http://identifiers.org/biomodels.db/MODEL1310110046#_89e42bb9_6faf_430b_b2c8_65b15cd8c73e
boundary condition: true
initial amount: NaN
is encoded by: hsa:290
constant: false
initial concentration: NaN
type: Species
name: ANPEP
is: SBO:0000252
is: Q59E93
has only substance units: false

metaM o2 e
is: HMDB01377
has only substance units: false
is: C00007
type: Species
initial concentration: 1.0
is: CHEBI:15379
boundary condition: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
name: O2
constant: false

metaR PPA
reversible: false
fast: false
name: inorganic diphosphatase
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
is: SBO:0000176
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110046#
type: Reaction

metaM l2fn2m2masn g
constant: false
is: CHEBI:28067
type: Species
has only substance units: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C68H113N4O49X CHARGE: 0

metaR FBA
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
reactant: MODEL1310110046#
name: fructose-bisphosphate aldolase
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
product: MODEL1310110046#
reversible: true

metaM idp e
name: IDP(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB03335
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_a3fd6735_7453_4f46_85e4_92b7c39a4295
name: SLC4A10
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:57282
is: B7Z1R0
initial concentration: NaN

metaM nadph m
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
initial concentration: 1.0
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
type: Species
boundary condition: false
is: C00005
initial amount: NaN
is: CHEBI:57783
is: HMDB00221

metaR r0610
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110046#
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_a37e8d1d_54fb_45fd_aa58_6c9a4126dd09
is encoded by: hsa:125965
initial amount: NaN
initial concentration: NaN
name: COX6B2
has only substance units: false
constant: false
boundary condition: true
type: Species
is: Q6YFQ2
is: SBO:0000252

metaR FAOXC142C122m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaR r1008
name: Facilitated diffusion
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
is described by: ECO:0000000

metaM ksii core2 pre4 g
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C53H86N4O38X CHARGE: -1
has only substance units: false
is: SBO:0000247
is: HMDB00175
is: CHEBI:58053
is: C00130
name: keratan sulfate II biosynthesis, precursor 4

metaM dctp c
name: dCTP
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: C00458
is: CHEBI:16311
is: HMDB00998
has only substance units: false

metaR DOLP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: dolichol phosphate flippase (liver)
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110046#

metaM glyc R m
is: CHEBI:16659
is: HMDB00139
name: D-glycerate
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaR UREAtm
product: MODEL1310110046#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110046#
fast: false
name: Urea transport via diffusion
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (366.1) SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES:JLR SAB m
is described by: ECO:0000304
kinetic law: MODEL1310110046#

metaR NADPtru
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
name: NADP transporter, endoplasmic reticulum

metaR r0781
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is: SBO:0000176
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR CYSO
product: MODEL1310110046#
modifier: MODEL1310110046#
name: cysteine oxidase
fast: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.13.11.20
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110046#

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR HCO3 CLt
is: SBO:0000185
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
type: Reaction
fast: false
name: bicarbonate transport (Cl-/HCO3- exchange)
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110046#_6ec51c64_94e0_43c6_ab46_1f2c94abfac3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: NAGLU
is: P54802
is encoded by: hsa:4669
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_2a9c6fd7_1f71_4ec7_b4b5_9ea69725678c
is: SBO:0000252
initial amount: NaN
name: NANS
is encoded by: hsa:54187
boundary condition: true
is: Q9NR45
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaR r1007
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
name: Facilitated diffusion
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
reversible: true

metaM tethex3 e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
initial concentration: 1.0
type: Species
name: tetracosahexaenoic acid, n-3
boundary condition: false
has only substance units: false
constant: false
is: HMDB02007

metaR RE3241R
reversible: false
reactant: MODEL1310110046#
type: Reaction
name: RE3241
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110046#
modifier: MODEL1310110046#

metaM xyl D e
initial concentration: 1.0
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15936
has only substance units: false
constant: false

metaR FUMm
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
name: fumarase, mitochondrial
is: SBO:0000176
modifier: MODEL1310110046#
fast: false
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000134
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction

metaM xylu D c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:17140
is: HMDB01644
type: Species
name: D-xylulose

metaR TMDK1m
is described by: ECO:0000269
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
name: thymidine kinase (ATP:thymidine)
reversible: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR r0780
is: SBO:0000176
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
kinetic law: MODEL1310110046#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110046#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_2add1bb1_1468_431d_b2e9_922389f5699b
name: SI
is encoded by: hsa:6476
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: P14410
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM o2 c
is: SBO:0000247
constant: false
is: HMDB01377
type: Species
initial concentration: 1.0
is: C00007
boundary condition: false
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_832fe9fa_28b7_4727_a845_e54c7f4c3640
boundary condition: true
type: Species
initial amount: NaN
name: GCH1
is encoded by: hsa:2643
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: Q8IZH9

http://identifiers.org/biomodels.db/MODEL1310110046#_47d34b37_0b89_4ea9_84b1_f57e744b7160
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5009
is: P00480
name: OTC

metaR PSFLIPm
modifier: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
name: phosphatidylserine flippase
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.1

metaR GLYCTDle
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#
name: difussion of glycerol accross the brush border membrane
is described by: ECO:0000134

metaR AG13T5g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false

metaR AMY2e
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110046#
type: Reaction
fast: false
name: alpha-amylase, extracellular (glygn2 -> glygn4)

metaR r0055
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is version of: http://identifiers.org/ec-code/2.4.2.7
fast: false
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.8
reversible: true
product: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)

metaR PHCDm
is described by: ECO:0000304
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
product: MODEL1310110046#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR RE1527M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reversible: true
name: RE1527
product: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_801e817b_4294_4268_8c05_c469994836a0
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q1LZ56
boundary condition: true
name: SLC36A1
is encoded by: hsa:206358

metaM HC02179 e
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
name: 20-hydroxy-arachidonate
is: SBO:0000247
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306

metaR IDOURte
name: L-iduronate transport, extracellular
reversible: true
product: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction

metaR 5ADTSTSTERONEtr
reactant: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
name: 5 alpha dihydrotesterone intracellular transport
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
fast: false
type: Reaction

metaR C180CPT1
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
name: production of stearoylcarnitine
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
modifier: MODEL1310110046#
product: MODEL1310110046#

metaM glygn2 e
is: HMDB00122
is: CHEBI:4167
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
initial amount: NaN
initial concentration: 1.0
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})

metaR THRSERNaEx
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
is described by: ECO:0000269
type: Reaction
reversible: false

metaM CE0693 m
initial amount: NaN
is: CHEBI:28387
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: 3-oxolaur-6-cis-enoyl-CoA
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110046#_afd42ba0_c033_442c_b005_30545e115cfa
name: LDHC
type: Species
is encoded by: hsa:3948
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM creat m
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
is: HMDB00064
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:16919
name: creatine

metaR r0611
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.3.1
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110046#
fast: false
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
reversible: true

metaR SGALSIDEtg
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
is described by: ECO:0000000
name: sgalside hs intracellular transport

metaR NADtru
reactant: MODEL1310110046#
type: Reaction
name: NAD transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: false

metaM tethex3 c
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
constant: false
is: HMDB02007
is: SBO:0000247
name: tetracosahexaenoic acid, n-3

metaM Rtotal2 e
is: CHEBI:3554
constant: false
is: HMDB00244
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
initial concentration: 1.0
is: SBO:0000247
name: R total 2 position
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00255

metaR RE3566C
is: SBO:0000176
reactant: MODEL1310110046#
fast: false
type: Reaction
kinetic law: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
product: MODEL1310110046#
name: RE3566

http://identifiers.org/biomodels.db/MODEL1310110046#_955f2586_a7fa_4e8b_ab58_1bcaf9ed4b09
type: Species
has only substance units: false
name: BDH1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:622

http://identifiers.org/biomodels.db/MODEL1310110046#_25e133bb_2306_42e3_9e84_656fea369a46
name: SLC16A10
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:117247
boundary condition: true
is: Q8TF71
is: SBO:0000252

metaR DPPS
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
name: decaprenyl synthase
type: Reaction
product: MODEL1310110046#
fast: false
is: SBO:0000176
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110046#

metaR PI34P5K
fast: false
is: SBO:0000176
kinetic law: MODEL1310110046#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_984fdfe8_ea55_47c8_b0e8_afd0eb881dd0
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: B4DNK4
is encoded by: hsa:5315
constant: false
name: PKM2
is: SBO:0000252

metaR FAOXC221C201x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR C180CPT2
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110046#
reversible: false
name: carnitine O-stearoyl transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269

metaM 12ppd R c
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
is: SBO:0000247
is: CHEBI:28972
type: Species
name: (R)-propane-1,2-diol
is: HMDB01881
boundary condition: false
has only substance units: false

metaM gdpddman c
is: SBO:0000247
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57964
has only substance units: false
is: HMDB01346
boundary condition: false
type: Species

metaR KSII CORE2tly
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110046#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM tststerones e
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB02833
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
constant: false
type: Species
name: testosterone sulfate
initial amount: NaN
initial concentration: 1.0

metaR CO2tp
name: CO2 peroxisomal transport
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR PI5P3K
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-5-phosphate 3-kinase
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.137
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b3a890c9_6f3b_4b12_a76a_9d7fda914457
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5160
initial concentration: NaN
is: P08559
constant: false
has only substance units: false
name: PDHA1
type: Species

metaR BPNT
is: SBO:0000176
name: 3',5'-bisphosphate nucleotidase
modifier: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.7
fast: false
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:

metaM HC02179 c
name: 20-hydroxy-arachidonate
is: CHEBI:34306
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM cs e deg1 l
is: SBO:0000247
type: Species
is: CHEBI:57737
is: HMDB00868
has only substance units: false
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
initial concentration: 1.0
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
constant: false
initial amount: NaN

metaR GLYCLTtp
fast: false
name: glycolate transport into peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
is: SBO:0000185
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR r1563
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_399a2726_ef04_4e3a_8372_1e1b83e063ef
is: B7Z7I0
name: TKTL1
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:8277
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_116c02a5_f91b_4242_8b08_f346f07f2c6a
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:25769
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC24A2
constant: false
is: Q9UI40
type: Species

metaM ametam c
name: S-Adenosylmethioninamine
is: C01137
is: HMDB00988
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57443
boundary condition: false
has only substance units: false

metaM tym c
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
name: tyraminium
is: HMDB00306
is: SBO:0000247
is: CHEBI:327995
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaR OCD11COACPT1
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_cd1ddfd0_497f_43f8_9f19_b2875d83f1d2
is: Q99714
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: HSD17B10
has only substance units: false
is encoded by: hsa:3028
constant: false
boundary condition: true
type: Species

metaR r0679
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110046#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
fast: false

metaR ME1m
is version of: http://identifiers.org/ec-code/1.1.1.38
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
name: malic enzyme (NAD), mitochondrial
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_752e2489_01ec_45a2_be63_5ff8783b0611
initial concentration: NaN
constant: false
is encoded by: hsa:10327
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: AKR1A1

metaR r1562
fast: false
product: MODEL1310110046#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR r0784
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.1.38
product: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
modifier: MODEL1310110046#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_a7b57934_62bd_45f5_a814_c0ca581a2c76
has only substance units: false
initial amount: NaN
is encoded by: hsa:197257
constant: false
name: LDHD
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaM nadp r
constant: false
is: C00006
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
is: HMDB00217
has only substance units: false
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR BTNPLm
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
product: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10

metaM lac L e
is: CHEBI:16651
is: SBO:0000247
is: HMDB00190
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

http://identifiers.org/biomodels.db/MODEL1310110046#_9df1c94d_9404_4df6_a73c_34cfa91d091e
initial amount: NaN
has only substance units: false
name: GALNT1
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: Q10472
is: SBO:0000252
is encoded by: hsa:2589

metaM Rtotal2 c
is: HMDB01564
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57876
type: Species
name: R total 2 position
has only substance units: false
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1

metaM damp c
is: CHEBI:58245
is: HMDB00905
initial amount: NaN
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: SBO:0000247
constant: false
name: dAMP(2-)
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM tststerones c
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
is: SBO:0000247
name: testosterone sulfate
is: HMDB02833
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaM xyl D l
is: CHEBI:15936
initial concentration: 1.0
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM idp c
boundary condition: false
name: IDP(3-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
is: HMDB03335
has only substance units: false
is: CHEBI:58280
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d32e81ed_3317_4f51_bff0_c48861c0ad57
initial amount: NaN
is: O75874
is: SBO:0000252
name: IDH1
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:3417
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_1f8cfd71_8a65_47e2_b67c_28982c34d7a0
has only substance units: false
boundary condition: true
is: P09622
constant: false
is encoded by: hsa:1738
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: DLD

metaM lnlccrn m
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
is: HMDB06469
name: Linoleyl carnitine
type: Species
initial amount: NaN

metaR r0783
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
fast: false
modifier: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_c371a71d_67d0_4c50_8314_33364cb65776
type: Species
name: PIK3C2A
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O00443
constant: false
is encoded by: hsa:5286
boundary condition: true

metaR r1561
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000

metaR ADNCYC
is: SBO:0000176
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
name: adenylate cyclase
is version of: http://identifiers.org/ec-code/4.6.1.1
fast: false
reactant: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_f2e992aa_f705_406f_a1eb_d586b2a464c1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:29880
name: ALG5
boundary condition: true
initial amount: NaN
is: Q9Y673
initial concentration: NaN
constant: false
type: Species

metaR ILETA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110046#
name: isoleucine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_bf96f8f7_3338_4c51_a2c3_92a67fccf528
has only substance units: false
constant: false
initial concentration: NaN
is: Q4J699
boundary condition: true
is encoded by: hsa:491
is: SBO:0000252
name: ATP2B2
type: Species
initial amount: NaN

metaR CO2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
name: CO2 transport (diffusion), mitochondrial
type: Reaction
reversible: true

metaM hco3 m
constant: false
name: Bicarbonate
is: HMDB00595
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: C00288
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544

metaR FATP5t
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.7
is described by: ECO:0000269
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1699c429_49d2_4123_8a3b_b5d0c54bc666
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:5152
initial concentration: NaN
name: PDE9A
constant: false
boundary condition: true
is: SBO:0000252

metaR BHBt
fast: false
kinetic law: MODEL1310110046#
name: (R)-3-Hydroxybutanoate transport via H+ symport
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
type: Reaction
is: SBO:0000185
reversible: true

metaR r0782
is: SBO:0000176
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271

metaM hyptaur c
is: CHEBI:16668
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
constant: false
name: Hypotaurine
is: HMDB00965
has only substance units: false
type: Species

metaR r1560
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM trdrd m
name: Reduced thioredoxin
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial amount: NaN
is: CHEBI:15967
is: SBO:0000247
type: Species
constant: false

metaR CYTK5n
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
name: cytidylate kinase (CMP),nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM nadph r
is: C00005
has only substance units: false
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
is: SBO:0000247
is: CHEBI:57783
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM lac L c
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
is: HMDB00190
initial concentration: 1.0
has only substance units: false
is: CHEBI:16651
boundary condition: false
name: (S)-lactate
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_7712f896_2c51_4f62_886f_7b740902ed32
has only substance units: false
name: DPYS
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: Q14117
is encoded by: hsa:1807
boundary condition: true
constant: false

metaM dolmanp U r
is: CHEBI:15809
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human uterine homolog
constant: false
has only substance units: false

metaR r0361
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (5009.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.3.3
kinetic law: MODEL1310110046#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110046#
modifier: MODEL1310110046#

metaM nadp m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00006
has only substance units: false
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
constant: false

metaR ALAGLNexR
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
kinetic law: MODEL1310110046#
name: L-alanine/glutamine reversible exchange
fast: false
product: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
type: Reaction

metaR NACHEX9ly
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000000

metaR r1454
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
reactant: MODEL1310110046#
reversible: false
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_5c2d96b2_2f9c_4656_a582_61cc4aa5bd15
type: Species
is encoded by: hsa:1503
is: SBO:0000252
initial amount: NaN
is: P17812
has only substance units: false
initial concentration: NaN
constant: false
name: CTPS1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_5ac9b45f_2f0b_40f1_8e5b_c2fe3a5fdf3b
has only substance units: false
boundary condition: true
name: B3GALT5
constant: false
is encoded by: hsa:10317
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9Y2C3

metaR r0789
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_9a9ff7cf_0ad7_4a54_8732_285fb836349f
boundary condition: true
name: SLC34A2
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10568
is: O95436
constant: false
is: SBO:0000252
has only substance units: false

metaR ALADGLNexR
modifier: MODEL1310110046#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110046#
name: L-alanine/glutamine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110046#_b48f99ab_1e26_4411_afc8_094639c6b5a3
initial amount: NaN
constant: false
name: CLYBL
is encoded by: hsa:171425
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM ppi x
name: Diphosphate
is: HMDB00250
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR FAOXC165C164m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaM o2 m
is: SBO:0000247
initial concentration: 1.0
name: O2
initial amount: NaN
is: CHEBI:15379
is: C00007
is: HMDB01377
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species

metaM 3hmp m
boundary condition: false
initial amount: NaN
is: HMDB00023
type: Species
name: 3-hydroxy-2-methylpropanoate
initial concentration: 1.0
constant: false
is: CHEBI:11805
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: SBO:0000247
has only substance units: false

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

metaM gtp c
is: CHEBI:37565
type: Species
is: C00044
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: GTP
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b89e2963_612e_4c8b_8e95_d7fda02cf7d4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8654
type: Species
initial amount: NaN
constant: false
name: PDE5A
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_007da460_81d2_4ae5_bb8d_69bb3ec0249f
boundary condition: true
initial concentration: NaN
name: PKM2
is: P14618
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:5315

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM idp n
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
name: IDP(3-)
initial concentration: 1.0
type: Species
is: HMDB03335
boundary condition: false
is: CHEBI:58280
constant: false
is: SBO:0000247

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR r0360
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.16
is: SBO:0000176

metaM 13 cis retn r
type: Species
constant: false
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
has only substance units: false
is: HMDB06219
boundary condition: false
is: http://identifiers.org/pubchem.compound/7847414
is: D00348
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM lnlc c
initial concentration: 1.0
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
initial amount: NaN
name: linoleate
is: CHEBI:30245
boundary condition: false
has only substance units: false
is: HMDB00673
constant: false

metaR C4DCCACT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaM 56dthm c
is: HMDB00079
initial concentration: 1.0
boundary condition: false
name: 5,6-dihydrothymine
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: SBO:0000247
is: CHEBI:27468

metaR r1453
is described by: ECO:0000000
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
kinetic law: MODEL1310110046#
type: Reaction
reversible: true

metaM etfox m
is: CHEBI:16469
notes: FORMULA: R CHARGE: 0
constant: false
name: Electron transfer flavoprotein oxidized
has only substance units: false
boundary condition: false
is: HMDB00151
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN

metaR r0788
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.13.15
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110046#

metaM HC00718 c
is: CHEBI:57781
boundary condition: false
type: Species
name: N-methylethanolaminium phosphate(1-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_b23097ee_000a_4b46_9c9d_ba58f0c238a9
type: Species
name: COX5A
is encoded by: hsa:9377
constant: false
initial amount: NaN
is: P20674
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM dhf c
is: HMDB01056
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
name: 7,8-Dihydrofolate
is: SBO:0000247
boundary condition: false
is: CHEBI:57451
initial amount: NaN
has only substance units: false
is: C00415
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_b6882513_f17b_4328_9cae_16bb17a7c9f9
name: NDUFA7
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4701
boundary condition: true
is: Q6FG42
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d72a2360_e1ce_4609_86f9_ced8a473b09d
boundary condition: true
type: Species
is: H0UI06
name: COX7A2
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1347
initial amount: NaN
is: SBO:0000252

metaM glu L c
boundary condition: false
type: Species
name: L-glutamate(1-)
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
is: CHEBI:29985

http://identifiers.org/biomodels.db/MODEL1310110046#_ae04ea2b_b83f_4c70_b0e2_ddd7bd442dea
has only substance units: false
is encoded by: hsa:11112
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: HIBADH
boundary condition: true
constant: false
is: P31937

http://identifiers.org/biomodels.db/MODEL1310110046#_fa8b402d_fb3a_401f_995e_3f85d0509fa6
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM glyc R c
has only substance units: false
initial amount: NaN
name: D-glycerate
constant: false
is: CHEBI:16659
is: SBO:0000247
is: HMDB00139
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
type: Species

metaR C3STDH1r
is version of: http://identifiers.org/ec-code/1.1.1.170
product: MODEL1310110046#
type: Reaction
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ

metaM orot c
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00295
boundary condition: false
is: HMDB00226
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
name: Orotate
type: Species
has only substance units: false
is: SBO:0000247

metaM HC01842 c
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
name: Phosphodimethylethanolamine
is: CHEBI:31997
is: SBO:0000247
type: Species
initial amount: NaN

metaR FAOXC15C13m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR FAOXC18480m
product: MODEL1310110046#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR r0787
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reactant: MODEL1310110046#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:

metaR 2HCO3 NAt
kinetic law: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reversible: true
is: SBO:0000185
modifier: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d33d70cc_1736_4f1a_bbfb_9369f424934b
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2108
name: ETFA
is: P13804
constant: false
type: Species
initial concentration: NaN

metaM gtp e
constant: false
has only substance units: false
name: GTP(4-)
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
is: SBO:0000247
is: CHEBI:37565

http://identifiers.org/biomodels.db/MODEL1310110046#_dea831f4_5917_47ea_9931_0dcbedd3c72b
constant: false
boundary condition: true
has part: P15531
initial amount: NaN
is encoded by: hsa:4831
type: Species
initial concentration: NaN
has part: P22392
has only substance units: false
is: SBO:0000297
is encoded by: hsa:4830
name: NME1:NME2

http://identifiers.org/biomodels.db/MODEL1310110046#_634bfa2c_d0cb_4113_a1e0_a567109a2031
constant: false
has only substance units: false
is: Q9UGQ3
initial amount: NaN
boundary condition: true
is encoded by: hsa:11182
is: SBO:0000252
initial concentration: NaN
name: SLC2A6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_b4105873_ce5f_49b7_b995_b7640f034fd1
constant: false
is encoded by: hsa:443
is: Q6FH48
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ASPA

http://identifiers.org/biomodels.db/MODEL1310110046#_4277eaff_cf10_47e3_829e_df6ed61f96ca
boundary condition: true
initial amount: NaN
is: Q86YN1
is encoded by: hsa:57171
has only substance units: false
name: DOLPP1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_789f0083_60c7_42a5_b470_54f31e45861b
boundary condition: true
name: SLC6A4
constant: false
is encoded by: hsa:6532
type: Species
is: P31645
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR CO2ter
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110046#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
name: CO2 endoplasmic reticular transport via diffusion

metaR r0672
modifier: MODEL1310110046#
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110046#
type: Reaction
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:

metaM o2 r
has only substance units: false
boundary condition: false
name: O2
type: Species
initial amount: NaN
is: SBO:0000247
is: C00007
is: CHEBI:15379
is: HMDB01377
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0

metaR r0365
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
reversible: false
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
fast: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#

metaR GTHO
is: SBO:0000176
product: MODEL1310110046#
reactant: MODEL1310110046#
name: glutathione oxidoreductase
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
type: Reaction
is described by: ECO:0000254
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#

metaM glu L e
constant: false
is: HMDB00148
name: L-glutamate(1-)
boundary condition: false
is: CHEBI:29985
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
initial amount: NaN

metaR NTD2m
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
fast: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110046#
reversible: false
name: 5'-nucleotidase (UMP), mitochondrial
is described by: ECO:0000269

metaM ksi deg30 l
is: CHEBI:12936
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: HMDB00143
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 30

metaR r1117
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110046#

metaM orot e
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:30839
constant: false
is: HMDB00226
is: SBO:0000247
name: orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
initial amount: NaN

metaM cs e deg3 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
constant: false
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: HMDB00127
type: Species
is: CHEBI:15748
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR CH25H
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: cholesterol 25-hydroxylase
product: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.99.38

http://identifiers.org/biomodels.db/MODEL1310110046#_5da8bbe8_2fd8_4716_8cb4_7ff6557b0f60
name: ATP1B1
is: A3KLL5
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:481
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_57770021_8ed4_4edb_9c1b_6c7019817bc2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: HIBCH
is encoded by: hsa:26275
is: Q6NVY1

metaR FAOXC1811602m
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: Beta oxidation fatty acid
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false

metaM nadph x
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57783
is: C00005
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_6d68623c_d4c2_46a2_b726_618bb442bb35
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:D87002
boundary condition: true
constant: false
name: _D87002_1_m
initial amount: NaN
type: Species

metaM lnlccoa m
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB01064
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
name: linoleic coenzyme A
initial amount: NaN

metaR r1116
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000000
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1

http://identifiers.org/biomodels.db/MODEL1310110046#_e8730747_c076_4172_9869_ff6b5ddb7a4c
is encoded by: hsa:126
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
has part: P00326
constant: false
initial amount: NaN
name: ADH1B:ADH1C
is: SBO:0000297

metaR FAOXC2242046m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_ff5662fa_24cc_4f44_bcb5_df9c0fa99dfd
name: ALDH3B2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:222
is: P48448

http://identifiers.org/biomodels.db/MODEL1310110046#_7c151768_f83a_4e30_9221_38e3a00a4173
initial concentration: NaN
initial amount: NaN
name: SDHC
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6391
type: Species
is: Q99643
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_32edf407_7ee0_4bc3_83b1_148f8099da2b
boundary condition: true
constant: false
is encoded by: hsa:6515
initial concentration: NaN
is: SBO:0000252
name: SLC2A3
is: P11169
type: Species
has only substance units: false
initial amount: NaN

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_a155ca89_df31_4466_a306_fe65cb04770c
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4125
is: SBO:0000252
has only substance units: false
constant: false
is: O00754
name: MAN2B1
initial amount: NaN

metaR KHte
kinetic law: MODEL1310110046#
fast: false
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: KHte

metaR r0051
modifier: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
fast: false
reversible: true
is: SBO:0000176

metaR P45027A14m
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
modifier: MODEL1310110046#
type: Reaction
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reversible: false
is: SBO:0000176

metaM mi4p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
type: Species
initial concentration: 1.0
is: CHEBI:58469
boundary condition: false
is: SBO:0000247
name: 1D-myo-inositol 4-phosphate(2-)
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01313

metaR FBP
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: fructose-bisphosphatase
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.11

metaM ksi deg17 l
type: Species
constant: false
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 17
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial amount: NaN
is: CHEBI:12936

metaM gar c
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: SBO:0000247
is: HMDB02022
is: CHEBI:58457
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
initial concentration: 1.0
is: C03838
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_55484d78_5756_4287_bafe_7abc533589a0
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5295
constant: false
type: Species
boundary condition: true
name: PIK3R1
has only substance units: false
initial concentration: NaN
is: E7EX19

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_30754046_1a8c_46b8_af2d_f097b3cab963
has only substance units: false
name: UPP2
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:151531
is: O95045
initial amount: NaN
constant: false
is: SBO:0000252

metaR PPM
reactant: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/5.4.2.2
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000176
name: phosphopentomutase

metaR G14T18g
reactant: MODEL1310110046#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#

metaR XOLTRIOLtm
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
fast: false
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110046#

metaR TCYNTt
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is: SBO:0000185

