
fast: false

metaM 3ddcrn e
is: C02838
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H37NO5 CHARGE: 0
constant: false
has only substance units: false
type: Species
name: 3-hydroxydodecanoylcarnitine
initial amount: NaN
initial concentration: 1.0
is: HMDB00791

metaR RE3218C
is: SBO:0000176
product: MODEL1310110047#
name: RE3218
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
reversible: true
kinetic law: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.2
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_1379b5b7_d3f0_4c7e_9f81_49ca0ac9c2e5
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:728441
boundary condition: true
name: GGT2
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR IVCRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR r2317
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_aae60ac2_3153_478a_bbe3_4411dd72a9f6
constant: false
is encoded by: hsa:51109
name: RDH11
type: Species
initial amount: NaN
is: B4DDW0
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR H2Otly
is: SBO:0000185
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
fast: false
type: Reaction
name: H2O transport, lysosomal
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000

metaM ctp m
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:37563
is: HMDB00082
boundary condition: false
name: CTP(4-)
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
has only substance units: false

metaR r1639
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaM 3hodcoa c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
constant: false
is: HMDB13336
name: (S)-3-Hydroxyoctadecanoyl-CoA
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR FAOXC9C7m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_bf3f9bcc_8e9f_46e7_9f94_f5cb6a47c19d
name: _BE966236_1_m
is encoded by: hsa:BE966236
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_7ef0aa0c_91b9_4948_81c1_715aa7140e2d
name: ND4
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4538
boundary condition: true
is: P03905
initial amount: NaN
initial concentration: NaN

metaR BTNPLm
is described by: ECO:0000000
type: Reaction
fast: false
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
product: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#

metaR OIVD1m
name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000269
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.168

http://identifiers.org/biomodels.db/MODEL1310110047#_9babb328_f3e3_41b1_b613_2d442316a34d
type: Species
is encoded by: hsa:1345
boundary condition: true
name: COX6C
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P09669
constant: false
has only substance units: false

metaM pser L c
boundary condition: false
has only substance units: false
name: O-Phospho-L-serine
is: CHEBI:15811
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01721
initial amount: NaN
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
type: Species

metaR r2316
reactant: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110047#
type: Reaction

metaR RE3346C
name: RE3346
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110047#
is: SBO:0000176
type: Reaction
product: MODEL1310110047#

metaM ctp n
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
name: CTP(4-)
type: Species
is: CHEBI:37563
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_45dc0b79_7f6c_4b77_acc7_17ff3c010493
name: _AA177072_1_x
constant: false
is encoded by: hsa:AA177072
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR S2TASE3ly
is: SBO:0000176
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: iduronate-2-sulfatase, lysosomal
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110047#

metaR r1030
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
name: Transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:

metaM dhap x
is: HMDB01473
is: C00111
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: CHEBI:57642
name: Dihydroxyacetone phosphate

metaR C162OHe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaR r0679
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000000

metaR DM fol
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_38bf3b3c_0d77_4182_b455_41cb00b810a9
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: Q9H477
is encoded by: hsa:64080
initial concentration: NaN
initial amount: NaN
name: RBKS

metaM met L e
is: CHEBI:16643
is: HMDB00696
name: L-methionine
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0

metaR r0973
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true
name: Facilitated diffusion

metaR 34HPPOR
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.27
fast: false
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110047#
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_ca8084bf_4429_4c08_b1b1_f00d9bc15276
is: SBO:0000252
is: B3KU59
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC8A3
is encoded by: hsa:6547

metaR PI45P5P
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110047#
reversible: false

metaR FAOXC163Gm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM 2docopencoa x
is: http://identifiers.org/pubchem.compound/24892790
constant: false
is: SBO:0000247
type: Species
name: 2,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaR TETPENT6t
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110047#_fcd665ec_85b7_4e79_b1ac_5592917675c3
boundary condition: true
type: Species
name: PIK3R1
constant: false
has only substance units: false
is: P27986
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5295

metaR NACHEX27ly
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
fast: false
modifier: MODEL1310110047#
type: Reaction
reversible: false
kinetic law: MODEL1310110047#
is described by: ECO:0000269
reactant: MODEL1310110047#
product: MODEL1310110047#

metaR r2315
is: SBO:0000185
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_4f51b932_d628_480d_9987_6f3fc5925b4e
constant: false
is: Q6IA69
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: NADSYN1
has only substance units: false
is encoded by: hsa:55191

http://identifiers.org/biomodels.db/MODEL1310110047#_939615ae_e796_4ace_a39a_8a17eb828937
is: Q96CA6
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:30
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ACAA1
constant: false

metaR OCDEAFABP1tc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of octadecenoyl coA into the enterocytes
type: Reaction

metaR GDPFUCtg
name: GDPFuc Golgi transport via CMP antiport
product: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction

metaM glyb e
is: HMDB00043
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
is: CHEBI:17750
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: glycine betaine
type: Species

metaM sphmyln hs c
constant: false
has only substance units: false
type: Species
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
is: CHEBI:58216
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_f0dfda10_2104_4602_aad1_ad80226c9502
boundary condition: true
type: Species
name: LCT
constant: false
is: SBO:0000252
is: P09848
is encoded by: hsa:3938
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR FAOXC102C81x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_3c4c0e30_a342_4c8e_91ea_655049ed9619
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:3098
initial amount: NaN
is: A8K7J7
is: SBO:0000252
name: HK1

metaR FATP1t
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
fast: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: fatty acid electroneutral transport
reversible: true
is: SBO:0000185
product: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000269

metaR HISCAT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM pi r
boundary condition: false
is: CHEBI:43474
initial amount: NaN
type: Species
is: HMDB00973
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0

metaR r2314
type: Reaction
product: MODEL1310110047#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#

metaM 44mzym r
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
constant: false
is: CHEBI:18364
type: Species
is: HMDB01286
name: 14-demethyllanosterol
initial concentration: 1.0
boundary condition: false

metaR ADK1m
modifier: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
product: MODEL1310110047#
name: adenylate kinase, mitochondrial
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.3

http://identifiers.org/biomodels.db/MODEL1310110047#_85f136cc_633c_4cf4_bfc4_31f7d7b30d67
constant: false
is: Q9H2U2
initial amount: NaN
name: PPA2
type: Species
has only substance units: false
is encoded by: hsa:27068
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM maltpt e
is: HMDB01296
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: maltopentaose
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: C02052
initial amount: NaN
is: SBO:0000247

metaM met L c
name: L-methionine
has only substance units: false
is: CHEBI:16643
boundary condition: false
is: HMDB00696
type: Species
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR ORPT
name: orotate phosphoribosyltransferase
reversible: true
modifier: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
reactant: MODEL1310110047#
is: SBO:0000176
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
kinetic law: MODEL1310110047#

metaR FAOXC12DCx
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR GLCter
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
name: glucose transport, endoplasmic reticulum
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_82120276_a219_4759_bc92_0eef92b49b58
is: SBO:0000252
name: AK4
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: P27144
type: Species
is encoded by: hsa:205
initial concentration: NaN

metaR r2313
reversible: true
is: SBO:0000185
product: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110047#
type: Reaction

metaR MM6B2g
modifier: MODEL1310110047#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110047#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_8290e2f5_5356_419b_8836_ab6a0fec22bb
is: SBO:0000252
constant: false
is: O14975
name: SLC27A2
is encoded by: hsa:11001
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_3ad2a050_b093_428c_a144_b2947d89afaa
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: ACOT6
boundary condition: true
is encoded by: hsa:641372
is: Q3I5F7
has only substance units: false
is: SBO:0000252

metaM urate c
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Urate
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:17775
is: C00366
is: HMDB00289
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

metaR CYANt
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
product: MODEL1310110047#
name: Cyanide transport via diffusion (extracellular to cytosol)
is: SBO:0000185
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_59ba9e46_efc5_4fb8_b1b0_8dbbdcf67d51
name: NDUFB6
has only substance units: false
is: O95139
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:4712
is: SBO:0000252
initial concentration: NaN

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_dc74f857_50cc_4ac4_981f_b7473da01287
boundary condition: true
has only substance units: false
name: LGALS13
constant: false
type: Species
is: Q9UHV8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29124

metaM thf m
initial amount: NaN
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
is: C00101
is: CHEBI:57453
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaR C12DCACOT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_1c88224b_4e79_43fc_a047_8d0069eea12e
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: _AI769281_1_e
is encoded by: hsa:AI769281

metaR DECDICRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR FAOXC24C22x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

metaR r2312
product: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaM betald c
is: HMDB01252
initial concentration: 1.0
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
initial amount: NaN
is: CHEBI:15710
type: Species
boundary condition: false
name: betaine aldehyde
constant: false
is: SBO:0000247

metaM arachdcoa c
is: HMDB06523
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57368
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_d397ac15_b371_4864_8c11_2c0405b105c6
boundary condition: true
has only substance units: false
is: Q9BT22
type: Species
is encoded by: hsa:56052
name: ALG1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM nh4 e
initial amount: NaN
is: HMDB00051
is: CHEBI:28938
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: ammonium
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR GALSIDEtg
reactant: MODEL1310110047#
type: Reaction
name: galactocerebroside intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
kinetic law: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
is: SBO:0000185
fast: false

metaM ivcrn c
is: HMDB00688
notes: FORMULA: C12H23NO4 CHARGE: 0
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: isovaleryl carnitine
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_761a2f45_ae29_4bb0_8ceb_9929f530054c
name: SDHA
is: P31040
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6389
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_18924c35_bb7d_4fc2_8cb0_690f109ff4e9
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: _AW299740_1_m
boundary condition: true
is encoded by: hsa:AW299740

http://identifiers.org/biomodels.db/MODEL1310110047#_a344f6ed_bcaa_40cd_b5fd_2dcb3321e7e6
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9NVS9
is encoded by: hsa:55163
name: PNPO
boundary condition: true

metaM sphings l
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: SBO:0000247
is: HMDB00252
name: sphingosine(1+)
type: Species
constant: false
is: CHEBI:57756

metaR FAOXC16180m
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000176
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR r1632
modifier: MODEL1310110047#
reversible: true
type: Reaction
product: MODEL1310110047#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110047#

metaM chol c
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00114
constant: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
is: HMDB00097
initial amount: NaN
is: CHEBI:15354
name: Choline

http://identifiers.org/biomodels.db/MODEL1310110047#_fc39854d_b6b3_4127_9fdf_214a668caf42
initial amount: NaN
is encoded by: hsa:5213
name: PFKM:PFKP
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
has part: P08237
type: Species
is: SBO:0000297

metaR PSFLIPm
is described by: ECO:0000269
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.1
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
type: Reaction
name: phosphatidylserine flippase

metaR Htg
name: proton diffusion (Golgi)
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110047#

metaM c226coa c
boundary condition: false
name: cervonyl coenzyme A
has only substance units: false
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
type: Species
constant: false

metaM ksii core2 deg3 l
constant: false
name: keratan sulfate II (core 2-linked), degradation product 3
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaR CSBPASEly
product: MODEL1310110047#
reversible: false
is described by: ECO:0000000
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
is: SBO:0000176
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false

metaR GGH 7DHFe
name: Gamma-glutamyl hydrolase (7DHF), extracellular
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
modifier: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaR RE1807M
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110047#
name: RE1807
reactant: MODEL1310110047#

metaM xu5p D c
is: CHEBI:57737
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00868
constant: false
name: D-xylulose 5-phosphate(2-)
has only substance units: false

metaM 34dhoxmand m
is: HMDB01866
is: SBO:0000247
initial amount: NaN
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
type: Species
initial concentration: 1.0
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
has only substance units: false
constant: false
boundary condition: false

metaM 3hexdtricoa x
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02288
initial amount: NaN
type: Species
name: 3,7,10-hexadecatrienoylcoa
initial concentration: 1.0

metaR r1631
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM lnlccoa r
is: HMDB01064
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR SERDGLNexR
is described by: ECO:0000304
fast: false
name: D-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110047#

metaR GGT6
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
reversible: true
name: Gamma-glutamyltransferase
fast: false
reactant: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ

metaR r0139
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
modifier: MODEL1310110047#
product: MODEL1310110047#
fast: false
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110047#

metaM odecrn m
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
has only substance units: false
initial concentration: 1.0
is: C00412
initial amount: NaN
name: octadecenoyl carnitine
type: Species
boundary condition: false
is: CHEBI:57394
constant: false
is: HMDB01114
is: SBO:0000247

metaR TDCHOLAtx
reversible: true
name: bile acid intracellular transport
product: MODEL1310110047#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
fast: false

metaM hxcoa m
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06522
name: Hexanoyl-CoA (n-C6:0CoA)
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_43eb8d4a_641d_45d7_b645_8f112364a26c
is: SBO:0000252
is encoded by: hsa:55907
constant: false
boundary condition: true
type: Species
name: CMAS
is: Q8NFW8
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR FAOXC141C121x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaM hmgcoa x
is: CHEBI:15467
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01375
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_1731e80e_2238_439f_85e4_b925492bb1c1
is encoded by: hsa:4713
name: NDUFB7
constant: false
is: P17568
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM ivcrn e
initial amount: NaN
notes: FORMULA: C12H23NO4 CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
name: isovaleryl carnitine
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00688

metaR r0097
reactant: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
product: MODEL1310110047#
reversible: false

metaM CE0713 m
is: HMDB02329
has only substance units: false
boundary condition: false
constant: false
name: 3-oxolinoleoyl-CoA
initial concentration: 1.0
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:30623

http://identifiers.org/biomodels.db/MODEL1310110047#_d8fb8990_8819_40ca_b14f_3f8daaea59b7
initial amount: NaN
boundary condition: true
is encoded by: hsa:23530
name: NNT
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR CYTK8
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110047#
reversible: true
type: Reaction
fast: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110047#
is: SBO:0000176
name: cytidylate kinase (CMP,dATP)

http://identifiers.org/biomodels.db/MODEL1310110047#_bdddc8a5_47e8_413d_9c87_948784fbec42
boundary condition: true
is encoded by: hsa:2731
is: SBO:0000252
constant: false
initial amount: NaN
name: GLDC
has only substance units: false
type: Species
initial concentration: NaN
is: P23378

metaM chol e
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
is: CHEBI:15354
is: SBO:0000247
name: Choline
is: C00114

metaR BTNt4i
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110047#
modifier: MODEL1310110047#
name: Biotin uptake (antiport)
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT

metaR C161CRNt
name: C161 transport into the mitochondria
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
product: MODEL1310110047#

metaR r1634
reversible: true
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110047#

metaR PTPATe
type: Reaction
product: MODEL1310110047#
reversible: true
is: SBO:0000176
name: PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_151edeff_a916_480a_a26f_6e89f3480d38
type: Species
is encoded by: hsa:3939
has part: P07195
is: SBO:0000297
initial concentration: NaN
constant: false
name: LDHA:LDHB
has part: P00338
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3945

metaR 4ABUTtm
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
name: 4-aminobutanoate mitochondrial transport via diffusion
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_1b1cf2f2_73b4_406b_a06c_b08a2968f76d
constant: false
is: C9JT23
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: NDUFA11
initial amount: NaN
is encoded by: hsa:126328

metaR FAOXC102C81m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR ACCOAgt
name: acetyl-coa transport
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
modifier: MODEL1310110047#
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_6c66200d_db25_4fc9_a155_a8eeaac2a2a9
has only substance units: false
initial amount: NaN
name: XDH
type: Species
boundary condition: true
is encoded by: hsa:7498
constant: false
is: SBO:0000252
initial concentration: NaN
is: P47989

http://identifiers.org/biomodels.db/MODEL1310110047#_e1cd60b3_f66c_4bc9_86ea_ff7a0e315250
type: Species
name: TM7SF2
is: O76062
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7108

metaR DITPtn
fast: false
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110047#
is: SBO:0000185
name: dITP nuclear transport
kinetic law: MODEL1310110047#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_f1829453_75f1_4bf8_b8d9_781aec1cb5f9
is: SBO:0000252
is encoded by: hsa:8525
constant: false
type: Species
is: B7Z2M9
initial concentration: NaN
has only substance units: false
boundary condition: true
name: DGKZ
initial amount: NaN

metaR CYTK9
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dCTP)
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000269
reactant: MODEL1310110047#

metaM n2m2nm l
has only substance units: false
constant: false
is: HMDB00573
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: n2m2nmasn (w/o peptide linkage)
is: CHEBI:30825
notes: FORMULA: C58H97N5O41 CHARGE: 0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_15c86818_ed92_46b9_babb_f32f704a5530
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: ST3GAL3
is encoded by: hsa:6487
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_1e1720f7_aef9_4047_9672_19039aa9b07e
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:100
type: Species
is: P00813
has only substance units: false
boundary condition: true
name: ADA
initial amount: NaN

metaR r1633
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM tetde5coa x
constant: false
is: HMDB13109
type: Species
name: 5-tetradecenoylcoa
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_f1040e4a_1bc7_42b2_9bb2_01d301d5ce7a
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AI653169_1_c
initial concentration: NaN
is encoded by: hsa:AI653169
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_c32285dc_1f31_40c1_a619_3ee5ad7e08fa
name: PANK1
is encoded by: hsa:53354
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaM ump r
type: Species
is: HMDB00288
name: UMP
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false

metaM xylt e
is: HMDB02917
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
name: xylitol
is: SBO:0000247
is: CHEBI:17151
constant: false

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_7abb68ce_644c_4b96_942f_6bdde4f40631
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110047#_3a72d83e_48f1_497d_abd0_d0940c9596b5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q5JRA6
is encoded by: hsa:375056
type: Species
has only substance units: false
constant: false
name: MIA3

metaR PPBNGS
modifier: MODEL1310110047#
name: porphobilinogen synthase
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.24
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaM 1pyr5c m
boundary condition: false
is: SBO:0000247
type: Species
name: 1-Pyrroline-5-carboxylate
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: C03912
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:15893
initial amount: NaN
is: HMDB01301

metaM cs b deg2 l
is: CHEBI:16953
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: HMDB00812
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2

http://identifiers.org/biomodels.db/MODEL1310110047#_215d5d26_24de_465f_81ae_7558199955ba
has only substance units: false
initial amount: NaN
type: Species
is: Q59FD4
initial concentration: NaN
is encoded by: hsa:3098
constant: false
name: HK1
boundary condition: true
is: SBO:0000252

metaR r0801
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is: SBO:0000185
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
reactant: MODEL1310110047#
reversible: true

metaR B MANNASEly
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction
fast: false
modifier: MODEL1310110047#
name: beta-mannosidase, lysosomal
is: SBO:0000176
product: MODEL1310110047#

metaR HDCACBP
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM gal14acglcgalgluside hs g
name: Lactoneotetraosylceramide
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
type: Species
is: CHEBI:17103
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_979688b2_e005_431c_81a1_902653b93738
boundary condition: true
is: Q1LZ56
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC36A1
type: Species
has only substance units: false
is encoded by: hsa:206358
initial concentration: NaN

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR C18OHc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaR r1785
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_967de66a_5e33_4244_9f3e_7b92e0fd0e1b
initial amount: NaN
has only substance units: false
is: Q96T66
name: NMNAT3
type: Species
constant: false
boundary condition: true
is encoded by: hsa:349565
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_3c9aa9ba_e89a_4a06_a16d_1f5eed4d786c
name: MVD
is encoded by: hsa:4597
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: P53602

metaR MM8Ber
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110047#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
modifier: MODEL1310110047#

metaR r1636
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaR EX tdcrn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaM f1p c
is: C01094
type: Species
is: CHEBI:18105
is: HMDB01076
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: D-Fructose 1-phosphate
constant: false
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_eb6617d2_14c4_4d69_9c3e_35469c1a6126
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4125
boundary condition: true
initial concentration: NaN
name: MAN2B1
has only substance units: false
is: O00754

metaR r1487
is described by: ECO:0000000
name: EC:6.2.1.3
is: SBO:0000176
reversible: true
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM ksi deg28 l
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
is: HMDB00812
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 28
type: Species
has only substance units: false
is: CHEBI:16953

metaR PROD2
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
name: Proline dehydrogenase
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.99.8

http://identifiers.org/biomodels.db/MODEL1310110047#_bcf55320_3aaa_4688_aa6e_f2d029501f9b
boundary condition: true
is: Q13907
is encoded by: hsa:3422
initial amount: NaN
initial concentration: NaN
constant: false
name: IDI1
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3143244d_e70a_4f00_ad56_9882fb670c71
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:53354
is: Q8TE04
boundary condition: true
name: PANK1

metaM cs b deg3 l
constant: false
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
is: CHEBI:21338
initial concentration: 1.0
is: HMDB02704
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial amount: NaN

metaM 5pmev c
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
name: (R)-5-phosphonatomevalonate(3-)
boundary condition: false
is: HMDB01343
is: SBO:0000247
has only substance units: false

metaR r1784
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
fast: false

metaM sebacid x
name: sebacicacid
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H16O4 CHARGE: -2
constant: false
boundary condition: false
has only substance units: false
is: C08277
is: HMDB00792

metaR r1635
product: MODEL1310110047#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM xylt c
boundary condition: false
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
initial amount: NaN
type: Species
name: xylitol
is: SBO:0000247
is: CHEBI:17151
initial concentration: 1.0
is: HMDB02917

http://identifiers.org/biomodels.db/MODEL1310110047#_e28b123d_e852_498e_9630_e7d035e33e0a
is: Q71UM8
initial concentration: NaN
is encoded by: hsa:108
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ADCY2
type: Species
constant: false
has only substance units: false

metaM aacoa m
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
constant: false
is: CHEBI:57286
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: acetoacetyl-CoA(4-)

metaM 3spyr c
name: 3-sulfonatopyruvate(2-)
is: CHEBI:57940
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
has only substance units: false
is: HMDB04045
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_d34d9f1e_2f46_4bef_9428_53db2affce40
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: NDUFS2
initial amount: NaN
is: B7Z792
is encoded by: hsa:4720

metaR r0093
product: MODEL1310110047#
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
is: SBO:0000176
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.3
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
fast: false
is described by: ECO:0000000

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:28938
initial concentration: 1.0
constant: false
has only substance units: false
is: C01342
name: Ammonium
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_0323be37_18b2_40ad_8207_9d48321e3ff2
is: Q96IJ6
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:29926
initial amount: NaN
name: GMPPA
type: Species
initial concentration: NaN
is: SBO:0000252

metaR HAS1
is described by: ECO:0000269
reversible: false
name: hyaluronan synthase
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.212
type: Reaction
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_f7ccc1b6_5aa1_4390_aeca_f7f016ee8f7e
is: SBO:0000252
is: P08195
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6520
initial concentration: NaN
name: SLC3A2

metaR r1638
kinetic law: MODEL1310110047#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110047#_6d73a838_7502_4ac8_aeed_235313ee4632
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AA526438
type: Species
name: _AA526438_1_c
initial concentration: NaN

metaR ACGAM2E
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (5973.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.8 Confidence Level: 4 AUTHORS: PMID:12499362 NOTES:NCD
is: SBO:0000176
name: N-acetylglucosamine 2-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.8
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000269
reversible: true

metaR S6TASE17ly
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaR r1786
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110047#
reversible: false
fast: false
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_537a885b_f2f2_4068_9394_ba7538bca53d
name: GRHPR
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:9380
is: Q9UBQ7
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_787e2c3a_89ac_464e_a244_307c2d67758a
initial concentration: NaN
name: DDOST
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1650
initial amount: NaN
type: Species
is: P39656
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_bb20ad9e_4285_45ce_a0af_668124993211
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _HG2846_HT2983_1_c
constant: false

metaR AHC
type: Reaction
name: adenosylhomocysteinase
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.3.1.1
product: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
reversible: true
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_9adb6a49_6b32_4569_acff_d42e5de25085
is: SBO:0000297
initial amount: NaN
has only substance units: false
is encoded by: hsa:55350
initial concentration: NaN
name: VNN3:VNN2:VNN1
type: Species
boundary condition: true
constant: false

metaR r1637
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
modifier: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM nrvnccoa c
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: nervonyl coenzyme A
has only substance units: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
is: C16532
type: Species
initial amount: NaN

metaR UDPGLCter
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000000
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
reversible: true
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_de1a996a_4185_4cb6_b095_8bc372622b4c
initial concentration: NaN
is encoded by: hsa:116369
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: SLC26A8
constant: false

metaR r1745
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110047#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
fast: false

metaM thm c
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:0
name: Thiamin
has only substance units: false
is: HMDB00235
type: Species
notes: FORMULA: C12H17N4OS CHARGE: 1
is: C00378
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_4b54314f_6280_443b_b438_f446e341f1db
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: CA5A
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:763
has only substance units: false
is: P35218

metaM ump g
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
constant: false
name: UMP(2-)
is: CHEBI:57865
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00288

http://identifiers.org/biomodels.db/MODEL1310110047#_147d0640_485d_40e5_bdd8_152a1a7df5e3
has only substance units: false
boundary condition: true
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has part: Q86U05
type: Species
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
constant: false

metaM so4 e
name: sulfate
initial amount: NaN
is: CHEBI:16189
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01448
boundary condition: false
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_768569a3_2e69_4cc1_a8b3_4d4c722bf18a
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: Q8TCG5
constant: false
name: CPT1C
is encoded by: hsa:126129
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_4be41970_0b93_45cc_b9e1_98ecff77d44b
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: GUCY1B3
type: Species
initial amount: NaN
is encoded by: hsa:2983
is: Q02153

http://identifiers.org/biomodels.db/MODEL1310110047#_b49be4e3_3130_4635_97ba_55deea40e7bb
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2876
constant: false
boundary condition: true
name: GPX1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_289730dc_834e_40e5_8bd0_2607e025c3e9
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR SERGLYexR
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
name: L-Serine/Glycine reversible exchange
is described by: ECO:0000304
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110047#
is: SBO:0000185

metaM 1pyr5c c
constant: false
has only substance units: false
is: CHEBI:15893
is: C03912
is: SBO:0000247
is: HMDB01301
name: 1-Pyrroline-5-carboxylate
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaM zym int2 r
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:52386
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
name: zymosterol intermediate 2
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_8f4359a6_91ff_498d_984e_3ace261fe088
type: Species
is: P49441
has only substance units: false
initial amount: NaN
constant: false
name: INPP1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3628

metaR 2HCO3 NAt
is: SBO:0000185
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110047#
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#

metaR r0531
fast: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
is: SBO:0000176
reversible: true
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_261b59ca_808f_4928_a633_0a97b5a0a94d
has only substance units: false
name: ATP2B1
is encoded by: hsa:490
is: P20020
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR 3MOPte
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
name: Transport of 3-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

metaR r1788
type: Reaction
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM c226coa m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
constant: false
type: Species

metaR r1378
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is: SBO:0000176
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reactant: MODEL1310110047#
product: MODEL1310110047#
reversible: true

metaR r2193
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
type: Reaction
modifier: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110047#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000

metaM ppi x
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
constant: false
name: Diphosphate
is: C00013
is: HMDB00250
type: Species

metaM pmtcrn c
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17490
name: L-palmitoylcarnitine
initial concentration: 1.0
type: Species
constant: false
is: HMDB00222

metaM HC01403 x
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
name: (S)-Hydroxydecanoyl-CoA
initial amount: NaN
constant: false
is: CHEBI:28325

metaM btamp c
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial amount: NaN
boundary condition: false
name: Biotinyl-5'-AMP
is: SBO:0000247
is: HMDB04220
is: CHEBI:3110

metaM 3hexdtricoa m
initial concentration: 1.0
name: 3,7,10-hexadecatrienoylcoa
is: HMDB02288
constant: false
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110047#_c32e03e9_6356_4fc0_8588_4e2317f94190
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI818585
type: Species
constant: false
name: _AI818585_1_c
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c6e334ed_224d_4d83_9078_26c46814dae4
has only substance units: false
constant: false
boundary condition: true
name: ANPEP
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: Q59E93
is encoded by: hsa:290

http://identifiers.org/biomodels.db/MODEL1310110047#_ab447e53_9ca8_4c89_acb5_f722edf29f38
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4907
is: P21589
constant: false
has only substance units: false
name: NT5E
type: Species
initial concentration: NaN

metaM so4 c
is: HMDB01448
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
is: SBO:0000247
name: sulfate
is: CHEBI:16189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_5abc9704_da75_4c1c_bb50_d89db3a9212c
is: SBO:0000252
type: Species
name: GAMT
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:2593
initial amount: NaN
has only substance units: false

metaR RE1448N
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reactant: MODEL1310110047#
name: RE1448

http://identifiers.org/biomodels.db/MODEL1310110047#_7520042e_80b6_4b89_8a88_adc6a48dceec
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:224
initial concentration: NaN
name: ALDH3A2
is: P51648
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_ea49c8f6_28aa_4396_a2c4_cf825f75365d
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: PDE9A
is encoded by: hsa:5152

metaR r0245
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
modifier: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
fast: false

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR r1377
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is: SBO:0000176
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false

metaR R group phosphotase 1
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#
name: R group phosphotase 1
reactant: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_1889ea9e_c9ea_48f4_a202_cb6505d50d32
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:AA203143
type: Species
initial amount: NaN
initial concentration: NaN
name: _AA203143_1_c
boundary condition: true

metaR RTOTALt
is: SBO:0000185
name: RTOTAL transport
product: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110047#

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reversible: true
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000000
modifier: MODEL1310110047#

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_55c42c50_c7b4_4561_916f_255ccc5b6984
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:84532
is: SBO:0000252
name: ACSS1
is: Q9NUB1

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_463527a5_67cd_4012_9f8f_ea5f164b41a8
is: A6H8L5
is encoded by: hsa:3990
name: LIPC
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM hs deg19 l
type: Species
is: CHEBI:17180
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01352
name: heparan sulfate, degradation product 19
initial concentration: 1.0
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
initial amount: NaN

metaM xyl D e
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
boundary condition: false
is: CHEBI:15936
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: aldehydo-D-xylose

http://identifiers.org/biomodels.db/MODEL1310110047#_5a537243_8e7a_4c0f_a75d_054be83fc7e8
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: _AI971036_1_c
is encoded by: hsa:AI971036
has only substance units: false

metaR HDCEAtr
kinetic law: MODEL1310110047#
fast: false
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#

metaR r0246
reactant: MODEL1310110047#
reversible: false
product: MODEL1310110047#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110047#
type: Reaction

metaR FAOXC150m
reactant: MODEL1310110047#
name: Beta oxidation of long chain fatty acid (odd chain)
type: Reaction
reversible: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM ksi pre22 g
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: HMDB00175
type: Species
has only substance units: false
boundary condition: false
is: C00130
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 22
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8095b974_e309_4665_8679_cdddb47fe2e0
constant: false
boundary condition: true
is: Q9NSW9
is encoded by: hsa:6553
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC9A5
is: SBO:0000252

metaM aacoa x
is: HMDB01484
type: Species
is: CHEBI:57286
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
name: acetoacetyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaM CE4876 r
name: delta12-Prostaglandin J2
type: Species
initial amount: NaN
is: CHEBI:57923
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

metaM xyl D l
initial concentration: 1.0
boundary condition: false
is: CHEBI:15936
has only substance units: false
is: SBO:0000247
name: aldehydo-D-xylose
initial amount: NaN
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_bef3ac87_7353_4abe_bdf6_689aee530461
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: _AI971036_1_m
type: Species
initial amount: NaN
is encoded by: hsa:AI971036

http://identifiers.org/biomodels.db/MODEL1310110047#_720cc94b_5af3_489b_9ae8_eadff579f7cc
type: Species
is encoded by: hsa:63917
initial concentration: NaN
name: GALNT11
constant: false
is: SBO:0000252
is: B3KWF4
initial amount: NaN
boundary condition: true
has only substance units: false

metaM 42A3HP24DB c
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
has only substance units: false
constant: false
boundary condition: false
is: HMDB04083
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7956
initial amount: NaN
is: C05645
type: Species

metaR r1375
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Transport reaction
reactant: MODEL1310110047#
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_2f4da127_9a20_4aa2_a035_496d5620c87b
is encoded by: hsa:6472
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: SHMT2
is: B4DJQ3
type: Species
is: SBO:0000252

metaR r2196
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM hmgcoa m
initial amount: NaN
has only substance units: false
type: Species
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
boundary condition: false
is: CHEBI:15467
is: HMDB01375

http://identifiers.org/biomodels.db/MODEL1310110047#_f04d25a8_ef7f_4689_a623_40002c2b281d
has only substance units: false
name: PDE8A
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: H0YMZ7
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110047#_813fd6ad_9af0_4610_82e4_18f6f3888028
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PYCRL
is: Q53H96
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:65263

metaR COAtg
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
name: CoA transport in Golgi via diffusion

http://identifiers.org/biomodels.db/MODEL1310110047#_11e18969_c16d_4c60_9e44_a75b389674d0
boundary condition: true
is encoded by: hsa:8704
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: B4GALT2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_84f3077d_ae0d_4cb5_ab79_47ae4b82f519
initial concentration: NaN
is: Q02218
initial amount: NaN
name: OGDH
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4967

metaR LEUKTRB4t
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: leukotriene B4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110047#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM nrpphrsf e
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB02062
is: SBO:0000247
name: Sulfate derivative of norepinephrine
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: http://identifiers.org/pubchem.compound/123747

metaR PHCDm
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
modifier: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000304
fast: false
type: Reaction

metaM 3hibutcoa m
initial concentration: 1.0
constant: false
name: (S)-3-Hydroxyisobutyryl-CoA
is: CHEBI:28259
has only substance units: false
is: HMDB01052
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
type: Species

metaR r2197
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
fast: false
product: MODEL1310110047#
is described by: ECO:0000000

metaM lnlccoa m
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
constant: false
name: linoleic coenzyme A
has only substance units: false

metaR NACHEX2ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_322ec228_9faf_4360_8e3b_14fd9d30a4d7
constant: false
has only substance units: false
is: Q9UN76
is: SBO:0000252
name: SLC6A14
is encoded by: hsa:11254
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR SPH1Pte
is: SBO:0000185
name: sph1p transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110047#
type: Reaction

metaR FORtr
name: FOR transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110047#
reversible: true
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_6a8a4847_d844_40f3_863c_04eb640dba4e
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:6482
name: ST3GAL1
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_ca3970e9_c26a_41f2_8de1_4e9503e1db49
is: A5PKZ1
name: GALNT5
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11227
constant: false
type: Species

metaR RE1807C
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_b81672d4_42f1_48ac_841a_24282d9a1714
boundary condition: true
initial concentration: NaN
name: SC5DL
type: Species
is encoded by: hsa:6309
is: SBO:0000252
constant: false
has only substance units: false
is: Q6GTM5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_8da8b8f9_5972_4511_bd40_4515451890e0
type: Species
is encoded by: hsa:5244
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ABCB4

metaR r0249
modifier: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110047#
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.12
reversible: true
kinetic law: MODEL1310110047#

metaR CMPSASn
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.7.43
reversible: false
type: Reaction
fast: false
name: CMP sialic acid synthase, nuclear
product: MODEL1310110047#

metaR STRDNCCRNt
product: MODEL1310110047#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
reactant: MODEL1310110047#

metaR BACCLm
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000254
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#

metaM mi4p D c
boundary condition: false
name: 1D-myo-inositol 4-phosphate(2-)
initial concentration: 1.0
is: CHEBI:58469
initial amount: NaN
is: HMDB01313
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
has only substance units: false
type: Species
constant: false
is: SBO:0000247

metaR r1630
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM ascb L e
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
name: L-ascorbate
is: HMDB00044
is: CHEBI:38290
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: SBO:0000247
initial concentration: 1.0

metaM ksii core4 e
is: CHEBI:17268
type: Species
name: keratan sulfate II (core 4-linked)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
is: HMDB00211

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_17fb8ee3_9fef_4343_bc65_e91a9eb12bcc
is: P42765
is encoded by: hsa:10449
constant: false
name: ACAA2
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
type: Species
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
is: CHEBI:26174
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

metaM ppi r
is: HMDB00250
constant: false
name: Diphosphate
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
has only substance units: false
boundary condition: false
is: C00013

metaM ump n
has only substance units: false
boundary condition: false
is: HMDB00288
is: CHEBI:57865
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: UMP(2-)
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaM 4abut m
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
constant: false
is: C00334
is: HMDB00112
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: 4-Aminobutanoate
boundary condition: false
initial concentration: 1.0
is: CHEBI:16865

metaR THRSERNaEx
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185
reactant: MODEL1310110047#
product: MODEL1310110047#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110047#
reversible: false
fast: false
modifier: MODEL1310110047#

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR G14T9g
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110047#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR r2195
is described by: ECO:0000000
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
fast: false
product: MODEL1310110047#
is: SBO:0000185

metaR r1742
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185

metaM nrpphrsf c
type: Species
is: http://identifiers.org/pubchem.compound/123747
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
name: Sulfate derivative of norepinephrine
initial amount: NaN
is: HMDB02062
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: SBO:0000247

metaM 3octdece1coa c
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
type: Species
name: 3-hydroxyoctadecenoylcoa
initial concentration: 1.0
is: HMDB13336

http://identifiers.org/biomodels.db/MODEL1310110047#_2ba9afd3_3be8_4d54_9707_365610abd95c
is: Q9Y2Z9
constant: false
name: COQ6
type: Species
boundary condition: true
is encoded by: hsa:51004
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM etfox m
initial amount: NaN
has only substance units: false
notes: FORMULA: R CHARGE: 0
type: Species
constant: false
is: CHEBI:16469
initial concentration: 1.0
is: SBO:0000247
name: Electron transfer flavoprotein oxidized
is: HMDB00151
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_58f0944e_f4eb_47d2_8dc6_e589032e9ebf
name: DECR2
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:26063
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9NUI1

metaR r0527
is: SBO:0000176
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
product: MODEL1310110047#
is described by: ECO:0000000
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c1d4f97f_5c53_4c0f_8bbe_b854ae9834cc
is: SBO:0000252
is: B3KN25
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CEPT1
is encoded by: hsa:10390
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3377d218_fe4b_4240_b440_d03f19b4b932
initial concentration: NaN
is: SBO:0000252
name: PDE9A
type: Species
constant: false
boundary condition: true
is encoded by: hsa:5152
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_e336c137_307e_4535_9644_c1929a26a62f
has only substance units: false
is: SBO:0000252
name: INPP4A
boundary condition: true
type: Species
is encoded by: hsa:3631
initial amount: NaN
initial concentration: NaN
constant: false

metaR P5CR
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000176
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
type: Reaction
reactant: MODEL1310110047#
name: pyrroline-5-carboxylate reductase

metaM guln r
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB03290
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
has only substance units: false
is: CHEBI:13115
name: L-gulonate

http://identifiers.org/biomodels.db/MODEL1310110047#_a96efd93_6579_4b7f_9ad9_550b2ce14961
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: DGKH
is encoded by: hsa:160851
initial concentration: NaN
is: A8K0I1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_c7205c54_ca82_4715_9309_209b4c1dd3eb
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:8527
initial concentration: NaN
constant: false
is: SBO:0000252
name: DGKD

metaR CREATt4 2 r
kinetic law: MODEL1310110047#
type: Reaction
name: Creatine transport (sodium symport) (2:1)
is: SBO:0000185
reversible: true
is described by: ECO:0000269
product: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR FADH2tru
product: MODEL1310110047#
fast: false
name: FADH2 transporter, endoplasmic reticulum
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000185

metaR PI45P4P
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
type: Reaction

metaR FUMTSULtm
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
name: Fumarate:thiosulfate antiport, mitochondrial
modifier: MODEL1310110047#
is: SBO:0000185

metaM HC00664 c
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: D-tagatofuranose 6-phosphate(2-)
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
is: CHEBI:58695
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_324c3358_6507_42f4_9a34_01f767340df5
type: Species
is: Q9GZV3
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC5A7
has only substance units: false
is encoded by: hsa:60482
boundary condition: true

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM gum e
initial concentration: 1.0
type: Species
is: HMDB00759
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
name: gums
is: http://identifiers.org/pubchem.compound/102468
is: SBO:0000247
is: C02155

metaM 3mlda c
name: 3-Methylimidazoleacetic acid
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/8122
type: Species
has only substance units: false
is: C05828
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial concentration: 1.0
constant: false
is: HMDB02820
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_034b66ec_7f89_45fb_a645_330eee5e0268
is: P04181
name: OAT
boundary condition: true
is encoded by: hsa:4942
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaM ascb L c
is: CHEBI:38290
is: SBO:0000247
type: Species
boundary condition: false
name: L-ascorbate
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
constant: false
is: HMDB00044
has only substance units: false

metaM itacon m
boundary condition: false
constant: false
name: itaconate(2-)
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB02092
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial amount: NaN
is: CHEBI:17240

metaM fol c
initial concentration: 1.0
is: HMDB00121
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
name: Folate
type: Species

metaR r0683
type: Reaction
modifier: MODEL1310110047#
reversible: false
is: SBO:0000176
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110047#
is described by: ECO:0000000

metaR COAtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110047#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110047#
reversible: true
type: Reaction
name: CoA transport in lysosome via diffusion
reactant: MODEL1310110047#

metaM ksii core4 g
has only substance units: false
initial concentration: 1.0
is: CHEBI:16443
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
type: Species
is: HMDB03418
boundary condition: false

metaR EX 3deccrn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_8d488813_a797_43a7_a2df_ea17cc2c83b8
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PLCH2
constant: false
is encoded by: hsa:9651
is: O75038
type: Species
initial concentration: NaN
boundary condition: true

metaR ALR2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is: SBO:0000176
is described by: ECO:0000269
reversible: false
type: Reaction
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110047#
name: aldose reductase (methylglyoxal)

http://identifiers.org/biomodels.db/MODEL1310110047#_65d406dc_fa64_48f0_a7f3_6f588f5f0bee
has only substance units: false
is: Q92521
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: PIGB
constant: false
initial concentration: NaN
is encoded by: hsa:9488

http://identifiers.org/biomodels.db/MODEL1310110047#_d4c93022_9585_49b3_a736_fec55ca4200a
initial concentration: NaN
name: _100128062_1_m
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:100128062
boundary condition: true

metaM ppi n
initial concentration: 1.0
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
boundary condition: false
name: diphosphate(3-)
is: CHEBI:33019
constant: false
is: SBO:0000247
has only substance units: false
type: Species

metaM cl c
name: Chloride
type: Species
notes: FORMULA: Cl CHARGE: -1
is: CHEBI:3966
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00115
boundary condition: false
is: HMDB00492
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_9308b40e_03d3_408e_a3a0_192062914639
name: PIP5K1B
initial concentration: NaN
type: Species
is: O14986
is encoded by: hsa:8395
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_e6cebb95_9448_4531_9079_7a78a3a04e56
is: P35270
constant: false
type: Species
name: SPR
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6697
initial concentration: NaN

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR GLCAASE9ly
fast: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
type: Reaction

metaM amp r
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:456215
boundary condition: false
is: C00020
is: HMDB00045

metaM triodthy c
has only substance units: false
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
boundary condition: false
is: HMDB00265
type: Species
is: CHEBI:18258
initial concentration: 1.0

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM cspg e e
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: HMDB00300
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
type: Species
constant: false
is: CHEBI:17568
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00106

metaR r0686
type: Reaction
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false

metaR G12MT1 U
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110047#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
reversible: false
reactant: MODEL1310110047#
is: SBO:0000176

metaR COAtm
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is described by: ECO:0000269
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
is: SBO:0000185
name: CoA transporter
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_09799693_9f2f_41d4_a7f7_169d9fd0eb1e
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: Q6IBA0
initial concentration: NaN
is encoded by: hsa:4725
name: NDUFS5
is: SBO:0000252
type: Species

metaR ADCim
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
name: Acetoacetate decarboxylation (irreversible), mitochondrial
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_864469d3_feba_4019_9430_94e40dbf9d36
initial concentration: NaN
name: PSAT1
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:29968
constant: false
boundary condition: true
initial amount: NaN

MODEL1310110047#
species: metaM c4crn e
species: metaM prist c
species: metaM Rtotal2 e
species: metaM sebcoa x
species: metaM h2o2 c
species: metaM formcoa c
species: metaM 2oxoadp c
species: metaM HC00718 c
species: metaM m4mpdol U r
species: metaM gly m
species: metaM aprgstrn e
species: metaM 5fthf m
species: metaM retinal c
species: metaM etoh e
species: metaM ksi pre18 g
species: metaM tchola c
species: metaM phytcoa c
species: metaM g1p c
species: metaM 3mlda c
species: metaM CE4792 m
species: metaM 3hodcoa c
species: metaM hexdpencoa x
species: metaM dump n
species: metaM guln c
species: metaM 4hpro LT m
species: metaM citr L m
species: metaM leuktrA4 e
species: metaM hx2coa m
species: metaM pyr c
species: metaM ump e
species: metaM dgcholcoa x
species: metaM ksi deg36 l
species: metaM btn m
species: metaM his L m
species: metaM 7thf e
species: metaM C05965 e
species: metaM CE5132 c
species: metaM apoC Lys c
species: metaM m2mn l
species: metaM ppi n
species: metaM so4 c
species: metaM clpndcoa x
species: metaM vacccrn c
species: metaM adrn c
species: metaM mi3p D c
species: metaM hs deg22 l
species: metaM prpp c
species: metaM dtmp c
species: metaM ump g
species: metaM hs deg17 l
species: metaM arachdcrn c
species: metaM chsterol e
species: metaM glyc c
species: metaM creat c
species: metaM 10fthf c
species: metaM C02528 c
species: metaM ksii core4 deg2 l
species: metaM strdnccrn m
species: metaM hom L e
kind: GRAM
species: metaM c8crn e
species: metaM c51crn c
species: metaM ha deg1 l
species: metaM fuc12gal14acglcgalgluside hs g
stoichiometry: 5.0
species: metaM chol n
species: metaM acgal1p c
species: metaM atp n
species: metaM gthrd m
species: metaM leuleu e
species: metaM tchola x
species: metaM xolest2 hs e
species: metaM amp x
species: metaM dgchol c
species: metaM succoa c
species: metaM glx c
species: metaM g3m8masn r
species: metaM CE5854 e
species: metaM lnlccoa m
species: metaM adp m

http://identifiers.org/biomodels.db/MODEL1310110047#_6761df41_1c79_48c5_b0c6_99c68628a40d
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC25A4
has only substance units: false
is: P12235
is encoded by: hsa:291
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_9b0d86d0_a7e4_452e_962b_de6adbe7e7d6
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: P49914
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10588
name: MTHFS
initial amount: NaN

metaR FAOXTC122m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaR AHEXASEly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176

metaR ALR3
is described by: ECO:0000269
kinetic law: MODEL1310110047#
reversible: false
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: aldose reductase (acetol)
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110047#
type: Reaction
fast: false

metaR FAOXC18C18OHm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR TXASr
reactant: MODEL1310110047#
is described by: ECO:0000134
name: Thromboxane-A synthase
is version of: http://identifiers.org/ec-code/5.3.99.5
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
kinetic law: MODEL1310110047#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110047#
product: MODEL1310110047#

metaM sebacid c
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C10H16O4 CHARGE: -2
initial concentration: 1.0
is: C08277
is: HMDB00792
name: sebacicacid
initial amount: NaN
has only substance units: false

metaM ppi m
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB00250
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
is: CHEBI:33019
initial concentration: 1.0
is: C00013
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_6cca8f52_a4fb_4e99_82af_6e5159df711f
has only substance units: false
name: DPAGT1
type: Species
initial amount: NaN
is encoded by: hsa:1798
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_74f0ef78_515c_484f_ba14_2939de2c8826
initial amount: NaN
name: SLC14A1
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:6563
is: G0W2N5
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_01f4bc51_6c48_4993_b256_b6e27f464a5b
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: ALDH9A1
is encoded by: hsa:223
is: P49189
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR COAtn
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110047#
name: coenzyme A transport, nuclear
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR PPCOAOm
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110047#
is: SBO:0000176
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is described by: ECO:0000269
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD

metaR FBA
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
name: fructose-bisphosphate aldolase
product: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
reactant: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_c8a60c3b_2d21_4e61_a573_6d65749e5d52
initial amount: NaN
type: Species
boundary condition: true
name: HK2
has only substance units: false
is encoded by: hsa:3099
is: SBO:0000252
initial concentration: NaN
constant: false
is: P52789

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM zymstnl r
name: 5alpha-cholest-8-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
constant: false
has only substance units: false
boundary condition: false
is: HMDB06841
is: CHEBI:16608
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_9c534457_7c05_4e30_9e79_d7087082116a
is: SBO:0000252
constant: false
has only substance units: false
is: Q7Z4L0
is encoded by: hsa:341947
boundary condition: true
name: COX8C
initial concentration: NaN
type: Species
initial amount: NaN

metaR RE0689E
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE0689
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_2682b4ef_89ab_4053_b4cb_92cfd4e64b4e
initial concentration: NaN
name: _R39999_1_c
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:R39999
has only substance units: false
is: SBO:0000252
type: Species

metaM CE5116 x
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA
is: CHEBI:57923
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaR r2309
is: SBO:0000185
product: MODEL1310110047#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR r0680
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137

http://identifiers.org/biomodels.db/MODEL1310110047#_04efe38d_7e83_4fbe_a939_e5cd8fe7f040
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1544
constant: false
type: Species
is: P05177
name: CYP1A2
has only substance units: false

metaM ksii core4 l
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
type: Species
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
is: CHEBI:16443
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB03418
initial amount: NaN

metaR UMPKn
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is described by: ECO:0000269
name: UMP kinase, nuclear
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_963544d1_63d7_4f4a_9dba_01829eba133e
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:38
type: Species
has only substance units: false
initial concentration: NaN
is: P24752
name: ACAT1

metaM triodthy e
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
type: Species
is: HMDB00265
boundary condition: false
is: CHEBI:18258

metaR HEXDIACTD
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM pmtcrn x
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false
is: HMDB00222
constant: false
boundary condition: false
is: CHEBI:17490
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: L-palmitoylcarnitine

metaR PMEVKc
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.2
modifier: MODEL1310110047#
reversible: false
is: SBO:0000176
reactant: MODEL1310110047#
type: Reaction
fast: false
name: phosphomevalonate kinase, cytosol
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
kinetic law: MODEL1310110047#

metaM cl e
initial concentration: 1.0
boundary condition: false
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
name: Chloride
is: HMDB00492
constant: false
has only substance units: false
is: C00115
is: SBO:0000247
type: Species

metaM formcoa c
initial concentration: 1.0
has only substance units: false
is: CHEBI:57376
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
name: formyl-CoA(4-)
is: SBO:0000247
constant: false
is: HMDB03419
type: Species
boundary condition: false
initial amount: NaN

metaM HC01403 m
boundary condition: false
is: CHEBI:28325
constant: false
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264

http://identifiers.org/biomodels.db/MODEL1310110047#_bbe73d82_9c9d_4ba8_af93_41c9fbe20c07
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: MCCC2
is: SBO:0000252
is encoded by: hsa:64087
boundary condition: true
is: Q9HCC0
type: Species

metaR TYRCBOX
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.1.1.28
fast: false
name: L-Tyrosine carboxy-lyase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM cys L c
name: L-cysteine
boundary condition: false
initial amount: NaN
is: CHEBI:17561
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
type: Species
is: HMDB00574
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_7d03d0f6_6a1d_4294_8ab7_2f6df472271e
name: B3GNT4
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9C0J1
is encoded by: hsa:79369
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_2a941be1_2fd7_44ff_987b_c7dc39955bfd
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: PDE9A
initial amount: NaN
is encoded by: hsa:5152
boundary condition: true

metaM c226coa x
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_0e837ebf_dc50_4575_a6ca_8541a8499be9
is encoded by: hsa:9563
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: O95479
is: SBO:0000252
initial amount: NaN
name: H6PD
type: Species

metaR S6T15g
kinetic law: MODEL1310110047#
is: SBO:0000176
fast: false
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.8.2.21
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
modifier: MODEL1310110047#

metaR PHETHPTOX2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
fast: false
reactant: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.14.16.1

metaR r2308
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110047#

metaR ALDD2y
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110047#
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is described by: ECO:0000000
fast: false

metaR ASNNm
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
fast: false
reactant: MODEL1310110047#
name: L-asparaginase (mitochondrial)
type: Reaction
reversible: false
kinetic law: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.1
product: MODEL1310110047#
modifier: MODEL1310110047#

metaR COAtp
product: MODEL1310110047#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
name: coenzyme A transport, peroxisomal
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000185

metaM ksi deg21 l
initial amount: NaN
name: keratan sulfate I, degradation product 21
is: CHEBI:12936
is: HMDB00143
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
initial concentration: 1.0

metaM subeac c
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00893
has only substance units: false
name: suberic acid
type: Species
notes: FORMULA: C8H12O4 CHARGE: -2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f475e03b_1e4a_4fcd_85ab_ede2c5c17e31
boundary condition: true
initial concentration: NaN
name: NOS1
is: SBO:0000252
has only substance units: false
constant: false
is: B4DG68
initial amount: NaN
is encoded by: hsa:4842
type: Species

metaM lthstrl r
name: 5alpha-cholest-7-en-3beta-ol
initial concentration: 1.0
boundary condition: false
is: HMDB01170
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
type: Species
is: CHEBI:17168

metaM 2mop c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: HMDB01172
boundary condition: false
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
is: CHEBI:57700

metaR RE1517M
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
name: RE1517
product: MODEL1310110047#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR r0242
reversible: true
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
is: SBO:0000176
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:

metaR LTA4H
modifier: MODEL1310110047#
name: Leukotriene A-4 hydrolase
is version of: http://identifiers.org/ec-code/3.3.2.6
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_c4aceb2e_f11e_4da7_a43b_711da98a7574
initial concentration: NaN
name: MAN2A2
initial amount: NaN
boundary condition: true
is: Q9P1E4
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4122

metaM ala D x
is: HMDB01310
is: CHEBI:15570
boundary condition: false
name: D-alanine
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
initial amount: NaN
has only substance units: false

metaR r2416
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:
product: MODEL1310110047#
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: false

metaR ALDD2x
reversible: false
product: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
name: aldehyde dehydrogenase (acetaldehyde, NAD)
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM ksi pre14 g
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
has only substance units: false
initial amount: NaN
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 14
initial concentration: 1.0
is: CHEBI:28067
is: SBO:0000247
constant: false
type: Species

metaR FAOXC160
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
type: Reaction

metaM q10 m
is: SBO:0000247
has only substance units: false
name: ubiquinone-10
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: HMDB01072
constant: false
is: CHEBI:46245
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_68d2f4d7_b641_483f_9ee6_8ff0500030b3
is encoded by: hsa:221823
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PRPS1L1
is: P21108
has only substance units: false
constant: false

metaR r1738
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
fast: false
reversible: false
modifier: MODEL1310110047#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_7f46ec25_310a_455b_a4b9_5471d0b4124c
initial amount: NaN
name: GALK2
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2585
has only substance units: false

metaR NDP10ex
is described by: ECO:0000269
reactant: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
name: nucleoside-diphosphatase (IDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_1258d982_b42e_45a3_a4f8_25d064267e72
is encoded by: hsa:4668
initial concentration: NaN
boundary condition: true
is: P17050
initial amount: NaN
name: NAGA
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaM nadh x
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
initial amount: NaN
has only substance units: false
is: C00004
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57945
type: Species
name: Nicotinamide adenine dinucleotide - reduced
boundary condition: false
constant: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR S6T9g
type: Reaction
fast: false
reversible: false
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110047#

metaM n2m2nmn l
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: HMDB00939
is: CHEBI:16680
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3d0cc4a6_923b_487f_972d_9654eb107be1
is: P04062
name: GBA
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2629
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_df376580_1177_4580_aa3c_a2ad557b5cb6
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q8NCI4
is encoded by: hsa:54872
name: PIGG
initial amount: NaN

metaM amp m
is: HMDB00045
initial concentration: 1.0
constant: false
is: CHEBI:456215
has only substance units: false
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
is: SBO:0000247
name: AMP(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_bdc3c821_ec57_4017_a2d8_bd119d394689
boundary condition: true
is: SBO:0000252
name: PIGH
is encoded by: hsa:5283
type: Species
initial concentration: NaN
constant: false
is: Q14442
initial amount: NaN
has only substance units: false

metaR FAOXC240200x
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:0 -> c20:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
product: MODEL1310110047#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaR SEBCOACROT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR UGCG
name: Ceramide glucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.80
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110047#
fast: false
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
is described by: ECO:0000000

metaM 4izp c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
constant: false
is: CHEBI:57255
initial concentration: 1.0
type: Species
name: 4-Imidazolone-5-propanoate
has only substance units: false
initial amount: NaN
is: HMDB01014

metaR COAtr
product: MODEL1310110047#
reversible: true
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
fast: false
name: COA transporter, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_7970adc9_9f56_4c13_a0f2_7eebe174ac7d
initial concentration: NaN
type: Species
has only substance units: false
is: Q96RN1
is: SBO:0000252
name: SLC26A8
boundary condition: true
initial amount: NaN
is encoded by: hsa:116369
constant: false

metaR r1627
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_c4e75cf0_901d_4258_854b_0f15a71aff24
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:728226
boundary condition: true
type: Species
name: _728226_1_m
is: SBO:0000252
initial amount: NaN

metaR HAS2
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reversible: false
name: hyaluronan synthase
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.212
is: SBO:0000185
modifier: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_58b05b94_0501_4676_b089_2131ae56a460
boundary condition: true
name: B3GALNT1
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q8TDY1
is encoded by: hsa:8706
constant: false
initial amount: NaN

MODEL1310110047
species: metaM CE5116 x
species: metaM orn c
reaction: metaR PROSTGE2t
species: metaM tdcoa m
reaction: metaR r1658
reaction: metaR S6T12g
reaction: metaR EX 7thf LPAREN e RPAREN
species: metaM bhb e
reaction: metaR B3GNT32g
reaction: metaR FAOXC141C121m
species: metaM h l
species: metaM acrn r
reaction: metaR r1177
reaction: metaR FUMTSULtm
reaction: metaR r1301
reaction: metaR SPHK21c
reaction: metaR EICOSTETCPT2
reaction: metaR ARACHCPT2
reaction: metaR LPS3e
species: metaM udpgal e
reaction: metaR RE0691C
species: metaM h2o e
reaction: metaR LNELDCCPT1
reaction: metaR HMGCOARc
reaction: metaR DHCHOLESTANATEtm
species: metaM tdec4ecoa m
species: metaM ptdcacoa m
species: metaM acgam l
species: metaM dhap m
reaction: metaR SO4tl
species: metaM 3ttetddcoacrn e
species: metaM glac c
reaction: metaR r2098
reaction: metaR GLNCYSNaEx
species: metaM cmpacna c
species: metaM dpcoa l
species: metaM mercppyr c
reaction: metaR S6TASE25ly
species: metaM acgam1p c
species: metaM m6mpdol U r
reaction: metaR ACHtn
species: metaM dolglcp U c
reaction: metaR IDOAASE3ly
species: metaM retn r
reaction: metaR FCLTm
reaction: metaR C161CPT1
species: metaM 11 cis retfa e
reaction: metaR PTCRTD
reaction: metaR r0463
species: metaM cgly e
reaction: metaR EX 3hdececrn
species: metaM acac c
species: metaM galgalthcrm hs g
reaction: metaR r0267
reaction: metaR r2109
reaction: metaR HPDCACRNCPT1
species: metaM lnlncacrn c
species: metaM ha pre1 e
reaction: metaR r2357
reaction: metaR TIGCRNe
reaction: metaR C142ACBP
species: metaM arachd x
reaction: metaR NACHEX23ly
species: metaM dcdp c
species: metaM 4mop e
species: metaM leuktrC4 e
species: metaM ksii core2 pre8 g
reaction: metaR GLYBtm
reaction: metaR GACPAILter
species: metaM tddedicoa m
reaction: metaR r0394
reaction: metaR 4NPHSULT
reaction: metaR C9BRxtc
species: metaM leuleu c
species: metaM ksi deg34 l
reaction: metaR LNLNCACPT1
species: metaM h2o m
reaction: metaR EX c81crn
reaction: metaR r0193
species: metaM malthx e

http://identifiers.org/biomodels.db/MODEL1310110047#_5e8769cd_272d_4180_a732_13ed71a43ec9
is: Q53Y83
has only substance units: false
name: GLA
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2717

metaM 3octdece1coa m
initial amount: NaN
name: 3-hydroxyoctadecenoylcoa
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species

metaM amp x
is: CHEBI:456215
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
type: Species
initial amount: NaN
name: AMP
is: HMDB00045
is: SBO:0000247
boundary condition: false
is: C00020
has only substance units: false

metaM cspg e l
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: CHEBI:36005
is: HMDB02183

metaR DOLGPP Uer
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110047#
type: Reaction
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM trp L c
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16828
name: L-tryptophan
is: HMDB00929

metaM ribflv c
is: CHEBI:3554
initial concentration: 1.0
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: SBO:0000247
is: C00255
boundary condition: false
constant: false
is: HMDB00244
type: Species
name: Riboflavin
initial amount: NaN
has only substance units: false

metaR r1628
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR A4GALTg
is version of: http://identifiers.org/ec-code/2.4.1.228
fast: false
name: Lactosylceramide 4-alpha-galactosyltransferase
reactant: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
modifier: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110047#
reversible: false

metaM glutcoa c
has only substance units: false
constant: false
name: glutaryl-CoA(5-)
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01339
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1

metaR ADNCYC
name: adenylate cyclase
is version of: http://identifiers.org/ec-code/4.6.1.1
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
reversible: false
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176

metaM odecrn c
is: CHEBI:57394
constant: false
has only substance units: false
is: HMDB01114
is: C00412
initial concentration: 1.0
name: octadecenoyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_8af3b5b5_d79b_44d9_850e_5789ddc269aa
constant: false
initial concentration: NaN
type: Species
is: Q16760
is encoded by: hsa:8527
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: DGKD

metaR r0130
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

metaR BILDGLCURt
is described by: ECO:0000269
fast: false
modifier: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
type: Reaction
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ

metaR r1629
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_9125211e_67d3_427d_8386_23666ae4c2bf
is encoded by: hsa:5279
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: PIGC

metaM hdcecrn m
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
is: HMDB00222
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Hexadecenoyl carnitine

metaR TAGt
fast: false
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: triacylglycerol transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_438060ae_017c_4ddc_88c2_c9b7def6125c
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9Y633
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5136
name: PDE1A

metaM pmtcrn r
initial amount: NaN
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: L-palmitoylcarnitine
is: SBO:0000247
type: Species
is: HMDB00222

metaR MAL Ltx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
name: Transport reaction for malate
reactant: MODEL1310110047#
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110047#
fast: false

metaR VITD3t2
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Vitamin D3 uptake
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
is: SBO:0000185
product: MODEL1310110047#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_4025c6d6_9428_47e1_bea9_d9f7838fd5f7
boundary condition: true
has only substance units: false
is encoded by: hsa:5244
initial concentration: NaN
is: SBO:0000252
type: Species
is: P21439
constant: false
name: ABCB4
initial amount: NaN

metaM gbside hs g
initial amount: NaN
is: CHEBI:18259
is: SBO:0000247
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
boundary condition: false
name: globoside
type: Species
initial concentration: 1.0
constant: false
has only substance units: false

metaM trp L e
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
has only substance units: false
is: CHEBI:16828
name: L-tryptophan
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00929
boundary condition: false
type: Species

metaR PMANM
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.4.2.2
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.4.2.8
name: phosphomannomutase
fast: false
reversible: true