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false
is: SBO:0000176
name: glutathione peroxidase
modifier: MODEL1310110046#
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.12
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_154c6a2a_1798_4a86_bb55_8e4ecd101e24
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6539
initial concentration: NaN
boundary condition: true
name: SLC6A12
constant: false
initial amount: NaN
type: Species
is: P48065

metaM lnlc e
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245
is: HMDB00673
initial concentration: 1.0
boundary condition: false
name: linoleate
is: SBO:0000247

metaM HC01162 c
type: Species
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial amount: NaN
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
constant: false
is: CHEBI:58376
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM 34dhmald c
name: 3,4-Dihydroxymandelaldehyde
type: Species
is: C05577
is: http://identifiers.org/pubchem.compound/7903
initial concentration: 1.0
constant: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06242

http://identifiers.org/biomodels.db/MODEL1310110046#_e3d357be_a8cb_406d_8180_911738782871
has only substance units: false
initial amount: NaN
name: AK5
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:26289
is: SBO:0000252

metaM dctp n
is: CHEBI:16311
is: SBO:0000247
is: HMDB00998
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
name: dCTP
is: C00458

metaM o2 n
initial concentration: 1.0
constant: false
type: Species
is: HMDB01377
initial amount: NaN
name: dioxygen
is: CHEBI:15379
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_5620f5a1_e24b_487e_982a_8fceee2e5f4c
is encoded by: hsa:3636
initial concentration: NaN
type: Species
is: O15357
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: INPPL1
has only substance units: false
constant: false

metaR r0502
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.113
type: Reaction
fast: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_8ac7c86b_5468_45ab_a466_fa0c004cd972
boundary condition: true
name: DLD:DLST:OGDH:PDHX
initial concentration: NaN
initial amount: NaN
has part: P36957
is: SBO:0000297
has part: P09622
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4967
is encoded by: hsa:8050
has part: Q02218
is encoded by: hsa:1738
has part: O00330
is encoded by: hsa:1743

metaR TAUPAT1c
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

metaM dcsptn1crn m
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
is: HMDB06321
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial amount: NaN
has only substance units: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM dudp m
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
boundary condition: false
has only substance units: false
name: dUDP(3-)
initial amount: NaN
is: CHEBI:60471

metaR r0504
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
reactant: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10

metaM arab L e
is: SBO:0000247
name: L-arabinose
type: Species
is: CHEBI:30849
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00646

metaR RE3273C
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
name: RE3273

metaM fn2m2masn g
type: Species
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
boundary condition: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32984
is: SBO:0000247
constant: false

metaR 3AIBTm
is version of: http://identifiers.org/ec-code/2.6.1.19
reactant: MODEL1310110046#
reversible: true
name: L-3-aminoisobutyrate transaminase, mitochondrial
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110046#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaM nrpphrsf e
is: SBO:0000247
initial concentration: 1.0
is: HMDB02062
type: Species
constant: false
has only substance units: false
boundary condition: false
name: Sulfate derivative of norepinephrine
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/123747

http://identifiers.org/biomodels.db/MODEL1310110046#_a1f69025_1799_43a1_a2d4_ca140012ad58
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5152
name: PDE9A
initial amount: NaN
has only substance units: false
constant: false

metaR FAOXC2031836m
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
fast: false
name: Beta oxidation of fatty acid
reversible: false

metaR PLA2 2
is version of: http://identifiers.org/ec-code/3.1.1.4
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176
modifier: MODEL1310110046#
name: phospholipase A2
reversible: false
type: Reaction

metaM core2 g
has only substance units: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: CHEBI:15876
is: SBO:0000247
constant: false
boundary condition: false
name: Core 2
type: Species
initial amount: NaN
initial concentration: 1.0

metaM tetpent6 e
is: HMDB06322
initial amount: NaN
has only substance units: false
name: tetracosapentaenoic acid, n-6
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false

metaR G14T19g
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110046#

metaR HESTRATRIOLtr
product: MODEL1310110046#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
name: hydroxylated estrogen derivative transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaM tridcoa m
name: tridecanoylcoa
is: SBO:0000247
initial amount: NaN
is: HMDB13109
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4

metaM ach c
name: acetylcholine
is: HMDB00895
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaM dhf m
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01056
has only substance units: false
type: Species
name: dihydrofolate(2-)

metaR r1742
name: Y+LAT2 Utilized transport
product: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
is: SBO:0000185

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaM 42A3HP24DB c
has only substance units: false
is: http://identifiers.org/pubchem.compound/7956
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
type: Species
is: C05645
constant: false
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial amount: NaN
initial concentration: 1.0
is: HMDB04083
is: SBO:0000247
boundary condition: false

metaM CE4790 m
has only substance units: false
is: SBO:0000247
is: CHEBI:57923
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

metaR r0680
is: SBO:0000176
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
fast: false
type: Reaction

metaM xoldioloneh c
is: HMDB06887
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
is: SBO:0000247
is: CHEBI:2288

http://identifiers.org/biomodels.db/MODEL1310110046#_4625607e_2e9f_407c_b577_a3408126276f
is: Q99424
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: ACOX2
is encoded by: hsa:8309
initial concentration: NaN
has only substance units: false
type: Species

metaR r1745
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false

metaM galside hs l
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine

metaM nrpphrsf c
has only substance units: false
name: Sulfate derivative of norepinephrine
is: HMDB02062
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/123747
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR RE1796M
name: RE1796
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: true
product: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#

metaR GGH 10FTHF7GLUe
kinetic law: MODEL1310110046#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
modifier: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_05f6e514_af71_4ba3_8116_831dc22a1bfe
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AA532636
name: _AA532636_1_m
constant: false
initial concentration: NaN

metaM gtp m
name: GTP
is: C00044
constant: false
is: HMDB01273
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0

metaR r0354
reactant: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false

metaM hexdectecoa m
has only substance units: false
boundary condition: false
constant: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
name: 2,4,7,10-hexadecatetraenoylcoa
is: SBO:0000247
is: HMDB02288

metaM tetpent6 c
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB06322
has only substance units: false
name: tetracosapentaenoic acid, n-6

metaR RETH
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.3
fast: false
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: retinyl ester hydrolase

http://identifiers.org/biomodels.db/MODEL1310110046#_628e0b35_8e19_4428_9862_cd7d09e3682f
has only substance units: false
initial concentration: NaN
is encoded by: hsa:290
boundary condition: true
name: ANPEP
type: Species
constant: false
is: Q59E93
is: SBO:0000252
initial amount: NaN

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR PALFATPtc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaM CE4794 m
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:57923
type: Species
name: cis-6-dodecenoyl-CoA

metaR AG13T12g
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
is: SBO:0000176

metaM CE5126 x
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:12947
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
name: (2R)-pristanoyl-CoA

metaM dudp n
initial concentration: 1.0
is: HMDB01000
has only substance units: false
is: SBO:0000247
name: dUDP(3-)
boundary condition: false
constant: false
type: Species
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN

metaR NAtx
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110046#
fast: false
type: Reaction
is: SBO:0000185
name: sodium transport via diffusion (perioxisome)
reactant: MODEL1310110046#
reversible: true

metaR 3AIBtm
is: SBO:0000185
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 3-amino-isobutyrate transport, mitochondrial
is described by: ECO:0000000
product: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_f7f26115_5d27_4510_842d_55170c3828a4
is: SBO:0000252
is encoded by: hsa:5149
constant: false
name: PDE6H
type: Species
boundary condition: true
initial concentration: NaN
is: Q13956
has only substance units: false
initial amount: NaN

MODEL1310110046#
species: metaM c6crn e
species: metaM prgstrn e
species: metaM succ x
species: metaM 4mop c
species: metaM acnacngalgbside hs c
species: metaM 3hdcoa m
species: metaM HC01401 x
species: metaM chsterol c
species: metaM pail34p hs c
species: metaM adpcoa x
species: metaM 25aics c
species: metaM 4hpro LT m
species: metaM adp r
species: metaM prgnlones c
species: metaM his L e
species: metaM ksi g
stoichiometry: 5.0
species: metaM 5HPET c
species: metaM pa hs c
species: metaM ksii core4 pre6 g
species: metaM gthox m
species: metaM core6 l
species: metaM hexe3coa m
species: metaM didp n
species: metaM ppi x
species: metaM so4 m
species: metaM bhb m
species: metaM ump c
species: metaM ksi pre6 g
species: metaM HC01399 m
species: metaM gua e
species: metaM hxan e
species: metaM ksi deg8 l
species: metaM m3mpdol L c
species: metaM phytcoa c
species: metaM 5aop m
name: GUCY1A3:GUCY1B3
species: metaM uacgam g
species: metaM udp n
species: metaM atp n
species: metaM icit m
species: metaM glu L m
species: metaM ksi pre34 g
species: metaM odecrn c
species: metaM dnad c
species: metaM tethex3 e
species: metaM apoC Lys c
species: metaM gmp c
species: metaM dcdp n
species: metaM coa n
species: metaM adn c
species: metaM oaa c
species: metaM hs deg14 l
species: metaM fuc L c
species: metaM nrvnc e
species: metaM C05965 e
species: metaM CE5121 m
species: metaM sbt D e
species: metaM pail3p hs c
species: metaM phyt2ohcoa x
species: metaM g3m8mpdol L r
species: metaM thyox L c
species: metaM pan4p m
species: metaM 4mptnl m
species: metaM ru5p D c
species: metaM ksi pre23 g
species: metaM tchola e
species: metaM ksii core2 pre5 g
species: metaM o2 r
species: metaM HC00695 m
species: metaM m2gacpail hs r
species: metaM CE4790 m
species: metaM bilirub e
species: metaM leuktrC4 e
species: metaM f1a l
species: metaM hs deg8 l
species: metaM dheas c
species: metaM fpram c
species: metaM ksii core2 deg7 l
species: metaM adrncrn m

metaM gtp n
name: GTP(4-)
boundary condition: false
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: HMDB01273
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

metaR r0355
product: MODEL1310110046#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
reversible: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR RBTt
is described by: ECO:0000000
type: Reaction
name: ribitol transport via passive diffusion
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: false
is: SBO:0000185

metaR 5ADTSTSTERONEte
is: SBO:0000185
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
fast: false
name: 5 alpha dihydrotesterone transport

http://identifiers.org/biomodels.db/MODEL1310110046#_9dedcb01_9a85_483e_a206_05cb1cbb2587
boundary condition: true
is: Q92685
is: SBO:0000252
name: ALG3
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:10195

http://identifiers.org/biomodels.db/MODEL1310110046#_a4da73d7_36ca_49e7_9b64_0e9cc282f993
is: Q8NFW8
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: CMAS
type: Species
is encoded by: hsa:55907
has only substance units: false
constant: false

metaR RE2269E
kinetic law: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
is described by: ECO:0000000
name: RE2269
is version of: http://identifiers.org/ec-code/3.4.21.39
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction

metaM ala B e
name: beta-alanine
is: HMDB00056
is: CHEBI:16958
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_8b75f6c7_3b3a_4d9e_b762_6353c67fb1a4
has only substance units: false
is: Q9BVK2
constant: false
initial amount: NaN
boundary condition: true
name: ALG8
initial concentration: NaN
is encoded by: hsa:79053
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_1e2d9c9d_fc14_49af_babe_74f17aac2575
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:622
type: Species
name: BDH1
initial concentration: NaN

metaR LINKDEG1ly
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110046#
reversible: false
name: degradation of proteoglycan linkage region, lysosomal
fast: false
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_918f6d98_7aa4_4b88_9b89_9f14bd45a56f
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: RHAG
type: Species
is: Q96E98
is encoded by: hsa:6005
boundary condition: true
is: SBO:0000252

metaM glygn4 e
boundary condition: false
has only substance units: false
constant: false
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H31O16X CHARGE: 0
initial amount: NaN
type: Species
is: CHEBI:4167
is: HMDB00122

metaM Lcyst c
name: L-cysteate(1-)
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58090
is: HMDB02757
has only substance units: false
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR G6PPer
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
name: glucose-6-phosphate phosphatase, edoplasmic reticular
modifier: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.9

metaR GTHPm
modifier: MODEL1310110046#
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.15
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
type: Reaction

metaM ribflv c
boundary condition: false
is: C00255
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Riboflavin
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
is: HMDB00244
is: CHEBI:3554

metaM lanost r
is: CHEBI:16521
boundary condition: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
has only substance units: false
name: lanosterol
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01251
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_a76f4b9f_8f16_47e7_aad4_68c969854fde
is: SBO:0000252
is: Q86YW0
initial concentration: NaN
has only substance units: false
constant: false
name: PLCZ1
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:89869

http://identifiers.org/biomodels.db/MODEL1310110046#_375a2af7_912d_4495_815c_2a19074b8d1e
is encoded by: hsa:4696
is: SBO:0000252
is: O95167
name: NDUFA3
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_286004d6_d486_4291_ae28_953a727dc042
is encoded by: hsa:10870
is: SBO:0000252
is: Q9UBK5
constant: false
boundary condition: true
name: HCST
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_622ec819_3866_44f9_b148_bdccb33016f3
has only substance units: false
is encoded by: hsa:H17063
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: _H17063_1_c
is: SBO:0000252
initial concentration: NaN

metaR FACOAL40im
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
reversible: false
type: Reaction
fast: false
is: SBO:0000176
name: fatty-acid--CoA ligase (butanoate), mitochondrial
reactant: MODEL1310110046#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (116285.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES:JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD
is version of: http://identifiers.org/ec-code/6.2.1.2

metaM glu L m
is: CHEBI:29985
name: L-glutamate(1-)
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
is: HMDB00148
constant: false

metaR ACITL
is: SBO:0000176
product: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.8
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: ATP-Citrate lyase

metaR BDMT L
is version of: http://identifiers.org/ec-code/2.4.1.142
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
reactant: MODEL1310110046#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110046#
fast: false

metaR FAOXC226m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaM ac m
constant: false
boundary condition: false
name: acetate
is: HMDB00042
has only substance units: false
is: SBO:0000247
is: CHEBI:30089
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaM gdpmann c
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: HMDB01163
name: GDP-alpha-D-mannose(2-)
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57527

metaR SUCRe
is version of: http://identifiers.org/ec-code/3.2.1.20
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.10
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
modifier: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
name: sucrose hydrolyzing enxyme, extracellular
is: SBO:0000176
kinetic law: MODEL1310110046#

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM arab L c
name: L-arabinose
is: CHEBI:30849
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
boundary condition: false
has only substance units: false
type: Species
is: HMDB00646
constant: false
initial amount: NaN
is: SBO:0000247

metaR VITD3t2
fast: false
is: SBO:0000185
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reversible: false
is described by: ECO:0000000
name: Vitamin D3 uptake
product: MODEL1310110046#
type: Reaction

metaR PA HSter
name: phosphatidate scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110046#

metaR FAOXC165C164x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_0e1a4e7a_e988_400f_a44c_3cbac440d1bd
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM adpcoa c
boundary condition: false
initial amount: NaN
constant: false
is: C14143
initial concentration: 1.0
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
name: adipoylcoa
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB04047

http://identifiers.org/biomodels.db/MODEL1310110046#_35a07e3c_e940_4549_86a7_bf4925b58851
constant: false
type: Species
name: HK1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3098
has only substance units: false
initial amount: NaN
is: A8K7J7
is: SBO:0000252

metaR FAOXC142C122x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaR TMNDNCt
reversible: true
type: Reaction
name: fatty acid transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM core3 g
initial concentration: 1.0
name: Core 3
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
is: CHEBI:16250
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM ribflv e
is: C00255
initial amount: NaN
type: Species
is: CHEBI:3554
name: Riboflavin
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00244
is: SBO:0000247
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0

metaR ACGALtly
kinetic law: MODEL1310110046#
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
name: N-acetyl-galactosamine lysosomal efflux
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaM udpg c
name: UDPglucose
is: C00029
is: HMDB00286
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:58367

http://identifiers.org/biomodels.db/MODEL1310110046#_c84b836c_4fe6_4d52_a609_f850fbb8a286
constant: false
is: Q9Y633
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PDE1A
type: Species
initial amount: NaN
is encoded by: hsa:5136

metaM hcys L c
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: SBO:0000247
constant: false
name: L-homocysteine
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00742
is: CHEBI:17588

metaR ASPTA
reversible: true
kinetic law: MODEL1310110046#
name: aspartate transaminase
fast: false
modifier: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
reactant: MODEL1310110046#
is: SBO:0000176

metaM ksi pre26 g
is: CHEBI:28067
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 26

metaM galgluside hs g
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:58223
name: galactosyl glucosyl ceramide
is: SBO:0000247
initial concentration: 1.0
is: C00015
constant: false
is: HMDB00295
initial amount: NaN

metaR 2HBO
kinetic law: MODEL1310110046#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
fast: false
reversible: true
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#

metaR HSAT3ly
kinetic law: MODEL1310110046#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reversible: false
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_758a47f7_d27d_4096_b4d4_0480538ff772
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CHST3
initial concentration: NaN
constant: false
boundary condition: true
is: Q7LGC8
is encoded by: hsa:9469
type: Species

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_a14839e6_0187_4e42_9bf7_ee57bd22efd2
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: _M68895_1_c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:M68895

metaR r1010
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110046#
name: Postulated transport reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
fast: false

metaR r1011
type: Reaction
name: Transport reaction
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reversible: false
product: MODEL1310110046#

metaR ACNAMlt
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110046#
name: N-acetylneuraminate transport into lysososme
fast: false
is: SBO:0000185
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110046#_52d70e60_f0c3_4de4_b7f4_d102d41d4ec5
is encoded by: hsa:2878
has only substance units: false
is: P22352
is: SBO:0000252
name: GPX3
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_618d9ae0_1426_4bd7_a9af_2015a853b8f5
is: Q13613
has only substance units: false
initial amount: NaN
name: MTMR1
is encoded by: hsa:8776
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_5075b5a0_4c48_46ab_8e68_fe8e81e61855
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ACAT1
initial concentration: NaN
is encoded by: hsa:38
type: Species
is: P24752
has only substance units: false

metaM g6p c
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:61548
is: HMDB01401
name: D-Glucose 6-phosphate
initial amount: NaN
is: SBO:0000247

metaR r1554
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_88f673fd_96e0_4394_94bb_a8245bbd1173
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2348
name: FOLR1
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaM cholcoa c
type: Species
has only substance units: false
name: choloyl-CoA(4-)
is: CHEBI:57373
is: HMDB01374
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: SBO:0000247

metaM creat c
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false
is: HMDB00064
type: Species
constant: false
initial amount: NaN
is: CHEBI:16919
boundary condition: false
name: creatine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_9cdd8ee2_3e91_48f8_9d3e_ffd84b7f1e74
initial concentration: NaN
boundary condition: true
name: KDSR
has only substance units: false
initial amount: NaN
is: Q06136
is encoded by: hsa:2531
type: Species
is: SBO:0000252
constant: false

metaR r0617
fast: false
product: MODEL1310110046#
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
kinetic law: MODEL1310110046#
type: Reaction

metaM cspg b l
boundary condition: false
is: CHEBI:36005
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: HMDB02183
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaM taur x
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:15891
name: taurine
is: SBO:0000247
constant: false
is: HMDB00251
initial concentration: 1.0
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245

metaR HSD17B3r
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3293.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12429500 NOTES:Human kidney cell line used and Km/Vmax quantified
kinetic law: MODEL1310110046#
name: testicular 17-beta-hydroxysteroid dehydrogenase
is described by: ECO:0000134
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.64
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#

metaR r1012
is described by: ECO:0000000
reversible: false
product: MODEL1310110046#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_6fa1edaa_1f4e_4c33_bfd6_bf2bf4db1eaf
is: SBO:0000252
initial amount: NaN
type: Species
is: P51857
has only substance units: false
name: AKR1D1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6718

http://identifiers.org/biomodels.db/MODEL1310110046#_18001ef2_e077_4657_864b_9d763e3e259e
is: SBO:0000252
type: Species
is: Q546E0
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: FUT8
is encoded by: hsa:2530
initial amount: NaN

metaM galside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
initial amount: NaN
has only substance units: false
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial concentration: 1.0
is: CHEBI:12947
is: SBO:0000247
constant: false

metaR PHEtec
reactant: MODEL1310110046#
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110046#
reversible: true
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110046#

metaR CBASPte
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185
reversible: true
product: MODEL1310110046#
name: Transport of N-carbamoyl-L-aspartate
reactant: MODEL1310110046#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110046#_f5678ae6_b895_4d2f_b228_405eb1771b3e
boundary condition: true
is encoded by: hsa:221823
type: Species
is: P21108
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PRPS1L1
is: SBO:0000252
constant: false

metaR DLNLCGCPT2
reversible: false
kinetic law: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reactant: MODEL1310110046#
fast: false
name: carnitine transferase
product: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110046#

metaR DCSPTN1CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110046#
name: carnitine transferase

metaM ksi deg15 l
name: keratan sulfate I, degradation product 15
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:12936
constant: false
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
initial amount: NaN
has only substance units: false

metaM fpram c
initial concentration: 1.0
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: HMDB06211
has only substance units: false
type: Species
is: C04640
is: SBO:0000247
boundary condition: false
is: CHEBI:58478
constant: false
initial amount: NaN

metaR RE2799C
reactant: MODEL1310110046#
type: Reaction
reversible: true
name: RE2799
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110046#

metaM udpg e
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species
constant: false
is: HMDB00286
initial concentration: 1.0
is: CHEBI:58367
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_10869947_0615_41a9_a155_3d0d1d90c6b7
is encoded by: hsa:5167
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P22413
name: ENPP1

http://identifiers.org/biomodels.db/MODEL1310110046#_21bdee4a_bf48_4741_87af_8b02aeb43d43
is encoded by: hsa:641371
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: E9KL42
initial concentration: NaN
constant: false
name: ACOT1

metaR FAOXC150m
product: MODEL1310110046#
fast: false
name: Beta oxidation of long chain fatty acid (odd chain)
reactant: MODEL1310110046#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110046#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
kinetic law: MODEL1310110046#

metaR FADH2tx
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110046#
name: FADH2 transporter, peroxisomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_25a6d871_f51f_4749_9ed8_f4a462090d08
is: P17568
is encoded by: hsa:4713
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: NDUFB7
initial concentration: NaN

metaR r1013
fast: false
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reversible: false
reactant: MODEL1310110046#
name: Transport reaction

metaR FACOAL170
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000000

metaR GLCNACASE5ly
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
fast: false

metaR DCSPTN1CPT1
reactant: MODEL1310110046#
fast: false
reversible: false
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110046#
type: Reaction

metaR r1552
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#

metaM CE5119 m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: trans-3-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
type: Species
constant: false
is: CHEBI:57923
initial amount: NaN

metaR DLNLCGCPT1
kinetic law: MODEL1310110046#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
reactant: MODEL1310110046#
name: carnitine O-palmitoyltransferase
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_da67752a_63c2_4a5a_8379_a35f140474ea
is: SBO:0000252
type: Species
is encoded by: hsa:57127
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: RHBG
is: Q9H310
constant: false
has only substance units: false

metaM lnlccoa c
constant: false
type: Species
is: HMDB01064
initial concentration: 1.0
is: SBO:0000247
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_dbcebd60_7a70_4b44_945f_47917d24f8e9
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:R14373
name: _R14373_1_x
boundary condition: true
initial amount: NaN
type: Species

metaM dtdp m
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: dTDP
is: C00363
type: Species
is: HMDB01274
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58369
constant: false
has only substance units: false

metaM creat e
is: HMDB00064
initial concentration: 1.0
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:16919
is: SBO:0000247
boundary condition: false
name: creatine

metaR DMATTx
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
name: dimethylallyltranstransferase
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.1
is: SBO:0000176
product: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
type: Reaction

metaR r0249
fast: false
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
kinetic law: MODEL1310110046#
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.7.12

http://identifiers.org/biomodels.db/MODEL1310110046#_890beaf8_0b3e_4ab9_906b_b1239aef6710
has only substance units: false
constant: false
is encoded by: hsa:478
is: SBO:0000252
is: B7Z2T0
initial concentration: NaN
type: Species
name: ATP1A3
boundary condition: true
initial amount: NaN

metaR B3GALT5g
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: Beta-1,3-galactosyltransferase 5

metaR r1014
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
is: SBO:0000185
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110046#

metaM prgnlone m
is: SBO:0000247
type: Species
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
is: HMDB00253
constant: false
name: pregnenolone
is: CHEBI:16581
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM cholate e
name: Cholate
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaR ASNtN1
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185
fast: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
name: Asparagine transport (Na, H coupled)
type: Reaction
is described by: ECO:0000269

metaR r1553
type: Reaction
reversible: true
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_68908547_6054_4b1b_b9d0_b6b4ca90a4ed
is: Q96P26
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:93034
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: NT5C1B
has only substance units: false

metaR P45011A1m
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.15.6
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
product: MODEL1310110046#
type: Reaction

metaM dtdp n
is: HMDB01274
is: SBO:0000247
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
is: CHEBI:58369
type: Species

metaM thexddcoa m
initial concentration: 1.0
boundary condition: false
name: trans7,10-hexadecadienoylcoa
is: HMDB02288
is: SBO:0000247
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_9140be85_3c65_4e09_9d25_68c26ee31e1f
is encoded by: hsa:93034
is: Q96P26
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NT5C1B
type: Species

metaR P4508B11r
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: sterol 12-alpha-hydroxylase
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
product: MODEL1310110046#
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.95

metaM galside hs e
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_8d93f75a_b0c3_4da8_9d06_39080fe013d7
type: Species
initial amount: NaN
has only substance units: false
is: Q53HE2
name: TPI1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7167
constant: false

metaM trdrd c
type: Species
is: C00342
name: Reduced thioredoxin
constant: false
is: CHEBI:15967
has only substance units: false
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_a510c451_14c4_4b9f_8abe_070b85d61168
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: B3KUN3
name: AHCY
is encoded by: hsa:191
initial concentration: NaN

metaM lnlccrn c
type: Species
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false
is: SBO:0000247
name: Linoleyl carnitine
is: HMDB06469
constant: false
boundary condition: false
initial concentration: 1.0

metaR METt4
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
name: L-methionine transport in via sodium symport
is described by: ECO:0000269
fast: false

metaM hco3 c
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
initial concentration: 1.0
name: Bicarbonate
has only substance units: false
is: SBO:0000247
is: HMDB00595
is: CHEBI:17544
constant: false
is: C00288
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_68b8f7bc_3702_4e3c_850f_5edf6c553547
is: Q96QE2
name: SLC2A13
constant: false
is encoded by: hsa:114134
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_430f35f7_72d3_46fa_b9ee_4e07f8848437
has only substance units: false
constant: false
name: SLC25A26
boundary condition: true
initial concentration: NaN
is encoded by: hsa:115286
is: SBO:0000252
is: F8WAB8
type: Species
initial amount: NaN

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaR SERGLNNaEx
reversible: false
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

metaM ala B m
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
initial amount: NaN
is: HMDB00056
constant: false
has only substance units: false
type: Species
name: beta-alanine
boundary condition: false
is: CHEBI:16958

metaR NICRNS
type: Reaction
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
reversible: false
product: MODEL1310110046#
name: NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
is described by: ECO:0000000

metaM 4h2oglt m
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB02070
name: 4-hydroxy-2-oxoglutarate(2-)
constant: false
initial amount: NaN
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
boundary condition: false
is: CHEBI:17742
has only substance units: false

metaR NACHEX20ly
product: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110046#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176

metaR CSPG Etly
is described by: ECO:0000000
name: chondroitin sulfate E transport, extracellular to lysosome
type: Reaction
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110046#

metaM cholate c
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN
name: Cholate
initial concentration: 1.0
boundary condition: false
is: CHEBI:29747
is: SBO:0000247
has only substance units: false
is: HMDB00619
type: Species
constant: false

metaM n2m2nmn l
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00742
is: SBO:0000247
notes: FORMULA: C50H84N4O36 CHARGE: 0
boundary condition: false
constant: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: CHEBI:17588

metaR r0614
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:

metaM galside hs g
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: D-galactosyl-N-acylsphingosine
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_c94dcf91_ce04_40f1_8b40_8c6064745a9f
name: GGT2
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:728441
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_1bf1800d_5621_43d3_afdc_94d2d2ba4946
constant: false
initial concentration: NaN
name: SLCO3A1
initial amount: NaN
type: Species
is: Q9UIG8
is encoded by: hsa:28232
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM acgam1p c
is: CHEBI:7125
name: N-Acetyl-D-glucosamine 1-phosphate
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: HMDB01367

metaR r1559
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110046#

metaR CLPNDt
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM hco3 e
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
boundary condition: false
is: HMDB00595
initial concentration: 1.0
name: Bicarbonate
constant: false
has only substance units: false
is: CHEBI:17544
is: C00288
type: Species
initial amount: NaN

metaR r0245
product: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72

http://identifiers.org/biomodels.db/MODEL1310110046#_5aec35ad_7388_437d_bf18_3129a79ad82d
name: SKIV2L2
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:23517
constant: false
is: Q3MHC9
type: Species
initial amount: NaN
is: SBO:0000252

metaR PTPATe
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
name: PTPATe
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#

metaM xyl D c
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
boundary condition: false
has only substance units: false
name: aldehydo-D-xylose
initial concentration: 1.0
is: CHEBI:15936

metaR KSII CORE4t
kinetic law: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110046#
name: keratan sulfate II (core4) transport, golgi to extracellular
type: Reaction
reactant: MODEL1310110046#
reversible: false
is described by: ECO:0000000

metaR SUCD1m
reactant: MODEL1310110046#
fast: false
type: Reaction
reversible: true
product: MODEL1310110046#
name: succinate dehydrogenase
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.5.1

metaM hmbil c
initial amount: NaN
is: C01024
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
initial concentration: 1.0
is: HMDB01137
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57845
type: Species
name: Hydroxymethylbilane
has only substance units: false

metaM ach e
initial amount: NaN
is: HMDB00895
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: acetylcholine
is: CHEBI:15355

http://identifiers.org/biomodels.db/MODEL1310110046#_39f8660a_e058_4c4e_b3c0_a0ddd6af62c6
constant: false
is encoded by: hsa:BF195998
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _BF195998_1_x
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_b132f1c5_ca5b_4dcb_9734_1eea6af5738d
is encoded by: hsa:2591
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GALNT3
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q14435

metaR r0615
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.168
reversible: true
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaM dolmanp U c
boundary condition: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:15809
name: Dolichyl phosphate D-mannose, human uterine homolog

metaR FAOXC11C9m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_8559c233_b824_4616_8bff_8be0e4c235b2
is encoded by: hsa:146712
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: Q67FW5
initial concentration: NaN
name: B3GNTL1

http://identifiers.org/biomodels.db/MODEL1310110046#_8901c946_7fb1_48d7_8e5d_3fc7d577032d
is encoded by: hsa:39
name: ACAT2
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: Q9BWD1
has only substance units: false

metaM cdpdag hs c
is: SBO:0000247
name: CDP-diacylglycerol(2-)
type: Species
constant: false
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r0246
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b873872a_e2c4_40b9_a771_c4b3af939a8c
type: Species
name: SLC7A6
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:9057
is: SBO:0000252
is: Q92536

metaR r1018
kinetic law: MODEL1310110046#
name: Transport reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
is described by: ECO:0000000

metaM nadp x
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58349
is: HMDB00217
type: Species
is: SBO:0000247
constant: false

metaR r0616
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
is: SBO:0000176
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true

metaR r1557
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110046#_b37ec954_501b_4419_80db_2d05cb047e21
has only substance units: false
is: SBO:0000297
boundary condition: true
has part: P48201
is encoded by: hsa:518
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2

http://identifiers.org/biomodels.db/MODEL1310110046#_423df7c6_8a2b_401f_85ac_c0afcbede853
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:T83654
name: _T83654_1_m
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_61b09399_e05c_489b_89dd_3efc9318a030
has only substance units: false
name: CAD
type: Species
is: P27708
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:790
initial amount: NaN
initial concentration: NaN

metaR BUTt2m
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
name: Butyrate mitochondrial transport via proton symport, reversible
reversible: true
fast: false
modifier: MODEL1310110046#
is: SBO:0000185

metaM ksi deg33 l
is: HMDB00143
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 33
type: Species
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:12936

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reversible: true
type: Reaction
is described by: ECO:0000254
product: MODEL1310110046#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176

metaR LINOFATPtc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaM chol r
boundary condition: false
has only substance units: false
is: HMDB00097
initial concentration: 1.0
name: choline
constant: false
is: CHEBI:15354
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species

metaM T4hcinnm m
is: CHEBI:12876
initial concentration: 1.0
name: trans-4-coumarate
boundary condition: false
has only substance units: false
type: Species
is: HMDB02035
is: SBO:0000247
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
constant: false
initial amount: NaN

metaR r0791
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
type: Reaction
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#

metaM pppg9 m
is: SBO:0000247
is: HMDB01097
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
name: Protoporphyrinogen IX
boundary condition: false
is: CHEBI:57307
is: C01079

metaR r0242
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR r0196
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
kinetic law: MODEL1310110046#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
type: Reaction

metaR PIACGT
is version of: http://identifiers.org/ec-code/2.4.1.198
reversible: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
name: phosphatidylinositol N-acetylglucosaminyltransferase
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.83
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_7452c14d_d252_4d90_9472_1a406bb41194
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: NDUFA4
is: O00483
is encoded by: hsa:4697

metaR RE3242R
fast: false
name: RE3242
reversible: true
type: Reaction
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176

metaR ASCBt
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
product: MODEL1310110046#
name: L-ascorbate transport via facilitated diffusion
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_00e29258_5d2f_4fa3_9934_3e23dd806a6a
is: G3XAD7
constant: false
is encoded by: hsa:1583
name: CYP11A1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r0942
is: SBO:0000185
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is described by: ECO:0000000
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4

http://identifiers.org/biomodels.db/MODEL1310110046#_28795869_8e4b_46a8_96c0_f38a0ebea99f
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:205
type: Species
name: AK4
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR RE0383C
reactant: MODEL1310110046#
reversible: true
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
name: RE0383
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110046#

metaM dlnlcgcoa r
is: C03595
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_690f0bba_6f27_4bc4_a1e4_ff90801342e3
initial concentration: NaN
is: O75106
name: AOC2
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:314
constant: false
is: SBO:0000252

metaM ctdecdcoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: HMDB00672
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: cis2trans4decadienoylcoa
type: Species
initial concentration: 1.0
is: C08260
initial amount: NaN

metaM hdcea r
is: SBO:0000247
type: Species
is: HMDB03229
name: palmitoleate
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b3e41801_01e7_4305_a9d6_489caeb9940a
type: Species
initial concentration: NaN
name: CA7
constant: false
is: Q86YU0
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:766

http://identifiers.org/biomodels.db/MODEL1310110046#_c2be39ef_e577_42d2_b9bd_0ec6139d5985
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: _U37519_1_m
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:U37519

metaR r1609
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#

metaM ksi deg20 l
name: keratan sulfate I, degradation product 20
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB00143
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: CHEBI:12936

metaR HEX7
name: hexokinase (D-fructose:ATP)
modifier: MODEL1310110046#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110046#

metaR RE1807C
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
fast: false
is: SBO:0000176
product: MODEL1310110046#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_941d9c0f_cf97_4763_b847_c124a8fd1c77
constant: false
is: SBO:0000252
is encoded by: hsa:5230
initial concentration: NaN
name: PGK1
boundary condition: true
is: P00558
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_3810b253_fba5_4b5c_80b6_b7a0f89892b6
initial concentration: NaN
is: G0W2N5
is: SBO:0000252
boundary condition: true
name: SLC14A1
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:6563
has only substance units: false

metaR FAOXC9C7m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaR S4TASE3ly
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110046#
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
fast: false

metaR r0941
type: Reaction
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false

metaM 5oxpro c
is: HMDB00267
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
constant: false
name: 5-oxoprolinate
is: CHEBI:57606
initial concentration: 1.0
boundary condition: false

metaR FAOXC181C181OHm
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaM phaccoa c
is: SBO:0000247
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
type: Species
initial concentration: 1.0
is: HMDB06503
name: phenylacetyl-CoA(4-)
has only substance units: false
is: CHEBI:57390
initial amount: NaN
boundary condition: false
constant: false

metaR HPCLx
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
fast: false
product: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (26062.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10468558 NOTES:pristanal is the fatty aldehyde analog of pristanic acid Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. NJ
reversible: false
name: 2-hydroxyphytanoyl-CoA lyase
is described by: ECO:0000269

metaR C4STMO2Pr
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
modifier: MODEL1310110046#
name: C-4 methyl sterol oxidase
kinetic law: MODEL1310110046#
reversible: false
product: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.170

http://identifiers.org/biomodels.db/MODEL1310110046#_81193718_15d8_4f0d_900e_a97fa48b2739
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: UGP2
is: Q16851
is encoded by: hsa:7360

metaM c8dc x
initial concentration: 1.0
is: HMDB06351
boundary condition: false
name: suberyl carnitine
has only substance units: false
constant: false
notes: FORMULA: C15H26NO6 CHARGE: -1
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_c12e9be5_8cd4_430e_8fe3_c1b2492c435f
is encoded by: hsa:18
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: ABAT
constant: false
has only substance units: false

metaM prgnlone c
is: SBO:0000247
name: pregnenolone
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
type: Species
boundary condition: false
is: CHEBI:16581
is: HMDB00253
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR DOPASFt
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: false
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
fast: false
name: Dopamine 3-0-sulfate transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110046#_05c14046_d6f7_4030_8c32_c249af261a75
boundary condition: true
has only substance units: false
name: SLC8A3
initial concentration: NaN
is: Q96QG2
initial amount: NaN
is encoded by: hsa:6547
type: Species
is: SBO:0000252
constant: false

metaR TREHe
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
type: Reaction
product: MODEL1310110046#
reversible: false
name: alpha,alpha-trehalase
is version of: http://identifiers.org/ec-code/3.2.1.28
fast: false
is: SBO:0000176
modifier: MODEL1310110046#

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: CHEBI:18401
initial concentration: 1.0
is: HMDB00209
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: phenylacetate
initial amount: NaN

metaR AG13T6g
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_ac7e6bf0_c8dd_4523_a32c_d1af144c1e09
has only substance units: false
initial amount: NaN
is encoded by: hsa:6716
name: SRD5A2
is: P31213
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR SERALANaEx
is: SBO:0000185
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
product: MODEL1310110046#
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_ffeba752_cc31_4f9e_85f0_f49f9819bf76
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI469183
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: _AI469183_1_x
type: Species

metaM xol27oh r
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
initial concentration: 1.0
name: 26-hydroxycholesterol
boundary condition: false
is: CHEBI:17703
type: Species

metaR r0940
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
name: Free diffusion
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
reversible: true
is described by: ECO:0000000

metaR r0792
product: MODEL1310110046#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
reactant: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM 2maacoa m
boundary condition: false
type: Species
is: SBO:0000247
constant: false
name: 2-methylacetoacetyl-CoA(4-)
has only substance units: false
is: CHEBI:57335
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_78b9d86e_4c61_4048_acb9_40583fc6de94
boundary condition: true
name: SLC16A1
is: SBO:0000252
initial amount: NaN
is: B4DKS0
type: Species
is encoded by: hsa:6566
has only substance units: false
initial concentration: NaN
constant: false

metaM dtdp e
type: Species
is: HMDB01274
boundary condition: false
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false

metaR CYSSERNaEx
reactant: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
is: SBO:0000185

metaR r1607
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#

metaM ach n
type: Species
has only substance units: false
constant: false
is: HMDB00895
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
name: acetylcholine
is: SBO:0000247

metaM betald c
is: CHEBI:15710
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
name: betaine aldehyde
type: Species
is: HMDB01252
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR SERPT
type: Reaction
name: serine C-palmitoyltransferase
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.50

metaR CDIPTr
is described by: ECO:0000000
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: phosphatidylinositol synthase (Homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.8.11
reversible: true
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
fast: false
product: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction

metaM ksii core2 deg5 l
is: CHEBI:12936
constant: false
initial concentration: 1.0
is: HMDB00143
has only substance units: false
initial amount: NaN
notes: FORMULA: C50H82N4O38SX CHARGE: -1
name: keratan sulfate II (core 2-linked), degradation product 5
type: Species
is: SBO:0000247
boundary condition: false

metaM hs deg12 l
boundary condition: false
constant: false
is: SBO:0000247
name: heparan sulfate, degradation product 12
has only substance units: false
initial concentration: 1.0
is: CHEBI:17180
type: Species
initial amount: NaN
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
is: HMDB01352

metaR r0620
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110046#
name: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
is: SBO:0000176
product: MODEL1310110046#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_a90a4d24_8ef2_43b9_b4b4_f2c6730083dd
is: Q9BYC5
constant: false
initial amount: NaN
name: FUT8
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2530
boundary condition: true
type: Species
is: SBO:0000252

metaM man6p c
type: Species
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
boundary condition: false
is: SBO:0000247
has only substance units: false
name: D-Mannose 6-phosphate
initial amount: NaN
constant: false
is: HMDB01078
is: CHEBI:17369

metaR r0795
kinetic law: MODEL1310110046#
reversible: false
product: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
fast: false
name: Spontaneous reaction
type: Reaction
modifier: MODEL1310110046#

metaR FACOAL2252
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
product: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
reversible: true
is described by: ECO:0000269
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110046#_01df5e0c_d0a3_4fbf_a2ce_417b1e2c7d06
initial amount: NaN
name: PIGC
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5279
constant: false
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_01163398_9c00_4fb7_b347_7ec5296fe301
is: O14975
type: Species
initial concentration: NaN
name: SLC27A2
constant: false
has only substance units: false
is encoded by: hsa:11001
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r0946
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false

metaR FAOXC2442246x
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR RE3381E
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110046#
fast: false
name: RE3381
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110046#

metaM 4hpro LT e
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
boundary condition: false
is: SBO:0000247
is: HMDB00725
initial concentration: 1.0
has only substance units: false
name: trans-4-hydroxy-L-proline

metaM stcoa m
is: HMDB01114
is: CHEBI:57394
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Stearoyl-CoA (n-C18:0CoA)
has only substance units: false
constant: false
is: C00412
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_7b055208_56cf_4063_86cc_78bb1625c25f
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: GGT5
has only substance units: false
type: Species
is: P36269
is encoded by: hsa:2687

metaR r1608
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 5forthf c
is: CHEBI:57456
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: C00664
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: 5-Formiminotetrahydrofolate
is: HMDB01534
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5390c75f_7cf1_48e2_8264_8205aa461544
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:126328
is: C9JT23
name: NDUFA11

metaR SERATB0tc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Serine into the intestinal cells by ATB0 transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_9c123776_8e7b_4d58_9256_f2bd008358e4
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: ATP5J
is encoded by: hsa:522
has only substance units: false

metaR LEUKTRA4t
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
kinetic law: MODEL1310110046#
name: leukotriene A4 transport
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true

metaR CREATtmdiffir
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:14977199,PMID:3896131 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: Creatine transport to/from mitochondria via diffusion
is: SBO:0000185
fast: false
reactant: MODEL1310110046#

metaR DRBK
name: Deoxyribokinase
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.15
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_93d1b36b_acf8_47c7_8f8d_c837417f46a2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AI640625
constant: false
initial amount: NaN
name: _AI640625_1_c
has only substance units: false

metaM acald e
is: SBO:0000247
boundary condition: false
is: CHEBI:15343
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00990
has only substance units: false
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde

metaM dlnlcg e
constant: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
name: dihomo-gamma-linolenic acid (n-6)
is: SBO:0000247
initial concentration: 1.0
is: HMDB02925
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:53486

metaR B MANNASEly
is: SBO:0000176
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: beta-mannosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.25
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: false

metaR r0193
is: SBO:0000176
type: Reaction
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
kinetic law: MODEL1310110046#
reversible: true
product: MODEL1310110046#
is described by: ECO:0000000
fast: false

metaR r0797
reversible: true
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
type: Reaction
kinetic law: MODEL1310110046#
name: glycine N-choloyltransferase EC:2.3.1.65
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM dlnlcgcoa m
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
has only substance units: false
is: CHEBI:27979
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaM dcmp c
initial concentration: 1.0
boundary condition: false
is: C00239
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
type: Species
is: SBO:0000247
is: HMDB01202
has only substance units: false
constant: false
name: dCMP
initial amount: NaN

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR r1605
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NADtx
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: transport of NAD into peroxisome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110046#
is: SBO:0000185

metaM cdpdag hs m
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: CDP-diacylglycerol(2-)
initial amount: NaN
is: CHEBI:58332
initial concentration: 1.0

metaM xol27oh m
is: HMDB02103
has only substance units: false
is: CHEBI:17703
initial amount: NaN
initial concentration: 1.0
name: 26-hydroxycholesterol
is: SBO:0000247
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
boundary condition: false
constant: false

metaR FAOXC227C226m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_85dbdc4e_8236_46b4_a439_a5d37ed94ea9
is: Q8TBF5
type: Species
has only substance units: false
is: SBO:0000252
name: PIGX
is encoded by: hsa:54965
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaR FACOAL191
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110046#

metaR r1551
is: SBO:0000185
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_db97e016_a42d_43d0_9e43_1955c3d5bb32
initial amount: NaN
is encoded by: hsa:10164
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: CHST4
constant: false
initial concentration: NaN
is: Q8NCG5

metaM grdp x
name: geranyl diphosphate(3-)
initial concentration: 1.0
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: HMDB01285
is: CHEBI:58057
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial amount: NaN

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaR r0944
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
name: Active transport

metaM malcoa c
is: SBO:0000247
name: Malonyl-CoA
is: HMDB01175
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C00083
is: CHEBI:57384
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaR r1606
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM 4hpro LT c
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
type: Species
is: CHEBI:18095
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: trans-4-hydroxy-L-proline
is: SBO:0000247
initial concentration: 1.0
is: HMDB00725

metaR CYTK4n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110046#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
name: cytidylate kinase (dCMP,GTP),nuclear
type: Reaction
is: SBO:0000176

metaR GLCAASE7ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
name: beta-glucuronidase, lysosomal
reversible: false
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_927412e5_1468_4481_b888_872af9b4aee4
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55907
is: Q8NFW8
boundary condition: true
initial concentration: NaN
name: CMAS
has only substance units: false
constant: false
type: Species

metaR RE3567C
is described by: ECO:0000000
kinetic law: MODEL1310110046#
name: RE3567
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
reversible: true

metaR M16NTg
kinetic law: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
fast: false
reversible: false
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
product: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.143

metaR MMTSADm
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
fast: false
is: SBO:0000176
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
reversible: false

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_49457f30_6240_480b_a791_fbf2a5b61a59
name: HSD11B2
constant: false
type: Species
initial concentration: NaN
is: P80365
is encoded by: hsa:3291
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR GLYCLTDy
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES:JLR
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110046#
type: Reaction
name: Glycolate dehydrogenase (NADP)
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.79
kinetic law: MODEL1310110046#

metaR FAOXC121x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR r0796
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
type: Reaction
modifier: MODEL1310110046#

metaM ac c
constant: false
initial amount: NaN
name: acetate
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: CHEBI:30089
is: HMDB00042
initial concentration: 1.0

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction

metaR RE3556C
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
name: RE3556
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
reversible: true
type: Reaction

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_70181e57_067d_4eab_959e_51565aaf6183
initial concentration: NaN
initial amount: NaN
name: OGDH
boundary condition: true
constant: false
type: Species
has only substance units: false
is: Q02218
is encoded by: hsa:4967
is: SBO:0000252

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_a78bed35_9d95_4491_9f26_7da54eaeea17
is encoded by: hsa:4710
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: NDUFB4
type: Species
constant: false
is: O95168
initial amount: NaN
has only substance units: false

metaM 7dhchsterol c
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial concentration: 1.0
is: HMDB00032
type: Species
is: SBO:0000247
name: cholesta-5,7-dien-3beta-ol

metaR 3MOBte
type: Reaction
reactant: MODEL1310110046#
fast: false
product: MODEL1310110046#
name: Transport of 3-methyl-2-oxobutanoate
reversible: true
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185

metaR CHSTEROLtrc
reactant: MODEL1310110046#
is: SBO:0000185
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
name: transport of cholesterol into the cytosol
type: Reaction
product: MODEL1310110046#
fast: false

metaR ACHEe
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
fast: false
name: Acetylcholinesterase
reversible: false
is described by: ECO:0000269
product: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.1.7
kinetic law: MODEL1310110046#

metaM cl c
notes: FORMULA: Cl CHARGE: -1
constant: false
name: Chloride
initial amount: NaN
is: HMDB00492
type: Species
is: SBO:0000247
is: C00115
boundary condition: false
has only substance units: false
is: CHEBI:3966
initial concentration: 1.0

metaR TRDR
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110046#
name: thioredoxin reductase (NADPH)
reversible: false
is described by: ECO:0000269

metaM pppg9 c
is: SBO:0000247
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
initial concentration: 1.0
boundary condition: false
is: CHEBI:57307
constant: false
name: Protoporphyrinogen IX
is: C01079
has only substance units: false
is: HMDB01097
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_e2f3da50_942e_4bfc_83ab_e105165903a3
has only substance units: false
name: IK
is: Q13123
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:3550

metaR RE1903R
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
type: Reaction
product: MODEL1310110046#
name: RE1903
is: SBO:0000176
reactant: MODEL1310110046#
fast: false
reversible: true
kinetic law: MODEL1310110046#

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR NAt3 1
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110046#
name: sodium proton antiporter (H:NA is 1:1)
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
reversible: true

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR RE0577C
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110046#
name: RE0577
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_37f2077b_d17c_466a_ace0_5bfaf6e29dd7
is encoded by: hsa:5322
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: P39877
name: PLA2G5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_0158a93d_d283_403d_8b0e_8bc18104f79e
constant: false
initial concentration: NaN
name: PANK1
is encoded by: hsa:53354
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

metaR CORE4GTg
reversible: false
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.102
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR r1109
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reversible: true
product: MODEL1310110046#
type: Reaction

metaR TDPm
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
name: thiamin pyrophosphatase, mitochondrial
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT

http://identifiers.org/biomodels.db/MODEL1310110046#_e6de055b_4637_44f6_b29d_150b76140a1b
type: Species
name: PIK3C2A
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: O00443
has only substance units: false
boundary condition: true
is encoded by: hsa:5286

metaR r0688
reactant: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_44d8920f_42dc_4971_9cce_42e8454b4d1a
has only substance units: false
initial concentration: NaN
is encoded by: hsa:53354
boundary condition: true
constant: false
is: Q8TE04
is: SBO:0000252
name: PANK1
type: Species
initial amount: NaN

metaM chol m
constant: false
boundary condition: false
has only substance units: false
is: HMDB00097
initial concentration: 1.0
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:15354

metaM cl e
is: CHEBI:3966
constant: false
is: HMDB00492
is: SBO:0000247
name: Chloride
is: C00115
type: Species
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR CYTK10n
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
name: cytidylate kinase (CMP,dGTP),nuclear
reversible: true

metaM dlnlcg c
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
initial concentration: 1.0
name: dihomo-gamma-linolenic acid (n-6)
initial amount: NaN
type: Species
is: CHEBI:53486
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB02925

metaM stcoa c
is: CHEBI:57394
is: HMDB01114
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Stearoyl-CoA (n-C18:0CoA)
constant: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
has only substance units: false
type: Species
is: C00412
boundary condition: false

metaM n2m2masn g
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
notes: FORMULA: C50H83N4O35X CHARGE: 0
is: C11530