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM 3mgcoa m
boundary condition: false
is: CHEBI:57346
constant: false
is: HMDB01057
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
name: trans-3-methylglutaconyl-CoA(5-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM 2octpencoa m
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
name: 2,6,9,12,15-octadecapentenoylcoa
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H56N7O17P3S CHARGE: -4

metaM ribflv e
has only substance units: false
is: CHEBI:3554
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: C00255
constant: false
boundary condition: false
is: HMDB00244
initial amount: NaN
type: Species
name: Riboflavin

metaR RE3347C
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
name: RE3347
product: MODEL1310110047#
is: SBO:0000176
type: Reaction

metaM ppi e
is: CHEBI:33019
constant: false
initial concentration: 1.0
is: HMDB00250
has only substance units: false
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Diphosphate

metaR OIVD2m
reversible: false
product: MODEL1310110047#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.168
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
reactant: MODEL1310110047#

metaM hxcoa x
is: SBO:0000247
is: HMDB00705
constant: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
has only substance units: false
name: Hexanoyl-CoA (n-C6:0CoA)
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_398c754e_9911_4630_9ed6_3744ee0539aa
initial concentration: NaN
is: Q8WUX1
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC38A5
is: SBO:0000252
constant: false
is encoded by: hsa:92745
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_bcbd60b7_2b0c_4d50_8f03_a24f3b152bec
has only substance units: false
is: SBO:0000252
constant: false
is: O43280
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: TREH
is encoded by: hsa:11181
type: Species

metaM cys L e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:17561
initial amount: NaN
name: L-cysteine
is: HMDB00574
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
boundary condition: false

metaM leuktrB4 c
initial amount: NaN
boundary condition: false
name: leukotriene B4(1-)
type: Species
is: HMDB01085
constant: false
is: SBO:0000247
is: CHEBI:57461
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_514109bd_735c_443e_a6fa_2b27052f1ad5
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10999
is: Q6P1M0
initial concentration: NaN
type: Species
name: SLC27A4
boundary condition: true
constant: false
has only substance units: false

metaR NODe
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000185
name: NODe
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110047#

metaM HC02208 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
boundary condition: false
constant: false
name: prostaglandin-d1
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27696
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_94f35ad0_dc24_4e38_bae7_827e12603a86
is encoded by: hsa:7991
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is: SBO:0000297
initial amount: NaN
boundary condition: true

metaR CLOHtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
product: MODEL1310110047#
name: chloride transport via hydroxide countertransport (2:1)
reactant: MODEL1310110047#
type: Reaction
reversible: false
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000185
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_63496e15_8d22_4204_8cad_16e9152ab3f8
constant: false
is encoded by: hsa:2348
has only substance units: false
boundary condition: true
name: FOLR1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR RE1898C
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: RE1898
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110047#

metaR r0688
is described by: ECO:0000000
reactant: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110047#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
modifier: MODEL1310110047#

metaR GALASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110047#
name: beta-galactosidase, lysosomal
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_a8181911_62a7_46b9_866a_ff3a1d9b579e
is encoded by: hsa:2182
is: SBO:0000252
type: Species
constant: false
is: Q5JWV8
name: ACSL4
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM ppi c
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00250
boundary condition: false
name: Diphosphate
type: Species
is: C00013
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3
initial concentration: 1.0
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110047#_20c7620d_aa69_4392_ac05_3dec83672f0d
initial amount: NaN
type: Species
name: HK3
initial concentration: NaN
has only substance units: false
constant: false
is: P52790
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3101

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_8440e5ba_1de3_475b_bb45_cb801bf85d2f
is encoded by: hsa:6584
has only substance units: false
is: O76082
constant: false
is: SBO:0000252
boundary condition: true
name: SLC22A5
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_94c22e63_521e_41ca_b7cd_75c0ebda9781
constant: false
has only substance units: false
is encoded by: hsa:5294
type: Species
name: PIK3CG
boundary condition: true
is: SBO:0000252
is: P48736
initial amount: NaN
initial concentration: NaN

metaM leuktrB4 e
is: CHEBI:57461
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
name: leukotriene B4(1-)
is: HMDB01085
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_8084e6c5_e837_4626_8adf_affd09109351
constant: false
name: ALAS2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:212
boundary condition: true
type: Species
initial concentration: NaN
is: Q5JZF5

metaM gbside hs l
is: SBO:0000247
type: Species
is: CHEBI:18259
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial concentration: 1.0
initial amount: NaN
name: globoside

metaR MECOALm
is described by: ECO:0000212
reversible: true
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
type: Reaction
is: SBO:0000176
name: mesaconate--CoA ligase (ADP-forming), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110047#_d62afcc8_3efb_4489_bec8_fe8475ea3e74
name: _8781_1_c
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:8781
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM succ x
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
is: CHEBI:30031
initial amount: NaN
name: Succinate
has only substance units: false
initial concentration: 1.0
type: Species
is: C00042
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_25b659e8_2661_4bee_bac0_673d2646f7ae
type: Species
boundary condition: true
initial concentration: NaN
name: ALDH3B1
is encoded by: hsa:221
constant: false
is: SBO:0000252
has only substance units: false
is: P43353
initial amount: NaN

metaM C05280 m
name: cis,cis-3,6-Dodecadienoyl-CoA
boundary condition: false
is: CHEBI:28002
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
constant: false
is: SBO:0000247
is: HMDB03952

http://identifiers.org/biomodels.db/MODEL1310110047#_e482d531_ebe7_437e_830e_bc6a2709f7a6
name: _AU149534_1_c
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AU149534
initial amount: NaN

metaM nadh r
boundary condition: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
has only substance units: false
type: Species
constant: false
is: HMDB01487
initial amount: NaN
is: SBO:0000247
is: CHEBI:57945
initial concentration: 1.0
name: NADH(2-)

http://identifiers.org/biomodels.db/MODEL1310110047#_1e050843_1efc_4dd1_b1c9_2d1267fd28fc
has part: P38117
name: ETFA:ETFB
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:2109
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_1315e41e_18bb_44be_93db_4fab4de3c217
is encoded by: hsa:218
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P30838
name: ALDH3A1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_fc3d7766_48bd_4f5a_8e06_23f897141193
is: P41222
is: SBO:0000252
constant: false
is encoded by: hsa:5730
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PTGDS

http://identifiers.org/biomodels.db/MODEL1310110047#_02b61be1_4b4b_4032_b701_c439ba6b66ff
is encoded by: hsa:51079
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: Q9P0J0
initial amount: NaN
has only substance units: false
name: NDUFA13

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR DPCOAtl
is: SBO:0000185
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
name: dephospho-CoA transport from lysosome via diffusion

metaR BETALDHxm
is described by: ECO:0000000
reactant: MODEL1310110047#
type: Reaction
name: betaine-aldehyde dehydrogenase, mitochondrial
kinetic law: MODEL1310110047#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
reversible: false
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_9ab872f1_6bc4_4aa1_9a86_f8ed2d48d735
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6534
name: SLC6A7
type: Species
boundary condition: true
is: Q99884
is: SBO:0000252

metaM chlstol r
is: HMDB06842
initial amount: NaN
is: CHEBI:16290
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
has only substance units: false

metaM g3m8masn r
boundary condition: false
is: C05873
constant: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C88H147N2O70X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110047#_fc80bfae_c8d9_47ba_8218_1510d0efeb4b
boundary condition: true
type: Species
is encoded by: hsa:158
initial amount: NaN
name: ADSL
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P30566

metaM pmtcrn m
is: SBO:0000247
has only substance units: false
is: HMDB00222
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
name: L-palmitoylcarnitine
constant: false
is: CHEBI:17490

http://identifiers.org/biomodels.db/MODEL1310110047#_5374430e_5c1b_4966_9130_9577a459bace
initial concentration: NaN
is: P56181
boundary condition: true
name: NDUFV3
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:4731
has only substance units: false

metaR r0960
type: Reaction
product: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reactant: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:

metaR NDPK10
name: nucleoside-diphosphate kinase (ATP:dIDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
reversible: true
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
is described by: ECO:0000134

metaM lcts e
name: Lactose
is: HMDB00186
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: C00243
initial concentration: 1.0
has only substance units: false
is: CHEBI:17716
constant: false
is: SBO:0000247
boundary condition: false
type: Species

metaM hs deg16 l
is: HMDB02704
initial concentration: 1.0
is: CHEBI:21338
boundary condition: false
has only substance units: false
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
constant: false
name: heparan sulfate, degradation product 16
is: SBO:0000247
type: Species
initial amount: NaN

metaM 3mlda e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
boundary condition: false
is: HMDB02820
is: http://identifiers.org/pubchem.compound/8122
constant: false
type: Species
name: 3-Methylimidazoleacetic acid
initial concentration: 1.0
is: C05828
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_a90858b6_63ac_4b84_a4d1_f9d823f83795
type: Species
name: GPT
constant: false
is encoded by: hsa:2875
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P24298

metaM 2mop m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57700
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
name: 2-methyl-3-oxopropanoate
has only substance units: false
is: HMDB01172

metaR FAOXC163GC142m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR S3TASE1ly
kinetic law: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110047#
name: N-acetylglucosamine-3-sulfatase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110047#_bf7cbc8c_3d49_4619_bd06_2cf716d2ebec
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:3420
boundary condition: true
name: IDH3A:IDH3B:IDH3G
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaM 3hddcoa c
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00623
initial concentration: 1.0
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false

metaR MI1PP
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
name: myo-inositol 1-phosphatase
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000176

metaR r1626
reversible: true
product: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_570558dc_cfd1_45ca_98bd_06ef2fb0992b
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:51703
boundary condition: true
is: Q9ULC5
name: ACSL5
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_0d353177_c9a2_442d_96c5_726cb0edba87
boundary condition: true
constant: false
is encoded by: hsa:875
name: CBS
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q9NTF0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_28902dc8_0397_4184_b5c8_1f382e654046
is encoded by: hsa:197257
constant: false
initial concentration: NaN
is: Q86WU2
boundary condition: true
name: LDHD
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_cc77f4c5_fa36_4cf3_bbb2_74e3cb0c55ce
initial concentration: NaN
name: PPA2
has only substance units: false
boundary condition: true
is: SBO:0000252
is: F8WDN9
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:27068

metaR r0839
reversible: true
fast: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
name: Postulated transport reaction
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.1.70

http://identifiers.org/biomodels.db/MODEL1310110047#_68d5bb9d_87f8_49d8_9e71_6511e5528afd
name: CDIPT
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10423
initial amount: NaN
is: O14735
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaM octa e
has only substance units: false
boundary condition: false
name: octanoate (n-C8:0)
is: SBO:0000247
initial concentration: 1.0
is: HMDB00482
is: CHEBI:25646
initial amount: NaN
notes: FORMULA: C8H15O2 CHARGE: -1
is: C06423
type: Species
constant: false

metaR r0944
name: Active transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
kinetic law: MODEL1310110047#

metaR r1771
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM ksi deg14 l
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate I, degradation product 14
is: HMDB00143
is: SBO:0000247

metaR PFK
modifier: MODEL1310110047#
name: phosphofructokinase
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110047#
fast: false
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.11
is: SBO:0000176

metaR 34HPLFM
fast: false
product: MODEL1310110047#
is: SBO:0000176
reversible: false
reactant: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
type: Reaction
name: 3-(4-hydroxyphenyl-)lactate formation

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110047#
is: SBO:0000185
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_f9e3756b_c78d_4da8_873f_ce8c627ce870
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O14495
constant: false
type: Species
name: PPAP2B
boundary condition: true
is encoded by: hsa:8613
has only substance units: false

metaM dmpp x
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01120
constant: false
is: CHEBI:57623
name: prenyl diphosphate(3-)
is: SBO:0000247
initial concentration: 1.0

metaM 4mop m
is: HMDB00695
is: SBO:0000247
is: CHEBI:17865
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
boundary condition: false
initial amount: NaN

metaM gbside hs c
is: SBO:0000247
is: CHEBI:18259
boundary condition: false
constant: false
initial concentration: 1.0
name: globoside
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0

metaR DOLGLCP Uter
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
is: SBO:0000185
kinetic law: MODEL1310110047#
reversible: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110047#
fast: false
type: Reaction
is described by: ECO:0000000

metaR GK1
reversible: true
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.8

http://identifiers.org/biomodels.db/MODEL1310110047#_e2da851b_07d6_4c08_87a0_89d89051566d
boundary condition: true
type: Species
has only substance units: false
name: _AI348006_1_c
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI348006

metaM doco13ecoa x
name: 13-docosenoylcoa
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892791
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

metaM CE4872 m
initial amount: NaN
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: CHEBI:15748
is: HMDB00127

metaM glc D r
name: D-glucose
initial concentration: 1.0
constant: false
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:4167
boundary condition: false

metaR ETOHtx
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110047#
name: ethanol reversible peroxisomal transport
fast: false
is: SBO:0000185
reactant: MODEL1310110047#
type: Reaction
reversible: true
is described by: ECO:0000000

metaM h2o2 m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB03125
constant: false
name: Hydrogen peroxide
is: CHEBI:16240
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_92646fae_169c_4132_8bd3_13d36dbdc0b9
is: SBO:0000252
initial concentration: NaN
is: Q6UWQ5
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: LYZL1
has only substance units: false
is encoded by: hsa:84569

metaR r1624
is: SBO:0000185
product: MODEL1310110047#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
reversible: true

metaM dgdp c
is: HMDB00960
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: dGDP
is: C00361
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: CHEBI:58595
initial amount: NaN
type: Species

metaR DNDPt9m
name: dADP transport via dTDP antiport
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_d8008f09_5dbb_4722_9c13_71538f0a05bb
is encoded by: hsa:6799
constant: false
is: SBO:0000252
name: SULT1A2
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

metaM HC01397 x
type: Species
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
initial amount: NaN
name: (S)-3-Hydroxyhexadecanoyl-CoA

metaR C4OHc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxybytyryl carnitinec
type: Reaction

metaR RE1447N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
is: SBO:0000176
fast: false
product: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_c2dc3cb7_2ca5_4924_b8cc_6eb2e2284abe
is encoded by: hsa:8703
has only substance units: false
constant: false
name: B4GALT3
type: Species
initial amount: NaN
is: A8K5Z0
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r0942
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110047#
reversible: true
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110047#

metaR FAOXC221C201x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_e0da2d0e_c1d1_435e_8293_f60759829f9e
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q5FWE9
is encoded by: hsa:134526
name: ACOT12

http://identifiers.org/biomodels.db/MODEL1310110047#_ebf3be82_54b7_46a8_8798_cea06ab3cbf3
boundary condition: true
type: Species
initial concentration: NaN
name: SLC4A2
is: SBO:0000252
is: F8W682
initial amount: NaN
constant: false
is encoded by: hsa:6522
has only substance units: false

metaM dlnlcgcoa m
name: dihomo-gamma-linolenyl coenzyme A
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false
is: CHEBI:27979
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR GLNASNNaEx
modifier: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110047#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_6d1606a9_1289_49bc_aae4_fe164c2ec3bd
is encoded by: hsa:2651
type: Species
name: GCNT2
initial concentration: NaN
initial amount: NaN
is: Q08M29
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR RE1447M
name: RE1447
modifier: MODEL1310110047#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41

metaM gbside hs e
type: Species
is: SBO:0000247
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:18259
initial concentration: 1.0

metaR FAOXC161C161OHm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaM dhlam m
name: dihydrolipoamide
initial concentration: 1.0
is: CHEBI:17694
is: HMDB00985
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
constant: false
type: Species
initial amount: NaN

metaR r0838
kinetic law: MODEL1310110047#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
modifier: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110047#
name: Free diffusion
fast: false
reactant: MODEL1310110047#

metaR DCYTD
name: deoxycytidine deaminase
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.5
modifier: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_13276280_4ad2_4b2d_adbe_4ec9fa3c46ec
is encoded by: hsa:29085
initial amount: NaN
initial concentration: NaN
is: Q9P019
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PHPT1
constant: false

metaR DGK1
fast: false
is: SBO:0000176
name: deoxyguanylate kinase (dGMP:ATP)
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#

metaR FCOAH
name: formyl coa hydrolase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
fast: false
reversible: false
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000

metaR FAOXTC182TC162m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaM ksi pre34 g
constant: false
initial amount: NaN
is: CHEBI:58053
boundary condition: false
is: C00130
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 34
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: HMDB00175
type: Species
is: SBO:0000247
has only substance units: false

metaM 34hpp m
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:36242
is: HMDB00707
type: Species
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate

metaM dmhptcrn e
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial concentration: 1.0
has only substance units: false
name: 2,6 dimethylheptanoyl carnitine
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB06320
initial amount: NaN
constant: false

metaR FAOXC16BRx
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR RTOTAL2FATPc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR r0940
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
name: Free diffusion
is: SBO:0000185
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#

metaR S6TASE14ly
type: Reaction
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
product: MODEL1310110047#
modifier: MODEL1310110047#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110047#
fast: false
reversible: true

metaR r1622
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110047#
reactant: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM s2l2n2m2mn l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00573
type: Species
has only substance units: false
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: CHEBI:30825
is: SBO:0000247
constant: false

metaR FACOAL160i
is described by: ECO:0000269
name: C160 fatty acid activation
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_719a2730_45d4_4803_b6fb_c7e9dd711864
is: Q9NPB1
constant: false
is encoded by: hsa:56953
has only substance units: false
type: Species
is: SBO:0000252
name: NT5M
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR METAT
is version of: http://identifiers.org/ec-code/2.5.1.6
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110047#
type: Reaction
name: methionine adenosyltransferase

metaM hdcecrn c
name: Hexadecenoyl carnitine
is: HMDB00222
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_5261a203_5ac7_4860_bcc6_16f43ecbee19
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: GLS2
is: Q9UI32
boundary condition: true
initial amount: NaN
is encoded by: hsa:27165

metaR RE2349C
type: Reaction
name: RE2349
reversible: true
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is: SBO:0000176
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
kinetic law: MODEL1310110047#
is: SBO:0000185
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false

metaM h2o2 n
constant: false
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03125
has only substance units: false
type: Species
name: hydrogen peroxide

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM Rtotal2coa c
is: CHEBI:16199
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00086
type: Species
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: HMDB00294
constant: false
is: SBO:0000247
name: R total 2 coenzyme A

metaR 4HBZCOAFm
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false
name: 4-hydroxybenzoyl-CoA formation
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction

metaR r1621
product: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0941
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reversible: true
name: Free diffusion

metaM dolglcp U c
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15812
type: Species
has only substance units: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
is: SBO:0000247

metaM dec47dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
name: 4,7-decadienoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_42c1f3b9_7f85_466d_a524_4cf93311a2fb
is encoded by: hsa:55568
has only substance units: false
boundary condition: true
name: GALNT10
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaM arachd r
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01043
initial amount: NaN
boundary condition: false
has only substance units: false

metaM nadh m
constant: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
type: Species
is: HMDB01487
boundary condition: false
initial concentration: 1.0
is: CHEBI:57945

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
boundary condition: false
is: SBO:0000247
is: CHEBI:26174
initial amount: NaN
has only substance units: false
constant: false
name: nLc7Cer
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_9fca92c2_a6dd_4f40_9127_2198f3f97825
has only substance units: false
initial amount: NaN
constant: false
is: Q9BY49
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:55825
name: PECR

metaM glyclt x
is: HMDB00115
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:29805
name: glycolate
type: Species
initial concentration: 1.0
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
constant: false
initial amount: NaN

metaM octdececrn c
notes: FORMULA: C25H47NO4 CHARGE: 0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB06351

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
reversible: false
name: Beta oxidation fatty acid
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR FAOXC11
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110047#
reversible: false

W3 CDTF: Thu Aug 30 15:48:25 BST 2012

metaM dmhptcrn c
initial concentration: 1.0
type: Species
is: HMDB06320
name: 2,6 dimethylheptanoyl carnitine
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial amount: NaN

metaM n2m2mn l
is: HMDB00939
boundary condition: false
is: CHEBI:16680
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C42H71N3O31 CHARGE: 0
constant: false
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)

metaR RE3524R
reactant: MODEL1310110047#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: RE3524
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
fast: false
product: MODEL1310110047#

metaR r1773
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR r1620
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110047#

metaM octa c
type: Species
is: SBO:0000247
constant: false
name: octanoate (n-C8:0)
notes: FORMULA: C8H15O2 CHARGE: -1
is: HMDB00482
initial amount: NaN
is: C06423
is: CHEBI:25646
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_e4688ec7_0cfe_455c_b698_58a971d590d2
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: Q92781
is encoded by: hsa:5959
name: RDH5

http://identifiers.org/biomodels.db/MODEL1310110047#_0caea373_59f3_4fd5_997d_9360b9ddc0b3
type: Species
initial concentration: NaN
is encoded by: hsa:AL038231
constant: false
boundary condition: true
name: _AL038231_1_c
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_2245485d_8a76_4f98_993b_b5fc8d37d9fe
has part: Q9NZL9
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: MAT2B:MAT2A
is encoded by: hsa:27430
initial concentration: NaN
is: SBO:0000297

metaM dcholcoa r
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
boundary condition: false
is: HMDB06292
initial concentration: 1.0
type: Species

W3 CDTF: Thu Aug 30 15:48:25 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110047#
is: SBO:0000185
name: blood group intracellular transport

metaM 6hoxmelatn c
initial amount: NaN
name: 6-Hydroxymelatonin
constant: false
initial concentration: 1.0
is: HMDB04081
is: http://identifiers.org/pubchem.compound/7954
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
has only substance units: false
is: C05643

http://identifiers.org/biomodels.db/MODEL1310110047#_ca36171d_aee1_4006_ac5c_a5b5c5b51236
boundary condition: true
has only substance units: false
is: G3V4L5
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC25A21
initial concentration: NaN
is encoded by: hsa:89874

metaR CHSTEROLtrc
fast: false
name: transport of cholesterol into the cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction

metaR r1772
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
reversible: false
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000000

metaM nad c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: C00003
initial amount: NaN
is: CHEBI:57540
constant: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305

metaM glc D l
type: Species
is: SBO:0000247
is: CHEBI:4167
initial amount: NaN
boundary condition: false
name: D-glucose
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM mi145p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: HMDB01498
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:203600
type: Species
initial concentration: 1.0
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
boundary condition: false

metaM dgdp n
initial concentration: 1.0
is: HMDB00960
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
name: dGDP(2-)
has only substance units: false
is: CHEBI:58595
is: SBO:0000247
boundary condition: false

metaM 3decdicoa x
name: 3,7-decadienoylcoa
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
type: Species

metaR r2443
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR GLCMter
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
fast: false
reversible: false
type: Reaction
name: glucose transport via membrane vesicle
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185

metaR SCP2x
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
name: peroxisomal thiolase 2
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.176

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
initial amount: NaN
boundary condition: false
is: CHEBI:26174
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: nLc8Cer
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110047#_1112a141_4a0e_49c7_9002_7537b5e1c0a0
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: _AL050025_1_c
initial concentration: NaN
is encoded by: hsa:AL050025
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_80cde2b3_c0c7_4ea0_b703_3fa8c83dee85
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: KHK
type: Species
is encoded by: hsa:3795
boundary condition: true
is: Q6IBK2

metaR r1779
reversible: false
modifier: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110047#

metaM lys L n
is: SBO:0000247
type: Species
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
name: L-lysinium(1+)
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:32551
initial concentration: 1.0

metaR HOCTDACBP
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM CE4792 m
has only substance units: false
boundary condition: false
is: CHEBI:57923
name: 3-oxo-cis-8-tetradecenoyl-CoA
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792

http://identifiers.org/biomodels.db/MODEL1310110047#_5b36ff30_32f0_4f58_a228_4d02bfa989bd
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: Q7Z364
boundary condition: true
name: PDE1B
initial concentration: NaN
is encoded by: hsa:5153
is: SBO:0000252

metaM thcholstoic x
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
is: SBO:0000247
is: CHEBI:18402
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species

W3 CDTF: Thu Aug 30 15:48:25 BST 2012

metaR DPMVDc
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is version of: http://identifiers.org/ec-code/4.1.1.33
reactant: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
name: diphosphomevalonate decarboxylase, cytosol
reversible: false
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000134
fast: false

metaM dgdp m
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
is: CHEBI:58595
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: dGDP(2-)
is: HMDB00960

http://identifiers.org/biomodels.db/MODEL1310110047#_d4d14ce6_f742_4e58_b022_0897ae030b62
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ASL
is: E9PE48
initial amount: NaN
is encoded by: hsa:435
is: SBO:0000252

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaM 4mop e
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial concentration: 1.0
is: HMDB00695
name: 4-methyl-2-oxopentanoate
boundary condition: false
is: CHEBI:17865
constant: false
type: Species
is: SBO:0000247

metaM bilirub c
initial amount: NaN
name: bilirubin(2-)
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00054
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
constant: false

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR GLCNACASE5ly
modifier: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
reversible: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_4390b6b4_c2b0_457c_a244_e587ab114f6a
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:26
type: Species
constant: false
is: P19801
boundary condition: true
is: SBO:0000252
name: ABP1

metaR F1PGT
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.7.30
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
name: fucose-1-phosphate guanylyltransferase
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_ba825a9e_6695_4d05_a069_ed8d0721be65
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54363
name: HAO1
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q9UJM8

W3 CDTF: Thu Aug 30 15:48:25 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110047#_9d39c196_d57b_41e9_85d1_0cf4fa9d3b0c
constant: false
is: SBO:0000252
is encoded by: hsa:2235
initial amount: NaN
boundary condition: true
is: Q7KZA3
has only substance units: false
name: FECH
initial concentration: NaN
type: Species

metaR ADNtm
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
name: adenosine facilated transport in mitochondria
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_f00e9276_2ca2_437d_b231_75930257e529
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5152
constant: false
is: SBO:0000252
name: PDE9A

metaR PRPNCOAHYDm
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
kinetic law: MODEL1310110047#
name: Propenoyl-CoA hydrolase (m)
is described by: ECO:0000134
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110047#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_ca40fe36_b903_4c1a_9378_13eb22a4ec64
initial amount: NaN
has only substance units: false
name: _AI972237_1_c
initial concentration: NaN
is encoded by: hsa:AI972237
boundary condition: true
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_320935f5_e095_4249_9fa2_fac06ab7d27f
is encoded by: hsa:5136
type: Species
is: P54750
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PDE1A
constant: false
initial amount: NaN

metaR SEBACACT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR MALSO3tm
modifier: MODEL1310110047#
type: Reaction
name: Malate:sulfite antiport, mitochondrial
is: SBO:0000185
reactant: MODEL1310110047#
reversible: true
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000269
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM xol25oh r
constant: false
is: CHEBI:42977
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 25-hydroxycholesterol
type: Species
has only substance units: false
is: HMDB06247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_7848828a_1f29_4c83_ab2e_a4ad44436fd4
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: P43353
initial amount: NaN
has only substance units: false
is encoded by: hsa:221
name: ALDH3B1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_87860ca3_81e9_4219_876f_62bbfead3897
is: Q96EK6
type: Species
initial amount: NaN
name: GNPNAT1
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:64841
initial concentration: NaN

metaM 4mop c
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
is: HMDB00695
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
is: CHEBI:17865

metaM bilirub e
is: CHEBI:57977
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
initial amount: NaN
boundary condition: false

metaR C6DCc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaR GAMt1r
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110047#
name: glucosamine transport (uniport)
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true
is: SBO:0000185
fast: false

metaM h2o2 c
is: CHEBI:16240
type: Species
initial amount: NaN
is: HMDB03125
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
name: Hydrogen peroxide
initial concentration: 1.0
has only substance units: false
is: C00027
boundary condition: false

metaR CYTDK1
is described by: ECO:0000254
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.1.48
type: Reaction
fast: false
name: ATPcytidine 5-phosphotransferase
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176

metaR FAOXC103C102m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR r0830
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110047#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110047#
product: MODEL1310110047#
fast: false

metaM trdrd m
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
name: Reduced thioredoxin
is: CHEBI:15967
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
is: HMDB00257
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
boundary condition: false
is: CHEBI:16094
has only substance units: false
initial amount: NaN

metaM nadh c
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
constant: false
is: C00004
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_7171a6ab_5d10_4f27_88c9_a6d604aaa6f1
is: SBO:0000252
is: O43674
boundary condition: true
constant: false
has only substance units: false
name: NDUFB5
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:4711

metaM acglcgalgluside hs g
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
is: CHEBI:17103
is: SBO:0000247
type: Species
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
initial concentration: 1.0
constant: false
boundary condition: false

metaM core6 l
boundary condition: false
has only substance units: false
is: HMDB00143
constant: false
initial amount: NaN
name: Core 6
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_6b9cbf98_5cb8_4640_aa59_7797229613a6
has only substance units: false
is: Q9Y5L3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:954
type: Species
name: ENTPD2
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_d52b5168_8769_416c_b527_9dd6617aca73
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA532636
is: SBO:0000252
type: Species
name: _AA532636_1_m

metaM dmhptcrn m
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06320
constant: false
name: 2,6 dimethylheptanoyl carnitine
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
is: SBO:0000247

metaM datp m
type: Species
initial amount: NaN
is: HMDB01532
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
name: dATP
constant: false
has only substance units: false
is: SBO:0000247
is: C00131
boundary condition: false
is: CHEBI:61404

metaR APOCF
kinetic law: MODEL1310110047#
type: Reaction
fast: false
name: Apocarboxylase formation
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
reversible: false
reactant: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_3c7a7960_ef6f_4b76_9f3e_da9704aa61b6
constant: false
has only substance units: false
is: B7Z1R0
type: Species
name: SLC4A10
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:57282
is: SBO:0000252

metaR EX 3octdece1crn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR HSPGtly
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: heparan sulfate transport, extracellular to lysosome
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110047#

metaR NAGLCAly
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
product: MODEL1310110047#
fast: false
type: Reaction
name: N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000

metaR TCHOLAtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false

metaR H7ET2er
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.1
reversible: false
fast: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_948b889a_8370_4ff9_89a9_91804d36510a
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:8398
constant: false
initial amount: NaN
has only substance units: false
name: PLA2G6
is: SBO:0000252
is: A8K460

http://identifiers.org/biomodels.db/MODEL1310110047#_d5a4e597_e322_4f87_91df_c5eaa2c8ba8f
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O43820
constant: false
boundary condition: true
is encoded by: hsa:8372
type: Species
name: HYAL3

http://identifiers.org/biomodels.db/MODEL1310110047#_a61d6953_ef9f_4393_b6a5_d7ea6e3379df
type: Species
name: ADHFE1
boundary condition: true
is: SBO:0000252
is: Q8IWW8
is encoded by: hsa:137872
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

metaM 34hpp e
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
type: Species
is: CHEBI:36242
constant: false
is: HMDB00707
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 3-(4-hydroxyphenyl)pyruvate
initial concentration: 1.0
boundary condition: false

metaR FAOXC180x
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) NJ
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM dcholcoa x
has only substance units: false
is: HMDB06292
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_0c9e1ff2_b826_4dd4_80a1_8fb41d55cae7
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: ND2
is encoded by: hsa:4536
is: Q7GXY9
initial amount: NaN

metaM phytcoa x
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
is: CHEBI:57391
is: HMDB01359
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: phytanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110047#_e26e53ba_48de_4092_ac1a_c1caca5efdd4
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5144
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q08499
name: PDE4D

metaR G14T6g
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
fast: false
reactant: MODEL1310110047#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_7e9fe27b_7ce9_4276_8767_4352268ad02a
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:126
is: P00326
type: Species
is: SBO:0000252
boundary condition: true
name: ADH1C

metaM cgly e
constant: false
name: L-cysteinylglycine
has only substance units: false
is: CHEBI:4047
type: Species
is: HMDB00078
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM h2o2 e
initial amount: NaN
is: CHEBI:16240
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
name: hydrogen peroxide
is: HMDB03125
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaR MI1PS
is: SBO:0000176
reversible: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.5.1.4
type: Reaction
name: myo-Inositol-1-phosphate synthase
product: MODEL1310110047#

metaR r0836
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR PNTEH
name: Hydrolase Class ( RXN R02973)
is described by: ECO:0000269
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
kinetic law: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.92
type: Reaction
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176

metaM retinol 9 cis c
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB06217
boundary condition: false
name: 9-cis-retinol
has only substance units: false
constant: false
is: CHEBI:17336
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

http://identifiers.org/biomodels.db/MODEL1310110047#_6b4d551b_6257_4609_8daf_1927690671f8
initial amount: NaN
boundary condition: true
name: SRD5A2
constant: false
initial concentration: NaN
is: SBO:0000252
is: P31213
has only substance units: false
is encoded by: hsa:6716
type: Species

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_cd207365_a493_4b8c_a4fd_40249238d9d9
has only substance units: false
boundary condition: true
name: DGUOK
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1716
is: Q16854
initial amount: NaN

metaM ala D c
name: D-alanine
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:15570
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1

metaM nad m
initial concentration: 1.0
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
boundary condition: false
is: HMDB00902
has only substance units: false
is: C00003
name: Nicotinamide adenine dinucleotide
constant: false
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110047#_41257275_4dc7_4ec4_809f_c6afcce99a00
initial concentration: NaN
is: SBO:0000252
name: TBXAS1
is: Q53F23
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6916
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_ae9d5feb_bb70_4643_86c9_9a594e4ee6ca
constant: false
is encoded by: hsa:AI640625
has only substance units: false
name: _AI640625_1_c
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaM dlnlcgcoa c
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:27979
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110047#_9357a674_8d72_40a8_a0ac_ec94e895173c
name: LHPP
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:64077
constant: false
is: Q9H008
is: SBO:0000252

metaR r0946
reversible: true
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR PMTCOAtx
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
type: Reaction
name: fatty acid intracellular transport

metaR RE1342C
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110047#
name: RE1342
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110047#
type: Reaction
fast: false

metaR CLOXAtex2
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
product: MODEL1310110047#
reversible: false
name: chloride transport via oxalate countertransport (2:1)
fast: false
is described by: ECO:0000304

metaR ADMDC
is version of: http://identifiers.org/ec-code/4.1.1.50
is: SBO:0000176
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: adenosylmethionine decarboxylase
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
reactant: MODEL1310110047#

metaR GALK
fast: false
product: MODEL1310110047#
name: galactokinase
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.157
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/2.7.1.6
reversible: false
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_b75222d8_17b7_4fc0_9eea_55960664e20f
constant: false
has only substance units: false
name: ME3
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: Q6TCH8
initial concentration: NaN
is encoded by: hsa:10873

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
name: blood group intracellular transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_716886df_53bd_4bfb_b9e4_d033e9635551
is: Q9BYZ2
initial concentration: NaN
name: LDHAL6B
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:92483
initial amount: NaN
type: Species

metaM 6pgl r
is: HMDB01127
is: CHEBI:57955
initial concentration: 1.0
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
constant: false
has only substance units: false

metaM cgly c
name: L-cysteinylglycine
has only substance units: false
is: CHEBI:4047
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: HMDB00078
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM datp n
type: Species
boundary condition: false
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01532
initial concentration: 1.0
name: dATP
is: C00131
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_b772e198_7a90_45cd_b45c_028484b09271
initial amount: NaN
name: FUT9
is encoded by: hsa:10690
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q9Y231

metaM pram c
constant: false
is: C03090
name: 5-Phospho-beta-D-ribosylamine
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
type: Species
is: SBO:0000247
is: CHEBI:58681
boundary condition: false
is: HMDB01128
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM b2coa m
has only substance units: false
is: HMDB02009
name: crotonoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57332
is: SBO:0000247

metaR r0834
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110047#

metaR PEt
type: Reaction
reactant: MODEL1310110047#
name: phosphatidylethanolamine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_5bdc7fa4_b720_407a_9a9f_7dec07af5ff5
is: SBO:0000252
boundary condition: true
type: Species
is: P36957
name: DLST
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:1743

metaM 34hpp c
initial concentration: 1.0
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
is: CHEBI:36242
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

http://identifiers.org/biomodels.db/MODEL1310110047#_95c42859_1ceb_4633_9333_50d255e2239e
is encoded by: hsa:9091
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: PIGQ
is: Q9BRB3
initial concentration: NaN

metaR UDPGP
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (5167.1) or (5169.1) or (5168.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110047#
reversible: false
fast: false
kinetic law: MODEL1310110047#
name: UDPglucose pyrophosphohydrolase
is version of: http://identifiers.org/ec-code/3.1.4.39
modifier: MODEL1310110047#

metaM c6dc c
notes: FORMULA: C13H22NO6 CHARGE: -1
initial concentration: 1.0
is: HMDB00705
has only substance units: false
name: adipoyl carnitine
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaR LNSTLSr
type: Reaction
name: lanosterol synthase
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
is described by: ECO:0000134
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.4.99.7
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaR B3GNT310g
reversible: false
kinetic law: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
type: Reaction
modifier: MODEL1310110047#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaM ala D e
boundary condition: false
has only substance units: false
name: D-alanine
initial amount: NaN
is: HMDB01310
initial concentration: 1.0
is: CHEBI:15570
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
constant: false
is: SBO:0000247

metaM hs deg17 l
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: HMDB02704
name: heparan sulfate, degradation product 17
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:21338
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_61c782ba_022c_4a43_beb9_50b59e5388b1
name: SDHC
is: Q99643
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6391
has only substance units: false

metaM sgalside hs l
type: Species
initial concentration: 1.0
is: HMDB00904
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN
is: CHEBI:16349
is: SBO:0000247
constant: false
boundary condition: false
name: sulfatide galactocerebroside

metaR H2O2tn
reversible: true
fast: false
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: hydrogen peroxide nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR B3GNT311g
is described by: ECO:0000254
kinetic law: MODEL1310110047#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_dcb8c22f_ec52_4956_af14_3a9132822d15
name: NME2
initial concentration: NaN
initial amount: NaN
is: P22392
has only substance units: false
is encoded by: hsa:4831
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaR 3AIBTm
name: L-3-aminoisobutyrate transaminase, mitochondrial
is: SBO:0000176
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000304
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_cd2efa19_dc71_4789_afe5_dfb38b089365
initial concentration: NaN
name: ACAD8
is encoded by: hsa:27034
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: Q6ZWP6
type: Species

metaR SBT Dtde
fast: false
is: SBO:0000185
reversible: true
name: D-sorbitol transport, extracellular
kinetic law: MODEL1310110047#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaR TMDS
kinetic law: MODEL1310110047#
is described by: ECO:0000269
name: thymidylate synthase
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.1.1.45
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_07134975_fafb_4a5a_8f1e_1bcca9f4c76c
has only substance units: false
is: P00918
is encoded by: hsa:760
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: CA2
initial concentration: NaN
is: SBO:0000252

metaM 2maacoa m
has only substance units: false
is: CHEBI:57335
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
initial amount: NaN
is: HMDB01157
is: SBO:0000247
constant: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
boundary condition: false
type: Species

metaM sphings c
boundary condition: false
is: HMDB00252
name: sphingosine(1+)
initial concentration: 1.0
constant: false
is: CHEBI:57756
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319

metaM 4abut e
boundary condition: false
name: 4-Aminobutanoate
initial amount: NaN
initial concentration: 1.0
is: C00334
type: Species
constant: false
is: SBO:0000247
is: CHEBI:3628
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f8e48500_c0c3_44c8_9083_83e16e4f1cd1
boundary condition: true
initial amount: NaN
is: Q9BV10
is encoded by: hsa:79087
type: Species
name: ALG12
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaM lnlccrn c
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247
is: HMDB06469
type: Species
initial amount: NaN
name: Linoleyl carnitine
initial concentration: 1.0
constant: false
has only substance units: false

metaM HC01603 c
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57454
is: C00234
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM CE4793 x
constant: false
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793
is: CHEBI:57923
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 3-oxo-dihomo-gama-linolenoyl-CoA

metaM HC01434 c
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
boundary condition: false
is: CHEBI:58931
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: oxalatosuccinate(3-)
has only substance units: false

metaR C141OHe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR 2HBt2
reversible: true
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000185
name: 2-hydroxybutyrate cotransport with proton
is described by: ECO:0000269
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR ITCOALm
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000212
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
reactant: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#

metaM cs e deg5 l
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
is: CHEBI:57737
notes: FORMULA: C31H47NO35S3 CHARGE: -4
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00868

metaM phytcoa c
is: CHEBI:57391
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
is: SBO:0000247
name: phytanoyl-CoA(4-)
type: Species
is: HMDB01359
initial amount: NaN

metaR GALGLUSIDEtg
reversible: true
type: Reaction
product: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110047#
fast: false
name: galgluside hs intracellular transport
reactant: MODEL1310110047#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_003b93c4_196b_417b_8409_9b8d8d0e421d
constant: false
type: Species
name: SLC25A2
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:83884
is: Q9BXI2

metaR UAGDP
is described by: ECO:0000269
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.23
is: SBO:0000176
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
reactant: MODEL1310110047#

metaR ACGPID
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is version of: http://identifiers.org/ec-code/3.5.1.89
product: MODEL1310110047#
fast: false
type: Reaction
reactant: MODEL1310110047#

metaR PItg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: phosphate transport, Golgi apparatus
type: Reaction
reversible: false
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#

metaM HC00361 c
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial concentration: 1.0
constant: false
is: CHEBI:58335
is: SBO:0000247
name: sedoheptulose 1,7-bisphosphate(4-)
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

metaR FAOXC103C102x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_bd8024a2_edfb_432e_9870_f7ba7c7e3a75
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:8883
initial amount: NaN
name: NAE1
initial concentration: NaN
is: A8MU28
boundary condition: true
constant: false

metaR HKYNH
reactant: MODEL1310110047#
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110047#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8942.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 4 AUTHORS: PMID:9180257 NOTES:NCD
name: 3-Hydroxy-L-kynurenine hydrolase
is version of: http://identifiers.org/ec-code/3.7.1.3
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

metaM dec47dicoa x
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
initial amount: NaN
name: 4,7-decadienoylcoa
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_c0c70b0c_61d4_4a0a_8b66_8b5dbd0917b1
constant: false
type: Species
is encoded by: hsa:3141
is: P50747
initial amount: NaN
boundary condition: true
name: HLCS
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_6e467bba_dde3_4522_aa37_ac8a3c490c5c
name: EARS2
has only substance units: false
is: Q5JPH6
type: Species
is encoded by: hsa:124454
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM hs deg20 l
initial amount: NaN
type: Species
is: CHEBI:16126
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: heparan sulfate, degradation product 20
notes: FORMULA: C45H68N2O43S2 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110047#_b3b39d78_cac0_460a_b4bd_ee89017b7f0f
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:27165
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: GLS2

metaR THRASNNaEx
modifier: MODEL1310110047#
is described by: ECO:0000269
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#

metaR H2O2tp
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110047#
name: hydrogen peroxide peroxisomal transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
kinetic law: MODEL1310110047#

metaM 4ppcys m
has only substance units: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
constant: false
type: Species
is: CHEBI:59458
is: HMDB01117
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM 4abut c
is: HMDB00112
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
type: Species
boundary condition: false
name: 4-Aminobutanoate
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:3628
is: C00334

http://identifiers.org/biomodels.db/MODEL1310110047#_27959aef_fe05_4373_868c_f3fb058f6895
is: SBO:0000252
constant: false
name: SLC5A9
has only substance units: false
is encoded by: hsa:200010
initial concentration: NaN
is: E9PAK4
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_8d9b3c4e_b9b2_44df_8a2c_134a8b1e55a9
initial amount: NaN
boundary condition: true
is: Q9NZK7
type: Species
name: PLA2G2E
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:30814

http://identifiers.org/biomodels.db/MODEL1310110047#_eac5e22d_fe9b_43cd_b94b_4641166fe7ab
boundary condition: true
is: P05062
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: ALDOB
is: SBO:0000252
is encoded by: hsa:229

http://identifiers.org/biomodels.db/MODEL1310110047#_86854fa9_9c29_48f7_a4cb_d0fc4cb84724
is encoded by: hsa:280
is: P19961
type: Species
name: AMY2B
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaM nrvnccoa x
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: nervonyl coenzyme A
is: C16532

http://identifiers.org/biomodels.db/MODEL1310110047#_7f81c373_f3ff_4fb9_98cb_cec7f7d88109
is encoded by: hsa:4967
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: OGDH
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q02218

http://identifiers.org/biomodels.db/MODEL1310110047#_ac5b6338_87a1_4564_bff5_5e198bce6113
name: GALNS
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P34059
is encoded by: hsa:2588
has only substance units: false

metaM apoC Lys c
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: HMDB00182
has only substance units: false
type: Species
is: CHEBI:32551
initial amount: NaN
constant: false
name: Apocarboxylase (Lys residue)

metaM hmbil c
constant: false
is: HMDB01137
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57845
name: Hydroxymethylbilane
is: C01024
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024

metaM e4p c
has only substance units: false
is: HMDB01321
is: SBO:0000247
name: D-Erythrose 4-phosphate
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
constant: false
initial concentration: 1.0
is: CHEBI:16897
initial amount: NaN
boundary condition: false
is: C00279
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_1dbe4c5e_3bb0_414e_84bb_e06f00204f10
type: Species
has only substance units: false
name: PCBD1
initial concentration: NaN
is encoded by: hsa:5092
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaM mag hs e
is: SBO:0000247
name: monoacylglycerol 2
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:60479
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_1e8ece06_e8e9_4f02_9170_4b25668b85a0
type: Species
is: O14832
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5264
name: PHYH

http://identifiers.org/biomodels.db/MODEL1310110047#_967f9635_6711_44d4_8946_bb18ffa3fd13
is: Q6ZMU0
boundary condition: true
is encoded by: hsa:210
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: ALAD

metaR FAOXC101C102m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR r0698
is: SBO:0000176
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.2.27

metaM pmtcoa x
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
type: Species
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: C00154
has only substance units: false
constant: false
is: CHEBI:57379

metaR ADSL1
modifier: MODEL1310110047#
type: Reaction
name: adenylosuccinate lyase
reactant: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/4.3.2.2
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110047#

metaR GALGLUSIDEtl
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000000
fast: false
type: Reaction
name: galgluside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110047#

metaM 3octdeccrn e
boundary condition: false
name: 3-hydroxyoctadecanoyl carnitine
is: HMDB13336
is: SBO:0000247
notes: FORMULA: C25H49NO5 CHARGE: 0
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR r0840
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000185
name: Free diffusion
modifier: MODEL1310110047#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.70
kinetic law: MODEL1310110047#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_0772cd45_a062_4757_bcf8_1b09b2b68ea6
initial amount: NaN
is encoded by: hsa:1109
name: AKR1C4
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P17516
is: SBO:0000252
type: Species
constant: false

metaM sprm e
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
initial amount: NaN
name: spermine(4+)
is: HMDB01256
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:45725

metaM CE2434 m
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
type: Species
is: CHEBI:57795

metaM so4 l
initial amount: NaN
is: HMDB01448
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
is: SBO:0000247
name: sulfate
is: CHEBI:16189
type: Species

metaR RE1903R
type: Reaction
name: RE1903
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

metaR MACACI
is version of: http://identifiers.org/ec-code/2.5.1.18
is described by: ECO:0000269
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is: SBO:0000176
name: maleylacetoacetate isomerase
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
reversible: false
reactant: MODEL1310110047#

metaR CYTK14
product: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
name: cytidylate kinase (dCMP,UTP)

metaR GTHRDt
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reversible: true
type: Reaction
name: Glutathione transport into mitochondria

metaR biomass reaction
reversible: false
product: MODEL1310110047#
fast: false
is described by: ECO:0000134
type: Reaction
name: Generic human biomass reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110047#

metaR CDSm
is version of: http://identifiers.org/ec-code/2.7.7.41
name: phosphatidate cytidylyltransferase
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
is: SBO:0000176

metaM no e
initial concentration: 1.0
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
is: CHEBI:16480
boundary condition: false
is: HMDB03378
has only substance units: false
constant: false
is: C00533
name: Nitric oxide
is: SBO:0000247
initial amount: NaN

metaR ADSL2
is version of: http://identifiers.org/ec-code/4.3.2.2
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
modifier: MODEL1310110047#
fast: false
name: adenylosuccinate lyase
is described by: ECO:0000269
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_47baad0f_74ce_45c2_9cb0_9e34e30bed19
boundary condition: true
is encoded by: hsa:2821
initial amount: NaN
name: GPI
initial concentration: NaN
type: Species
is: P06744
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_6093f88f_a7af_4e4c_8ddf_c1c1d1e59c16
boundary condition: true
initial concentration: NaN
is: O60547
has only substance units: false
is encoded by: hsa:2762
initial amount: NaN
constant: false
name: GMDS
type: Species
is: SBO:0000252

metaM nh4 x
boundary condition: false
constant: false
type: Species
name: Ammonium
is: C01342
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
is: HMDB00051
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:28938

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110047#_b202fe32_9dcd_4ce3_9e0b_103a0ac503a8
is: SBO:0000252
name: SMPD3
type: Species
has only substance units: false
is encoded by: hsa:55512
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: Q9NY59

metaR S6T14g
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000000
fast: false
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_0fa3d10b_c4f7_41a8_8105_69327a463141
is encoded by: hsa:3295
initial concentration: NaN
name: HSD17B4
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: E9PB82
is: SBO:0000252
boundary condition: true

metaR THRGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110047#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
product: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000185

metaR r2447
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110047#
name: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.3
product: MODEL1310110047#

metaR CYTK13
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110047#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (dCMP,dATP)

metaR UPPN
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.6
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000269
reversible: false
name: b-ureidopropionase

metaM 3octpencoa m
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3,6,9,12,15-octadecapentenoylcoa
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
boundary condition: false
constant: false

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_93654bfa_d97d_4a8b_9625_865bb89739f3
type: Species
is encoded by: hsa:U37519
constant: false
name: _U37519_1_e
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_43807f1c_3f4d_49bf_8892_29eca12ec1f6
initial concentration: NaN
constant: false
is: P54802
is encoded by: hsa:4669
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: NAGLU

metaR FAOXC16C16OHm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaM lys L m
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
is: HMDB00182
name: L-lysinium(1+)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32551
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM 3octdeccrn c
name: 3-hydroxyoctadecanoyl carnitine
notes: FORMULA: C25H49NO5 CHARGE: 0
is: HMDB13336
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_db912f9f_ff0e_4bc0_ba07_e84df4c7dfbd
type: Species
name: TM7SF2
is encoded by: hsa:7108
is: SBO:0000252
constant: false
initial concentration: NaN
is: O76062
initial amount: NaN
boundary condition: true
has only substance units: false

metaR FCLTm
product: MODEL1310110047#
fast: false
type: Reaction
modifier: MODEL1310110047#
is described by: ECO:0000304
reversible: false
is: SBO:0000176
name: Ferrochelatase, mitochondrial
is version of: http://identifiers.org/ec-code/4.99.1.1
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096

metaR CRNCAR3tp
is: SBO:0000185
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
name: carnitine-propcarnitine carrier, peroxisomal
is described by: ECO:0000000

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110047#_49cba0d6_edc9_4b39_9008_cbb32f77fb37
is: Q9NXB9
type: Species
initial concentration: NaN
is encoded by: hsa:54898
boundary condition: true
name: ELOVL2
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaM tym c
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00306
is: CHEBI:327995
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
type: Species
initial concentration: 1.0
name: tyraminium
is: SBO:0000247
has only substance units: false

metaR CYTK12
reactant: MODEL1310110047#
reversible: true
product: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110047#
name: cytidylate kinase (dCMP,dCTP)
modifier: MODEL1310110047#
is described by: ECO:0000269
type: Reaction
fast: false

metaM 3hddcoa m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: HMDB11123
initial amount: NaN
type: Species
has only substance units: false
is: C05279
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_bba3d07d_af45_4b29_b2fa_7a263661eb31
boundary condition: true
name: _AI222095_1_m
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI222095
initial concentration: NaN
constant: false
type: Species

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR S6TASE16ly
is described by: ECO:0000000
product: MODEL1310110047#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110047#
fast: false
type: Reaction
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110047#
is: SBO:0000176

metaR ASNTHRNaEx
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110047#

metaM nad r
is: SBO:0000247
is: CHEBI:57540
name: NAD(1-)
boundary condition: false
is: HMDB00902
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial concentration: 1.0

metaR BTNPL
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110047#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110047#
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase)
modifier: MODEL1310110047#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
type: Species
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
is: CHEBI:61648
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM so4 m
is: CHEBI:16189
has only substance units: false
is: SBO:0000247
name: sulfate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
initial amount: NaN
is: HMDB01448
constant: false

metaM acglcgalgbside hs g
initial concentration: 1.0
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:26174
name: GlcNAc-Gal globoside
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_1e07f8cd_5b47_42f5_9ef0_fe878108c4ae
is: SBO:0000252
constant: false
initial amount: NaN
is: P00441
name: SOD1
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6647

metaR CYTK11
reversible: true
reactant: MODEL1310110047#
name: cytidylate kinase (dCMP,dGTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR 3HAO
is: SBO:0000176
modifier: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (23498.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.6 Confidence Level: 4 AUTHORS: PMID:7514594 NOTES:NCD
name: 3-hydroxyanthranilate 3,4-dioxygenase
is version of: http://identifiers.org/ec-code/1.13.11.6
product: MODEL1310110047#

metaM dolglcp U r
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species
is: CHEBI:15812
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_e6958d35_4c83_4de8_b621_87b0d367d182
has only substance units: false
constant: false
is: Q9UGQ3
boundary condition: true
is: SBO:0000252
type: Species
name: SLC2A6
is encoded by: hsa:11182
initial concentration: NaN
initial amount: NaN

metaM dc2coa x
has only substance units: false
initial amount: NaN
boundary condition: false
name: trans-Dec-2-enoyl-CoA
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01168
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaR CYTK10
is: SBO:0000176
modifier: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000269
reactant: MODEL1310110047#
fast: false
name: cytidylate kinase (CMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR FACOAL204
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
name: fatty-acid--CoA ligase
fast: false

metaM CE0785 m
has only substance units: false
name: cis,cis-myristo-5,8-dienoyl-CoA
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: CHEBI:57795
boundary condition: false

metaR FAOXC101C102x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR FUMAC
type: Reaction
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.7.1.2
is: SBO:0000176
product: MODEL1310110047#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
name: fumarylacetoacetase
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaM CE2416 x
constant: false
is: CHEBI:57923
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: (2R,6S,10S)-pristanate
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
initial concentration: 1.0
initial amount: NaN

metaR THYOXt2
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
fast: false
product: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110047#
name: T4 transport via facilitated diffusion

metaR C181CRNt
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000000
name: C181 transport into the mitochondria
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
type: Reaction

metaR MI14PP
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.57
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reversible: false
fast: false
reactant: MODEL1310110047#
type: Reaction
name: inositol-1,4-bisphosphate 1-phosphatase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_6440f61c_626f_45d3_9f2b_a3675973dd7e
initial concentration: NaN
is: P30048
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: PRDX3
has only substance units: false
boundary condition: true
is encoded by: hsa:10935

metaR 3DPHBH1
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110047#
reversible: false
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
kinetic law: MODEL1310110047#

metaR r1051
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: true
name: Vesicular transport
is: SBO:0000185

metaM adrnl c
name: Adrenaline
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
is: SBO:0000247
is: HMDB00068
initial amount: NaN
initial concentration: 1.0
is: CHEBI:33568

metaR FAOXC10C8x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ce25863d_244a_4a47_92d9_dff01a40ddfd
name: B3GNT3
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: Q9Y2A9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10331
boundary condition: true

metaR HEXDCRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaR FACOAL205
modifier: MODEL1310110047#
name: fatty-acid--CoA ligase
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110047#_8bc0ebc1_6ae5_47ce_938d_1280615e06c4
type: Species
name: ST3GAL3
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6487
boundary condition: true
initial concentration: NaN
constant: false
is: Q5T4W8

metaM sgalside hs c
is: SBO:0000247
is: HMDB03406
is: CHEBI:16523
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: sulfatide galactocerebroside
constant: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
has only substance units: false

metaM HC01397 m
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: (S)-3-Hydroxyhexadecanoyl-CoA
constant: false
is: CHEBI:27402

http://identifiers.org/biomodels.db/MODEL1310110047#_1e7a696f_9530_4bc3_a745_c8af8b24693b
name: ALDH1B1
type: Species
initial concentration: NaN
is: P30837
is encoded by: hsa:219
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR PI45P3K
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
reversible: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM phyt x
name: phytanate
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00801
is: CHEBI:37257
initial amount: NaN
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607

http://identifiers.org/biomodels.db/MODEL1310110047#_04f6e6f1_9cd1_4bbf_89f7_3c4b360c486e
boundary condition: true
initial concentration: NaN
constant: false
is: Q96KH8
initial amount: NaN
is encoded by: hsa:6530
has only substance units: false
type: Species
name: SLC6A2
is: SBO:0000252

metaM 4ppcys c
is: SBO:0000247
type: Species
is: C04352
is: CHEBI:59458
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

metaM nad x
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: C00003
type: Species
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
is: HMDB00902
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_16583676_3ac6_4bf3_8f2e_6c2db95bca86
is: P51857
has only substance units: false
name: AKR1D1
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6718

metaR ADEt
is: SBO:0000185
reversible: true
modifier: MODEL1310110047#
name: adenine reversible transport, cytosol
is described by: ECO:0000269
product: MODEL1310110047#
type: Reaction
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD

metaM 44mctr r
boundary condition: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
type: Species
is: HMDB01023
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: CHEBI:17813
initial concentration: 1.0

metaR PSDm hs
is version of: http://identifiers.org/ec-code/4.1.1.65
reactant: MODEL1310110047#
is described by: ECO:0000269
name: Phosphatidylserine decarboxylase
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ

metaR FACOAL206
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase

metaR GLYAMDTRc
type: Reaction
reactant: MODEL1310110047#
modifier: MODEL1310110047#
name: glycine amidinotransferase (c)
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.1.4.1
fast: false
product: MODEL1310110047#
is: SBO:0000176

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_9868e541_7356_432f_bc10_46d0767f6494
constant: false
is: SBO:0000252
is: P30038
is encoded by: hsa:8659
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ALDH4A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_e284e2ea_067f_40de_acb1_cc047c9ad736
is encoded by: hsa:79053
has only substance units: false
name: ALG8
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: A6NDW6
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_69e5c646_d042_41f7_b6dc_68f672b181c7
initial concentration: NaN
type: Species
is: Q9NS00
boundary condition: true
has only substance units: false
name: C1GALT1
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:56913

metaR r1619
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

metaR S4TASE2ly
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
reactant: MODEL1310110047#

metaM apoC Lys m
is: HMDB00182
boundary condition: false
initial amount: NaN
name: Apocarboxylase (Lys residue)
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13N2OX CHARGE: 0
initial concentration: 1.0
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110047#_4c5e0588_6e07_448d_9b64_5a6a0ac60ca4
is encoded by: hsa:4718
name: NDUFC2
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q549M5

metaM HC01672 c
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:37666
boundary condition: false
name: Acetyl adenylate
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993

http://identifiers.org/biomodels.db/MODEL1310110047#_d2581e39_0c59_455d_a1e3_9870dac1767d
boundary condition: true
is encoded by: hsa:AA081045
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AA081045_1_c
type: Species

metaR VLCSp
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110047#
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
type: Reaction
kinetic law: MODEL1310110047#
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110047#
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_da49b563_02bc_481d_b96c_47a04c402348
initial amount: NaN
constant: false
boundary condition: true
name: PIK3C2G
type: Species
is: O75747
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5288
is: SBO:0000252

metaR r1050
type: Reaction
is described by: ECO:0000000
name: Vesicular transport
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM btamp m
is: CHEBI:3110
name: Biotinyl-5'-AMP
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM naglc2p U c
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
is: SBO:0000247
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:18278
has only substance units: false
initial amount: NaN

metaM datp c
boundary condition: false
is: CHEBI:61404
is: C00131
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
is: HMDB01532
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM no c
is: HMDB03378
type: Species
is: SBO:0000247
is: CHEBI:16480
name: Nitric oxide
constant: false
has only substance units: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
initial amount: NaN
is: C00533
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_a7adc70e_2441_4250_9de2_d72df111b113
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: CHAT
type: Species
is encoded by: hsa:1103
is: Q6LEN5

http://identifiers.org/biomodels.db/MODEL1310110047#_e09c9fb2_c39d_4f10_a010_ae9a6d0fec34
is encoded by: hsa:6567
is: SBO:0000252
name: SLC16A2
initial concentration: NaN
has only substance units: false
type: Species
is: P36021
constant: false
boundary condition: true
initial amount: NaN

metaM g3pc c
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
type: Species
initial amount: NaN
name: sn-Glycero-3-phosphocholine
boundary condition: false
is: HMDB00086
is: CHEBI:16870

http://identifiers.org/biomodels.db/MODEL1310110047#_bb7a62fd_3445_4ed2_999b_9389bf7e2711
initial concentration: NaN
is: SBO:0000252
name: PDE3B
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: A7E2E5
is encoded by: hsa:5140
boundary condition: true

metaR RE1897C
name: RE1897
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
product: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
fast: false
reversible: true

metaR RE0937E
is version of: http://identifiers.org/ec-code/3.4.17.23
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
modifier: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
name: RE0937
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f6d0b091_8e8f_4433_bf36_cb424d532647
is: SBO:0000252
is encoded by: hsa:7054
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P78428
name: TH
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_a1424451_c616_47fa_a9cb_5050aad5b820
name: ACSL1
type: Species
is encoded by: hsa:2180
initial amount: NaN
has only substance units: false
is: P33121
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM nh4 n
is: SBO:0000247
type: Species
constant: false
is: HMDB00051
initial concentration: 1.0
name: ammonium
has only substance units: false
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
initial amount: NaN

metaM lys L c
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
is: SBO:0000247
boundary condition: false
is: HMDB00182
constant: false
name: L-lysinium(1+)
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR GALASE4ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
name: beta-galactosidase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_84cd3193_3ee2_4682_afc6_1e67deca7edc
boundary condition: true
is encoded by: hsa:H17063
name: _H17063_1_m
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR ME1m
is: SBO:0000176
kinetic law: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.38
type: Reaction
reversible: false
name: malic enzyme (NAD), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110047#_ee9ffecf_40de_45bc_894a_c94a390200b7
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: Q9H0P0
is encoded by: hsa:51251
has only substance units: false
initial amount: NaN
name: NT5C3
type: Species

metaR FACOAL200
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
fast: false
reactant: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110047#_7890ba8e_f7a8_435f_a4d0_1275cdd16a90
initial concentration: NaN
is: P55084
type: Species
boundary condition: true
has only substance units: false
name: HADHB
is: SBO:0000252
is encoded by: hsa:3032
constant: false
initial amount: NaN

metaR SUCCACT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaM hexccoa x
boundary condition: false
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
initial concentration: 1.0
has only substance units: false
is: HMDB06459
initial amount: NaN
name: Hexacosanoyl-CoA (n-C26:0CoA)
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_fbe668ff_18ba_43ed_901d_3087041d58d2
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AI926493
initial amount: NaN
is: SBO:0000252
name: _AI926493_1_c
constant: false
initial concentration: NaN

metaM glc D e
constant: false
is: HMDB00122
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:4167
has only substance units: false
name: D-glucose
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247

metaM sbt D e
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
boundary condition: false
constant: false
is: SBO:0000247
name: D-glucitol
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00247

metaM omhpal c
notes: FORMULA: C16H30O3 CHARGE: -1
boundary condition: false
name: w-hydroxypalmiticacid
is: HMDB06294
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaR r1617
product: MODEL1310110047#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_da1052d9_6597_4abc_b4dc_5e5221eed084
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:6817
name: SULT1A1
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_a774bbac_aafa_47da_9316_1c71da2f44a4
is encoded by: hsa:641371
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: ACOT1
initial amount: NaN
is: E9KL42
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3f70c5fb_e7bc_45ee_b0eb_52e4aadac772
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ABAT
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:18

metaM sgalside hs g
type: Species
name: sulfatide galactocerebroside
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
is: CHEBI:58343
is: SBO:0000247
is: HMDB00061
initial concentration: 1.0
has only substance units: false
constant: false

metaM acnamp c
is: HMDB06268
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
constant: false
type: Species
is: CHEBI:27438
initial concentration: 1.0
boundary condition: false
name: N-Acetylneuraminate 9-phosphate
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR RPE
reversible: true
type: Reaction
modifier: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.3.1
name: ribulose 5-phosphate 3-epimerase
product: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_cf3475e3_f549_4633_b46e_aecbaed68895
constant: false
type: Species
is: B4DZR2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8854
has only substance units: false
name: ALDH1A2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_757706bc_9edf_4b90_83bd_eb1842fd8e5b
is encoded by: hsa:54344
has part: Q9P2X0
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN
has only substance units: false
name: DPM3:DPM1:DPM2
is: SBO:0000297
type: Species
boundary condition: true
constant: false

metaM dlnlcgcoa r
is: C03595
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:27979
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM tdec4ecoa m
boundary condition: false
type: Species
initial amount: NaN
is: C08277
is: HMDB00792
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
initial concentration: 1.0
name: trans4decenoylcoa
has only substance units: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_9be38ccd_3559_44fd_a4ab_b7ec4f09c739
initial amount: NaN
is encoded by: hsa:218
is: SBO:0000252
name: ALDH3A1
initial concentration: NaN
boundary condition: true
is: P30838
has only substance units: false
constant: false
type: Species

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR FUM
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
name: fumarase
reversible: true
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction

metaM pail345p hs c
type: Species
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
is: CHEBI:57836
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR FAOXC260240x
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
product: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110047#_5a8e525b_cf4b_4a84_a840_98ec9c10ebfa
name: ECI1
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:1632
is: SBO:0000252
is: P42126
constant: false
has only substance units: false

metaR 3SALAASPm
product: MODEL1310110047#
fast: false
name: cysteinesulfinate-aspartate mitochondrial shuttle
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true

metaR r1618
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_96368a48_ccd6_47c6_b7be_e39beb673a3c
is: P80365
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3291
name: HSD11B2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_095f772b_4676_4bb1_a4f5_0afd208d70c5
initial amount: NaN
has part: Q9BQL0
is: SBO:0000297
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:594
name: DBT:DLD:BCKDHA:BCKDHB

http://identifiers.org/biomodels.db/MODEL1310110047#_cb63073b_c9c3_425e_afb5_d9ba29bea8f1
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:22978
initial amount: NaN
boundary condition: true
has only substance units: false
is: P49902
name: NT5C2
initial concentration: NaN

metaM lys L e
is: CHEBI:32551
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00182
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_615b2666_4539_46e1_927c_35149724df31
has part: E9PB82
initial amount: NaN
boundary condition: true
is encoded by: hsa:3295
type: Species
has only substance units: false
is: SBO:0000297
name: ACAA1:HSD17B4:ACOX1
initial concentration: NaN
constant: false

metaM lgt S c
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01066
has only substance units: false
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
name: (R)-S-lactoylglutathionate(1-)
boundary condition: false
is: CHEBI:57474

http://identifiers.org/biomodels.db/MODEL1310110047#_f5b42379_d9e6_4709_9a35_fab8bb92bd30
has only substance units: false
type: Species
is: O43837
name: IDH3B
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:3420
is: SBO:0000252

metaM h2o2 x
name: Hydrogen peroxide
has only substance units: false
constant: false
boundary condition: false
is: HMDB03125
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16240
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_f6c71a84_5125_4c7c_9e2e_5f52306a4de4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: FTCD
is: O95954
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:10841

metaR EX c3dc
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_1de0f503_9915_4fa1_be56_ce9b91dcab38
is: Q96P26
type: Species
constant: false
is encoded by: hsa:93034
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NT5C1B
is: SBO:0000252
has only substance units: false

metaM octdececrn m
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
type: Species
constant: false
initial concentration: 1.0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)

metaM glc D c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: D-glucose
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
constant: false
is: HMDB00122
has only substance units: false
type: Species

metaM arachd x
boundary condition: false
name: arachidonate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
constant: false
type: Species
is: HMDB01043
initial amount: NaN
has only substance units: false

metaR C3STDH1Pr
type: Reaction
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
kinetic law: MODEL1310110047#

metaR r1615
type: Reaction
modifier: MODEL1310110047#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RPI
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
name: ribose-5-phosphate isomerase
reactant: MODEL1310110047#

metaM sbt D c
is: HMDB00247
constant: false
is: SBO:0000247
name: D-glucitol
is: CHEBI:17924
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial amount: NaN
type: Species
boundary condition: false

metaM subeac x
constant: false
boundary condition: false
name: suberic acid
type: Species
initial concentration: 1.0
is: HMDB00893
initial amount: NaN
notes: FORMULA: C8H12O4 CHARGE: -2
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3fcd4dbe_f82c_4149_868a_dcb295c88246
name: GGT1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P19440
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2678
type: Species

metaM HC02023 r
initial concentration: 1.0
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: Cholesterol-ester-ol
type: Species
has only substance units: false
is: CHEBI:46898

http://identifiers.org/biomodels.db/MODEL1310110047#_101d31c6_a64b_4f73_b7f7_b51160709068
initial amount: NaN
has only substance units: false
is: O60733
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:8398
name: PLA2G6
is: SBO:0000252

metaM nh4 m
is: HMDB00051
name: Ammonium
is: C01342
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_498b0ae3_3520_499d_8733_f9f784475ac5
name: _AF116616_1_m
is encoded by: hsa:AF116616
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR NRVNCt
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185

metaM formcoa x
has only substance units: false
name: formyl-CoA(4-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
is: HMDB03419
constant: false
is: CHEBI:57376

metaR FACOAL203
reversible: true
type: Reaction
is described by: ECO:0000000
name: fatty-acid--CoA ligase
is: SBO:0000176
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110047#_37417855_02b1_4f3d_9c04_9d081199fd65
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI373818_1_m
initial concentration: NaN
is encoded by: hsa:AI373818
is: SBO:0000252
type: Species
constant: false

metaR NACHEX9ly
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction

metaR RE1233C
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
type: Reaction
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: RE1233
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.6.1.64

http://identifiers.org/biomodels.db/MODEL1310110047#_e211535f_7dfc_41a9_a374_9e23f3bd465e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2592
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: B2RAT6
boundary condition: true
name: GALT

metaR C141OHc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_c0c7d96a_8eaa_41ab_8cc4_cd6f38e596d2
initial concentration: NaN
type: Species
name: _AI761708_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI761708
constant: false

metaR r1616
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110047#

metaM tag1p D c
is: HMDB06328
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3,5-8,10-11H,1-2H2,(H2,12,13,14)/t3-,5+,6-/m1/s1
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: D-Tagatose 1-phosphate

metaM didp n
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
is: HMDB03536
is: CHEBI:28823
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: dIDP
type: Species
initial amount: NaN

metaM hpdcacoa c
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB06497
name: heptadecanoyl coa
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110047#_83992c86_65bb_470e_ad40_060536bc84c2
is encoded by: hsa:51095
type: Species
name: TRNT1
initial amount: NaN
boundary condition: true
is: Q96Q11
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM ksi pre11 g
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
constant: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 11
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM CE5160 r
has only substance units: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
initial amount: NaN
is: CHEBI:57923
constant: false
name: 3-oxo-cis-9-octadecenoyl-CoA
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaR r1612
reversible: true
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_e8ec4645_ccdf_4954_a6a2_71ba1ba49ea2
name: GGT5
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:2687
initial amount: NaN
is: P36269

metaM L2aadp6sa c
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: CHEBI:17917
is: HMDB01263
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: L-allysine

http://identifiers.org/biomodels.db/MODEL1310110047#_bd929ed8_854e_47bc_ad2b_ceca2d72f82e
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
name: B3GNT2
is: SBO:0000252
is encoded by: hsa:10678
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_4124083c_c3f3_4a68_84f3_16237f3cab5b
constant: false
is encoded by: hsa:471
is: P31939
boundary condition: true
type: Species
initial amount: NaN
name: ATIC
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
type: Species
name: VI2Fuc-nLc6
has only substance units: false
boundary condition: false
is: CHEBI:61648
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0

metaR C16DCc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_8a90a062_bffa_4c16_9086_e82cf5cbbefe
is encoded by: hsa:6510
name: SLC1A5
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: Q15758

metaM m3mpdol U c
constant: false
initial concentration: 1.0
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
is: SBO:0000247
has only substance units: false
is: CHEBI:37632
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_586690f0_62b3_448b_af92_75ed52a63340
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7360
name: UGP2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_ca112b04_3d69_4995_87c9_446a131b5518
name: DPAGT1
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q9H3H5
is encoded by: hsa:1798
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_d47d7c24_3e90_4c12_994e_9b2825795a97
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4705
type: Species
has only substance units: false
constant: false
name: NDUFA10
boundary condition: true
is: O95299

metaR r1611
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_9d30668a_1752_45a0_8f20_7534c7c63375
has only substance units: false
is: SBO:0000252
boundary condition: true
name: FDPS
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: P14324
is encoded by: hsa:2224

metaM HC00319 m
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
initial amount: NaN
is: CHEBI:30794
initial concentration: 1.0
name: Malonate
boundary condition: false

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB06321
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaR 5ADTSTSTERONEtr
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110047#
name: 5 alpha dihydrotesterone intracellular transport
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185

metaM gumgchol e
name: guar gum-glycocholate complex
boundary condition: false
has only substance units: false
is: HMDB00759
type: Species
is: http://identifiers.org/pubchem.compound/102468
constant: false
is: SBO:0000247
notes: FORMULA: C2760026H5060043NO2530006 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: C02155

http://identifiers.org/biomodels.db/MODEL1310110047#_d5ab031f_5f78_4ea8_b035_5ef213a794da
is encoded by: hsa:81539
constant: false
is: Q9H2H9
name: SLC38A1
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_d280e31e_4d0b_4cec_af94_f4e0dbe972cd
is: SBO:0000252
name: _D87002_1_m
initial amount: NaN
constant: false
is encoded by: hsa:D87002
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_43682c86_c84a_4d09_a307_870b7ba25ed9
is encoded by: hsa:2645
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: GCK
constant: false
initial concentration: NaN
has only substance units: false

metaM CE5854 e
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:27485
initial concentration: 1.0
constant: false
is: HMDB02710
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
name: gama-CEHC-glucuronide

metaR r1614
type: Reaction
fast: false
reversible: true
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
is: SBO:0000185

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR PItx
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
product: MODEL1310110047#
name: Phosphate transporter, peroxisome
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM Ser Gly Ala X Gly l
name: protein-linked serine residue (glycosaminoglycan attachment site)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: XH CHARGE: 0
is: CHEBI:36005
initial amount: NaN
is: HMDB02183

http://identifiers.org/biomodels.db/MODEL1310110047#_aba5e422_4831_4dc6_8d60_7aceee3440ac
name: GLRX
is: SBO:0000252
constant: false
is encoded by: hsa:2745
type: Species
is: P35754
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaR ALCD21 L
kinetic law: MODEL1310110047#
name: alcohol dehydrogenase (L-1,2-propanediol)
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reversible: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.99.24

http://identifiers.org/biomodels.db/MODEL1310110047#_34dc694d_bde8_4932_9cac_d708e787b501
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PRDX2
is encoded by: hsa:7001
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_debe67b2_bde7_4214_becb_1dbb909e4da7
name: _FLJ44968_1_m
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:FLJ44968
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR HIVCRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_f6a69745_26b5_4a84_8dac_29cf24a49d66
has only substance units: false
boundary condition: true
is encoded by: hsa:4710
is: O95168
is: SBO:0000252
constant: false
initial amount: NaN
name: NDUFB4
type: Species
initial concentration: NaN

metaR ACGAMPM
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.4.2.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
fast: false
modifier: MODEL1310110047#
type: Reaction
name: phosphoacetylglucosamine mutase
reversible: true
reactant: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#

metaR r0400
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
kinetic law: MODEL1310110047#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reactant: MODEL1310110047#
is described by: ECO:0000000

metaM 3hodcoa m
is: SBO:0000247
name: (S)-3-Hydroxyoctadecanoyl-CoA
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
type: Species
constant: false

metaR C16DCe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR MM5cg
reversible: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaM hexdtrcoa m
name: 7,10,13-hexadecatrienoylcoa
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB02288
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM adn c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:16335
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: HMDB00050
is: C00212

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_1c04f7b3_b7ca_486a_968d_44b107086de8
is: Q8N3E9
is encoded by: hsa:113026
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: PLCD3
is: SBO:0000252
constant: false

metaR r1613
is described by: ECO:0000000
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR GASNASEly
is: SBO:0000176
product: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
type: Reaction
name: glycosylasparaginase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110047#_99683b6e_ebcb_48c0_b1bf_6242120fd91b
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI926493
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _AI926493_1_m

metaM mercplac c
type: Species
name: 3-Mercaptolactate
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: C05823
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8118
has only substance units: false
is: HMDB02127
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_80f4bd4b_d8d8_4be2_a3e8_271d8f4e8ad5
is: P51841
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:2986
name: GUCY2F

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR SPHS1Pte
name: sphingosine-1-phosphate transport
reversible: true
kinetic law: MODEL1310110047#
fast: false
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is described by: ECO:0000000
reactant: MODEL1310110047#
is: SBO:0000185

metaR ACNAMPH
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110047#
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110047#

metaM tethex3coa x
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/47205478
constant: false
is: HMDB06243
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial concentration: 1.0
is: C16168
boundary condition: false
name: tetracosahexaenoyl coenzyme A
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_d8f9847a_5fff_41b7_aea4_32f3f398c5b4
constant: false
is: SBO:0000252
is: Q5JWV8
name: ACSL4
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2182
type: Species

metaR HAtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: hyaluronan transport, extracellular to lysosome
reversible: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_7a49d877_2908_4e5a_a5f8_f753aea92356
name: RDH8
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:50700
is: Q9NYR8

http://identifiers.org/biomodels.db/MODEL1310110047#_d5a00331_92c7_4806_97c0_0f82b78568d7
initial amount: NaN
boundary condition: true
name: SLC37A4
type: Species
is encoded by: hsa:2542
is: A8K0S7
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_f5ccde6f_3fa7_45b0_b09a_85a16e0e4b50
boundary condition: true
is encoded by: hsa:978
has only substance units: false
constant: false
name: CDA
is: P32320
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaR FAOXC7C5m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaR r0829
is: SBO:0000185
reactant: MODEL1310110047#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction

metaM 4hphac e
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00020
name: 4-hydroxyphenylacetate
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species
is: CHEBI:48999

metaR RE0453C
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is: SBO:0000176
name: RE0453
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaR r1761
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
name: Y+LAT2 Utilized transport
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_e6571a28_f10a_4102_9d29_c0febbba66a5
type: Species
name: PDE9A
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5152
has only substance units: false

metaM hexe3coa m
is: HMDB06522
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: 3-hexenoylcoa
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_531c5fef_7409_404f_ac04_e5441fa362ca
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P27987
name: ITPKB
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3707
type: Species
constant: false

metaM HC02206 e
initial amount: NaN
has only substance units: false
is: CHEBI:57399
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin C1(1-)
constant: false
boundary condition: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686

metaR RBFK
product: MODEL1310110047#
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110047#
name: riboflavin kinase
is version of: http://identifiers.org/ec-code/2.7.1.26
is described by: ECO:0000269
reactant: MODEL1310110047#

metaM dc2coa m
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: trans-Dec-2-enoyl-CoA
has only substance units: false
is: CHEBI:61406
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275

metaR DMNONCRNCPT2
is: SBO:0000176
product: MODEL1310110047#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110047#
name: DMNONCRNCPT2
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_9b164470_e857_4908_8978_1da3f1b7c651
name: SLC13A4
is: SBO:0000252
is encoded by: hsa:26266
constant: false
initial amount: NaN
is: Q9UKG4
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaR GLNCYSNaEx
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
type: Reaction
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_d04549c1_0ae8_4541_8133_e707aa9917e4
constant: false
is: O95864
boundary condition: true
is encoded by: hsa:9415
initial amount: NaN
type: Species
is: SBO:0000252
name: FADS2
has only substance units: false
initial concentration: NaN

metaM oaa x
is: SBO:0000247
has only substance units: false
name: Oxaloacetate
type: Species
is: HMDB00223
constant: false
initial concentration: 1.0
is: CHEBI:16452
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: C00036
initial amount: NaN

metaM s2l2n2m2m l
is: SBO:0000247
name: de-Fuc form of PA6 (w/o peptide linkage)
is: HMDB00573
is: CHEBI:30825
notes: FORMULA: C84H136N6O62 CHARGE: -2
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
has only substance units: false

metaM pan4p m
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
name: pantetheine 4'-phosphate(2-)
is: HMDB01416

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_69758319_ffec_49aa_ad35_da7eb6f5b800
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: UEVLD
boundary condition: true
type: Species
is: Q8IX04
is encoded by: hsa:55293
has only substance units: false
constant: false

metaR RE3270C
is: SBO:0000176
reactant: MODEL1310110047#
reversible: true
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: RE3270

metaM apoC m
boundary condition: false
name: Apocarboxlase (no lys residue)
is: CHEBI:32551
is: SBO:0000247
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: HMDB00182
type: Species
initial concentration: 1.0
constant: false
has only substance units: false

metaM hdd2crn c
has only substance units: false
is: HMDB06317
initial concentration: 1.0
is: SBO:0000247
constant: false
name: trans-Hexadec-2-enoyl carnitine
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+

http://identifiers.org/biomodels.db/MODEL1310110047#_36c6b136_4f3c_4989_a3fb_4e4667a7b29e
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: E9PDW4
is encoded by: hsa:6557
is: SBO:0000252
boundary condition: true
name: SLC12A1

metaR EX cysam LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cysam
type: Reaction

metaR r0403
is: SBO:0000176
fast: false
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#

metaR r1610
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_49538fa8_dff6_43aa_8902_5d91007d9cb3
initial amount: NaN
type: Species
has only substance units: false
name: GART
initial concentration: NaN
is encoded by: hsa:2618
is: SBO:0000252
boundary condition: true
constant: false
is: P22102

metaM HC02206 c
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: prostaglandin C1(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
has only substance units: false
is: CHEBI:57399
boundary condition: false

metaM taur x
is: HMDB00251
boundary condition: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
initial amount: NaN
constant: false
initial concentration: 1.0
name: taurine
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15891

metaR DHCHOLESTANATEtm
product: MODEL1310110047#
is: SBO:0000185
reversible: true
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110047#
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_166d8316_c595_4eff_bba7_7c8b3803be7b
is: P31350
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6241
initial concentration: NaN
name: RRM2

metaR RE2759X
product: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.99.4
name: RE2759
type: Reaction
kinetic law: MODEL1310110047#
reversible: true
fast: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:

metaR MAOX
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110047#
name: Methylamine oxidase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false

metaR MDH
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.37
type: Reaction
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: malate dehydrogenase
reversible: true
product: MODEL1310110047#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:Biochemical
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_762beef2_575a_483b_a8d0_ba76f39ae01d
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: RBAK
is: Q9NYW8
constant: false
is encoded by: hsa:57786
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_049f2949_ead6_48ae_89ad_f4ceb6e622d0
boundary condition: true
is encoded by: hsa:5293
type: Species
name: PIK3CD:PIK3R3
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
has only substance units: false
has part: Q92569
has part: A7E2E0
constant: false
is encoded by: hsa:8503

http://identifiers.org/biomodels.db/MODEL1310110047#_9b7e59a5_7ebf_4bbe_9d03_1667475df0d6
initial concentration: NaN
is encoded by: hsa:5335
name: PLCG1
is: P19174
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR FK
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.52
fast: false
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Fucokinase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_e7845041_9222_4323_a50a_a0d825c96ce3
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: RRM2B
boundary condition: true
is: Q7LG56
initial amount: NaN
is encoded by: hsa:50484

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR NACHEX24ly
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110047#_435796dc_ab06_4d58_9fca_91ae6d5d79ce
boundary condition: true
is encoded by: hsa:8560
constant: false
name: DEGS1
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR FAOXC22C20x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22-->C20)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_0c73d1e2_9b94_49ea_82a5_87bd24fa1a7f
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: NME1:NME2
has only substance units: false
is encoded by: hsa:4830
boundary condition: true

metaM leuktrF4 e
is: HMDB06465
is: CHEBI:27491
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: leukotriene F4
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1

metaR PCHOL HSter
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
name: phosphatidylcholine scramblase
is: SBO:0000185

metaR RE3301C
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: true
name: RE3301
fast: false
type: Reaction
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4

metaR PTDCACRNt
reversible: false
product: MODEL1310110047#
reactant: MODEL1310110047#
name: pentadecanoate transport into the mitochondria
modifier: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
fast: false
is: SBO:0000185

metaR GLYLEUHYDROc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Glycylleucine in the small intestine for cellular uptake
type: Reaction

metaM sbcoa c
boundary condition: false
is: HMDB00791
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: C02838
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa
has only substance units: false
initial concentration: 1.0

metaR GALASE11ly
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: false

metaR G14T7g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110047#

metaR DRIBt
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
name: deoxyribose transport via diffusion
is: SBO:0000185
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#

metaR MMSAD3m
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
is described by: ECO:0000269
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial

metaM apoC c
has only substance units: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
is: CHEBI:33190
initial concentration: 1.0
constant: false
type: Species
name: Apocarboxlase (no lys residue)
is: HMDB11111
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_eaeb3716_4fac_403a_9ced_5556b07e1878
constant: false
name: ENTPD8
has only substance units: false
is encoded by: hsa:377841
is: Q5MY95
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR THRALANaEx
is: SBO:0000185
reactant: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)

metaR GALASE10ly
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110047#
is described by: ECO:0000000

metaR PItn
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
name: phosphate transport, nuclear

metaM 10fthf c
initial concentration: 1.0
boundary condition: false
is: C00234
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
constant: false
initial amount: NaN
is: HMDB00972
name: 10-Formyltetrahydrofolate
has only substance units: false
is: SBO:0000247

metaM ksi deg13 l
is: HMDB00812
type: Species
name: keratan sulfate I, degradation product 13
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16953
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
boundary condition: false
has only substance units: false

metaR MALTSULtm
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
name: Malate:thiosulfate antiport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110047#_8477cd67_6c20_4342_9ac8_5d426edaa6a5
boundary condition: true
type: Species
is encoded by: hsa:3251
has only substance units: false
is: SBO:0000252
name: HPRT1
constant: false
initial amount: NaN
initial concentration: NaN
is: P00492

metaM pi e
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:43474
boundary condition: false
is: SBO:0000247
name: hydrogenphosphate
initial concentration: 1.0

metaR ELAIDCRNt
product: MODEL1310110047#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_16f1ec06_67ec_4fd9_8c53_122c966a287d
has only substance units: false
name: SLC2A2
is encoded by: hsa:6514
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: P11168

metaM phyt e
type: Species
constant: false
is: HMDB00801
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37257
name: phytanate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607

http://identifiers.org/biomodels.db/MODEL1310110047#_a29e12bc_0ddc_4cd8_a8b9_f0b9b90be5b4
boundary condition: true
has part: E5KS60
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:8803
constant: false
type: Species
initial concentration: NaN
name: SUCLG1:SUCLA2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8f9435a1_a7e0_44c6_b3f4_5bc2ecdab306
name: INPP5B
is: SBO:0000252
is: P32019
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:3633
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_82b38a70_5860_4ce6_a41b_e0f737c32b57
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: CHST2
is encoded by: hsa:9435
type: Species
boundary condition: true
initial amount: NaN
is: Q9Y4C5

metaR FAOXC163C164Gm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR FAOXC163C164x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_054c8f40_5222_4b97_b738_67867b9f0465
name: RRM2
type: Species
boundary condition: true
has only substance units: false
is: P31350
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6241

metaM pap g
is: CHEBI:58343
is: HMDB00061
type: Species
is: SBO:0000247
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_df22f20b_5934_40d0_ab7a_e5bc37e695f9
boundary condition: true
is encoded by: hsa:AI469183
name: _AI469183_1_x
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR r0119
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110047#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
fast: false
product: MODEL1310110047#
type: Reaction

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM xol27oh r
is: HMDB02103
is: CHEBI:17703
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
name: 26-hydroxycholesterol
type: Species
initial concentration: 1.0
has only substance units: false

metaM 4hphac c
has only substance units: false
is: HMDB00020
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species
is: CHEBI:48999
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 4-hydroxyphenylacetate

metaM acetone m
type: Species
is: SBO:0000247
constant: false
is: CHEBI:15347
name: acetone
has only substance units: false
is: HMDB01659
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaR C30CPT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaM cyan c
is: CHEBI:18407
constant: false
is: HMDB02084
name: hydrogen cyanide
initial concentration: 1.0
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

metaR r0512
is: SBO:0000176
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110047#
product: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is described by: ECO:0000000
fast: false
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
type: Reaction
reactant: MODEL1310110047#

metaR UMPK7n
name: UMP kinase (dGTP),nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_346edf97_96fe_45c1_af33_0c079a95ebfe
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: _286297_1_c
type: Species
is encoded by: hsa:286297
initial amount: NaN

metaR B3GNT31g
reactant: MODEL1310110047#
reversible: false
product: MODEL1310110047#
fast: false
type: Reaction
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110047#_594d1c31_5a75_40ab_be85_58159bb45f7e
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5723
name: PSPH
constant: false
is: P78330

http://identifiers.org/biomodels.db/MODEL1310110047#_4bca346a_d094_456e_8196_8d36e1fb3a70
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PDE9A
is encoded by: hsa:5152
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaM acmana c
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
type: Species
is: HMDB01129
boundary condition: false
is: SBO:0000247
is: CHEBI:17122
name: N-acetyl-D-mannosamine

metaM 10fthf e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
is: HMDB00972
has only substance units: false
is: CHEBI:57454
boundary condition: false
constant: false
type: Species

metaM dcsptn1crn m
boundary condition: false
is: HMDB06321
constant: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN
type: Species
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM 3thexddcoacrn c
boundary condition: false
is: HMDB02014
initial amount: NaN
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C23H41NO5 CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_00fdee0a_6735_461c_b615_bc923b284347
boundary condition: true
is encoded by: hsa:56922
has part: Q96RQ3
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000297
initial concentration: NaN
type: Species
has part: Q9HCC0
name: MCCC1:MCCC2
is encoded by: hsa:64087

http://identifiers.org/biomodels.db/MODEL1310110047#_c263520c_e6ae_4b47_8794_4544d649e823
is: O00764
is encoded by: hsa:8566
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: PDXK
is: SBO:0000252
initial concentration: NaN

metaR CYSGLNNaEx
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110047#
modifier: MODEL1310110047#

metaR LAPCOAe
fast: false
reversible: false
name: LAPCOAe
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_e5947ce9_2736_4895_9123_d9004d977d9f
is encoded by: hsa:50484
has only substance units: false
is: Q7LG56
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: RRM2B
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_c61ba128_7306_4212_a011_db81e13de63d
is encoded by: hsa:3000
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q02846
constant: false
name: GUCY2D
is: SBO:0000252

metaM pi c
is: HMDB00973
has only substance units: false
type: Species
is: C00009
is: CHEBI:43474
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
constant: false
initial amount: NaN
name: hydrogenphosphate
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_578b1485_a80f_456b_abd7_1f6e33a96dcf
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:10195
name: ALG3
constant: false
initial concentration: NaN

metaM 3ivcoa m
initial amount: NaN
is: HMDB06870
constant: false
name: 3-hydroxyisovalerylcoa
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C05998
initial concentration: 1.0
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/11966188
type: Species

metaR S6TASE2ly
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110047#
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_b3eb6282_b472_4f7d_8967_02dcd1649db9
is: P51648
initial concentration: NaN
name: ALDH3A2
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:224

metaR THYOXt
kinetic law: MODEL1310110047#
reversible: true
type: Reaction
fast: false
product: MODEL1310110047#
is: SBO:0000185
name: T4 transport via bicarbonate countertransport
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110047#

metaR MTHFD2
modifier: MODEL1310110047#
name: methylenetetrahydrofolate dehydrogenase (NAD)
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110047#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110047#

metaR FACOAL2251
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
product: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_262856f4_4398_44aa_aad2_5c431375fd33
is: SBO:0000252
name: _T83654_1_c
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:T83654
constant: false

metaR BHBt
is described by: ECO:0000000
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reversible: true
is: SBO:0000185
fast: false
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110047#
type: Reaction

metaR DGTPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: dGTP diffusion in nucleus
reversible: true
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_069f6111_b927_4040_a1bc_285605b67319
boundary condition: true
has only substance units: false
is encoded by: hsa:586
type: Species
constant: false
is: P54687
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: BCAT1

metaM cyan e
is: HMDB02084
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: hydrogen cyanide
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326

metaM tmndnccrn c
is: CHEBI:0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
is: HMDB00235
is: SBO:0000247
is: C00378
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Timnodonyl carnitine

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r0267
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.1.9
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_32240f34_40ed_49f6_8451_0c5b3cf70b1b
is encoded by: hsa:113452
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q969K7
constant: false
has only substance units: false
name: TMEM54
is: SBO:0000252

metaR LAPCOAl
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000304
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
fast: false
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
name: lysosomal acid phosphorylase (CoA)

http://identifiers.org/biomodels.db/MODEL1310110047#_772fecae_9078_4cf2_bc64_6063576e81f8
is: SBO:0000252
type: Species
is encoded by: hsa:10164
name: CHST4
initial concentration: NaN
constant: false
boundary condition: true
is: Q8NCG5
initial amount: NaN
has only substance units: false

metaM asp D x
name: D-aspartate(1-)
is: CHEBI:29990
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: HMDB06483
type: Species
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_9094ea5e_35ca_4e93_ad26_124c1f7a18a5
boundary condition: true
is: SBO:0000252
is: Q9H2X9
initial concentration: NaN
is encoded by: hsa:57468
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: SLC12A5

http://identifiers.org/biomodels.db/MODEL1310110047#_aff59411_9df4_4e3b_a5d2_48e200a64ef3
is encoded by: hsa:2879
boundary condition: true
is: SBO:0000252
name: GPX4
type: Species
initial amount: NaN
constant: false
is: P36969
initial concentration: NaN
has only substance units: false

metaM hs deg18 l
initial amount: NaN
type: Species
is: CHEBI:17180
name: heparan sulfate, degradation product 18
boundary condition: false
constant: false
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: SBO:0000247
is: HMDB01352
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_e73ab09d_0a68_4a47_92e9_d0cd5066f679
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q16739
type: Species
name: UGCG
is encoded by: hsa:7357

http://identifiers.org/biomodels.db/MODEL1310110047#_e802fb56_4945_4316_8da1_6be97904e8b5
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI990637
initial amount: NaN
has only substance units: false
type: Species
name: _AI990637_1_x
initial concentration: NaN
constant: false

metaR FACOAL2252
reactant: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
name: fatty-acid--CoA ligase
is described by: ECO:0000269
modifier: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaM lald D c
is: CHEBI:17167
initial concentration: 1.0
name: (R)-lactaldehyde
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
constant: false
is: SBO:0000247
is: HMDB06458

http://identifiers.org/biomodels.db/MODEL1310110047#_18514278_4f7e_4d89_a4a0_f0c5f77bb0e5
name: CYP2C19
is: SBO:0000252
is encoded by: hsa:1557
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: P33261
boundary condition: true
has only substance units: false

metaR r0268
is: SBO:0000176
product: MODEL1310110047#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
reactant: MODEL1310110047#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.3.2

metaM 3thexddcoacrn e
boundary condition: false
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H41NO5 CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
is: HMDB02014

metaR GTHPm
is version of: http://identifiers.org/ec-code/1.11.1.12
name: glutathione peroxidase, mitochondria
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
reversible: true
product: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_662d36e2_72c6_4ce0_b60b_24460b460a3a
initial concentration: NaN
is: P15104
name: GLUL
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2752
boundary condition: true

metaM adn e
name: Adenosine
type: Species
constant: false
initial concentration: 1.0
is: HMDB00050
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: CHEBI:16335
has only substance units: false
boundary condition: false
is: C00212

metaM prostge2 c
is: SBO:0000247
is: CHEBI:606564
type: Species
constant: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
has only substance units: false
initial amount: NaN
is: HMDB01220
name: prostaglandin E2(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_07e1b2b7_b1e1_4506_8068_8c88f3c53eee
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1376
type: Species
name: CPT2
is: SBO:0000252
initial amount: NaN
is: P23786
boundary condition: true

metaR XOLDIOLONEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110047#

metaR VALt4
is: SBO:0000185
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is described by: ECO:0000304
name: L-valine transport in via sodium symport
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR H7 TAer
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
is described by: ECO:0000000
reactant: MODEL1310110047#
name: H7' transamidase, endoplasmic reticulum
reversible: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176

metaM pap c
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
is: HMDB00061
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_cdf71299_974f_420b_84ab_3afe1eb49526
initial concentration: NaN
has only substance units: false
name: TXNRD2
type: Species
boundary condition: true
is encoded by: hsa:10587
is: SBO:0000252
constant: false
initial amount: NaN

metaM leuktrF4 c
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:27491
is: HMDB06465
name: leukotriene F4
is: SBO:0000247

metaR r0936
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110047#

metaR CSEPASEly
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110047#
reversible: false

metaR DALAt2r
is: SBO:0000185
fast: false
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000304
name: D-alanine transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reversible: true
modifier: MODEL1310110047#
reactant: MODEL1310110047#

metaM ksi deg10 l
is: SBO:0000247
is: CHEBI:16953
name: keratan sulfate I, degradation product 10
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
constant: false
is: HMDB00812
initial amount: NaN
initial concentration: 1.0

metaM L2aadp6sa m
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17917
name: L-allysine
is: HMDB01263
initial concentration: 1.0
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076

http://identifiers.org/biomodels.db/MODEL1310110047#_27403b4c_40ec_424c_9703_08b55bb7bcbd
initial concentration: NaN
is: SBO:0000297
has part: Q9NS82
is encoded by: hsa:56301
is encoded by: hsa:6520
constant: false
has part: P08195
has only substance units: false
name: SLC7A10:SLC3A2
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_6b6d828f_c36d_4222_bc7d_f189215b289c
boundary condition: true
constant: false
initial amount: NaN
is: Q92947
has only substance units: false
type: Species
is encoded by: hsa:2639
name: GCDH
initial concentration: NaN
is: SBO:0000252

metaR DURIt
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110047#
name: deoxyuridine transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#

metaM phyt c
is: CHEBI:37257
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00801
name: phytanate
type: Species

metaM xol27oh m
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: 26-hydroxycholesterol
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
is: CHEBI:17703

metaR r0937
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
name: Transport reaction
product: MODEL1310110047#
reversible: true

metaR DAG HSter
fast: false
is: SBO:0000185
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: diacylglycerol ER export

metaM prostge2 e
is: SBO:0000247
is: CHEBI:606564
type: Species
constant: false
initial amount: NaN
is: HMDB01220
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
has only substance units: false
initial concentration: 1.0
name: prostaglandin E2(1-)

metaR CO2ter
reactant: MODEL1310110047#
name: CO2 endoplasmic reticular transport via diffusion
reversible: true
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaR O2ter
name: O2 transport, endoplasmic reticulum
reversible: true
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR RE0453N
fast: false
name: RE0453
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

metaM thcrm hs g
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
name: trihexosyl ceramide
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:24636

metaR CYTDtm
is: SBO:0000185
is described by: ECO:0000269
fast: false
reversible: true
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
modifier: MODEL1310110047#
name: cytidine facilated transport in mitochondria

metaM Rtotal e
notes: FORMULA: CO2FULLR CHARGE: -1
type: Species
is: C00255
is: CHEBI:3554
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: R total
is: SBO:0000247
is: HMDB00244

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR S2L2FN2M2MASNt
reactant: MODEL1310110047#
product: MODEL1310110047#
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
name: s2l2fn2m2masn transport, Golgi to extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110047#
is: SBO:0000185

metaR B3GNT312g
product: MODEL1310110047#
fast: false
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110047#
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176

metaR CSNATr
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
reversible: true
kinetic law: MODEL1310110047#
name: carnitine O-acetyltransferase
is described by: ECO:0000000
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_54b30ccc_df8e_4a21_9ed0_a27eb6afb703
is encoded by: hsa:8528
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: DDO
is: Q99489
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_a9d66276_6ac4_46ee_bc11_e706050d5d10
is: Q9NZL9
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:27430
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: MAT2B

metaR HESTRATRIOLte
is described by: ECO:0000000
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
name: hydroxylated estrogen derivative transport
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ

metaR PCt
is described by: ECO:0000269
kinetic law: MODEL1310110047#
is: SBO:0000185
name: phosphatidylcholine transporter
modifier: MODEL1310110047#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.6.3.44
reactant: MODEL1310110047#

metaR ALAt2r
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
name: L-alanine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185

metaM 5aop c
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
name: 5-Amino-4-oxopentanoate
is: CHEBI:17549
has only substance units: false
is: C00430
is: HMDB01149
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR FTHFL
name: Formate-tetrahydrofolate ligase
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110047#
modifier: MODEL1310110047#

metaR GNDer
product: MODEL1310110047#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
kinetic law: MODEL1310110047#
reversible: false
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false
is described by: ECO:0000000

metaR FAOXC181C161m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaM 10fthf m
boundary condition: false
type: Species
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247
constant: false

metaR FAOXC204184m
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110047#_ae7d12ba_0e61_49af_a90e_cacdb672cd66
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:9377
constant: false
initial amount: NaN
initial concentration: NaN
name: COX5A
is: P20674
is: SBO:0000252

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM acgam c
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine
boundary condition: false
is: CHEBI:17411
constant: false
is: HMDB00215
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_9b49fb77_211c_497f_9018_50e3960c3503
is: Q92523
initial concentration: NaN
name: CPT1B
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:1375
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_67fd7f53_36a3_47ca_b7c0_d31393903317
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P13073
has only substance units: false
is encoded by: hsa:1327
name: COX4I1

metaM hdd2crn m
constant: false
initial concentration: 1.0
name: trans-Hexadec-2-enoyl carnitine
type: Species
initial amount: NaN
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
is: HMDB06317
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM CE2705 c
type: Species
is: SBO:0000247
constant: false
is: CHEBI:36781
boundary condition: false
name: quinonoid dihydrobiopterin
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
has only substance units: false

metaM HC01401 m
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
is: SBO:0000247
is: CHEBI:27668
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
constant: false
boundary condition: false
initial amount: NaN

metaR IZPN
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
name: Imidazolonepropionase
type: Reaction
product: MODEL1310110047#

metaM lneldc e
constant: false
is: SBO:0000247
type: Species
is: HMDB06270
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial concentration: 1.0
boundary condition: false
name: linoelaidic acid (all trans C18:2)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_733b92ff_1acd_4288_9bf5_15a8d01ae5e7
type: Species
has only substance units: false
is encoded by: hsa:9162
constant: false
name: DGKI
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O75912

metaR DGK2m
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
is: SBO:0000176

metaM hs deg22 l
boundary condition: false
type: Species
initial amount: NaN
is: HMDB02704
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:21338
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
notes: FORMULA: C37H56NO35S CHARGE: -3

metaR GLYCTO1p
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.3.15
type: Reaction
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110047#
is described by: ECO:0000269
name: Glycolate oxidase, peroxisome
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR CSNATp
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110047#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
modifier: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_d0e7d7c9_e3d6_4003_844e_1394da7a7f88
is encoded by: hsa:124583
is: Q8WVQ1
initial concentration: NaN
type: Species
is: SBO:0000252
name: CANT1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaR ABTD
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
name: L-arabinitol 4-dehydrogenase
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000
reversible: true

metaM taur c
is: CHEBI:3544
boundary condition: false
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00245
name: Taurine
type: Species
initial amount: NaN

metaR SBTR
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110047#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
name: D-sorbitol reductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:

metaM trdrd c
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Reduced thioredoxin
is: C00342
boundary condition: false
has only substance units: false
type: Species

metaM oaa c
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00223
is: C00036
is: SBO:0000247
notes: FORMULA: C4H2O5 CHARGE: -2
name: Oxaloacetate
type: Species
is: CHEBI:3338

metaR ESTRADIOLt
name: estradiol transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM co e
is: HMDB01361
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17245
has only substance units: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
is: SBO:0000247
name: carbon monoxide
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
type: Reaction
name: blood group intracellular transport
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_4bbc21ed_2ddd_44b9_a4be_9eee8c347585
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110047#_153f0160_75d7_4b5b_bdd3_82d524dc2ba1
initial amount: NaN
type: Species
boundary condition: true
is: Q9GZX3
is: SBO:0000252
name: CHST6
is encoded by: hsa:4166
initial concentration: NaN
has only substance units: false
constant: false

metaM dd2coa m
initial concentration: 1.0
is: HMDB03712
is: CHEBI:57330
name: trans-dodec-2-enoyl-CoA(4-)
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_674dce4e_157a_43c7_86f2_a8c96f341cf7
is: SBO:0000252
initial concentration: NaN
is: O15056
name: SYNJ2
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8871
type: Species
has only substance units: false

metaM acetone e
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
is: HMDB01659
type: Species
name: acetone
constant: false
initial amount: NaN
is: CHEBI:15347
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR ICDHyrm
kinetic law: MODEL1310110047#
fast: false
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
modifier: MODEL1310110047#
name: Isocitrate dehydrogenase (NADP+)

metaR FAOXC226C205m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM dcholcoa c
type: Species
boundary condition: false
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
initial amount: NaN
is: CHEBI:28701
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
is: HMDB06292

metaR CH25H
is: SBO:0000176
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.99.38
modifier: MODEL1310110047#
reactant: MODEL1310110047#
name: cholesterol 25-hydroxylase

metaM HC00591 c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16769
name: 2-oxoglutaramate
type: Species

metaM tddedicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: trans3,6dodecadienoylcoa
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280771

metaR AHCYStr
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
is: SBO:0000185
name: S-Adenosyl-L-homocysteine intracellular diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false

metaR PRODt2r
reversible: true
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: D-proline reversible transport via proton symport
modifier: MODEL1310110047#
fast: false

metaR RE1836X
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: true
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
modifier: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
fast: false
name: RE1836
type: Reaction

metaM lneldc c
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial concentration: 1.0
is: HMDB06270
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: linoelaidic acid (all trans C18:2)

metaM 3ivcoa c
is: C05998
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06870
name: 3-hydroxyisovalerylcoa
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/11966188

http://identifiers.org/biomodels.db/MODEL1310110047#_828a453e_67e6_48a5_85df_ad338b9230c1
is: SBO:0000252
constant: false
is: B4DK61
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:51
boundary condition: true
initial concentration: NaN
name: ACOX1

metaR STRDNCt
product: MODEL1310110047#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110047#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_64aab096_f7ea_4d90_9d76_1ca61efaf253
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:728441
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
name: GGT2

metaM HC00695 m
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: S-Succinyldihydrolipoamide
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
is: CHEBI:17432
boundary condition: false

metaR PAPStg
product: MODEL1310110047#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: 3'-Phosphoadenylyl sufate Golgi transport
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
is: SBO:0000185

metaM taur e
is: CHEBI:3544
is: HMDB00251
constant: false
boundary condition: false
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Taurine
initial amount: NaN

metaR GALU
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reversible: true
type: Reaction
name: UTP-glucose-1-phosphate uridylyltransferase
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.7.9
reactant: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_230321f6_98a5_4d45_93af_df0aef83883e
initial amount: NaN
is: Q1ET61
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6818
name: SULT1A3
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM CE4872 c
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15748
is: HMDB00127
boundary condition: false

metaR EX ivcrn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_13e959d8_c396_46d3_a6e6_0fd23ecffc28
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
constant: false
name: PDE9A
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR GAL3ST11
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.8.2.11
modifier: MODEL1310110047#
reversible: false
name: Galactosylceramide sulfotransferase
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
reactant: MODEL1310110047#
is: SBO:0000176

metaM co c
is: SBO:0000247
name: carbon monoxide
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01361
is: CHEBI:17245

metaR NACHEX19ly
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110047#_b9d9717b_c829_46bd_9d3f_fefc0431691e
boundary condition: true
has only substance units: false
name: SLC25A13
constant: false
is: SBO:0000252
is encoded by: hsa:10165
is: Q9UJS0
initial amount: NaN
initial concentration: NaN
type: Species

metaR NADPHtru
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110047#
fast: false
name: NADPH transporter, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110047#

metaM arachdcoa x
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB06523
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN

metaR S6T13g
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110047#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110047#
reversible: false

metaR r0502
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
reactant: MODEL1310110047#

metaR ASPDxt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: D-aspartate transport, peroxisomal
product: MODEL1310110047#
is: SBO:0000185
fast: false
reactant: MODEL1310110047#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_b7df221d_080b_4ad6_a0fc_0c9c2a70f6b0
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:6547
initial concentration: NaN
name: SLC8A3
boundary condition: true
has only substance units: false

metaR C6CRNtcx
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_7536a80c_7887_49d4_ac35_5f5dd02c862d
name: FOLR1
is: SBO:0000252
type: Species
is encoded by: hsa:2348
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaR GALT
modifier: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
name: galactose-1-phosphate uridylyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
type: Reaction

metaM cyan m
boundary condition: false
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
name: hydrogen cyanide
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_0af2e08d_746d_477c_904e_d6cebf116380
is encoded by: hsa:5142
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: Q5TEK5
name: PDE4B
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR GLUTCOADHm
is described by: ECO:0000304
type: Reaction
name: glutaryl-CoA dehydrogenase (mitochondria)
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.99.7
reversible: false
modifier: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_6111cda2_36f5_456d_a495_2b5484b4ad4e
is: SBO:0000297
type: Species
initial concentration: NaN
has part: E9KL44
has only substance units: false
has part: P55084
boundary condition: true
initial amount: NaN
name: HADHA:HADHB
constant: false
is encoded by: hsa:3030
is encoded by: hsa:3032

metaM 3tetd7ecoa c
has only substance units: false
is: HMDB05066
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
name: 3-hydroxy tetradecenoyl-7-coa
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaR NAGAlby
reversible: false
name: N-acetylgalactosaminidase, beta-
is described by: ECO:0000000
product: MODEL1310110047#
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
type: Reaction
kinetic law: MODEL1310110047#

metaR FAOXC180
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110047#
product: MODEL1310110047#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR FAOXC4C4DCc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaM didp c
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
constant: false
name: dIDP
initial concentration: 1.0
is: SBO:0000247
is: HMDB03536

metaR RE3006M
is described by: ECO:0000000
name: RE3006
type: Reaction
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110047#

metaM ksi pre33 g
initial concentration: 1.0
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
boundary condition: false
is: SBO:0000247
is: C00130
constant: false
name: keratan sulfate I biosynthesis, precursor 33
initial amount: NaN
type: Species
is: HMDB00175
has only substance units: false
is: CHEBI:58053

metaM 13dpg c
boundary condition: false
constant: false
is: HMDB01270
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3535
name: 3-Phospho-D-glyceroyl phosphate
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
type: Species
has only substance units: false
initial concentration: 1.0
is: C00236
initial amount: NaN
is: CHEBI:57604

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: false
reactant: MODEL1310110047#

metaM m6mpdol U r
initial concentration: 1.0
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:37635
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
constant: false

metaR MTHFCm
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
is described by: ECO:0000269
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_bb0cd6b3_4c94_4cbc_8f58_cc59cdac4c96
type: Species
is: O00219
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:3038
initial concentration: NaN
constant: false
initial amount: NaN
name: HAS3

metaR OCCOAtx
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110047#
fast: false
name: fatty acid intracellular transport
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true

metaM ksi pre3 g
is: HMDB00175
is: C00130
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C93H152N6O67X CHARGE: -1
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 3
is: CHEBI:58053
type: Species

metaR 5ADTSTSTERONEte
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: 5 alpha dihydrotesterone transport

http://identifiers.org/biomodels.db/MODEL1310110047#_d65d0355_3f17_4c38_a41d_cd911bbda6dc
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: Q15738
is encoded by: hsa:50814
is: SBO:0000252
name: NSDHL

metaM 2hexdtetcoa x
initial amount: NaN
type: Species
is: SBO:0000247
name: 2,7,10,13-hexadecatetraenoylcoa
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
constant: false
has only substance units: false

metaM HC00319 c
constant: false
is: CHEBI:30794
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
type: Species
is: SBO:0000247
name: Malonate

metaR FAOXC123C102m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR HEXCCOAtx
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true

metaM Rtotal l
constant: false
has only substance units: false
name: R total
is: CHEBI:52639
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_0944339b_74ee_439a_a38d_0dc87b192b4f
is: SBO:0000252
is encoded by: hsa:5169
boundary condition: true
is: Q308M7
constant: false
name: ENPP3
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR EX doco13ac
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaM hpdcacoa m
boundary condition: false
name: heptadecanoyl coa
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB06497
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_89c6fc2c_2b65_4c41_8a60_c4c1cad30224
is encoded by: hsa:1645
boundary condition: true
is: Q04828
initial concentration: NaN
type: Species
name: AKR1C1
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_db99f79d_f1b4_4a47_a9d0_e6221bedcd78
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O15245
type: Species
has only substance units: false
name: SLC22A1
is: SBO:0000252
is encoded by: hsa:6580
constant: false

metaR r0504
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
modifier: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true

metaR PPCDC
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
product: MODEL1310110047#
name: phosphopantothenoylcysteine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false

metaM tmndnccrn m
name: Timnodonyl carnitine
is: CHEBI:0
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: C00378
is: HMDB00235
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaR CRVNCtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion
product: MODEL1310110047#
fast: false
type: Reaction
is: SBO:0000185

metaR CSNATm
reversible: true
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
type: Reaction
is: SBO:0000176
name: carnitine O-aceyltransferase, mitochondrial
modifier: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110047#
is described by: ECO:0000269

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_5df59d44_1318_47a6_8cc0_637070856b12
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: COX5B
is encoded by: hsa:1329
is: Q53YB7
type: Species
constant: false

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ea00e1e1_12c3_4e86_aad6_6c0889825881
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: RDH14
is: Q9HBH5
is encoded by: hsa:57665

metaR THRD L
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
is: SBO:0000176
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: L-threonine deaminase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.3.1.17
product: MODEL1310110047#

metaM galacglcgalgbside hs e
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
constant: false
name: Gal-GlcNAc-Gal globoside
is: SBO:0000247
boundary condition: false
is: C00124
has only substance units: false
type: Species
is: CHEBI:0
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0

metaR ME2m
is: SBO:0000176
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false
name: malic enzyme (NADP), mitochondrial
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is version of: http://identifiers.org/ec-code/1.1.1.40
is described by: ECO:0000000

metaR O2tn
type: Reaction
kinetic law: MODEL1310110047#
name: O2 nuclear transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_056cf497_2772_49d2_bc22_af3c2f797a2b
is: Q2TU34
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2203
name: FBP1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_abb2cab7_cfd4_49c7_9b70_80fcc5d0142c
is: SBO:0000252
has only substance units: false
name: KL
is encoded by: hsa:9365
boundary condition: true
constant: false
is: Q9UEF7
initial concentration: NaN
type: Species
initial amount: NaN

metaR RE1573M
is: SBO:0000176
name: RE1573
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reversible: true
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

metaR TYRTAm
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.6.1.5
is: SBO:0000176
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
name: tyrosine transaminase, mitochondrial
is described by: ECO:0000269

metaR CYSASNNaEx
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
reversible: false
type: Reaction
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110047#

metaR r1607
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_823e9442_7d89_40df_9328_16c12c691dec
constant: false
is encoded by: hsa:1350
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: COX7C
type: Species
is: P15954
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_81668499_182a_447a_b353_0f8bcb5fd85d
constant: false
initial concentration: NaN
is: O00483
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NDUFA4
is encoded by: hsa:4697

metaM oaa m
is: SBO:0000247
name: Oxaloacetate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00036
is: HMDB00223
constant: false
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: CHEBI:16452

metaR GLCNACPT U
kinetic law: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.15
reversible: false

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaM c6dc x
initial concentration: 1.0
name: adipoyl carnitine
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247
is: HMDB04047
initial amount: NaN
constant: false
is: C14143

metaM dd2coa x
is: CHEBI:57330
initial amount: NaN
is: HMDB03712
name: trans-Dodec-2-enoyl-CoA
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: SBO:0000247
boundary condition: false
constant: false

metaM xylu L c
is: CHEBI:17399
has only substance units: false
name: L-xylulose
type: Species
is: HMDB00751
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial concentration: 1.0
is: SBO:0000247

metaR ACHtn
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
name: Acetylcholin transport, nuclear trhough pores
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it

http://identifiers.org/biomodels.db/MODEL1310110047#_8c411bcd_c4b7_4911_bfcd_f717a2c2579f
type: Species
name: ARSB
is: A8K4A0
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:411

http://identifiers.org/biomodels.db/MODEL1310110047#_16c6d0af_a3df_4846_a61c_4d4bb64f5af0
is encoded by: hsa:3033
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: HADH
initial concentration: NaN
is: Q16836

metaR PAIL45P HStn
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185

metaM 5aop m
boundary condition: false
name: 5-Amino-4-oxopentanoate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01149
type: Species
is: CHEBI:17549
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: C00430
constant: false

metaM galacglcgalgbside hs c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:58343
is: HMDB00061
name: Gal-GlcNAc-Gal globoside
type: Species
boundary condition: false

metaM HC00591 m
initial concentration: 1.0
is: CHEBI:16769
is: SBO:0000247
constant: false
has only substance units: false
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species
boundary condition: false
initial amount: NaN

metaM eipencoa x
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
type: Species
constant: false
name: 2,5,8,11,14-eicosapentaenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790

metaR r1608
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_1126c660_2545_4eb4_92c3_813e0341448a
is encoded by: hsa:5373
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: O15305
constant: false
name: PMM2
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_c3cdd3ff_aff5_46b7_bd31_daaaef334dce
initial amount: NaN
boundary condition: true
name: TALDO1
has only substance units: false
is: SBO:0000252
constant: false
is: P37837
initial concentration: NaN
type: Species
is encoded by: hsa:6888

http://identifiers.org/biomodels.db/MODEL1310110047#_91903a4a_f0b0_487e_93fb_0722ee2bbb11
name: AOC3
initial amount: NaN
is encoded by: hsa:8639
is: Q16853
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaR O2tp
is: SBO:0000185
name: O2 transport, peroxisomal
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
type: Reaction

metaM galacglcgalgbside hs g
is: SBO:0000247
initial concentration: 1.0
name: Gal-GlcNAc-Gal globoside
boundary condition: false
is: CHEBI:26174
type: Species
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110047#_f02572a0_a9af_4ff1_80d4_e7485c915b2b
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: LDHB
is: P07195
initial concentration: NaN
is encoded by: hsa:3945
boundary condition: true
has only substance units: false

metaR r1609
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110047#

metaR ACETONEt2
reversible: true
fast: false
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110047#
modifier: MODEL1310110047#
name: acetone transport via proton symport

metaR 34DHOXPEGOX
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110047#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_9a405a97_af89_46ea_85f8_5380b0839428
type: Species
is: Q5T6L4
is encoded by: hsa:445
name: ASS1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaR FAOXC181C161x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR FAOXC204C205x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_aaa1db8e_c4d1_4d96_8a3d_9d56d0c66a34
has only substance units: false
is: SBO:0000252
name: _BG035985_1_c
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:BG035985
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_739e1b9c_fc96_4f9b_ac47_321e36a08b32
name: _AI620219_1_m
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:AI620219
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_b06d6c84_fb77_48d2_ab3c_884ccf9d710c
is encoded by: hsa:6582
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: O15244
is: SBO:0000252
boundary condition: true
name: SLC22A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f3c45fa8_fa6b_4d85_8127_c2ec72c2c36d
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1109
initial concentration: NaN
initial amount: NaN
constant: false
name: AKR1C4
type: Species
is: P17516
boundary condition: true

metaR AMPDA
is described by: ECO:0000269
name: Adenosine monophosphate deaminase
reactant: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.6
modifier: MODEL1310110047#

metaM 11 cis retfa e
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
has only substance units: false
name: fatty acid 11-cis-retinol
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57454
constant: false
boundary condition: false
is: HMDB00972

metaM HC01401 x
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
is: CHEBI:27668
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_84542e05_1763_4447_87d1_745ab5bb8f8f
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P07741
has only substance units: false
type: Species
is encoded by: hsa:353
name: APRT

http://identifiers.org/biomodels.db/MODEL1310110047#_c6249e06_8e78_4add_93d2_db9a96ce4acf
has only substance units: false
boundary condition: true
constant: false
name: ALDH5A1
initial amount: NaN
is: Q546H9
initial concentration: NaN
type: Species
is encoded by: hsa:7915
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_054d0794_3d40_406b_a3d8_2f38ca46cace
name: FUT8
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:2530
initial amount: NaN
is: Q546E0
is: SBO:0000252
has only substance units: false

metaR HACD9m
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000134
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reactant: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

http://identifiers.org/biomodels.db/MODEL1310110047#_e6da4115_6e9a_4680_94ba_fbbabe255527
is encoded by: hsa:2653
is: P23434
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: GCSH
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_6fce733b_fd1c_464c_948c_5893f585955c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1629
boundary condition: true
type: Species
is: P11182
constant: false
name: DBT
has only substance units: false
is: SBO:0000252

metaR RE0936E
type: Reaction
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
reactant: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: RE0936
is version of: http://identifiers.org/ec-code/3.4.17.23
fast: false

metaR EHGLAT2m
is described by: ECO:0000304
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
kinetic law: MODEL1310110047#
type: Reaction
reversible: false
modifier: MODEL1310110047#

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR r1603
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

metaR TCHOLAte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110047#
name: bile acid intracellular transport
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#

metaR AHCYStd
product: MODEL1310110047#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
fast: false
name: diffusion of S-Adenosyl-L-homocysteine

metaM cholate e
is: HMDB00619
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
constant: false
is: CHEBI:29747
boundary condition: false
name: Cholate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_7751a49f_78a6_48e0_b3f7_a9265ebfcefd
is: SBO:0000252
constant: false
is: Q02252
type: Species
boundary condition: true
is encoded by: hsa:4329
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ALDH6A1

http://identifiers.org/biomodels.db/MODEL1310110047#_b8f43204_ff72_4954_b455_77b4f0e298c3
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:8875
initial amount: NaN
initial concentration: NaN
is: A8K7W0
name: VNN2

metaR r1604
reversible: true
kinetic law: MODEL1310110047#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksi deg36 l
is: HMDB00143
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 36
type: Species
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:12936
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_b1b346fd_f090_44a5_845b_2cc6b9ea7137
initial concentration: NaN
initial amount: NaN
is: P48448
is: SBO:0000252
name: ALDH3B2
is encoded by: hsa:222
boundary condition: true
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3dcd8003_8eb7_48ee_b3e3_d0f8d0fb253a
is encoded by: hsa:11001
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: O14975
type: Species
initial amount: NaN
has only substance units: false
name: SLC27A2

http://identifiers.org/biomodels.db/MODEL1310110047#_56a4fafc_db88_452d_a0c0_ec399b0be3f8
is: Q7GXZ4
boundary condition: true
name: ND4L
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4539
initial amount: NaN
type: Species
has only substance units: false

metaM acetone c
type: Species
boundary condition: false
constant: false
is: HMDB01659
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: acetone
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: CHEBI:15347

metaM pan4p c
initial concentration: 1.0
is: CHEBI:47942
boundary condition: false
is: C01134
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
is: SBO:0000247
is: HMDB01416
type: Species
initial amount: NaN
constant: false

metaR N2M2NMASNtly
product: MODEL1310110047#
name: n2m2nmasn transport, extracellular to lysosome
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110047#
type: Reaction
fast: false
is described by: ECO:0000000

metaR DHORTS
type: Reaction
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
name: dihydroorotase
reactant: MODEL1310110047#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.3.2
is described by: ECO:0000269
product: MODEL1310110047#

metaM 3decdicoa m
name: 3,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_3a7c29d0_2975_441f_b1e9_d36d4a5a98a7
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:1757
is: A8K596
initial amount: NaN
name: SARDH
is: SBO:0000252

metaM doco13ecoa c
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
is: SBO:0000247
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false
boundary condition: false
name: 13-docosenoylcoa
type: Species

metaR NDPK1m
is: SBO:0000176
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110047#
fast: false
reversible: true
type: Reaction
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM Rtotal c
is: CHEBI:16189
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
constant: false
has only substance units: false
name: R total
boundary condition: false
type: Species
is: HMDB01448

metaR SPHS1Ptr
reversible: true
type: Reaction
is described by: ECO:0000000
name: sphingosine-1-phosphate transport
fast: false
product: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaM l2fn2m2masn g
boundary condition: false
constant: false
has only substance units: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN
type: Species
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247

metaR r1605
is described by: ECO:0000000
product: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_2a8e25bb_e3fc_49a9_8689_bd435da59775
initial amount: NaN
boundary condition: true
is encoded by: hsa:1503
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: P17812
name: CTPS1

metaR GALASE5ly
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
fast: false
name: beta-galactosidase, lysosomal
reactant: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:26174
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1

http://identifiers.org/biomodels.db/MODEL1310110047#_90a29352_c58a_4e90_a67c_2d0e0076dba8
name: DPM2
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:8818
initial amount: NaN
type: Species

metaM 3tetd7ecoa m
name: 3-hydroxy tetradecenoyl-7-coa
is: HMDB05066
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_de7e6941_0d1c_4799_b17d_d934d6210f44
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: TST
initial amount: NaN
is: Q16762
is encoded by: hsa:7263
boundary condition: true
has only substance units: false

metaR PYDXNK
name: pyridoxine kinase
type: Reaction
reactant: MODEL1310110047#
is described by: ECO:0000269
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.35
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
fast: false

metaM cholate c
constant: false
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Cholate
is: HMDB00619
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_810dd978_3dc0_4b73_9b9b_8867ca67f3de
initial concentration: NaN
type: Species
is encoded by: hsa:5211
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: PFKL
is: P17858

metaR r1606
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000

metaR NDPK1n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
is: SBO:0000176
product: MODEL1310110047#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
fast: false
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110047#

metaM acngalgbside hs g
name: sialyl galactosylgloboside
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16523
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
has only substance units: false
is: HMDB03406
constant: false

metaM pan4p e
is: CHEBI:47942
initial concentration: 1.0
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2
boundary condition: false
is: SBO:0000247
name: Pantetheine 4'-phosphate
is: HMDB01416
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR 3DSPHR
is version of: http://identifiers.org/ec-code/1.1.1.102
product: MODEL1310110047#
reversible: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
name: 3-Dehydrosphinganine reductase

metaM CE2705 n
boundary condition: false
has only substance units: false
is: HMDB02281
initial concentration: 1.0
type: Species
is: SBO:0000247
name: quinonoid dihydrobiopterin
is: CHEBI:15374
constant: false
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705

metaR GLCNACASE2ly
is described by: ECO:0000000
product: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110047#
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
is: SBO:0000176
type: Reaction

metaR LNLCCRNt
reactant: MODEL1310110047#
name: transport into the mitochondria (carnitine)
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
reversible: false
product: MODEL1310110047#
is described by: ECO:0000269

metaR AHCYSte
type: Reaction
fast: false
name: Transport of S-adenosyl-L-homocysteine
product: MODEL1310110047#
is described by: ECO:0000134
reactant: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_5cf056d3_adac_4757_84d9_1440e38196cd
is: Q9BZQ4
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:23057
is: SBO:0000252
name: NMNAT2
constant: false
has only substance units: false

metaR RAI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: retinal isomerase (11-cis)
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110047#

metaR GLCNACASE3ly
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110047#
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50

metaR FAOXC102C101m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_cea6c7c0_67b4_4224_a3e0_213f023b6965
constant: false
has only substance units: false
is encoded by: hsa:5336
type: Species
is: P16885
initial concentration: NaN
initial amount: NaN
name: PLCG2
boundary condition: true
is: SBO:0000252

metaM paf hs e
initial concentration: 1.0
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species
has only substance units: false
constant: false
is: CHEBI:36707
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR DHFR
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: dihydrofolate reductase
reversible: true
modifier: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
kinetic law: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_f5221b4c_7039_4d79_9974_4c93953c0b6e
is encoded by: hsa:766
initial concentration: NaN
type: Species
is: Q86YU0
constant: false
name: CA7
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaM asp L c
is: CHEBI:29991
type: Species
constant: false
initial amount: NaN
is: HMDB00191
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247
boundary condition: false
name: L-aspartate(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_38046268_9fa9_4a90_a6df_92c0d7dd4c32
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: GGH
is: Q92820
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8836

metaR BILIRUBtr
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110047#_a7f8aca2_b693_4f7f_8e2d_d5c376a25419
is: P13686
initial concentration: NaN
constant: false
type: Species
name: ACP5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_4110dae2_48fc_454c_9406_5afed955dc96
type: Species
is encoded by: hsa:641649
name: TMEM91
initial concentration: NaN
is: C9JZ62
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_30124979_b4c3_4c10_8c1c_daf5dfe24e99
is: SBO:0000252
initial amount: NaN
is: P47895
is encoded by: hsa:220
has only substance units: false
constant: false
initial concentration: NaN
name: ALDH1A3
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_1f2b672e_0048_4a57_90f0_eed0d41cf654
name: SLC2A4
is: SBO:0000252
is encoded by: hsa:6517
is: P14672
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR DOLPGT1 Uer
fast: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.267
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110047#

metaM prpp c
is: HMDB00280
constant: false
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial concentration: 1.0
is: CHEBI:58017
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00119

metaR ITCOAL1m
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.4

http://identifiers.org/biomodels.db/MODEL1310110047#_1307a8d8_918c_448e_864e_8b5243af76f6
is: SBO:0000252
constant: false
is encoded by: hsa:219
boundary condition: true
has only substance units: false
initial amount: NaN
is: P30837
initial concentration: NaN
type: Species
name: ALDH1B1

metaM HC00342 c
constant: false
is: CHEBI:16383
type: Species
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR RE0583C
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
type: Reaction
is described by: ECO:0000000
name: RE0583
is: SBO:0000176
reversible: true
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaR EX CE2915 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin exchange
type: Reaction

metaM clpnd c
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:53488
is: HMDB06528
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
name: clupanodonic acid