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_9257c8d4_882a_4a70_a9fd_4e2d73fe0743
is encoded by: hsa:271
type: Species
constant: false
name: AMPD2
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B2RB47
initial concentration: NaN
initial amount: NaN

metaM hexdectecoa x
type: Species
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN
boundary condition: false
is: HMDB02288
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM acald c
is: SBO:0000247
is: CHEBI:15343
name: acetaldehyde
is: HMDB00990
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
constant: false

metaR FATP6t
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
modifier: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
name: fatty acid electroneutral transport
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
product: MODEL1310110046#

metaR CYTDK2m
reversible: false
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000176
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_1eb8c163_de74_4ca1_a3d1_b4d1c4710c43
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1346
constant: false
type: Species
initial amount: NaN
is: P24310
name: COX7A1
boundary condition: true

metaM 4hpro LT m
has only substance units: false
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: CHEBI:18095
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00725
boundary condition: false
name: trans-4-hydroxy-L-proline

http://identifiers.org/biomodels.db/MODEL1310110046#_30dd2c8a_5010_4ecd_9d01_9ae8d07bdbb8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: E7ET30
is encoded by: hsa:50808
type: Species
initial amount: NaN
constant: false
name: AK3

metaR HEX4
product: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
modifier: MODEL1310110046#
name: hexokinase (D-mannose:ATP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
kinetic law: MODEL1310110046#
is described by: ECO:0000304

metaM chol n
has only substance units: false
is: HMDB00097
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
initial concentration: 1.0
name: choline
constant: false
is: CHEBI:15354

metaM 5oxpro e
is: HMDB00267
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57606
name: 5-oxoprolinate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_0f8876fc_793e_4019_8c04_2ca778b12d63
initial amount: NaN
is encoded by: hsa:8706
is: O75752
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: B3GALNT1

metaM 5pmev c
is: HMDB01343
constant: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: (R)-5-phosphonatomevalonate(3-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_4682a9b2_fd15_4176_bab8_27b3c2fa98cc
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000297
initial concentration: NaN
type: Species
has only substance units: false

metaR S6T1g
modifier: MODEL1310110046#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#

metaR AMANK
is version of: http://identifiers.org/ec-code/5.1.3.14
type: Reaction
name: N-acetyl-D-mannosamine kinase
fast: false
modifier: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
is version of: http://identifiers.org/ec-code/2.7.1.59
product: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269

metaR LTC4CP
fast: false
name: Leukotriene C4 carboxypeptidase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_1fdf9021_3f63_4ee2_9d74_d1f88d158cd3
is: F5H6D0
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7841
has only substance units: false
name: MOGS
is: SBO:0000252
constant: false

metaM xol7ah2 c
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:28047
is: HMDB06893
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha-diol
constant: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452

metaR FAOXC1811601m
modifier: MODEL1310110046#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
name: Beta oxidation fatty acid

metaM dtdp c
has only substance units: false
constant: false
is: HMDB01274
type: Species
initial concentration: 1.0
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: SBO:0000247
name: dTDP
initial amount: NaN
is: CHEBI:58369

http://identifiers.org/biomodels.db/MODEL1310110046#_7d10da9d_3039_451c_9790_b66fdc69f866
constant: false
has only substance units: false
is: SBO:0000252
name: RPE
is encoded by: hsa:6120
is: Q53TV9
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR FAOXC200180m
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110046#

metaR RE1807M
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110046#
name: RE1807
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_8ae5d2c5_ed07_41bb_9b9c_665b496503dd
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ALDH3B1
boundary condition: true
initial concentration: NaN
constant: false
is: P43353
is encoded by: hsa:221
type: Species

metaM m3mpdol L c
constant: false
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
is: CHEBI:37632
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
is: SBO:0000247
initial amount: NaN
type: Species

metaM tymsf c
is: HMDB06409
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial amount: NaN
name: Tyramine O-sulfate

metaM hdcea e
boundary condition: false
initial concentration: 1.0
name: Hexadecenoate (n-C16:1)
is: SBO:0000247
initial amount: NaN
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
is: HMDB03229
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_67df7cfa_4be3_4069_a829_923016b63c18
is: P23368
initial concentration: NaN
is: SBO:0000252
name: ME2
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4200
type: Species
boundary condition: true

metaM docohepcoa m
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
type: Species
constant: false
is: SBO:0000247

metaR r1106
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
reactant: MODEL1310110046#

metaM mthgxl c
is: CHEBI:17158
initial concentration: 1.0
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
name: methylglyoxal
type: Species
is: HMDB01167
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r0514
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
modifier: MODEL1310110046#
product: MODEL1310110046#
fast: false
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
is: SBO:0000176

metaR RE1810M
product: MODEL1310110046#
name: RE1810
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_63faa4a6_e077_4d43_b23d_e41591ed34a0
constant: false
is encoded by: hsa:2182
initial concentration: NaN
is: SBO:0000252
is: Q5JWV8
name: ACSL4
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_257f5473_35f8_4e8e_a5a0_145ceb756f10
boundary condition: true
is encoded by: hsa:6898
is: P17735
initial amount: NaN
name: TAT
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_cf01a41f_1a66_4cb1_8fbb_e7c8583f1c39
name: SUOX
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6821
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: P51687

http://identifiers.org/biomodels.db/MODEL1310110046#_4808f75a_5157_4b9d_8145_6f5044308357
type: Species
is: E5KS60
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:8803
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SUCLA2

metaM ac e
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:30089
name: acetate
is: SBO:0000247
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_28649dd7_2f5b_4f8f_8635_9784d160e83f
is encoded by: hsa:22934
is: P49247
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: RPIA

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM amet c
initial concentration: 1.0
initial amount: NaN
is: HMDB01185
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
name: S-Adenosyl-L-methionine
is: C00019
is: CHEBI:15414
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_74e4c48b_e085_49d5_b502_9238b059ebed
boundary condition: true
is encoded by: hsa:AV727634
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _AV727634_1_c

http://identifiers.org/biomodels.db/MODEL1310110046#_9e96889d_34f1_4416_83d3_31c8d5bca052
is: P30613
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5313
name: PKLR
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_ba9b3195_f505_4720_bf76_124df61b6725
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ALDOA
constant: false
is encoded by: hsa:226
initial concentration: NaN
has only substance units: false
type: Species

metaR HEX1
is described by: ECO:0000134
product: MODEL1310110046#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110046#
type: Reaction
name: hexokinase (D-glucose:ATP)
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_a43b3f2b_85a8_4536_a2b0_dbf03c6afc18
initial amount: NaN
type: Species
constant: false
name: TXNRD2
is encoded by: hsa:10587
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM cala c
has only substance units: false
type: Species
is: CHEBI:11892
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial amount: NaN
constant: false
is: HMDB00026
boundary condition: false
name: N-carbamoyl-beta-alaninate

metaM tymsf e
has only substance units: false
is: HMDB06409
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
name: Tyramine O-sulfate

http://identifiers.org/biomodels.db/MODEL1310110046#_10182845_f3fb_48a9_88c2_e6ee4692e329
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9H3S5
type: Species
initial concentration: NaN
is encoded by: hsa:93183
initial amount: NaN
name: PIGM
constant: false

metaR r0683
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_c28e064f_b6e2_42f1_b8f0_58af3d8c7d9a
constant: false
is encoded by: hsa:10637
is: SBO:0000252
boundary condition: true
is: O75610
initial amount: NaN
initial concentration: NaN
name: LEFTY1
has only substance units: false
type: Species

metaR HGNTOR
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is: SBO:0000176
reactant: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.5
type: Reaction
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: false

metaR G14T17g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR r0512
reversible: true
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176

metaM btamp c
has only substance units: false
is: CHEBI:3110
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
type: Species
initial concentration: 1.0
name: Biotinyl-5'-AMP
constant: false
boundary condition: false
is: HMDB04220
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_bf0417e2_0807_4365_b49a_a1f4c7537025
is encoded by: hsa:8833
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: GMPS
is: SBO:0000252
type: Species
is: P49915

metaM C02470 c
is: HMDB00881
type: Species
is: C02470
initial amount: NaN
constant: false
name: Xanthurenic acid
has only substance units: false
is: http://identifiers.org/pubchem.compound/5485
initial concentration: 1.0
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f3d78014_dd0e_4b46_b597_d39a1e88e904
name: PKLR
boundary condition: true
type: Species
constant: false
is encoded by: hsa:5313
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR RETFAt
name: fatty acid retinol efflux
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false

metaM eicostet c
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB02177
name: eicosatetranoic acid
is: CHEBI:36033
type: Species
constant: false

metaM 5hoxindoa c
is: CHEBI:27823
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
type: Species
name: 5-Hydroxyindoleacetate
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00763
initial amount: NaN
boundary condition: false

metaR A4GALTg
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
kinetic law: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.228
name: Lactosylceramide 4-alpha-galactosyltransferase
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
fast: false

metaR r1435
reactant: MODEL1310110046#
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
name: Transport reaction
is described by: ECO:0000000
type: Reaction

metaR r1548
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false

metaM udpgal e
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: CHEBI:58439
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: UDP-D-galactose(2-)
constant: false
is: HMDB00302

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_28879980_6a72_4e33_97c6_8c8a07e5c2de
is: Q7Z7B1
name: PIGW
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:284098
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR FAOXC164x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaM chol c
is: C00114
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
has only substance units: false
name: Choline
is: CHEBI:15354
is: HMDB00097
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

metaR 3MOBt2im
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
type: Reaction
kinetic law: MODEL1310110046#
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
reversible: false
product: MODEL1310110046#
reactant: MODEL1310110046#

metaM eipencoa x
has only substance units: false
name: 2,5,8,11,14-eicosapentaenoylcoa
is: SBO:0000247
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790

metaR NDPK10
modifier: MODEL1310110046#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is described by: ECO:0000134
kinetic law: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
fast: false
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9f6d13b4_85e1_4cb0_b434_648c49f928bf
is: Q9HCR9
has only substance units: false
is: SBO:0000252
is encoded by: hsa:50940
type: Species
name: PDE11A
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_c0aefc70_0293_4177_b7a7_5e5a131b0e53
name: SUCLG1:SUCLA2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8803
has part: E5KS60
constant: false
type: Species
is: SBO:0000297
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5f284fe9_abbd_4f3c_8aad_02d5dbdb34f8
constant: false
name: GSTZ1
initial amount: NaN
is: O43708
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2954
type: Species

metaR r1756
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM nadp c
is: C00006
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349

http://identifiers.org/biomodels.db/MODEL1310110046#_97a4c174_1b3b_4dd2_aaa0_b23c344daaa2
constant: false
name: CHAT
initial amount: NaN
has only substance units: false
is: Q6LEN5
type: Species
boundary condition: true
is encoded by: hsa:1103
is: SBO:0000252
initial concentration: NaN

metaM ppi r
constant: false
has only substance units: false
is: C00013
boundary condition: false
type: Species
name: Diphosphate
is: HMDB00250
initial concentration: 1.0
is: CHEBI:33019
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247

metaR MANt1r
reactant: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
name: mannose transport (uniport)

metaR r1549
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110046#_0e2181df_2053_4224_b062_f2b1aca675b5
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:56901
initial amount: NaN
name: NDUFA4L2
is: SBO:0000252
constant: false
is: Q9NRX3

metaR FAOXC102C103x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR PROt2r
reversible: true
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000304
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
fast: false
name: L-proline reversible transport via proton symport

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110046#
type: Reaction
name: sialidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000

metaR A MANASEly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.24
name: alpha-mannosidase, lysosomal
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
reversible: false

metaM caro c
initial concentration: 1.0
name: beta-carotene
is: SBO:0000247
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
has only substance units: false
constant: false
is: HMDB00561
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:17579

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR FAOXC122m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR ATP2ter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110046#
fast: false
name: AMP/ATP transporter, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
reversible: true
product: MODEL1310110046#

metaM hdcea c
is: HMDB03229
is: CHEBI:32372
is: SBO:0000247
type: Species
name: Hexadecenoate (n-C16:1)
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

metaR PEAMNO
modifier: MODEL1310110046#
is described by: ECO:0000304
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
kinetic law: MODEL1310110046#
name: Phenethylamine oxidase
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
product: MODEL1310110046#

metaR r1755
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110046#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110046#
reversible: false
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_af2df13c_92cd_4278_b4ae_2a34127e862e
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: NPR2
is: SBO:0000252
is encoded by: hsa:4882
type: Species

metaR EHGLAT2m
reversible: false
is described by: ECO:0000304
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
modifier: MODEL1310110046#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9d83fccc_5e8f_4d64_a91d_fbed56d8e447
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10935
name: PRDX3
constant: false
initial amount: NaN
is: P30048
initial concentration: NaN

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_95324ade_1d09_452e_b1cd_9efae87b73cc
boundary condition: true
name: IDS
initial amount: NaN
has only substance units: false
is: B4DGD7
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3423

metaM Asn X Ser Thr r
is: SBO:0000247
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:28938
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: HMDB00051
type: Species
has only substance units: false
is: C01342

http://identifiers.org/biomodels.db/MODEL1310110046#_cb628479_1726_429e_8b8d_36b0c621cb3f
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: DGKZ
is: SBO:0000252
is: B7Z2M9
is encoded by: hsa:8525
has only substance units: false

metaM chol e
is: C00114
initial amount: NaN
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
name: Choline
has only substance units: false
is: HMDB00097
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_3e1430a4_4d17_4aad_87f5_15b8ef277edb
initial concentration: NaN
name: GNE
is encoded by: hsa:10020
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is: B7Z428
constant: false
has only substance units: false

metaM eicostet e
constant: false
is: CHEBI:36033
name: eicosatetranoic acid
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB02177

http://identifiers.org/biomodels.db/MODEL1310110046#_31eb5f85_8a2f_45dc_8494_30451bc1193e
name: GPX4
is encoded by: hsa:2879
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P36969
type: Species

metaR r0517
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37

metaR DOLDPP Ler
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.43
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
is: SBO:0000176
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
modifier: MODEL1310110046#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_f056dfd5_56c8_4b9d_ae45_77dc4ffbd26c
boundary condition: true
is: Q9NWU1
is: SBO:0000252
is encoded by: hsa:54995
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: OXSM
initial concentration: NaN

metaR NADHtru
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
name: NADH transporter, endoplasmic reticulum
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_e719a18b_d329_4ab1_86bf_d357ef191e15
name: FECH
is encoded by: hsa:2235
is: Q7KZA3
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaR CYOR u10m
type: Reaction
name: ubiquinol-6 cytochrome c reductase, Complex III
reversible: false
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is described by: ECO:0000134
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR AG13T13g
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110046#_5328210e_e4f1_456b_a075_18628eba17a4
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:PRO1933
name: _PRO1933_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_961c62d4_53bb_4cd0_ba7f_baa9247f5312
name: GALNT13
boundary condition: true
is encoded by: hsa:114805
initial amount: NaN
type: Species
initial concentration: NaN
is: Q8IUC8
has only substance units: false
constant: false
is: SBO:0000252

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
type: Reaction
name: Sulfate transport (lysosome)
reactant: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
fast: false
reversible: true

metaM udpgal c
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00302
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: CHEBI:58439
initial concentration: 1.0
name: UDP-D-galactose(2-)
constant: false

metaR 5HOXINDACTO2OX
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000304
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.3.1
modifier: MODEL1310110046#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
product: MODEL1310110046#
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110046#_b55be472_475f_4193_8124_3c29f3085eb9
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: PRODH
is encoded by: hsa:5625
is: O43272

http://identifiers.org/biomodels.db/MODEL1310110046#_9b9e0b37_e653_4fc3_95be_57ca16640b7b
initial concentration: NaN
has only substance units: false
is: Q6LEN6
boundary condition: true
type: Species
name: CHAT
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1103

metaM thbpt c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial amount: NaN
name: 5,6,7,8-tetrahydrobiopterin
is: HMDB00027
constant: false
is: CHEBI:15372
has only substance units: false
type: Species
boundary condition: false

metaR RE2541E
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
name: RE2541

metaM csn c
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: CHEBI:16040
is: HMDB00630
name: cytosine
constant: false
has only substance units: false

metaR RTOTAL2FATPc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR r0345
modifier: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_310f5897_fec6_4938_9edf_24267a4b2d6c
type: Species
is encoded by: hsa:9517
name: SPTLC1:SPTLC2
is encoded by: hsa:10558
constant: false
is: SBO:0000297
initial amount: NaN
boundary condition: true
has part: O15270
has only substance units: false
initial concentration: NaN
has part: O15269

http://identifiers.org/biomodels.db/MODEL1310110046#_399409ce_baef_4db3_99fb_1004b86d93cd
is encoded by: hsa:10400
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: PEMT
type: Species

metaR ITCOAL1m
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000304
modifier: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
name: Itaconate--CoA ligase (GDP-forming), mitochondrial

metaM m7masnB g
is: SBO:0000247
constant: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial concentration: 1.0
is: C05881
boundary condition: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
type: Species
initial amount: NaN
has only substance units: false

metaM caro e
constant: false
name: beta-carotene
type: Species
is: SBO:0000247
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00561
is: CHEBI:17579
boundary condition: false

metaR PSDm hs
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.1.1.65
modifier: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
fast: false
name: Phosphatidylserine decarboxylase
product: MODEL1310110046#

metaM f1p c
has only substance units: false
is: C01094
name: D-Fructose 1-phosphate
initial concentration: 1.0
is: CHEBI:18105
boundary condition: false
constant: false
is: HMDB01076
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
initial amount: NaN
type: Species
is: SBO:0000247

metaM uacgam c
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: CHEBI:57705
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
constant: false
is: HMDB00290
has only substance units: false
boundary condition: false

metaR GTHOm
reactant: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
kinetic law: MODEL1310110046#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2

metaM fdp c
is: http://identifiers.org/pubchem.compound/3647
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
name: D-Fructose 1,6-bisphosphate
initial concentration: 1.0
is: C00354
type: Species
constant: false
is: CHEBI:16905
is: SBO:0000247
boundary condition: false
is: HMDB01058

http://identifiers.org/biomodels.db/MODEL1310110046#_5d2d8190_612a_42a2_9106_9983c0459c27
boundary condition: true
is: Q8WWX8
name: SLC5A11
initial amount: NaN
is encoded by: hsa:115584
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_c37143a4_bf07_4b6b_9b8c_c44807d2c96a
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7498
initial concentration: NaN
name: XDH
has only substance units: false
constant: false
type: Species
is: P47989
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_a23f7cb6_89e7_4548_85c6_f22897e10436
name: GALNT10
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:55568
constant: false
type: Species
is: SBO:0000252

metaM ksi deg16 l
boundary condition: false
is: SBO:0000247
is: CHEBI:16953
constant: false
name: keratan sulfate I, degradation product 16
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
is: HMDB00812
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaM pail3p hs c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58088
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM ppi m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00013
name: Diphosphate
has only substance units: false
constant: false
type: Species
is: CHEBI:33019
is: HMDB00250
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

http://identifiers.org/biomodels.db/MODEL1310110046#_6ade1c87_8797_468e_8fe1_9d1bb14efb84
initial concentration: NaN
is encoded by: hsa:AA081045
is: SBO:0000252
type: Species
name: _AA081045_1_c
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaR SADT
is described by: ECO:0000269
product: MODEL1310110046#
type: Reaction
name: sulfate adenylyltransferase
is: SBO:0000176
modifier: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110046#
fast: false

metaM nadph c
constant: false
is: CHEBI:57783
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
boundary condition: false
is: C00005
initial amount: NaN
type: Species
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221

http://identifiers.org/biomodels.db/MODEL1310110046#_b4faac92_b0c7_4215_9ef5_bc3c6ea6a0cf
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: SLC19A3
is encoded by: hsa:80704
has only substance units: false
initial amount: NaN
type: Species
is: Q9BZV2

metaR G12MT1 L
product: MODEL1310110046#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_f03abf33_4e43_4098_b6d7_07d1a8a05fa6
is: Q709F0
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:84129
initial amount: NaN
name: ACAD11

metaR FAOXC225m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR ASPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
kinetic law: MODEL1310110046#
name: diffusion of aspartate into blood
reversible: true
product: MODEL1310110046#
is described by: ECO:0000134
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_60599673_380c_4fee_a555_476353fee6ea
boundary condition: true
is: Q93088
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:635
name: BHMT
initial amount: NaN

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM csn e
boundary condition: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
type: Species
is: CHEBI:16040
constant: false
initial amount: NaN
is: HMDB00630
name: cytosine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR 34DHXMANDACOX NADP
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
product: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false

metaM ppi n
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
type: Species
is: HMDB00250
has only substance units: false
boundary condition: false
is: SBO:0000247
name: diphosphate(3-)
is: CHEBI:33019
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_209ba04a_d291_49ca_803a_9262c0d86dcd
is encoded by: hsa:513
is encoded by: hsa:509
has part: P36542
has part: P56381
is encoded by: hsa:506
type: Species
has part: A8K092
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:498
boundary condition: true
has part: P30049
is encoded by: hsa:514
constant: false
initial amount: NaN
has only substance units: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has part: P06576

metaM amet m
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: C00019
is: HMDB01185
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
has only substance units: false
is: SBO:0000247
is: CHEBI:15414
name: S-Adenosyl-L-methionine
boundary condition: false

metaR r1759
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM udpgal g
is: CHEBI:58439
type: Species
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
constant: false
is: HMDB00302
has only substance units: false
name: UDP-D-galactose(2-)
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_c856c5af_e35f_4d24_a0c3_a99f0bf77a49
initial amount: NaN
name: _AI656480_1_m
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI656480
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_6cf65fcd_03c5_4df4_993e_c563db082c0e
boundary condition: true
initial concentration: NaN
is: Q8NFL0
has only substance units: false
is encoded by: hsa:93010
name: B3GNT7
is: SBO:0000252
type: Species
constant: false
initial amount: NaN

metaM lys L m
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
constant: false
is: CHEBI:32551
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00182
initial amount: NaN

metaR r1433
type: Reaction
reversible: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
product: MODEL1310110046#
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false

metaM adpac c
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H8O4 CHARGE: -2
name: adipic acid
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00448

metaR MALSO4tm
modifier: MODEL1310110046#
fast: false
name: Malate:sulfate antiport, mitochondrial
is described by: ECO:0000269
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
kinetic law: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_87a9805a_0cd7_40f2_8d65_130237eaee90
is: G3V5N0
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: FUT8
is: SBO:0000252
is encoded by: hsa:2530
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_65dbd1b9_b4c1_4041_b180_ec19d78c608a
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2954
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: GSTZ1

metaM 34dhmald m
initial amount: NaN
is: HMDB06242
is: C05577
name: 3,4-Dihydroxymandelaldehyde
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7903
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false

metaR PI4PLC
kinetic law: MODEL1310110046#
reversible: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol 4-phosphate phospholipase C
reactant: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000269
fast: false

metaR AMETt2m
modifier: MODEL1310110046#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
reactant: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_2ff8245f_ee3d_4987_8a33_3c4dba7e55aa
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:27034
name: ACAD8
initial concentration: NaN
is: Q6ZWP6

metaR SPHMYLNtg
name: sphingomyelin intracellular transport
reversible: true
reactant: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000

metaM malcoa r
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
name: malonyl-CoA(4-)
is: HMDB01175
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_4547a9d1_684a_4afc_bfbd_758bbe43c5f1
constant: false
is: Q9UN76
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:11254
name: SLC6A14
initial concentration: NaN
is: SBO:0000252
type: Species

metaR CREATt4 2 r
reversible: true
is described by: ECO:0000269
product: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110046#
name: Creatine transport (sodium symport) (2:1)
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR G5SADrm
is: SBO:0000176
reversible: true
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD

metaR r1434
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
name: Transport reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_c1395bcb_c169_4321_bbde_c5911bf08c61
constant: false
is: SBO:0000252
is: P00915
has only substance units: false
initial concentration: NaN
name: CA1
initial amount: NaN
is encoded by: hsa:759
boundary condition: true
type: Species

metaR OCT11EFATP
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR r1540
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
fast: false
type: Reaction

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR HAS1
name: hyaluronan synthase
product: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.212

http://identifiers.org/biomodels.db/MODEL1310110046#_2d5d1275_04dd_4aef_8a8b_3aeedbaf57c4
name: BCAT1
is encoded by: hsa:586
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: P54687
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_55f5938e_fcc5_4880_8a99_ea9c3abf1823
name: HAS2
initial concentration: NaN
is: Q92819
is encoded by: hsa:3037
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR GLUt2m
is described by: ECO:0000269
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000185
name: L-glutamate reversible transport via proton symport, mitochondrial
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110046#
reversible: true

metaR CYTK3n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
modifier: MODEL1310110046#
reversible: true
is described by: ECO:0000269
product: MODEL1310110046#
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110046#

metaM 7dhchsterol r
initial amount: NaN
name: cholesta-5,7-dien-3beta-ol
is: CHEBI:17759
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
constant: false
initial concentration: 1.0
is: HMDB00032
has only substance units: false

metaM uacgam g
is: CHEBI:57705
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
is: HMDB00290

metaM btamp m
constant: false
is: SBO:0000247
name: Biotinyl-5'-AMP
boundary condition: false
initial amount: NaN
is: HMDB04220
is: CHEBI:3110
initial concentration: 1.0
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
type: Species

metaM acetol c
type: Species
initial amount: NaN
name: hydroxyacetone
is: HMDB06961
boundary condition: false
has only substance units: false
is: CHEBI:27957
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR PI45P3K
type: Reaction
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
reactant: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
reversible: false

metaM xu1p D c
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB06534
name: D-Xylulose 1-phosphate

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaM ppa e
is: HMDB00237
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:17272
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: propionate

metaR PTE3x
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
name: peroxisomal acyl-CoA thioesterase
is: SBO:0000176
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_14ccf06f_fb4c_4373_af60_f6076b4b6aa4
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _286297_1_c
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:286297

metaM adpcoa x
is: SBO:0000247
initial concentration: 1.0
is: C14143
boundary condition: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: adipoylcoa
is: HMDB04047

metaR r1604
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksi deg6 l
name: keratan sulfate I, degradation product 6
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:12936
initial amount: NaN
has only substance units: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaR HAS2
modifier: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase
reactant: MODEL1310110046#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110046#
fast: false