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
kinetic law: MODEL1310110047#
reversible: false

metaM hpdca e
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:32366
is: HMDB02259
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
name: margarate

metaM thcholoylcoa x
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: SBO:0000247
has only substance units: false
is: CHEBI:27403
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB12456
type: Species
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8bb5e0d4_e91e_4549_bdd6_ea910645cfbb
is encoded by: hsa:4535
initial concentration: NaN
name: ND1
is: Q85KV6
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaR FAOXC141C141OHm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ba1464b8_8270_407d_aba4_07232354e629
has only substance units: false
type: Species
is: Q8N142
boundary condition: true
is encoded by: hsa:122622
name: ADSSL1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_b6785af7_b531_44d0_8d84_c0edcac7fef8
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA177072
boundary condition: true
has only substance units: false
type: Species
name: _AA177072_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_8798a7dd_92ee_49d8_9193_f96917c8395c
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:114
is: Q4F7X0
is: SBO:0000252
name: ADCY8

metaM asp L e
is: CHEBI:29991
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
is: HMDB00191
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_b6f04da2_cc35_4d6e_9b27_cab03852a91e
boundary condition: true
has only substance units: false
is: Q92643
type: Species
initial amount: NaN
name: PIGK
initial concentration: NaN
constant: false
is encoded by: hsa:10026
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_366a26bc_2af4_41b1_a6ef_01f03d4a8f25
is: SBO:0000252
name: ACP1
is: B5MCC7
is encoded by: hsa:52
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR B3GNT11g
kinetic law: MODEL1310110047#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaR RE1796R
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: RE1796
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
type: Reaction
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110047#
reversible: true

metaM prpp e
is: HMDB00280
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
constant: false
has only substance units: false

metaR RE0691C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: RE0691
reactant: MODEL1310110047#
type: Reaction
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110047#

metaR MAN1PT2
type: Reaction
product: MODEL1310110047#
reversible: false
is: SBO:0000176
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.7.13
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
is described by: ECO:0000000
name: mannose-1-phosphate guanylyltransferase (GDP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c02380d8_51e0_4b3c_8d83_aaf7a011a6fd
type: Species
boundary condition: true
has only substance units: false
is: O00217
is encoded by: hsa:4728
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: NDUFS8

metaR RE3074X
is described by: ECO:0000000
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
name: RE3074
product: MODEL1310110047#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton

metaM clpnd e
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:53488
has only substance units: false
is: HMDB06528
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
name: clupanodonic acid

metaM hexdicoa r
is: C08260
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00672
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
name: hexadecanedioylcoa
initial amount: NaN

metaR ATPH2e
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
name: ATP diphosphohydrolase
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000269
reversible: false
is: SBO:0000176

metaM hpdca c
has only substance units: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: HMDB02259
type: Species
name: margarate
is: CHEBI:32366
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR ARACHDt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110047#
name: fatty acid transport via diffusion
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true

metaM dopasf c
type: Species
initial concentration: 1.0
initial amount: NaN
name: dopamine 3-O-sulfate
constant: false
is: SBO:0000247
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: CHEBI:37946
is: HMDB06275
has only substance units: false
boundary condition: false

metaR ECOAH12m
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_b8c2b40a_4bcb_4d29_8e14_6b92cad1db10
boundary condition: true
type: Species
is encoded by: hsa:5152
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110047#_3f92d7f7_d72a_404f_b708_365ad4f856b9
has only substance units: false
name: PKM2
constant: false
is: SBO:0000252
is encoded by: hsa:5315
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaM frdp c
is: CHEBI:175763
initial concentration: 1.0
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00961
is: C00448
is: SBO:0000247
constant: false
name: Farnesyl diphosphate

metaR FAOXC102C103x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_41c320f2_36ac_48aa_b6c6_e49dd52abd38
initial amount: NaN
is: P49189
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ALDH9A1
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:223

http://identifiers.org/biomodels.db/MODEL1310110047#_64f7e48d_706d_4516_b5f2_e9bb31abb66c
is: SBO:0000252
initial concentration: NaN
constant: false
is: P48735
type: Species
boundary condition: true
is encoded by: hsa:3418
name: IDH2
has only substance units: false
initial amount: NaN

metaR FAEL183
product: MODEL1310110047#
type: Reaction
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
name: fatty-acyl-CoA elongation (n-C18:3CoA)
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reversible: false
modifier: MODEL1310110047#

metaM idour l
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
constant: false
type: Species
name: L-iduronate

metaR C4CRNCPT2
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaR CYTK13n
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110047#
product: MODEL1310110047#
reversible: true
fast: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (dCMP,dATP),nuclear
is: SBO:0000176

metaM lnlncgcoa x
constant: false
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
is: HMDB06368
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57363
boundary condition: false
has only substance units: false

metaM xol7ah2 m
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
boundary condition: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
initial concentration: 1.0
constant: false

metaR NAt3 1
reactant: MODEL1310110047#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110047#
name: sodium proton antiporter (H:NA is 1:1)
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR

metaM dutp c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
has only substance units: false
is: HMDB01191
is: C00460
name: dUTP
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_6bc825f0_19b9_4f56_8793_f2ce16e0eec1
boundary condition: true
is encoded by: hsa:122481
type: Species
constant: false
initial amount: NaN
is: Q96M32
is: SBO:0000252
name: AK7
has only substance units: false
initial concentration: NaN

metaR OCD11COACPT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR TYMSULT
name: Tyramine Sulfotransferase
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110047#
reversible: false

metaM ksi deg4 l
constant: false
initial concentration: 1.0
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
type: Species
name: keratan sulfate I, degradation product 4
boundary condition: false
has only substance units: false
is: CHEBI:57737
initial amount: NaN
is: SBO:0000247
is: HMDB00868

metaR FUMSO3tm
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
is described by: ECO:0000269
reversible: true
product: MODEL1310110047#
name: Fumarate:sulfite antiport, mitochondrial
modifier: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8ca83e12_a6bc_4d87_b591_8cb54cb68cd6
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:10449
is: P42765
name: ACAA2
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_2bea59d3_ac49_4580_b813_e71bf66f85b0
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6392
has only substance units: false
is: O14521
name: SDHD

metaR B3GNT32g
type: Reaction
reactant: MODEL1310110047#
reversible: false
product: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110047#

metaM fuc L l
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
name: L-fucose
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:18287
initial amount: NaN
has only substance units: false

metaR UMPK6n
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110047#
fast: false
reversible: true
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110047#
name: UMP kinase (dCTP),nuclear

metaR RAI2
fast: false
is: SBO:0000176
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal isomerase (9-cis)
reversible: true
type: Reaction
product: MODEL1310110047#

metaR DNDPt31m
reversible: false
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110047#
name: dCDP transport via ATP antiport
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110047#_48399522_be3b_4ce3_844f_d2fbb5c0b5f3
is: SBO:0000252
initial concentration: NaN
is: O60312
boundary condition: true
type: Species
name: ATP10A
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:57194

metaR TCYNTt
is: SBO:0000185
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
fast: false
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is described by: ECO:0000000

metaR S6T4g
reactant: MODEL1310110047#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110047#_20f2f274_fd4f_410a_8a06_19a41ca51156
boundary condition: true
constant: false
is encoded by: hsa:956
is: SBO:0000252
type: Species
is: O75355
name: ENTPD3
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM 3dpdhb me m
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
is: CHEBI:50776
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaR ACCOAC
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_8f182f5e_9e66_40eb_a336_2d62d12b89f2
name: SLC25A6
is: Q6I9V5
is encoded by: hsa:293
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r0853
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110047#
reversible: false
product: MODEL1310110047#

metaR C181OHc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_2733cc5c_092f_4d01_acc2_fa0a1d531d89
boundary condition: true
has only substance units: false
constant: false
is: Q9P109
is encoded by: hsa:51301
is: SBO:0000252
initial amount: NaN
name: GCNT4
initial concentration: NaN
type: Species

metaM 3aib c
is: HMDB02166
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: (S)-3-aminoisobutyric acid
is: CHEBI:33094
is: SBO:0000247

metaR r2359
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110047#
is: SBO:0000185
reversible: true
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_9a1fd8aa_f1f0_48c5_8a7a_b800ef91547f
initial concentration: NaN
name: ALAS1
has only substance units: false
constant: false
is: P13196
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:211

metaR C50CPT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_8feeac02_8f5a_4b98_9de5_a517fa4a5e96
initial concentration: NaN
is: Q96E98
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:6005
name: RHAG
has only substance units: false

metaR DMNONCOACRNCPT1
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: DMNONCOACRNCPT1
reversible: true

metaR GGH 10FTHF7GLUe
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
type: Reaction

metaR PHEMEtm
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: Heme transport to cytosol
reversible: true
reactant: MODEL1310110047#
is: SBO:0000185
fast: false

metaR G14T21g
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
reactant: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110047#
type: Reaction
reversible: false

metaM ocdececrn c
type: Species
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: 11-octadecenoyl carnitine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_6d622f1c_3dad_487e_85e7_db849965b869
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: P09417
initial amount: NaN
has only substance units: false
is encoded by: hsa:5860
name: QDPR
boundary condition: true

metaR CERT1rt
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
name: ceramide transport protein
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

http://identifiers.org/biomodels.db/MODEL1310110047#_9768f801_5a84_415a_a5c0_502c65dee14b
is encoded by: hsa:1120
type: Species
has only substance units: false
initial amount: NaN
is: Q9Y259
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: CHKB

metaM dudp c
has only substance units: false
boundary condition: false
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
is: SBO:0000247
is: C01346
type: Species
is: HMDB01000
initial amount: NaN
constant: false
name: dUDP

metaR r2358
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_c729ef7c_0017_4ae9_b7ef_e6c0f34c9ac8
type: Species
is encoded by: hsa:2590
constant: false
name: GALNT2
is: Q10471
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r0629
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
reversible: true
modifier: MODEL1310110047#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reactant: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.22
is described by: ECO:0000000
product: MODEL1310110047#

metaR ARGSL
is: SBO:0000176
name: argininosuccinate lyase
modifier: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (435.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 4.3.2.1 Confidence Level: 4 AUTHORS: PMID:11747432,PMID:12408190,PMID:3463959 NOTES:
is version of: http://identifiers.org/ec-code/4.3.2.1

http://identifiers.org/biomodels.db/MODEL1310110047#_dadef403_6ba1_4c72_a2bb_1917e14189fc
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:1384
name: CRAT
boundary condition: true

metaR MHISOR
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: false
type: Reaction
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.21
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)

metaR r0560
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110047#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
reversible: false

metaR DOPABMO
type: Reaction
is: SBO:0000176
name: dopamine beta-monooxygenase
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/1.14.17.1
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000269

metaR G14T15g
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reversible: false
is: SBO:0000176

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is described by: ECO:0000000
reactant: MODEL1310110047#
product: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
is: SBO:0000176
fast: false
type: Reaction

metaR TETDEC2CRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM 3octdece1crn c
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 3-hydroxy-octadecenoyl carnitine
has only substance units: false
is: HMDB13336
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H47NO5 CHARGE: 0
type: Species

metaR RPEc
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reversible: true
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000134
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110047#
is: SBO:0000176

metaM idour c
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN
is: HMDB02704
name: L-iduronate
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:21338

metaR C102CPT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR r2357
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_913e3287_e023_4373_a81a_ab520ed60e5b
is: P15309
is encoded by: hsa:55
has only substance units: false
constant: false
name: ACPP
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_27c7b480_d5de_4d4b_a827_92c68b75a63f
has only substance units: false
is encoded by: hsa:123041
type: Species
name: SLC24A4
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q8NFF2
constant: false
initial concentration: NaN

metaR FAOXC164C143m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM h2o r
boundary condition: false
type: Species
initial concentration: 1.0
name: H2O
is: CHEBI:15377
initial amount: NaN
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
is: HMDB02111
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_87c2846e_959b_4e7a_bef3_7665beaddb63
name: ESD
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P10768
is encoded by: hsa:2098

metaM lnlncgcoa r
constant: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57363

metaR r0627
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is described by: ECO:0000000

metaR r0413
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
product: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:

metaR r2356
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true

metaM c101coa c
boundary condition: false
constant: false
has only substance units: false
is: C14143
name: decenoylcoa
is: HMDB04047
initial amount: NaN
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC102C101x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaM dopasf e
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate
is: HMDB06275
has only substance units: false
boundary condition: false
is: CHEBI:37946

metaR S6TASE3ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_cf109400_8ead_4335_ad10_70791c824a30
is: SBO:0000252
name: AICDA
is: Q546Y9
is encoded by: hsa:57379
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_29cd23fb_9f5f_4433_98bb_bf530468bb6d
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: P49753
is encoded by: hsa:10965
initial concentration: NaN
constant: false
name: ACOT2
boundary condition: true

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR SERGLNexR
fast: false
reversible: true
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM idour e
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
constant: false
name: L-iduronate
is: CHEBI:21338
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM 3octdece1crn e
notes: FORMULA: C25H47NO5 CHARGE: 0
constant: false
name: 3-hydroxy-octadecenoyl carnitine
is: SBO:0000247
is: HMDB13336
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR r2355
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_97651191_05f8_4e25_8cac_0c40efd744e8
name: GUSB
has only substance units: false
initial amount: NaN
is: P08236
is encoded by: hsa:2990
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_02aa930a_e085_4ad9_ab81_efe901562c40
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q549M5
is encoded by: hsa:4718
name: NDUFC2

http://identifiers.org/biomodels.db/MODEL1310110047#_27ec2d3a_3a99_418e_a30c_7d34dc8114c0
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: ST3GAL3
type: Species
is: SBO:0000252
is encoded by: hsa:6487

metaR AG13T6g
product: MODEL1310110047#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176

metaM gluside hs r
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:18368
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
name: D-glucosyl-N-acylsphingosine

metaR r2089
modifier: MODEL1310110047#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR SERt4
is: SBO:0000185
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: L-serine via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
reversible: false
fast: false
is described by: ECO:0000269
product: MODEL1310110047#

metaR r2354
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110047#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaM fuc L e
is: CHEBI:18287
is: HMDB00174
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: L-fucose
constant: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
is: HMDB00257
constant: false
is: CHEBI:16094
initial amount: NaN
type: Species
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR RE1527M
product: MODEL1310110047#
name: RE1527
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reversible: true
is: SBO:0000176

metaR NH4tn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: ammonia nuclear transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_26370fac_9ba6_48f2_905c_e8f2ec6f84e2
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6578
initial concentration: NaN
type: Species
name: SLCO2A1
is: Q92959
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_2d71226b_d0bf_4d62_b860_936e4151133b
initial amount: NaN
is: SBO:0000297
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species
is encoded by: hsa:51227
boundary condition: true
constant: false
initial concentration: NaN

metaR HEX10
is described by: ECO:0000212
type: Reaction
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
name: hexokinase (D-glucosamine:ATP)
fast: false
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
is: SBO:0000176
modifier: MODEL1310110047#
reactant: MODEL1310110047#

metaR r1602
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110047#
reversible: true
is described by: ECO:0000000

metaM h2o x
initial amount: NaN
is: C00001
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15377
is: HMDB02111
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
constant: false
name: H2O

http://identifiers.org/biomodels.db/MODEL1310110047#_fcae4703_39d8_4565_8d3b_db9f5d0d879b
is: O75610
name: LEFTY1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10637
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR r2353
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r1291
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_8fc11dac_f8ca_40bc_b123_8e054e174c1c
name: DPM3
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:54344
type: Species
is: Q86TM7
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_dc3f00eb_e840_43c7_a5c1_1ac4cac4cc7e
type: Species
name: ETFA:ETFB
is: SBO:0000297
has part: P13804
boundary condition: true
is encoded by: hsa:2108
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2109
has only substance units: false

metaR LEUt4
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-leucine transport in via sodium symport

metaM ksi deg33 l
name: keratan sulfate I, degradation product 33
boundary condition: false
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:12936
constant: false
initial amount: NaN

metaM hyptaur c
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: CHEBI:16668
name: Hypotaurine
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00965

metaM hs deg13 l
boundary condition: false
has only substance units: false
is: CHEBI:17180
initial amount: NaN
type: Species
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: HMDB01352
initial concentration: 1.0
is: SBO:0000247
constant: false
name: heparan sulfate, degradation product 13

metaM dadp n
name: dADP(3-)
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
is: CHEBI:57667
initial amount: NaN
constant: false
has only substance units: false

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR r0410
product: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaM c12dc c
is: SBO:0000247
initial amount: NaN
type: Species
name: dodecanedioyl carnitine
notes: FORMULA: C19H34NO6 CHARGE: -1
boundary condition: false
has only substance units: false
constant: false
is: HMDB00623
initial concentration: 1.0

metaR RADH3
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT
name: retinal dehydrogenase
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
is: SBO:0000176

metaM CE5868 e
has only substance units: false
type: Species
initial amount: NaN
name: N-acetyl-seryl-aspartate
is: SBO:0000247
is: CHEBI:27485
initial concentration: 1.0
constant: false
is: HMDB02710
boundary condition: false
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868

metaR r2352
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaM fuc L c
has only substance units: false
is: SBO:0000247
is: CHEBI:18287
is: HMDB00174
initial concentration: 1.0
initial amount: NaN
name: L-fucose
boundary condition: false
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_d931d169_5b17_4ba4_92c4_29382cd3a5b2
name: MPST
is: P25325
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:4357

metaR PPA
fast: false
name: inorganic diphosphatase
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
product: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110047#
reversible: false
is: SBO:0000176
type: Reaction

metaR ILEtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110047#
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000185
fast: false
name: L-isoleucine transport via diffusion (extracellular to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110047#_66a2622c_9a1e_4fd9_baf7_9dff6c6d7d00
has only substance units: false
name: HADHA
initial amount: NaN
initial concentration: NaN
is: E9KL44
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:3030

metaR r1292
is described by: ECO:0000000
product: MODEL1310110047#
name: Postulated transport reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
type: Reaction

metaR r1600
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
type: Reaction

metaR GLCAASE8ly
fast: false
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000269
reactant: MODEL1310110047#
name: beta-glucuronidase, lysosomal
reversible: false
is: SBO:0000176
modifier: MODEL1310110047#

metaM dadp m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
is: SBO:0000247
is: HMDB01508
name: dADP(3-)
boundary condition: false
is: CHEBI:57667
initial amount: NaN
constant: false

metaM C02528 r
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:36234
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: SBO:0000247
is: HMDB00518
has only substance units: false

metaR CYTK1m
is described by: ECO:0000134
fast: false
name: cytidylate kinase (CMP),mitochondrial
product: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
kinetic law: MODEL1310110047#
reversible: true
is: SBO:0000176

metaM 3aib m
constant: false
has only substance units: false
is: CHEBI:33094
is: HMDB02166
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-aminoisobutyric acid

metaR ARAB Lt
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
name: L-arabinoase extracellular transport
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_767931d1_c83b_4f7a_ad45_22bc02e3bbe0
constant: false
is encoded by: hsa:3988
type: Species
name: LIPA
initial amount: NaN
is: P38571
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_deb5a034_373b_41e4_878f_7444dcb6ad80
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55350
constant: false
has part: O95498
is encoded by: hsa:8875
initial amount: NaN
is: SBO:0000297
type: Species
boundary condition: true
name: VNN3:VNN2:VNN1

metaR r2097
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_8fd50368_d31b_438f_91ee_9be98e2abeb8
initial amount: NaN
is encoded by: hsa:4706
type: Species
initial concentration: NaN
name: NDUFAB1
has only substance units: false
is: O14561
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_364f4019_6b39_4f06_a4c2_f192149cc33f
has only substance units: false
is encoded by: hsa:127
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: P08319
name: ADH4
initial concentration: NaN
initial amount: NaN

metaM galside hs e
is: SBO:0000247
boundary condition: false
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
initial amount: NaN
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
type: Species
has only substance units: false

metaM tetpent6 e
has only substance units: false
boundary condition: false
is: HMDB06322
name: tetracosapentaenoic acid, n-6
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM h2o l
constant: false
is: HMDB02111
boundary condition: false
name: water
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
type: Species
has only substance units: false
is: SBO:0000247

metaR MANtly
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
product: MODEL1310110047#
name: mannose efflux from lysosome
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000

metaR r0633
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110047#
product: MODEL1310110047#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3

metaM urcan c
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:17771
has only substance units: false
constant: false
is: SBO:0000247
is: C00785
is: HMDB00301
name: Urocanate
boundary condition: false

metaM malttr e
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
initial amount: NaN
name: maltotriose
is: C01835
is: HMDB01262
boundary condition: false
is: CHEBI:27931
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

metaM lnlncgcoa m
name: gamma-linolenoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
is: HMDB06368
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
is: CHEBI:57363
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_e920cd4d_7b1e_4836_b1fa_97620a933683
boundary condition: true
is: O75355
name: ENTPD3
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:956

metaM thr L e
initial amount: NaN
boundary condition: false
name: L-threonine
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
constant: false
initial concentration: 1.0
is: CHEBI:16857
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_0147913c_14e7_4c59_bb11_5d2949386fb2
has only substance units: false
name: PKM2
type: Species
initial concentration: NaN
is: B4DNK4
constant: false
initial amount: NaN
is encoded by: hsa:5315
is: SBO:0000252
boundary condition: true

metaR r2098
reversible: true
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000185

metaR ARGSS
name: argininosuccinate synthase
is: SBO:0000176
kinetic law: MODEL1310110047#
fast: false
type: Reaction
reactant: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.3.4.5
notes: GENE_ASSOCIATION: (445.1) or (445.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_6836833f_78bb_4274_91c2_b42626da3ef3
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:23428
name: SLC7A8
initial concentration: NaN
has only substance units: false
is: Q9UHI5
constant: false

metaR CYTK1n
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_0bc1cb2a_1feb_4f17_8f03_cb6fe354bfc7
constant: false
is: A4D1D5
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5244
boundary condition: true
name: ABCB4
type: Species

metaM gmp g
type: Species
boundary condition: false
has only substance units: false
name: GMP(3-)
is: SBO:0000247
is: CHEBI:58115
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r0634
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.1
modifier: MODEL1310110047#
reversible: true
type: Reaction

metaR ADPCOACROT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR IMPC
reversible: true
name: IMP cyclohydrolase
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.1.2.3
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaR PRO1xm
type: Reaction
name: proline oxidase (NAD), mitochondrial
product: MODEL1310110047#
is described by: ECO:0000254
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.99.8
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
reversible: false
is: SBO:0000176

metaR RE1526M
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110047#
name: RE1526
fast: false
product: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
type: Reaction
reversible: true
is: SBO:0000176

metaR LTD4DP
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_825cd5ef_ea80_4ff8_bc4c_05ea96401b6f
is: Q92819
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3037
type: Species
name: HAS2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_a94b28e3_836c_4718_b654_5a6d7db4aef9
boundary condition: true
is encoded by: hsa:2744
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GLS
is: O94925

metaR r2099
reversible: true
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR BUTt2m
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
name: Butyrate mitochondrial transport via proton symport, reversible
product: MODEL1310110047#
modifier: MODEL1310110047#

metaM galside hs g
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
boundary condition: false
initial concentration: 1.0
constant: false
name: D-galactosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110047#_e12dec1f_57a2_4684_82b8_31a763c48fd4
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: PDE9A
type: Species
has only substance units: false
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110047#_ab3fc9c7_7d40_42f2_b203_9a199f0cfc02
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:954
name: ENTPD2
constant: false
is: Q5SPY7
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaM c10dc x
has only substance units: false
is: HMDB13325
name: sebacoyl carnitine
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C17H30NO6 CHARGE: -1
type: Species

metaR r1078
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Vesicular transport
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: false
type: Reaction

metaM cmpacna c
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57812
is: SBO:0000247
is: HMDB01176
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR NACASPtm
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
type: Reaction
reversible: false
product: MODEL1310110047#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_3473c8dc_e031_4308_a67e_fe9734a300e5
initial amount: NaN
constant: false
has only substance units: false
name: ACSL6
is: SBO:0000252
is: B2RB13
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:23305

metaM thr L c
is: SBO:0000247
name: L-threonine
has only substance units: false
initial amount: NaN
is: CHEBI:16857
constant: false
boundary condition: false
is: HMDB00167
type: Species
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179

metaM acgal g
is: HMDB00212
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0
is: CHEBI:28037
has only substance units: false
name: N-acetyl-D-galactosamine
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaR BHMT
reversible: false
notes: GENE_ASSOCIATION: (23743.1) or (635.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.5 Confidence Level: 4 AUTHORS: PMID:9281325 NOTES:
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.1.1.5
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is: SBO:0000176
name: betaine-homocysteine S-methyltransferase

metaM prostgh2 r
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
is: HMDB01381
has only substance units: false
is: CHEBI:57405
name: prostaglandin H2(1-)
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR GUAD
modifier: MODEL1310110047#
name: guanine deaminase
fast: false
notes: GENE_ASSOCIATION: (9615.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.3 Confidence Level: 4 AUTHORS: PMID:10075721 NOTES:
is described by: ECO:0000269
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.5.4.3

metaM hs deg8 l
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 8
has only substance units: false
is: SBO:0000247
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
initial amount: NaN
is: CHEBI:16126
constant: false
boundary condition: false

metaM pchol hs e
constant: false
type: Species
is: CHEBI:16110
name: Phosphatidylcholine
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM gmp e
is: SBO:0000247
name: GMP(3-)
is: CHEBI:58115
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
type: Species
is: HMDB01397
initial concentration: 1.0
initial amount: NaN

metaR PI4PP
product: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
is: SBO:0000176
name: phosphatidylinositol-4-phosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD

metaR LNELDCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
reversible: false
type: Reaction

metaR G6PDH2rer
reactant: MODEL1310110047#
is: SBO:0000176
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
product: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: true
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
fast: false
type: Reaction

metaM frdp r
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Farnesyl diphosphate
constant: false
is: HMDB00961
is: C00448

metaM 3deccrn c
is: SBO:0000247
boundary condition: false
name: 3-hydroxydecanoylcarnitine
initial amount: NaN
is: HMDB13325
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C17H33NO5 CHARGE: 0

metaR PHYCBOXL
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000176
name: L-Phenylalanine carboxy-lyase
modifier: MODEL1310110047#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB

metaR r0407
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_a4c9d0c9_8eed_4a39_90c1_0a0770e73aa7
constant: false
boundary condition: true
has only substance units: false
name: PPA1
is encoded by: hsa:5464
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q15181

metaR HOCTDECCRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaR r2093
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
type: Reaction
fast: false

metaM 3oddcoa x
name: 3-Oxododecanoyl-CoA
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
has only substance units: false
is: HMDB03937
initial amount: NaN
is: SBO:0000247
is: CHEBI:27868

metaR LNELDCCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
fast: false
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR DECCRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaM hexdicoa c
has only substance units: false
initial amount: NaN
name: hexadecanedioylcoa
is: HMDB02014
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

metaR AKR1D2
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.1.3
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c757518a_8166_43fe_9513_7ad2737ce2d5
is encoded by: hsa:3098
has only substance units: false
constant: false
boundary condition: true
is: B3KXY9
name: HK1
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r0630
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
kinetic law: MODEL1310110047#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.2
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is: SBO:0000176
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.3.1

metaR LALDO
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110047#
modifier: MODEL1310110047#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110047#

metaR r0783
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
modifier: MODEL1310110047#

metaM amet c
is: C00019
is: SBO:0000247
is: CHEBI:15414
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01185
has only substance units: false
name: S-Adenosyl-L-methionine
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false

metaM acgal1p c
initial amount: NaN
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
boundary condition: false
is: CHEBI:55404
has only substance units: false
constant: false
is: SBO:0000247
name: N-Acetyl-D-galactosamine 1-phosphate
initial concentration: 1.0
is: HMDB06480

http://identifiers.org/biomodels.db/MODEL1310110047#_cc204dce_62f7_4a00_976d_729f58b189e0
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:11253
name: MAN1B1
has only substance units: false
is: Q9UKM7

http://identifiers.org/biomodels.db/MODEL1310110047#_0dac5433_627c_4447_9b82_16fad55c9d8a
is encoded by: hsa:65010
name: SLC26A6
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9Y3Y1
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaM HC00250 e
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: hydrosulfide
initial amount: NaN
is: CHEBI:29919

metaR ABO9g
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
product: MODEL1310110047#
reversible: false
is: SBO:0000176
reactant: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
type: Reaction
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

metaR r0408
product: MODEL1310110047#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110047#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
type: Reaction

metaR CORE2GTg
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_9635e3f3_0c18_42fd_b3df_f0eb5a53ce92
name: AK3
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:50808
type: Species
is: E7ET30
initial concentration: NaN
is: SBO:0000252

metaM 2dp6mep m
has only substance units: false
type: Species
name: 2-Decaprenyl-6-methoxyphenol
initial amount: NaN
is: CHEBI:50774
constant: false
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r2094
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110047#

metaR SUBERCROT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_4f10d375_d6c9_49a1_bbf2_3141955ca17c
initial amount: NaN
name: SLC46A1
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:113235
type: Species
constant: false
initial concentration: NaN
is: Q96NT5

metaM pchol hs c
type: Species
is: SBO:0000247
is: CHEBI:16110
name: Phosphatidylcholine
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_2607499b_0cd9_48fb_a248_947c915472b5
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55967
is: F8VQS7
constant: false
initial concentration: NaN
name: NDUFA12

metaM 3dodtricoa m
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
is: HMDB11123
has only substance units: false
name: 3,6,9-dodecatrienoylcoa
is: SBO:0000247
type: Species
is: C05279
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_a4d2d9dc_cd3b_4849_8e1a_48fd4f938cd9
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:83715
name: ESPN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: B1AK53

metaM dcsptn1coa c
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
constant: false
initial amount: NaN
is: C16173
is: http://identifiers.org/pubchem.compound/47205483
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: HMDB06513
initial concentration: 1.0

metaM dudp m
name: dUDP(3-)
type: Species
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:60471
has only substance units: false

metaM HC00342 m
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: cis-aconitate(3-)
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383
initial amount: NaN
constant: false

metaR r0780
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110047#
reactant: MODEL1310110047#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:

metaM cholcoads x
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:27505
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
is: HMDB06889
has only substance units: false
constant: false
is: SBO:0000247

metaM lpam m
initial concentration: 1.0
type: Species
is: CHEBI:17460
is: HMDB00962
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
name: lipoamide
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.137
reversible: false
fast: false

metaM h2o n
is: HMDB02111
initial amount: NaN
name: water
type: Species
boundary condition: false
is: CHEBI:15377
constant: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
is: SBO:0000247

metaM uppg3 c
initial amount: NaN
is: SBO:0000247
is: CHEBI:57308
is: C01051
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
type: Species
is: HMDB01086
name: Uroporphyrinogen III
initial concentration: 1.0

metaR 3HBCDm
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity
type: Reaction
modifier: MODEL1310110047#
reversible: true
is described by: ECO:0000254
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial

metaM tetpent6 c
is: HMDB06322
is: SBO:0000247
initial amount: NaN
name: tetracosapentaenoic acid, n-6
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_48ee1cb8_7d9c_4399_95ff_e88fdb6ede83
is: A8K5J1
is: SBO:0000252
type: Species
initial concentration: NaN
name: UMPS
initial amount: NaN
is encoded by: hsa:7372
constant: false
boundary condition: true
has only substance units: false

metaR r2095
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110047#
product: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaM mmcoa S m
name: (S)-methylmalonyl-CoA(5-)
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
type: Species
is: HMDB02310
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57327

metaR G13MT U
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.132
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110047#_5b66a96b_98d9_423e_b263_d98c83c33770
is: SBO:0000252
name: ACP6
initial concentration: NaN
type: Species
boundary condition: true
is: Q9NPH0
has only substance units: false
is encoded by: hsa:51205
constant: false
initial amount: NaN

metaR ADA
kinetic law: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
name: Adenosine deaminase
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
product: MODEL1310110047#
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.4

metaM dudp n
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01000
has only substance units: false
boundary condition: false
name: dUDP(3-)
type: Species
initial concentration: 1.0
is: CHEBI:60471

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110047#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_493081f5_151e_44ef_b2c2_2fb07eafc0e4
is encoded by: hsa:6535
type: Species
initial amount: NaN
is: B4DIA3
name: SLC6A8
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR EX c51crn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_5a8c2706_5349_4930_84c8_51e3040197dc
type: Species
name: PIGS
is: Q8NBL9
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:94005

metaM h2o m
is: C00001
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:15377
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02111

metaM hdcea r
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: CHEBI:32372
initial amount: NaN
initial concentration: 1.0
is: HMDB03229
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: palmitoleate

metaM 3aib e
is: CHEBI:33094
initial amount: NaN
constant: false
is: HMDB02166
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
boundary condition: false

metaR DHCR71r
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
is: SBO:0000176
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_10703372_ed1e_45d7_9223_ddec7016f4a1
is: SBO:0000252
initial amount: NaN
is: O60331
name: PIP5K1C
is encoded by: hsa:23396
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_39efdfad_6df6_47c0_b820_bf101a849340
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5290
type: Species
boundary condition: true
is: P42336
constant: false
name: PIK3CA
initial concentration: NaN

metaM galside hs l
type: Species
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
is: CHEBI:12947
constant: false
boundary condition: false

metaR r2096
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_14cf7349_9b38_4f8f_b681_54fa85bdb2c5
initial concentration: NaN
name: HADH
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q16836
boundary condition: true
is encoded by: hsa:3033

metaR BCRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy butyryl carnitine into extra cellular space
type: Reaction

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_68dd6a48_6ebc_4a47_b1b9_4e1b3278dbd2
is: Q9BQL0
is encoded by: hsa:594
type: Species
name: BCKDHB
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEte
is described by: ECO:0000000
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110047#
is: SBO:0000185
reversible: true
name: blood group intracellular transport

metaR FACOAL170
reversible: true
fast: false
product: MODEL1310110047#
is: SBO:0000176
name: fatty-acid--CoA ligase
modifier: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR ACOX22x
kinetic law: MODEL1310110047#
reversible: false
product: MODEL1310110047#
name: acyl-Coenzyme A oxidase 2, branched chain
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
is version of: http://identifiers.org/ec-code/1.17.99.3
fast: false
is described by: ECO:0000304
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_096a4d10_b9c8_4d30_913b_48dd5aa365ff
is: Q9Y619
is encoded by: hsa:10166
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC25A15
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR NDPK10n
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110047#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM f6p c
has only substance units: false
is: CHEBI:57579
is: HMDB00124
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C00085
is: http://identifiers.org/pubchem.compound/3385
name: D-Fructose 6-phosphate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_af768155_9b6b_49c0_b5ae_474d91cc5122
has only substance units: false
is: A0PJM6
is encoded by: hsa:1120
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: CHKB
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_85de72a7_48ba_44b8_8225_522727bfb782
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5277
initial amount: NaN
type: Species
name: PIGA
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3f7312be_125d_4364_8ddb_cc68ce4e7f30
initial concentration: NaN
is: Q5SYN6
name: SLC22A3
initial amount: NaN
is encoded by: hsa:6581
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_d2f768c4_2ab1_4273_a3a9_d05a8adf56e4
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9UPR5
type: Species
boundary condition: true
has only substance units: false
name: SLC8A2
is encoded by: hsa:6543

metaR URIt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
name: uridine facilated transport in cytosol
reversible: true
fast: false
product: MODEL1310110047#
type: Reaction

metaM h2o c
name: H2O
constant: false
is: CHEBI:3303
is: C00001
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0
is: HMDB02111
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_994d11bc_e020_485b_93aa_f848c16d5a23
name: SLCO1B1
boundary condition: true
is encoded by: hsa:10599
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9Y6L6
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_bd9e7961_df00_419c_8a01_c9976a083d80
is: SBO:0000252
has only substance units: false
is: Q8TCD5
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: NT5C
boundary condition: true
is encoded by: hsa:30833

metaM hdca r
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
initial amount: NaN
is: C00249
name: Hexadecanoate (n-C16:0)
is: CHEBI:7896
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_a10d2213_4933_4734_82ff_f0c8076dc7c4
initial concentration: NaN
is encoded by: hsa:8560
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: DEGS1
constant: false
is: O15121
type: Species

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM ksii core2 pre8 g
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 8
is: C00130
is: HMDB00175
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2

metaM 5tedtricoa m
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: 5,8,11-tetradecatrienoylcoa
initial concentration: 1.0
constant: false
is: HMDB02288

metaM dadp c
type: Species
boundary condition: false
name: dADP
initial concentration: 1.0
is: SBO:0000247
is: C00206
is: HMDB01508
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaR r0787
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
fast: false
is described by: ECO:0000000
modifier: MODEL1310110047#
reactant: MODEL1310110047#

metaR CLPNDCOAtx
reversible: true
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000185
name: fatty acid intracellular transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110047#

metaM cs a l
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
type: Species
is: HMDB02183
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:36005
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
initial concentration: 1.0
constant: false

metaM HC01162 c
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: CHEBI:58376
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
type: Species

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR LEUTAm
is: SBO:0000176
fast: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.6.1.42
name: leucine transaminase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is described by: ECO:0000269
reversible: true

metaR r2091
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_a0720fec_bcb2_43b1_be44_0ed730ab9b79
type: Species
initial amount: NaN
name: COQ6
is: SBO:0000252
boundary condition: true
is: B7Z3K8
initial concentration: NaN
constant: false
is encoded by: hsa:51004
has only substance units: false

metaR HSD11B1r
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
kinetic law: MODEL1310110047#
name: 11-beta-hydroxysteroid dehydrogenase type 1
is described by: ECO:0000269
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.146

metaR LEUKTRE4t
type: Reaction
reversible: true
is described by: ECO:0000000
name: leukotriene E4 transport
is: SBO:0000185
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_d4ad58f1_61fc_41ca_b69f_9f18dda55fdf
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5973
name: RENBP
initial amount: NaN
initial concentration: NaN
is: P51606
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_7a825eff_1a16_43da_82ef_59ea17cd8f28
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: CROT
has only substance units: false
is encoded by: hsa:54677
is: SBO:0000252
is: E7EQF2

http://identifiers.org/biomodels.db/MODEL1310110047#_c75e3866_f926_4e40_b2bc_08329bdd0914
boundary condition: true
constant: false
is encoded by: hsa:65985
name: AACS
is: Q86V21
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_ee03a374_4142_44d3_8894_1d5892fb085b
has only substance units: false
is: P19623
name: SRM
is encoded by: hsa:6723
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaM ksi pre1 g
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 1
boundary condition: false
is: C00130
is: CHEBI:58053
constant: false
type: Species
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C79H129N5O57X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110047#_d8fd0fbe_bedb_47f9_a5e9_9e259ed48920
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3631
initial concentration: NaN
boundary condition: true
name: INPP4A
is: Q96PE3
constant: false
type: Species

metaM dutp n
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
name: dUTP
boundary condition: false
is: SBO:0000247
is: CHEBI:17625
constant: false
has only substance units: false
type: Species
is: HMDB01191

metaR r0784
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
reactant: MODEL1310110047#
fast: false
reversible: true
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
product: MODEL1310110047#

metaR HDECEACBP
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_69dc00b2_3d0a_4273_b9ac_834d5317afd2
initial amount: NaN
type: Species
name: NDUFB9
boundary condition: true
is: SBO:0000252
is: Q9Y6M9
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4715

metaM 3deccrn e
is: SBO:0000247
is: C02838
type: Species
has only substance units: false
is: HMDB00791
constant: false
initial amount: NaN
notes: FORMULA: C17H33NO5 CHARGE: 0
boundary condition: false
initial concentration: 1.0
name: 3-hydroxydecanoylcarnitine

metaR ACt2m
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
name: acetate mitochondrial transport via proton symport
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR r2090
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#

metaR ADPT
is version of: http://identifiers.org/ec-code/2.4.2.7
is: SBO:0000176
modifier: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
name: adenine phosphoribosyltransferase
type: Reaction
reactant: MODEL1310110047#
is described by: ECO:0000269

metaR PPDOx
kinetic law: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
type: Reaction
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
product: MODEL1310110047#
is described by: ECO:0000269
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEtg
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
reversible: true
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false

metaR TALA
modifier: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.2.1.2
name: transaldolase
is: SBO:0000176
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
reactant: MODEL1310110047#

metaR MTHFDm
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
type: Reaction
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000269

metaR r2092
is: SBO:0000185
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110047#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000000

metaR GLYBtm
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
reversible: true
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_49ee9f52_c509_4a1d_b719_da70c79ed8af
is: Q8TE54
is encoded by: hsa:115111
has only substance units: false
boundary condition: true
name: SLC26A7
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR THD1m
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
fast: false
reversible: true
modifier: MODEL1310110047#
name: NAD(P) transhydrogenase
is version of: http://identifiers.org/ec-code/1.6.1.2
product: MODEL1310110047#
reactant: MODEL1310110047#

metaR 5AOPtm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000134
name: 5-Aminolevulinate mitochondrial transport
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
is: SBO:0000185
reversible: true
fast: false
type: Reaction

metaM c12dc x
initial amount: NaN
is: C05279
is: HMDB11123
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C19H34NO6 CHARGE: -1
type: Species
name: dodecanedioyl carnitine
is: SBO:0000247

metaM saccrp L m
is: SBO:0000247
is: HMDB00279
constant: false
type: Species
is: CHEBI:57951
boundary condition: false
initial concentration: 1.0
name: L-saccharopinate(1-)
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
initial amount: NaN
has only substance units: false

metaM asp L m
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
is: SBO:0000247
name: L-aspartate(1-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:29991
type: Species
is: HMDB00191
constant: false
boundary condition: false

metaR RE3005M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3005
reversible: true
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#

metaR C2tcx
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_4183f0fc_339e_467f_8de8_869015c26064
has only substance units: false
is: O75387
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: SLC43A1
is encoded by: hsa:8501
initial amount: NaN

metaM dutp m
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
is: HMDB01191
boundary condition: false
is: CHEBI:17625
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

metaM lnlncgcoa c
is: CHEBI:57363
is: HMDB06368
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_4b83559d_c17a_49c0_bacd_c36ea7a44083
has only substance units: false
is: P43007
is encoded by: hsa:6509
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC1A4
type: Species
is: SBO:0000252
boundary condition: true

metaR GLNtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
is: SBO:0000185
kinetic law: MODEL1310110047#
name: L-glutamine transport via electroneutral transporter
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
reversible: false

metaM hdcea e
initial concentration: 1.0
constant: false
boundary condition: false
name: Hexadecenoate (n-C16:1)
type: Species
is: CHEBI:32372
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
initial amount: NaN
is: SBO:0000247

metaR GLNtN1
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Glutamine transport (Na, H coupled)
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_4e748870_c9f2_461e_8c1c_49e5cd1f88e9
constant: false
is: F6VPY9
boundary condition: true
name: SLC8A1
is encoded by: hsa:6546
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

metaM ametam c
constant: false
is: HMDB00988
is: SBO:0000247
is: C01137
name: S-Adenosylmethioninamine
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57443

metaM 3mldz c
type: Species
name: 1-methylimidazole-4-acetaldehyde
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
initial amount: NaN
has only substance units: false
constant: false
is: HMDB04181
is: CHEBI:28104

metaM 3hdeccoa m
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: 3-hydroxyhexadecenoylcoa
boundary condition: false
is: HMDB02288
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC2031836m
name: Beta oxidation of fatty acid
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110047#_bf2d76b0_740c_492a_8940_c213ce2ad8e4
boundary condition: true
is encoded by: hsa:52
is: Q59EH3
initial amount: NaN
has only substance units: false
constant: false
name: ACP1
type: Species
initial concentration: NaN
is: SBO:0000252

metaR DIDPtn
name: dIDP nuclear transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
is described by: ECO:0000000
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_1953be03_4dab_4301_933a_5335622eedfd
is encoded by: hsa:6713
name: SQLE
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is: Q5HYI4
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR CYSTGL
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.4.1.1
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES:NCD
reversible: false
name: cystathionine g-lyase
kinetic law: MODEL1310110047#

metaM m4masn g
boundary condition: false
initial concentration: 1.0
is: C05881
type: Species
initial amount: NaN
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
constant: false
is: SBO:0000247

metaR PPPGOm
fast: false
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
is: SBO:0000176
reversible: false
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.3.4
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: protoporphyrinogen oxidase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110047#_815f5d6f_32c5_45b1_82f3_32143c4d4c7f
is: Q92685
type: Species
has only substance units: false
is encoded by: hsa:10195
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: ALG3

metaM h2o g
initial concentration: 1.0
name: water
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15377
is: HMDB02111
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

http://identifiers.org/biomodels.db/MODEL1310110047#_d458f3f0_bd3d_40aa_b057_b19e4f27c5ae
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFA6
initial concentration: NaN
is: P56556
constant: false
is encoded by: hsa:4700
has only substance units: false

metaM gmp c
is: CHEBI:58115
name: GMP
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
boundary condition: false
is: C00144

metaR RIBt
reactant: MODEL1310110047#
reversible: true
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
name: ribose transport via diffusion
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_c48cd22b_9a23_495d_bce4_2c98e4b86a8d
name: ALG5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9Y673
constant: false
is encoded by: hsa:29880
type: Species

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR RE1796M
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
kinetic law: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
modifier: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_1277abb8_16f7_40e4_bff6_e71d75c98c5c
initial amount: NaN
name: COX8A
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1351
has only substance units: false
is: Q53XN1
boundary condition: true

metaR PPDOy
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110047#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is described by: ECO:0000269

metaR GTHOm
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
name: glutathione oxidoreductase
kinetic law: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176
is described by: ECO:0000254
reactant: MODEL1310110047#
type: Reaction

metaR ACt2r
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
fast: false
name: acetate reversible transport via proton symport
reversible: true
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_7cec47c2_c5eb_4c49_905f_c7147048751e
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: EHHADH
constant: false
is encoded by: hsa:1962
has only substance units: false
is: Q9NY65

metaR r0788
is: SBO:0000176
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaR ADPACTD
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaM galside hs c
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
has only substance units: false
is: CHEBI:12947

metaM xol7ah2 c
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
initial concentration: 1.0
constant: false

metaM gpi prot hs r
has only substance units: false
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
constant: false
is: C00249
is: SBO:0000247
boundary condition: false
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
initial amount: NaN
is: HMDB00220
is: CHEBI:7896
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_2f1f7f30_7c0b_4eb8_a6d6_c62366ec4670
is: P21399
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: ACO1
has only substance units: false
is encoded by: hsa:48

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaM malthx e
is: SBO:0000247
name: Maltohexaose
is: C01936
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
constant: false
type: Species
boundary condition: false

metaM 34hpl m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
is: CHEBI:36659
name: 3-(4-hydroxyphenyl)lactate
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB00755

http://identifiers.org/biomodels.db/MODEL1310110047#_3e0a44da_fdde_4467_8c94_0257c9d67b02
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:2687
is: P36269
has only substance units: false
boundary condition: true
initial concentration: NaN
name: GGT5

metaR r1701
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#

metaM h2o e
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
boundary condition: false
initial concentration: 1.0
is: C00001
name: H2O
is: CHEBI:15377
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB02111
has only substance units: false

metaM 2mb2coa c
constant: false
boundary condition: false
type: Species
name: 2-methylcrotonoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
is: HMDB02054
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_9c60371c_ea09_448b_b881_ccb722b38022
constant: false
is: SBO:0000252
name: PPA1
is: Q15181
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5464
boundary condition: true

metaR r0789
reactant: MODEL1310110047#
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaM 3oddcoa m
is: CHEBI:27868
has only substance units: false
is: SBO:0000247
name: 3-Oxododecanoyl-CoA
constant: false
initial amount: NaN
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
boundary condition: false
is: HMDB03937
initial concentration: 1.0

metaM C02528 c
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
is: HMDB00518
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:36234
constant: false
boundary condition: false
type: Species

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM gly x
is: SBO:0000247
is: CHEBI:15428
initial amount: NaN
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00123

metaM acgal c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28037
name: N-acetyl-D-galactosamine
type: Species
constant: false
boundary condition: false
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial amount: NaN
has only substance units: false

metaR FAOXC102C103m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR EX 3bcrn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy butyryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_a8c5f1d4_3439_4086_8255_3658d138525b
boundary condition: true
initial concentration: NaN
is: P33402
has only substance units: false
is: SBO:0000252
name: GUCY1A2
is encoded by: hsa:2977
constant: false
type: Species
initial amount: NaN

metaR AG13T18g
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#

metaR ATPH1e
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
name: ATP diphosphohydrolase
is: SBO:0000176
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
type: Reaction
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110047#
reactant: MODEL1310110047#

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_58ede8b4_08a2_466a_9cc4_5f31c9a2bfa7
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: CLYBL
initial amount: NaN
is: Q8N0X4
constant: false
has only substance units: false
is encoded by: hsa:171425

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_6e2fe76d_586c_4b7f_b771_e366ea2e6703
constant: false
boundary condition: true
is: Q9UBM1
is: SBO:0000252
type: Species
initial concentration: NaN
name: PEMT
has only substance units: false
is encoded by: hsa:10400
initial amount: NaN

metaR r0579
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
reversible: true
modifier: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.19
product: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_fd4dc139_a0f6_4785_a1d5_b3fff58a93f8
initial amount: NaN
is encoded by: hsa:2747
has only substance units: false
boundary condition: true
is: SBO:0000252
name: GLUD2
is: P49448
initial concentration: NaN
type: Species
constant: false

metaM ru5p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
boundary condition: false
is: CHEBI:58121
is: HMDB00618
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaM 34dhoxpeg c
name: 3,4-Dihydroxyphenylethyleneglycol
initial concentration: 1.0
is: C05576
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00318
has only substance units: false
is: http://identifiers.org/pubchem.compound/7902
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576

metaR SGPL12r
product: MODEL1310110047#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000304
type: Reaction
name: Sphingosine-1-phosphate lyase
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reactant: MODEL1310110047#
reversible: false

metaM 3dodtricoa x
has only substance units: false
initial amount: NaN
name: 3,6,9-dodecatrienoylcoa
constant: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C05279
is: HMDB11123
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c2efbb89_a410_40d2_8851_7154322b932e
is encoded by: hsa:LOC647190
name: _LOC647190_1_c
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM 3pg m
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00807
initial concentration: 1.0
is: CHEBI:58272
type: Species
is: SBO:0000247
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197

metaR CATp
is version of: http://identifiers.org/ec-code/1.11.1.6
type: Reaction
reversible: false
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:18634816,PMID:18634817 NOTES:NCD
name: catalase A, peroxisomal
product: MODEL1310110047#
is described by: ECO:0000134
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176

metaR CYTK12n
name: cytidylate kinase (dCMP,dCTP),nuclear
product: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000176
reversible: true

metaR 41R2A1H12BOOX
reversible: false
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is: SBO:0000176
modifier: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110047#
is described by: ECO:0000269

metaM docohepcoa m
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
type: Species
initial amount: NaN
boundary condition: false

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_1ed0bf3e_5872_40e5_b9d1_c5e72028c969
constant: false
name: CRAT
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1384
is: SBO:0000252

metaR HDCAtr
fast: false
is described by: ECO:0000000
product: MODEL1310110047#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_87d21651_3f66_4326_bbe6_f0d18c10d8da
is encoded by: hsa:204
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: AK2

http://identifiers.org/biomodels.db/MODEL1310110047#_e06a24c3_33c3_4519_99ab_d4c8e10542b1
is encoded by: hsa:116285
name: ACSM1
is: SBO:0000252
initial concentration: NaN
is: Q08AH1
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM pmtcoa r
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
constant: false
has only substance units: false
is: HMDB01338
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:3454

metaR r0578
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
product: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_110707cb_49ed_4ddc_9375_9b991c72ac24
initial concentration: NaN
has only substance units: false
name: DGKB
is encoded by: hsa:1607
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaR DHCR243r
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
reactant: MODEL1310110047#
is described by: ECO:0000134
kinetic law: MODEL1310110047#
name: 24-dehydrocholesterol reductase [Precursor]
reversible: false
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_aa985b8d_565b_4bfd_8fd6_1727f1e42f92
is encoded by: hsa:8399
initial concentration: NaN
has only substance units: false
type: Species
is: O15496
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PLA2G10

metaR DDPGAm
fast: false
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110047#

metaR LEUPHELAT2tc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR DMHPTCRNt
name: 2,6 dimethylheptanoyl crn transport
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_7e7dfe02_db55_4221_b74a_b27c10cca7be
initial amount: NaN
type: Species
name: SLC25A1
is: SBO:0000252
initial concentration: NaN
is: D9HTE9
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6576

metaR CERT2rt
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
reversible: true
type: Reaction
name: ceramide transport protein
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reactant: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_f46f0e0d_38bd_41d6_a568_077f0c7abcb2
name: PLCG1
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q9UFY1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5335

metaM eicostetcrn m
initial amount: NaN
is: CHEBI:57312
name: Eicosatetranoyl carnitine
constant: false
is: HMDB01356
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
initial concentration: 1.0
is: SBO:0000247

metaR 2AMACHYD
name: 2-Aminoacrylate hydrolysis
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#

metaM ksi deg2 l
has only substance units: false
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
name: keratan sulfate I, degradation product 2
is: CHEBI:30825
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00573
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_3913aac5_03c0_458a_b122_22b0e234fa82
is encoded by: hsa:4726
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NDUFS6
constant: false
is: Q6IBC4

metaR HISD
modifier: MODEL1310110047#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.1.3
reversible: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: histidase
reactant: MODEL1310110047#
is: SBO:0000176

metaR UMPK5n
product: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: UMP kinase (dATP),nuclear
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110047#

metaR GLYtp
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
is: SBO:0000185
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: true
fast: false
reactant: MODEL1310110047#
name: glycine passive transport to peroxisome
is described by: ECO:0000000

metaR 4MOPte
is: SBO:0000185
type: Reaction
fast: false
name: Transport of 4-methyl-2-oxopentanoate
product: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR ACNACNGALGBSIDEte
name: acnacngalgbside hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
is described by: ECO:0000000
reversible: true

metaM HC01434 x
name: oxalatosuccinate(3-)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:58931
boundary condition: false

metaR FUT99g
fast: false
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
reversible: false
is: SBO:0000176
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.152
name: Alpha-(1,3)-fucosyltransferase
reactant: MODEL1310110047#

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM dcsptn1coa m
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
is: C16173
is: HMDB06513
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110047#_3af7dae1_49c3_4642_944c_4ade28774c95
constant: false
initial amount: NaN
type: Species
name: PFAS
has only substance units: false
is encoded by: hsa:5198
is: SBO:0000252
is: Q6P4B4
boundary condition: true
initial concentration: NaN

metaR 13DAMPPOX
fast: false
is described by: ECO:0000212
is: SBO:0000176
reversible: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110047#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

metaR DHCRD2
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
type: Reaction
name: dihydroceramide desaturase
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110047#_5a1491e3_5407_4d17_b8e1_a69fa26c3b5b
name: HKDC1
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80201
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: B3KT70

metaR PE HSter
type: Reaction
reversible: true
name: phosphatidylethanolamine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaM prostgh2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
is: CHEBI:57405
initial amount: NaN
boundary condition: false
constant: false
type: Species
name: prostaglandin H2(1-)
has only substance units: false
is: HMDB01381
initial concentration: 1.0

metaM cs e l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02183
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
constant: false
boundary condition: false
is: CHEBI:36005
has only substance units: false
type: Species

metaM ppbng c
is: C00931
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
name: Porphobilinogen
has only substance units: false
type: Species
is: CHEBI:58126
is: HMDB00245
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:sulfate antiport, mitochondrial
product: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
is described by: ECO:0000269

metaR PRFGS
fast: false
name: phosphoribosylformylglycinamidine synthase
reversible: false
is: SBO:0000176
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.3.5.3
modifier: MODEL1310110047#
type: Reaction

metaR ENGASE3ly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110047#
reversible: false
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_4679ba75_46ae_4dbe_b2d9_2f49ac7a8082
is: Q6PXP3
initial amount: NaN
type: Species
name: SLC2A7
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:155184
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_1311c9bf_478c_4c72_8f4a_34ed7bdbe2b8
name: _T83654_1_e
type: Species
has only substance units: false
is encoded by: hsa:T83654
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaM dtmp e
is: CHEBI:26999
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: dTMP(2-)
is: HMDB01227
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

http://identifiers.org/biomodels.db/MODEL1310110047#_a3a7aea3_3f3a_42aa_80bf_7942f037496e
constant: false
name: LDHB
is: P07195
type: Species
is encoded by: hsa:3945
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM g1p e
is: SBO:0000247
is: HMDB01586
constant: false
type: Species
initial amount: NaN
name: alpha-D-glucose 1-phosphate(2-)
is: CHEBI:58601
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103

http://identifiers.org/biomodels.db/MODEL1310110047#_04d23702_e5f8_4dbe_ac32_75d116cf28bc
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4842
initial concentration: NaN
type: Species
is: B4DG68
boundary condition: true
initial amount: NaN
name: NOS1
constant: false

metaR AMACRp
is version of: http://identifiers.org/ec-code/5.1.99.4
is described by: ECO:0000269
reactant: MODEL1310110047#
name: alpha-methylacyl-CoA racemase
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (23600.2) or (23600.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid biosynthesis review uniprot NJ
fast: false

metaR r0842
is described by: ECO:0000000
modifier: MODEL1310110047#
name: Postulated transport reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction

metaM cmpacna n
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
is: HMDB01176
constant: false
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
type: Species

metaR EX 34hpp
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_b0fb8e1c_c5f3_4c66_aa14_a5d37116219f
boundary condition: true
initial concentration: NaN
constant: false
is: B7Z6M3
initial amount: NaN
is encoded by: hsa:8525
type: Species
is: SBO:0000252
has only substance units: false
name: DGKZ

metaR UREAt
product: MODEL1310110047#
name: Urea transport via facilitate diffusion
modifier: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
kinetic law: MODEL1310110047#
type: Reaction

metaM hs deg14 l
name: heparan sulfate, degradation product 14
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16126
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
initial amount: NaN

metaM omhpal r
initial concentration: 1.0
has only substance units: false
name: w-hydroxypalmiticacid
notes: FORMULA: C16H30O3 CHARGE: -1
is: HMDB06294
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_764b3776_0020_4f78_b166_d1f2634bf7cf
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA419122
initial amount: NaN
name: _AA419122_1_c
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR PTE3x
is: SBO:0000176
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
name: peroxisomal acyl-CoA thioesterase
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110047#
is described by: ECO:0000000

metaM pchol hs r
boundary condition: false
name: Phosphatidylcholine
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: CHEBI:16110

http://identifiers.org/biomodels.db/MODEL1310110047#_50b29eaf_a6bc_4ee0_b17d_ed9eb6e39342
boundary condition: true
has only substance units: false
constant: false
is: O95263
type: Species
is encoded by: hsa:8622
initial amount: NaN
is: SBO:0000252
name: PDE8B
initial concentration: NaN

metaM stcoa x
initial concentration: 1.0
initial amount: NaN
is: HMDB01114
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: C00412
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
type: Species
is: CHEBI:57394
name: Stearoyl-CoA (n-C18:0CoA)

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR r0841
modifier: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
fast: false
name: Free diffusion
reactant: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.271

metaR CSNATer
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
fast: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.7
is described by: ECO:0000254
is: SBO:0000176
reactant: MODEL1310110047#
name: carnitine O-acetyltransferase, endolasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm

metaR G14T14g
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reactant: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_90ad6b38_9b6b_49c7_b409_c0d685b19fc2
boundary condition: true
has part: Q86TM7
is: SBO:0000297
has part: O94777
is encoded by: hsa:54344
name: DPM3:DPM1:DPM2
constant: false
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN
is encoded by: hsa:8813
has part: O60762
type: Species
has only substance units: false

metaM HC02187 c
name: reverse-triiodthyronine
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:28774
type: Species

metaR FACOAL184
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110047#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true
name: fatty-acid--CoA ligase

metaM ditp n
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
is: SBO:0000247
constant: false
is: HMDB03537
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR q10tm
type: Reaction
reactant: MODEL1310110047#
reversible: true
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110047#
fast: false
name: transport of ubiquinone into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110047#

metaM dcmp n
has only substance units: false
name: dCMP(2-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
constant: false
type: Species
initial amount: NaN
is: CHEBI:57566

metaM 5tedtricoa x
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial amount: NaN
name: 5,8,11-tetradecatrienoylcoa

metaR NACHEX26ly
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110047#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176

metaR DM dgpi prot hs r
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaR ACNACNGALGBSIDEtg
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
name: acnacngalgbside hs intracellular transport
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
product: MODEL1310110047#

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM prostgh2 c
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
is: HMDB01381
boundary condition: false
is: CHEBI:57405
initial concentration: 1.0
is: SBO:0000247

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaR GUAt
name: Guanine transport
is described by: ECO:0000269
reactant: MODEL1310110047#
product: MODEL1310110047#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000185
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_1c784211_607d_4629_94c7_5bbabbc2c3c8
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:2878
has only substance units: false
is: SBO:0000252
name: GPX3
constant: false
boundary condition: true
is: P22352

http://identifiers.org/biomodels.db/MODEL1310110047#_8e5a55a5_7271_4637_9e50_b2e17680c8e2
boundary condition: true
name: IVD
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3712
is: B3KVI7

metaM hdcea c
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
boundary condition: false
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial amount: NaN
constant: false
is: HMDB03229
is: CHEBI:32372
has only substance units: false
initial concentration: 1.0

metaR GLYtm
name: glycine passive transport to mitochondria
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110047#
type: Reaction
is: SBO:0000185

metaR URATEt
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
type: Reaction
name: urate export from cytosol
product: MODEL1310110047#
is described by: ECO:0000000

metaR r0202
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
is described by: ECO:0000000
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110047#
type: Reaction

metaM dtmp c
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP
boundary condition: false
is: C00364
type: Species
constant: false
is: CHEBI:26999
initial amount: NaN
has only substance units: false
is: HMDB01227
initial concentration: 1.0

metaM tag hs e
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
boundary condition: false
is: CHEBI:17855
name: triglyceride
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_7ce3bb30_f57f_406d_8f86_2d4aee2fc163
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: PPAP2C
initial concentration: NaN
is: E9PAY8
boundary condition: true
is encoded by: hsa:8612
type: Species
constant: false

metaM g1p c
is: C00103
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01586
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial amount: NaN
is: CHEBI:58601
boundary condition: false
initial concentration: 1.0
name: D-Glucose 1-phosphate

metaR PRAGSr
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylglycinamide synthase
is: SBO:0000176
reversible: true
type: Reaction
fast: false
product: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.2
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#

metaR C204CPT2
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
fast: false
modifier: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
name: arachidonic acid transport into the mitochondria
type: Reaction
reactant: MODEL1310110047#
reversible: false

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ed9f8cf7_eba7_473b_9888_59cb4fa3b921
is: Q6IB80
boundary condition: true
is encoded by: hsa:4709
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: NDUFB3
initial amount: NaN
type: Species

metaR GLCNACASE4ly
kinetic law: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
product: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
fast: false

metaM tag hs c
name: triglyceride
is: SBO:0000247
constant: false
is: CHEBI:17855
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR S6T5g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
reversible: false
product: MODEL1310110047#
type: Reaction

metaR CATm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.11.1.6
reactant: MODEL1310110047#
type: Reaction
name: catalase
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES:TV
modifier: MODEL1310110047#
product: MODEL1310110047#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8df371b5_8129_4784_a8d4_2ac5e2937e33
name: GSTZ1
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2954
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_9518855e_92e1_4280_87f6_b81cd914d409
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8789
has only substance units: false
is: SBO:0000252
is: O00757
name: FBP2

metaM dcsptn1coa x
is: HMDB06513
constant: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: C16173
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r0426
modifier: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.34
is: SBO:0000176
kinetic law: MODEL1310110047#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
product: MODEL1310110047#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaR OCDCEAtr
name: fatty acid transport via diffusion
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaR FACOAL245 1
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110047#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110047#
name: fatty-acid--CoA ligase
reactant: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR PDE1
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.4.17
is described by: ECO:0000269
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.4.35
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is: SBO:0000176
reversible: false

metaR r0999
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110047#
name: Facilitated diffusion
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_6c9ddbf5_911f_459c_a706_e58b460f979a
initial concentration: NaN
is encoded by: hsa:1809
type: Species
boundary condition: true
name: DPYSL3
is: Q8IXW6
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR CYTD
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
fast: false
reactant: MODEL1310110047#
name: cytidine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.5
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000176
product: MODEL1310110047#
type: Reaction

metaR PIt9
is: SBO:0000185
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
is described by: ECO:0000006
reversible: true
name: phosphate transport in/out via two Na+ symporter
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (142680.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889 NOTES:MM

metaR TSULt4 3
is: SBO:0000185
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000269
reversible: true
name: thiosulfate transport via sodium symport
fast: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
modifier: MODEL1310110047#

metaM pchol hs m
is: CHEBI:16110
has only substance units: false
name: Phosphatidylcholine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
constant: false
type: Species
is: SBO:0000247

metaR r0571
type: Reaction
reversible: true
product: MODEL1310110047#
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
is version of: http://identifiers.org/ec-code/1.5.1.8
fast: false
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR LCAT1e
notes: GENE_ASSOCIATION: (3931.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.43 Confidence Level: 4 AUTHORS: PMID:11435418,PMID:11966470 NOTES:NJ
product: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.43
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
name: Lecithin-cholesterol acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110047#_0a9aac68_b8af_4bc2_ad6d_e9e3dec609d8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P28331
type: Species
boundary condition: true
is encoded by: hsa:4719
has only substance units: false
name: NDUFS1
constant: false

metaR r2344
product: MODEL1310110047#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r0639
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
fast: false
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
is: SBO:0000176

metaR PTDCACRNCPT2
product: MODEL1310110047#
name: pentadecanoate transport into the mitochondria
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_efe3a6f2_09bf_4624_8830_7749d6f8928d
has only substance units: false
initial concentration: NaN
boundary condition: true
name: GALNT8
is: Q9NY28
is encoded by: hsa:26290
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR INSt
product: MODEL1310110047#
name: Inosine transport (diffusion)
type: Reaction
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is described by: ECO:0000269
reversible: true

metaM ksi deg16 l
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:16953
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 16
is: SBO:0000247
is: HMDB00812
constant: false

metaR GLCURtly
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
modifier: MODEL1310110047#
reactant: MODEL1310110047#
name: glucuronate transport into lysososme
reversible: true
product: MODEL1310110047#

metaR 10FTHFtm
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
reactant: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false

metaR MM7B2g
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false

metaM prostgd2 r
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
is: HMDB01403
boundary condition: false
initial concentration: 1.0
is: CHEBI:57406
name: prostaglandin D2(1-)
is: SBO:0000247
has only substance units: false
constant: false

metaR r0998
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110047#
name: Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
type: Reaction

metaR C161CPT12
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
is: SBO:0000176
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
fast: false

metaR PIt8
name: phosphate transport in/out via Na+ symporter
fast: false
is: SBO:0000185
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is described by: ECO:0000006
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

metaR DOLPMT1 Uer
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is described by: ECO:0000000
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.258

http://identifiers.org/biomodels.db/MODEL1310110047#_eeeb2d85_43ce_474f_a0d0_68babc160ec3
boundary condition: true
name: FUT8
initial amount: NaN
is encoded by: hsa:2530
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q9BYC5

metaR RE3568C
is: SBO:0000176
name: RE3568
type: Reaction
fast: false
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110047#

metaR r0570
fast: false
modifier: MODEL1310110047#
type: Reaction
reversible: true
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is described by: ECO:0000000
product: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.3.2

metaR FAOXC226m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR ODECOAtx
name: fatty acid intracellular transport
fast: false
reversible: true
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000

metaR DRBK
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110047#
name: Deoxyribokinase
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.15

http://identifiers.org/biomodels.db/MODEL1310110047#_9d629ad6_05d8_422f_952f_199854370468
is encoded by: hsa:292
initial concentration: NaN
has only substance units: false
name: SLC25A5
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: Q6NVC0

http://identifiers.org/biomodels.db/MODEL1310110047#_92b54096_037f_4d4b_a9f4_db872f95c388
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3036
name: HAS1
constant: false
initial amount: NaN
is: SBO:0000252
is: Q8IYH3
boundary condition: true

metaM HC01434 m
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
type: Species
name: oxalatosuccinate(3-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR DHCR72r
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.21
is described by: ECO:0000269
reactant: MODEL1310110047#
is: SBO:0000176
name: 7-dehydrocholesterol reductase
fast: false
product: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
modifier: MODEL1310110047#

metaR r2347
fast: false
reactant: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110047#_7bb99ffa_d967_45ea_9f59_eb8fe0af39f5
is: Q5MY95
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: ENTPD8
constant: false
initial concentration: NaN
is encoded by: hsa:377841
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_1f3775e8_2002_40ee_b2f7_ff13413ee86b
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: PLCXD2
initial amount: NaN
is encoded by: hsa:257068
is: Q0VAA5
type: Species
has only substance units: false

metaR PROSTGF2t
kinetic law: MODEL1310110047#
type: Reaction
reversible: true
modifier: MODEL1310110047#
is: SBO:0000185
fast: false
reactant: MODEL1310110047#
name: prostaglandin uniport
product: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110047#_3b207694_4d19_4756_b502_85cbc0fcd305
is encoded by: hsa:2628
initial concentration: NaN
name: GATM
has only substance units: false
is: P50440
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_d45238ae_1df6_4dd5_969b_ff841b039d5b
constant: false
has only substance units: false
is: B3KXN9
name: ADO
is encoded by: hsa:84890
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR S6TASE13ly
fast: false
is: SBO:0000176
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: true

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR C8CRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaM 3hexdcrn c
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C23H45NO5 CHARGE: 0
has only substance units: false
name: 3-hydroxyhexadecanoylcarnitine
is: HMDB13336

metaR KSII CORE4t
is: SBO:0000185
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core4) transport, golgi to extracellular
product: MODEL1310110047#
type: Reaction

metaR r2346
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_afc0f0b7_f350_49be_a6af_8d32e33de7ae
constant: false
initial concentration: NaN
is encoded by: hsa:2982
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: D6RDW3
name: GUCY1A3

metaR FACOAL245 2
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
reactant: MODEL1310110047#
fast: false
type: Reaction
modifier: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110047#_5d75c261_0ca0_4239_9e73_06e784ff7565
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6483
boundary condition: true
is: Q16842
is: SBO:0000252
type: Species
has only substance units: false
name: ST3GAL2
constant: false

metaM HC02187 e
name: reverse-triiodthyronine
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
is: CHEBI:28774
is: SBO:0000247

metaM CE2917 e
name: apelin-13
notes: FORMULA: C69H114N23O16S CHARGE: 3 INCHI: InChI=1/C69H111N23O16S/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79)/p+3/t42-,43-,44-,45+,46-,47+,48+,49+,50-,51+,52+,53-/m1/s1 EHMN_ABBREVIATION: CE2917
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C01936
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
constant: false

metaM acgal l
initial concentration: 1.0
constant: false
name: N-acetyl-D-galactosamine
initial amount: NaN
is: SBO:0000247
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:28037

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR B3GNT33g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is: SBO:0000176
reversible: false
product: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#

metaR PI5P3K
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.137
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reactant: MODEL1310110047#
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.1.153

metaM eicostetcrn c
type: Species
initial concentration: 1.0
name: Eicosatetranoyl carnitine
initial amount: NaN
boundary condition: false
is: CHEBI:57312
constant: false
is: HMDB01356
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
has only substance units: false

metaR ACONT
name: aconitase
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110047#
product: MODEL1310110047#

metaM xol7ah2al m
type: Species
initial concentration: 1.0
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
boundary condition: false
is: HMDB06894
constant: false
is: CHEBI:27428
has only substance units: false
is: SBO:0000247

metaM pmtcoa m
boundary condition: false
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:57379
is: C00154

metaR KSII CORE2t
name: keratan sulfate II (core2) transport, golgi to extracellular
reversible: false
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaM dtmp m
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:26999
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: dTMP
is: C00364
is: HMDB01227

metaR r2341
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185

metaM ddece1crn e
name: dodecenoyl carnitine
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00791
is: SBO:0000247
notes: FORMULA: C19H35NO4 CHARGE: 0
is: C02838
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_1e8e5452_576e_4af9_837c_38aa73a662e8
type: Species
initial concentration: NaN
is encoded by: hsa:5287
has only substance units: false
boundary condition: true
is: O00750
name: PIK3C2B
constant: false
is: SBO:0000252
initial amount: NaN

metaM man c
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
initial concentration: 1.0
has only substance units: false
is: C00159
boundary condition: false
is: HMDB00169
type: Species
name: D-Mannose

metaR DASCBR
reversible: false
is version of: http://identifiers.org/ec-code/1.8.4.1
type: Reaction
fast: false
product: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
name: dehydroascorbate reductase
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_73bbca2f_ef2c_4daf_a2c4_df02a472f3e7
is encoded by: hsa:47
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: P53396
name: ACLY
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_066e284f_8aec_40cd_97ee_56ca704ea574
constant: false
is: Q16719
type: Species
initial amount: NaN
boundary condition: true
name: KYNU
is encoded by: hsa:8942
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM 3hexdcrn e
is: HMDB13336
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C23H45NO5 CHARGE: 0
has only substance units: false
name: 3-hydroxyhexadecanoylcarnitine

metaR r0575
product: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.48
fast: false
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#

metaR H2CO3D
reversible: true
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
name: carboxylic acid dissociation
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.1
is: SBO:0000176

metaR r0422
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_b3d1f89e_64b6_468c_a5ce_c72136e2aea9
is encoded by: hsa:56954
initial concentration: NaN
name: NIT2
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q9NQR4

metaR ICDHxm
reactant: MODEL1310110047#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.41
product: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
name: Isocitrate dehydrogenase (NAD+)
fast: false
kinetic law: MODEL1310110047#

metaR AG13T5g
is described by: ECO:0000000
fast: false
product: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110047#

metaR r0208
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/4.4.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#

metaM mal L e
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00156
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: CHEBI:15589
constant: false
name: (S)-malate(2-)

metaR NCKt
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
name: Na+/Ca2+-K+ exchange
reactant: MODEL1310110047#

metaR G14T20g
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110047#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is: SBO:0000176
modifier: MODEL1310110047#

metaR r1090
is described by: ECO:0000000
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110047#
fast: false
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110047#
product: MODEL1310110047#

metaR DADAe
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reactant: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
name: Deoxyadenosine deaminase, extracellular
type: Reaction

metaR EX tetdec2crn
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_b3a609a2_499e_4648_b756_9e96ce4f144d
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:2348
name: FOLR1

metaM cmpacna g
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
initial concentration: 1.0
is: HMDB01176
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
constant: false
is: CHEBI:57812

metaR r2079
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
name: Type IIIA glycolipid
is: CHEBI:15347
type: Species
initial concentration: 1.0
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01659
is: SBO:0000247
has only substance units: false

metaR PDE4
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.4.35
type: Reaction
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: MODEL1310110047#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.17
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_291eaa27_9be9_4c59_b445_489f3b109911
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: CMAS
is: Q8NFW8
has only substance units: false
is encoded by: hsa:55907
boundary condition: true

metaR N3Tg
is: SBO:0000176
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
reversible: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.122
reactant: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_20801705_a315_4773_95f5_c2882cf6953e
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3074
name: HEXB
type: Species
constant: false
has only substance units: false
is: P07686
initial concentration: NaN

metaM frdp x
type: Species
initial concentration: 1.0
name: farnesyl pyrophosphate(3-)
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:175763

metaR TAUBETAtc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaM s2l2n2m2masn e
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: de-Fuc form of PA6
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: HMDB00244
is: CHEBI:3554
is: C00255
initial concentration: 1.0
initial amount: NaN
type: Species

metaM digalside hs c
is: C06126
boundary condition: false
name: Digalactosylceramide
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
constant: false
is: http://identifiers.org/pubchem.compound/8383
is: SBO:0000247

metaM 3hdcoa c
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB13325
name: (S)-3-Hydroxydecanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4

metaM ksii core4 pre4 g
is: CHEBI:58053
is: C00130
name: keratan sulfate II biosynthesis, precursor 4
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00175
boundary condition: false
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1

metaM dttp n
is: CHEBI:37568
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
has only substance units: false
is: HMDB01342
is: SBO:0000247
constant: false
boundary condition: false
is: C00459
name: dTTP
type: Species

metaR HIVCACBP
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaM glu5sa m
is: C01165
type: Species
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02104
is: CHEBI:17232
name: L-Glutamate 5-semialdehyde
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_9e75aa35_d112_4655_b49b_da499aa4b54b
has only substance units: false
initial amount: NaN
is encoded by: hsa:1610
constant: false
initial concentration: NaN
boundary condition: true
name: DAO
type: Species
is: SBO:0000252
is: P14920

metaM ddece1crn c
name: dodecenoyl carnitine
is: HMDB03712
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C19H35NO4 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false

metaM 34dhoxpeg e
is: HMDB00318
type: Species
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
name: 3,4-Dihydroxyphenylethyleneglycol
constant: false
is: http://identifiers.org/pubchem.compound/7902
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C05576
boundary condition: false

metaR r0424
is version of: http://identifiers.org/ec-code/1.17.1.4
is described by: ECO:0000000
modifier: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reversible: true
type: Reaction
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
reactant: MODEL1310110047#

metaR r0638
is version of: http://identifiers.org/ec-code/2.8.1.2
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction

metaR LEUKTRF4t
name: leukotriene F4 transport
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#

metaR PTDCACRNCPT1
product: MODEL1310110047#
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine fatty-acyl transferase

http://identifiers.org/biomodels.db/MODEL1310110047#_6e199d82_40d3_4e90_897c_4627ab1b395a
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: NEU1
boundary condition: true
initial amount: NaN
is encoded by: hsa:4758
is: Q99519
initial concentration: NaN

metaM mal L c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
name: (S)-malate(2-)
is: HMDB00156
is: CHEBI:15589
constant: false

metaM btcoa m
initial concentration: 1.0
is: CHEBI:57371
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: C00136
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
name: Butanoyl-CoA
is: HMDB01088

http://identifiers.org/biomodels.db/MODEL1310110047#_b1b60191_3fa4_4f35_9d38_e498293d9708
constant: false
initial concentration: NaN
is: SBO:0000252
is: P49753
name: ACOT2
is encoded by: hsa:10965
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaM pe hs r
is: SBO:0000247
is: CHEBI:16038
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
initial concentration: 1.0

metaR PIt7
reactant: MODEL1310110047#
is: SBO:0000185
name: phosphate transport in/out via three Na+ symporter
modifier: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
product: MODEL1310110047#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110047#

metaR ACNAMlt
modifier: MODEL1310110047#
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
name: N-acetylneuraminate transport into lysososme

http://identifiers.org/biomodels.db/MODEL1310110047#_4dc12cc5_e85a_4bb5_b271_7589ce5ee494
boundary condition: true
has only substance units: false
is encoded by: hsa:445
initial concentration: NaN
is: P00966
name: ASS1
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaM dha e
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB01882
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
constant: false
has only substance units: false
initial concentration: 1.0
name: glycerone
is: CHEBI:16016
initial amount: NaN

metaR SIAT9g
modifier: MODEL1310110047#
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.9
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
product: MODEL1310110047#
is: SBO:0000176

metaM CE5788 e
boundary condition: false
is: CHEBI:27485
is: SBO:0000247
type: Species
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
is: HMDB02710
name: kinetensin 1-7
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaM fald m
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde
is: SBO:0000247
is: HMDB01426
constant: false
initial amount: NaN
is: CHEBI:16842

metaM gpi hs r
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
initial concentration: 1.0
constant: false
is: CHEBI:16240
is: SBO:0000247
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110047#_7ea6f340_8ba4_4adc_aafc_e1f7480bbfbf
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: PDE9A
is encoded by: hsa:5152
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
is: CHEBI:15347
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: Type IIIA glycolipid
is: HMDB01659
is: SBO:0000247

metaM dnad c
constant: false
is: CHEBI:18304
is: SBO:0000247
is: C00857
is: HMDB01179
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
boundary condition: false
name: Deamino-NAD+
initial amount: NaN

metaR r0423
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
modifier: MODEL1310110047#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
kinetic law: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_8eb832db_7d7a_4deb_8ba8_a02c16186c28
constant: false
initial concentration: NaN
name: _AI480132_1_c
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI480132
is: SBO:0000252
type: Species

metaM 20ahchsterol m
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
constant: false
name: 20-hydroxycholesterol
is: CHEBI:1296
boundary condition: false
is: HMDB06283
is: SBO:0000247
has only substance units: false

metaM thym e
initial concentration: 1.0
is: CHEBI:17821
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: SBO:0000247
type: Species
is: HMDB00262
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
name: thymine

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM CE5867 e
initial concentration: 1.0
name: N-acetyl-seryl-aspartyl-lysyl-proline
is: HMDB02710
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
constant: false
is: CHEBI:27485
boundary condition: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_a128ad00_15ac_49d7_961b_61558f7b2a3d
is: SBO:0000252
type: Species
name: LDHC
is: P07864
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:3948
initial amount: NaN
boundary condition: true

metaR DADA
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
name: Deoxyadenosine deaminase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false

metaM thym c
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
has only substance units: false
is: HMDB00262
is: C00178
boundary condition: false
name: Thymine
initial amount: NaN
is: SBO:0000247
is: CHEBI:17821
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_2875ce47_0cd6_41de_b80f_ea35bd8f4ad9
is: Q3MHC9
is: SBO:0000252
name: SKIV2L2
has only substance units: false
is encoded by: hsa:23517
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_df132203_e944_4c33_892c_6d5a8e2c820f
is: SBO:0000252
constant: false
is encoded by: hsa:10935
has only substance units: false
is: E9PH29
type: Species
name: PRDX3
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM o2 c
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
is: SBO:0000247
is: C00007
is: CHEBI:15379
initial amount: NaN
constant: false
type: Species
name: O2
is: HMDB01377
has only substance units: false

metaR FAOXC226C227m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_b32d29fd_b749_44b9_a95e_58a921b64bbd
is encoded by: hsa:4698
is: Q16718
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: NDUFA5
initial amount: NaN
type: Species

metaM stcoa c
constant: false
type: Species
is: CHEBI:57394
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
name: Stearoyl-CoA (n-C18:0CoA)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00412
has only substance units: false
is: HMDB01114
boundary condition: false

metaR r0643
kinetic law: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110047#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
reactant: MODEL1310110047#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
boundary condition: false
is: CHEBI:57847
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
name: Type IIIA glycolipid
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00304
constant: false

metaM 4hexdtricoa m
name: 4,7,10-hexadecatrienoylcoa
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
is: HMDB02288
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR NH4tp
reactant: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: ammonia peroxisomal transport
kinetic law: MODEL1310110047#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false

metaR r2087
product: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false

metaM bilirub r
is: HMDB00054
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57977
type: Species
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_d5348550_47cf_4e01_b05a_1ce2487dfce0
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ALDH7A1
initial concentration: NaN
type: Species
constant: false
is: E7EPT3
has only substance units: false
is encoded by: hsa:501

metaM dcacoa x
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB06404
initial amount: NaN
is: C05274
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
constant: false

metaM 5htrp c
is: SBO:0000247
initial concentration: 1.0
name: 5-hydroxy-L-tryptophan
initial amount: NaN
is: CHEBI:17780
type: Species
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
boundary condition: false
is: HMDB00472
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_6aa7f216_2a5d_43e8_a949_8cf9683d14cf
name: SLC5A11
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:115584
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q8WWX8

metaR r0644
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110047#
fast: false

metaR r2088
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
reversible: true

metaM ditp c
is: CHEBI:61382
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
has only substance units: false
boundary condition: false
constant: false
is: HMDB03537
initial concentration: 1.0
type: Species
name: dITP(4-)
is: SBO:0000247

metaR r1944
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: Y+LAT2 Utilized transport

metaM doco13ac e
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB02068
name: docosenoic acid (C22:1)
initial amount: NaN
notes: FORMULA: C22H41O2 CHARGE: -1
has only substance units: false
type: Species

metaM dcmp c
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
is: SBO:0000247
is: C00239
name: dCMP
is: HMDB01202
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:57566

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_e4f171ff_a412_45a4_a593_84c7583c11c4
initial amount: NaN
is: O95498
is encoded by: hsa:8875
name: VNN2
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_cd2fcb29_0597_486e_96a3_e518bce9a2fd
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6817
name: SULT1A1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaM 3dhguln c
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57655
is: HMDB06334
name: 3-dehydro-L-gulonate
has only substance units: false
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110047#_4d446e74_0bfc_4606_af95_4a1fdd495603
boundary condition: true
is: P50747
initial concentration: NaN
type: Species
name: HLCS
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3141
initial amount: NaN

metaM gluside hs l
initial concentration: 1.0
has only substance units: false
name: D-glucosyl-N-acylsphingosine
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
constant: false
type: Species
is: CHEBI:18368
initial amount: NaN

metaR r0645
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
name: 2-Aminomuconate semialdehyde:NAD+ 6-oxidoreductase Tryptophan metabolism EC:1.2.1.32
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.32 Confidence Level: 0 AUTHORS: NOTES:
fast: false
type: Reaction
reactant: MODEL1310110047#
is: SBO:0000176

metaR r2085
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR GHMT2rm
product: MODEL1310110047#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110047#
type: Reaction
is described by: ECO:0000269

metaR HPDCACRNt
reversible: false
name: heptadecanoate transport into the mitochondria
modifier: MODEL1310110047#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110047#
product: MODEL1310110047#

metaR BTNtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000000
type: Reaction
name: Biotin transport, nuclear
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185

metaM ksi deg3 l
is: HMDB00573
name: keratan sulfate I, degradation product 3
boundary condition: false
type: Species
is: CHEBI:30825
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_78ff5d3f_70a3_43ca_957d_1b644a2cca85
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110047#_ff973980_5f0e_4691_95ea_94ccfd3576b5
initial concentration: NaN
name: ACADSB
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: P45954
constant: false
is encoded by: hsa:36
boundary condition: true

metaR r0791
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reversible: true

metaM digalside hs l
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8383
initial amount: NaN
type: Species
is: SBO:0000247
name: Digalactosylceramide
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
is: C06126
has only substance units: false
constant: false

metaR FAOXC5C3x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_0cbc3eec_378a_4bec_b0b5_aeed5669c6c8
initial concentration: NaN
constant: false
has only substance units: false
name: ATP1B4
is encoded by: hsa:23439
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9UN42
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_6110df67_a76c_41b3_88b4_d0f9a3d9be1e
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:J03866
constant: false
is: SBO:0000252
name: _J03866_1_m
has only substance units: false
initial concentration: NaN

metaR r2086
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_5f00b108_9af5_47c0_b0cb_34624d2acf99
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:NM 013421
initial concentration: NaN
constant: false
name: _NM_013421_1_e

metaM ksi deg32 l
name: keratan sulfate I, degradation product 32
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
is: CHEBI:12936
is: HMDB00143
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r0792
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
reversible: true
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20

metaM pe hs m
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
boundary condition: false
name: phosphatidylethanolamine
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_ceccc779_131f_4e0f_93d8_d522dd0eea14
initial amount: NaN
constant: false
is encoded by: hsa:29922
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NME7

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaM CE4790 m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57923
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA

metaR AKR1C1
type: Reaction
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
product: MODEL1310110047#
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.1.20
reversible: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR UDPGD
modifier: MODEL1310110047#
is described by: ECO:0000304
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
is: SBO:0000176
name: UDPglucose 6-dehydrogenase
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.22
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_13054592_b66e_49b0_b7ef_c6c3d81d7e8d
is: SBO:0000252
type: Species
is: P15531
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:4830
initial amount: NaN
name: NME1

metaR r2083
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110047#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM hom L e
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
constant: false
is: HMDB00719
has only substance units: false
is: SBO:0000247
boundary condition: false
name: L-homoserine
initial concentration: 1.0

metaM ksii core2 pre9 g
has only substance units: false
is: CHEBI:28067
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 9
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
constant: false
type: Species

metaM btcoa c
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57371
name: Butanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01088
is: C00136

metaM CE2433 m
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57795
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
type: Species
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA

metaR CYSO
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is described by: ECO:0000269
name: cysteine oxidase
product: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.13.11.20
fast: false

metaM cs e deg6 l
has only substance units: false
constant: false
type: Species
is: HMDB00812
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16953
boundary condition: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6

metaM ocdececrn m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB06351
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
name: 11-octadecenoyl carnitine

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR ACITL
modifier: MODEL1310110047#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.3.8
is: SBO:0000176
name: ATP-Citrate lyase
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_7500ffec_138b_4cb9_84fc_d105777deb91
name: NDUFS5
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q6IBA0
is encoded by: hsa:4725
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_a1e2f305_e94b_4aa2_a681_76790e227a9a
is encoded by: hsa:59272
type: Species
name: ACE2
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: C7ECU1

metaR r2084
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#

metaM gluside hs g
boundary condition: false
name: D-glucosyl-N-acylsphingosine
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:18368
type: Species
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR XYLUR
type: Reaction
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.10
is described by: ECO:0000269
modifier: MODEL1310110047#
name: xylulose reductase
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_d5dcd883_350e_4869_8ce0_dd4eb1d57d9b
is: SBO:0000252
name: NDUFS4
boundary condition: true
is encoded by: hsa:4724
is: O43181
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR FAOXC18280m
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
is: SBO:0000176
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR FAOXC225m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR r0641
is: SBO:0000176
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
kinetic law: MODEL1310110047#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
modifier: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.2.4
reactant: MODEL1310110047#
reversible: true
type: Reaction
fast: false

metaM HC01361 e
is: CHEBI:17001
has only substance units: false
name: Dihydroneopterin
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

metaR NACHEX10ly
product: MODEL1310110047#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110047#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110047#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_d5c00ad6_6ed1_403c_94e2_92ffa50fa699
initial amount: NaN
is encoded by: hsa:55312
constant: false
initial concentration: NaN
is: B2RDZ2
name: RFK
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR C81CPT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaM fprica c
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01439
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: C04734
is: CHEBI:58467
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN

metaM stcrn c
has only substance units: false
name: stearoylcarnitine
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
is: HMDB00848
initial amount: NaN

metaM thbpt4acam c
type: Species
is: CHEBI:15374
initial concentration: 1.0
is: HMDB02281
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
constant: false
has only substance units: false

metaR r2081
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1088
fast: false
product: MODEL1310110047#
name: Active transport
reversible: true
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction

metaR FAOXC5C5OHm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR HSPASEly
reversible: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)
is: SBO:0000176
type: Reaction
product: MODEL1310110047#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD

metaR r0642
kinetic law: MODEL1310110047#
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
type: Reaction

metaR r0795
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.225
reactant: MODEL1310110047#
is: SBO:0000176
name: Spontaneous reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110047#
fast: false

metaR ATPtx
type: Reaction
product: MODEL1310110047#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: ATP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000

metaM lnlncacrn m
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
type: Species
is: HMDB06319
name: alpha-linolenyl carnitine
initial concentration: 1.0

metaM pmtcoa c
type: Species
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
is: HMDB01338
is: CHEBI:3454
constant: false
boundary condition: false
is: C00154
initial amount: NaN

metaR LINOFATPtc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_6cdb8253_a4db_449c_bb67_0ccca834456d
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:226
constant: false
type: Species
is: SBO:0000252
name: ALDOA
initial amount: NaN

metaM dttp e
initial concentration: 1.0
constant: false
type: Species
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
is: CHEBI:37568
has only substance units: false
is: SBO:0000247
name: dTTP(4-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_0880b858_3b02_4c6f_a5a5_f835aabd7567
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:635
is: SBO:0000252
name: BHMT
has only substance units: false
is: Q93088
boundary condition: true

metaR MEVK1c
is described by: ECO:0000134
name: mevalonate kinase (atp) cytosol
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.36
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
kinetic law: MODEL1310110047#
type: Reaction
reversible: false

metaR r2082
product: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR RE1709C
kinetic law: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
fast: false
reactant: MODEL1310110047#
reversible: true
is: SBO:0000176
product: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_5dba5001_913a_46c8_88f2_0053f20d5215
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:U52111
is: SBO:0000252
name: _U52111_1_c

http://identifiers.org/biomodels.db/MODEL1310110047#_c9304f40_d27e_4a24_b395_169ceaee00ce
name: ASPA
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q6FH48
is encoded by: hsa:443

metaM ksi pre19 g
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 19
initial amount: NaN
has only substance units: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: HMDB00175
type: Species
boundary condition: false
is: C00130
is: CHEBI:58053
initial concentration: 1.0

metaR GLUTCOAACBP
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR PALFATPtc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ed6045ef_59bd_432b_94a0_d537d15c89f1
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: PANK2
is encoded by: hsa:80025
is: SBO:0000252

metaM cortsn r
name: cortisone
is: CHEBI:16962
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
type: Species
has only substance units: false
is: HMDB02802
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false

metaM HC01408 m
type: Species
constant: false
has only substance units: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
boundary condition: false
is: CHEBI:27648
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3-Oxohexanoyl-CoA

metaR S3TASE3ly
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false
reactant: MODEL1310110047#
reversible: true
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176

metaM ocdca e
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
is: HMDB00827
initial amount: NaN
name: octadecanoate (n-C18:0)
is: CHEBI:25629
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r0796
type: Reaction
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110047#

metaM srtn c
boundary condition: false
type: Species
is: CHEBI:350546
is: SBO:0000247
is: HMDB00259
name: serotonin(1+)
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_16e38f13_0d96_42f5_905a_74e6af3b233d
name: GCH1
type: Species
constant: false
initial amount: NaN
is: Q8IZH9
is encoded by: hsa:2643
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM HC01415 m
type: Species
is: CHEBI:27537
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
is: SBO:0000247
initial concentration: 1.0
name: (2E)-Octenoyl-CoA
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r2080
kinetic law: MODEL1310110047#
is: SBO:0000185
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110047#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110047#
is described by: ECO:0000000

metaM gluside hs c
name: D-glucosyl-N-acylsphingosine
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
initial amount: NaN
is: CHEBI:18368
has only substance units: false
boundary condition: false

metaR RE3269C
reversible: true
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is described by: ECO:0000000
modifier: MODEL1310110047#
is: SBO:0000176
type: Reaction
name: RE3269
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.48

http://identifiers.org/biomodels.db/MODEL1310110047#_161cdcb5_b6ea_4985_8642_bea84b71af50
initial concentration: NaN
constant: false
is: B7Z428
name: GNE
has only substance units: false
initial amount: NaN
is encoded by: hsa:10020
type: Species
is: SBO:0000252
boundary condition: true

metaR CYSTHRNaEx
is: SBO:0000185
modifier: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#
fast: false
type: Reaction
product: MODEL1310110047#
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110047#

metaM dttp c
is: HMDB01342
is: CHEBI:37568
name: dTTP
is: C00459
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c0bc1d6b_8b70_4bdb_972b_4cb530d9c128
constant: false
initial concentration: NaN
name: PIGN
is encoded by: hsa:23556
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR RE1709N
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
product: MODEL1310110047#
is described by: ECO:0000000
reversible: true
name: RE1709
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110047#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_52a8a667_4139_4f2c_8749_fc6cfe8b50bd
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: HK1
constant: false
is encoded by: hsa:3098
is: P78542
has only substance units: false

metaR 41R1H2MAE12BOOX
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000269
product: MODEL1310110047#
is: SBO:0000176
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
type: Reaction
reversible: false
modifier: MODEL1310110047#

metaR r0797
is version of: http://identifiers.org/ec-code/1.2.1.5
name: glycine N-choloyltransferase EC:2.3.1.65
is: SBO:0000176
kinetic law: MODEL1310110047#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:

metaM 10fthf6glu e
is: HMDB00972
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](6)
is: CHEBI:57454

metaR XYLTt
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110047#
reversible: true
type: Reaction
name: Xylitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110047#_fdf3e31f_44f2_4dc8_b304_a564aada636d
is: SBO:0000252
is: Q16831
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: UPP1
is encoded by: hsa:7378
initial concentration: NaN

metaM hom L c
initial amount: NaN
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
boundary condition: false
is: HMDB00719
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false

metaR ATPtm
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
reversible: false
product: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
type: Reaction
reactant: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
name: ADP/ATP transporter, mitochondrial

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_058a8014_7a8f_497a_8185_619874579bbf
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:259230
boundary condition: true
name: SGMS1
is: D3DWC4
is: SBO:0000252
initial amount: NaN

metaM srtn e
has only substance units: false
boundary condition: false
is: CHEBI:350546
type: Species
is: SBO:0000247
is: HMDB00259
constant: false
initial amount: NaN
initial concentration: 1.0
name: serotonin(1+)
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

http://identifiers.org/biomodels.db/MODEL1310110047#_c7056e3d_3c44_4690_8d9e_e77d8597ad68
has only substance units: false
constant: false
is encoded by: hsa:55350
initial amount: NaN
initial concentration: NaN
type: Species
name: VNN3
is: SBO:0000252
boundary condition: true

metaM ocdca c
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
is: HMDB00827
initial amount: NaN
boundary condition: false
is: CHEBI:25629
has only substance units: false
type: Species
name: stearate
initial concentration: 1.0
constant: false

metaM 3hdcoa m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
initial amount: NaN
boundary condition: false
name: (S)-3-Hydroxydecanoyl-CoA
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false

metaR LINKDEG4ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
type: Reaction
reversible: false
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110047#_0997de5a_153f_4218_bb47_4ce969208979
has only substance units: false
initial amount: NaN
name: DLD
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P09622
is encoded by: hsa:1738
constant: false

metaM m1mpdol U c
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
is: SBO:0000247
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_6ebdabb0_3bfe_4e45_b249_fe1984d7b491
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI697028
initial concentration: NaN
initial amount: NaN
constant: false
name: _AI697028_1_e

metaM 3pg c
name: 3-Phospho-D-glycerate
is: http://identifiers.org/pubchem.compound/3497
is: C00197
constant: false
has only substance units: false
is: CHEBI:58272
is: HMDB00807
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_baf558e2_0d7e_4e6a_812c_0dc20e066a68
constant: false
is encoded by: hsa:1595
is: Q16850
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: CYP51A1

http://identifiers.org/biomodels.db/MODEL1310110047#_695bc412_2516_4b58_8b0a_911a1765db8c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: Q8WXF9
name: SLC2A11
constant: false
is encoded by: hsa:66035
initial amount: NaN

metaR PPM
product: MODEL1310110047#
name: phosphopentomutase
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
reversible: true

metaR URIt5le
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110047#
name: uridine transport in via sodium symport (1:2)
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_a9030ea0_bcea_428f_ab66_dd8ad759e469
boundary condition: true
constant: false
type: Species
name: PLCH1
has only substance units: false
initial amount: NaN
is: Q4KWH8
is encoded by: hsa:23007
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_2a3fac43_3092_43a5_9a0f_28954df6df83
is: P43155
is: SBO:0000252
is encoded by: hsa:1384
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CRAT
has only substance units: false
type: Species
constant: false

metaM dcacoa m
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
is: SBO:0000247
initial concentration: 1.0
is: HMDB06404
boundary condition: false
is: C05274
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species
constant: false
has only substance units: false

metaR PVD3
type: Reaction
is described by: ECO:0000134
reversible: true
name: Previtamin D3 formation
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176

metaM xol7ah2al c
has only substance units: false
is: CHEBI:27428
constant: false
is: HMDB06894
is: SBO:0000247
type: Species
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445

http://identifiers.org/biomodels.db/MODEL1310110047#_d675773e_5482_495a_9ae7_5aa4386cc47d
has only substance units: false
name: NME3
is: Q13232
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:4832

http://identifiers.org/biomodels.db/MODEL1310110047#_4d40a76b_f4e9_47f7_a57d_32d9d4f62efb
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:30
name: ACAA1
is: Q96CA6
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM pe hs e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: phosphatidylethanolamine
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038

metaM thbpt4acam n
boundary condition: false
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_45dc17ef_dd68_4f6a_a9f3_c5abc3c984d1
initial concentration: NaN
constant: false
is: P00439
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PAH
is encoded by: hsa:5053
type: Species
initial amount: NaN

metaR FACOAL40im
notes: GENE_ASSOCIATION: (116285.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES:JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD
is version of: http://identifiers.org/ec-code/6.2.1.2
type: Reaction
reactant: MODEL1310110047#
modifier: MODEL1310110047#
name: fatty-acid--CoA ligase (butanoate), mitochondrial
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
is described by: ECO:0000269

metaR DPPS
product: MODEL1310110047#
reversible: false
is described by: ECO:0000134
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: decaprenyl synthase
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM btn n
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: CHEBI:57586
initial amount: NaN
boundary condition: false
has only substance units: false
name: biotinate
is: HMDB00030
is: SBO:0000247

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

metaM prostgd2 e
is: HMDB01403
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: prostaglandin D2(1-)
is: CHEBI:57406
has only substance units: false

metaR S2L2N2M2MASNtly
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
name: s2l2n2m2masn transport, extracellular to lysosome
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_8f4591d7_921a_4f06_83ac_75fddcfc141c
type: Species
initial concentration: NaN
constant: false
is: P51828
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:113
name: ADCY7
initial amount: NaN

metaR FAOXC225x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaR ARGDCm
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
name: arginine decarboxylase (m)
is version of: http://identifiers.org/ec-code/4.1.1.19
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (113451.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.19 Confidence Level: 4 AUTHORS: PMID:14752610 NOTES:SAB m
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_6878f7a1_4ef5_4689_af70_55e818c5448c
type: Species
is: O14734
constant: false
is encoded by: hsa:10005
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ACOT8

metaM lnlncacrn c
name: alpha-linolenyl carnitine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06319
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1

metaM 4hexdtricoa x
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: HMDB02288
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 4,7,10-hexadecatrienoylcoa
type: Species

metaM ksii core2 deg6 l
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 6
initial amount: NaN
constant: false
type: Species
is: CHEBI:12936
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110047#_0a646d46_a1fc_417e_b33e_b04508aba22a
is: E5KSL5
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: DGUOK
type: Species
is encoded by: hsa:1716
initial concentration: NaN
has only substance units: false

metaM btn m
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: biotinate
is: HMDB00030
is: CHEBI:57586
is: SBO:0000247
boundary condition: false

metaM hs deg9 l
constant: false
initial amount: NaN
is: CHEBI:18268
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
type: Species
has only substance units: false
is: HMDB06355
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: heparan sulfate, degradation product 9

metaR FAOXC164C143x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaM cs a deg1 l
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16953
is: HMDB00812
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
constant: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
boundary condition: false

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_d9d3b039_952e_4202_b6ee_bf55ee9b6bcf
type: Species
constant: false
is: SBO:0000252
name: EHHADH
has only substance units: false
initial amount: NaN
is: Q9NY65
boundary condition: true
is encoded by: hsa:1962
initial concentration: NaN

metaR C14OHc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaM pe hs c
is: CHEBI:16038
has only substance units: false
name: phosphatidylethanolamine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
type: Species
initial amount: NaN

metaM CE1939 e
is: CHEBI:36781
name: spermidine monoaldehyde 1
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939

metaM stcoa m
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
is: CHEBI:57394
has only substance units: false
is: C00412
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_ab9ef7ca_f5cf_4daf_bcf7_917508448f02
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:4712
is: SBO:0000252
type: Species
has only substance units: false
is: Q5VYT2
boundary condition: true
name: NDUFB6

metaM prostgd2 c
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01403
initial amount: NaN
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
is: CHEBI:57406

http://identifiers.org/biomodels.db/MODEL1310110047#_40b0c9b4_9a39_4b6a_877b_c3db27bd9fd7
type: Species
constant: false
is encoded by: hsa:7390
is: SBO:0000252
is: P10746
boundary condition: true
name: UROS
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR CHOLK
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110047#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: Choline kinase
modifier: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.32

http://identifiers.org/biomodels.db/MODEL1310110047#_bcd0d0ba_ffdb_4140_afc0_f9f87c5a4d11
is encoded by: hsa:10087
has only substance units: false
boundary condition: true
is: Q9Y5P4
initial concentration: NaN
is: SBO:0000252
name: COL4A3BP
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_46c2e4f3_cd0c_441a_a248_591ce4b98ede
boundary condition: true
is: Q02127
initial concentration: NaN
constant: false
type: Species
name: DHODH
initial amount: NaN
is encoded by: hsa:1723
has only substance units: false
is: SBO:0000252

metaR 3MOBte
type: Reaction
name: Transport of 3-methyl-2-oxobutanoate
fast: false
is described by: ECO:0000134
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_12e53149_bfbc_43c4_a0a0_4da51ab85359
type: Species
is: SBO:0000252
boundary condition: true
is: P00558
initial amount: NaN
initial concentration: NaN
name: PGK1
has only substance units: false
constant: false
is encoded by: hsa:5230

metaM m2mpdol U c
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
is: CHEBI:28049
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR S2TASE2ly
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
reversible: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_62ae8488_3684_4fcd_b033_b8a2144dfed8
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9H6Y6
boundary condition: true
name: MYO5B
is encoded by: hsa:4645
initial amount: NaN

metaR RE3004M
name: RE3004
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is described by: ECO:0000269
reversible: true
name: L-carnitine reversible transport
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_fed174eb_04d0_4f6e_9d5b_126bc3da5840
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: SLC7A1
is: P30825
initial amount: NaN
boundary condition: true
is encoded by: hsa:6541
initial concentration: NaN

metaM C05957 r
name: Prostaglandin J2
has only substance units: false
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: SBO:0000247
is: CHEBI:27485
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02710

metaR r0549
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.6.99.3
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.1.1.17
modifier: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.6.5.3
is described by: ECO:0000000
fast: false

metaR TYROXDAc
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
reversible: false
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110047#
fast: false

metaR ARGtm
reactant: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110047#
name: arginine mitochondrial transport via ornithine carrier

metaM 4hexdtetcoa m
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB02288
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 4,7,10,13-hexadecatetraenoylcoa
constant: false

metaR r1384
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: Guanosine aminohydrolase EC:3.5.4.15
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#

metaR FAOXTC142TC122m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_8cafa466_af64_461c_96e1_f40a8bf8dbd9
is encoded by: hsa:1491
is: SBO:0000252
initial amount: NaN
constant: false
is: B4E1R2
type: Species
initial concentration: NaN
boundary condition: true
name: CTH
has only substance units: false

metaR NCNt
kinetic law: MODEL1310110047#
is: SBO:0000185
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-NH4+ exchange
reversible: true
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#

metaM btn c
has only substance units: false
is: SBO:0000247
is: CHEBI:3420
is: C00120
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
name: Biotin
type: Species
initial amount: NaN
is: HMDB00030

metaR TTDCPT1
kinetic law: MODEL1310110047#
reversible: false
type: Reaction
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110047#
reactant: MODEL1310110047#

metaM biocyt c
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C05552
is: HMDB03134
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR FAOXC226C225x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_e9ac071c_d03d_47c1_ab1a_44b3732409e5
initial amount: NaN
is encoded by: hsa:27068
type: Species
name: PPA2
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaR r0879
fast: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
is described by: ECO:0000000
product: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
reversible: false

metaM gtp c
is: SBO:0000247
is: C00044
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01273
has only substance units: false
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
initial concentration: 1.0
is: CHEBI:37565

http://identifiers.org/biomodels.db/MODEL1310110047#_706fc7e1_c4e4_4e8d_9956_12753b76f2c0
is encoded by: hsa:29922
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: NME7
type: Species
is: SBO:0000252
is: Q9Y5B8
has only substance units: false

metaM pheacgln e
is: HMDB06344
is: CHEBI:58310
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
type: Species
constant: false

metaR FRDPtr
is: SBO:0000185
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110047#
fast: false
type: Reaction
reactant: MODEL1310110047#

metaR G14T13g
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM gpail hs c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
type: Species
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
is: CHEBI:17049
initial amount: NaN
constant: false

metaM 2dp6mobq me m
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
initial amount: NaN
is: CHEBI:50772
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_36528208_4532_44a0_9a7e_a9b41dfab23b
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:54344
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: Q9P2X0
name: DPM3

metaR PTE4x
modifier: MODEL1310110047#
reversible: false
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.2.2
name: peroxisomal acyl-CoA thioesterase
is described by: ECO:0000269
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176

metaR TTDCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
name: carnitine transferase
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false
product: MODEL1310110047#

metaM succ e
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
has only substance units: false
boundary condition: false
is: HMDB00254
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30031
type: Species
initial amount: NaN
name: succinate(2-)

metaR ARACHDtr
product: MODEL1310110047#
name: intracellular transport
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_3b40461f_66ff_4e07_987e_cad15d5c381b
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: OCRL
type: Species
is: Q01968
initial amount: NaN
constant: false
is encoded by: hsa:4952
has only substance units: false

metaR ASAH1
is version of: http://identifiers.org/ec-code/3.5.1.23
reactant: MODEL1310110047#
type: Reaction
name: N-acylsphingosine amidohydrolase
reversible: false
modifier: MODEL1310110047#
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
is described by: ECO:0000000

metaR UGALNACtg
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#
name: UDP-GalNAc Golgi transport via CMP antiport
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000269

metaM hpyr c
constant: false
boundary condition: false
is: HMDB01352
is: CHEBI:17180
name: 3-hydroxypyruvate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: SBO:0000247
has only substance units: false
type: Species

metaR FAOXC61x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaM pcrn m
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial concentration: 1.0
is: HMDB00824
name: propionyl-carnitine
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/107738

metaM xoltriol c
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16496

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_0b74ba18_fa31_4078_b3a2_9e621c5cb12e
initial concentration: NaN
has only substance units: false
is: P00414
initial amount: NaN
name: COX3
boundary condition: true
is encoded by: hsa:4514
constant: false
type: Species
is: SBO:0000252

metaR RE3556C
is: SBO:0000176
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
name: RE3556
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaM crm hs r
type: Species
has only substance units: false
name: N-acylsphingosine
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
is: SBO:0000247

metaM btn e
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
is: HMDB00030
is: SBO:0000247
is: CHEBI:3420
is: C00120
constant: false
name: Biotin
initial amount: NaN
has only substance units: false
boundary condition: false

metaR GLCNACASE1ly
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
fast: false
product: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.50

http://identifiers.org/biomodels.db/MODEL1310110047#_2ab501d8_e31c_4b85_a58e_e84d9b3b7daf
name: PIGA
initial amount: NaN
is: P37287
type: Species
is encoded by: hsa:5277
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_2c048415_e2d2_40fd_84d6_bdbe8c3d453c
initial amount: NaN
is encoded by: hsa:3032
has only substance units: false
boundary condition: true
name: HADHB
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: P55084

metaM 6thf e
constant: false
initial amount: NaN
name: hexaglutamyl folate (THF)
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: http://identifiers.org/pubchem.compound/169691
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM ivcoa m
initial concentration: 1.0
name: Isovaleryl-CoA
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
type: Species
is: HMDB01113
has only substance units: false
is: CHEBI:57345
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaR TDP
is: SBO:0000176
reversible: false
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: thiamin pyrophosphatase
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:2171493,PMID:8522961 NOTES:_01-25-05 IT AMF

http://identifiers.org/biomodels.db/MODEL1310110047#_49c940db_59f6_450f_af4b_f596b4aba157
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1607
initial amount: NaN
has only substance units: false
is: Q9Y6T7
name: DGKB
constant: false

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM pdx5p c
is: C00627
initial amount: NaN
is: CHEBI:58589
is: SBO:0000247
is: HMDB01319
initial concentration: 1.0
type: Species
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
boundary condition: false
name: Pyridoxine 5'-phosphate
constant: false
has only substance units: false

metaM pheacgln c
is: HMDB06344
constant: false
is: CHEBI:58310
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
type: Species

metaM sql r
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00256
is: SBO:0000247
name: squalene
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:15440

http://identifiers.org/biomodels.db/MODEL1310110047#_38cf604e_c2c6_4bdd_a790_e8b31cf13c4e
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: GGT1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2678
boundary condition: true
is: P19440

http://identifiers.org/biomodels.db/MODEL1310110047#_bec5aa2b_6dcc_4c4b_9396_34a64b817d9a
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: BAAT
is: SBO:0000252
is encoded by: hsa:570
is: Q14032

metaM leuktrE4 e
boundary condition: false
is: HMDB02200
is: CHEBI:57462
name: leukotriene E4(1-)
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_0baf47b5_3bc4_4519_8f77_7aef486436a6
is encoded by: hsa:9791
name: PTDSS1
constant: false
is: P48651
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r0545
is described by: ECO:0000000
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
type: Reaction
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_58199e62_6d3f_47c7_bbc9_8689f777b523
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:10455
name: ECI2
is: SBO:0000252
is: O75521
constant: false
initial amount: NaN

metaR FMNALKPle
is: SBO:0000176
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
reversible: false
is described by: ECO:0000134
type: Reaction
name: FMNALKPle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110047#

metaM so3 c
is: HMDB00240
is: SBO:0000247
boundary condition: false
type: Species
is: C00094
is: CHEBI:17137
initial concentration: 1.0
name: Sulfite
constant: false
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial amount: NaN

metaM oxa m
has only substance units: false
is: SBO:0000247
type: Species
name: oxalate(2-)
boundary condition: false
initial amount: NaN
is: HMDB02329
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_5ce4a5cc_0870_4c44_aa63_7417c5a2d318
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9UMR5
has only substance units: false
constant: false
name: PPT2
boundary condition: true
is encoded by: hsa:9374
initial amount: NaN

metaR P5CDm
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
product: MODEL1310110047#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_a40f9d84_de8b_4046_b858_220584d3c8f8
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:883
initial concentration: NaN
has only substance units: false
type: Species
is: Q16773
name: CCBL1
initial amount: NaN

metaM pheme e
initial amount: NaN
is: HMDB03178
is: SBO:0000247
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
has only substance units: false
name: Protoheme
initial concentration: 1.0
constant: false
is: CHEBI:17627
boundary condition: false
is: C00032
type: Species

metaR GALt1r
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
product: MODEL1310110047#
name: galactose transport (uniport)
fast: false
reversible: true
modifier: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_3b38fed0_39cb_4fa2_aebf_f0674fc43e09
is: P43166
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:766
name: CA7
type: Species
is: SBO:0000252
boundary condition: true

metaR FAOXC143C123x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaM Rtotal3coa c
is: CHEBI:16189
is: HMDB01448
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: R total 3 Coenzyme A
constant: false

metaR C140CPT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaM 3hmbcoa m
initial concentration: 1.0
has only substance units: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: HMDB01356
is: CHEBI:57312
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
boundary condition: false
initial amount: NaN

metaR r0758
is described by: ECO:0000000
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
is: SBO:0000176
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_051ab238_6c31_4898_a248_14ff65744793
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AA502753
name: _AA502753_1_m

metaR GLYLEUPEPT1tc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_5bb87227_29c5_4867_a14d_1980c7bd1a7b
boundary condition: true
name: PFKL:PFKP
is encoded by: hsa:5211
constant: false
type: Species
initial amount: NaN
has part: Q7L2M7
initial concentration: NaN
is: SBO:0000297
has only substance units: false

metaR HEXDICOAACBP
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM cs e deg2 l
has only substance units: false
is: SBO:0000247
is: HMDB00812
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
constant: false
is: CHEBI:16953
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_325ade8e_ff4b_4236_ab70_ef70a8d491dd
constant: false
is encoded by: hsa:5214
boundary condition: true
has only substance units: false
is: Q5VSR7
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PFKP
type: Species

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaM gsn c
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
type: Species
is: CHEBI:16750
is: HMDB00133
name: Guanosine
boundary condition: false
has only substance units: false
is: C00387
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM Nacasp c
is: HMDB00812
type: Species
initial amount: NaN
name: N-acetyl-L-aspartate(2-)
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16953
initial concentration: 1.0
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
has only substance units: false

metaM ksi pre36 g
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
boundary condition: false
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 36

metaR PGLYCt
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
kinetic law: MODEL1310110047#
name: phosphatidylglycerol transport
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110047#_875f4adb_5075_4946_8438_a49097eeb62a
is: SBO:0000252
type: Species
name: COQ2
is: Q96H96
initial amount: NaN
is encoded by: hsa:27235
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_e9353f65_dcbd_4970_a97d_3bc137504b1e
is encoded by: hsa:4706
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFAB1
has only substance units: false
constant: false
is: O14561

http://identifiers.org/biomodels.db/MODEL1310110047#_6490c9ca_ac14_488b_b1b6_685fcc506f86
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: GCDH
has only substance units: false
is: Q92947
is encoded by: hsa:2639

metaM Rtotalcoa c
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: SBO:0000247
is: CHEBI:16189
is: HMDB01448
boundary condition: false
initial concentration: 1.0
name: R total Coenzyme A
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaM pheme c
type: Species
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
has only substance units: false
initial amount: NaN
name: Protoheme
is: HMDB03178
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17627
constant: false
boundary condition: false
is: C00032

http://identifiers.org/biomodels.db/MODEL1310110047#_b7a8f46f_4c9b_4b1d_b2bd_eb9e10ae4ddd
is: SBO:0000252
initial concentration: NaN
type: Species
is: P09960
initial amount: NaN
boundary condition: true
name: LTA4H
has only substance units: false
is encoded by: hsa:4048
constant: false

metaM biliverd c
name: biliverdin(2-)
initial amount: NaN
is: HMDB01008
boundary condition: false
constant: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial concentration: 1.0
type: Species
is: CHEBI:57991
has only substance units: false
is: SBO:0000247

metaR GPIDAer
kinetic law: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
is: SBO:0000176

metaR ETFQO
reversible: false
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.5.1

metaR NKCCt
fast: false
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6557.1) or (6558.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10617769,PMID:12657561,PMID:12739168,PMID:7629105,PMID:8640224 NOTES:NCD
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
name: Na+-K+-Cl- cotransport
reversible: true

metaM gtp e
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
constant: false
name: GTP(4-)
is: HMDB01273
type: Species
is: CHEBI:37565
initial amount: NaN

metaR S6T6g
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
reversible: false
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110047#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_04119dda_b27c_437a_aafd_b8edee8c77d2
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:AA576959
name: _AA576959_1_c

metaR ACACT1rm
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
modifier: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
is described by: ECO:0000000

metaR FALDtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reactant: MODEL1310110047#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: formaldehyde transport via diffusion (mitochondrial)
fast: false
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_4e45db12_f4c8_4883_b181_4b295bdd0932
is encoded by: hsa:10317
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9Y2C3
has only substance units: false
name: B3GALT5
boundary condition: true
initial amount: NaN

metaM prostgi2 r
type: Species
boundary condition: false
is: CHEBI:57403
initial amount: NaN
is: SBO:0000247
is: HMDB01335
name: prostaglandin I2(1-)
constant: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0

metaR NACHEX12ly
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176

metaR UMPK4n
product: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110047#
type: Reaction
name: UMP kinase (GTP),nuclear
reactant: MODEL1310110047#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM CE2916 e
name: neocasomorphin
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C35H51N6O10 CHARGE: -1 INCHI: InChI=1/C35H52N6O10/c1-5-20(4)29(35(50)51)39-31(46)26-9-7-17-41(26)34(49)24(14-15-27(43)44)37-32(47)28(19(2)3)38-30(45)25-8-6-16-40(25)33(48)23(36)18-21-10-12-22(42)13-11-21/h10-13,19-20,23-26,28-29,42H,5-9,14-18,36H2,1-4H3,(H,37,47)(H,38,45)(H,39,46)(H,43,44)(H,50,51)/p-1/t20-,23+,24+,25+,26+,28-,29-/m0/s1 EHMN_ABBREVIATION: CE2916
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
boundary condition: false
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110047#_88623ce5_423d_4a7b_8f26_7147831b3f5c
is encoded by: hsa:205
initial amount: NaN
name: AK4
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM crm hs l
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:52639
name: N-acylsphingosine
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM HC01409 m
initial concentration: 1.0
is: CHEBI:27540
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
type: Species
name: Hexanoyl-CoA
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaR FACOAL1822
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
type: Reaction
is: SBO:0000176
name: fatty-acid--CoA ligase

metaR CYTK3n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r0541
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110047#
reversible: true
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7

metaR ARACHDCOAtx
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110047#
name: fatty acid intracellular transport
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM HC02204 c
name: prostaglandin-b1
is: SBO:0000247
is: CHEBI:27624
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
type: Species
constant: false

metaM ksii core2 pre2 g
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 2
is: SBO:0000247
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: CHEBI:58053
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00175
constant: false
is: C00130

metaM fmn c
is: CHEBI:58210
name: FMN
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial concentration: 1.0
initial amount: NaN
is: C00061
is: HMDB01520
boundary condition: false

metaR r2331
fast: false
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaM cs b deg1 l
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16953
is: HMDB00812
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1

http://identifiers.org/biomodels.db/MODEL1310110047#_8eb82303_a410_41d4_9bc8_e48bad3ac7df
type: Species
is: Q9HBF5
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:400410
name: ST20
is: SBO:0000252
initial amount: NaN

metaR FAOXC61m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ca595620_d91c_48c1_a85b_cc0fa0ca2f47
name: NME1
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4830

metaM hs deg21 l
is: SBO:0000247
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H55NO38S2 CHARGE: -4
type: Species
initial concentration: 1.0
is: CHEBI:16126
constant: false

metaR CYOOm3
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.9.3.1
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
modifier: MODEL1310110047#
name: cytochrome c oxidase, mitochondrial Complex IV
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_a313383e_9a46_4171_aaca_053ddf16d0d0
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:771
name: CA12
is: O43570
has only substance units: false
is: SBO:0000252

metaM succ m
initial concentration: 1.0
type: Species
is: CHEBI:30031
initial amount: NaN
is: HMDB00254
is: C00042
boundary condition: false
is: SBO:0000247
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
has only substance units: false

metaR FAOXC184C163x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR FACOAL1821
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
fast: false
name: fatty-acid--CoA ligase
reversible: true

metaR C161CPT22
reactant: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
name: C161 transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110047#_02ba2fea_6f1a_4b82_becf_9278525b70cc
initial amount: NaN
type: Species
is: Q96QD8
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: SLC38A2
is encoded by: hsa:54407
initial concentration: NaN

metaM fmn e
is: C00061
is: HMDB01520
boundary condition: false
is: CHEBI:58210
is: SBO:0000247
type: Species
name: FMN
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H19N4O9P CHARGE: -2
constant: false

metaR PIter
reversible: true
modifier: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000212
fast: false
name: phosphate transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110047#
is: SBO:0000185

metaR VALtec
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
name: L-valine transport via diffusion (extracellular to cytosol)
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185
kinetic law: MODEL1310110047#
fast: false

metaR COt
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
fast: false
product: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
type: Reaction
name: CO transporter via diffusion

metaR LNLNCGt
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110047#

metaR XOL7AH2tm
name: lipid, flip-flop intracellular transport
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#

metaM s2l2fn2m2masn g
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
is: HMDB00868
name: PA6
initial concentration: 1.0
is: CHEBI:57737
notes: FORMULA: C90H145N6O65X CHARGE: -2
initial amount: NaN

metaR r2330
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_15835a35_86ea_4fba_a520_63cc1e764e64
initial amount: NaN
name: RRM1
is: P23921
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6240

http://identifiers.org/biomodels.db/MODEL1310110047#_ed054e22_6765_4e6e_9596_af5476f15708
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR BHBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
product: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_6028e526_2740_4af3_b2a5_88465fe51717
constant: false
boundary condition: true
name: AMY1A
initial amount: NaN
is encoded by: hsa:276
initial concentration: NaN
is: Q6NSB3
has only substance units: false
is: SBO:0000252
type: Species

metaM spmd c
is: C00315
name: Spermidine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57834
initial amount: NaN
is: HMDB01257
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315

http://identifiers.org/biomodels.db/MODEL1310110047#_c9f073f6_bb60_42b2_a607_c517274d31ed
name: ACSL3
boundary condition: true
initial amount: NaN
is: O95573
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:2181
is: SBO:0000252

metaM tetpent3coa x
has only substance units: false
is: C16167
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-3
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaR BCDO
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110047#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
type: Reaction
modifier: MODEL1310110047#
name: beta-Carotene dioxygenase
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.14.99.36
product: MODEL1310110047#

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR RE3050R
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is described by: ECO:0000000
name: RE3050
type: Reaction
reversible: true
product: MODEL1310110047#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110047#

metaM cdp n
initial concentration: 1.0
constant: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58069

metaM ivcoa c
boundary condition: false
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
initial amount: NaN
name: Isovaleryl-CoA
is: HMDB01113
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR GALASE12ly
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: beta-galactosidase, lysosomal
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR r0434
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110047#
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#

metaM hs deg2 l
constant: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
type: Species
name: heparan sulfate, degradation product 2
is: CHEBI:17180
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01352
initial concentration: 1.0
is: SBO:0000247

metaR DM 5hpet LPAREN r RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for 5(S)-HPETE(1-)
type: Reaction

metaM 6dhf e
boundary condition: false
is: HMDB06563
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: SBO:0000247
name: hexaglutamyl folate (DHF)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_70af4486_72a7_4d80_88d2_4aa469857464
name: TSTA3
is encoded by: hsa:7264
is: SBO:0000252
type: Species
is: Q13630
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM xol7ah3 m
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: CHEBI:28540
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
constant: false
initial concentration: 1.0
has only substance units: false

metaR ADAe
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
name: Adenosine deaminase, extracellular
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is: SBO:0000176
reversible: false
is described by: ECO:0000269

metaM cdp m
is: HMDB01546
is: SBO:0000247
boundary condition: false
constant: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_e8b97af5_f282_4021_9e05_c60aafcd699d
initial amount: NaN
name: DHFR
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P00374
is: SBO:0000252
constant: false
is encoded by: hsa:1719
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_ee84adc2_595d_4e2a_ae87_d5c40cbc09ef
name: SULT1A1
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6817
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_a8171b21_2138_4195_acb9_e4dff85329fd
is encoded by: hsa:9107
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: MTMR6
boundary condition: true
is: Q9Y217

metaR r0647
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: Spontaneous reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
fast: false
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
reversible: true