MODEL1310110046
reaction: metaR r1423
species: metaM bilirub r
reaction: metaR EX retinol 9 cis LPAREN e RPAREN
reaction: metaR FAOXC183C163Gm
species: metaM hdcea e
reaction: metaR GLYtp
species: metaM pcreat c
species: metaM tsul c
reaction: metaR ARABR
reaction: metaR F6Tg
reaction: metaR EX hco3 LPAREN e RPAREN
species: metaM pnto R c
reaction: metaR SACCD4m
species: metaM nicrnt c
reaction: metaR ALAGLNexR
reaction: metaR DNDPt35m
species: metaM dgmp c
reaction: metaR C181OHc
species: metaM adpac c
reaction: metaR r0796
species: metaM HC01603 c
species: metaM fru c
reaction: metaR CYTK10n
reaction: metaR SEBCOACROT
species: metaM ksi deg24 l
reaction: metaR MEVK1c
reaction: metaR ALACYSNaEx
species: metaM dsmsterol r
species: metaM cgly e
species: metaM leuktrC4 e
reaction: metaR S6TASE15ly
reaction: metaR FAOXTC122m
reaction: metaR S4TASE2ly
reaction: metaR DOLPMT2 Ler
species: metaM strdnccoa c
reaction: metaR GLNtN1
reaction: metaR r2318
species: metaM ptdcacrn m
reaction: metaR CYTK6
species: metaM ala L e
species: metaM dlnlcgcrn m
reaction: metaR r1487
species: metaM ser D e
reaction: metaR NACHEX19ly
reaction: metaR r2397
reaction: metaR DCYTD
reaction: metaR r0744
reaction: metaR ACACt2
species: metaM glc D e
reaction: metaR KSII CORE2t
species: metaM lnlncgcoa m
reaction: metaR O2Stn
reaction: metaR THRALANaEx
reaction: metaR GLYSNAT5tc
reaction: metaR RE2079R
reaction: metaR ALAtN1
reaction: metaR RE1836X
species: metaM sucsal m
reaction: metaR ARACHCRNt
reaction: metaR NDPK1n
reaction: metaR r0974
species: metaM xolest2 hs e
reaction: metaR NACHEX12ly
reaction: metaR GALASE9ly
reaction: metaR r1616
reaction: metaR r2097
reaction: metaR FAOXC164m
species: metaM 7dhchsterol r
reaction: metaR GLYCLTtp
reaction: metaR EX HC00250 LPAREN e RPAREN
species: metaM cs e deg6 l
reaction: metaR r2508
reaction: metaR r0718
reaction: metaR BHMT
reaction: metaR r2367
reaction: metaR RDH3a
reaction: metaR NDPK6n
reaction: metaR ELAIDCPT2
reaction: metaR r1020
reaction: metaR TYRt

metaR KHK
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
name: ketohexokinase
reactant: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.3

http://identifiers.org/biomodels.db/MODEL1310110046#_b0399426_7163_4e1a_a33b_1c530c8fcadb
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2678
name: GGT1
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR BCDO
is: SBO:0000176
product: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
reactant: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.36
name: beta-Carotene dioxygenase

http://identifiers.org/biomodels.db/MODEL1310110046#_c8bc5516_41ff_411b_905c_7ce4b517e54c
initial amount: NaN
is: A5PKZ1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:11227
has only substance units: false
name: GALNT5
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_ee83a9d6_dc6b_4250_94cf_7132c0e325d0
constant: false
name: GAMT
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q14353
is encoded by: hsa:2593
initial concentration: NaN

metaM gchola x
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
initial concentration: 1.0
name: glycocholate
is: CHEBI:58235
type: Species
is: HMDB00138

metaR ADPACDAc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR r1603
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_dec73cd1_b8ed_4a76_a0aa_f16ad363b54b
is: P49327
is encoded by: hsa:2194
name: FASN
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaR GPDDA1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
reversible: false
reactant: MODEL1310110046#
type: Reaction
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
is: SBO:0000176
product: MODEL1310110046#

metaR UDPGLCAter
modifier: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
reversible: true
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD

metaR r0191
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.24
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reversible: false
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_3807f2e8_ef37_4732_915c_358226dfe866
boundary condition: true
is encoded by: hsa:3074
initial concentration: NaN
is: P07686
type: Species
has only substance units: false
name: HEXB
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_93f361c6_2493_4b0a_a35f_ffbf138502ce
name: ALAS1
is encoded by: hsa:211
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q5JAM2
has only substance units: false
is: SBO:0000252
constant: false

metaM ksii core4 deg2 l
initial amount: NaN
boundary condition: false
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
has only substance units: false
constant: false
name: keratan sulfate II (core 4-linked), degradation product 2
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936
type: Species

metaR FACOAL184
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
product: MODEL1310110046#

metaR CSNATer
product: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
name: carnitine O-acetyltransferase, endolasmic reticulum
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
reversible: true
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110046#_2e79fd0a_295a_4de7_9c0c_c91df5afea17
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:3795
type: Species
name: KHK
is: P50053
has only substance units: false
boundary condition: true

metaR FAOXC164m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR ACETONEt2
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: acetone transport via proton symport
kinetic law: MODEL1310110046#

metaR FAOXC225x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_31f19fb7_8d63_4c02_8b36_03fc4a903c65
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P40394
type: Species
boundary condition: true
is encoded by: hsa:131
name: ADH7
has only substance units: false

metaR r1602
kinetic law: MODEL1310110046#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM ppa c
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:17272
name: propionate
initial amount: NaN
is: SBO:0000247

metaR r0629
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.6.1.22
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110046#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true
product: MODEL1310110046#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d68d9f1d_e172_4607_bf0d_7c5d031da1db
initial concentration: NaN
initial amount: NaN
name: ATP1B2
type: Species
is encoded by: hsa:482
is: SBO:0000252
constant: false
boundary condition: true
is: P14415
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_07308fd9_62fc_49e3_b949_3568eefbff28
is encoded by: hsa:471
name: ATIC
type: Species
boundary condition: true
initial amount: NaN
is: P31939
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR P4507A1r
is version of: http://identifiers.org/ec-code/1.14.13.17
reversible: false
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
is described by: ECO:0000269
name: cytochrome P450, family 7, subfamily A, polypeptide 1
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
type: Reaction

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_b5d2dc92_11e5_43c6_b3f5_e23330cf59a6
name: NDUFB3
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q6IB80
is encoded by: hsa:4709

metaR GCCcm
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoylprotein), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: true
type: Reaction
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110046#
is described by: ECO:0000269

metaM 3dpdhb me m
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:50776
is: SBO:0000247
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_8d4d6cb3_154c_41d9_be70_d2710f2e5b64
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: Q92569
constant: false
name: PIK3R3
is: SBO:0000252
is encoded by: hsa:8503

metaM ser L m
initial amount: NaN
is: CHEBI:17115
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
has only substance units: false
is: HMDB00187
name: L-serine
type: Species
constant: false
boundary condition: false

metaR GLNALANaEx
reversible: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000269
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185

metaR MG1er
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110046#
fast: false
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.106
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#

metaR RE0691C
fast: false
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: RE0691
product: MODEL1310110046#

metaM ppi e
is: CHEBI:33019
is: C00013
initial amount: NaN
initial concentration: 1.0
name: Diphosphate
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM acald m
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: acetaldehyde
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
initial concentration: 1.0
initial amount: NaN
type: Species

metaM lnlncacrn m
name: alpha-linolenyl carnitine
is: HMDB06319
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR RE1519M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1519
fast: false

metaR r1544
reversible: true
reactant: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#

metaR r1600
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false

metaR FAOXC12DCx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR r0627
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reversible: true
fast: false
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176

metaM mi34p c
name: 1D-myo-Inositol 3,4-bisphosphate
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:28858
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
is: SBO:0000247
is: HMDB06235
initial amount: NaN

metaM lys L c
is: CHEBI:32551
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00182
boundary condition: false

metaR PGLer
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
kinetic law: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110046#
reversible: false
is described by: ECO:0000269
name: 6-phosphogluconolactonase, endoplasmic reticulum
fast: false

metaR RE3272N
reactant: MODEL1310110046#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
fast: false
name: RE3272

http://identifiers.org/biomodels.db/MODEL1310110046#_3544b928_f373_4d0e_8aa2_1be61b711410
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:112
has only substance units: false
is: O43306
boundary condition: true
name: ADCY6
is: SBO:0000252

metaR r1752
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000

metaM tetpent3 c
name: tetracosapentaenoic acid, n-3
constant: false
boundary condition: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB06323
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR NACHEX21ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110046#
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_abde486f_7fc8_4040_9004_5950d16c3ec4
is: SBO:0000252
boundary condition: true
type: Species
name: GPX1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2876
constant: false

metaR DOPASULT
fast: false
reversible: false
is: SBO:0000176
type: Reaction
name: Dopamine Sulfotransferase
is described by: ECO:0000269
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
product: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_5386ad7f_38de_4f64_afe6_eee4534e6f73
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:5728
boundary condition: true
type: Species
is: F6KD01
name: PTEN

http://identifiers.org/biomodels.db/MODEL1310110046#_33e2fe40_4124_4b58_8739_160c52e73bb1
type: Species
boundary condition: true
is: Q9HBH5
name: RDH14
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:57665
has only substance units: false

metaR FAOXC102C103m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR PHEMEtm
is: SBO:0000185
kinetic law: MODEL1310110046#
name: Heme transport to cytosol
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
type: Reaction
fast: false

metaR DAGKn hs
is version of: http://identifiers.org/ec-code/2.7.1.107
fast: false
name: Diacylglycerol phosphate kinase (homo sapiens)
is described by: ECO:0000269
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM ppi c
type: Species
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3
is: C00013
initial concentration: 1.0
initial amount: NaN
name: Diphosphate
is: HMDB00250
has only substance units: false
boundary condition: false
is: CHEBI:0
constant: false

metaR TMNDNCCRNt
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110046#
fast: false
product: MODEL1310110046#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR ECOAH1m
type: Reaction
product: MODEL1310110046#
fast: false
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110046#_aa52bfd3_a155_4620_9c51_f49dcdcee83e
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _H17063_1_m
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:H17063

metaR PACCOAL
name: phenylacetate-CoA ligase
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#

metaR r1546
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110046#
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR GASNASEly
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
reversible: false
name: glycosylasparaginase, lysosomal
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.5.1.26

metaM lys L e
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
boundary condition: false
name: L-lysinium(1+)
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:32551

metaR ETFQO
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.5.1
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#

metaR BUTt2r
name: Butyrate transport via proton symport, reversible
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#

metaR RE1526M
reversible: true
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
name: RE1526
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
fast: false
product: MODEL1310110046#

metaR SGALSIDEtl
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
name: sgalside hs intracellular transport
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true

metaR EX adp
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaR HSD17B4x
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110046#
is described by: ECO:0000269
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is: SBO:0000176
modifier: MODEL1310110046#
reversible: false
fast: false
type: Reaction
product: MODEL1310110046#

metaM gacpail hs c
initial amount: NaN
initial concentration: 1.0
is: HMDB00128
is: SBO:0000247
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species
is: CHEBI:16344
constant: false
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1d07fda2_b568_4f16_a6a0_15222e714985
is encoded by: hsa:5320
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: PLA2G2A
constant: false
is: P14555
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_1e6c915c_f073_4353_b786_5ee1b2122794
is encoded by: hsa:2977
type: Species
is: SBO:0000297
initial amount: NaN
boundary condition: true
name: GUCY1A2:GUCY1B3
constant: false
has part: Q02153
has only substance units: false
is encoded by: hsa:2983
initial concentration: NaN
has part: P33402

metaR r1547
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110046#

metaR r0236
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.6
product: MODEL1310110046#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#

metaR APOC LYS BTNP
reactant: MODEL1310110046#
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: proteolysis of apoC-Lys-btn
product: MODEL1310110046#

metaR PSSA1 hs
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reversible: true
type: Reaction
modifier: MODEL1310110046#
is: SBO:0000176
name: Phosphatidylserine synthase homo sapiens
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.8.29
is described by: ECO:0000269
fast: false

metaM dece4coa x
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: 4-decenoylcoa
has only substance units: false
type: Species
boundary condition: false
is: HMDB02145
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_9a9e4ebc_9042_4d6b_88dd_8f09f8e11158
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:492
constant: false
name: ATP2B3
is: SBO:0000252
is: Q16720

metaR r0381
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
reversible: true
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
type: Reaction

metaM prpncoa m
is: CHEBI:57367
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
name: acryloyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
is: HMDB02307
constant: false
boundary condition: false
type: Species

metaR r1587
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
type: Reaction

metaR r0630
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
product: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176

metaM ptdcacrn m
boundary condition: false
has only substance units: false
type: Species
is: HMDB01721
name: pendtadenoyl carnitine
initial concentration: 1.0
is: CHEBI:15811
is: SBO:0000247
constant: false
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_db213313_3a82_4d3b_b0b3_b1f98f49344d
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: RBKS
type: Species
is: Q9H477
initial concentration: NaN
is encoded by: hsa:64080
constant: false
has only substance units: false

metaM dgdp c
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00361
constant: false
boundary condition: false
is: CHEBI:58595
name: dGDP
initial amount: NaN
has only substance units: false
is: HMDB00960

metaR r0656
fast: false
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_718775ae_7a9d_4cb2_882a_367aa7fbb819
type: Species
name: ATP5G1
initial concentration: NaN
is: P05496
is encoded by: hsa:516
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR CMPACNAtg
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
name: CMP-Sia Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
fast: false
kinetic law: MODEL1310110046#

metaM eicostetcoa c
name: eicosatetranoyl coenzyme A
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
boundary condition: false
is: C16164
initial amount: NaN
type: Species
initial concentration: 1.0

metaM lpro m
initial amount: NaN
is: CHEBI:15804
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
name: Lipoylprotein
type: Species

metaR r1617
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_a034bf9d_ba87_43ca_bc2a_93cbe44ee4be
initial amount: NaN
is: F5H8B1
is encoded by: hsa:5833
boundary condition: true
name: PCYT2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR r1586
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110046#

metaR biomass reaction
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reactant: MODEL1310110046#
name: biomass_reaction
is: SBO:0000185
product: MODEL1310110046#
fast: false
reversible: false

metaR C6COAt
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaR r2090
product: MODEL1310110046#
reactant: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM ksi pre21 g
is: C00130
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
type: Species
initial amount: NaN
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 21

metaM dd3coa x
initial amount: NaN
is: SBO:0000247
is: HMDB04257
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
constant: false
has only substance units: false
name: 3-dodecenoylcoa
initial concentration: 1.0
boundary condition: false
type: Species

metaM c12dc e
is: HMDB04047
is: SBO:0000247
name: dodecanedioyl carnitine
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H34NO6 CHARGE: -1
has only substance units: false
type: Species
initial concentration: 1.0
is: C14143
constant: false

metaM 4aphdob c
constant: false
is: CHEBI:58147
is: HMDB00978
boundary condition: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252

metaM ksi deg3 l
initial amount: NaN
has only substance units: false
is: HMDB00573
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: CHEBI:30825
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
boundary condition: false
name: keratan sulfate I, degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110046#_539b33ed_d21e_4652_b2ee_94be2c089871
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4514
name: COX3
is: P00414
constant: false
initial concentration: NaN

metaR r0655
reversible: true
modifier: MODEL1310110046#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.5.1.2

metaM glcur e
initial concentration: 1.0
constant: false
name: D-glucuronate
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:15748

metaR r1618
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110046#
product: MODEL1310110046#
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaR r1585
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_c1679107_076d_40cc_8a86_f9efc45da72b
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:8898
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: A6NN98
name: MTMR2

metaM noncoa m
is: HMDB13028
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: nonanoylcoa
boundary condition: false
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
is: C01942
initial concentration: 1.0

metaR AG13T7g
type: Reaction
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110046#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_b5da8964_c3fd_4001_9e72_922a5f78d460
is: SBO:0000252
boundary condition: true
is: O75251
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFS7
is encoded by: hsa:374291

http://identifiers.org/biomodels.db/MODEL1310110046#_5795f4af_62dc_4d84_bdca_36ff55d8ba01
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3283
initial amount: NaN
is: P14060
boundary condition: true
constant: false
name: HSD3B1
has only substance units: false
type: Species

metaR KCCt
type: Reaction
is: SBO:0000185
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
reversible: true
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000269
name: K+-Cl- cotransport
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_88e52c83_3732_44d2_8663_4e49e9e4c2a9
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:9061
name: PAPSS1
has only substance units: false
constant: false
is: O43252

metaR HPYRRy
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.79
name: Hydroxypyruvate reductase (NADPH)
kinetic law: MODEL1310110046#

metaR r1619
modifier: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110046#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR MECOAS1m
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
is: SBO:0000176
product: MODEL1310110046#
modifier: MODEL1310110046#
name: mesaconate--CoA ligase (GDP-forming)
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR FAOXC101C8x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_62e4ad2a_0e52_4d54_95f5_34d3c2640ea9
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6319
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: O00767
name: SCD

metaM 2hexdtricoa m
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: 2,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_c99bca8b_1867_46f9_bb7a_1e4f4897bce1
constant: false
has only substance units: false
is: Q8NEB9
name: PIK3C3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5289
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_f69a8164_2ecc_4cd2_9ef3_02f60c7463f8
is: P23677
has only substance units: false
initial amount: NaN
is encoded by: hsa:3706
type: Species
constant: false
boundary condition: true
name: ITPKA
initial concentration: NaN
is: SBO:0000252

metaR r0181
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reversible: true
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR r1584
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#

metaR RE3568C
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
name: RE3568
is: SBO:0000176
product: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
fast: false
type: Reaction

metaR SBTR
modifier: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
name: D-sorbitol reductase
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false

metaM thbpt4acam n
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02281
type: Species
initial concentration: 1.0
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
is: CHEBI:15374
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951

metaR r0186
reactant: MODEL1310110046#
reversible: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
kinetic law: MODEL1310110046#
fast: false
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_74082dc7_3f6b_4c8d_969e_b4c9d0148da8
is encoded by: hsa:8867
has only substance units: false
boundary condition: true
is: O43426
initial amount: NaN
constant: false
type: Species
name: SYNJ1
initial concentration: NaN
is: SBO:0000252

metaM sarcs e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:15611
constant: false
is: HMDB00271
name: sarcosine
has only substance units: false
is: SBO:0000247

metaR GACMTRc
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES:SAB c
reversible: true
is version of: http://identifiers.org/ec-code/2.1.1.2
name: guanidinoacetate N-methyltransferase (c)
product: MODEL1310110046#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110046#
reactant: MODEL1310110046#

metaR r1583
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
reversible: true
product: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_2d26ddc2_4891_4a33_8775_113ea3fa01d1
is: SBO:0000252
type: Species
has only substance units: false
is: P51648
name: ALDH3A2
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:224

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM alpro m
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: S-Aminomethyldihydrolipoylprotein
type: Species
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
is: CHEBI:16882
is: SBO:0000247

metaR r0634
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_01c467a6_e28a_4ca8_9fe7_d313fdad80f9
initial amount: NaN
type: Species
is: SBO:0000252
name: ACP2
is: E9PCI1
boundary condition: true
is encoded by: hsa:53
initial concentration: NaN
has only substance units: false
constant: false

metaM pheacgln c
initial amount: NaN
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB06344
has only substance units: false
constant: false
boundary condition: false

metaR r2093
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM ser L e
is: CHEBI:17115
constant: false
initial concentration: 1.0
initial amount: NaN
name: L-serine
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00187

metaR SQLEr
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000134
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.132
name: Squalene epoxidase, endoplasmic reticular (NADP)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_68814cd8_7c40_4361_9699_1249a079d051
is: Q9BW60
is encoded by: hsa:64834
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: ELOVL1
is: SBO:0000252
boundary condition: true
type: Species

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_253c88df_c372_42f8_9001_e3449a2a2a2c
is encoded by: hsa:84076
type: Species
initial amount: NaN
boundary condition: true
is: Q9H0I9
has only substance units: false
name: TKTL2
is: SBO:0000252
initial concentration: NaN
constant: false

metaM ala L e
initial amount: NaN
type: Species
name: L-alanine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
constant: false
has only substance units: false
is: HMDB00161

metaR PRGNLONESULT
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110046#
reversible: false
is: SBO:0000176
fast: false
name: steroid sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.14
is version of: http://identifiers.org/ec-code/2.8.2.2
product: MODEL1310110046#
modifier: MODEL1310110046#

metaM Lcystin e
boundary condition: false
name: L-cystine
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00192
constant: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
is: SBO:0000247
has only substance units: false

metaM HC01401 x
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
type: Species
constant: false
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
has only substance units: false
is: CHEBI:27668
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5367e33f_148f_49b0_bca0_572c0323ba2b
constant: false
is: SBO:0000252
name: ADSS
is: P30520
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:159
has only substance units: false

metaM CE2422 m
initial amount: NaN
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: CHEBI:28387
has only substance units: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
constant: false
is: HMDB11123
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM gluside hs r
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
constant: false
name: D-glucosyl-N-acylsphingosine
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18368
boundary condition: false
initial amount: NaN

metaR r0633
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.7.7.3
fast: false
reversible: true
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_975f325f_5c00_4241_85d5_5aef6effe803
name: EHHADH
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: Q9NY65
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110046#_410558e2_1cf3_4168_8102_0240403c9a14
constant: false
initial concentration: NaN
is encoded by: hsa:3795
is: Q6IBK2
is: SBO:0000252
boundary condition: true
name: KHK
initial amount: NaN
has only substance units: false
type: Species

metaR FAOXTC122TC101m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaM hs deg19 l
constant: false
is: CHEBI:17180
initial concentration: 1.0
name: heparan sulfate, degradation product 19
type: Species
boundary condition: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: HMDB01352
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_3bfd7b6e_6882_450a_9af1_d0325b462d6a
constant: false
initial concentration: NaN
name: PLCB1
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23236
boundary condition: true

metaR r2094
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#

metaM pail3p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58088
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_b1bced7b_8d70_45d8_abe4_bf9b068822ff
constant: false
is encoded by: hsa:5152
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: PDE9A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_1e9e71ca_ccbc_4b2c_844f_895a136f2ffc
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1351
boundary condition: true
constant: false
is: Q53XN1
name: COX8A
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_46df5abc_6365_4a43_b074_af6a88cdc507
constant: false
name: SLC8A3
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:6547

metaR r1581
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
fast: false

metaR NDP8ex
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110046#
reversible: false
name: nucleoside-diphosphatase (UTP), extracellular
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.6.1.6

metaM sarcs c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:3513
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0
has only substance units: false
initial amount: NaN
constant: false
name: Sarcosine
is: HMDB00271
is: C00213

metaR UAGALDP
type: Reaction
product: MODEL1310110046#
name: UDP-N-acetylgalactosamine diphosphorylase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_d8e7b35b_19e9_43dc_81e0_c9a998485d3f
type: Species
name: SULT1A1
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:6817

metaM arachd r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
name: arachidonate
type: Species
is: CHEBI:32395
boundary condition: false
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247

metaM ser L c
is: SBO:0000247
is: HMDB00187
is: CHEBI:17115
initial concentration: 1.0
name: L-serine
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
type: Species

metaM gacpail hs r
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:16344
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00128
name: glucosaminyl-acylphosphatidylinositol

http://identifiers.org/biomodels.db/MODEL1310110046#_282d2813_683b_4842_bcee_9c18c2b6c327
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: HK1
boundary condition: true
is encoded by: hsa:3098
type: Species
initial amount: NaN
is: P19367

metaM pheacgln e
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: SBO:0000247
type: Species
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: HMDB06344
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r2091
modifier: MODEL1310110046#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR CYTK7n
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP),nuclear
kinetic law: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
reversible: true
product: MODEL1310110046#

metaR H2Oter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O endoplasmic reticulum transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
fast: false
product: MODEL1310110046#
type: Reaction

metaR r1580
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110046#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_8128fcb5_fb86_4d78_9b1a_b266b5afe38b
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:3295
constant: false
is: E9PB82
initial concentration: NaN
name: HSD17B4
is: SBO:0000252

metaM 35cgmp n
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01314
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: SBO:0000247
is: CHEBI:57746
initial concentration: 1.0
name: 3',5'-cyclic GMP(1-)
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_77930a41_3b74_495f_a662_500afa07c5f7
is encoded by: hsa:AL525798
name: _AL525798_1_c
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaM ala L c
is: HMDB00161
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
name: L-alanine

metaR FAS80COA L
is: SBO:0000176
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
reactant: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction

metaM Lcystin c
name: L-cystine
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
is: HMDB00192
has only substance units: false
constant: false
is: CHEBI:16283
is: SBO:0000247

metaM CE5236 n
boundary condition: false
constant: false
name: O2'-4a-cyclic-tetrahydrobiopterin
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: HMDB03952
is: CHEBI:28002

metaM glcur c
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
is: SBO:0000247
boundary condition: false
name: D-glucuronate
type: Species
initial amount: NaN
is: CHEBI:15748
initial concentration: 1.0
constant: false
has only substance units: false

metaM hs deg15 l
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
type: Species
is: CHEBI:16126
name: heparan sulfate, degradation product 15
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_1188ccb8_85a6_436b_ba42_d89215d0a2b1
name: PRDX1
boundary condition: true
is encoded by: hsa:5052
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaM c12dc c
name: dodecanedioyl carnitine
is: C14143
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C19H34NO6 CHARGE: -1
is: HMDB04047
has only substance units: false

metaR r2092
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
fast: false
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_e02e7b58_ddba_4cdc_a627_4f6126dc75ad
initial amount: NaN
is encoded by: hsa:AI926493
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: _AI926493_1_c
has only substance units: false
is: SBO:0000252

metaR r2097
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110046#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
fast: false

metaR UDPG4E
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
name: UDPglucose 4-epimerase
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
is: SBO:0000176

metaM acetone e
constant: false
is: SBO:0000247
is: HMDB01659
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
name: acetone
is: CHEBI:15347
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_078120ee_6648_4f43_a75d_25479d800f4a
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:51227
type: Species
initial concentration: NaN
has only substance units: false
name: PIGP

metaR sink citr LPAREN c RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: citrulline sink
type: Reaction

metaR KAS8
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
type: Reaction
is described by: ECO:0000269
product: MODEL1310110046#
modifier: MODEL1310110046#
name: b-ketoacyl synthetase (palmitate, n-C16:0)

http://identifiers.org/biomodels.db/MODEL1310110046#_0f57964f_b779_4209_ae13_80103a871cfc
name: NDUFA5
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:4698
is: SBO:0000252
has only substance units: false
is: Q16718
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_0ec5970d_77bb_4c00_a810_6cbee66e3ca2
initial concentration: NaN
is encoded by: hsa:2678
name: GGT1
boundary condition: true
is: P19440
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252

metaM hLkynr c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17380
constant: false
has only substance units: false
boundary condition: false
is: HMDB11631
type: Species
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
name: 3-hydroxy-L-kynurenine
is: SBO:0000247

metaR FAOXC140
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
product: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_4dc56222_d6bb_43fd_aabf_5cfaa84bb0f9
has only substance units: false
initial amount: NaN
name: LYZL1
is: SBO:0000252
is encoded by: hsa:84569
type: Species
initial concentration: NaN
boundary condition: true
is: Q6UWQ5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_758f8de4_6cc7_45f7_9cd3_d79f640b8fe3
has only substance units: false
is: Q8TCG5
type: Species
name: CPT1C
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:126129
constant: false
initial amount: NaN

metaR r0389
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
product: MODEL1310110046#