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaM spmd e
name: Spermidine
is: HMDB01257
has only substance units: false
is: CHEBI:57834
type: Species
boundary condition: false
is: C00315
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315

metaM HC10852 r
is: SBO:0000247
initial amount: NaN
name: palmitoleyl-CoA(4-)
constant: false
type: Species
is: CHEBI:61540
boundary condition: false
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
initial concentration: 1.0

metaR FAOXC2442246x
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110047#_aad940af_175d_421b_afb4_cb19d3a641d8
name: TKTL1
has only substance units: false
is: SBO:0000252
is: B7Z7I0
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:8277

metaR AG13T8g
kinetic law: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_ab2f0add_5efc_4b8f_b700_94fd8b7edf5b
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5476
is: P10619
constant: false
type: Species
initial concentration: NaN
name: CTSA
boundary condition: true
initial amount: NaN

metaM crm hs g
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639
initial concentration: 1.0
is: SBO:0000247
type: Species
name: N-acylsphingosine
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false

metaM HC01118 r
type: Species
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: CHEBI:57310
is: SBO:0000247
name: presqualene diphosphate(3-)
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaR r2335
reversible: true
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM tymsf c
name: Tyramine O-sulfate
type: Species
boundary condition: false
is: HMDB06409
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247
constant: false
initial amount: NaN

metaR r1168
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
product: MODEL1310110047#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110047#
name: EC:2.3.1.26
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_ed71b348_fa01_47f6_8bfa_18ec2e82ed88
is: Q9NUD9
name: PIGV
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:55650
is: SBO:0000252
constant: false

metaR r1380
product: MODEL1310110047#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110047#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_2c5d2992_ed27_442d_8381_692d6a8544ec
constant: false
is encoded by: hsa:3420
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: IDH3B

http://identifiers.org/biomodels.db/MODEL1310110047#_f67b3933_1f49_4f6c_b387_bd510044899f
initial concentration: NaN
is encoded by: hsa:AL048840
constant: false
name: _AL048840_1_c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR FAOXC184x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_52bf9a4e_adb9_4787_be57_2a1e5681e243
initial concentration: NaN
name: PLCD4
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:84812
is: Q9BRC7
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_0cdcd1b5_32dd_4e99_bf17_d3d805b8a9f9
initial amount: NaN
is: B3KQH0
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: SLC35C1
boundary condition: true
is encoded by: hsa:55343

metaR ALASm
kinetic law: MODEL1310110047#
name: 5-aminolevulinate synthase
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.29
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.37
reversible: false
product: MODEL1310110047#
is described by: ECO:0000254

metaM c81crn c
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C15H27NO4 CHARGE: 0
initial concentration: 1.0
name: octenoyl carnitine
boundary condition: false
is: HMDB13324

http://identifiers.org/biomodels.db/MODEL1310110047#_c2a96b1a_50a6_4943_a2f1_c827a4ab57f7
is: E9KL44
initial amount: NaN
name: HADHA
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3030
initial concentration: NaN
constant: false

metaR KHK
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
name: ketohexokinase
modifier: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.3
fast: false
is: SBO:0000176
product: MODEL1310110047#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_476028a2_3109_4f5d_b831_d69ac3de9b35
constant: false
is encoded by: hsa:AU149534
has only substance units: false
name: _AU149534_1_m
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r2334
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185

metaR CITtam
name: citrate transport, mitochondrial
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000185
reversible: true
type: Reaction

metaR r1381
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110047#
reversible: true
fast: false
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaR PPItx
kinetic law: MODEL1310110047#
name: Diphosphate transporter, peroxisome
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185
product: MODEL1310110047#

metaR SUCCt2m
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110047#
is described by: ECO:0000269
fast: false
name: succinate transport, mitochondrial
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_f8cac81f_3e4b_4727_b94a_2ab92dc70fdc
is: SBO:0000252
initial amount: NaN
name: HGD
type: Species
is: Q93099
is encoded by: hsa:3081
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_7dc5832b_a2f3_4c8e_a1dc_bb20b0037212
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29926
name: GMPPA
boundary condition: true
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_d5729240_98c9_4488_bac2_651bc79e9c8c
initial amount: NaN
boundary condition: true
name: NNT
initial concentration: NaN
is encoded by: hsa:23530
is: Q13423
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR NAtx
type: Reaction
fast: false
is: SBO:0000185
reversible: true
name: sodium transport via diffusion (perioxisome)
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110047#

metaM so3 m
has only substance units: false
type: Species
is: HMDB00240
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
constant: false
is: CHEBI:17137
boundary condition: false
name: hydrogensulfite

metaM crm hs e
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:52639
name: N-acylsphingosine
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaR r2333
product: MODEL1310110047#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
fast: false

metaR THRCYSNaEx
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110047#
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110047#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_d26baa6d_6819_461e_95fd_6051f88db751
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: FH
type: Species
initial concentration: NaN
is: P07954
boundary condition: true
is encoded by: hsa:2271

http://identifiers.org/biomodels.db/MODEL1310110047#_a77775aa_9b18_4719_84af_4ae873c5a392
initial amount: NaN
type: Species
name: CPT2
constant: false
has only substance units: false
is: P23786
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1376
is: SBO:0000252

metaM tymsf e
has only substance units: false
name: Tyramine O-sulfate
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
is: HMDB06409
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaM HC02204 e
is: CHEBI:27624
initial amount: NaN
name: prostaglandin-b1
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false

metaR FAOXC2051843x
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110047#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#

metaM HC00229 e
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Isomaltose
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: CHEBI:28189

metaM Nacasp m
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: SBO:0000247
initial amount: NaN
is: CHEBI:16953
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00812
boundary condition: false
name: N-acetyl-L-aspartate(2-)

http://identifiers.org/biomodels.db/MODEL1310110047#_aaa2c091_e968_492e_8e52_40c760d62387
initial amount: NaN
is: P09923
has only substance units: false
type: Species
initial concentration: NaN
name: ALPI
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:248

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR FACOAL180i
kinetic law: MODEL1310110047#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
is: SBO:0000176
name: C180 fatty acid activation
product: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#

metaR B3GNT34g
reversible: false
fast: false
reactant: MODEL1310110047#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000176

metaM mi134p c
boundary condition: false
is: HMDB01143
initial concentration: 1.0
initial amount: NaN
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: CHEBI:58414
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
type: Species
constant: false

metaM pheme m
initial amount: NaN
initial concentration: 1.0
is: HMDB03178
type: Species
name: Protoheme
is: CHEBI:17627
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
constant: false
is: C00032
is: SBO:0000247
boundary condition: false

metaR RE3002X
is described by: ECO:0000000
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3002

metaM c81crn e
initial amount: NaN
notes: FORMULA: C15H27NO4 CHARGE: 0
has only substance units: false
is: HMDB13324
name: octenoyl carnitine
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_3175d6dd_3c48_443f_9d4c_2c00339866c8
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:549
name: AUH
is: Q13825
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r0437
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000000
product: MODEL1310110047#
fast: false
reversible: true
reactant: MODEL1310110047#

metaM s2l2fn2m2masn e
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: HMDB00244
is: C00255
name: PA6
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:3554

metaR r2332
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
type: Reaction
reversible: true
product: MODEL1310110047#

metaR r1167
fast: false
is: SBO:0000176
type: Reaction
name: EC:2.3.1.26
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_da48ae9e_f505_4fce_83c1_1b8605d95197
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: GUCY1B2
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2974
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_c81ec46f_8849_4115_88e9_581525080425
initial concentration: NaN
is encoded by: hsa:221823
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: PRPS1L1
initial amount: NaN
has only substance units: false

metaR S23T3g
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.6
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is described by: ECO:0000000
reversible: false
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

metaM dem2emgacpail prot hs r
boundary condition: false
is: HMDB06219
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: D00348
type: Species
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
is: http://identifiers.org/pubchem.compound/7847414
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_5e231233_f892_4c89_9fd3_311dc2147177
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q96C36
has only substance units: false
name: PYCR2
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:29920

http://identifiers.org/biomodels.db/MODEL1310110047#_43a4f274_2d7c_4b9f_b7af_5627f9b8e60b
initial amount: NaN
boundary condition: true
is encoded by: hsa:5152
initial concentration: NaN
type: Species
has only substance units: false
name: PDE9A
constant: false
is: SBO:0000252

metaM fald e
is: SBO:0000247
name: formaldehyde
boundary condition: false
constant: false
type: Species
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
is: CHEBI:16842
is: HMDB01426
initial amount: NaN
initial concentration: 1.0

metaR FAOXC14C12m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR ETF
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
name: electron transfer flavoprotein
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaM ile L e
initial amount: NaN
boundary condition: false
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
constant: false
name: L-isoleucine
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_0e303a61_2863_4c2b_ab65_8b02414f3780
type: Species
name: FDFT1
initial amount: NaN
is: P37268
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2222

metaR r0653
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
product: MODEL1310110047#
type: Reaction
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110047#

metaM nicrnt c
is: HMDB01132
constant: false
is: CHEBI:57502
is: SBO:0000247
initial concentration: 1.0
name: Nicotinate D-ribonucleotide
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
type: Species
is: C01185
has only substance units: false
initial amount: NaN
boundary condition: false

metaR r2338
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
product: MODEL1310110047#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110047#

metaR IDPtn
product: MODEL1310110047#
is: SBO:0000185
kinetic law: MODEL1310110047#
type: Reaction
name: IDP nuclear transport
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR S6TASE1ly
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110047#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR FUCASEe
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, extracellular
product: MODEL1310110047#
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176

metaR HYXNt
modifier: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Hypoxanthine transport
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is: SBO:0000185
reversible: true

metaR DNDPt40m
fast: false
name: dUTP transport via dADP antiport
modifier: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR FAOXC16C14m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaM hista e
initial concentration: 1.0
is: HMDB00870
has only substance units: false
is: SBO:0000247
is: CHEBI:58432
boundary condition: false
name: histamium
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial amount: NaN
type: Species

metaM hexc e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: HMDB02356
boundary condition: false
is: CHEBI:31013
initial amount: NaN
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
name: cerotate

metaR UDPDOLPT U
reactant: MODEL1310110047#
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.117
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
fast: false
product: MODEL1310110047#

metaM galgbside hs g
name: galactosylgloboside
type: Species
is: SBO:0000247
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:18259
constant: false
boundary condition: false

metaR RE0944E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
fast: false
name: RE0944
is: SBO:0000176
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_2391a7d9_543b_4e3e_85db_864a1669ac56
has only substance units: false
is: SBO:0000252
name: NDUFV1
initial concentration: NaN
is encoded by: hsa:4723
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: E5KNH5

metaR PPItr
fast: false
reversible: true
product: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110047#
name: Diphosphate transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110047#_92437eaf_39a8_4bb0_954c_ba47060434b2
initial concentration: NaN
is encoded by: hsa:23057
constant: false
has only substance units: false
initial amount: NaN
name: NMNAT2
is: SBO:0000252
boundary condition: true
type: Species

metaM od2coa c
initial concentration: 1.0
is: SBO:0000247
is: C16218
constant: false
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
is: HMDB06529
is: CHEBI:50570
has only substance units: false
name: trans-Octadec-2-enoyl-CoA
boundary condition: false
initial amount: NaN

metaM mal L m
is: CHEBI:15589
is: SBO:0000247
is: HMDB00156
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
has only substance units: false
boundary condition: false
type: Species

metaM cdp e
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
name: CDP(3-)
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01546

metaR CYOR u10m
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
name: ubiquinol-6 cytochrome c reductase, Complex III
modifier: MODEL1310110047#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000185
reversible: false
reactant: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_dd737a47_ec7c_46c0_b5ca_742f78f5605d
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:7001
boundary condition: true
name: PRDX2
is: P32119
constant: false
initial concentration: NaN

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR r0994
reversible: true
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#
name: Facilitated diffusion
reactant: MODEL1310110047#
fast: false

metaM man l
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
name: D-mannose
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16024

metaR GPIMTer U
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
is described by: ECO:0000000
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum

metaM ile L c
is: CHEBI:17191
constant: false
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
name: L-isoleucine
is: HMDB00172
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR DIGALSIDEtl
kinetic law: MODEL1310110047#
reversible: true
type: Reaction
reactant: MODEL1310110047#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110047#
name: digalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR DM atp c
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)
kinetic law: MODEL1310110047#

metaR ST8SIA12
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.8
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
product: MODEL1310110047#
reactant: MODEL1310110047#
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110047#
type: Reaction

metaR r0651
product: MODEL1310110047#
reversible: true
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_d183081e_6ea8_4a0a_b402_a4df42016b62
name: ACLY
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:47
has only substance units: false
constant: false

metaM ksii core4 deg2 l
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: CHEBI:12936
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB00143
name: keratan sulfate II (core 4-linked), degradation product 2

metaM dd3coa x
boundary condition: false
constant: false
name: 3-dodecenoylcoa
is: HMDB04257
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM dlnlcgcrn m
is: HMDB01311
initial concentration: 1.0
is: CHEBI:16004
initial amount: NaN
boundary condition: false
name: dihomo-gamma-linolenyl carnitine
is: SBO:0000247
constant: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
type: Species
has only substance units: false

metaR PRISTtx
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
name: prist peroxisomal transport
reactant: MODEL1310110047#
type: Reaction
fast: false
reversible: true
is: SBO:0000185

metaM leuktrC4 c
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
has only substance units: false
type: Species
name: leukotriene C4(2-)
boundary condition: false
is: CHEBI:57973
is: HMDB01198

metaR RBK
is: SBO:0000176
is described by: ECO:0000304
reversible: false
fast: false
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
name: ribokinase
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.1.15
product: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

metaR FAOXC2051843m
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
is described by: ECO:0000000
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#

metaM s2l2n2m2masn l
initial concentration: 1.0
constant: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: CHEBI:18287
is: HMDB00174
name: de-Fuc form of PA6
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaM oxa c
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
has only substance units: false
initial concentration: 1.0
is: CHEBI:30623
name: oxalate(2-)

metaR AG13T9g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110047#
fast: false
reversible: false

metaM homoval m
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00118
initial concentration: 1.0
initial amount: NaN
name: Homovanillate
type: Species
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: CHEBI:545959
has only substance units: false

metaR r0995
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_e8c09041_669b_4e22_9854_0e5873b9ab43
initial concentration: NaN
has only substance units: false
is: SBO:0000297
has part: Q9UN42
has part: P50993
type: Species
is encoded by: hsa:477
name: ATP1B4:ATP1A2
is encoded by: hsa:23439
initial amount: NaN
constant: false
boundary condition: true

metaM hista c
is: HMDB00870
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: histamium
has only substance units: false
is: CHEBI:58432

metaM hexc c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
has only substance units: false
name: cerotate
is: HMDB02356
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:31013
constant: false

metaR r0652
is: SBO:0000176
type: Reaction
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
fast: false
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
kinetic law: MODEL1310110047#

metaR ST8SIA11
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.8
modifier: MODEL1310110047#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
name: Beta-galactoside alpha-2,3-sialyltransferase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ

metaM ha l
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
type: Species
is: CHEBI:16336
name: hyaluronan
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaM lgnc e
constant: false
is: HMDB02003
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: CHEBI:31014
has only substance units: false
name: lignocerate

metaM ksi pre2 g
constant: false
is: CHEBI:58053
type: Species
is: SBO:0000247
is: HMDB00175
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 2
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial amount: NaN

metaR S6T18g
is described by: ECO:0000000
reversible: false
product: MODEL1310110047#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_b6f1a95f_b253_4657_9d24_5b1ce25c7e59
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:6184
constant: false
initial amount: NaN
is: P04843
initial concentration: NaN
name: RPN1

metaR 3HBCOARc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (R)-3-hydroxybutanoyl-CoA into cytosol
type: Reaction

metaR RE2659R
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
name: RE2659
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_5818a886_40d8_4238_8fd0_ce1bd0fac26b
is: SBO:0000252
is: P54819
boundary condition: true
type: Species
is encoded by: hsa:204
name: AK2
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_cc3dfb15_b846_4bf4_87a3_62a969acba2e
is: O00746
initial amount: NaN
has only substance units: false
name: NME4
is encoded by: hsa:4833
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_e264c43f_db22_4687_801a_a4e02dcd6aed
constant: false
is: SBO:0000252
is encoded by: hsa:29925
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: GMPPB

metaR LPS3e
is described by: ECO:0000000
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
fast: false
reactant: MODEL1310110047#
reversible: false
name: lipase, extracellular
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000176

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM tetpent3coa c
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
boundary condition: false
is: C16167
constant: false
initial concentration: 1.0
initial amount: NaN
name: tetracosapentaenoyl coenzyme A, n-3
type: Species
is: SBO:0000247

metaM aicar c
constant: false
initial amount: NaN
is: C04677
is: HMDB01517
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
boundary condition: false
initial concentration: 1.0
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475

metaM forglu c
name: N-Formimidoyl-L-glutamate
is: HMDB00854
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: SBO:0000247
is: C00439
is: CHEBI:18327
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_0a5a8859_e939_40ec_b783_94928fb178dc
is encoded by: hsa:D29675
boundary condition: true
name: _D29675_1_c
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_7fefd5ff_60bc_48ff_bfce_846eee8cf04e
has only substance units: false
type: Species
name: PANK4
initial amount: NaN
is: SBO:0000252
is: Q9NVE7
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55229

metaR APOCFm
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is: SBO:0000176
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
name: Apocarboxylase formation, mitochondrial
fast: false
type: Reaction
reversible: false

metaR KHte
fast: false
product: MODEL1310110047#
is: SBO:0000185
name: KHte
is described by: ECO:0000134
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

metaM man e
constant: false
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
initial amount: NaN
has only substance units: false
is: HMDB00169
name: D-Mannose
is: C00159
is: SBO:0000247
initial concentration: 1.0

metaR DM 13 cis retn n
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-retinoate demand
type: Reaction

metaM ru5p D r
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58121
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: D-ribulose 5-phosphate(2-)

metaM biocyt m
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: HMDB03134
has only substance units: false
is: C05552
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_b96ef06e_dbb8_4691_8e35_20ae6712cf0f
is: SBO:0000252
name: UGDH
is encoded by: hsa:7358
boundary condition: true
is: O60701
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

metaM drib c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
name: 2-deoxy-D-ribose
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:28816
is: HMDB03224
has only substance units: false

metaR r0655
is: SBO:0000176
modifier: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reversible: true
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110047#
fast: false
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
type: Reaction

metaR M16NTg
reversible: false
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.143
modifier: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
reactant: MODEL1310110047#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110047#
fast: false
type: Reaction
is: SBO:0000176

metaR HSAT3ly
fast: false
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110047#
reversible: false

metaR CHOLESTle
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.13
product: MODEL1310110047#
is: SBO:0000176
name: hydrolysis of cholesterol ester by cholesterol esterase
fast: false
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR CO2tm
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reversible: true
name: CO2 transport (diffusion), mitochondrial
is: SBO:0000185

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR r0990
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#

metaM ksi pre15 g
is: CHEBI:58053
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 15
initial concentration: 1.0
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
constant: false
is: C00130
boundary condition: false
is: HMDB00175

metaR EHGLATm
modifier: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110047#
is described by: ECO:0000212
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_0a4169c3_b6bc_4128_affd_da68b2b2eb02
name: PLA2G2A
initial amount: NaN
is: P14555
constant: false
has only substance units: false
is encoded by: hsa:5320
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaM ocdcea r
type: Species
is: CHEBI:0
is: HMDB00207
name: octadecenoate (n-C18:1)
boundary condition: false
initial amount: NaN
is: C00712
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_4d8be022_3e25_429c_a4c1_bd48621b37af
name: _AV713053_1_m
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AV713053
initial amount: NaN
initial concentration: NaN

metaR FAOXC184C163m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaM aicar e
initial amount: NaN
is: HMDB01517
is: CHEBI:58475
has only substance units: false
is: C04677
boundary condition: false
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_58253a8f_5e7e_4c16_bb02_a218ee33574d
initial amount: NaN
is encoded by: hsa:2531
name: KDSR
type: Species
initial concentration: NaN
is: Q06136
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR DM gpi sig er
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR H8TAer
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
name: H8 transamidase, endoplasmic reticulum
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
product: MODEL1310110047#

metaM man g
initial concentration: 1.0
is: SBO:0000247
name: D-mannose
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
type: Species
boundary condition: false
is: CHEBI:16024

metaR HPACtr
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
name: hydroxyphenylacetate transport via diffusion
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_c610618f_d267_492a_9760_67362487eb88
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1178
is: C5HZ13
initial amount: NaN
name: CLC
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaM biocyt n
name: Biocytin
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: C05552
constant: false
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886

metaM cs e deg1 l
type: Species
boundary condition: false
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
is: CHEBI:57737
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
constant: false
initial amount: NaN
is: HMDB00868
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_db194d2f_de43_48dd_b813_f12eab23eb33
boundary condition: true
initial amount: NaN
is encoded by: hsa:1339
constant: false
initial concentration: NaN
name: COX6A2
has only substance units: false
is: Q02221
type: Species
is: SBO:0000252

metaR GAPD
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
fast: false
name: glyceraldehyde-3-phosphate dehydrogenase
modifier: MODEL1310110047#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.12
is described by: ECO:0000134

metaR ADK3m
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.10
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
name: adentylate kinase (GTP)
reactant: MODEL1310110047#

metaR PEPCK
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.1.1.32
modifier: MODEL1310110047#
reversible: false
name: Phosphoenolpyruvate carboxykinase (GTP)
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (5105.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:17211624,PMID:17888579,PMID:17888580,PMID:8325643 NOTES:17888579 - kinetic characterization of human cytosolic form; 8325643 - homology to rat; 17211624 - immunohistochemistry for expression
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110047#

metaM ump e
is: CHEBI:57865
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00288
has only substance units: false
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR LNLNCACRNt
modifier: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_a075eac4_063a_4176_9508_3ea8ff22a5db
constant: false
initial amount: NaN
name: PLCZ1
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:89869
is: Q86YW0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_12191f95_2c10_444c_9624_31deb6973214
boundary condition: true
constant: false
name: BPNT1
is: O95861
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10380
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_aaf91408_df72_4792_b620_afbea39731fb
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:29925
is: Q9Y5P6
has only substance units: false
name: GMPPB

metaR FAOXC185m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM hxcoa c
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
is: HMDB13130
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: Hexanoyl-CoA (n-C6:0CoA)
is: SBO:0000247

metaR RE1810M
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
fast: false
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
name: RE1810
is described by: ECO:0000000
reversible: true

metaR CO2tp
name: CO2 peroxisomal transport
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_f4772bba_fc36_416b_9a05_92fe0a8e62e8
constant: false
is encoded by: hsa:4540
is: P03915
name: ND5
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR 5HOXINDACTO2OX
is: SBO:0000176
kinetic law: MODEL1310110047#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
type: Reaction
modifier: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.3.1
reactant: MODEL1310110047#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f0a7a72e_827b_4c82_a9ba_8beac1fe1a3e
has only substance units: false
is: SBO:0000252
constant: false
is: O60503
type: Species
name: ADCY9
boundary condition: true
is encoded by: hsa:115
initial amount: NaN
initial concentration: NaN

metaM ksi deg35 l
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:12936
name: keratan sulfate I, degradation product 35
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
has only substance units: false
initial concentration: 1.0
is: HMDB00143
constant: false

metaM lnlccoa c
boundary condition: false
is: HMDB01064
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_891a863d_a589_48c1_ae98_c9479022ee05
name: TKT
is: E7EPA7
is encoded by: hsa:7086
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_68d122e8_54f9_4c7e_bcb4_dc07ec8b6d99
is encoded by: hsa:10993
name: SDS
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: P20132

metaR RE0827E
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
name: RE0827
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22

http://identifiers.org/biomodels.db/MODEL1310110047#_5e9f83ac_9196_445e_989d_3e80e0c43ac4
constant: false
is: SBO:0000252
type: Species
name: B3GNT8
initial concentration: NaN
is encoded by: hsa:374907
is: Q7Z7M8
initial amount: NaN
boundary condition: true
has only substance units: false

metaM man r
constant: false
initial amount: NaN
name: D-mannose
type: Species
is: CHEBI:16024
is: HMDB00169
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

http://identifiers.org/biomodels.db/MODEL1310110047#_ac1a37d5_602c_495a_bbed_8b9b3f8710e8
initial amount: NaN
name: PRPS2
is: P11908
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5634
initial concentration: NaN

metaM 3ddecdicoa x
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
name: 3,6-dodecadienoylcoa
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB03952
type: Species
is: C05280

metaM HC01496 m
is: CHEBI:28095
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
name: 2-Amino-3-oxoadipate

metaR S3TASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110047#

metaR r0881
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
reversible: false
name: Active transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
fast: false
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_71cc0689_0362_411f_b9f1_4462b93252e4
is encoded by: hsa:491
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: Q4J699
type: Species
name: ATP2B2
has only substance units: false

metaR FAOXC225C204x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaR PPItm
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
fast: false
name: diphopshate transporter, mitochondrial
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
reversible: true
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR LINKDEG2ly
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110047#
name: degradation of proteoglycan linkage region, lysosomal

metaM ump c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00105
constant: false
initial amount: NaN
is: CHEBI:57865
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
boundary condition: false
name: UMP

metaM pcrn c
is: HMDB00824
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
name: propionyl-carnitine
constant: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/107738
initial amount: NaN
has only substance units: false

metaR ALADGLNexR
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: L-alanine/glutamine reversible exchange
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reactant: MODEL1310110047#

metaM ha e
constant: false
name: hyaluronan
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16336
is: SBO:0000247
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_84de51d3_bdb1_4244_bf78_fcc3b0e74bed
is encoded by: hsa:113451
name: ADC
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q96A70
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM lgnc c
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB02003
has only substance units: false
initial amount: NaN
name: lignocerate
constant: false

metaM 3bcrn c
is: HMDB04047
notes: FORMULA: C11H21NO5 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: C14143
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: 3-hydroxy butyryl carnitine

metaR RE1518M
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
product: MODEL1310110047#
modifier: MODEL1310110047#
name: RE1518
reversible: true

metaR RE3003M
name: RE3003
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110047#

metaM pre prot r
is: HMDB03125
constant: false
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species
has only substance units: false
notes: FORMULA: XY CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16240
initial amount: NaN

metaM acgam6p c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
name: N-acetyl-D-glucosamine 6-phosphate(2-)
type: Species
is: CHEBI:57513
boundary condition: false
constant: false
has only substance units: false
is: HMDB01062
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM leuktrE4 c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: leukotriene E4(1-)
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
is: HMDB02200
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_1595927b_c4be_4c70_8eda_10412b04deb5
name: SDHA
initial amount: NaN
is: P31040
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:6389

metaM tetd7ecoa m
type: Species
is: SBO:0000247
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: HMDB13109
constant: false
initial amount: NaN
name: 7-tetradecenoylcoa
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM xyl D c
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
initial amount: NaN
is: CHEBI:15936
initial concentration: 1.0
name: aldehydo-D-xylose
type: Species

metaR ACOX2x
is version of: http://identifiers.org/ec-code/1.17.99.3
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 NJ
modifier: MODEL1310110047#
is: SBO:0000176
name: acyl-Coenzyme A oxidase 2, branched chain
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110047#
reversible: false
product: MODEL1310110047#

metaM hs deg10 l
initial amount: NaN
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
is: HMDB00127
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15748
name: heparan sulfate, degradation product 10
type: Species
constant: false
has only substance units: false
boundary condition: false

metaR C81CRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_1839e41f_a083_4ed5_b86f_a92e7b3b6e74
name: B3GALNT1
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O75752
type: Species
is encoded by: hsa:8706
constant: false
has only substance units: false

metaR XOL27OHtm
product: MODEL1310110047#
name: 27 hydroxy cholesterol transport
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_2bbed0b6_ccb4_4c21_a1e7_05728aed4b64
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: DHFR
is: SBO:0000252
initial concentration: NaN
is: P00374
is encoded by: hsa:1719
has only substance units: false

metaM g2m8masn r
constant: false
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
has only substance units: false
is: C05874
boundary condition: false
type: Species
notes: FORMULA: C82H137N2O65X CHARGE: 0
initial amount: NaN

metaM cdp c
name: CDP
is: HMDB01546
is: C00112
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:58069
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
constant: false

metaM estradiol e
is: SBO:0000247
name: estradiol
boundary condition: false
initial amount: NaN
is: HMDB00151
has only substance units: false
constant: false
type: Species
is: CHEBI:16469
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial concentration: 1.0

metaM 3tetd7ecoacrn c
has only substance units: false
is: HMDB02014
initial concentration: 1.0
name: 3-hydroxy tetradecenoyl-7-carnitine
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C21H39NO5 CHARGE: 0
initial amount: NaN
boundary condition: false

metaR LNELDCt
is: SBO:0000185
reactant: MODEL1310110047#
name: fatty acid transport via diffusion
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_bb855f75_2de0_441e_8f73_ea6cc9816544
has only substance units: false
constant: false
is: P82251
is: SBO:0000252
initial concentration: NaN
type: Species
name: SLC7A9
boundary condition: true
initial amount: NaN
is encoded by: hsa:11136

http://identifiers.org/biomodels.db/MODEL1310110047#_0083b656_e4e7_4e28_aaec_e676a5e8fa62
is: Q9HCR9
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: PDE11A
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:50940

metaM mal L x
is: HMDB00156
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: (S)-malate(2-)
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaM 3bcrn e
is: SBO:0000247
name: 3-hydroxy butyryl carnitine
constant: false
has only substance units: false
is: HMDB04047
notes: FORMULA: C11H21NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: C14143
type: Species
boundary condition: false

metaR r0650
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
reversible: true
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
is described by: ECO:0000000
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.36

metaM oxa e
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:30623
initial concentration: 1.0
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
is: HMDB02329
initial amount: NaN

metaM camp c
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3',5'-cyclic AMP(1-)
is: CHEBI:58165
has only substance units: false
is: HMDB00058

http://identifiers.org/biomodels.db/MODEL1310110047#_b21ea5ab_6d08_49ab_9413_41280363f329
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3612
type: Species
boundary condition: true
name: IMPA1
constant: false
initial amount: NaN
initial concentration: NaN
is: B7Z6Q4

http://identifiers.org/biomodels.db/MODEL1310110047#_dff9469e_ea59_4ec6_86d7_77934b8deb41
initial amount: NaN
is encoded by: hsa:C7orf24
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: _C7orf24_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_67df3985_35b7_4597_b8ac_75ddb40e6738
is: Q02318
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:1593
name: CYP27A1

metaR ABO7g
is: SBO:0000176
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
type: Reaction
fast: false
reactant: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
product: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.37

metaM aprgstrn e
is: HMDB03069
type: Species
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
has only substance units: false
constant: false
name: (20S)-20-hydroxypregn-4-en-3-one
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:28453

metaM leuktrC4 e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01198
name: leukotriene C4(2-)
is: CHEBI:57973

metaR MI134PP
is: SBO:0000176
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
name: inositol-1,3,4-trisphosphate 1-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.57
is described by: ECO:0000269
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
type: Reaction
modifier: MODEL1310110047#

metaM 4nph e
has only substance units: false
initial concentration: 1.0
name: 4-nitrophenolate
is: CHEBI:57917
type: Species
initial amount: NaN
is: HMDB01232
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870

metaR r1914
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
fast: false

metaM estradiol c
boundary condition: false
is: HMDB00151
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
name: estradiol
is: CHEBI:16469
has only substance units: false

metaM btcoa x
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
is: C00136
constant: false
is: HMDB01088
name: Butanoyl-CoA
initial amount: NaN
has only substance units: false

metaM succ c
name: Succinate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30031
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
is: C00042
is: HMDB00254

metaM fuc12gal14acglcgalgluside hs g
name: Type IIH glycolipid
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00304
type: Species
is: CHEBI:57847
initial concentration: 1.0

metaR r0885
reactant: MODEL1310110047#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_f5695513_cc7b_4c3d_8c74_32f8796160ca
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:27124
name: INPP5J
has only substance units: false
constant: false

metaR SO4HCOtex
reversible: false
is described by: ECO:0000304
product: MODEL1310110047#
name: sulfate transport via bicarbonate countertransport
is: SBO:0000185
reactant: MODEL1310110047#
fast: false
type: Reaction
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

metaR THRGLNexR
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000304
reactant: MODEL1310110047#
reversible: true
type: Reaction
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#

metaM fald c
is: SBO:0000247
is: HMDB01426
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
is: CHEBI:16842
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: formaldehyde

metaM 3tetd7ecoacrn e
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB02014
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C21H39NO5 CHARGE: 0
name: 3-hydroxy tetradecenoyl-7-carnitine

http://identifiers.org/biomodels.db/MODEL1310110047#_1e497e74_fb23_4061_b03a_f081916f387a
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q8TD30
name: GPT2
boundary condition: true
is encoded by: hsa:84706
type: Species

metaM biocyt e
boundary condition: false
has only substance units: false
is: C05552
is: HMDB03134
name: Biocytin
initial concentration: 1.0
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_48bfaf2d_4aed_40f5_9485_b34bfe445c1d
initial concentration: NaN
name: ACAT2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:39
is: Q9BWD1
constant: false
has only substance units: false
type: Species
boundary condition: true

metaM m5masnB2 g
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C52H87N2O40X CHARGE: 0
boundary condition: false
constant: false
is: HMDB06814
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
is: CHEBI:58401
has only substance units: false

metaR GluForTx
product: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
modifier: MODEL1310110047#
name: Glutamate formimidoyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110047#

metaR FAOXC143C123m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR FACOAL191
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
name: fatty-acid--CoA ligase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110047#_f36e4647_9b7e_4723_936a_4902e1d8e899
is: Q5JT09
type: Species
is encoded by: hsa:83549
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: UCK1

http://identifiers.org/biomodels.db/MODEL1310110047#_1e64b34e_6f4a_47ba_93ff_c907e1f6b270
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: _AI285872_1_c
boundary condition: true
is encoded by: hsa:AI285872

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR r0539
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
modifier: MODEL1310110047#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
product: MODEL1310110047#
reversible: true

metaR r1916
modifier: MODEL1310110047#
reversible: false
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
is: SBO:0000185
fast: false

metaM aprgstrn c
is: CHEBI:28453
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
is: HMDB03069
type: Species
has only substance units: false
initial amount: NaN
name: (20S)-20-hydroxypregn-4-en-3-one
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_01cecf8d_3051_4c14_832c_c99b31d2d2f5
boundary condition: true
name: AMACR
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: Q9UHK6
is encoded by: hsa:23600
is: SBO:0000252

metaM ksi deg17 l
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 17
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110047#_d8fd0cf9_b8bd_4bb6_b9f4_e97418569ed2
constant: false
name: B3GALT5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10317
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR r0559
is described by: ECO:0000000
is: SBO:0000176
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
type: Reaction
modifier: MODEL1310110047#

metaR PROSTGD2t
fast: false
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
is: SBO:0000185
product: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000269

metaM 4nph c
is: SBO:0000247
name: 4-nitrophenolate
initial amount: NaN
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
is: CHEBI:57917
constant: false
is: HMDB01232
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_72d9f3c8_cb4c_4dbf_aeca_f390f13343e5
is: Q9NNW7
constant: false
name: TXNRD2
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:10587
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_129ba097_2747_441b_a9eb_a03622257ea3
initial amount: NaN
is: O43272
type: Species
boundary condition: true
is encoded by: hsa:5625
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: PRODH

http://identifiers.org/biomodels.db/MODEL1310110047#_fb12336f_a2a3_49fc_9a90_2b7896c81494
name: HMGCS2
is: P54868
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3158
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM gam6p c
constant: false
is: HMDB01254
initial amount: NaN
is: CHEBI:12962
type: Species
name: D-Glucosamine 6-phosphate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: SBO:0000247
boundary condition: false

metaM dhap m
name: Dihydroxyacetone phosphate
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01473
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
is: C00111

metaM 3ddecdicoa m
constant: false
is: HMDB03952
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: C05280
initial concentration: 1.0
name: 3,6-dodecadienoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_39a32a47_b764_4b6c_9ec5_2e54a76dd877
type: Species
is encoded by: hsa:23305
name: ACSL6
constant: false
initial amount: NaN
is: SBO:0000252
is: B2RB13
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR DHAPtc
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of DHAP into cytosol
is described by: ECO:0000134
fast: false
is: SBO:0000185
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#

metaR CMPACNAtn
fast: false
reactant: MODEL1310110047#
reversible: false
type: Reaction
product: MODEL1310110047#
name: CMP-Sia nuclear export
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM em2emgacpail hs r
has only substance units: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB03125
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:16240

http://identifiers.org/biomodels.db/MODEL1310110047#_b3ed8eaa_5abe_4c36_ac99_42c34ab5b71e
is: SBO:0000297
constant: false
name: ATP1A3:ATP1B2
initial concentration: NaN
has only substance units: false
boundary condition: true
has part: P14415
initial amount: NaN
is encoded by: hsa:482
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_d3fc6a3b_fd46_49c9_8211_af0916f1e27a
name: TPI1
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q53HE2
constant: false
is encoded by: hsa:7167
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_f31e54ae_6b1e_44a8_abd3_04d641f4f858
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:80864
name: EGFL8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q99944
type: Species

metaR r0558
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110047#
reversible: true
type: Reaction
fast: false
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
modifier: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_94d5ddbf_7b61_4f3a_97c6_dd0df5a295d7
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3658
initial concentration: NaN
name: IREB2
is: SBO:0000252
boundary condition: true
type: Species
is: P48200

metaR AKGt4 3
name: AKG transport via sodium symport
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (64849.1) or (64849.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10099705,PMID:10794676 NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110047#

metaM HC01610 e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: CoproporphyrinogenI
constant: false
is: CHEBI:28607
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
type: Species
boundary condition: false

metaR EX c16dc
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_755372e8_adc2_4943_aa0c_eb617e831505
has only substance units: false
is encoded by: hsa:4695
is: SBO:0000252
is: O43678
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NDUFA2
constant: false

metaR CYTK14n
product: MODEL1310110047#
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110047#
modifier: MODEL1310110047#

metaM but c
has only substance units: false
initial amount: NaN
name: butyrate
is: HMDB00039
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: SBO:0000247
is: CHEBI:17968
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

metaM cytd c
has only substance units: false
initial concentration: 1.0
is: C00475
initial amount: NaN
is: SBO:0000247
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
name: Cytidine
type: Species
is: HMDB00089
constant: false

metaR DOLDPP Uer
reversible: false
modifier: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.6.1.43
type: Reaction
fast: false
product: MODEL1310110047#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
is: SBO:0000176
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaM ppa m
name: propionate
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
is: CHEBI:17272
has only substance units: false
is: HMDB00237
constant: false

metaM 3snpyr m
is: CHEBI:1665
initial amount: NaN
name: 3-Sulfinopyruvate
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02332
has only substance units: false
type: Species
constant: false

metaR PETOHMm hs
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: phosphatidylethanolamine N-methyltransferase
reactant: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.17
fast: false
is described by: ECO:0000254

metaM ksi pre30 g
type: Species
constant: false
is: HMDB00175
boundary condition: false
is: C00130
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
is: SBO:0000247
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
name: keratan sulfate I biosynthesis, precursor 30

metaM cspg a l
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:36005
has only substance units: false
is: SBO:0000247
is: HMDB02183
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan

metaR SPMS
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
kinetic law: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.16
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#
name: spermidine synthase
type: Reaction

metaM tetpent3 c
is: HMDB06323
type: Species
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: tetracosapentaenoic acid, n-3

metaR SPHK21c
modifier: MODEL1310110047#
name: sphingosine kinase 2
is described by: ECO:0000269
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.1.91
type: Reaction
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110047#_3a68f1cc_6661_47c3_b5cf_ced5b65ab4ae
name: GALNT9
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:50614
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: Q9HCQ5

metaM 3hdeccoa c
initial concentration: 1.0
boundary condition: false
name: 3-hydroxyhexadecenoylcoa
is: HMDB02014
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
constant: false

metaR PGCD
kinetic law: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
name: phosphoglycerate dehydrogenase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.95
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#

metaR DOLP Uter
reactant: MODEL1310110047#
reversible: false
product: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol phosphate flippase (uterus)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_74436270_793b_4345_b496_b432cb1ee819
is encoded by: hsa:2877
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: GPX2
initial amount: NaN
constant: false
is: P18283

http://identifiers.org/biomodels.db/MODEL1310110047#_92a5a92d_6796_46d8_a978_a031b86768c2
initial amount: NaN
type: Species
name: ITPA
constant: false
is: SBO:0000252
is: Q9BY32
boundary condition: true
is encoded by: hsa:3704
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_e00ec6df_4089_4484_bead_1829b5737384
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:65010
is: SBO:0000252
type: Species
boundary condition: true
name: SLC26A6
is: Q9NQU1
initial amount: NaN

metaR DOLASNT Uer
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
type: Reaction
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
fast: false
is described by: ECO:0000000
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.119
is: SBO:0000176
modifier: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaR r0226
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
kinetic law: MODEL1310110047#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
type: Reaction

metaM CE1944 c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:36781
name: 1-pyrrolinium
constant: false
initial amount: NaN

metaR LACZe
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.108
reactant: MODEL1310110047#
reversible: false
is: SBO:0000176
modifier: MODEL1310110047#
name: b-galactosidase, extracellular
type: Reaction
is described by: ECO:0000134
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase

http://identifiers.org/biomodels.db/MODEL1310110047#_ac31c022_c15d_4daa_b654_16036cdf1012
initial concentration: NaN
constant: false
initial amount: NaN
name: FLAD1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80308
has only substance units: false
type: Species

metaR SUCCOAPET
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR r1177
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
name: EC:3.1.1.13
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_bdc49098_2fee_4162_85f5_030e992e81cd
name: PRDX1
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5052
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_9a1e7c4b_f3bc_400d_abab_992a8fc85073
name: PANK2
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q9BZ23
constant: false
type: Species
is encoded by: hsa:80025

metaR B3GNT12g
is described by: ECO:0000269
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110047#
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is: SBO:0000176
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_3526ed95_c293_4e7f_9b63_fbab3269b4c9
name: ANPEP
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: Q59E93
initial concentration: NaN
is encoded by: hsa:290
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_417e3eb9_ab71_4699_a52d_1b1ee6bd2333
is: SBO:0000252
is encoded by: hsa:205
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: AK4
type: Species

metaM ksi deg6 l
name: keratan sulfate I, degradation product 6
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB00143
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110047#_96076ca2_c076_462d_881d_6729d5a46746
initial concentration: NaN
is: F5GY65
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8402
boundary condition: true
constant: false
name: SLC25A11

metaM cpppg3 c
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
is: C03263
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Coproporphyrinogen III
is: CHEBI:57309
is: HMDB01261
initial amount: NaN

metaM hdca l
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
constant: false
initial concentration: 1.0
is: CHEBI:7896
is: HMDB00220
type: Species
has only substance units: false
is: SBO:0000247
name: palmitate
initial amount: NaN

metaR RE3001M
name: RE3001
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.34
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#

metaM tetpent3 e
name: tetracosapentaenoic acid, n-3
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB06323
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_95fc1e11_a05e_4af0_920e_7c638dad580f
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57419
name: SLC24A3
initial concentration: NaN
has only substance units: false
type: Species
is: Q9HC58

metaM HC01180 c
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
boundary condition: false
name: D-tagatofuranose 1,6-bisphosphate(4-)
constant: false
type: Species
is: CHEBI:58694
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_1a9e4cc3_d995_4586_889d_1d69aee11ceb
boundary condition: true
name: HMGCS2
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:3158
is: P54868
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_07d4e606_abdb_4fd4_8dcd_ec998ec1b08e
is encoded by: hsa:5152
type: Species
is: SBO:0000252
has only substance units: false
name: PDE9A
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR LGNCt
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110047#_b8ec5897_a900_4103_8a91_1436004bc4ed
initial concentration: NaN
name: MTHFD1L
is: B2RD24
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:25902

metaR NOt
product: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
reactant: MODEL1310110047#
name: NO transport (diffusion)
is: SBO:0000185

metaM gly c
is: CHEBI:3339
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0
is: C00037
is: SBO:0000247
name: Glycine
initial concentration: 1.0
constant: false
is: HMDB00123
boundary condition: false

metaM dgtp c
is: C00286
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16497
initial concentration: 1.0
name: dGTP
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR C4STMO1r
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false
product: MODEL1310110047#
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.72
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
modifier: MODEL1310110047#

metaR Coqe
fast: false
product: MODEL1310110047#
is described by: ECO:0000134
reactant: MODEL1310110047#
reversible: true
name: Transport of q10
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110047#
is: SBO:0000185

metaR AICART
fast: false
is: SBO:0000176
reversible: true
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.3
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is described by: ECO:0000269

metaM dlnlcg e
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: SBO:0000247
type: Species
constant: false
name: dihomo-gamma-linolenic acid (n-6)
is: HMDB02925
initial amount: NaN
is: CHEBI:53486

metaM amet r
name: S-adenosyl-L-methionine
is: CHEBI:15414
initial concentration: 1.0
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
boundary condition: false
is: HMDB01185
is: SBO:0000247
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f5f0b355_bf21_4f41_9dfa_c925d3d7539d
name: PDE5A
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: G5E9C5
boundary condition: true
is encoded by: hsa:8654
initial amount: NaN
initial concentration: NaN

metaR FAOXC15C13m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR G14T12g
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110047#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110047#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM mthgxl e
initial concentration: 1.0
constant: false
name: methylglyoxal
is: CHEBI:17158
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
type: Species
is: HMDB01167

metaR NDP8
product: MODEL1310110047#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
name: nucleoside-diphosphatase (dUDP)
modifier: MODEL1310110047#
is: SBO:0000176

metaM HC02203 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: prostaglandin-a2
is: CHEBI:27820
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_b777a104_fad0_40e1_8612_88b82db691af
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: PDE5A
initial amount: NaN
is encoded by: hsa:8654
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_f952ea2f_8461_424b_b91b_bf51a2ee40d0
initial concentration: NaN
type: Species
is encoded by: hsa:5152
initial amount: NaN
boundary condition: true
has only substance units: false
name: PDE9A
is: SBO:0000252
constant: false

metaM xoldiolone c
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: CHEBI:28477
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02197
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false

metaM 2dodtricoa m
boundary condition: false
is: C05279
name: 2,6,9-dodecatrienoylcoa
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: HMDB11123
has only substance units: false
type: Species
is: SBO:0000247

metaM hs deg1 l
is: SBO:0000247
initial amount: NaN
name: heparan sulfate, degradation product 1
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:17180
has only substance units: false
boundary condition: false
is: HMDB01352

metaM dgtp e
name: dGTP
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
has only substance units: false
is: HMDB01440
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0

metaR C142CPT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaM CE1926 e
initial concentration: 1.0
is: HMDB00127
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: SBO:0000247
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110047#_3c146383_ad08_4951_a83a_dfe381edf151
initial concentration: NaN
is encoded by: hsa:5139
initial amount: NaN
has only substance units: false
constant: false
name: PDE3A
is: Q14432
is: SBO:0000252
boundary condition: true
type: Species

metaR r1722
is described by: ECO:0000000
modifier: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
fast: false
type: Reaction
product: MODEL1310110047#
reversible: false
name: Y+LAT2 Utilized transport

metaR CO2t
reversible: true
is: SBO:0000185
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
kinetic law: MODEL1310110047#
name: CO2 transporter via diffusion
fast: false
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_aaf61f2d_2972_4d52_8084_6543dbfeb05b
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:5295
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: B3KT19
name: PIK3R1

metaM T antigen g
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:22783
name: T antigen (core 1)
is: SBO:0000247
notes: FORMULA: C14H24NO10X CHARGE: 0
constant: false

metaM dlnlcgcrn c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial amount: NaN
type: Species
name: dihomo-gamma-linolenyl carnitine
is: CHEBI:16004
boundary condition: false
constant: false
is: HMDB01311
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_6878625b_7930_47e5_a502_4e068a6befb4
is: Q53TV9
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: RPE
has only substance units: false
is encoded by: hsa:6120

metaM gly e
constant: false
initial amount: NaN
is: C00037
name: Glycine
boundary condition: false
is: HMDB00123
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0

metaR FAOXC225C204m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR RE2426C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
type: Reaction
name: RE2426
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_ad35c9f3_ddac_4e5a_baf0_8abf63fe98a9
name: ITPKA
is: P23677
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3706

metaM HC02203 e
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:27820
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
has only substance units: false

metaR r0556
kinetic law: MODEL1310110047#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
product: MODEL1310110047#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is version of: http://identifiers.org/ec-code/1.14.19.1

metaR FUT14g
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
fast: false
reversible: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Galactoside 2-alpha-L-fucosyltransferase 1
reactant: MODEL1310110047#
is described by: ECO:0000269
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.69

metaR S6T7g
reversible: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR LEUtec
name: L-leucine transport via diffusion (extracellular to cytosol)
reversible: true
modifier: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110047#

metaR UREAtm
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000304
kinetic law: MODEL1310110047#
reversible: true
name: Urea transport via diffusion
fast: false
modifier: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (366.1) SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES:JLR SAB m

metaM od2coa m
is: HMDB06529
initial amount: NaN
is: SBO:0000247
name: trans-Octadec-2-enoyl-CoA
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
boundary condition: false
type: Species
constant: false
is: CHEBI:50570
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_aebf674c_3ba2_4e91_81bf_c62264f50f0e
boundary condition: true
name: ATP1B1
is encoded by: hsa:481
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: A3KLL5
initial amount: NaN
constant: false

metaM 2mb2coa m
initial concentration: 1.0
is: CHEBI:57337
boundary condition: false
constant: false
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
is: HMDB02054
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345

metaM mthgxl c
is: HMDB01167
name: methylglyoxal
is: CHEBI:17158
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r1723
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#
reversible: false
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110047#

metaR r0443
reactant: MODEL1310110047#
fast: false
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110047#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM but e
initial concentration: 1.0
name: butyrate
has only substance units: false
is: CHEBI:17968
is: HMDB00039
constant: false
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
type: Species
boundary condition: false
initial amount: NaN

metaM dhap e
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: CHEBI:57642
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01473
name: glycerone phosphate(2-)

metaM his L m
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
initial amount: NaN
has only substance units: false
name: L-histidine
is: HMDB00177
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_58fd1521_12c5_49bf_971e_b114e61a6e98
type: Species
is encoded by: hsa:9061
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: PAPSS1
initial amount: NaN
is: O43252

http://identifiers.org/biomodels.db/MODEL1310110047#_b968e158_7c4a_4806_88ab_afae6cfa3846
is: E9PB82
is: SBO:0000252
has only substance units: false
name: HSD17B4
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3295
initial concentration: NaN
type: Species

metaM hdcoa c
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB06532
constant: false
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110047#_9ab6786f_ca99_40d8_9e98_ba7b5124abb9
initial amount: NaN
is: Q9Y227
type: Species
has only substance units: false
is encoded by: hsa:9583
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: ENTPD4

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_74f16761_7e4c_4897_8c72_b2efc30369af
is: SBO:0000252
is encoded by: hsa:6342
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: SCP2
has only substance units: false
is: C9JC79
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_1c3d87bd_5b5b_412d_aa08_3347e6d62f17
boundary condition: true
has part: P31350
name: RRM1:RRM2
has part: P23921
constant: false
is encoded by: hsa:6241
is: SBO:0000297
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6240

metaR CMPACNAtg
fast: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
name: CMP-Sia Golgi transport via CMP antiport
is: SBO:0000185
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
is described by: ECO:0000269
reversible: true

metaM pep c
has only substance units: false
initial concentration: 1.0
is: C00074
boundary condition: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: HMDB00263
name: Phosphoenolpyruvate
is: SBO:0000247
initial amount: NaN
is: CHEBI:18021
constant: false
type: Species

metaM amet m
has only substance units: false
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
type: Species
initial concentration: 1.0
is: HMDB01185
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: S-Adenosyl-L-methionine
is: CHEBI:15414

metaM phe L e
initial concentration: 1.0
name: L-phenylalanine
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: SBO:0000247
is: HMDB00159
initial amount: NaN
is: CHEBI:17295
type: Species
boundary condition: false
has only substance units: false

metaR UGLCNACtg
reversible: true
type: Reaction
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
product: MODEL1310110047#
name: UDP-GlcNAc Golgi transport via CMP antiport

http://identifiers.org/biomodels.db/MODEL1310110047#_2d15b13e_7b70_442b_8ee1_86907cc79e6b
initial concentration: NaN
is encoded by: hsa:2629
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: B7Z5G2
has only substance units: false
name: GBA
is: SBO:0000252

metaM 5dhf e
initial concentration: 1.0
constant: false
name: pentaglutamyl folate (DHF)
boundary condition: false
type: Species
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB06487

http://identifiers.org/biomodels.db/MODEL1310110047#_6c9c0093_0075_4757_8613_0ea93a1e442d
name: ST6GAL1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:6480
is: B2R513
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_78490fa7_8d2b_424b_93be_d4181ffcb94e
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: P50053
boundary condition: true
has only substance units: false
is encoded by: hsa:3795
constant: false
name: KHK

metaR C4tcx
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaR SERPT
fast: false
name: serine C-palmitoyltransferase
is: SBO:0000176
reactant: MODEL1310110047#
reversible: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.50
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_b206b093_3e6b_433c_9474_6efb1d6a4cc4
is: SBO:0000252
name: LDHA
is encoded by: hsa:3939
constant: false
is: P00338
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR HMBS
fast: false
is: SBO:0000176
name: hydroxymethylbilane synthase
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
is described by: ECO:0000254
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.5.1.61
reversible: false
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#

metaR SUBERICACT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR r2055
is: SBO:0000185
reversible: false
product: MODEL1310110047#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_aaa87480_0a37_4f82_a591_2beb73dd3504
is: SBO:0000252
is encoded by: hsa:5138
is: Q8IW54
name: PDE2A
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_24774eb7_c8e6_4655_b9be_f3ad0648e43e
constant: false
is: SBO:0000252
name: PIGQ
initial concentration: NaN
is: B2RAU6
has only substance units: false
type: Species
is encoded by: hsa:9091
initial amount: NaN
boundary condition: true

metaR r0553
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: true
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaM dhap c
type: Species
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
is: C00111
constant: false
is: CHEBI:57642
is: HMDB01473
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Dihydroxyacetone phosphate

metaR ADSK
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
name: adenylyl-sulfate kinase

metaR PUNP7
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Xanthosine)
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110047#

metaM 3dphb m
type: Species
is: HMDB06251
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
name: 3-Decaprenyl-4-hydroxybenzoate
has only substance units: false
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3b70be32_ea63_43c3_bb51_77c36fd86b1f
is: SBO:0000252
name: ADCY4
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:196883
initial amount: NaN
type: Species
is: Q8NFM4
initial concentration: NaN

metaM ksii core2 deg8 l
is: SBO:0000247
is: CHEBI:12936
constant: false
name: keratan sulfate II (core 2-linked), degradation product 8
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110047#_4c34dbd3_8d2d_4ce6_aa8d_5397ea9d0d3f
initial concentration: NaN
type: Species
initial amount: NaN
name: FASN
boundary condition: true
is: P49327
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2194

metaM mi1p D c
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58433
is: HMDB02985
boundary condition: false
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
initial concentration: 1.0

metaM f1a l
initial concentration: 1.0
name: F1alpha
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02917
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
is: CHEBI:17151
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8031fd8b_c15b_40c0_bc1d_5402e694ad21
has only substance units: false
boundary condition: true
name: DBT
type: Species
initial amount: NaN
is: P11182
initial concentration: NaN
is encoded by: hsa:1629
is: SBO:0000252
constant: false

metaM mercppyr c
constant: false
initial amount: NaN
name: 3-mercaptopyruvate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
boundary condition: false
is: SBO:0000247
is: HMDB01368
type: Species
is: CHEBI:57678

metaR AMANK
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110047#
reversible: false
name: N-acetyl-D-mannosamine kinase
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.59
fast: false
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269

metaR r0552
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
modifier: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaM phe L c
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
constant: false
is: SBO:0000247
is: HMDB00159
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:17295

metaR GALASE15ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110047#
name: beta-galactosidase, lysosomal
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM cytd m
has only substance units: false
name: cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
constant: false
is: SBO:0000247
is: HMDB00089
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17562

metaM tettet6coa c
boundary condition: false
is: HMDB06516
is: SBO:0000247
is: C16171
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/47205481
initial concentration: 1.0
name: tetracosatetraenoyl coenzyme A
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1

metaR UMPK3n
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP),nuclear
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110047#
reversible: true

metaM gdpfuc c
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: CHEBI:57984
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: GDP-L-fucose(2-)
is: HMDB01095
type: Species
is: SBO:0000247
initial amount: NaN

metaM HC01842 c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial amount: NaN
type: Species
initial concentration: 1.0
name: Phosphodimethylethanolamine
boundary condition: false
is: CHEBI:31997
constant: false

metaM dlnlcg c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
constant: false
type: Species
is: HMDB02925
boundary condition: false
is: CHEBI:53486
name: dihomo-gamma-linolenic acid (n-6)
initial amount: NaN
is: SBO:0000247

metaR B3GNT35g
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
reversible: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_28cabf0e_71dd_47b9_9a21_8ddbcac62488
is: Q9Y345
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: SLC6A5
is encoded by: hsa:9152
initial concentration: NaN
boundary condition: true

metaR GBAl
type: Reaction
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.2.1.45
is: SBO:0000176
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#
name: Glucosylceramidase
modifier: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reversible: false

metaM ile L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: L-isoleucine
has only substance units: false
type: Species
is: CHEBI:17191
is: HMDB00172
initial concentration: 1.0

metaM CE5132 c
type: Species
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_026fd4ac_4906_4e71_b01a_8e6cee225cc5
is: P19367
is encoded by: hsa:3098
type: Species
initial amount: NaN
boundary condition: true
name: HK1
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaM ksi pre17 g
constant: false
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 17
notes: FORMULA: C157H252N11O127S5X CHARGE: -6

metaM hexdiac r
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C16H28O4 CHARGE: -2
is: HMDB00672
constant: false
boundary condition: false
initial concentration: 1.0
is: C08260
name: hexadecanediocacid
type: Species

metaM 5eipencoa m
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: 5,8,11,14,17-eicosapentenoylcoa
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
boundary condition: false

metaM drib e
name: 2-deoxy-D-ribose
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28816
is: SBO:0000247
is: HMDB03224
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_7cf5160e_4268_4111_97ae_0ca43a9226ee
type: Species
is: P23634
boundary condition: true
initial concentration: NaN
is encoded by: hsa:493
name: ATP2B4
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR AG13T7g
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
reversible: false
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR It
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
reactant: MODEL1310110047#
is described by: ECO:0000269
name: Iodide uniport
fast: false

metaM retinal cis 13 c
name: 13-cis-retinal
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
constant: false
initial concentration: 1.0
type: Species
is: HMDB06220

metaR PUNP5
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
fast: false
name: purine-nucleoside phosphorylase (Inosine)
product: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110047#_fd33a5e3_0910_4c92_bb42_567e56fc80a9
boundary condition: true
constant: false
has only substance units: false
is: Q14353
name: GAMT
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2593
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_67eaf8c1_02bc_48fe_96bd_39477e6acb6e
initial concentration: NaN
name: ACO2
is: Q99798
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:50
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_a8f95678_e52f_4971_b3e8_d757ea33bfbd
type: Species
name: FUK
has only substance units: false
is: SBO:0000252
is: Q8N0W3
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:197258

metaR r2321
fast: false
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_28aa7ad7_69ab_4716_91c0_f8a5c32182ba
is encoded by: hsa:4720
name: NDUFS2
is: B7Z792
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR THBPT4ACAMDASE
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110047#
is: SBO:0000176
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase

metaM dgchol e
has only substance units: false
is: HMDB00637
type: Species
is: SBO:0000247
boundary condition: false
name: glycochenodeoxycholate
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_244fa786_d860_49dc_a7ec_0cb4c1975d0f
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _AI971023_1_c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI971023

metaR PROt4 2 r
is described by: ECO:0000006
name: Proline transport (sodium symport) (2:1)
modifier: MODEL1310110047#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
type: Reaction

metaR DSAT
kinetic law: MODEL1310110047#
name: dihydrosphingosine N-acyltransferase
product: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_f36ac687_18a6_4e94_b1c5_4abb0263ae97
is encoded by: hsa:6480
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: ST6GAL1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_491c876b_47da_47dc_a666_49199b3bcd64
initial amount: NaN
is encoded by: hsa:79717
type: Species
constant: false
boundary condition: true
is: Q9HAB8
has only substance units: false
name: PPCS
initial concentration: NaN
is: SBO:0000252

metaR PUNP6
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyinosine)
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110047#_7a48e3cf_e2a2_4333_95ea_86c69f5d7b6a
is: P21399
initial amount: NaN
is encoded by: hsa:48
constant: false
has only substance units: false
name: ACO1
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM hdca e
is: SBO:0000247
is: C00249
boundary condition: false
constant: false
type: Species
is: CHEBI:0
initial amount: NaN
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1
is: HMDB00220

http://identifiers.org/biomodels.db/MODEL1310110047#_95c36360_5108_4f27_b08a_c457fd9a0ab3
initial amount: NaN
initial concentration: NaN
name: PLA2G4A
is encoded by: hsa:5321
has only substance units: false
constant: false
is: SBO:0000252
is: P47712
boundary condition: true
type: Species

metaR SARDHm
kinetic law: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.99.1
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is: SBO:0000176
name: Sarcosine dehydrogenase (m)

http://identifiers.org/biomodels.db/MODEL1310110047#_01be53bc_e81b_4cf6_a4ff_6802576c6695
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: PKLR
is encoded by: hsa:5313
has only substance units: false
constant: false
boundary condition: true

metaR GALASE19ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reversible: false
name: beta-galactosidase, lysosomal
is: SBO:0000176

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ac4161e5_51da_42e5_a9ca_b5d7b3d477c6
is encoded by: hsa:57835
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: SLC4A5
initial amount: NaN

metaR r2320
reactant: MODEL1310110047#
type: Reaction
reversible: true
fast: false
product: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_2b8bb641_82dc_499f_a59e_05f9b8fa9879
is encoded by: hsa:284273
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ZADH2
constant: false
is: SBO:0000252
is: Q8N4Q0

metaR r1179
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
kinetic law: MODEL1310110047#
name: EC:3.1.1.13
reversible: false
is: SBO:0000176
reactant: MODEL1310110047#
type: Reaction
fast: false
product: MODEL1310110047#
is described by: ECO:0000000

metaR r0974
reversible: true
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110047#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
product: MODEL1310110047#

metaR MERCPLACCYSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
reversible: false
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000000
name: 3-mercaptolactate-cysteine disulfide transport, extracellular

http://identifiers.org/biomodels.db/MODEL1310110047#_3bf4bd38_87fd_428e_84ec_77dd1f6f4e91
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:6898
name: TAT
is: SBO:0000252
type: Species
boundary condition: true
is: P17735

metaR PUNP3
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Guanosine)
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_ae98fb21_32bb_4af6_8d43_3e681fe614d4
boundary condition: true
initial amount: NaN
constant: false
is: P35557
initial concentration: NaN
is encoded by: hsa:2645
type: Species
is: SBO:0000252
has only substance units: false
name: GCK

metaM phyt2ohcoa x
name: 2-hydroxyphytanoyl-CoA(4-)
boundary condition: false
constant: false
has only substance units: false
is: HMDB01295
initial amount: NaN
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57334

http://identifiers.org/biomodels.db/MODEL1310110047#_6425efdb_3991_4e9e_8438_b771ed4317f1
name: TKTL2
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q9H0I9
boundary condition: true
is encoded by: hsa:84076
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_a53e431f_efff_4d1d_95b2_79a66489ff8c
type: Species
is: Q99755
initial amount: NaN
is encoded by: hsa:8394
constant: false
initial concentration: NaN
name: PIP5K1A
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR FAOXC201C181x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM xol7a r
is: HMDB01496
type: Species
is: CHEBI:1296
initial amount: NaN
constant: false
name: 20-hydroxycholesterol
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r2323
type: Reaction
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaM gly m
is: C00037
name: Glycine
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
type: Species
constant: false
is: HMDB00123
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR ELAIDt
name: fatty acid transport via diffusion
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false

metaM dgchol c
type: Species
is: HMDB00637
boundary condition: false
name: glycochenodeoxycholate
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR DHPM1
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
reactant: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.5.2.2
type: Reaction
is: SBO:0000176
product: MODEL1310110047#
name: dihydropyrimidinase (5,6-dihydrouracil)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_1f6078d2_f19c_4de1_83a1_4d0cb934a52f
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:10400
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: PEMT

metaM gdpfuc g
type: Species
is: HMDB01095
is: SBO:0000247
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: CHEBI:57984
constant: false
boundary condition: false
has only substance units: false
name: GDP-L-fucose(2-)
initial amount: NaN
initial concentration: 1.0

metaR PUNP4
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
reactant: MODEL1310110047#
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110047#
name: purine-nucleoside phosphorylase (Deoxyguanosine)

metaR LCADi D
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
reactant: MODEL1310110047#
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
type: Reaction
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR XYLt
is described by: ECO:0000269
modifier: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
name: D-xylose reversible transport
kinetic law: MODEL1310110047#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_36681196_0f3a_4619_aa23_5743ac6b8d25
type: Species
is encoded by: hsa:55350
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: VNN3

metaM hdca c
is: HMDB00220
name: palmitate
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM 2oxoadp m
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: 2-oxoadipate(2-)
boundary condition: false
is: CHEBI:57499
is: HMDB00225
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_ad06970c_db0a_4c73_8d24_afcd4845585b
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4967
is: B4E3E9
constant: false
is: SBO:0000252
name: OGDH
boundary condition: true

metaR r2322
reactant: MODEL1310110047#
type: Reaction
fast: false
reversible: true
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110047#

metaR CHLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
name: choline transport via diffusion (cytosol to mitochondria)
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaM ksi deg18 l
is: CHEBI:12936
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00143
name: keratan sulfate I, degradation product 18

metaR FAOXC122C101m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaM 2mp2coa m
is: HMDB01011
is: SBO:0000247
is: CHEBI:27754
type: Species
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial amount: NaN
boundary condition: false
name: 2-Methylprop-2-enoyl-CoA
has only substance units: false
initial concentration: 1.0

metaR DHPM2
product: MODEL1310110047#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110047#
name: dihydropyrimidinase (dihydrothymine)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information

metaM dgtp n
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
is: CHEBI:16497
name: dGTP
boundary condition: false
is: C00286
constant: false
type: Species
initial amount: NaN
is: HMDB01440
has only substance units: false

metaR BAMPPALDOX
product: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
kinetic law: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110047#
is described by: ECO:0000212

metaM lnlncgcrn c
name: gamma-linolenyl carnitine
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB06318
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8197a86c_d8c3_4228_bb61_736589f010d8
name: SLC2A9
is encoded by: hsa:56606
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9NRM0

metaR r2324
type: Reaction
product: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true

metaR TAGAT Dt
product: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: D-tagatose uptake via diffusion
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
fast: false

metaM his L e
boundary condition: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15971
name: L-histidine
type: Species
constant: false
is: HMDB00177
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_e5873bd7_e12c_43f1_8e3c_678a112e4e86
type: Species
constant: false
is: Q14916
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC17A1
is encoded by: hsa:6568
initial concentration: NaN
boundary condition: true

metaR PCHOLHSTDe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: PCHOLHSTDe
type: Reaction

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaR RETNt
type: Reaction
name: retinoic acid transport
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
is: SBO:0000185
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_651e4e4a_1f91_4355_ab2d_1b47440ff34b
boundary condition: true
name: SLC13A3
has only substance units: false
initial amount: NaN
type: Species
is: B4DIR8
is encoded by: hsa:64849
is: SBO:0000252
initial concentration: NaN
constant: false

metaM HC01231 c
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:58480

metaM c51crn c
initial amount: NaN
name: tiglyl carnitine
is: HMDB02366
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C12H21NO4 CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_0cc46636_0f70_4070_a166_a43c2fda3cc5
name: GAL3ST1
constant: false
is encoded by: hsa:9514
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q99999

metaR NACHEX15ly
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110047#

metaR RDH2a
is version of: http://identifiers.org/ec-code/1.1.1.300
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
kinetic law: MODEL1310110047#
name: retinol dehydrogenase (9-cis,NADPH)
modifier: MODEL1310110047#
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110047#

metaR 4MOPt2im
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_014454a9_4711_46b7_a289_2f385aea697b
is encoded by: hsa:117248
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: Q8N3T1
initial concentration: NaN
name: GALNTL2

metaR UMPK5
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase (dATP)
product: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#

metaR BTNt2
modifier: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
name: Biotin reversible transport via proton symport
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110047#
fast: false

metaR PUNP2
reactant: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyadenosine)
modifier: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110047#_ef89a698_a439_4d96_b01d_d5c4e4460d15
has only substance units: false
is: P22680
is encoded by: hsa:1581
name: CYP7A1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c4ff23d3_043e_48c3_b7be_e9e745c38069
is encoded by: hsa:6532
name: SLC6A4
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P31645
constant: false
is: SBO:0000252
has only substance units: false
type: Species

metaR r2325
product: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110047#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110047#
is described by: ECO:0000000

metaR FRDPtc
kinetic law: MODEL1310110047#
name: lipid, flip-flop intracellular transport
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction

metaR r1924
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR C101CRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR AMPtp
name: AMP transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
kinetic law: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110047#_82142809_f4e0_4eb6_acec_6bfd7c7a1a6e
initial concentration: NaN
is encoded by: hsa:55967
boundary condition: true
is: F8VQS7
name: NDUFA12
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

metaR 3AIB Dtm
reactant: MODEL1310110047#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110047#
name: transport of 3aib_D into mitochondria
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_c5c98ae3_944f_43c7_9431_971f280118f6
has only substance units: false
constant: false
name: FUT8
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2530
initial amount: NaN
boundary condition: true
is: B4DFS7
type: Species

metaR PUNP1
modifier: MODEL1310110047#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Adenosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM ttdcrn c
initial concentration: 1.0
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
constant: false
boundary condition: false
is: HMDB05066
name: tetradecanoyl carnitine
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3413344
initial amount: NaN

metaR UMPK4
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110047#
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
modifier: MODEL1310110047#
reversible: true
product: MODEL1310110047#
is described by: ECO:0000269

metaM mi34p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
has only substance units: false
constant: false
type: Species
is: CHEBI:28858
is: HMDB06235
name: 1D-myo-Inositol 3,4-bisphosphate
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM dpcoa c
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57328
name: Dephospho-CoA
constant: false
type: Species
initial amount: NaN
is: HMDB01373
is: C00882

metaM c51crn e
is: HMDB02366
notes: FORMULA: C12H21NO4 CHARGE: 0
name: tiglyl carnitine
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

metaM his L c
is: CHEBI:15971
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB00177
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
initial concentration: 1.0

metaR DM ethamp r
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR r2326
reversible: true
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false

metaR HEXCt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
reversible: true
product: MODEL1310110047#
fast: false

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaM bildglcur c
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
is: SBO:0000247
is: CHEBI:58471
constant: false

metaR AGTim
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.44
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is: SBO:0000176
name: alanine-glyoxylate transaminase (irreversible), mitochondrial

metaR UMPK3
reversible: true
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110047#
name: UMP kinase (UTP)

metaM dece4coa x
name: 4-decenoylcoa
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02145
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN

metaR H2O2t
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110047#
name: hydrogen peroxide transport via diffusion
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction

metaR RNDR3
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110047#
reversible: false
name: ribonucleoside-diphosphate reductase (CDP)
is: SBO:0000176

metaR SEBACIDTD
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM crm hs c
type: Species
boundary condition: false
constant: false
name: N-acylsphingosine
is: SBO:0000247
initial amount: NaN
is: CHEBI:52639
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR PSERT
type: Reaction
reversible: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000269
name: phosphoserine transaminase
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.52

metaR ASPTA
reactant: MODEL1310110047#
is: SBO:0000176
name: aspartate transaminase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
modifier: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_b4911150_4710_42d2_add4_df162055c004
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2109
is: SBO:0000252
initial amount: NaN
name: ETFB
type: Species

metaM cholcoas x
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA(S)
constant: false
type: Species
has only substance units: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:37643

metaR r0666
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000176
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true

metaR r2327
is: SBO:0000185
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

metaR UMPK2
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (CTP)
product: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaM cdpea c
is: HMDB01564
is: CHEBI:57876
name: cdpea[c]
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_79a58ad9_2fa4_4830_a54e_9b5579aa206e
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:26330
is: O14556
type: Species
name: GAPDHS

metaR ADSS
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: adenylosuccinate synthase
modifier: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_42a1d2c5_837e_420c_b868_6601788a9e8a
is encoded by: hsa:5052
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q06830
name: PRDX1
type: Species
initial concentration: NaN

metaM glyc m
initial concentration: 1.0
is: C00116
is: CHEBI:17754
boundary condition: false
name: Glycerol
is: HMDB00131
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_8037d2b5_841c_4c2d_9f0b_b8a0d406f2bf
initial amount: NaN
is: Q9HAS3
boundary condition: true
has only substance units: false
name: SLC28A3
is: SBO:0000252
type: Species
is encoded by: hsa:64078
initial concentration: NaN
constant: false

metaR DRPA
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
type: Reaction
name: deoxyribose-phosphate aldolase
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:

metaR S23T4g
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.99.4

metaM utp e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: UTP(4-)
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
is: HMDB00285
has only substance units: false

metaR FACOAL1812
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110047#
is: SBO:0000176

metaR FAOXC184m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR S6T17g
is described by: ECO:0000000
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
fast: false
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110047#
type: Reaction

metaM dpcoa e
is: SBO:0000247
is: CHEBI:57328
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB01373
is: C00882
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
boundary condition: false
name: Dephospho-CoA

metaM ficytC m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15991
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
boundary condition: false
name: Ferricytochrome c

metaM pcrn x
is: HMDB00824
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: propionyl-carnitine
type: Species
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

metaR r0009
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
type: Reaction

metaR RNDR1
modifier: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110047#
name: ribonucleoside-diphosphate reductase (ADP)
product: MODEL1310110047#
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1

metaM hexdiac c
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: hexadecanediocacid
notes: FORMULA: C16H28O4 CHARGE: -2
initial amount: NaN
is: SBO:0000247
is: HMDB00672
constant: false
is: C08260

metaR LYStm
product: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
name: Lysine mitochondrial transport via ornithine carrier
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_235f21ff_c7e2_437a_b26e_0eacb7d6c7f9
is encoded by: hsa:51
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ACOX1
is: Q15067
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_436755b8_be8d_469b_971e_a7504cdb0427
is: SBO:0000252
name: ENPP3
initial concentration: NaN
type: Species
is encoded by: hsa:5169
constant: false
initial amount: NaN
boundary condition: true
is: Q308M7
has only substance units: false

metaM bildglcur e
is: CHEBI:58471
constant: false
is: HMDB03325
is: SBO:0000247
boundary condition: false
type: Species
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaR T4HCINNMFM
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
name: 4-hydroxycinnamate formation
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110047#

metaR r2328
product: MODEL1310110047#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_75f3626a_af3e_420d_9062_f50fff617eef
type: Species
has only substance units: false
is: P35219
is encoded by: hsa:767
boundary condition: true
initial amount: NaN
name: CA8
constant: false
initial concentration: NaN
is: SBO:0000252

metaR LYStiDF
type: Reaction
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reactant: MODEL1310110047#
name: L-lysine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000269
reversible: false

metaR r0668
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.19
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
fast: false
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
reversible: true

metaR GLCNACT U
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110047#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM k e
has only substance units: false
is: HMDB00586
initial concentration: 1.0
is: C00238
constant: false
boundary condition: false
initial amount: NaN
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: SBO:0000247
is: CHEBI:29103
type: Species

metaR FACOAL1813
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
name: fatty-acid--CoA ligase
reactant: MODEL1310110047#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110047#
type: Reaction

metaM dgcholcoa x
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461
is: SBO:0000247
is: C05461
constant: false
boundary condition: false
type: Species
is: HMDB06897
has only substance units: false
name: Chenodeoxyglycocholoyl-CoA

metaM xoldiolone r
has only substance units: false
boundary condition: false
is: HMDB02197
initial amount: NaN
type: Species
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: SBO:0000247
is: CHEBI:28477
initial concentration: 1.0
constant: false

metaM mhista c
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
has only substance units: false
initial amount: NaN
boundary condition: false
name: N(tele)-methylhistaminium
is: CHEBI:58600
type: Species
is: SBO:0000247
constant: false
is: HMDB00898
initial concentration: 1.0

metaM prpncoa m
is: HMDB02307
initial amount: NaN
constant: false
is: CHEBI:57367
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: acryloyl-CoA(4-)
boundary condition: false

metaR CYTK2n
reversible: true
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
name: cytidylate kinase (dCMP),nuclear
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_591abc1a_a18e_408e_8663_2676b1891ccd
type: Species
constant: false
name: PMVK
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10654
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q6FGV9

metaR r2329
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#

metaR GLUPRT
type: Reaction
is: SBO:0000176
name: glutamine phosphoribosyldiphosphate amidotransferase
reversible: false
modifier: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.14
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269
reactant: MODEL1310110047#

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM 4hexdtetcoa x
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
name: 4,7,10,13-hexadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110047#_11fe3f00_8e09_4264_a7b6_ad6c0550e549
type: Species
is encoded by: hsa:144195
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC2A14
is: SBO:0000252
boundary condition: true
is: Q8TDB8
has only substance units: false

metaR r0669
reversible: false
is: SBO:0000176
reactant: MODEL1310110047#
is described by: ECO:0000000
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:

metaR NACHEX13ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
fast: false
reactant: MODEL1310110047#
reversible: false
is described by: ECO:0000000

metaM g2m8mpdol U r
type: Species
is: CHEBI:59093
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
constant: false
has only substance units: false

metaM utp c
is: HMDB00285
initial amount: NaN
name: UTP
boundary condition: false
is: C00075
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: SBO:0000247
type: Species
is: CHEBI:46398
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_748ecc83_e82f_4ba8_ad50_8f7db37ea65f
is encoded by: hsa:3156
name: HMGCR
is: P04035
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_dbc806ff_5daa_429c_adab_744d7604a997
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: A0PJJ9
type: Species
name: GGT7
is encoded by: hsa:2686
initial amount: NaN

metaR ESTRADIOLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: estradiol intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_77111453_b43d_4cc1_b34c_eebb4c548499
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8574
is: O43488
name: AKR7A2
boundary condition: true
has only substance units: false

metaR UMPK7
reactant: MODEL1310110047#
name: UMP kinase (dGTP)
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR GLCt4
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185
name: glucose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
fast: false
product: MODEL1310110047#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_f596f433_d486_4d5e_b031_5c98d2058764
has only substance units: false
boundary condition: true
is encoded by: hsa:3145
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: P08397
type: Species
name: HMBS

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM 3hdececrn c
name: 3-hydroxyhexadecenoylcarnitine
is: HMDB02014
has only substance units: false
constant: false
notes: FORMULA: C23H43NO5 CHARGE: 0
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR CSAPASEly
is described by: ECO:0000000
reactant: MODEL1310110047#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110047#
fast: false
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)

http://identifiers.org/biomodels.db/MODEL1310110047#_12a64907_8b76_46eb_bbec_6c961479272c
name: PIGP
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:51227
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_9060670f_3dae_4d01_9aa7_c96b96f86df8
is: SBO:0000252
name: GSR
is: P00390
initial amount: NaN
type: Species
is encoded by: hsa:2936
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaR RE1519M
modifier: MODEL1310110047#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
reactant: MODEL1310110047#
name: RE1519
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaM k c
is: C00238
constant: false
initial concentration: 1.0
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
has only substance units: false
is: CHEBI:29103
name: potassium
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00586

http://identifiers.org/biomodels.db/MODEL1310110047#_d1a9599a_9a16_488e_9e84_b0867f5a586c
has only substance units: false
name: PC
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P11498
is encoded by: hsa:5091

metaR UMPK6
name: UMP kinase (dCTP)
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000269
reversible: true

metaM cs e deg3 l
is: HMDB00127
constant: false
initial amount: NaN
notes: FORMULA: C37H53NO44S4 CHARGE: -6
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
type: Species
is: CHEBI:15748
is: SBO:0000247

metaR P45011A1m
is described by: ECO:0000269
reactant: MODEL1310110047#
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reversible: false
product: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.14.15.6

http://identifiers.org/biomodels.db/MODEL1310110047#_d51d12b6_2a68_4839_867e_132d777ec6e4
is: E7EUT4
is encoded by: hsa:2597
has only substance units: false
boundary condition: true
initial concentration: NaN
name: GAPDH
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaM hs l
is: SBO:0000247
boundary condition: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
constant: false
initial concentration: 1.0
name: heparan sulfate, free chain
initial amount: NaN
type: Species
is: CHEBI:28815
has only substance units: false

metaM xoltriol m
is: HMDB01457
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: CHEBI:16496
constant: false
boundary condition: false

metaR LYStn
fast: false
is: SBO:0000185
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: L-lysine transport, nuclear
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_f0856c00_72cb_4033_ab33_a31769b3f5cf
boundary condition: true
name: HSD17B4
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: E9PB82
is encoded by: hsa:3295

metaM nmn c
initial amount: NaN
is: HMDB00229
is: C00455
is: CHEBI:14649
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
name: NMN
constant: false

metaR 5MTAte
name: Transport of 5-S-methyl-5-thioadenosine
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110047#

metaM ins e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00195
is: CHEBI:17596
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
type: Species
constant: false
is: C00294
name: Inosine

metaR FAOXC226C225m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaM prostgi2 e
type: Species
initial concentration: 1.0
name: prostaglandin I2(1-)
initial amount: NaN
constant: false
is: HMDB01335
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
has only substance units: false
is: CHEBI:57403

metaM retinol c
has only substance units: false
is: CHEBI:50211
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247
constant: false
is: HMDB00305
name: retinol

metaM CE2424 m
initial concentration: 1.0
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: SBO:0000247
boundary condition: false
is: CHEBI:28387
constant: false
initial amount: NaN
type: Species
is: HMDB11123
has only substance units: false

metaR RE0690E
product: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
modifier: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110047#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: RE0690
type: Reaction

metaM CE5786 e
constant: false
is: SBO:0000247
is: HMDB02710
has only substance units: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
type: Species
initial concentration: 1.0
is: CHEBI:27485
boundary condition: false
name: kinetensin
initial amount: NaN

metaR EX CE4724 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: apelin (1-12) exchange
type: Reaction

metaR DASPO1p
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
type: Reaction
is: SBO:0000176
name: D-aspartate oxidase, peroxisomal
is version of: http://identifiers.org/ec-code/1.4.3.1
reversible: false
reactant: MODEL1310110047#

metaM 2oxoadp c
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 2-oxoadipate(2-)
boundary condition: false
has only substance units: false
is: CHEBI:57499
is: HMDB00225
initial amount: NaN

metaM 5fthf m
name: 5-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: CHEBI:57457
boundary condition: false
initial amount: NaN
is: HMDB01562
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR 5MTHFt
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
fast: false
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
reactant: MODEL1310110047#
type: Reaction
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_7ed2a33f_750f_4e22_8ed1_930d92f43efd
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:771
is: SBO:0000252
type: Species
name: CA12

metaM dece4coa m
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB02145
initial concentration: 1.0
name: 4-decenoylcoa
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
constant: false

metaM 5hoxindact c
has only substance units: false
constant: false
is: HMDB04073
is: CHEBI:50157
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: (5-hydroxyindol-3-yl)acetaldehyde
initial concentration: 1.0
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634

metaR PHACCOAGLNAC
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
type: Reaction
fast: false
is described by: ECO:0000000

metaR SPMTDe
kinetic law: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#
name: SPMTDe
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_b47d11b7_c577_474b_8759_945d0ae3a68d
initial concentration: NaN
initial amount: NaN
is: O14772
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: FPGT
is encoded by: hsa:8790
has only substance units: false

metaM cspg a e
is: HMDB00300
constant: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00106
is: CHEBI:17568
notes: FORMULA: C45H66N2O45S3X CHARGE: -5

metaR ORNTArm
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
reversible: true
kinetic law: MODEL1310110047#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.6.1.13
name: ornithine transaminase reversible (m)

metaR THYMt
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
reversible: true
product: MODEL1310110047#
name: thymine reversible transport via facilated diffusion

metaM CE5853 e
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
has only substance units: false
constant: false
is: CHEBI:57923
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: alpha-CEHC-glucuronide
initial amount: NaN
type: Species

metaR CLS hs
name: cardiolipin synthase (homo sapiens)
kinetic law: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
reversible: false
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
is described by: ECO:0000000

metaR GULLACter
reversible: false
kinetic law: MODEL1310110047#
name: gulonolactone endoplasmic reticular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
fast: false

metaR r0870
type: Reaction
reversible: true
modifier: MODEL1310110047#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.3.4
fast: false
product: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.4.13
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_67b0f6ab_f46d_42dd_9efb_be82de6c57c9
boundary condition: true
is encoded by: hsa:9197
constant: false
has only substance units: false
type: Species
is: O00400
initial amount: NaN
is: SBO:0000252
name: SLC33A1
initial concentration: NaN

metaR VALPHELAT2tc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#
is: SBO:0000176
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM ppa e
boundary condition: false
type: Species
is: HMDB00237
initial concentration: 1.0
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
has only substance units: false
name: propionate
constant: false
is: SBO:0000247

metaM pglyc hs c
is: CHEBI:60523
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: phosphatidylglycerol(1-)
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
is: CHEBI:26174
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: I-antigen
type: Species
constant: false

metaM but m
is: HMDB00039
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
is: CHEBI:17968
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR THFtm
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reactant: MODEL1310110047#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000

metaR r2200
type: Reaction
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#

metaM 3hdececrn e
type: Species
is: SBO:0000247
name: 3-hydroxyhexadecenoylcarnitine
has only substance units: false
initial amount: NaN
constant: false
is: HMDB12930
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C23H43NO5 CHARGE: 0

metaM cs a deg4 l
initial concentration: 1.0
is: CHEBI:16953
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
is: HMDB00812
boundary condition: false
initial amount: NaN

metaR RE0828E
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
name: RE0828
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110047#

metaR HSD11B2r
type: Reaction
name: 11-beta-hydroxysteroid dehydrogenase type 2
reactant: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.146
modifier: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#
is: SBO:0000176

metaM lnlncgcrn m
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
has only substance units: false
is: SBO:0000247
name: gamma-linolenyl carnitine
boundary condition: false
initial amount: NaN
is: HMDB06318

metaM 2dodtricoa x
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 2,6,9-dodecatrienoylcoa
is: C05279
type: Species
is: HMDB11123
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR r0871
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
name: Diffusion
reversible: true

metaM prostgi2 c
initial concentration: 1.0
name: prostaglandin I2(1-)
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01335
is: SBO:0000247
is: CHEBI:57403

metaM ins c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00195
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: CHEBI:17596
type: Species
constant: false
name: Inosine
is: C00294
boundary condition: false

metaM gdpddman c
constant: false
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
is: CHEBI:57964
has only substance units: false
is: HMDB01346
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM ddsmsterol r
boundary condition: false
name: 7-dehydrodesmosterol
is: SBO:0000247
is: CHEBI:27910
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: HMDB03896
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373

metaR r2201
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110047#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
reversible: true

metaM HC01231 m
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
is: CHEBI:58480
type: Species

metaM ksii core2 pre1 g
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 1
notes: FORMULA: C33H53N3O23X CHARGE: -1
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM gudac c
notes: FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
is: HMDB00128
initial amount: NaN
boundary condition: false
is: CHEBI:16344
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: guanidinoacetic acid
type: Species

metaM 5hoxindoa c
constant: false
name: 5-Hydroxyindoleacetate
type: Species
has only substance units: false
is: HMDB00763
is: SBO:0000247
is: CHEBI:27823
initial concentration: 1.0
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_36c5ea7c_e6ef_40b6_a851_368bf3b99a06
is encoded by: hsa:1718
name: DHCR24
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q15392
initial concentration: NaN
is: SBO:0000252

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM dgchol x
is: HMDB00637
is: CHEBI:36252
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
constant: false
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_b6d2d6c8_8d28_48bc_a291_fb82d5ddae42
has only substance units: false
initial concentration: NaN
type: Species
name: PANK2
is: Q6P1K9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80025
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_c9072463_6b8e_43d7_bf73_ad71b3cb7308
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: GALK1
is: P51570
constant: false
is: SBO:0000252
is encoded by: hsa:2584
initial amount: NaN

metaM pyam5p c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
initial amount: NaN
name: Pyridoxamine 5'-phosphate
type: Species
is: CHEBI:58451
is: SBO:0000247
is: C00647
is: HMDB01555
has only substance units: false

metaR GAO1g
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: Ganglioside O-acetylation
reversible: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
is described by: ECO:0000269

metaM dpcoa l
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01373
constant: false
has only substance units: false
name: 3'-dephospho-CoA(2-)

metaR r2202
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
type: Reaction

metaR r0779
is described by: ECO:0000000
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reactant: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM gtp n
is: CHEBI:37565
name: GTP(4-)
has only substance units: false
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR ARACHCOAtx
fast: false
type: Reaction
reactant: MODEL1310110047#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR MMMm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000269
name: methylmalonyl-CoA mutase
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is version of: http://identifiers.org/ec-code/5.4.99.2
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_db147f6a_457d_4bcc_bdab_aee041d2f918
is: Q16222
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:6675
initial concentration: NaN
type: Species
name: UAP1
boundary condition: true

metaM acald x
initial concentration: 1.0
name: acetaldehyde
is: CHEBI:15343
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
constant: false
is: HMDB00990
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_1ceed953_cb4b_4362_a4c7_4792b00815eb
constant: false
is encoded by: hsa:2348
boundary condition: true
initial concentration: NaN
name: FOLR1
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaM gchola e
has only substance units: false
constant: false
is: HMDB00138
boundary condition: false
notes: FORMULA: C26H43NO6 CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
name: glycocholate
initial concentration: 1.0

metaR ACOAO7p
kinetic law: MODEL1310110047#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110047#
reversible: false
type: Reaction
is described by: ECO:0000269

metaR EICOSTETCPT2
is described by: ECO:0000000
fast: false
name: carnitine transferase
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110047#

metaR TAURtcx
reversible: true
fast: false
name: taurine transport (sodium symport) (cytosol to peroxisome)
is described by: ECO:0000212
modifier: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110047#_27e8dab7_5433_4d0a_8364_57c5af316657
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC8A3
initial amount: NaN
is encoded by: hsa:6547

metaM dpcoa m
is: CHEBI:57328
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
initial amount: NaN
constant: false
is: SBO:0000247
name: 3'-dephospho-CoA(2-)

metaM glyc e
type: Species
name: Glycerol
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00131
is: C00116
is: CHEBI:17754
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_be69858b_ec58_4902_a2bf_bebc31918c76
type: Species
is: Q9HBH5
is encoded by: hsa:57665
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: RDH14
has only substance units: false

metaM gtp m
name: GTP
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
initial concentration: 1.0
is: HMDB01273
constant: false
is: CHEBI:37565
is: C00044
type: Species
initial amount: NaN

metaM utp n
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: UTP(4-)
is: CHEBI:46398
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
type: Species

metaM glyc c
name: Glycerol
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: C00116
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00131

metaR r0660
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR S4TASE1ly
modifier: MODEL1310110047#
reversible: true
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
is: SBO:0000176
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal

metaR EICOSTETCPT1
modifier: MODEL1310110047#
reversible: false
is described by: ECO:0000269
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110047#
type: Reaction
fast: false
is: SBO:0000176
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110047#_88889cec_b88f_472b_8025_71cc7f323bf3
is: SBO:0000252
is: Q5TDP6
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: LGSN
is encoded by: hsa:51557

metaR r1815
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
fast: false
reversible: false
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
name: Y+LAT2 Utilized transport

metaR ABO6g
is described by: ECO:0000269
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.37
modifier: MODEL1310110047#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_a577b6c4_3887_4ed3_bae0_b2377f897abc
is: SBO:0000297
has part: P50213
is encoded by: hsa:3419
is encoded by: hsa:3420
is encoded by: hsa:3421
constant: false
initial concentration: NaN
name: IDH3A:IDH3B:IDH3G
type: Species
boundary condition: true
initial amount: NaN
has part: E9PDD5
has only substance units: false

metaR r0002
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false
type: Reaction
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reversible: true
reactant: MODEL1310110047#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_626808b2_753d_4a6a_9959_1fb1abda9ffc
has only substance units: false
name: HADH
constant: false
initial concentration: NaN
is: Q16836
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3033
type: Species
initial amount: NaN

metaM C05279 m
is: HMDB11123
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
constant: false
has only substance units: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
initial amount: NaN
is: CHEBI:28387
is: SBO:0000247
type: Species
boundary condition: false

metaR S4TASE3ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_30c0a1ec_77a3_4a09_8ff4_70dde6ce66b2
is encoded by: hsa:55349
initial concentration: NaN
type: Species
constant: false
is: Q8NE62
name: CHDH
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaM gchola c
initial amount: NaN
boundary condition: false
is: CHEBI:58235
name: glycocholate
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00138
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_5bc0ee2e_b70e_4084_92c8_915021b8abfc
has only substance units: false
is encoded by: hsa:22978
is: P49902
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NT5C2
type: Species

metaM tettet6coa x
is: SBO:0000247
is: HMDB06516
constant: false
type: Species
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false
initial concentration: 1.0
is: C16171
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205481
name: tetracosatetraenoyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110047#_b2d1037c_18d0_4817_8426_81a84779fe9a
constant: false
has only substance units: false
initial amount: NaN
is: Q9BTY2
name: FUCA2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2519
type: Species
initial concentration: NaN

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_753dc6cf_d231_4818_b227_c37ec2551edf
initial amount: NaN
has only substance units: false
is: P24666
type: Species
constant: false
name: ACP1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:52

metaR r0661
product: MODEL1310110047#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_592bf662_fec0_4b24_95a0_afb806cdbfa5
is: O95169
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:4714
name: NDUFB8
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_c21dfaf8_6997_46e9_993a_b13e504eccd1
is encoded by: hsa:80270
initial amount: NaN
name: HSD3B7
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9H2F3
constant: false

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_960d703f_7f22_4709_938b_2777db1714b2
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6549
is: Q9UBY0
name: SLC9A2
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_63e110bd_8d79_4aed_a703_954ae33b5b5a
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: NME1
has only substance units: false
type: Species
is encoded by: hsa:4830
is: P15531

http://identifiers.org/biomodels.db/MODEL1310110047#_b195da47_f2c2_4d98_86d7_2b4ae16755f2
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLC12A6
type: Species
initial amount: NaN
is encoded by: hsa:9990
is: Q9UHW9
boundary condition: true

metaR C101CPT1
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaM retinal cis 13 r
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:45487
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
boundary condition: false
constant: false
is: HMDB06220
name: 13-cis-retinal

metaM ppa c
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
is: CHEBI:17272
type: Species
has only substance units: false
name: propionate
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaM pglyc hs e
initial amount: NaN
name: phosphatidylglycerol(1-)
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
is: CHEBI:60523
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_efbb0909_4c73_42c8_af74_b11dd502c779
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: GMPS
has only substance units: false
is encoded by: hsa:8833
is: P49915

metaM pyr e
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15361
boundary condition: false
has only substance units: false
name: pyruvate
initial amount: NaN
type: Species
constant: false
is: HMDB00243

metaR r1584
fast: false
reversible: true
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_0663f0af_896d_40f2_9f23_f38c4d05b823
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6647
boundary condition: true
name: SOD1
is: P00441
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_ec896e91_70bf_4577_95ef_1704ff4c173f
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:107
initial concentration: NaN
is: Q08828
name: ADCY1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_ad6f18f0_fa44_4ab5_b1dc_a891dc70380a
name: COX6B2
boundary condition: true
has only substance units: false
type: Species
is: Q6YFQ2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:125965

metaM tchola e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0
type: Species
name: taurocholic acid
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_0c7c09be_a69a_4b04_81a2_c22b0c8396b7
constant: false
initial concentration: NaN
boundary condition: true
is: P04745
type: Species
name: AMY1C
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:278
has only substance units: false

metaM 56dthm c
has only substance units: false
is: HMDB00079
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: CHEBI:27468
name: 5,6-dihydrothymine
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR GPDDA1
product: MODEL1310110047#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_0983eaff_ad23_46e8_8817_5dbf0751994a
is: SBO:0000252
constant: false
initial amount: NaN
is: O43292
name: GPAA1
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8733

metaR A MANASEly
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.24
is: SBO:0000176
name: alpha-mannosidase, lysosomal
reversible: false
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000

metaM c16dc e
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C23H42NO6 CHARGE: -1
is: SBO:0000247
name: Hexadecanedioic acid mono-L-carnitine ester
is: HMDB00712

http://identifiers.org/biomodels.db/MODEL1310110047#_f7f606b9_3b34_4b8b_9723_14955e5946b5
has only substance units: false
boundary condition: true
name: PRDX2
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:7001
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_5a0ece2e_7ead_4f6c_9bc6_92bf3b6012d5
boundary condition: true
is: O43286
constant: false
name: B4GALT5
has only substance units: false
is encoded by: hsa:9334
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_57565c4a_eac2_4b5e_bb87_d4841cf270f7
boundary condition: true
initial amount: NaN
name: AMPD2
is encoded by: hsa:271
is: B2RB47
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaM crtsl r
is: HMDB00063
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17650
is: SBO:0000247
name: cortisol
constant: false
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735

metaR r1585
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
reversible: true

metaM ksii core2 pre7 g
initial amount: NaN
is: HMDB00175
type: Species
is: C00130
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 7
notes: FORMULA: C67H108N5O51SX CHARGE: -2
has only substance units: false
constant: false

metaR r0013
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_aa9aaa15_dc24_42d7_adb1_a92578ae3a82
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:84720
name: PIGO
type: Species
is: SBO:0000252
initial concentration: NaN

metaM c16dc c
is: SBO:0000247
is: HMDB00712
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C23H42NO6 CHARGE: -1
name: Hexadecanedioic acid mono-L-carnitine ester
initial concentration: 1.0
constant: false

metaR TYR3MO2
type: Reaction
name: tyrosine 3-monooxygenase
notes: GENE_ASSOCIATION: (7054.1) or (7054.3) or (7054.2) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.16.2 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9920892 NOTES:SAB unlumped form based on PMID 10727395
modifier: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.14.16.2
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#

metaM ksi deg30 l
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
name: keratan sulfate I, degradation product 30

metaM vitd3 e
has only substance units: false
is: HMDB00876
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
constant: false
is: SBO:0000247
initial concentration: 1.0
name: calciol
is: CHEBI:28940
boundary condition: false
initial amount: NaN
type: Species

metaM hs deg25 l
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16126
notes: FORMULA: C23H37O21 CHARGE: -1
type: Species
initial amount: NaN
boundary condition: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_07c1f40e_6d36_42dd_b866_2480779c0d86
type: Species
constant: false
is encoded by: hsa:217
name: ALDH2
is: SBO:0000252
is: P05091
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_46a3badd_7378_43f2_8655_450d2f5473fb
initial concentration: NaN
is encoded by: hsa:7054
initial amount: NaN
type: Species
name: TH
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaR LEUGLYHYc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000134
reactant: MODEL1310110047#
name: hydrolysis of leucylglycine
is: SBO:0000176
fast: false
reversible: true
type: Reaction

metaM m3gacpail hs r
has only substance units: false
initial concentration: 1.0
is: CHEBI:16240
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
is: HMDB03125
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

metaR 2AMACSULT
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220,PMID:6351723 NOTES:-this is a lumped rxn w/ an inferred reduction rxn that occurs in conjunction w/ sulfotransferase step; this reduction step has to occur in order for the transformation (2amac-->Lcyst) to be valid -used NADPH as electron donor since it is a common cofactor involved in biosynthetic steps utilizing oxygen (see Neema for further explanations) MM
name: 2-Aminoacrylate sulfotransferase
type: Reaction

metaM pyr c
constant: false
is: HMDB00243
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:15361
name: pyruvate
is: C00022
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C3H3O3 CHARGE: -1
type: Species
initial amount: NaN

metaR FAOXC164C163x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_7070c679_c389_4fbc_bb19_ff865ff0480a
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:H45672
initial concentration: NaN
name: _H45672_1_m
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_54a50f77_c55f_49cf_8af4_828e59310b66
has only substance units: false
initial amount: NaN
type: Species
name: GLO1
constant: false
is: Q04760
is: SBO:0000252
is encoded by: hsa:2739
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_f02b0cc3_fdd8_4c9d_88e0_99531773001e
boundary condition: true
initial concentration: NaN
name: IDH2
is: P48735
type: Species
is encoded by: hsa:3418
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR FRDPtcr
is: SBO:0000185
reactant: MODEL1310110047#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
fast: false
reversible: true
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110047#_f49cc594_b868_4963_beeb_f02817d6aeda
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: C9JT23
name: NDUFA11
is encoded by: hsa:126328
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_5d64ebc9_1956_4501_b735_4df0f4b008a1
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2523
constant: false
initial concentration: NaN
boundary condition: true
name: FUT1
is: Q6IZA2
has only substance units: false

metaM sphgn c
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial concentration: 1.0
name: sphinganine(1+)
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57817
has only substance units: false
is: HMDB00269
constant: false

metaM malcoa r
is: CHEBI:57384
initial amount: NaN
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
constant: false
has only substance units: false
is: SBO:0000247
name: malonyl-CoA(4-)
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01175

metaM chsterol e
name: cholesterol
initial concentration: 1.0
is: HMDB00067
constant: false
boundary condition: false
is: CHEBI:16113
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR FAOXC183C163Gm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaR r1583
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM chsterol c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
constant: false
initial amount: NaN
name: cholesterol
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_ca5e4b09_8e6b_4f34_b4a1_a4e9271543ac
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:33
boundary condition: true
name: ACADL
is: SBO:0000252
is: P28330

metaR PTDCAt
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
fast: false
is: SBO:0000185
product: MODEL1310110047#
name: fatty acid transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_892f3988_44cf_4f8e_9fcb_ab874540bae1
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:27068
name: PPA2
initial amount: NaN

metaM hs deg7 l
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
constant: false
is: HMDB01352
is: CHEBI:17180
name: heparan sulfate, degradation product 7
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaM pail34p hs c
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57658
has only substance units: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM hxan e
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: hypoxanthine
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00157
initial concentration: 1.0
boundary condition: false
is: CHEBI:17368

http://identifiers.org/biomodels.db/MODEL1310110047#_030d80b4_9073_49cd_8369_ef3f1dd3f87b
is: SBO:0000252
is: O94788
is encoded by: hsa:8854
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: ALDH1A2

metaM m8mpdol U r
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:59093
boundary condition: false
initial amount: NaN
has only substance units: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110047#_5c22c828_081b_46a5_83e0_ff94a83cd398
is: SBO:0000252
is encoded by: hsa:3425
name: IDUA
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P35475
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_878ca342_aefe_469e_9d14_00810d49a4d5
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC12A4
type: Species
is encoded by: hsa:6560
boundary condition: true
is: F5H066
constant: false

metaM lgnccoa x
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
type: Species
name: lignocericyl coenzyme A
initial amount: NaN
is: HMDB06526
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_07534f9d_4e33_4dec_b790_2b27c4ab59b3
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:26
is: SBO:0000252
boundary condition: true
constant: false
name: ABP1
initial concentration: NaN
is: P19801

http://identifiers.org/biomodels.db/MODEL1310110047#_26a1bc51_08e6_4306_95bf_c79d265004b4
is: O95167
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: NDUFA3
is encoded by: hsa:4696
is: SBO:0000252

metaM occoa m
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
initial concentration: 1.0
is: HMDB01070
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57386
boundary condition: false
is: C01944

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:28940
has only substance units: false
type: Species
name: calciol
initial concentration: 1.0
is: HMDB00876

metaM glyc3p x
is: CHEBI:57597
initial amount: NaN
has only substance units: false
is: C00093
type: Species
boundary condition: false
name: Glycerol 3-phosphate
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126

metaR r1580
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110047#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#
is: SBO:0000185

metaM mgacpail hs r
is: CHEBI:7896
constant: false
is: HMDB00220
is: C00249
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
type: Species
initial concentration: 1.0
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false

metaM idp e
is: CHEBI:58280
type: Species
has only substance units: false
constant: false
is: HMDB03335
is: SBO:0000247
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_06c0b801_3ec6_4c31_93c7_ba3228877f1b
boundary condition: true
constant: false
is: SBO:0000252
name: COX2
type: Species
is: Q7GXZ8
is encoded by: hsa:4513
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM for r
boundary condition: false
name: Formate
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
is: HMDB00142
is: C00058

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaM galgalgalthcrm hs c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
type: Species
boundary condition: false
is: HMDB00143
constant: false
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_437c6c53_0d46_4434_8014_326fcbec168d
is encoded by: hsa:1892
is: SBO:0000252
boundary condition: true
constant: false
name: ECHS1
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: P30084

metaR KCCt
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true
is described by: ECO:0000269
name: K+-Cl- cotransport
reactant: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_98485b01_1251_4bd3_9dec_002fdce879ce
is encoded by: hsa:126
name: ADH1A:ADH1C
boundary condition: true
type: Species
has part: P00326
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000297
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_b1c5a6a7_7a40_449f_bdd1_20806a6543b5
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:1636
name: ACE
initial concentration: NaN
initial amount: NaN
is: B4DKH4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_c4686280_a01b_463b_89e2_f28c153c314f
name: DBT:DLD:BCKDHA:BCKDHB
boundary condition: true
has only substance units: false
is encoded by: hsa:594
type: Species
initial concentration: NaN
has part: P21953
is encoded by: hsa:593
has part: P11182
constant: false
is: SBO:0000297
has part: B4DP47
initial amount: NaN
is encoded by: hsa:1629

metaM ppp9 m
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:36159
has only substance units: false
name: Protoporphyrin
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
is: HMDB00241
is: SBO:0000247
initial concentration: 1.0

metaM fe3 e
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: HMDB12943
boundary condition: false
is: CHEBI:29034
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
has only substance units: false
is: SBO:0000247
name: Fe3+

http://identifiers.org/biomodels.db/MODEL1310110047#_25ffaeec_4995_4d87_8da2_3f23406562c7
is: SBO:0000252
is: Q8WWT9
boundary condition: true
name: SLC13A3
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:64849

metaM cs a deg5 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
boundary condition: false
notes: FORMULA: C23H36O24S CHARGE: -2
initial concentration: 1.0
is: CHEBI:15936
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_fa871721_1e4b_4d9f_a884_dea0144bc0c5
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q96QE2
boundary condition: true
constant: false
name: SLC2A13
is encoded by: hsa:114134
type: Species

metaR r1581
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110047#
fast: false

metaM CE2839 e
is: C01936
name: maltodecaose
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839

metaR SO4t4 2
reversible: true
fast: false
modifier: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
type: Reaction
name: sulfate transport via sodium symport
is described by: ECO:0000269
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110047#_e4aaeb80_6bb8_4c94_ac64_4ad9c3347f74
boundary condition: true
is: Q53Y41
is encoded by: hsa:1644
initial concentration: NaN
name: DDC
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR TETHEX3t
fast: false
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110047#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110047#
reversible: true

metaM cs e deg4 l
initial concentration: 1.0
is: HMDB00127
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H46NO38S4 CHARGE: -5
initial amount: NaN
is: CHEBI:15748
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4

metaR RE2987X
reactant: MODEL1310110047#
name: RE2987
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
reversible: true
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110047#

metaR S6TASE20ly
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110047#_3db5401e_87f3_4434_8d6b_3251fe87c033
type: Species
is: P83881
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6173
boundary condition: true
name: RPL36A
initial concentration: NaN

metaR FATP8t
modifier: MODEL1310110047#
name: fatty acid electroneutral transport
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110047#
type: Reaction

metaR r1821
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM galgalgalthcrm hs e
initial concentration: 1.0
is: SBO:0000247
is: C00124
is: HMDB00143
type: Species
constant: false
has only substance units: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
boundary condition: false
is: CHEBI:0
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
initial amount: NaN

metaR URIK1
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
type: Reaction
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.48
name: uridine kinase (ATP:Uridine)
is described by: ECO:0000269

metaR MANter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: mannose efflux from endoplasmic reticulum
type: Reaction

metaM idp c
type: Species
is: CHEBI:58280
constant: false
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_e0997818_4e10_472e_a47a_5421825798b9
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: AQP9
is: O43315
has only substance units: false
is encoded by: hsa:366
is: SBO:0000252

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR GLUt2m
reversible: true
product: MODEL1310110047#
name: L-glutamate reversible transport via proton symport, mitochondrial
kinetic law: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
modifier: MODEL1310110047#
type: Reaction
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000269

metaR M13N2Tg
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.101
is: SBO:0000176
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_5a3cbe49_6bb7_4b6a_a573_9d2651089467
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: B4DGD7
name: IDS
is encoded by: hsa:3423
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_74b7317e_6ddb_4182_90c6_c060b62a4550
type: Species
name: ACSS2
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: Q5QPH3
is encoded by: hsa:55902
boundary condition: true

metaM dhdascb c
boundary condition: false
is: HMDB01264
is: SBO:0000247
type: Species
initial amount: NaN
name: dehydroascorbide(1-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: CHEBI:58070
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_ca038fc9_b559_4a79_8881_0b3763527752
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1621
is: SBO:0000252
type: Species
name: DBH
constant: false
is: P09172

metaR LINKDEG1ly
product: MODEL1310110047#
name: degradation of proteoglycan linkage region, lysosomal
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is: SBO:0000176
fast: false
reactant: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaM duri n
initial concentration: 1.0
is: HMDB00012
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: 2'-deoxyuridine
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaR r1822
name: Y+LAT2 Utilized transport
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110047#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_85ee64a4_d300_4682_8fd8_a12fa158e234
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q6IBC4
type: Species
name: NDUFS6
is encoded by: hsa:4726

metaM fe3 c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: Fe CHARGE: 3
is: SBO:0000247
type: Species
boundary condition: false
name: Fe3+
constant: false
is: HMDB12943

http://identifiers.org/biomodels.db/MODEL1310110047#_bd45a052_269b_4f88_929a_0998b994fdda
is: SBO:0000252
is: E2QRH8
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5332
initial concentration: NaN
type: Species
name: PLCB4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_9374f201_0cf7_4d60_9c40_3dd93960cbbe
initial amount: NaN
is: SBO:0000252
constant: false
name: ENPP1
type: Species
boundary condition: true
is: P22413
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5167

http://identifiers.org/biomodels.db/MODEL1310110047#_0b74fae7_4040_483b_9ee1_5bd783074d4a
type: Species
constant: false
name: _AV717590_1_c
has only substance units: false
is encoded by: hsa:AV717590
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR NTP3e
modifier: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110047#
name: nucleoside-triphosphatase (GTP)
reversible: false
reactant: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:

metaR BTND1n
product: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.12
is described by: ECO:0000269
modifier: MODEL1310110047#
reversible: false
fast: false
reactant: MODEL1310110047#
type: Reaction
name: biotinidase (biotin), nuclear
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT

metaR DLNLCGt
product: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
name: fatty acid transport via diffusion
reversible: true
fast: false

metaM ksi deg8 l
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
boundary condition: false
name: keratan sulfate I, degradation product 8
initial concentration: 1.0
type: Species
is: CHEBI:12936
has only substance units: false
is: HMDB00143
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_0551a8f3_f27c_4db2_a9b5_2cde95acb293
is: SBO:0000252
constant: false
is encoded by: hsa:4548
is: Q99707
has only substance units: false
boundary condition: true
initial amount: NaN
name: MTR
type: Species
initial concentration: NaN

metaM glyald c
initial concentration: 1.0
is: C00577
is: SBO:0000247
is: HMDB01051
boundary condition: false
is: CHEBI:17378
has only substance units: false
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
type: Species
name: D-Glyceraldehyde
initial amount: NaN

metaR H2Oter
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110047#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: H2O endoplasmic reticulum transport
product: MODEL1310110047#
reactant: MODEL1310110047#

metaM tyr L m
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:17895
is: HMDB00158
name: L-tyrosine
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_ce5a1abc_a70a_4858_9397_38850408b903
is encoded by: hsa:3067
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: P19113
name: HDC
is: SBO:0000252
has only substance units: false

metaR ASNtN1
fast: false
reactant: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000185
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110047#

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR HSD17B42x
product: MODEL1310110047#
is: SBO:0000176
name: hydroxysteroid (17-beta) dehydrogenase 4
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#
fast: false

metaR HSAT2ly
reversible: false
type: Reaction
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110047#
is: SBO:0000185

metaM gullac c
is: CHEBI:17587
constant: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
type: Species
name: L-gulono-1,4-lactone
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB03466
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_63f696db_6215_452f_baf9_de99883df765
constant: false
is encoded by: hsa:4200
has only substance units: false
is: P23368
is: SBO:0000252
name: ME2
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR PHEt4
name: L-phenylalanine transport in via sodium symport
type: Reaction
reversible: false
kinetic law: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110047#_550ee57f_6e3e_4c94_b46f_d4a519942474
type: Species
name: DCXR
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:51181
initial concentration: NaN
is: SBO:0000252
is: Q7Z4W1
initial amount: NaN

metaM galgalgalthcrm hs g
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
initial concentration: 1.0
is: CHEBI:26174
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
boundary condition: false
type: Species
initial amount: NaN

metaR FAOXC1811602m
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
reversible: false
product: MODEL1310110047#
type: Reaction
fast: false
is: SBO:0000176

metaR r2113
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110047#

metaM i e
name: iodide
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382
is: HMDB12238
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR r0483
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reactant: MODEL1310110047#
type: Reaction
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_7a4a382f_a363_44df_8c4d_68021571d5b0
is encoded by: hsa:23464
initial amount: NaN
is: E2QC23
name: GCAT
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_55f8641a_fee5_463b_af96_738aee9380c0
initial concentration: NaN
initial amount: NaN
constant: false
name: NDUFA2
is encoded by: hsa:4695
is: O43678
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaM eitetcoa x
boundary condition: false
has only substance units: false
name: 5,8,11,14-eicosatetraenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR RE1523M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1523
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110047#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110047#_ed03faa9_c49b_4886_b21a_f52dd6b46c3a
initial amount: NaN
is encoded by: hsa:93034
boundary condition: true
constant: false
name: NT5C1B
is: SBO:0000252
is: Q96P26
type: Species
initial concentration: NaN
has only substance units: false

metaR NADS2
is: SBO:0000176
kinetic law: MODEL1310110047#
fast: false
name: NAD synthase (glutamine-hydrolysing)
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.1
type: Reaction

metaR ACACT7p
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110047#
product: MODEL1310110047#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction

metaM Ssq23epx r
initial concentration: 1.0
constant: false
name: (S)-2,3-epoxysqualene
has only substance units: false
boundary condition: false
is: HMDB01188
is: SBO:0000247
initial amount: NaN
is: CHEBI:15441
type: Species
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054

metaR HPDCACRNCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reactant: MODEL1310110047#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
fast: false
name: carnitine fatty-acyl transferase

metaR BAAT1x
modifier: MODEL1310110047#
name: bile acid Coenzyme A: amino acid N-acyltransferase
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
product: MODEL1310110047#
type: Reaction
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110047#_8803eba2_ff1a_4da0_a83f_31dd49767600
constant: false
name: _U37519_1_c
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:U37519
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaR r2112
modifier: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110047#
is: SBO:0000185

metaR FAOXC6C4x
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_4f58f505_8810_4c28_8ea2_eb704e8c9bc8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AI694761
has only substance units: false
initial amount: NaN
name: _AI694761_1_c

http://identifiers.org/biomodels.db/MODEL1310110047#_0b2faa83_3cf5_411f_a284_bfedd90cd542
is encoded by: hsa:123041
name: SLC24A4
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_5c3895ef_a196_4cba_9fe1_68285edd4930
initial concentration: NaN
is: F6SH78
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: ELOVL5
is: SBO:0000252
is encoded by: hsa:60481

metaM 4hglusa m
initial amount: NaN
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
boundary condition: false
name: L-4-hydroxyglutamic semialdehyde
is: SBO:0000247
is: HMDB06556
is: CHEBI:27809
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_7e7c0c2b_f9f0_4090_b4e8_4b18751d409c
is encoded by: hsa:10905
name: MAN1A2
type: Species
constant: false
is: O60476
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM 3odcoa x
is: CHEBI:28528
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3-Oxodecanoyl-CoA
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
has only substance units: false
is: HMDB03939
constant: false
boundary condition: false
type: Species

metaR FADH2ETC
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
name: Complex II reaction for respiratory chain
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaM ksii core2 pre6 g
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6

http://identifiers.org/biomodels.db/MODEL1310110047#_ac812913_7daa_4bff_bf2c_b28f3d3e8505
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:BE042354
initial amount: NaN
name: _BE042354_1_m
is: SBO:0000252

metaR FAOXC80
name: Beta oxidation of med/long chain fatty acid
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110047#
reversible: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_ec2fa4a1_2f47_4826_b0f8_2fbddc45cc84
boundary condition: true
initial concentration: NaN
is encoded by: hsa:204
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: AK2

metaR r2111
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_3a78f298_0723_4336_921b_92b54b10d51a
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:U37519
name: _U37519_1_m
is: SBO:0000252

metaM 2ddecdicoa m
constant: false
is: HMDB11123
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 2,6-dodecadienoylcoa
type: Species
initial concentration: 1.0
has only substance units: false
is: C05279
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110047#_78ed3fd6_4e7a_4e47_9ab2_539da9a440b8
is encoded by: hsa:3242
initial concentration: NaN
type: Species
boundary condition: true
name: HPD
has only substance units: false
constant: false
is: SBO:0000252
is: B3KQ63
initial amount: NaN

metaM cs b l
type: Species
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
is: HMDB02183
initial concentration: 1.0
is: CHEBI:36005
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: SBO:0000247

metaM pail4p hs c
is: CHEBI:58178
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false

metaR IDOAASE3ly
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.76
modifier: MODEL1310110047#
product: MODEL1310110047#
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110047#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction

metaM leuktrA4 e
has only substance units: false
name: leukotriene A4(1-)
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_26f29938_a312_4127_ac80_c902d3cbc9de
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23498
constant: false
name: HAAO
is: P46952

metaM core4 g
constant: false
initial concentration: 1.0
boundary condition: false
name: Core 4
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0

metaM for e
name: formate
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:15740
has only substance units: false

metaR G14T19g
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM hcys L c
initial concentration: 1.0
constant: false
is: CHEBI:17588
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
name: L-homocysteine
has only substance units: false
is: HMDB00742
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r2110
product: MODEL1310110047#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM 3hpcoa m
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB06807
initial concentration: 1.0
constant: false
is: CHEBI:58528
name: 3-hydroxypropanoyl-CoA(4-)
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668

metaR r0480
reversible: true
type: Reaction
product: MODEL1310110047#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110047#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_3632c601_5763_43c2_93af_6a9ffec6150c
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: Q96C36
type: Species
is: SBO:0000252
name: PYCR2
initial amount: NaN
is encoded by: hsa:29920

metaM clpn hs c
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:28494
has only substance units: false
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
boundary condition: false
name: cardiolipin

http://identifiers.org/biomodels.db/MODEL1310110047#_ea30076d_fa29_478d_b96e_b577edcb2062
has only substance units: false
is encoded by: hsa:26227
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: PHGDH
is: O43175
initial concentration: NaN
boundary condition: true

metaR SPODMm
type: Reaction
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
name: superoxide dismutase
reversible: false
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000304
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110047#

metaM ach c
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00895
initial amount: NaN
has only substance units: false
name: acetylcholine
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_6d6cba1e_5718_46f1_b3d3_ded3157e7a20
is encoded by: hsa:53
boundary condition: true
constant: false
initial concentration: NaN
name: ACP2
is: E9PCI1
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR r2117
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185

metaR C10DCCACT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR G5SADrm
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
is described by: ECO:0000000
product: MODEL1310110047#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reactant: MODEL1310110047#

metaR C161CRN2t
name: C161 transport into the mitochondria
product: MODEL1310110047#
fast: false
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185

metaM gchola x
has only substance units: false
is: HMDB00138
is: CHEBI:58235
initial amount: NaN
type: Species
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
name: glycocholate
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_512a5f56_3956_44b7_99d9_c3ad8488574a
name: ITPKC
type: Species
is: Q96DU7
initial concentration: NaN
is encoded by: hsa:80271
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_ba42dcbf_a07b_4192_b96d_adf0d871b5fe
is encoded by: hsa:4702
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: B1AM93
type: Species
name: NDUFA8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_a0503602_88ed_431d_9034_c27b515d9c95
is: Q9UJ70
constant: false
is encoded by: hsa:55577
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: NAGK
has only substance units: false
initial amount: NaN

metaM txa2 r
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
type: Species
is: HMDB01452
is: CHEBI:57445
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: thromboxane A2(1-)

metaR RE2972M
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
reversible: true
product: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.67
name: RE2972
is described by: ECO:0000000
modifier: MODEL1310110047#
type: Reaction
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

metaM idp n
is: HMDB03335
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58280
is: SBO:0000247
constant: false
type: Species
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
boundary condition: false

metaR SPODMn
reversible: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
name: superoxide dismutase, nuclear
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110047#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1

http://identifiers.org/biomodels.db/MODEL1310110047#_2f2aaed1_0b1a_446f_8a7e_562497841b9d
initial amount: NaN
boundary condition: true
is: Q86YI5
name: DLAT
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1737
has only substance units: false

metaM retn r
is: CHEBI:35291
name: all-trans-retinoate
type: Species
boundary condition: false
is: HMDB01852
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
is: SBO:0000247

metaR r2116
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110047#
reversible: true
fast: false
type: Reaction
product: MODEL1310110047#

metaM malcoa c
is: HMDB01175
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: C00083
name: Malonyl-CoA
is: CHEBI:57384

metaM hxan c
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00157
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0
name: Hypoxanthine
is: CHEBI:17368
is: C00262
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_d9ff4321_24e4_4c7b_9f8c_0622f1d9f5f7
is: Q9NRA2
is encoded by: hsa:26503
name: SLC17A5
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaR SERCYSNaEx
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000269
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
modifier: MODEL1310110047#
type: Reaction
reversible: false
reactant: MODEL1310110047#

metaM gdp m
is: SBO:0000247
constant: false
initial amount: NaN
name: GDP
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01201
is: CHEBI:58189
is: C00035

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_c9728123_385a_4047_a057_6e5618f662ae
name: UROD
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7389
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: P06132

metaM ach e
boundary condition: false
initial concentration: 1.0
is: HMDB00895
initial amount: NaN
is: CHEBI:15355
is: SBO:0000247
name: acetylcholine
type: Species
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false

metaR ADKd
product: MODEL1310110047#
type: Reaction
name: adenylate kinase (d form)
reversible: true
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
modifier: MODEL1310110047#
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

metaR SEBCOAPET
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ba21a781_1c9f_4e3e_b6bc_44097ca4695e
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q92835
constant: false
is encoded by: hsa:3635
initial concentration: NaN
name: INPP5D

metaM i c
name: iodide
is: SBO:0000247
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16382
is: HMDB12238
initial amount: NaN

metaM glyc3p m
name: Glycerol 3-phosphate
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
initial amount: NaN
has only substance units: false
constant: false
is: C00093
initial concentration: 1.0
boundary condition: false
is: HMDB00126
is: SBO:0000247

metaM tchola c
type: Species
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
has only substance units: false
initial amount: NaN
name: taurocholic acid
is: CHEBI:36257
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false

metaR r2115
product: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_b854c182_6b48_4462_b26a_5b24cabb9317
is: SBO:0000252
initial amount: NaN
name: SLC24A2
is: Q9UI40
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:25769

metaM duri e
is: C00526
constant: false
is: CHEBI:16450
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
initial concentration: 1.0
name: Deoxyuridine
type: Species

metaM mmcoa R m
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
name: (R)-methylmalonyl-CoA(5-)
is: HMDB01269
type: Species
has only substance units: false
is: CHEBI:57326

metaR MANt1r
name: mannose transport (uniport)
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000269
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
reactant: MODEL1310110047#
is: SBO:0000185
modifier: MODEL1310110047#
reversible: true

metaM gdp n
boundary condition: false
is: HMDB01201
is: CHEBI:58189
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR NACHEX17ly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is: SBO:0000176
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110047#_0f00e6b2_f0a8_40a4_b4a0_5446d71e7beb
initial amount: NaN
name: UCK2
constant: false
is: Q9BZX2
type: Species
has only substance units: false
is encoded by: hsa:7371
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR PACCOAL
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110047#
fast: false
name: phenylacetate-CoA ligase
reversible: false

metaR GUMGCHLe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR GMPtg
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
name: GMP transport (Golgi)
is: SBO:0000185
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reactant: MODEL1310110047#

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR FAOXC17C15m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaR CYSGLTH
reversible: true
name: Glutathione:cystine oxidoreductase
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
type: Reaction