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_7ad6af54_14a1_4d18_9752_5ab5547bec9c
initial amount: NaN
constant: false
name: CKM
is: SBO:0000252
type: Species
boundary condition: true
is: B2R892
has only substance units: false
is encoded by: hsa:1158
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_742de5ea_4433_4da4_b472_0c6cab947c43
initial concentration: NaN
is encoded by: hsa:9517
name: SPTLC2
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: O15270
boundary condition: true

metaR IDOURtly
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
is: SBO:0000185
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
type: Reaction
name: iduronate transport into lysososme
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reversible: true

metaR RE3243R
is: SBO:0000176
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
type: Reaction
reversible: true
name: RE3243

metaM ksi pre2 g
is: C00130
constant: false
is: SBO:0000247
is: HMDB00175
boundary condition: false
type: Species
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 2
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial concentration: 1.0

metaR RE3050R
reactant: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
product: MODEL1310110046#
fast: false
name: RE3050
reversible: true
type: Reaction
is described by: ECO:0000000

metaM c8dc e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C15H26NO6 CHARGE: -1
name: suberyl carnitine
is: HMDB00705
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_a9835913_eaff_460e_87e4_d6682cbc20c8
type: Species
name: ST3GAL2
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q16842
is encoded by: hsa:6483
constant: false
has only substance units: false

metaM for e
is: CHEBI:15740
has only substance units: false
boundary condition: false
name: formate
type: Species
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
initial amount: NaN
initial concentration: 1.0
constant: false

metaR CMPACNAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
name: CMP-Sia nuclear export
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#

metaR r2098
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

metaR GALASE3ly
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM duri c
has only substance units: false
is: CHEBI:16450
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
constant: false
is: HMDB00012
is: SBO:0000247
is: C00526
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_60e981a5_a61d_4fdf_835d_0e2b916f84cb
constant: false
name: ALDH18A1
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5832
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P54886

http://identifiers.org/biomodels.db/MODEL1310110046#_4a10041d_0b75_4e0b_9bc9_f7f494b7eb1c
initial concentration: NaN
has only substance units: false
name: CHST1
initial amount: NaN
boundary condition: true
is encoded by: hsa:8534
constant: false
is: O43916
type: Species
is: SBO:0000252

metaR FAOXC163x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_08d658fb_ce66_4121_baf5_f1ea465f4cef
constant: false
initial amount: NaN
initial concentration: NaN
name: ALG8
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:79053
is: A6NDW6

metaR r0388
reactant: MODEL1310110046#
type: Reaction
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
reversible: true
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_c049fa41_968a_40a8_8796_7a1e1b1b0ece
is: P22830
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2235
name: FECH

metaM dgdp m
type: Species
has only substance units: false
constant: false
is: HMDB00960
name: dGDP(2-)
is: CHEBI:58595
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false

metaM dump c
name: dUMP
constant: false
is: C00365
is: CHEBI:246422
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
has only substance units: false
is: HMDB01409
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

metaM acetone c
constant: false
is: SBO:0000247
is: HMDB01659
type: Species
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
boundary condition: false
initial amount: NaN
name: acetone
is: CHEBI:15347

metaR r2095
fast: false
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM 34dhpha c
is: HMDB01336
has only substance units: false
initial amount: NaN
is: CHEBI:17612
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
constant: false
name: (3,4-dihydroxyphenyl)acetate
boundary condition: false

metaM adpac x
is: SBO:0000247
is: HMDB00448
name: adipic acid
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C6H8O4 CHARGE: -2
constant: false
has only substance units: false

metaR DMHPTCRNCPT2
is: SBO:0000176
name: 2,6 dimethylheptanoly CoA carnitine transferase
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
reactant: MODEL1310110046#
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_396921f0_77fb_4ca3_8a53_54bf02585353
constant: false
is: SBO:0000252
type: Species
name: ACADS
has only substance units: false
initial concentration: NaN
is: P16219
initial amount: NaN
boundary condition: true
is encoded by: hsa:35

metaM 5htrp c
name: 5-hydroxy-L-tryptophan
boundary condition: false
type: Species
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: HMDB00472
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:17780
constant: false

metaM ksii core4 deg3 l
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110046#_b709bb3d_bd6c_4744_9c9c_f18f29e0b06c
is encoded by: hsa:6487
constant: false
initial concentration: NaN
name: ST3GAL3
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR NACHEX18ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#

metaR r2096
modifier: MODEL1310110046#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM for c
name: Formate
constant: false
is: CHEBI:15740
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
is: C00058
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00142
initial amount: NaN

metaR RPEc
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000176
name: ribulose 5-phosphate 3-epimerase
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_49278111_e2a3_44e8_956f_ceb9c82ed2f9
initial concentration: NaN
name: ATP5D
constant: false
initial amount: NaN
is encoded by: hsa:513
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM Asn X Ser Thr l
has only substance units: false
is: C01342
is: CHEBI:28938
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
type: Species
is: HMDB00051
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: protein-linked asparagine residue (N-glycosylation site)

metaR AACOAT
reactant: MODEL1310110046#
is: SBO:0000176
name: Acetoacetyl-CoA:acetate CoA-transferase
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_63416113_47ce_4e70_a387_1d0070410a69
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: PANK3
has only substance units: false
initial amount: NaN
is: Q9H999
is encoded by: hsa:79646
boundary condition: true

metaM Sfglutth c
constant: false
boundary condition: false
is: CHEBI:57688
is: SBO:0000247
has only substance units: false
is: HMDB01550
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
name: S-formylglutathionate(1-)
type: Species
initial concentration: 1.0
initial amount: NaN

metaM gluside hs c
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
is: SBO:0000247

metaR r0386
reversible: false
is: SBO:0000176
reactant: MODEL1310110046#
type: Reaction
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
fast: false

metaR TTDCAtr
name: tetradecanoate (transport)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110046#
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1c3aa3a5_0a83_4a71_a345_7237bc5c6ae2
type: Species
boundary condition: true
has only substance units: false
is: P00325
is encoded by: hsa:125
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ADH1B

metaM sarcs m
is: HMDB00271
is: C00213
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Sarcosine
is: CHEBI:15611
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_0fa94941_81c0_4137_a0f7_48d3040b8bbe
is encoded by: hsa:18
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is: P80404
name: ABAT

metaR DOLPGT1 Ler
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.267
fast: false
reversible: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000176

metaR F1PGT
product: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.30
is: SBO:0000176
modifier: MODEL1310110046#
is described by: ECO:0000000
name: fucose-1-phosphate guanylyltransferase
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#

metaR r0937
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
name: Transport reaction
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaM chito2pdol L c
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
is: CHEBI:12427
is: HMDB01196
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_f34f1122_e520_4c3b_955f_08c7e52033a1
constant: false
is: Q14542
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: SLC29A2
is encoded by: hsa:3177
initial amount: NaN
initial concentration: NaN

metaR FAOXC17C15m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaR r0652
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
reactant: MODEL1310110046#

metaR ALASm
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110046#
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.29
name: 5-aminolevulinate synthase
is version of: http://identifiers.org/ec-code/2.3.1.37

http://identifiers.org/biomodels.db/MODEL1310110046#_e2efafc9_442d_4568_8ba6_880cf6db0304
type: Species
boundary condition: true
is: Q9Y2B2
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9487
is: SBO:0000252
constant: false
name: PIGL

metaR r0936
product: MODEL1310110046#
name: Transport reaction
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_fa110909_cd09_4b7b_b783_7ddc40ea88bf
type: Species
boundary condition: true
is encoded by: hsa:10087
is: Q9Y5P4
name: COL4A3BP
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaR DNDPt9m
reversible: false
kinetic law: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110046#
name: dADP transport via dTDP antiport
type: Reaction
reactant: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_a1441d61_2d68_4cf6_b048_d713307d56a6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10229
is: Q99807
name: COQ7
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_ec1272be_79a3_43c8_9c14_d5903b5da6c9
name: PYCR2
boundary condition: true
type: Species
is encoded by: hsa:29920
is: SBO:0000252
is: Q96C36
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_a081fb1c_754f_4282_9d4f_550bb09788b3
is encoded by: hsa:10587
has only substance units: false
type: Species
name: TXNRD2
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9NNW7
is: SBO:0000252

metaR PGMT
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
name: phosphoglucomutase

metaR r0074
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
product: MODEL1310110046#
reversible: true
is: SBO:0000176
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction

metaR S6TASE23ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110046#_d19b4049_23ac_4862_9e27_95653f0ed97e
boundary condition: true
constant: false
type: Species
is: P51570
initial concentration: NaN
name: GALK1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:2584

metaR r0651
type: Reaction
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
fast: false
product: MODEL1310110046#

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR r2099
kinetic law: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110046#
modifier: MODEL1310110046#

metaM 44mzym r
initial amount: NaN
is: CHEBI:18364
name: 14-demethyllanosterol
is: HMDB01286
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108

metaR HMGCOAtm
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000185

metaR r0650
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110046#
is: SBO:0000176

metaM m7masnB r
is: SBO:0000247
notes: FORMULA: C64H107N2O50X CHARGE: 0
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C05881
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_408f8261_70d3_4c9b_a64d_20ba4ca1d683
initial concentration: NaN
initial amount: NaN
name: GOT1
boundary condition: true
constant: false
is: P17174
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2805

http://identifiers.org/biomodels.db/MODEL1310110046#_3af205ab_8235_4393_9b75_f7d3b7424ee7
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:221823
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: PRPS1L1

metaR FATP7t
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.7
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110046#

metaR G14T16g
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
reactant: MODEL1310110046#

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaM c8dc c
type: Species
constant: false
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: suberyl carnitine
is: SBO:0000247
is: HMDB00705

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM gluside hs g
is: SBO:0000247
type: Species
constant: false
is: CHEBI:18368
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR KYNATESYN
reversible: false
is: SBO:0000176
product: MODEL1310110046#
type: Reaction
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
reactant: MODEL1310110046#

metaR PIPLCn
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110046#
name: phosphatidylinositol phospholipase C, nucleus
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
kinetic law: MODEL1310110046#

metaM HC01501 c
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
initial amount: NaN
boundary condition: false
is: CHEBI:33539
type: Species
is: SBO:0000247
constant: false
name: hydroxidodioxidosulfidosulfate(1-)
initial concentration: 1.0
has only substance units: false

metaM 13dpg c
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535
is: SBO:0000247
name: 3-Phospho-D-glyceroyl phosphate
is: HMDB01270
is: CHEBI:57604
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
has only substance units: false
boundary condition: false
is: C00236

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR r1421
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
reversible: true
name: Free diffusion

metaR AG13T10g
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
type: Reaction
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_c10b48fa_0aae_4fcc_86fc_827aef719f74
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AI972237_1_c
has only substance units: false
is encoded by: hsa:AI972237
constant: false
boundary condition: true

metaR ACHtn
product: MODEL1310110046#
name: Acetylcholin transport, nuclear trhough pores
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it

metaR RPI
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/5.3.1.6
reversible: true
name: ribose-5-phosphate isomerase
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR NTD5
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: 5'-nucleotidase (dTMP)
is: SBO:0000176
kinetic law: MODEL1310110046#
is described by: ECO:0000134
reversible: false
type: Reaction

metaR r1144
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
modifier: MODEL1310110046#
product: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.18.6.3

http://identifiers.org/biomodels.db/MODEL1310110046#_e8cea949_5345_48ba_9cf9_1cee87acd6ae
has only substance units: false
is encoded by: hsa:1345
name: COX6C
is: P09669
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR NDP3ex
name: nucleoside-diphosphatase (GDP), extracellular
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_d6133a0d_f05c_4891_90e2_bdf696073b3c
boundary condition: true
type: Species
is encoded by: hsa:8527
has only substance units: false
is: SBO:0000252
name: DGKD
is: Q16760
constant: false
initial amount: NaN
initial concentration: NaN

metaR EICOSTETCPT1
kinetic law: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_d29ac6af_1064_424b_83f1_188a4cf8e07d
type: Species
is encoded by: hsa:9023
is: SBO:0000252
has only substance units: false
is: O95992
constant: false
boundary condition: true
name: CH25H
initial amount: NaN
initial concentration: NaN

metaR SGPL12r
name: Sphingosine-1-phosphate lyase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reversible: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000304
reactant: MODEL1310110046#

metaM methf m
has only substance units: false
constant: false
is: HMDB01354
name: (6R)-5,10-methenyltetrahydrofolate
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57455
boundary condition: false
initial concentration: 1.0

metaM ksi pre10 g
is: SBO:0000247
constant: false
is: C00130
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 10
initial amount: NaN
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_022ab205_40b4_4c2e_820b_0604bd34493a
name: PLCB1
is: Q9NQ66
type: Species
constant: false
boundary condition: true
is encoded by: hsa:23236
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM co2 m
initial amount: NaN
boundary condition: false
is: C00011
is: CHEBI:16526
name: CO2
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01967
initial concentration: 1.0

metaM cmp m
initial amount: NaN
boundary condition: false
name: CMP(2-)
constant: false
is: CHEBI:60377
is: HMDB00095
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_f0f29ad2_f093_4f70_a17d_bcd451dbac18
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:5140
name: PDE3B
constant: false
boundary condition: true
is: SBO:0000252
is: A7E2E5
initial concentration: NaN

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaR r1723
reactant: MODEL1310110046#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#

metaM dadp c
is: C00206
is: HMDB01508
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
name: dADP
constant: false
type: Species
is: SBO:0000247
is: CHEBI:57667
initial amount: NaN

metaR GALt1r
name: galactose transport (uniport)
reactant: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
type: Reaction
reversible: true
is: SBO:0000185

metaR NTD6
kinetic law: MODEL1310110046#
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
type: Reaction
fast: false
name: 5'-nucleotidase (dAMP)
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.5

metaM arachd c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:32395
is: HMDB01043
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9cccdcd7_43e5_42fa_acdb_c3d6df9e926f
is: Q96I99
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SUCLG2
initial amount: NaN
is encoded by: hsa:8801
type: Species
constant: false
boundary condition: true

metaR HPDCAt
is: SBO:0000185
reversible: true
type: Reaction
name: fatty acid transport via diffusion
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR C161CPT2
reactant: MODEL1310110046#
reversible: false
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
modifier: MODEL1310110046#
is: SBO:0000176
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
is described by: ECO:0000000
kinetic law: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110046#_45280306_c68e_4d01_85ae_66a88c469b1a
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: P00505
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2806
name: GOT2

http://identifiers.org/biomodels.db/MODEL1310110046#_f4456b68_b0fb_493d_aa03_c984d0294abb
initial concentration: NaN
name: PLCB4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5332
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: E2QRH8

metaM cmp n
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:60377
is: HMDB00095
name: CMP(2-)
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
initial amount: NaN

metaM trp L c
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00929
constant: false
name: L-tryptophan
is: SBO:0000247
is: CHEBI:16828
initial amount: NaN

metaR PI45P4P
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
reversible: false
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000

metaM aicar e
is: HMDB01517
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: C04677

metaR r1722
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: Y+LAT2 Utilized transport

metaR CHOLtu
fast: false
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
product: MODEL1310110046#
reversible: true
name: Choline uniport
is: SBO:0000185
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_7d6589c7_098e_4ee5_b436_60a6ba3ed97a
is encoded by: hsa:686
has only substance units: false
name: BTD
type: Species
is: P43251
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaM Ser Gly Ala X Gly l
is: CHEBI:36005
constant: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB02183
initial amount: NaN
type: Species

metaM ksi pre5 g
constant: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 5
notes: FORMULA: C101H164N7O75SX CHARGE: -2
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:28067
type: Species

metaR C161CPT1
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: production of palmitoleoylcarnitine
type: Reaction
modifier: MODEL1310110046#
is: SBO:0000176
reversible: false
reactant: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_238ef40d_18a4_44c0_9ff6_4050843547c1
initial concentration: NaN
is encoded by: hsa:205
boundary condition: true
name: AK4
constant: false
has only substance units: false
type: Species
is: P27144
is: SBO:0000252
initial amount: NaN

metaM ei11ecoa x
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
name: 11-eicosenoylcoa
type: Species
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_096bbba1_88d7_44b1_908c_590fb0514841
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1375
has only substance units: false
type: Species
is: Q92523
boundary condition: true
name: CPT1B

metaR 4HBZFm
kinetic law: MODEL1310110046#
name: 4-hydroxybenzoate formation
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#

metaM hpdcacrn c
initial concentration: 1.0
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
boundary condition: false
has only substance units: false
constant: false
name: heptadecanoyl carnitine
is: SBO:0000247
initial amount: NaN
is: HMDB06210
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_01ad5adc_215a_41a5_abac_363576a4f68a
initial amount: NaN
type: Species
is encoded by: hsa:240
name: ALOX5
initial concentration: NaN
constant: false
is: P09917
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR EICOSTETCPT2
fast: false
modifier: MODEL1310110046#
name: carnitine transferase
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR r1147
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_d7a68ac8_3cee_46a7_98aa_014b2a3f45b4
constant: false
is encoded by: hsa:230
has only substance units: false
initial amount: NaN
is: P09972
is: SBO:0000252
initial concentration: NaN
type: Species
name: ALDOC
boundary condition: true

metaM arachd e
has only substance units: false
initial concentration: 1.0
is: CHEBI:32395
boundary condition: false
is: HMDB01043
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

metaR NTD8
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
modifier: MODEL1310110046#
name: 5'-nucleotidase (dGMP)
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000269

metaR NTD9
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110046#
fast: false
is: SBO:0000176
reactant: MODEL1310110046#
name: 5'-nucleotidase (GMP)
is described by: ECO:0000134
kinetic law: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
type: Reaction

metaM trp L e
is: CHEBI:16828
name: L-tryptophan
is: HMDB00929
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM dhlpro m
type: Species
is: SBO:0000247
initial amount: NaN
name: Dihydrolipolprotein
boundary condition: false
is: CHEBI:16194
has only substance units: false
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
initial concentration: 1.0
constant: false

metaM 10fthf6glu e
is: CHEBI:58190
name: 10-formyltetrahydrofolate-[Glu](6)
has only substance units: false
initial concentration: 1.0
is: HMDB00224
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110046#_018d69bc_fb32_4e2e_a53b_72b8e432ab81
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC25A22
is encoded by: hsa:79751
type: Species
boundary condition: true
is: Q9H936
initial amount: NaN

metaM aicar c
is: C04677
has only substance units: false
is: HMDB01517
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475

http://identifiers.org/biomodels.db/MODEL1310110046#_a02778e1_82c4_4ffd_a461_c043c978cd40
initial amount: NaN
is: P08195
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC3A2
is encoded by: hsa:6520
type: Species
is: SBO:0000252

metaR r1148
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110046#
name: Active transport
fast: false
kinetic law: MODEL1310110046#

metaM octe5coa m
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: 5-octenoylcoa
initial concentration: 1.0
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

metaR NTD1
kinetic law: MODEL1310110046#
fast: false
reversible: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dUMP)
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110046#
type: Reaction

metaR RE1518M
kinetic law: MODEL1310110046#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000176
name: RE1518
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_2665da1f_2a24_423b_96e5_6b456fe01b60
name: PLA2G2F
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:64600
has only substance units: false
boundary condition: true
is: Q9BZM2
is: SBO:0000252

metaR RPE
name: ribulose 5-phosphate 3-epimerase
fast: false
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/5.1.3.1
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110046#
reversible: true

metaM ksii core4 pre4 g
initial amount: NaN
is: CHEBI:58053
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: C00130
name: keratan sulfate II biosynthesis, precursor 4
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110046#_aa6f387d_aaff_440f_bf45_73cb344e2d93
has only substance units: false
name: ATP5J2
initial concentration: NaN
constant: false
is encoded by: hsa:9551
type: Species
boundary condition: true
initial amount: NaN
is: F8W7V3
is: SBO:0000252

metaM oh1 c
notes: FORMULA: HO CHARGE: -1
boundary condition: false
is: C01328
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: hydroxide ion
is: SBO:0000247
constant: false
type: Species
is: HMDB01039

http://identifiers.org/biomodels.db/MODEL1310110046#_4afb03eb_0519_4192_ba1a_9d64ac1cff8e
initial amount: NaN
is: D9HTE9
name: SLC25A1
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6576
is: SBO:0000252
constant: false

metaR NAt5
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES:NCD
name: sodium/ammonium proton antiporter
reactant: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
is: SBO:0000185
fast: false
type: Reaction

metaM 5HPET c
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57450
is: HMDB01193
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
boundary condition: false
constant: false
name: 5(S)-HPETE(1-)

metaM naglc2p L c
has only substance units: false
is: CHEBI:18278
type: Species
initial concentration: 1.0
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaM but e
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
is: CHEBI:17968
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00039

http://identifiers.org/biomodels.db/MODEL1310110046#_2ac5a07b_f68d_4ca8_b7fc_fc9091a3e348
is encoded by: hsa:1962
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: Q9NY65
initial amount: NaN
name: EHHADH
type: Species

metaR GLCt1r
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
reactant: MODEL1310110046#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
name: glucose transport (uniport)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_aa1bf600_e57c_4b23_bd53_91ee0f792034
is: SBO:0000297
is encoded by: hsa:5160
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
has part: P08559
name: DLAT:DLD:PDHA1:PDHB:PDHX

metaR APOC LYS BTNPm
name: proteolysis of apoC-Lys-btn, mitochondrial
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110046#

metaM pdx5p c
constant: false
is: HMDB01319
type: Species
name: Pyridoxine 5'-phosphate
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
is: CHEBI:58589
initial amount: NaN
has only substance units: false
is: C00627
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_72b0d304_35c8_449d_8e92_8865701b18ce
is: P07205
is encoded by: hsa:5232
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: PGK2
constant: false

metaM ksi pre24 g
type: Species
name: keratan sulfate I biosynthesis, precursor 24
is: CHEBI:58053
boundary condition: false
initial concentration: 1.0
is: C00130
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
has only substance units: false
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110046#_96580ffe_1fcc_45ee_b5e9_cb39398bc143
boundary condition: true
constant: false
is encoded by: hsa:114
name: ADCY8
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q4F7X0
type: Species

metaM hs deg16 l
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: SBO:0000247
constant: false
type: Species
name: heparan sulfate, degradation product 16
has only substance units: false
initial amount: NaN
is: HMDB02704
is: CHEBI:21338

metaR FRDPtcr
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum

metaR FUMSO3tm
is described by: ECO:0000269
reactant: MODEL1310110046#
reversible: true
name: Fumarate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110046#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
product: MODEL1310110046#
modifier: MODEL1310110046#

metaR GLYCtm
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
name: glycerol transport
fast: false
product: MODEL1310110046#
reversible: true

metaM co2 r
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00011
name: CO2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_95705a7c_170c_433c_9bd1_c4b335517d72
is: O14734
type: Species
name: ACOT8
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10005
constant: false
has only substance units: false
initial amount: NaN

metaM sphs1p r
constant: false
is: HMDB00277
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_00b39f44_92e8_4221_9ca1_24f0c1a7be1b
name: ST3GAL4
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: Q6IBE6
is encoded by: hsa:6484
initial amount: NaN
is: SBO:0000252
constant: false

metaM octdececoa c
name: octadecenoylcoa
is: HMDB06351
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR NTD3
fast: false
reactant: MODEL1310110046#
name: 5'-nucleotidase (dCMP)
kinetic law: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
product: MODEL1310110046#

metaM HC02216 e
has only substance units: false
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: prostaglandin-f2beta
is: CHEBI:28922

metaM duri e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: Deoxyuridine
constant: false
is: HMDB00012
type: Species
is: C00526
is: SBO:0000247
boundary condition: false
is: CHEBI:16450
has only substance units: false

metaM HC01403 m
has only substance units: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: SBO:0000247
name: (S)-Hydroxydecanoyl-CoA
boundary condition: false
initial amount: NaN
is: CHEBI:28325
type: Species
initial concentration: 1.0
constant: false

metaR 3HBCOAHLm
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM

metaR ARACHCRNt
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
fast: false
name: transport into the mitochondria (carnitine)
reversible: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR r1423
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110046#
name: Facilitated diffusion
reversible: false
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_fe73157f_897f_45f0_b69f_c58443498100
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: IDH1
is encoded by: hsa:3417
initial amount: NaN
is: O75874

metaM oh1 e
boundary condition: false
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: hydroxide ion
is: HMDB01039
type: Species
is: C01328

metaR DGK1
fast: false
is described by: ECO:0000269
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: deoxyguanylate kinase (dGMP:ATP)
type: Reaction
reactant: MODEL1310110046#
reversible: true

metaR KSII CORE2t
is: SBO:0000185
name: keratan sulfate II (core2) transport, golgi to extracellular
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110046#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
name: butyrate
initial concentration: 1.0
is: CHEBI:17968
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00039

metaR CSNAT2m
kinetic law: MODEL1310110046#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
name: carnitine O-aceyltransferase, mitochondrial
product: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_c094d6f2_e800_44e7_a1e1_7dd9c93fdb72
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P36551
has only substance units: false
name: CPOX
is encoded by: hsa:1371
constant: false

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaM dece4coa m
is: HMDB02145
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: 4-decenoylcoa
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM 3dphb m
is: HMDB06251
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 3-Decaprenyl-4-hydroxybenzoate
type: Species
has only substance units: false

metaR SEBCOACROT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_22bc014c_f05a_4fdb_9af6_60d2a8782d45
is: SBO:0000252
is encoded by: hsa:4701
constant: false
initial concentration: NaN
is: Q6FG42
boundary condition: true
has only substance units: false
initial amount: NaN
name: NDUFA7
type: Species

metaM ksii core2 pre6 g
type: Species
notes: FORMULA: C61H98N5O46SX CHARGE: -2
boundary condition: false
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 6
constant: false
initial concentration: 1.0

metaM 2hexdtricoa x
type: Species
name: 2,7,10-hexadecatrienoylcoa
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaM dlnlcgcoa c
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaM pristcoa c
has only substance units: false
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial concentration: 1.0
name: pristanoyl coa
type: Species
boundary condition: false
constant: false
is: CHEBI:51341
is: SBO:0000247

metaM co2 e
has only substance units: false
type: Species
is: C00011
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
initial amount: NaN
name: CO2
is: CHEBI:16526
constant: false
boundary condition: false
is: SBO:0000247

metaM cmp e
has only substance units: false
type: Species
is: HMDB00095
is: CHEBI:60377
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
boundary condition: false
is: SBO:0000247
name: CMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110046#_6012c7fb_cc06_479f_98bb_1c53dc00de0e
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4535
boundary condition: true
is: Q85KV6
name: ND1
type: Species
is: SBO:0000252

metaR r2509
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110046#_5facf380_c013_4831_81da_d3220adbad52
is encoded by: hsa:AI934540
name: _AI934540_1_c
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

W3 CDTF: Fri Aug 31 01:59:16 BST 2012

metaR r1429
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Free diffusion
product: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#

metaR GGH 7THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
fast: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110046#

metaR r1610
reactant: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM leuktrA4 c
name: leukotriene A4(1-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
is: HMDB01337
initial concentration: 1.0
type: Species

metaM zymstnl r
is: SBO:0000247
boundary condition: false
is: HMDB06841
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: 5alpha-cholest-8-en-3beta-ol
is: CHEBI:16608
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845

metaM HC01602 c
has only substance units: false
name: 10-Formyltetrahydrofolate
boundary condition: false
is: C00234
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
constant: false
initial amount: NaN
type: Species

metaR S6T10g
fast: false
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110046#
is described by: ECO:0000000

metaM HC02216 c
is: CHEBI:28922
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: prostaglandin-f2beta

http://identifiers.org/biomodels.db/MODEL1310110046#_85eb168e_0009_4012_8e55_65ba840b6077
boundary condition: true
name: ACP1
initial concentration: NaN
constant: false
is: P24666
has only substance units: false
initial amount: NaN
is encoded by: hsa:52
type: Species
is: SBO:0000252

metaR r0638
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.2
reversible: true
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110046#_96006b87_d404_4379_b2d5_c418da26fc06
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PIGP
initial concentration: NaN
constant: false
type: Species
is: P57054
is encoded by: hsa:51227
boundary condition: true

metaM ksi deg19 l
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00812
is: CHEBI:16953
boundary condition: false
name: keratan sulfate I, degradation product 19
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
constant: false
initial amount: NaN
has only substance units: false

metaR r2508
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
fast: false
name: Utilized transport
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaR H2CO3D
name: carboxylic acid dissociation
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
reversible: true
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.1
fast: false