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR CYSSERNaEx
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
reversible: false
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110047#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110047#_f39ebac6_b5e5_4780_9709_57e89948efb1
has only substance units: false
constant: false
is: P54709
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:483
name: ATP1B3
boundary condition: true

metaR r2114
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
fast: false

metaR r1692
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185

metaR M4MPDOL Uter
fast: false
kinetic law: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: m4mpdol flippase
is: SBO:0000185
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_b2d2297e_f453_44b3_824d_927cfb7034a3
is encoded by: hsa:65263
has only substance units: false
name: PYCRL
is: Q53H96
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR FAOXTC102C101m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaR CHOLPtg
type: Reaction
name: choline phosphate intracellular transport
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
product: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_9ccfd403_f5d1_4761_bc90_4f0e74209a89
is: SBO:0000252
type: Species
boundary condition: true
name: _7359_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:7359

metaR r2534
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
reactant: MODEL1310110047#
is: SBO:0000185

metaM retinol cis 11 e
initial concentration: 1.0
is: HMDB06216
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
has only substance units: false
name: 11-cis-retinol
boundary condition: false
is: SBO:0000247
is: CHEBI:16302
initial amount: NaN
constant: false

metaM CE5121 m
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57449
boundary condition: false
is: SBO:0000247
name: trans-3-decenoyl-CoA
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121

metaM c81coa c
is: C05276
is: SBO:0000247
boundary condition: false
is: HMDB03949
name: octenoylcoa
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaR GDPtg
is: SBO:0000185
name: GDP intracellular transport
type: Reaction
product: MODEL1310110047#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_e473f5ee_e178_42b2_be1b_d5a54fe41862
type: Species
initial amount: NaN
is encoded by: hsa:622
has only substance units: false
name: BDH1
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_463ecdbd_c702_4b62_9a75_844577101b0e
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:51809
name: GALNT7
initial amount: NaN
initial concentration: NaN
is: Q86SF2

http://identifiers.org/biomodels.db/MODEL1310110047#_e3ed6ec3_eaab_40ad_8d9c_682a299b7d69
is: SBO:0000252
is encoded by: hsa:5498
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P50336
type: Species
constant: false
boundary condition: true
name: PPOX

http://identifiers.org/biomodels.db/MODEL1310110047#_9ba870af_d043_4bce_9fda_b35dfb52d827
has only substance units: false
name: MTMR3
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:8897
is: SBO:0000252
type: Species
constant: false

metaM sl L e
initial concentration: 1.0
name: (S)-3-sulfonatolactate(2-)
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
has only substance units: false
is: CHEBI:61289

metaR NDPK5n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000304
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaR r2535
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110047#

metaR r0339
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
reversible: false
modifier: MODEL1310110047#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31

metaR FAOXC185C164m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaM 7thf e
name: heptaglutamyl folate (THF)
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB06559
type: Species
notes: FORMULA: C49H57N13O24 CHARGE: -8

metaM 2ddecdicoa x
name: 2,6-dodecadienoylcoa
has only substance units: false
is: HMDB11123
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
is: C05279
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_d5852639_ae53_46b7_a6ba_c22d26bb25df
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ELOVL4
boundary condition: true
constant: false
initial amount: NaN
is: Q9GZR5
type: Species
is encoded by: hsa:6785

metaR HMGCOARc
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
kinetic law: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000134
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaM pail4p hs n
initial amount: NaN
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: CHEBI:58178
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_f4db848a_4138_4ded_bcb4_024e421a1fe2
initial concentration: NaN
initial amount: NaN
is: H7C5B8
is encoded by: hsa:4708
name: NDUFB2
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaM am6sa c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H7NO3 CHARGE: 0 INCHI: InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10)/p-1/b2-1-,5-3+ HEPATONET_1.0_ABBREVIATION: HC01186 EHMN_ABBREVIATION: C03824
is: CHEBI:57495
boundary condition: false
initial concentration: 1.0
is: HMDB01280
type: Species
constant: false
has only substance units: false
name: 2-aminomuconate 6-semialdehyde(1-)

http://identifiers.org/biomodels.db/MODEL1310110047#_8b9b8bd3_069b_4186_bb47_495484c31f7f
is encoded by: hsa:5145
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: PDE6A
constant: false
is: P16499

metaM acald e
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
name: acetaldehyde
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:15343
has only substance units: false
is: HMDB00990
is: SBO:0000247
initial amount: NaN

metaR MANt4
name: D-mannose transport via sodium cotransport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
product: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110047#

metaM leuktrD4 e
constant: false
name: Leukotriene D4
type: Species
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
is: CHEBI:28666
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB03080

metaM urea m
has only substance units: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial amount: NaN
type: Species
constant: false
is: C00086
is: HMDB00294
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16199
name: Urea
boundary condition: false

metaM dmhptcoa m
constant: false
is: HMDB06258
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 2,6 dimethylheptanoyl-CoA

metaR UROLACer
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
kinetic law: MODEL1310110047#
name: uronolactonase, endoplasmic reticulum
product: MODEL1310110047#
fast: false
reversible: true
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000176

metaR XYLTD Dr
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
product: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
name: xylitol dehydrogenase (D-xyulose-forming)
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reversible: true

metaR r2388
product: MODEL1310110047#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: false
modifier: MODEL1310110047#

metaR PROIMINOtc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Proline by the apical IMINO amino acid transporters in kidney and intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_cbe0dabf_9b73_4221_9e92_e61fc6361b24
is encoded by: hsa:4716
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: A8K761
is: SBO:0000252
has only substance units: false
name: NDUFB10

metaM gal l
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: D-galactose
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: HMDB00143
type: Species
initial concentration: 1.0

metaM glx c
initial amount: NaN
name: glyoxylate
has only substance units: false
boundary condition: false
is: HMDB00119
is: CHEBI:36655
is: SBO:0000247
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110047#_92cb925c_deb7_420a_84c6_f9bab82198b2
is: SBO:0000252
is encoded by: hsa:6648
boundary condition: true
constant: false
has only substance units: false
name: SOD2
initial amount: NaN
is: P04179
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_46aaea28_1e01_4d79_9adc_7a91c6580ffd
is encoded by: hsa:1717
is: Q9UBM7
initial amount: NaN
constant: false
name: DHCR7
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR RE3242R
kinetic law: MODEL1310110047#
name: RE3242
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110047#
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000
product: MODEL1310110047#

metaR r2118
reactant: MODEL1310110047#
reversible: true
modifier: MODEL1310110047#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110047#_567bb4b9_581b_48b0_a63e_934aac208f7f
is: Q76EJ3
name: SLC35D2
is encoded by: hsa:11046
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_92868e52_91e3_4e91_8874_188b366f7221
is: SBO:0000252
initial concentration: NaN
name: ALDH3B2
type: Species
is: P48448
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:222

http://identifiers.org/biomodels.db/MODEL1310110047#_6d7ec67e_0eb2_4190_8da5_fe94a98f7d0d
is: E7EPT3
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ALDH7A1
constant: false
is encoded by: hsa:501
is: SBO:0000252
type: Species
has only substance units: false

metaR FACOAL1831
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000269
kinetic law: MODEL1310110047#
reversible: true
name: fatty-acid--CoA ligase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110047#

metaM sl L c
is: CHEBI:61289
initial concentration: 1.0
name: (S)-3-sulfonatolactate(2-)
boundary condition: false
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species

metaR GLB1
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
name: Beta-galactosidase
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
type: Reaction
modifier: MODEL1310110047#

metaR FADtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: FAD transporter, peroxisomal
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
fast: false
reversible: true

metaR r2389
reactant: MODEL1310110047#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
type: Reaction
fast: false
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110047#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

metaR MAN6PI
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110047#
name: mannose-6-phosphate isomerase
reactant: MODEL1310110047#
is described by: ECO:0000304

metaM CE5118 m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: CHEBI:57923

metaR CYTK5n
kinetic law: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000269
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:

metaR r2537
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Utilized transport
is: SBO:0000185
reactant: MODEL1310110047#
product: MODEL1310110047#

metaR r2119
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110047#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110047#
reversible: true
product: MODEL1310110047#
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_27fdeb65_a06a_4a2f_927b_11b8891b27b2
name: FUCA1
is: P04066
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2517
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_0e5675be_1278_4022_9d42_705013671b34
initial amount: NaN
name: _AI971036_1_x
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:AI971036
is: SBO:0000252

metaR FACOAL1832
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
is described by: ECO:0000269
modifier: MODEL1310110047#
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110047#
is: SBO:0000176

metaR AG13T15g
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110047#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_39a7f5b3_9b4a_4c89_874c_323f81f0c702
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: PIGW
is encoded by: hsa:284098
initial amount: NaN
type: Species
is: Q7Z7B1
has only substance units: false

metaM succoa c
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: HMDB01022
has only substance units: false
name: Succinyl-CoA
initial concentration: 1.0

metaR STCOAtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110047#
name: fatty acid intracellular transport
reactant: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110047#

metaR HPDCAt
type: Reaction
fast: false
name: fatty acid transport via diffusion
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_5dec5dc8_d358_4042_bdba_4a6ba756695a
initial concentration: NaN
name: ACSS2
is: SBO:0000252
is: Q5QPH3
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:55902
type: Species

metaR DNDPt35m
name: dGDP transport via dADP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000185
fast: false
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reactant: MODEL1310110047#

metaR XYLtly
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
name: Xylose efflux from lysosome

metaR B3GNT36g
reactant: MODEL1310110047#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000176

metaM for c
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB00142
is: C00058
has only substance units: false
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
is: SBO:0000247
name: Formate

metaM leuktrD4 c
is: CHEBI:28666
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: Leukotriene D4
initial amount: NaN

metaR H2Otg
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
name: H2O transport, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM thyox L c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00248
is: CHEBI:18332
name: L-thyroxine
type: Species

metaM fadh2 x
is: SBO:0000247
is: CHEBI:58307
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: FADH2(2-)
is: HMDB01197
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_c6b46b97_3711_4606_b840_12c888b52361
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: SLC8A3
is encoded by: hsa:6547
type: Species
has only substance units: false

metaM ksii core2 pre10 g
initial concentration: 1.0
type: Species
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 10
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
initial amount: NaN
boundary condition: false
constant: false

metaM chsterol r
is: CHEBI:16113
boundary condition: false
is: HMDB00067
type: Species
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

metaR DM anth
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_4a8b0e9c_bca5_4ec2_8095_5cc6b1477084
has only substance units: false
is encoded by: hsa:3176
boundary condition: true
constant: false
name: HNMT
initial concentration: NaN
is: SBO:0000252
is: P50135
type: Species
initial amount: NaN

metaR OCTDECCACT
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM 12ppd S c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: CHEBI:29002
initial amount: NaN
type: Species
name: (S)-propane-1,2-diol
is: HMDB06213
boundary condition: false
is: SBO:0000247
constant: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR ACACt2m
type: Reaction
name: Acetoacetate mitochondrial transport via H+ symport
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reversible: true
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_9d144e67_43f6_474a_a0cd_00f5b7e0f197
constant: false
is encoded by: hsa:5152
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: PDE9A
has only substance units: false
initial amount: NaN

metaM 3ttetddcoacrn c
is: SBO:0000247
initial amount: NaN
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial concentration: 1.0
notes: FORMULA: C21H37NO5 CHARGE: 0
type: Species
has only substance units: false
constant: false
boundary condition: false
is: HMDB02014

metaR r1156
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
kinetic law: MODEL1310110047#
is: SBO:0000176
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#

metaR PMTCOAFABP1tc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of palmitoyl coA into the enterocytes
type: Reaction

metaR FACOAL161
product: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
name: fatty-acid--CoA ligase (hexadecenoate)
is: SBO:0000176
modifier: MODEL1310110047#
reversible: true
kinetic law: MODEL1310110047#
fast: false

metaM ahcys m
is: CHEBI:16680
initial concentration: 1.0
is: C00021
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00939
has only substance units: false
constant: false
initial amount: NaN

metaR r0488
reactant: MODEL1310110047#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_de3597ed_6e28_4157_b2a5_27ecbfd20bc9
initial concentration: NaN
has only substance units: false
is encoded by: hsa:80724
name: ACAD10
type: Species
is: SBO:0000252
is: G3XAJ0
constant: false
initial amount: NaN
boundary condition: true

metaR FAOXC12DCTc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaR r2532
is: SBO:0000185
kinetic law: MODEL1310110047#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#
type: Reaction

metaM gluala e
boundary condition: false
initial amount: NaN
name: 5-L-Glutamyl-L-alanine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/6503
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: HMDB06248
is: C03740

http://identifiers.org/biomodels.db/MODEL1310110047#_a9cda812_1c0e_4fe7_8ce8_3c4ebc630fcb
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AD000092_1_c
type: Species
is encoded by: hsa:AD000092
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_32064c27_5cec_4efb_b3e6_5107c3702edf
initial amount: NaN
type: Species
name: CHST5
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:23563
is: Q9GZS9
has only substance units: false
boundary condition: true

metaM ksi pre13 g
type: Species
has only substance units: false
constant: false
is: C00130
boundary condition: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 13
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
initial amount: NaN
is: CHEBI:58053

metaM thyox L e
initial concentration: 1.0
is: CHEBI:18332
name: L-thyroxine
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00248
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849

metaM lgnccoa c
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
name: lignocericyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
constant: false
is: HMDB06526

metaM ptrc m
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H14N2 CHARGE: 2 INCHI: InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2/p+2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 1,4-butanediammonium
is: CHEBI:326268
is: HMDB01414
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_c3b9f204_ecfb_494a_9ecd_b509f54a18b4
constant: false
has only substance units: false
name: ACADM
is encoded by: hsa:34
is: P11310
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaM glyc3p c
initial concentration: 1.0
constant: false
name: Glycerol 3-phosphate
is: HMDB00126
is: CHEBI:57597
is: C00093
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

metaM 3odcoa m
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28528
type: Species
is: HMDB03939
has only substance units: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
boundary condition: false
name: 3-Oxodecanoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_7130127b_8471_4847_8a07_07285f4f42b1
initial concentration: NaN
constant: false
name: UPP1
is encoded by: hsa:7378
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_c455b191_2da6_42ae_8387_22a0148f484d
type: Species
is: Q9NT06
constant: false
name: HMGCLL1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:54511
boundary condition: true
initial concentration: NaN

metaR r1154
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
is: SBO:0000176
reversible: true
name: EC:1.2.7.2
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_6341e97e_682e_4a20_a09b_d53aad901bfb
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: P24752
is encoded by: hsa:38
constant: false
initial concentration: NaN
initial amount: NaN
name: ACAT1

metaM 3ttetddcoacrn e
initial amount: NaN
is: HMDB02014
boundary condition: false
has only substance units: false
notes: FORMULA: C21H37NO5 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: 3-hydroxy trans5,8tetradecadienoyl carnitine

metaR FAOXC1811601m
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
kinetic law: MODEL1310110047#
name: Beta oxidation fatty acid
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110047#
reversible: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110047#
type: Reaction
is: SBO:0000176

metaM ach n
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
is: HMDB00895
initial concentration: 1.0
boundary condition: false
type: Species
name: acetylcholine
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_9c099242_6468_499d_a8d7_57d31547bdd6
boundary condition: true
has only substance units: false
is: P13995
is encoded by: hsa:10797
constant: false
initial concentration: NaN
name: MTHFD2
initial amount: NaN
is: SBO:0000252
type: Species

metaR HPDCACRNCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110047#
is described by: ECO:0000000
product: MODEL1310110047#
reversible: false
name: heptadecanoate transport into the mitochondria
fast: false
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176

metaR GLCAASE7ly
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
reactant: MODEL1310110047#
name: beta-glucuronidase, lysosomal
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
type: Reaction

metaM 25aics c
is: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00797
is: CHEBI:58443
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
has only substance units: false

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

metaR EX c5dc
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_a64f93b2_8934_46f5_8a61_04fb3e9cf5da
is encoded by: hsa:8611
name: PPAP2A
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: G3XA95
initial concentration: NaN
type: Species

metaR RE3079X
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
modifier: MODEL1310110047#
reversible: true
name: RE3079
type: Reaction
is described by: ECO:0000000

metaR CYSGLYexR
is described by: ECO:0000000
type: Reaction
name: L-cysteine/glycine reversible exchanger
reversible: true
fast: false
product: MODEL1310110047#
is: SBO:0000185
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#

metaM m5mpdol U r
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
boundary condition: false
is: CHEBI:37634
constant: false

metaR FACOAL181i
is described by: ECO:0000269
fast: false
name: C181 fatty acid activation
kinetic law: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#

metaM retn e
constant: false
is: CHEBI:35291
name: all-trans-retinoate
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01852
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
has only substance units: false

metaM urea c
has only substance units: false
initial amount: NaN
is: HMDB00294
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16199
type: Species
name: Urea
boundary condition: false
is: C00086
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_d0eb3fb8_7dea_4bc5_905e_424882ea6b79
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI656480
name: _AI656480_1_m
has only substance units: false
type: Species

metaM adrncoa x
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
name: adrenyl coenzyme A
is: C16170

metaM ksi pre9 g
is: SBO:0000247
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
initial amount: NaN
is: C00130
constant: false
name: keratan sulfate I biosynthesis, precursor 9
type: Species
is: CHEBI:58053
initial concentration: 1.0
has only substance units: false
is: HMDB00175
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_9015710b_08b2_41c4_96be_1f26630a073b
is encoded by: hsa:131669
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: UROC1
boundary condition: true
is: Q68CJ7

http://identifiers.org/biomodels.db/MODEL1310110047#_f732fa46_8388_474d_b115_03b2aadab5c1
is: Q15392
boundary condition: true
is encoded by: hsa:1718
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: DHCR24
initial concentration: NaN

metaR r2382
is described by: ECO:0000000
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110047#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110047#
product: MODEL1310110047#

metaR FUT15g
is: SBO:0000176
modifier: MODEL1310110047#
product: MODEL1310110047#
fast: false
reversible: false
kinetic law: MODEL1310110047#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.69
name: Galactoside 2-alpha-L-fucosyltransferase 1
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reactant: MODEL1310110047#
type: Reaction

metaR PPAt
reactant: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is: SBO:0000185
name: Propionate transport, diffusion
fast: false
reversible: false
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_ebacd4ca_ff1a_4d6e_bb4a_1b72ec324b50
constant: false
name: ALPPL2
boundary condition: true
is: SBO:0000252
is: P10696
has only substance units: false
initial amount: NaN
is encoded by: hsa:251
initial concentration: NaN
type: Species

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_78fe6c2b_67f6_4cf7_9049_86d50c2b7ea8
initial amount: NaN
is: P14618
initial concentration: NaN
is encoded by: hsa:5315
boundary condition: true
constant: false
type: Species
name: PKM2
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_6b178a63_83dc_4dd9_9033_718429369501
is: SBO:0000252
constant: false
is: Q13057
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80347
name: COASY
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_fcf777e0_4762_472b_88ff_e96a33facd3b
boundary condition: true
is encoded by: hsa:LOC374569
type: Species
constant: false
name: _LOC374569_1_e
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r0732
reversible: false
fast: false
reactant: MODEL1310110047#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110047#

metaM oagd3 hs e
boundary condition: false
initial concentration: 1.0
is: HMDB02168
constant: false
is: SBO:0000247
name: 9-O-Acetylated GD3
has only substance units: false
is: CHEBI:18421
initial amount: NaN
type: Species
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110047#_6578609e_23ad_48f6_8c9b_4356c5e6c2ee
is encoded by: hsa:115286
constant: false
is: F8WAB8
name: SLC25A26
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR r1831
is: SBO:0000185
reversible: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110047#

metaR ITPtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110047#
reversible: true
fast: false
product: MODEL1310110047#
type: Reaction
name: ITP nuclear transport
reactant: MODEL1310110047#
is described by: ECO:0000000

metaM 5aizc c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: C04751
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:58564
is: HMDB06273
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_0826af90_0b67_4603_8b30_dc782bbb8bcd
is: Q9BZM2
name: PLA2G2F
constant: false
is encoded by: hsa:64600
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaR FAOXC205C185m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM occoa c
is: CHEBI:57386
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
is: SBO:0000247
is: HMDB01070
type: Species
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

metaR OCOAT1m
reversible: true
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.8.3.5
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
kinetic law: MODEL1310110047#
name: 3-oxoacid CoA-transferase
is described by: ECO:0000269

metaR VALTA
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110047#
is described by: ECO:0000269
modifier: MODEL1310110047#
fast: false
type: Reaction
reversible: true
name: valine transaminase
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
product: MODEL1310110047#

metaM HC02217 e
has only substance units: false
is: SBO:0000247
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
name: prostaglandin-g2
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species

metaR r0733
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110047#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110047#

metaM chsterol l
is: CHEBI:16113
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
boundary condition: false
is: HMDB00067
type: Species
initial amount: NaN
has only substance units: false
name: cholesterol

metaR r1830
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaR HEXCOAACBP
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM ahcys r
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
constant: false
is: HMDB00939
boundary condition: false
initial concentration: 1.0
is: CHEBI:16680
has only substance units: false
type: Species
is: SBO:0000247
name: S-adenosyl-L-homocysteine

metaM urea e
initial amount: NaN
is: HMDB00294
has only substance units: false
is: SBO:0000247
is: CHEBI:16199
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
type: Species
initial concentration: 1.0
name: Urea
constant: false
is: C00086
boundary condition: false

metaR TYRt
name: L-tyrosine transport
reversible: true
modifier: MODEL1310110047#
type: Reaction
is: SBO:0000185
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_c3362d44_6318_4ad3_b265_ced7bbe9ed43
name: MTMR3
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:8897
is: SBO:0000252
is: Q13615

http://identifiers.org/biomodels.db/MODEL1310110047#_de581086_0e5c_4ea4_bdcc_1b02bed3cfa2
constant: false
is: O75610
name: LEFTY1
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:10637
initial concentration: NaN

metaR RE2799C
is: SBO:0000176
type: Reaction
name: RE2799
product: MODEL1310110047#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
kinetic law: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#

metaR r2380
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_67b23abc_4984_4671_8967_90b596c45b89
is: P28845
is encoded by: hsa:3290
is: SBO:0000252
name: HSD11B1
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR r0734
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_5775ffdc_bb96_499c_b4ac_06bdac406e71
initial concentration: NaN
is encoded by: hsa:5168
is: Q13822
name: ENPP2
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_ccb077bf_0f94_43b1_b89c_3e49a1857f77
has only substance units: false
type: Species
is encoded by: hsa:43
boundary condition: true
name: ACHE
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110047#_037556d1_f2ea_47b5_bcf2_70c4a0f7c83f
constant: false
type: Species
is encoded by: hsa:217
boundary condition: true
name: ALDH2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P05091

metaR GALACGLCGALGBSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
name: galacglcgalgbside hs intracellular transport
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110047#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_fa17ffed_254c_4115_8a47_2a09f9ac36ea
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q12882
constant: false
name: DPYD
is encoded by: hsa:1806
is: SBO:0000252

metaM ddcacoa m
is: SBO:0000247
initial amount: NaN
is: HMDB03571
has only substance units: false
is: C01832
is: CHEBI:57375
boundary condition: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false

metaM chsterol m
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
constant: false
is: CHEBI:16113
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_e815a45a_4a7d_4ef8_9c87_0459744067c7
type: Species
is: O00400
has only substance units: false
name: SLC33A1
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:9197
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_351ca52b_5cee_4ce7_8b9b_e3cd7a42db6f
boundary condition: true
initial amount: NaN
is: F5H2Y9
is encoded by: hsa:8854
name: ALDH1A2
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaM oagd3 hs g
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: CHEBI:17315
name: 9-O-Acetylated GD3
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00329
is: SBO:0000247
is: HMDB01514
boundary condition: false
constant: false

metaM glu L e
has only substance units: false
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
initial concentration: 1.0
name: L-glutamate(1-)
boundary condition: false
initial amount: NaN
is: HMDB00148
constant: false
type: Species

metaM ttdcrn m
constant: false
is: http://identifiers.org/pubchem.compound/3413344
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
initial concentration: 1.0
is: HMDB05066
name: tetradecanoyl carnitine

metaR r1150
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is: SBO:0000185
name: Facilitated diffusion
is described by: ECO:0000000
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
type: Reaction

metaR DINt
type: Reaction
kinetic law: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
name: deoxyinosine transport via diffusion

metaM 5forthf c
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
constant: false
type: Species
is: CHEBI:57456
initial concentration: 1.0
is: HMDB01534
is: SBO:0000247
is: C00664
has only substance units: false
boundary condition: false
initial amount: NaN
name: 5-Formiminotetrahydrofolate

metaR r0735
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
modifier: MODEL1310110047#

metaR SPODMx
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110047#
name: superoxide dismutase, peroxisome
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110047#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110047#
modifier: MODEL1310110047#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_932d748e_1383_4751_8297_67cc1ff8c2ba
initial amount: NaN
has only substance units: false
has part: Q5VYT2
is: SBO:0000297
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4712
is encoded by: hsa:4731
initial concentration: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3

metaM gullac r
has only substance units: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
type: Species
constant: false
initial amount: NaN
name: L-gulono-1,4-lactone
is: SBO:0000247
is: HMDB03466
initial concentration: 1.0
is: CHEBI:17587
boundary condition: false

metaM HC02217 c
initial amount: NaN
has only substance units: false
is: CHEBI:27647
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247
boundary condition: false
name: prostaglandin-g2

http://identifiers.org/biomodels.db/MODEL1310110047#_cece3a4b_b964_4f3d_90e3_958ca9cec840
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:570
has only substance units: false
is: SBO:0000252
name: BAAT
type: Species
boundary condition: true
is: Q14032
constant: false

metaM acald c
constant: false
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
name: acetaldehyde
type: Species
initial concentration: 1.0
is: CHEBI:15343
is: SBO:0000247
is: HMDB00990
boundary condition: false

metaM nrvnc c
is: SBO:0000247
is: HMDB02368
boundary condition: false
constant: false
initial concentration: 1.0
name: nervonate
type: Species
has only substance units: false
is: CHEBI:32392
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial amount: NaN

metaR RE3381E
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
reversible: true
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110047#
name: RE3381

http://identifiers.org/biomodels.db/MODEL1310110047#_d384f50a_57b0_4a85_bbac_510c3c0c8e5c
initial amount: NaN
is: SBO:0000252
name: _T83654_1_m
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:T83654
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_92590f92_b553_491a_9058_b0d2b4dd6663
is encoded by: hsa:55512
is: SBO:0000252
initial amount: NaN
name: SMPD3
constant: false
is: A8K0T6
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR r2538
reactant: MODEL1310110047#
name: Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_317f9d17_4436_42ed_b798_64db5e1aa12a
name: ACP2
initial concentration: NaN
type: Species
initial amount: NaN
is: E9PCI1
is: SBO:0000252
is encoded by: hsa:53
constant: false
boundary condition: true
has only substance units: false

metaM ksi deg38 l
notes: FORMULA: C54H91N3O41 CHARGE: 0
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 38
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false

metaM 2hexdtricoa m
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
initial amount: NaN
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species

metaR r2386
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM glx m
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
has only substance units: false
name: glyoxylate
is: CHEBI:36655
is: HMDB00119
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_fc11cda1_ff64_47f9_bae3_9ddedb28d536
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1340
name: COX6B1
is: P14854
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR GALACGLCGALGBSIDEte
is: SBO:0000185
product: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110047#
name: galacglcgalgbside hs transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_c138f10d_ed5a_4adc_b352_dea80b472616
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: GPX5
is encoded by: hsa:2880
boundary condition: true
is: O75715
constant: false
initial concentration: NaN

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR r1589
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000185

metaM nm2masn g
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: C05884
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C42H70N3O30X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110047#_77e1549c_5ce4_4d63_bb2b_0351a7bd28fd
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is: Q9NWU1
initial concentration: NaN
boundary condition: true
name: OXSM
is encoded by: hsa:54995

metaM glu L c
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:29985
name: L-glutamate(1-)
is: SBO:0000247
initial amount: NaN
is: HMDB00148
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_e3716fe4_080e_432f_872e_598a67007ff3
initial concentration: NaN
is encoded by: hsa:728637
boundary condition: true
name: _728637_1_c
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_d849e4a3_20fb_4f8d_b549_a5b4e26e219a
is: SBO:0000252
is encoded by: hsa:4143
constant: false
name: MAT1A
type: Species
is: Q00266
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaM o2s x
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: superoxide
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:18421
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110047#_8d63491e_b094_4e8a_a119_deb6d460b717
initial amount: NaN
is: P49748
is encoded by: hsa:37
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: ACADVL
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110047#_5e27d1e6_7939_4145_9928_3416d231c182
name: ENTPD2
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q5SPY7
is encoded by: hsa:954

http://identifiers.org/biomodels.db/MODEL1310110047#_d5cb9144_4d39_4813_bc99_b5d2dcca82af
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:10195
name: ALG3
is: SBO:0000252

metaR r2539
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
type: Reaction
reactant: MODEL1310110047#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_1a5accb4_45af_497a_be8a_1657358bc3c8
type: Species
is: SBO:0000252
has only substance units: false
name: CAT
is encoded by: hsa:847
initial concentration: NaN
is: P04040
initial amount: NaN
boundary condition: true
constant: false

metaR r2387
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110047#
is: SBO:0000185
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_5570164f_d130_490d_a901_a3ebdf655f7b
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SLC5A8
type: Species
is encoded by: hsa:160728
is: SBO:0000252
initial amount: NaN
constant: false
is: Q8N695

metaM txa2 c
initial amount: NaN
name: thromboxane A2(1-)
initial concentration: 1.0
is: CHEBI:57445
type: Species
is: HMDB01452
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198

metaR H2Otp
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110047#
name: H2O transport, peroxisomal

metaR r1588
reactant: MODEL1310110047#
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0010
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.11.1.6
is: SBO:0000176
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (25841.1) or (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:12054464,PMID:1657986 NOTES:
type: Reaction
reversible: false
fast: false
name: hydrogen-peroxide:hydrogen-peroxide oxidoreductase EC:1.11.1.6
modifier: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#

metaM vacccoa c
has only substance units: false
name: vaccenyl coenzyme A
is: HMDB06521
is: SBO:0000247
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/9543677

metaM agm m
is: HMDB01432
has only substance units: false
is: CHEBI:58145
initial amount: NaN
notes: FORMULA: C5H16N4 CHARGE: 2 INCHI: InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9)/p+2 HEPATONET_1.0_ABBREVIATION: HC00171 EHMN_ABBREVIATION: C00179
constant: false
name: agmatinium(2+)
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM retn c
type: Species
initial amount: NaN
boundary condition: false
name: all-trans-retinoate
constant: false
is: CHEBI:35291
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_79396217_6e83_4579_96bf_9041b7ccc3ce
name: GBA
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2629
is: SBO:0000252
is: P04062

http://identifiers.org/biomodels.db/MODEL1310110047#_438f11e8_17c0_46c7_b979_26c7b6bfe01e
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: HAS3
is: Q96RV2
is encoded by: hsa:3038
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaM ptrc e
is: CHEBI:326268
is: HMDB01414
is: C00134
type: Species
name: Putrescine
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

http://identifiers.org/biomodels.db/MODEL1310110047#_3dcf0678_1d79_48c0_90ad_29271d1d9daa
initial amount: NaN
is: Q06278
is: SBO:0000252
has only substance units: false
is encoded by: hsa:316
constant: false
boundary condition: true
initial concentration: NaN
name: AOX1
type: Species

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r2497
reactant: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
product: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
fast: false
kinetic law: MODEL1310110047#

metaM retinol cis 11 c
is: HMDB06216
is: CHEBI:16302
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
is: SBO:0000247
name: 11-cis-retinol
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM succoa m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
boundary condition: false
name: Succinyl-CoA
initial concentration: 1.0
type: Species
constant: false
is: HMDB01022
initial amount: NaN
is: SBO:0000247
is: CHEBI:57292
has only substance units: false

metaR r1587
is: SBO:0000185
type: Reaction
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false

metaR r2384
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
fast: false

metaR C4tmc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

metaR H2Otm
is: SBO:0000185
name: H2O transport, mitochondrial
is described by: ECO:0000269
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
fast: false
reversible: true
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
kinetic law: MODEL1310110047#

metaM m8masn r
initial concentration: 1.0
has only substance units: false
type: Species
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C05876

metaR SIAASE3ly
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
name: sialidase, lysosomal
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110047#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_d2bc4f8d_918b_492d_b2be_83355fb5416d
is encoded by: hsa:2720
constant: false
is: P16278
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: GLB1
has only substance units: false
initial amount: NaN

metaM oagd3 hs c
type: Species
has only substance units: false
is: SBO:0000247
name: 9-O-Acetylated GD3
is: HMDB01514
constant: false
is: CHEBI:17315
is: C00329
initial amount: NaN
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
boundary condition: false
initial concentration: 1.0

metaM cala c
is: HMDB00026
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
is: SBO:0000247
constant: false
boundary condition: false
name: N-carbamoyl-beta-alaninate
is: CHEBI:11892
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_cb3f7880_dc92_4f5f_9cd4_1b5499bcdf13
boundary condition: true
type: Species
name: HCST
initial concentration: NaN
is: Q9UBK5
is encoded by: hsa:10870
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM mma c
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
is: HMDB00164
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: methylammonium
is: CHEBI:59338
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM txa2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
name: thromboxane A2(1-)
is: CHEBI:57445
is: HMDB01452
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM ksi deg15 l
type: Species
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 15
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936

metaR r2385
fast: false
kinetic law: MODEL1310110047#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_71224ff1_e5ba_4011_8b4f_e0a558b96119
is encoded by: hsa:768
is: SBO:0000252
name: CA9
boundary condition: true
initial amount: NaN
constant: false
is: Q16790
initial concentration: NaN
type: Species
has only substance units: false

metaR r1586
is described by: ECO:0000000
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM nrvnc e
is: SBO:0000247
initial concentration: 1.0
name: nervonate
is: HMDB02368
type: Species
is: CHEBI:32392
boundary condition: false
has only substance units: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial amount: NaN
constant: false

metaR H2Otn
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
name: H2O transport, nuclear
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR 5ADTSTSTERONESte
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
name: sulfonated testosterone transport
reactant: MODEL1310110047#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110047#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_da42587f_ea4e_42ff_9d4a_d49591db1575
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q9H490
name: PIGU
is encoded by: hsa:128869
is: SBO:0000252

metaM ksii core2 pre4 g
is: C00130
name: keratan sulfate II biosynthesis, precursor 4
initial amount: NaN
is: HMDB00175
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58053

metaM HC00900 c
name: Methylmalonate
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:30860
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f29de4ae_12d6_41c7_966a_d0d142260380
type: Species
is: Q8NFF5
constant: false
is encoded by: hsa:80308
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: FLAD1
has only substance units: false
initial concentration: NaN

metaM 3htdcoa m
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
is: HMDB02288
has only substance units: false
boundary condition: false
type: Species
constant: false

metaR r1401
is version of: http://identifiers.org/ec-code/3.2.1.35
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.51
is version of: http://identifiers.org/ec-code/2.7.10.1
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
fast: false
product: MODEL1310110047#
name: Facilitated diffusion
modifier: MODEL1310110047#
is: SBO:0000185

metaR PETHCT
type: Reaction
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110047#
is described by: ECO:0000269
name: phosphoethanolamine cytidyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.14
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#

metaR RTOTALFATPc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaM udpg r
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:58367
constant: false
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: HMDB00286
has only substance units: false

metaR r1594
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110047#

metaM dcyt c
constant: false
is: C00881
initial concentration: 1.0
boundary condition: false
is: HMDB00014
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
is: CHEBI:15698
initial amount: NaN
type: Species
has only substance units: false

metaR 4HBZFm
is: SBO:0000176
name: 4-hydroxybenzoate formation
kinetic law: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
type: Reaction

metaM lnlncacoa m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
boundary condition: false
is: HMDB06290
initial concentration: 1.0
name: alpha-Linolenoyl-CoA
is: CHEBI:51985
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaM c6crn c
notes: FORMULA: C13H25NO4 CHARGE: 0
boundary condition: false
name: hexanoyl carnitine
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00705
is: SBO:0000247
initial amount: NaN

metaM docosahexcoa m
has only substance units: false
initial concentration: 1.0
name: 3,7,10,13,16,19-docosahexenoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
type: Species

metaM succoa x
initial concentration: 1.0
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01022
boundary condition: false
name: Succinyl-CoA

metaM glu L m
initial concentration: 1.0
name: L-glutamate(1-)
is: HMDB00148
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: CHEBI:29985
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false

metaM h g
has only substance units: false
is: CHEBI:24636
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
constant: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial amount: NaN
type: Species
is: CHEBI:57527
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01163

metaR PPAn
is described by: ECO:0000000
type: Reaction
product: MODEL1310110047#
reversible: false
kinetic law: MODEL1310110047#
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
name: inorganic diphosphatase, nuclear
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_72fd93e7_a1aa_4081_8d2c_8b6f3bee32c9
is encoded by: hsa:2984
name: GUCY2C
is: SBO:0000252
type: Species
initial concentration: NaN
is: P25092
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaR r0027
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is: SBO:0000176
product: MODEL1310110047#
reversible: true
fast: false
modifier: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.14.13.39

metaR VALTAm
is described by: ECO:0000269
reactant: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
reversible: true
name: valine transaminase, mitochondiral
fast: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM CE2422 m
constant: false
is: HMDB11123
type: Species
is: CHEBI:28387
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
boundary condition: false
initial concentration: 1.0

metaR ARGNm
fast: false
product: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (384.1) SUBSYSTEM: Urea cycle EC Number: 3.5.3.1 Confidence Level: 4 AUTHORS: PMID:9144563 NOTES:SAB m
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.3.1
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
type: Reaction
name: arginase (m)
is: SBO:0000176

metaR r1595
product: MODEL1310110047#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ps hs m
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: ps_hs[m]
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:18303
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM ksii core2 pre5 g
is: C00130
has only substance units: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00175
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
is: CHEBI:58053

metaR CTPtn
is: SBO:0000185
reversible: true
type: Reaction
name: CTP diffusion in nucleus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#

metaR r0899
is described by: ECO:0000000
reactant: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reversible: true
kinetic law: MODEL1310110047#
fast: false
product: MODEL1310110047#
is: SBO:0000185
name: Amino acid transporter ATB0+ Facilitated diffusion

metaM lpchol hs e
constant: false
type: Species
name: lysophosphatidylcholine
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
boundary condition: false
is: CHEBI:60479
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_bc008ce7_f640_45f7_9a41_2f6e2a1c2159
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _AA854479_1_m
is encoded by: hsa:AA854479
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_175efbdb_ecda_47b0_91a9_713d3d030061
initial concentration: NaN
name: _AW277253_1_c
is: SBO:0000252
is encoded by: hsa:AW277253
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaM dec24dicoa x
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 2,4-decadienoylcoa
is: HMDB01168
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_2fe54440_3329_4f99_90ec_9de4894c2847
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
name: ACAA2
initial amount: NaN
is: SBO:0000252
is: P42765
is encoded by: hsa:10449

metaM 3octdectecoa x
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 3,6,9,12-octadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110047#_095ef8eb_95fe_441b_83d1_ee5f2e1a33da
has only substance units: false
is encoded by: hsa:5172
name: SLC26A4
constant: false
type: Species
boundary condition: true
is: O43511
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM dcyt e
is: C00881
has only substance units: false
is: HMDB00014
boundary condition: false
initial concentration: 1.0
name: Deoxycytidine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
type: Species
constant: false

metaR r1596
fast: false
reversible: true
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
is described by: ECO:0000000

metaR PPAm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
type: Reaction
modifier: MODEL1310110047#
is described by: ECO:0000269
reactant: MODEL1310110047#
name: inorganic diphosphatase
fast: false
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_ff8c1a77_6071_41d1_984b_54ade6fa9999
is encoded by: hsa:130752
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: MDH1B
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q5I0G3

metaR ACALDt
is described by: ECO:0000000
reversible: true
name: acetaldehyde reversible transport
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
fast: false

metaR C4STMO2Pr
type: Reaction
fast: false
kinetic law: MODEL1310110047#
name: C-4 methyl sterol oxidase
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reactant: MODEL1310110047#
reversible: false
product: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000000

metaM h c
name: proton
is: C00080
is: http://identifiers.org/pubchem.compound/3380
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
is: CHEBI:24636
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaM hs deg4 l
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16126
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
name: heparan sulfate, degradation product 4
type: Species
boundary condition: false
constant: false

metaR GRTTx
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110047#
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000176
name: geranyltranstransferase
type: Reaction
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ

metaR C142OHe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaM h e
is: CHEBI:24636
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
name: proton
is: C00080
has only substance units: false

metaR r1597
reversible: true
is: SBO:0000185
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_1571441e_d56f_4a58_9e64_d268f03ec7a8
is: SBO:0000252
has only substance units: false
is: P07205
constant: false
initial amount: NaN
boundary condition: true
name: PGK2
initial concentration: NaN
is encoded by: hsa:5232
type: Species

metaM 2dr5p c
initial amount: NaN
has only substance units: false
is: CHEBI:57651
type: Species
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
constant: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM hs deg5 l
is: CHEBI:17895
initial amount: NaN
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: HMDB00158
name: heparan sulfate, degradation product 5
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaM ksii core2 deg9 l
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936
notes: FORMULA: C30H50N3O20X CHARGE: 0
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 9

metaM lpchol hs c
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: CHEBI:60479
name: lysophosphatidylcholine
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR SUCOASm
type: Reaction
fast: false
reactant: MODEL1310110047#
is described by: ECO:0000000
modifier: MODEL1310110047#
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
kinetic law: MODEL1310110047#
name: Succinate--CoA ligase (ADP-forming)

metaR LDH D
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
is described by: ECO:0000304
name: D-lactate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.2.4
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)

metaR CHAT
name: Choline O-acetyltransferase
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
product: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
is described by: ECO:0000269
kinetic law: MODEL1310110047#
type: Reaction
reactant: MODEL1310110047#
modifier: MODEL1310110047#
is: SBO:0000176
reversible: true

metaM eicostetcoa m
initial concentration: 1.0
is: SBO:0000247
is: C16164
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
constant: false
name: eicosatetranoyl coenzyme A
boundary condition: false
type: Species
initial amount: NaN

metaM CE1936 e
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:36781
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
initial concentration: 1.0
name: spermine dialdehyde

metaM ptrc c
initial amount: NaN
type: Species
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
has only substance units: false
initial concentration: 1.0
constant: false
is: C00134
is: CHEBI:326268
name: Putrescine
boundary condition: false
is: SBO:0000247
is: HMDB01414

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_c252357d_41da_43c6_8d43_b8b38c0faf93
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: O75874
initial concentration: NaN
type: Species
is encoded by: hsa:3417
name: IDH1

metaR LGNCCOAtx
type: Reaction
product: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110047#
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110047#_7103b4e3_d76c_4ae4_863d_31e8cccd7e24
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:4351
has only substance units: false
boundary condition: true
is: P34949
initial concentration: NaN
name: MPI

metaM glx x
initial amount: NaN
is: CHEBI:36655
initial concentration: 1.0
is: HMDB00119
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
type: Species
constant: false
name: glyoxylate
boundary condition: false
is: SBO:0000247

metaM dtdp e
initial amount: NaN
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
boundary condition: false
is: HMDB01274
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_5b6aac1c_b4f8_4b29_a52a_065587b6d3a9
initial concentration: NaN
constant: false
initial amount: NaN
name: GNS
is: Q7Z3X3
has only substance units: false
boundary condition: true
is encoded by: hsa:2799
type: Species
is: SBO:0000252

metaR NaKt
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
is: SBO:0000185
name: Na+/K+ exchanging ATPase
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.6.3.9
reversible: false
modifier: MODEL1310110047#
fast: false
product: MODEL1310110047#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110047#_ea803e14_d2b7_4e19_8c50_5a62bd190927
has only substance units: false
initial amount: NaN
is: P15848
name: ARSB
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:411

metaR r0755
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
type: Reaction
reactant: MODEL1310110047#
modifier: MODEL1310110047#
product: MODEL1310110047#
reversible: true
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110047#
fast: false
is: SBO:0000176

metaR r1590
is: SBO:0000185
kinetic law: MODEL1310110047#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110047#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110047#

metaR PLA2 2e
reactant: MODEL1310110047#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110047#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.4
kinetic law: MODEL1310110047#
reversible: false
name: phospholipase A2
fast: false
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_4dab0cbd_59ad_46eb_a532_dcbf0f78ff1a
boundary condition: true
is: SBO:0000252
is: P14618
initial amount: NaN
constant: false
name: PKM2
is encoded by: hsa:5315
has only substance units: false
initial concentration: NaN
type: Species

metaM lnlc e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:30245
is: HMDB00673
name: linoleate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_620cca93_2fca_4ce1_b56a_3463bc70e4c4
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5052
constant: false
has only substance units: false
name: PRDX1

metaM 3uib c
type: Species
constant: false
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
has only substance units: false
is: HMDB02031
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:1670
name: 3-Ureidoisobutyrate
is: SBO:0000247

metaR C142OHc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

metaR AMETt2m
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
is described by: ECO:0000269
name: S-Adenosyl-L-methionine reversible transport, mitochondrial

metaR NACHEX18ly
modifier: MODEL1310110047#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
product: MODEL1310110047#

metaR RE1522M
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110047#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
name: RE1522
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true

metaR FUT16g
reactant: MODEL1310110047#
is described by: ECO:0000269
product: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.69
kinetic law: MODEL1310110047#
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110047#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110047#_7cef8ff4_48d8_4406_862d_7f9df4688b3a
initial concentration: NaN
is encoded by: hsa:4541
is: Q7GXZ1
name: ND6
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR UDPGLCAter
reversible: true
fast: false
is described by: ECO:0000269
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110047#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
type: Reaction
modifier: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_fd76e81f_d447_4934_9709_537b0d340e74
has only substance units: false
is: SBO:0000252
is: P51160
boundary condition: true
type: Species
constant: false
is encoded by: hsa:5146
initial concentration: NaN
name: PDE6C
initial amount: NaN

metaR SPHMYLNtg
reversible: true
product: MODEL1310110047#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110047#
name: sphingomyelin intracellular transport
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
fast: false

metaR r0754
reactant: MODEL1310110047#
product: MODEL1310110047#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110047#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
modifier: MODEL1310110047#
reversible: true
is described by: ECO:0000000

metaR r1591
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is: SBO:0000185
reversible: true
type: Reaction

metaM dhcrm hs c
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:31488
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: dihydroceramide

metaR CHOLD2m
fast: false
name: choline dehydrogenase (FAD acceptor), mitochondrial
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.99.1
product: MODEL1310110047#
is described by: ECO:0000269
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
kinetic law: MODEL1310110047#
reversible: false
type: Reaction

metaR RE2986X
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110047#
name: RE2986
type: Reaction
reactant: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_1d42a12d_e0c7_45f5_a3d2_cbbbb2b21efc
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:129642
initial concentration: NaN
is: SBO:0000252
name: MBOAT2
constant: false
has only substance units: false
is: Q6ZWT7

metaR SMPD3g
reversible: false
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.4.12
fast: false
is: SBO:0000176
product: MODEL1310110047#
type: Reaction
modifier: MODEL1310110047#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reactant: MODEL1310110047#
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)

metaM noncoa m
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB13028
initial amount: NaN
name: nonanoylcoa
has only substance units: false
is: C01942

http://identifiers.org/biomodels.db/MODEL1310110047#_00158e27_2a9b_46f4_8da2_854227bab029
name: CPOX
type: Species
is encoded by: hsa:1371
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P36551
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_eb38493d_e77d_4045_b06b_c092238689bc
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR CITL
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
fast: false
reactant: MODEL1310110047#
name: Citrate lyase
product: MODEL1310110047#
is described by: ECO:0000000
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reversible: false
is: SBO:0000176
type: Reaction

metaM dtdp c
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: C00363
name: dTDP
is: CHEBI:58369
is: HMDB01274
initial concentration: 1.0
boundary condition: false

metaR DHFtm
product: MODEL1310110047#
kinetic law: MODEL1310110047#
name: dihydrofolate reversible mitochondrial transport
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110047#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_f7868140_6824_417b_a58f_136755b466fe
type: Species
has only substance units: false
is encoded by: hsa:8704
name: B4GALT2
is: O60909
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r1592
kinetic law: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110047#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM octe5coa x
boundary condition: false
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
name: 5-octenoylcoa
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM C02470 e
is: C02470
name: Xanthurenic acid
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5485
is: HMDB00881
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470

metaM lnlc c
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:30245
is: SBO:0000247
name: linoleate
is: HMDB00673

metaR r0753
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110047#
product: MODEL1310110047#

metaR C6COAt
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaR MANtg
kinetic law: MODEL1310110047#
name: mannose efflux from Golgi apparatus
reactant: MODEL1310110047#
fast: false
product: MODEL1310110047#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110047#_75cbb183_02f0_41b3_befd_571e09600afa
type: Species
initial amount: NaN
is encoded by: hsa:1606
is: P23743
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: DGKA
has only substance units: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM nrpphr c
name: Norepinephrine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
initial amount: NaN
is: HMDB00216
is: CHEBI:33569
type: Species
boundary condition: false
constant: false

metaR r1593
is described by: ECO:0000000
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110047#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110047#_f22b23d4_a1d3_4839_9c10_0b654c09a5d2
is: Q9NVE7
type: Species
is encoded by: hsa:55229
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: PANK4
is: SBO:0000252
boundary condition: true

metaR FUT911g
name: Alpha-(1,3)-fucosyltransferase
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.152
modifier: MODEL1310110047#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110047#_3d5597cf_0a6d_4c0e_9663_8daf577caaae
is encoded by: hsa:56954
initial amount: NaN
constant: false
is: Q9NQR4
type: Species
name: NIT2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110047#_9e161057_7e3c_4814_9989_1626071c3804
initial concentration: NaN
constant: false
initial amount: NaN
is: B7Z3I7
type: Species
is encoded by: hsa:4190
is: SBO:0000252
name: MDH1
has only substance units: false
boundary condition: true

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR GALASE17ly
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
fast: false
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is: SBO:0000176
name: beta-galactosidase, lysosomal

metaM lneldccoa m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
name: linoelaidyl coenzyme A
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_02a6d75f_89c1_4cc9_a454_0a2f3e70d6a2
is encoded by: hsa:1346
boundary condition: true
initial concentration: NaN
name: COX7A1
type: Species
initial amount: NaN
is: P24310
constant: false
is: SBO:0000252
has only substance units: false

metaR r0752
fast: false
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110047#_cb644924_427d_41ea_a33a_12485d363546
is encoded by: hsa:2592
constant: false
name: GALT
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: E7ET32

http://identifiers.org/biomodels.db/MODEL1310110047#_5d1f1408_38bb_4376_a082_277e705c5302
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6561
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: Q9BZW2
initial amount: NaN
name: SLC13A1

metaM decdicrn c
is: HMDB13325
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C17H29NO4 CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: decadienoyl carnitine

metaR r0892
modifier: MODEL1310110047#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
product: MODEL1310110047#
name: Facilitated diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.2.27
is described by: ECO:0000000
reactant: MODEL1310110047#

metaM dmnoncrn c
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0
name: 4,8-dimethylnonanoyl carnitine
boundary condition: false
initial amount: NaN
has only substance units: false

metaM ps hs c
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: ps_hs[c]
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:18303
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_175657e6_4152_47e5_9019_cf2c11c41e3c
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: _M68895_1_c
is encoded by: hsa:M68895
initial amount: NaN
boundary condition: true

metaM vacccoa m
has only substance units: false
name: vaccenyl coenzyme A
is: SBO:0000247
is: HMDB06521
is: http://identifiers.org/pubchem.compound/9543677
type: Species
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
constant: false
initial amount: NaN
boundary condition: false

metaR NDP3ex
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110047#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (GDP), extracellular
modifier: MODEL1310110047#

metaM gal c
initial amount: NaN
name: D-Galactose
is: CHEBI:0
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00143
is: C00124
boundary condition: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0

metaM dad 2 e
name: 2-deoxyadenosine
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
type: Species
constant: false
is: CHEBI:17256
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00101

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM ahcys c
initial concentration: 1.0
is: HMDB00939
initial amount: NaN
is: CHEBI:16680
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
type: Species
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
is: C00021
constant: false
has only substance units: false

metaM C02470 c
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
has only substance units: false
is: HMDB00881
is: SBO:0000247
name: Xanthurenic acid
is: C02470
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5485

http://identifiers.org/biomodels.db/MODEL1310110047#_0f81710a_d096_4eaa_a2e8_050a0199d010
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NPR2
constant: false
is encoded by: hsa:4882
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110047#_906ff9c9_0112_4409_89f8_ec8d1d46a4ec
initial concentration: NaN
initial amount: NaN
name: CA4
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:762
is: Q6FHI7
boundary condition: true

metaR FAOXC184C164m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR METt4
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110047#
name: L-methionine transport in via sodium symport
is: SBO:0000185
fast: false
modifier: MODEL1310110047#

metaR URIDK2m
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
fast: false
reversible: true
name: uridylate kinase (dUMP), mitochondrial
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110047#
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_c652a2e2_bb48_4f8a_be3b_3a212b3fc23e
boundary condition: true
name: _PRO1933_1_m
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:PRO1933

metaM cit c
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
initial concentration: 1.0
is: CHEBI:16947
is: C00158
has only substance units: false
name: Citrate

metaM eicostetcoa c
initial concentration: 1.0
name: eicosatetranoyl coenzyme A
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
has only substance units: false
is: C16164

metaM ps hs e
is: CHEBI:18303
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
is: SBO:0000247
type: Species
name: phosphatidylserine
has only substance units: false

metaR PRPPS
modifier: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
name: phosphoribosylpyrophosphate synthetase
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.6.1
product: MODEL1310110047#
reversible: true

metaM nrpphr e
initial amount: NaN
constant: false
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial concentration: 1.0
name: Norepinephrine
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00216
type: Species

metaR 2MB2COAc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaR LNLNCAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110047#
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110047#
product: MODEL1310110047#

metaM rib D e
initial concentration: 1.0
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: CHEBI:16988
is: SBO:0000247
name: D-ribose
has only substance units: false
is: HMDB00283
initial amount: NaN
constant: false
boundary condition: false

metaM ctdecdcoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
type: Species
is: C08277
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: cis2trans4decadienoylcoa
is: HMDB00792

http://identifiers.org/biomodels.db/MODEL1310110047#_64de4bbf_a764_4066_a004_f1fecedb224e
is: P22234
type: Species
is: SBO:0000252
initial amount: NaN
name: PAICS
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10606
constant: false
has only substance units: false

metaM dolp U r
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
is: CHEBI:57683
constant: false

metaM ksi deg31 l
is: SBO:0000247
boundary condition: false
is: CHEBI:16953
is: HMDB00812
name: keratan sulfate I, degradation product 31
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

metaM 4mptnl m
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 4-methylpentanal
initial amount: NaN
boundary condition: false
is: CHEBI:17998
has only substance units: false
is: HMDB01318
type: Species
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373

metaM fadh2 m
is: SBO:0000247
name: Flavin adenine dinucleotide reduced
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:58307
boundary condition: false
constant: false
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: C01352
is: HMDB01197

metaR r0472
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
reactant: MODEL1310110047#
is: SBO:0000176
product: MODEL1310110047#
fast: false
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaM dad 2 c
name: 2-deoxyadenosine
is: HMDB00101
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:17256
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110047#_aba011f5_68f5_43fe_b7f3_5b2a15c1d042
initial amount: NaN
is: B7Z2T0
name: ATP1A3
is encoded by: hsa:478
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_851983ad_837d_4c15_a840_df8f1251dec8
is encoded by: hsa:8525
is: SBO:0000252
has only substance units: false
is: G3V0F6
name: DGKZ
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaR r2101
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110047#
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
fast: false
reversible: true

metaR PSP L
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: phosphoserine phosphatase (L-serine)
fast: false
modifier: MODEL1310110047#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.3
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_ac099ff7_a726_467a_a4c5_586fdd6f211d
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: SLC26A3
is encoded by: hsa:1811
initial concentration: NaN
initial amount: NaN
constant: false
is: P40879

http://identifiers.org/biomodels.db/MODEL1310110047#_07e59e62_695e_4d62_b496_fb07bce47507
is encoded by: hsa:6487
initial amount: NaN
name: ST3GAL3
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaM anth c
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
is: CHEBI:16567
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaM 2hexdtricoa x
initial amount: NaN
is: SBO:0000247
is: HMDB02288
name: 2,7,10-hexadecatrienoylcoa
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
type: Species

metaR FAOXC10C10OHm
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaM kynate c
is: CHEBI:58454
constant: false
is: HMDB00715
name: kynurenate
has only substance units: false
boundary condition: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM 2dp6mobq m
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
type: Species
is: CHEBI:50773
constant: false
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR LPS2e
product: MODEL1310110047#
type: Reaction
reversible: false
modifier: MODEL1310110047#
name: lipase, extracellular
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
reactant: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_9b20a416_f552_4ad9_a16b_c816a3beb929
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: LDHD
is: SBO:0000252
boundary condition: true
is encoded by: hsa:197257
constant: false

metaR r2100
kinetic law: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110047#
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110047#
product: MODEL1310110047#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaM HC02214 e
constant: false
boundary condition: false
name: prostaglandin-f1alpha
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
type: Species
initial amount: NaN
has only substance units: false

metaM gar c
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457
initial amount: NaN
type: Species
is: C03838
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: HMDB02022

metaR DDECE1CRNe
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaR PROt2r
name: L-proline reversible transport via proton symport
product: MODEL1310110047#
type: Reaction
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
fast: false
is: SBO:0000185

metaR LDH L
type: Reaction
is: SBO:0000176
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: true
name: L-lactate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
fast: false

metaR NORANMT
is: SBO:0000176
modifier: MODEL1310110047#
name: noradrenaline N-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.28
is described by: ECO:0000269
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
fast: false
product: MODEL1310110047#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_dd1b8ea0_f3d9_4cb4_94e1_f412dea5425d
name: IK
is: SBO:0000252
is encoded by: hsa:3550
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q13123
initial concentration: NaN

metaR AG13T13g
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176

metaM octe5coa m
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
name: 5-octenoylcoa
type: Species
is: SBO:0000247
has only substance units: false
constant: false

metaM ser D e
is: CHEBI:16523
boundary condition: false
type: Species
is: HMDB03406
constant: false
initial concentration: 1.0
name: D-serine
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaM dtdp m
is: CHEBI:58369
type: Species
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01274
is: SBO:0000247
is: C00363
constant: false
initial amount: NaN

metaR IDOAASE1ly
fast: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
name: alpha-L-iduronidase, lysosomal
type: Reaction
product: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110047#

metaM anth e
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial amount: NaN
has only substance units: false
is: CHEBI:16567
initial concentration: 1.0
boundary condition: false
is: HMDB01123
type: Species
name: anthranilate
is: SBO:0000247
constant: false

metaM dec24dicoa m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
name: 2,4-decadienoylcoa
constant: false

metaR COQ3m
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.114
reversible: false
modifier: MODEL1310110047#
is described by: ECO:0000269
name: methyltransferase COQ3
product: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
is: SBO:0000176
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_42e505c3_673f_4e84_a756_4883f7974e1e
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9856
boundary condition: true
is: F5H123
is: SBO:0000252
constant: false
name: DYLX2
has only substance units: false

metaM fad e
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
has only substance units: false
initial concentration: 1.0
is: C00016
is: SBO:0000247
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

http://identifiers.org/biomodels.db/MODEL1310110047#_ba3f04c1_4635_4e8b_8a40_dce35d760a7b
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: A8K3J4
boundary condition: true
type: Species
constant: false
has only substance units: false
name: CA14
is encoded by: hsa:23632

http://identifiers.org/biomodels.db/MODEL1310110047#_e0d056d7_7542_4468_9af4_f0c74232f34f
constant: false
is encoded by: hsa:LOC727762
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: _LOC727762_1_m
is: SBO:0000252
has only substance units: false

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR r2103
product: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_d7ccb3f4_77ba_41a3_8d29_de82effde79e
name: OGDHL
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: Q9ULD0
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55753

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR HXPRT
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
modifier: MODEL1310110047#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110047#
is: SBO:0000176
reversible: false
product: MODEL1310110047#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
kinetic law: MODEL1310110047#
fast: false

metaR G3PD1
fast: false
modifier: MODEL1310110047#
product: MODEL1310110047#
reversible: true
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaR NTD3
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110047#
product: MODEL1310110047#
fast: false
name: 5'-nucleotidase (dCMP)
modifier: MODEL1310110047#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_e94cd161_b69d_4ba8_b1b0_62fca9442dd5
is: SBO:0000252
is encoded by: hsa:6120
boundary condition: true
initial concentration: NaN
is: Q96AT9
initial amount: NaN
constant: false
type: Species
name: RPE
has only substance units: false

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM lneldccoa c
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB06521
is: http://identifiers.org/pubchem.compound/9543677
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
name: linoelaidyl coenzyme A
initial concentration: 1.0

metaM CE4794 m
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: cis-6-dodecenoyl-CoA
is: CHEBI:57923
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_42596af6_1457_4f90_8254_adc7539d256a
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4121
is: P33908
constant: false
type: Species
name: MAN1A1
initial concentration: NaN
initial amount: NaN

metaM fadh2 r
has only substance units: false
is: SBO:0000247
is: HMDB01197
boundary condition: false
constant: false
type: Species
is: CHEBI:58307
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
name: FADH2(2-)

metaR FAOXC8C6m
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR ACACT6p
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110047#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110047#
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
name: acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
is described by: ECO:0000269
type: Reaction
product: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_ea1b3f6b_2a4b_4130_972a_5f42bac7ebb7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: VNN3
boundary condition: true
has only substance units: false
is encoded by: hsa:55350

metaR r2102
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110047#
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
product: MODEL1310110047#
kinetic law: MODEL1310110047#

http://identifiers.org/biomodels.db/MODEL1310110047#_cbec5a3d_5586_4bcd_942d_41b90fa0cffe
is: Q92911
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:6528
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC5A5

metaM o2 x
name: O2
is: C00007
is: SBO:0000247
initial concentration: 1.0
is: HMDB01377
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:15379
boundary condition: false

metaM ksi deg20 l
type: Species
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 20
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110047#_0ec64a20_077d_4108_a6d7_4b5d18860bbc
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: PLCB1
is: SBO:0000252
is encoded by: hsa:23236
type: Species

metaM ser D c
boundary condition: false
is: CHEBI:16523
type: Species
is: HMDB03406
name: D-serine
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN

metaR CHOLATEt
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
is described by: ECO:0000269
name: cholate transport via bicarbonate countertransport
type: Reaction
product: MODEL1310110047#
fast: false
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000185

metaM ahcys e
is: HMDB00939
type: Species
has only substance units: false
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: C00021
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR NACHEX14ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
fast: false
name: beta-N-acetylhexosaminidase, lysosomal

metaM gal e
boundary condition: false
name: D-Galactose
is: SBO:0000247
is: C00124
initial concentration: 1.0
is: HMDB00143
has only substance units: false
constant: false
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0
initial amount: NaN
type: Species

metaM cholcoaone x
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
has only substance units: false
is: SBO:0000247
is: CHEBI:58507
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: HMDB06891
constant: false

metaR r2105
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110047#
is: SBO:0000185

metaM fad c
name: Flavin adenine dinucleotide oxidized
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
is: CHEBI:16238
is: SBO:0000247
boundary condition: false

metaR AMPTASECG
is: SBO:0000176
is described by: ECO:0000212
reactant: MODEL1310110047#
fast: false
modifier: MODEL1310110047#
name: alanyl aminopeptidase (cys-gly)
type: Reaction
product: MODEL1310110047#
reversible: false
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.1 Confidence Level: 1 AUTHORS: PMID:12675513 NOTES:SAB. activity measured in cytosol rat liver; IT IS leucine aminopeptidase (EC3.4.11.1) NOT alanyl aminopeptidase EC3.4.11.2 which shows > 80% of the activity; sequence homology rat-human not yet verified; annotation 'extracellular' under B column ERROR
is version of: http://identifiers.org/ec-code/3.4.11.2
kinetic law: MODEL1310110047#

metaR NTD1
kinetic law: MODEL1310110047#
type: Reaction
product: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000269
name: 5'-nucleotidase (dUMP)

http://identifiers.org/biomodels.db/MODEL1310110047#_metaR_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110047#
reactant: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
type: Reaction

metaM 3octdectecoa m
type: Species
has only substance units: false
constant: false
name: 3,6,9,12-octadecatetraenoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247

metaR DOLPMT4 Uer
product: MODEL1310110047#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185

metaR GLUDym
is described by: ECO:0000269
product: MODEL1310110047#
reversible: true
name: glutamate dehydrogenase (NADP), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110047#_0e67d529_76c4_4065_933c_410e8b42968b
boundary condition: true
initial amount: NaN
constant: false
name: GLRX2
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:51022
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
constant: false
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false
is: HMDB00304
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57847
initial amount: NaN
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1

http://identifiers.org/biomodels.db/MODEL1310110047#_9a41bf6a_fc6e_4ee9_bb02_c1db4ab29d7a
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: GBA
initial amount: NaN
is: B7Z6S1
is encoded by: hsa:2629

http://identifiers.org/biomodels.db/MODEL1310110047#_82b0e469_a118_43ad_9c36_e9dd4cb5fbb7
name: MCEE
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: Q96PE7
has only substance units: false
is encoded by: hsa:84693
constant: false

http://identifiers.org/biomodels.db/MODEL1310110047#_894caf19_9e2c_4e13_b5e4_96b5ac54bf84
name: _AI222095_1_e
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI222095
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110047#_097f3c7a_c03d_46e7_a68e_e187feb44b71
name: CTPS2
is encoded by: hsa:56474
constant: false
is: SBO:0000252
is: Q9NRF8
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM rib D c
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
name: D-ribose
constant: false
is: HMDB00283
initial concentration: 1.0
is: CHEBI:16988

metaR r2104
reactant: MODEL1310110047#
kinetic law: MODEL1310110047#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110047#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
product: MODEL1310110047#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR TETPENT6COAtx
type: Reaction
name: fatty acid intracellular transport
product: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110047#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110047#
is described by: ECO:0000000
fast: false

metaR S23T2g
kinetic law: MODEL1310110047#
is: SBO:0000176
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.4.99.4
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
product: MODEL1310110047#
is described by: ECO:0000000
reactant: MODEL1310110047#
reversible: false
type: Reaction

metaM pydam c
type: Species
constant: false
is: HMDB01431
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: C00534
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57761
name: Pyridoxamine
boundary condition: false

metaR NTD8
kinetic law: MODEL1310110047#
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110047#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110047#
is described by: ECO:0000269
is: SBO:0000176
name: 5'-nucleotidase (dGMP)
reactant: MODEL1310110047#

metaR PI34P5K
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reversible: false
kinetic law: MODEL1310110047#
product: MODEL1310110047#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110047#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.7.1.68

metaR r2106
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110047#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110047#

metaR r1147
reversible: true
is: SBO:0000185
product: MODEL1310110047#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110047#
fast: false
is described by: ECO:0000000

metaR RETI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110047#
kinetic law: MODEL1310110047#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
name: retinol isomerase (11-cis)
reactant: MODEL1310110047#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_09fdf16f_7a25_4341_80ad_53d85cd4d363
type: Species
name: ABAT
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:18
initial amount: NaN

metaR C160CRNt
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110047#
modifier: MODEL1310110047#
name: C160 transport into the mitochondria
reactant: MODEL1310110047#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV

metaM stcrn m
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
is: SBO:0000247
initial concentration: 1.0
name: stearoylcarnitine
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: HMDB00848

metaR GLNALANaEx
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
reactant: MODEL1310110047#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110047#
type: Reaction
reversible: false
is described by: ECO:0000269

metaM ksii core4 pre5 g
initial amount: NaN
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 5
is: HMDB00175
is: C00130
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C69H112N6O48X CHARGE: -1
constant: false

metaM CE0849 m
name: cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
constant: false
is: CHEBI:57795
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110047#
product: MODEL1310110047#
reactant: MODEL1310110047#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110047#_f2476001_e567_4ab8_af5c_287d850de445
has only substance units: false
is: SBO:0000252
name: ACSL5
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:51703
type: Species
is: Q9ULC5
initial concentration: NaN

metaR NDPK4n
product: MODEL1310110047#
reversible: true
reactant: MODEL1310110047#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110047#
modifier: MODEL1310110047#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176

metaR HISTAtu
name: Histamine uniport
is: SBO:0000185
modifier: MODEL1310110047#
kinetic law: MODEL1310110047#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
reactant: MODEL1310110047#
reversible: true
is described by: ECO:0000269
product: MODEL1310110047#
type: Reaction

metaR GHMT2r
reversible: true
fast: false
name: glycine hydroxymethyltransferase, reversible
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
modifier: MODEL1310110047#
is version of: http://identifiers.org/ec-code/2.1.2.1
type: Reaction
is described by: ECO:0000269
product: MODEL1310110047#
reactant: MODEL1310110047#
is: SBO:0000176
kinetic law: MODEL1310110047#