W3 CDTF: Fri Aug 31 01:59:16 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110046#_d9ad4275_aaf3_470d_be09_61c232a8c7ba
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI620219
is: SBO:0000252
has only substance units: false
name: _AI620219_1_e
initial amount: NaN
constant: false
type: Species

metaR VACCCPT2
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: carnitine transferase
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_6906da43_db3d_40e5_b774_6b3fe40a7398
is encoded by: hsa:10201
is: SBO:0000252
boundary condition: true
name: NME6
initial amount: NaN
initial concentration: NaN
is: O75414
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_a178439f_39d2_458e_acc5_3e2e250f15a9
is encoded by: hsa:84812
boundary condition: true
initial amount: NaN
name: PLCD4
constant: false
is: Q9BRC7
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_27dec70f_a180_4c43_9172_0020bb743c5e
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:3990
is: A6H8L5
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: LIPC

http://identifiers.org/biomodels.db/MODEL1310110046#_dbf8ef4f_80e7_4e6f_8f27_9224415c27ba
is encoded by: hsa:1581
is: SBO:0000252
type: Species
is: P22680
constant: false
initial concentration: NaN
name: CYP7A1
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_27c5e894_f158_4a7b_b73d_36feadf5b054
constant: false
initial amount: NaN
is encoded by: hsa:9152
initial concentration: NaN
boundary condition: true
name: SLC6A5
type: Species
is: Q9Y345
has only substance units: false
is: SBO:0000252

metaM vacc e
is: SBO:0000247
name: trans-vaccenate
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaR CHOLtn
type: Reaction
is: SBO:0000185
product: MODEL1310110046#
name: Choline transport, nuclear through pores
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it

metaR PVD3
is described by: ECO:0000134
name: Previtamin D3 formation
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
product: MODEL1310110046#
reversible: true

metaR r0639
reversible: false
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110046#

metaR r1612
fast: false
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
reversible: true
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_83fdba82_37a8_481f_b193_c8e5e507f419
is: O95168
is: SBO:0000252
constant: false
name: NDUFB4
has only substance units: false
type: Species
is encoded by: hsa:4710
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR VACCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: carnitine O-palmitoyltransferase
fast: false
modifier: MODEL1310110046#
product: MODEL1310110046#

metaM leuktrA4 e
initial concentration: 1.0
is: CHEBI:57463
type: Species
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
boundary condition: false
initial amount: NaN
is: HMDB01337
is: SBO:0000247
name: leukotriene A4(1-)
constant: false

W3 CDTF: Fri Aug 31 01:59:15 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110046#_47a688d1_f09d_4b32_98dc_9da954c51d5c
initial amount: NaN
type: Species
name: GBA
has only substance units: false
is encoded by: hsa:2629
boundary condition: true
initial concentration: NaN
is: B7Z6S9
constant: false
is: SBO:0000252

metaM adrn c
initial amount: NaN
is: SBO:0000247
name: adrenic acid
initial concentration: 1.0
is: HMDB02226
is: CHEBI:53487
boundary condition: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_87c5b0ff_6380_4380_af29_64ba61f13f93
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:501
is: SBO:0000252
is: E7EPT3
name: ALDH7A1

http://identifiers.org/biomodels.db/MODEL1310110046#_7c70e337_4fc3_4b3e_9a02_abea7af9643d
type: Species
boundary condition: true
has only substance units: false
name: AICDA
is encoded by: hsa:57379
is: SBO:0000252
is: Q546Y9
initial amount: NaN
initial concentration: NaN
constant: false

metaR 5MTAte
type: Reaction
name: Transport of 5-S-methyl-5-thioadenosine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true

metaM Rtotal2coa c
constant: false
has only substance units: false
is: HMDB00294
name: R total 2 coenzyme A
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16199
boundary condition: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
type: Species
is: C00086

http://identifiers.org/biomodels.db/MODEL1310110046#_66304dcd_0860_4604_ad08_8ad7916685e0
initial concentration: NaN
type: Species
initial amount: NaN
is: P17568
constant: false
name: NDUFB7
is encoded by: hsa:4713
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR RTOTAL2t
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport
fast: false
is: SBO:0000185

metaR S6TASE9ly
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
name: N-acetylgalactosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM thm c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Thiamin
notes: FORMULA: C12H17N4OS CHARGE: 1
is: HMDB00235
type: Species
has only substance units: false
is: C00378
is: CHEBI:0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_44f2d812_4519_4fe3_9715_54cd2f9dcd55
name: GART
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2618
is: P22102
constant: false
initial amount: NaN
type: Species

metaR r1611
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_88bc4c27_9006_4516_a000_060b659c3f63
type: Species
has only substance units: false
constant: false
is: Q9BWD1
name: ACAT2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:39
is: SBO:0000252
initial amount: NaN

metaR r1428
kinetic law: MODEL1310110046#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
name: Free diffusion
reactant: MODEL1310110046#
fast: false

W3 CDTF: Fri Aug 31 01:59:15 BST 2012

metaR C10DCe
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of sebacoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_1fec0bd4_a0ba_457c_905f_59df16505687
initial amount: NaN
has only substance units: false
name: SDR16C5
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:195814
initial concentration: NaN
is: B3KT84

http://identifiers.org/biomodels.db/MODEL1310110046#_5a586159_b534_416b_aa66_72f2cb9254f9
has only substance units: false
type: Species
is: B3KT19
name: PIK3R1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5295
constant: false
is: SBO:0000252

metaM cmp c
is: HMDB00095
type: Species
is: C00055
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
name: CMP
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaM co2 c
is: C00011
type: Species
is: CHEBI:3313
initial amount: NaN
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0
initial concentration: 1.0
name: CO2
is: HMDB01967
is: SBO:0000247
has only substance units: false
constant: false

metaR GLCAASE8ly
reactant: MODEL1310110046#
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110046#
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_791d028d_8e5d_4ba3_8947_eeaa33efbef0
is encoded by: hsa:4842
initial concentration: NaN
boundary condition: true
name: NOS1
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: B4DG68
type: Species

metaR NACHEXA10ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110046#
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110046#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_f12fefc3_73ce_4785_af1e_cab2b89fcdbf
is encoded by: hsa:514
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
constant: false
initial amount: NaN
is encoded by: hsa:513
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false

metaR LNELDCCPT1
is described by: ECO:0000269
fast: false
product: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false

metaM 35cgmp c
name: 3',5'-cyclic GMP(1-)
type: Species
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01314
boundary condition: false
is: CHEBI:57746
has only substance units: false

metaR r1578
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
fast: false
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185

metaR r1614
reversible: true
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#

metaR CSNAT2x
type: Reaction
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
kinetic law: MODEL1310110046#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.137
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ

metaR DUMPtn
is described by: ECO:0000000
reversible: true
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
fast: false
kinetic law: MODEL1310110046#

metaM thbpt4acam c
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
type: Species
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
is: CHEBI:15374
initial concentration: 1.0
is: HMDB02281
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_e43eee5a_6296_44f6_a620_94b688001e54
is: D9HTE9
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6576
type: Species
boundary condition: true
initial concentration: NaN
name: SLC25A1

metaR FAOXC163C164x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR C161CRN2t
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
type: Reaction
reversible: false
reactant: MODEL1310110046#
name: C161 transport into the mitochondria
is described by: ECO:0000269
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaM xol7ah2 m
name: 5beta-cholestane-3alpha,7alpha-diol
is: SBO:0000247
is: CHEBI:28047
type: Species
initial amount: NaN
is: HMDB06893
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452

http://identifiers.org/biomodels.db/MODEL1310110046#_be4c98fe_8af8_4f70_b47c_f319cd8444b3
is encoded by: hsa:4716
is: SBO:0000252
initial concentration: NaN
is: A8K761
name: NDUFB10
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM adrn e
has only substance units: false
is: SBO:0000247
name: adrenic acid
is: CHEBI:53487
is: HMDB02226
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
boundary condition: false

metaR CEPTE
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110046#
type: Reaction
name: ethanolamine phosphotransferase
is version of: http://identifiers.org/ec-code/2.7.8.2
reversible: false
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110046#

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR r1613
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1579
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_242d67ac_8baf_4488_8fb1_50c6d4d2e69e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51102
is: Q9BV79
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: MECR

metaR FAOXC103C102m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR CHOLtr
reversible: true
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110046#
name: choline intracellular transport
fast: false
type: Reaction

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR ITCOALm
reactant: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110046#
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
type: Reaction
name: Itaconate--CoA ligase (ADP-forming), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110046#_29bf0d45_56f5_4247_9f62_416fbfe66f6e
type: Species
constant: false
name: ADA
initial concentration: NaN
is: P00813
is encoded by: hsa:100
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_489e1d8f_acf0_4053_82ed_8df631119e0a
has only substance units: false
initial amount: NaN
is encoded by: hsa:29922
constant: false
boundary condition: true
type: Species
name: NME7
initial concentration: NaN
is: SBO:0000252

metaM methf c
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
constant: false
initial concentration: 1.0
is: C00445
is: HMDB01354
initial amount: NaN
boundary condition: false
name: 5,10-Methenyltetrahydrofolate
has only substance units: false
is: CHEBI:57455
type: Species

metaR r1616
modifier: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_b8c31c79_bf70_4fd3_9cd9_45e0970a6b4c
is encoded by: hsa:38
is: SBO:0000252
boundary condition: true
constant: false
is: P24752
name: ACAT1
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM octe5coa x
name: 5-octenoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

metaR r2507
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
kinetic law: MODEL1310110046#
name: Utilized transport
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b7f0d5aa_06f2_4d41_91d1_3db0d1c7a98f
constant: false
is: SBO:0000252
name: NDUFS5
boundary condition: true
is encoded by: hsa:4725
type: Species
initial concentration: NaN
is: Q6IBA0
initial amount: NaN
has only substance units: false

metaM duri n
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16450
name: 2'-deoxyuridine
type: Species
is: HMDB00012
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaM pcreat m
has only substance units: false
constant: false
initial concentration: 1.0
name: N-phosphocreatinate(2-)
is: HMDB01511
boundary condition: false
is: CHEBI:58092
is: SBO:0000247
notes: FORMULA: C4H9N3O5P CHARGE: -1 INCHI: InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)/p-2 EHMN_ABBREVIATION: C02305
initial amount: NaN
type: Species

metaM cmp g
boundary condition: false
is: CHEBI:60377
name: CMP(2-)
initial amount: NaN
has only substance units: false
is: HMDB00095
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_31dc174a_02c1_41e9_ac32_47507e71fc6c
is: Q06830
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: PRDX1
boundary condition: true
is encoded by: hsa:5052
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_2bcd3188_3b64_43c2_95b7_1a20f4c1d70f
is: SBO:0000252
type: Species
is: O15382
has only substance units: false
is encoded by: hsa:587
initial amount: NaN
initial concentration: NaN
constant: false
name: BCAT2
boundary condition: true

metaM acac m
boundary condition: false
has only substance units: false
is: HMDB00060
initial amount: NaN
name: acetoacetate
constant: false
is: CHEBI:13705
type: Species
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247

metaR PRODt2r
fast: false
product: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
is: SBO:0000185
reactant: MODEL1310110046#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: D-proline reversible transport via proton symport

metaR PPNCL3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.5
reactant: MODEL1310110046#
type: Reaction
fast: false
product: MODEL1310110046#
name: phosphopantothenate-cysteine ligase
modifier: MODEL1310110046#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110046#

metaR r1576
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
reversible: true
type: Reaction

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_ef7abdfc_93d2_4b1c_899e_3db1b549807a
is encoded by: hsa:223
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: P49189
name: ALDH9A1

metaR r1615
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2506
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
name: Utilized transport
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185

metaM glcur l
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
boundary condition: false
name: D-glucuronate
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00127
type: Species

metaR LNELDCCPT2
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110046#

metaR r0226
reactant: MODEL1310110046#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
modifier: MODEL1310110046#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaM ppbng c
has only substance units: false
initial concentration: 1.0
name: Porphobilinogen
is: CHEBI:58126
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
initial amount: NaN
type: Species
is: C00931
is: HMDB00245

metaM vacc c
name: trans-vaccenate
is: SBO:0000247
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: C08367
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:30828
initial amount: NaN

metaR r1143
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
type: Reaction
reversible: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185

metaR LCYSTAT
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
product: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
name: L-Cysteate:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110046#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_c8a5bcfa_acaf_4b45_a2c6_397d4f053515
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:27068
is: SBO:0000252
initial concentration: NaN
is: F8WDN9
has only substance units: false
boundary condition: true
name: PPA2

http://identifiers.org/biomodels.db/MODEL1310110046#_2333c4a6_0e10_458a_b7f6_b40b0ab124b6
is: SBO:0000252
is: Q9UKM7
is encoded by: hsa:11253
type: Species
name: MAN1B1
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f343c2f2_e8b5_40bb_a5b6_573044a4936d
is: P30084
is: SBO:0000252
is encoded by: hsa:1892
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: ECHS1
constant: false
has only substance units: false

metaM ptdcacrn c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: pendtadenoyl carnitine
type: Species
is: CHEBI:15811
constant: false
has only substance units: false
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: HMDB01721

metaM m5masnB2 g
notes: FORMULA: C52H87N2O40X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: HMDB06814
is: CHEBI:58401
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false

metaM T antigen g
is: SBO:0000247
notes: FORMULA: C14H24NO10X CHARGE: 0
name: T antigen (core 1)
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:22783
boundary condition: false
constant: false

metaR S6TASE24ly
kinetic law: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110046#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR SUCCt2m
modifier: MODEL1310110046#
product: MODEL1310110046#
name: succinate transport, mitochondrial
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_84902862_9419_4407_837f_0061b3a13533
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:27068
is: Q9H2U2
initial concentration: NaN
name: PPA2
type: Species
constant: false
is: SBO:0000252

metaR r1573
reactant: MODEL1310110046#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR GLNS
fast: false
is described by: ECO:0000254
reversible: false
is: SBO:0000176
name: glutamine synthetase
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.1.1.15

metaR r0666
fast: false
type: Reaction
modifier: MODEL1310110046#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
is described by: ECO:0000000

metaM ksi pre35 g
name: keratan sulfate I biosynthesis, precursor 35
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:28067
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C241H384N17O205S11X CHARGE: -12

metaM 3dhguln c
has only substance units: false
initial concentration: 1.0
name: 3-dehydro-L-gulonate
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57655
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
boundary condition: false

metaR r0644
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false

metaM cspg b e
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00630
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16040
constant: false

metaM CE5132 c
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110046#_f439d4e5_ed59_4193_bef6_6f7bdc5c8da9
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: SDHA
type: Species
is encoded by: hsa:6389
has only substance units: false
is: P31040

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.36
is: SBO:0000176
kinetic law: MODEL1310110046#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
reactant: MODEL1310110046#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
product: MODEL1310110046#
modifier: MODEL1310110046#

metaM gal l
has only substance units: false
is: CHEBI:12936
type: Species
initial concentration: 1.0
is: HMDB00143
boundary condition: false
name: D-galactose
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial amount: NaN

metaR ME2m
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.40
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.38
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
name: malic enzyme (NADP), mitochondrial

metaR DMNONCRNCPT2
type: Reaction
fast: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: DMNONCRNCPT2
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
product: MODEL1310110046#

metaM ksii core4 deg4 l
name: keratan sulfate II (core 4-linked), degradation product 4
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:16953
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C66H108N6O48SX CHARGE: -1
is: HMDB00812

http://identifiers.org/biomodels.db/MODEL1310110046#_74f88da4_4212_489f_a909_27bb57bdee83
is encoded by: hsa:51703
is: Q9ULC5
name: ACSL5
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r0643
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000

metaR r0642
is: SBO:0000176
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110046#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR AG13T8g
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#

metaM udpg r
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN
constant: false
type: Species
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
has only substance units: false
is: HMDB00286
is: CHEBI:58367
is: SBO:0000247

metaM ru5p D c
has only substance units: false
constant: false
is: HMDB00618
is: SBO:0000247
is: CHEBI:58121
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial amount: NaN
name: D-ribulose 5-phosphate(2-)

metaR r0170
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false

metaR r1575
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
fast: false
reversible: true
is described by: ECO:0000000

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM sphs1p e
is: HMDB00277
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r0668
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.19
reactant: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43

metaR FE2tm
reversible: false
type: Reaction
fast: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
name: iron (II) transport
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_05ea5e69_fd22_46c2_8524_38e0022792f6
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:81579
has only substance units: false
boundary condition: true
type: Species
is: Q542Y6
initial amount: NaN
name: PLA2G12A

metaR r1629
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_405b8f41_f483_4119_a02f_3bb642fc7dba
is encoded by: hsa:H53099
type: Species
name: _H53099_1_m
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM n2m2nmasn e
initial concentration: 1.0
notes: FORMULA: C58H96N5O40X CHARGE: 0
has only substance units: false
constant: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
is: C04946
type: Species
boundary condition: false
is: SBO:0000247

metaM od2coa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
boundary condition: false
name: trans-Octadec-2-enoyl-CoA
constant: false
initial concentration: 1.0
has only substance units: false
is: C16218
is: SBO:0000247
is: CHEBI:50570
initial amount: NaN
type: Species
is: HMDB06529

http://identifiers.org/biomodels.db/MODEL1310110046#_732b2b73_f651_43d0_af90_1f8ddb5954af
boundary condition: true
constant: false
has only substance units: false
name: GPX5
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: O75715
is encoded by: hsa:2880

metaR PDE4n
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
product: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
is: SBO:0000176
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
reversible: false
type: Reaction

metaM co e
name: carbon monoxide
is: CHEBI:17245
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01361
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_8aed3cac_22ea_42b1_9748_4046b5cdbbb7
boundary condition: true
constant: false
is encoded by: hsa:1384
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: CRAT

metaR r0641
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reversible: true
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#

metaR AIRCr
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
name: phosphoribosylaminoimidazole carboxylase
is version of: http://identifiers.org/ec-code/6.3.2.6
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
is: SBO:0000176

metaR PROt4 2 r
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
type: Reaction
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Proline transport (sodium symport) (2:1)
is described by: ECO:0000006
reversible: true
reactant: MODEL1310110046#

metaM hs deg7 l
initial amount: NaN
is: HMDB01352
type: Species
boundary condition: false
name: heparan sulfate, degradation product 7
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
is: CHEBI:17180
constant: false
has only substance units: false

metaM sl L e
boundary condition: false
is: CHEBI:61289
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
name: (S)-3-sulfonatolactate(2-)
initial amount: NaN

metaR r1574
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_72439441_e360_434a_95d8_afea2d7b9547
is encoded by: hsa:5295
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PIK3R1
is: P27986
constant: false

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_16aa3b6c_6398_4fd8_a87b_8a2749a1952e
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P60891
name: PRPS1
constant: false
initial concentration: NaN
is encoded by: hsa:5631
boundary condition: true

metaM clpndcoa x
type: Species
is: C16166
is: HMDB06267
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205476
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
is: SBO:0000247
name: clupanodonyl CoA

metaM sphs1p c
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
is: HMDB00277
is: CHEBI:60119
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_e575f982_a2f8_4e0a_b46a_2034b9a4415f
name: TXNRD1
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:7296
is: SBO:0000252

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM dd2coa x
boundary condition: false
initial amount: NaN
is: CHEBI:57330
is: SBO:0000247
is: HMDB03712
has only substance units: false
name: trans-Dodec-2-enoyl-CoA
type: Species
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7f33be7b_a9cf_499f_a5a4_3c7cf3f44c84
is encoded by: hsa:8560
type: Species
name: DEGS1
boundary condition: true
is: O15121
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_9adeb150_74ba_46f5_8478_23c0978a962b
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: COX7B2
is: Q8TF08
boundary condition: true
is encoded by: hsa:170712
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_324b6b2c_bbbb_42c6_ab2b_9ae89b051436
is encoded by: hsa:291
name: SLC25A4
has only substance units: false
is: P12235
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaR CTPtn
kinetic law: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reversible: true
product: MODEL1310110046#
fast: false
is: SBO:0000185
reactant: MODEL1310110046#
name: CTP diffusion in nucleus

metaM dectricoa x
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 2,4,7-decatrienoylcoa
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110046#_37aeff97_f4e8_4cb9_8c6c_b1b99080b1a1
type: Species
initial amount: NaN
has only substance units: false
is: Q96CA6
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:30
name: ACAA1
constant: false

metaM acac e
is: HMDB00060
is: CHEBI:13705
initial concentration: 1.0
type: Species
name: acetoacetate
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
is: SBO:0000247

metaM clpn hs c
boundary condition: false
name: clpn_hs[c]
is: HMDB02704
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: CHARGE: 0
is: CHEBI:21338
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_64d38e22_5455_4714_a0e1_f84ad4f69b56
initial amount: NaN
boundary condition: true
is: Q99808
name: SLC29A1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2030
constant: false
type: Species
is: SBO:0000252

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM dcamp c
is: CHEBI:57567
constant: false
name: N6-(1,2-Dicarboxyethyl)-AMP
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: HMDB00536
boundary condition: false
is: C03794

metaR It
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110046#
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
name: Iodide uniport
is: SBO:0000185
product: MODEL1310110046#
reactant: MODEL1310110046#

metaR r0647
is: SBO:0000176
name: Spontaneous reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
type: Reaction

metaR RE1342C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
name: RE1342
type: Reaction
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
is: SBO:0000176

metaR MI134PP
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.57
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
type: Reaction
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 1-phosphatase
reactant: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
reversible: false

metaR r2080
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110046#

metaR r0669
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reactant: MODEL1310110046#
reversible: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110046#_c31f9373_d8d6_450b_aa98_aea3fcf09fe8
name: SDHC
initial amount: NaN
is encoded by: hsa:6391
initial concentration: NaN
constant: false
boundary condition: true
is: Q99643
is: SBO:0000252
has only substance units: false
type: Species

metaR r1571
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_566e9175_e029_4a0e_8eb0_9861b9738f5b
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:8310
boundary condition: true
initial concentration: NaN
constant: false
name: ACOX3
initial amount: NaN
is: O15254

http://identifiers.org/biomodels.db/MODEL1310110046#_59e1e03b_705b_4b48_afa8_1740cfdbe361
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: PDHA2
is: P29803
is encoded by: hsa:5161
constant: false
is: SBO:0000252

metaR RE2625M
product: MODEL1310110046#
type: Reaction
name: RE2625
reactant: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_467bb55d_b024_455f_952f_eeb072034b8e
type: Species
name: ACO1
constant: false
is: P21399
is encoded by: hsa:48
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_3be81603_c053_4869_94e7_8dbac04e8f32
initial concentration: NaN
boundary condition: true
name: CA3
is: P07451
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:761

http://identifiers.org/biomodels.db/MODEL1310110046#_0b2b221d_7e6f_415c_9e73_f61e3690b857
initial concentration: NaN
boundary condition: true
name: RPIA
initial amount: NaN
has only substance units: false
is encoded by: hsa:22934
is: SBO:0000252
type: Species
is: P49247
constant: false

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR SIAASE4ly
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110046#
fast: false
name: sialidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110046#
is: SBO:0000176
type: Reaction

metaM hpdcacrn m
is: HMDB06210
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: heptadecanoyl carnitine
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaR AMY1e
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110046#
fast: false
product: MODEL1310110046#
name: alpha-amylase, extracellular (strch1 -> strch2)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110046#

metaR FAOXC24C22x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

metaR LEUKTRD4t
name: leukotriene D4 transport
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#

metaR r2081
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5dcde491_4960_4a56_b062_d97148c6562e
initial amount: NaN
is: Q9Y259
type: Species
constant: false
name: CHKB
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:1120
initial concentration: NaN

metaR FAOXC225C204m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR r1570
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false

metaM acac c
is: HMDB00060
initial concentration: 1.0
name: acetoacetate
is: CHEBI:13705
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR SRTNtu
reversible: true
modifier: MODEL1310110046#
name: Serotonin uniport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_37f9a983_5925_44dc_9460_04196e2895c8
is: P11166
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:6513
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC2A1

metaR CYTK6n
modifier: MODEL1310110046#
reversible: true
product: MODEL1310110046#
name: cytidylate kinase (CMP,CTP),nuclear
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false

metaR r2082
reversible: true
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
fast: false

metaM gt3 hs g
is: CHEBI:28424
is: SBO:0000247
has only substance units: false
name: GT3
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110046#_2bcdeb0e_2223_4ef8_b837_156ec860c554
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3631
has only substance units: false
boundary condition: true
name: INPP4A
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_f739c9b1_84cd_4e5f_b22b_a23cc6ac02d1
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:8836
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: GGH
is: Q92820

http://identifiers.org/biomodels.db/MODEL1310110046#_555e515f_1712_46e5_aef5_7cf6739349e9
has only substance units: false
initial amount: NaN
constant: false
name: SULT1A3
is: P50224
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6818

metaM 2dr5p c
has only substance units: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: CHEBI:57651
is: HMDB01031
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species
initial amount: NaN

metaR HISTAtu
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110046#
name: Histamine uniport
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_049f668c_522d_444e_b405_4e5d90ccc759
initial amount: NaN
name: DPM1
initial concentration: NaN
is: SBO:0000252
constant: false
is: O60762
boundary condition: true
type: Species
is encoded by: hsa:8813
has only substance units: false

metaM pristcoa x
is: CHEBI:51341
is: SBO:0000247
initial amount: NaN
type: Species
name: pristanoyl coa
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2

http://identifiers.org/biomodels.db/MODEL1310110046#_d80d81b4_4c57_427b_a266_db88ee16c9d0
initial amount: NaN
constant: false
is encoded by: hsa:2984
type: Species
has only substance units: false
name: GUCY2C
boundary condition: true
is: SBO:0000252
is: P25092
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_7b6949fc_b64a_432c_af90_babfde901a8c
has only substance units: false
initial concentration: NaN
name: CPT1A
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:1374
boundary condition: true
is: Q8WZ48

http://identifiers.org/biomodels.db/MODEL1310110046#_e4d35edd_192d_4265_ad5e_50037bdb023a
initial amount: NaN
name: ATP1A1
initial concentration: NaN
is: SBO:0000252
constant: false
is: B7Z3U6
is encoded by: hsa:476
type: Species
boundary condition: true
has only substance units: false

metaM dadp n
is: HMDB01508
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: dADP(3-)

metaR r2083
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_43a5ec19_5fdf_4488_97f7_009aacab58df
name: PDE9A
is encoded by: hsa:5152
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR GALASE18ly
name: beta-galactosidase, lysosomal
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110046#
is described by: ECO:0000000

metaM nrvnc e
initial concentration: 1.0
is: CHEBI:32392
type: Species
constant: false
is: HMDB02368
is: SBO:0000247
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
boundary condition: false
has only substance units: false
initial amount: NaN
name: nervonate

metaR LINKDEG2ly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
name: degradation of proteoglycan linkage region, lysosomal

metaR FAOXC102C101x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_022810b1_54d7_4d56_8450_99a9714e46e8
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC23A2
is encoded by: hsa:9962
constant: false
initial amount: NaN
has only substance units: false

metaR FAOXC103C102x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR r2084
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_cd7c75ce_3eca_4637_9af2_947364fe3639
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:1384
is: P43155
is: SBO:0000252
initial amount: NaN
type: Species
name: CRAT

metaR DCSPTN1COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
product: MODEL1310110046#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
name: fatty acid intracellular transport
reactant: MODEL1310110046#
fast: false

metaM 4hbzcoa m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: 4-hydroxybenoyl-CoA
boundary condition: false
initial amount: NaN
type: Species
is: HMDB06467
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1

metaR RE3244R
type: Reaction
is described by: ECO:0000000
name: RE3244
is: SBO:0000176
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110046#

metaM fru c
is: CHEBI:15824
is: SBO:0000247
initial concentration: 1.0
type: Species
name: D-Fructose
constant: false
is: HMDB00660
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00095

metaM dectricoa m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: 2,4,7-decatrienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_3928d757_fbb4_4fa3_bb0a_7f9916d58fe0
name: _U37519_1_c
is encoded by: hsa:U37519
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR MM7B2g
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113

metaM dudp c
name: dUDP
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01000
is: CHEBI:60471
constant: false
initial concentration: 1.0
is: C01346
boundary condition: false

metaM ocdca c
is: CHEBI:25629
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial amount: NaN
is: HMDB00827
boundary condition: false
constant: false
name: stearate
has only substance units: false
type: Species

metaM glyclt x
has only substance units: false
is: SBO:0000247
type: Species
constant: false
name: glycolate
is: CHEBI:29805
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00115
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

metaM HC01609 e
type: Species
initial amount: NaN
is: CHEBI:28766
is: SBO:0000247
boundary condition: false
name: UroporphyrinogenI
has only substance units: false
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_4b8570f5_1cd8_41f5_9bf2_b6ca8d17c079
has only substance units: false
initial concentration: NaN
constant: false
name: GAMT
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:2593

http://identifiers.org/biomodels.db/MODEL1310110046#_a8531e7c_d784_49d4_bd9c_4bce977204da
initial concentration: NaN
is encoded by: hsa:130367
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q8IWX5
has only substance units: false
initial amount: NaN
name: SGPP2

metaR FUMTSULtm
is described by: ECO:0000269
name: Fumarate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_6b024f8b_5174_4f8f_9f01_f2c8c56f39a9
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P03915
name: ND5
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4540

metaR r2085
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#

metaR r0377
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.3

metaR r0178
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_db5e0d94_3650_43dd_bf2f_7c6447230040
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:771
type: Species
initial amount: NaN
constant: false
name: CA12
is: O43570

metaM ttetddcoa m
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
name: trans5,8tetradecadienoylcoa
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaR LSTO2r
reversible: false
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110046#
type: Reaction
name: Lathosterol oxidase
is: SBO:0000176
is described by: ECO:0000269
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.21.6

http://identifiers.org/biomodels.db/MODEL1310110046#_6dc59b1b_5b9c_4f82_8e10_c00b82302419
is encoded by: hsa:LOC374569
is: SBO:0000252
initial concentration: NaN
constant: false
name: _LOC374569_1_e
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_55f863d4_bcf8_45c1_bcfb_52e822c16665
is encoded by: hsa:8693
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: GALNT4
initial concentration: NaN
has only substance units: false
type: Species
is: Q8N4A0

metaR r0660
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR RE0512M
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
name: RE0512
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR FAOXC16DCr
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR FATP8t
kinetic law: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty acid electroneutral transport
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
modifier: MODEL1310110046#
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.7
fast: false

metaM nrvnc c
is: CHEBI:32392
type: Species
is: HMDB02368
name: nervonate
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR ACNMLr
reversible: true
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
fast: false
is: SBO:0000176
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
name: N-Acetylneuraminate lyase (reversible)

metaR r2086
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM dadp m
boundary condition: false
is: CHEBI:57667
type: Species
is: HMDB01508
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: dADP(3-)

metaR r0179
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaM ocdca e
initial amount: NaN
constant: false
is: CHEBI:25629
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: HMDB00827
name: octadecanoate (n-C18:0)
is: C01530

metaM taur c
initial amount: NaN
constant: false
is: CHEBI:3544
is: SBO:0000247
is: C00245
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00251
name: Taurine

metaR DECCRNe
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaM co c
initial concentration: 1.0
is: CHEBI:17245
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
name: carbon monoxide
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01361

http://identifiers.org/biomodels.db/MODEL1310110046#_1a0afad8_f988_4cc8_86e4_50db4e7adc2e
name: FLAD1
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:80308
is: Q8NFF5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_3a0a23b4_5c90_4bac_9e06_e12e38885808
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:D29675
name: _D29675_1_e
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_23599281_3517_46b0_bbd9_c05d48d2b1ca
is encoded by: hsa:5337
initial concentration: NaN
type: Species
name: PLD1
is: Q59EA4
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r2087
type: Reaction
modifier: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110046#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110046#
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_88187f35_d998_46e4_88c3_1e754cec5f6f
name: HKDC1
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:80201
initial amount: NaN
is: SBO:0000252
is: B3KT70

metaM co2 x
is: CHEBI:16526
has only substance units: false
initial concentration: 1.0
name: carbon dioxide
constant: false
initial amount: NaN
is: HMDB01967
boundary condition: false
type: Species
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247

metaM odecrn m
initial amount: NaN
is: HMDB01114
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
constant: false
is: C00412
name: octadecenoyl carnitine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57394

metaR FAOXC225C204x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaM sql r
is: CHEBI:15440
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00256
name: squalene
is: SBO:0000247
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial concentration: 1.0

metaR r0926
reversible: false
product: MODEL1310110046#
name: Postulated transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:

metaM dcsptn1crn c
is: HMDB06321
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaR r2088
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR NACHEX11ly
reactant: MODEL1310110046#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
product: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110046#
type: Reaction

metaM n2m2nmasn l
initial concentration: 1.0
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
type: Species
initial amount: NaN
has only substance units: false
is: C04946
constant: false
is: SBO:0000247
boundary condition: false

metaR r0661
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110046#

metaM taur e
name: Taurine
initial concentration: 1.0
constant: false
is: C00245
boundary condition: false
is: CHEBI:3544
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
initial amount: NaN

metaR C10OHc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaR OCTDECCACT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_6bce9235_9726_4e15_8c1d_c7415f76ffda
is encoded by: hsa:7357
type: Species
boundary condition: true
has only substance units: false
constant: false
is: Q16739
name: UGCG
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM fprica c
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
constant: false
type: Species
initial amount: NaN
is: CHEBI:58467
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C04734
is: SBO:0000247
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01439

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_6e15d5de_9359_414b_b70f_0aab4b1680bd
initial concentration: NaN
is encoded by: hsa:5281
type: Species
is: Q07326
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PIGF
constant: false
has only substance units: false

metaR THMMPtm
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
reversible: true
name: Thiamine monophosphate transport, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM ksi pre20 g
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 20
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaR CSAPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
product: MODEL1310110046#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
reversible: false
is described by: ECO:0000000

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR r2089
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM CE2421 m
name: (3S)-3-hydroxylinoleoyl-CoA
is: HMDB02329
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
has only substance units: false
is: CHEBI:30623
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_373d6cba_f996_49b7_96c5_33b68eb9b878
is: P50993
is encoded by: hsa:477
name: ATP1A2
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaM dd2coa m
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
initial concentration: 1.0
constant: false
name: trans-dodec-2-enoyl-CoA(4-)
is: CHEBI:57330
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_939e9135_066f_4fba_84c2_7472d9fc5950
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:8706
initial concentration: NaN
is: B3KTQ4
is: SBO:0000252
type: Species
boundary condition: true
name: B3GALNT1

http://identifiers.org/biomodels.db/MODEL1310110046#_aecc0d12_f9af_4739_852c_29d97e75c4ab
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
name: _AI345944_1_m
is encoded by: hsa:AI345944
initial amount: NaN

metaR SERASNNaEx
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110046#
product: MODEL1310110046#
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
reversible: false
reactant: MODEL1310110046#

metaM occoa c
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: C01944
is: HMDB01070
has only substance units: false
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaR PCRNtc
name: transport into the cytosol from peroxisome (carnitine)
type: Reaction
kinetic law: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
fast: false
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
is described by: ECO:0000000

metaR OROTGLUt
is described by: ECO:0000134
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: OROTGLUt
product: MODEL1310110046#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
type: Reaction

metaR EX 3octdece1crn
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_4cbba47f_ba6f_4cbb_aa7a_800fe17fe0ae
name: HSD11B1
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3290
initial amount: NaN
is: P28845
is: SBO:0000252

metaR G6PDH2rer
reversible: true
modifier: MODEL1310110046#
is: SBO:0000176
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110046#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000269

metaR r0924
reactant: MODEL1310110046#
product: MODEL1310110046#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.204.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15209530 NOTES:
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#

metaM ksi deg8 l
name: keratan sulfate I, degradation product 8
is: HMDB00143
type: Species
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR G14T15g
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110046#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110046#_6c34b60c_4e08_4c08_b319_cb520f1860e8
has only substance units: false
constant: false
name: LCAT
type: Species
is: P04180
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3931
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_a3056cee_f481_4da3_aaad_719e68b13189
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _U52111_1_c
is encoded by: hsa:U52111
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_aa62da56_c04c_424e_ac8f_1c59dc1fc31d
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:6519
name: SLC3A1
is: Q07837
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_0c9ad3c5_ba44_44b1_b4b3_b13c0116ed1f
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q15738
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:50814
constant: false
name: NSDHL

metaM ksi deg14 l
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 14
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: HMDB00143
is: CHEBI:12936
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b1bc72ce_f3ab_4e06_ad0d_2880b67c74af
constant: false
is encoded by: hsa:22978
is: P49902
initial amount: NaN
boundary condition: true
type: Species
name: NT5C2
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_6c202c62_71b2_4806_955b_2a1f4700af0e
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:9380
boundary condition: true
has only substance units: false
name: GRHPR
is: Q9UBQ7
initial concentration: NaN
initial amount: NaN

metaM fru e
constant: false
name: D-Fructose
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00660
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
is: C00095
type: Species
boundary condition: false
is: CHEBI:15824

http://identifiers.org/biomodels.db/MODEL1310110046#_10d8df62_e340_41fe_81f8_8f7cfcfd8abb
initial concentration: NaN
is: B7Z9T9
is encoded by: hsa:5158
name: PDE6B
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species

metaR PAIL HStn
is described by: ECO:0000000
name: phosphatidylinositol nuclear transport (diffusion)
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaM itaccoa m
is: CHEBI:57381
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
type: Species
has only substance units: false
constant: false
name: itaconyl-CoA(5-)
is: HMDB03377
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_b142d764_c9ed_4c84_8345_72608c2c1634
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:4700
type: Species
name: NDUFA6
has only substance units: false
is: P56556

metaR TAURtcx
reactant: MODEL1310110046#
fast: false
name: taurine transport (sodium symport) (cytosol to peroxisome)
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110046#_6151d90e_b052_4dc7_aad6_73467a675e36
is: Q96AT9
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6120
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: RPE

http://identifiers.org/biomodels.db/MODEL1310110046#_0bdf19fe_1f8a_427e_b3bc_fcf5db652c0b
is: P19174
boundary condition: true
has only substance units: false
is encoded by: hsa:5335
name: PLCG1
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

metaR BALABETAtc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaM lald L c
is: SBO:0000247
name: (S)-lactaldehyde
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:18041
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
initial amount: NaN
constant: false
has only substance units: false
is: HMDB03052

metaM c12dc x
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB11123
initial amount: NaN
notes: FORMULA: C19H34NO6 CHARGE: -1
is: SBO:0000247
has only substance units: false
name: dodecanedioyl carnitine
is: C05279

metaM HC01401 m
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27668
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_bc0aa8ee_6a6f_4079_acbd_4fb25cbdfd2b
initial amount: NaN
is encoded by: hsa:56606
initial concentration: NaN
name: SLC2A9
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is: Q9NRM0

metaR SUCOASm
fast: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.5
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9c8be00a_6e08_4eb0_9e2c_48a680fa4fce
is: SBO:0000252
type: Species
is encoded by: hsa:6817
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: SULT1A1
constant: false

metaM dpcoa m
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
is: CHEBI:57328
is: HMDB01373
is: SBO:0000247
constant: false
boundary condition: false
name: 3'-dephospho-CoA(2-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM arachdcrn c
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01322
is: CHEBI:57387
constant: false
initial concentration: 1.0

metaM nmn c
name: NMN
type: Species
boundary condition: false
constant: false
is: CHEBI:14649
is: HMDB00229
initial amount: NaN
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: C00455
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM o2 x
is: HMDB01377
name: O2
has only substance units: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: SBO:0000247
type: Species
is: C00007
constant: false
is: CHEBI:15379
initial concentration: 1.0

metaM ser D e
has only substance units: false
name: D-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB03406
is: CHEBI:16523
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_866b1119_3058_4e2f_b2a8_4abba4cdb5db
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:5152
type: Species
name: PDE9A
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_851365a8_c21b_485a_abcc_e5ba9d166f7c
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4714
is: SBO:0000252
name: NDUFB8
type: Species
has only substance units: false
is: O95169

metaR PCRNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
type: Reaction
product: MODEL1310110046#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110046#
name: transport into the mitochondria from cytosol (carnitine)
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9855cbcc_131c_4157_8306_c9a2900d1ab6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:26279
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: Q9UNK4
name: PLA2G2D

metaM HC00695 m
has only substance units: false
name: S-Succinyldihydrolipoamide
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
boundary condition: false
is: CHEBI:17432
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r2514
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
name: Utilized transport
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_7030d54d_efae_47ae_aeac_629fbfb1621f
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6546
boundary condition: true
type: Species
name: SLC8A1
constant: false
is: F6VPY9
initial amount: NaN
is: SBO:0000252

metaM sphmyln hs g
name: sphingomyelin betaine
initial amount: NaN
type: Species
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58216

metaR O2Stm
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110046#
reversible: true

metaR ABTti
is: SBO:0000185
name: L-arabinitol transport via passive diffusion
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_ad09949c_2b51_4d69_b7d7_d99cd0ac772a
is encoded by: hsa:8560
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: DEGS1

http://identifiers.org/biomodels.db/MODEL1310110046#_cdbaca9f_ad23_4195_8886_7144e9b4a7ae
initial concentration: NaN
is encoded by: hsa:23533
initial amount: NaN
has only substance units: false
name: PIK3R5:PIK3CG
has part: Q8WYR1
is: SBO:0000297
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_bd46abaa_ad8c_4971_ac1f_71be8c3ab772
has only substance units: false
initial concentration: NaN
name: PIK3C2B
is: O00750
is: SBO:0000252
is encoded by: hsa:5287
type: Species
initial amount: NaN
constant: false
boundary condition: true

metaR CYSGLNNaEx
reversible: false
is: SBO:0000185
reactant: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110046#
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
modifier: MODEL1310110046#

metaM cholcoa x
is: CHEBI:57373
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: choloyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374

http://identifiers.org/biomodels.db/MODEL1310110046#_fc23d73e_f6e2_4d59_a950_57addbb5efbc
initial concentration: NaN
constant: false
boundary condition: true
is: P61457
has only substance units: false
type: Species
name: PCBD1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5092

http://identifiers.org/biomodels.db/MODEL1310110046#_28002c24_6405_41b9_a549_cdea4635de71
constant: false
type: Species
initial concentration: NaN
name: GCK
boundary condition: true
has only substance units: false
is encoded by: hsa:2645
initial amount: NaN
is: SBO:0000252
is: Q53Y25

http://identifiers.org/biomodels.db/MODEL1310110046#_57a03b87_4840_4b2a_ba7e_d816a00918e0
has part: O95167
has part: O75489
has part: O43181
has part: P56556
is encoded by: hsa:4715
has part: Q85KV6
is encoded by: hsa:4711
is encoded by: hsa:4725
has part: Q9Y6M9
has part: P03897
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q7GXZ4
initial concentration: NaN
has part: Q7GXZ1
is encoded by: hsa:4726
is encoded by: hsa:4719
is encoded by: hsa:4720
has part: O43678
is encoded by: hsa:4705
is encoded by: hsa:4538
has part: Q13454
is encoded by: hsa:4701
is encoded by: hsa:4728
has part: Q6IBA0
is encoded by: hsa:4539
is encoded by: hsa:51079
is encoded by: hsa:4702
is encoded by: hsa:4535
is encoded by: hsa:4709
is encoded by: hsa:4710
is encoded by: hsa:4694
is encoded by: hsa:374291
is encoded by: hsa:4718
has part: O75251
has part: O95169
is encoded by: hsa:4540
has part: Q9P0J0
has part: P19404
has part: H7C5B8
is encoded by: hsa:126328
is encoded by: hsa:7991
has part: P17568
is encoded by: hsa:4731
is encoded by: hsa:4716
is encoded by: hsa:4712
has part: O00217
is encoded by: hsa:55967
is encoded by: hsa:4713
has part: P03915
has part: O95299
is encoded by: hsa:4698
has part: F8VQS7
is encoded by: hsa:4722
is encoded by: hsa:4729
has part: Q6IB80
has part: P28331
is encoded by: hsa:4536
is encoded by: hsa:4695
has part: O95168
has part: Q6FG42
initial amount: NaN
is encoded by: hsa:4696
has part: Q16795
has part: C9JT23
has part: P56181
has part: Q7GXY9
is encoded by: hsa:4706
has part: O95139
is encoded by: hsa:4723
has part: Q549M5
is encoded by: hsa:4724
has part: O75438
constant: false
has part: B1AM93
type: Species
has part: O43677
has part: O43674
has part: Q16718
has part: B7Z792
has part: Q6IBB5

http://identifiers.org/biomodels.db/MODEL1310110046#_b89d11d1_7e7a_4242_a750_1771ce075e3f
is encoded by: hsa:6241
name: RRM2
is: P31350
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_0a9aaea6_4f06_4234_b900_91e039b26942
boundary condition: true
is: P08236
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2990
is: SBO:0000252
name: GUSB
constant: false
initial amount: NaN
type: Species

metaM acetone m
name: acetone
is: SBO:0000247
is: CHEBI:15347
is: HMDB01659
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
type: Species

metaM tre e
is: C01083
name: Trehalose
is: CHEBI:16551
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00975
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false

metaR O2Stn
product: MODEL1310110046#
type: Reaction
fast: false
reactant: MODEL1310110046#
name: superoxide anion transport via diffusion (nucleus)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185

metaM ser D c
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16523
is: HMDB03406
type: Species
initial amount: NaN
has only substance units: false
name: D-serine

metaM CE5236 c
has only substance units: false
is: CHEBI:28002
is: SBO:0000247
initial concentration: 1.0
is: HMDB03952
constant: false
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_4a439a2d_5587_47fd_8088_28e385b71f8d
is encoded by: hsa:10905
initial amount: NaN
boundary condition: true
name: MAN1A2
constant: false
has only substance units: false
type: Species
is: O60476
initial concentration: NaN
is: SBO:0000252

metaM 1pyr5c m
boundary condition: false
is: C03912
constant: false
initial concentration: 1.0
is: HMDB01301
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
type: Species
is: CHEBI:15893

http://identifiers.org/biomodels.db/MODEL1310110046#_3cb5b76c_9b93_4b06_ab0a_a1a3e21d76d2
initial concentration: NaN
is: P35575
is: SBO:0000252
is encoded by: hsa:2538
boundary condition: true
name: G6PC
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM ksi deg4 l
is: HMDB00868
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57737
initial amount: NaN
constant: false
has only substance units: false
name: keratan sulfate I, degradation product 4

http://identifiers.org/biomodels.db/MODEL1310110046#_547d2d56_216e_4035_b868_17da0b72918b
is: SBO:0000252
name: SOD1
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:6647
is: P00441

metaR C160CRNt
reversible: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: C160 transport into the mitochondria
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_870a57f7_63dd_4b8f_94c0_b083a06ac821
name: _R39999_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:R39999
has only substance units: false

metaR FUCASE2ly
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
name: alpha-fucosidase, lysosomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_049467db_3415_4f20_b32f_7696a1b607aa
name: MANBA
is: O00462
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4126
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR XYLTD Dr
fast: false
reversible: true
kinetic law: MODEL1310110046#
type: Reaction
name: xylitol dehydrogenase (D-xyulose-forming)
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
is: SBO:0000176
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_31439e19_7293_4ab1_bea7_6bf4ad71ac8e
constant: false
name: NDUFA1
boundary condition: true
is encoded by: hsa:4694
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q6IBB5
type: Species
initial concentration: NaN

metaR r1620
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
fast: false

metaR AG13T11g
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110046#

metaR PETHCT
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: phosphoethanolamine cytidyltransferase
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.14
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110046#_b594def9_6456_484d_9025_042b55da81df
name: ADH6
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:130
is: P28332
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_596c5ad2_5f30_4e65_a8c3_90ad1d11ae5c
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: P49441
name: INPP1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3628

http://identifiers.org/biomodels.db/MODEL1310110046#_985b45fa_5e80_437b_ac2d_1f91449b9ca8
initial concentration: NaN
name: _AI653169_1_c
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:AI653169
has only substance units: false

metaR RE1517M
is described by: ECO:0000000
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110046#
reversible: true
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
fast: false

metaM CE5160 r
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
name: 3-oxo-cis-9-octadecenoyl-CoA
is: SBO:0000247
type: Species
is: CHEBI:57923
boundary condition: false
constant: false

metaR KCC2t
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransporter (NH4+)
reversible: true
fast: false

metaM ksii core2 pre5 g
type: Species
is: HMDB00175
is: C00130
is: CHEBI:58053
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false

metaM retinol c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
name: retinol
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00305
initial amount: NaN
is: CHEBI:50211
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b93d37b1_f8db_4ecc_a0b2_d72018078b89
is: Q7GXZ8
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: COX2
has only substance units: false
is encoded by: hsa:4513
type: Species

metaM eitetcoa m
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
name: 5,8,11,14-eicosatetraenoylcoa
boundary condition: false

metaM hxan c
initial amount: NaN
is: C00262
name: Hypoxanthine
constant: false
is: CHEBI:17368
has only substance units: false
initial concentration: 1.0
is: HMDB00157
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262

metaM dhbpt c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:20680
is: HMDB00038
has only substance units: false
name: 6,7-dihydrobiopterin
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_4278bf93_a0df_40b7_aac7_5c6c39f19355
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5143
initial amount: NaN
is: Q7KYS4
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: PDE4C

metaR LSTO1r
fast: false
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.21.6
type: Reaction
is: SBO:0000176
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
name: Lathosterol oxidase
modifier: MODEL1310110046#
reversible: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR r2510
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
name: Utilized transport
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction

metaM od2coa m
initial amount: NaN
is: CHEBI:50570
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
type: Species
boundary condition: false
is: HMDB06529
name: trans-Octadec-2-enoyl-CoA
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

metaR RETFA
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110046#
fast: false
name: retinol acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110046#

metaM dhlam m
name: dihydrolipoamide
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00985
is: SBO:0000247
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
constant: false
initial concentration: 1.0
is: CHEBI:17694
has only substance units: false

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_12710b3a_8512_4ef3_a9b4_0da8769d537e
is: O76062
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7108
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: TM7SF2

http://identifiers.org/biomodels.db/MODEL1310110046#_75484523_3cee_400b_88c7_619d15c0ccb2
is: E9PDK1
boundary condition: true
is encoded by: hsa:83697
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC4A9
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_945557cc_d80b_4ef4_b382_26ddeadab1e6
name: FOLR1
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2348

metaR INSTt4
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110046#
name: inositol transport via sodium symport
reversible: true
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_465b0c42_f945_4d47_b2a7_3f7be6646a95
boundary condition: true
is encoded by: hsa:52
initial amount: NaN
is: SBO:0000252
is: Q59EH3
has only substance units: false
initial concentration: NaN
name: ACP1
constant: false
type: Species

metaM CE5132 n
type: Species
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
has only substance units: false
is: CHEBI:57923
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132

metaR SERCYSNaEx
fast: false
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110046#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#

metaM ru5p D r
initial concentration: 1.0
is: HMDB00618
is: CHEBI:58121
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
constant: false
boundary condition: false
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_cf36e19e_b5d7_456f_82c6_f1bf4aa8e9ef
is: Q9Y227
is encoded by: hsa:9583
type: Species
constant: false
initial amount: NaN
name: ENTPD4
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_7277df9d_4e87_4b69_8635_a42275721c76
is encoded by: hsa:55293
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q8IX04
type: Species
name: UEVLD
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7d66f0c6_6b53_459a_a0da_c60ae9b741a2
is: P41247
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8228
has only substance units: false
name: PNPLA4
initial amount: NaN

metaR TRPHYDRO2
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.16.4
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
reversible: false

metaR CERT2rt
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
reversible: true
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110046#
product: MODEL1310110046#

metaR AHCYSte
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
name: Transport of S-adenosyl-L-homocysteine
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
product: MODEL1310110046#

metaR LCAT1e
reactant: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.43
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (3931.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.43 Confidence Level: 4 AUTHORS: PMID:11435418,PMID:11966470 NOTES:NJ
is described by: ECO:0000000
type: Reaction
name: Lecithin-cholesterol acyltransferase
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110046#

metaR AHCYStd
name: diffusion of S-Adenosyl-L-homocysteine
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
is described by: ECO:0000134
is: SBO:0000185
reversible: true
reactant: MODEL1310110046#
type: Reaction

metaR SFGTH
kinetic law: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
product: MODEL1310110046#
name: S-Formylglutathione hydralase
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.12
type: Reaction
reactant: MODEL1310110046#

metaM 3hibutcoa m
is: CHEBI:28259
is: HMDB01052
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxyisobutyryl-CoA
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247

metaM hxan e
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
initial concentration: 1.0
name: hypoxanthine
is: CHEBI:17368
initial amount: NaN
is: HMDB00157

metaR G3PD1
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.8
kinetic law: MODEL1310110046#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
product: MODEL1310110046#
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f2fcdfe0_65d1_47d1_bbd0_44efb15d62ac
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: _AA977580_1_c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA977580
constant: false

metaR ACETONEt2m
reversible: true
fast: false
name: acetone mitochondrial transport via proton symport
modifier: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185

metaR ADPCOACROT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR EX c6crn
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaR P45027A11m
is: SBO:0000176
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
reversible: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
fast: false
is described by: ECO:0000269
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction

metaR S6TASE8ly
reversible: true
kinetic law: MODEL1310110046#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM 2mop m
is: CHEBI:57700
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01172
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5797b015_1fa7_4c5b_b386_a7e1092ea349
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:2983
is: Q02153
name: GUCY1B3
constant: false
initial concentration: NaN

metaR LEUt5m
is: SBO:0000185
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
name: leucine mitochondrial transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
reactant: MODEL1310110046#
type: Reaction

metaM HC00319 c
constant: false
boundary condition: false
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:30794
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5966e55e_a0a4_45fc_a362_8b77f0371f30
constant: false
initial concentration: NaN
is: Q9H6R3
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ACSS3
type: Species
has only substance units: false
is encoded by: hsa:79611

metaM retinal c
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
type: Species
is: CHEBI:15035
initial amount: NaN
initial concentration: 1.0
is: HMDB01358
constant: false
name: retinal
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f0162823_ffe7_4e1c_a454_56fe118945f6
initial concentration: NaN
type: Species
name: HSD3B2
is encoded by: hsa:3284
constant: false
boundary condition: true
is: P26439
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM hxcoa x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: HMDB00705

metaR 4PYRDX
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
fast: false
type: Reaction
name: 4-Pyridoxal secretion

metaM sphmyln hs c
is: SBO:0000247
is: CHEBI:58216
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine

metaM dpcoa l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: 3'-dephospho-CoA(2-)
type: Species
is: CHEBI:57328
is: HMDB01373
constant: false
has only substance units: false
boundary condition: false

metaM 4hglusa m
boundary condition: false
constant: false
name: L-4-hydroxyglutamic semialdehyde
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: HMDB06556
has only substance units: false
is: CHEBI:27809
type: Species
is: SBO:0000247

metaM ksi pre25 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 25
type: Species
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: HMDB00175
is: C00130
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:58053
is: SBO:0000247
initial concentration: 1.0

metaR r1568
type: Reaction
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CLFORtex
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: false
fast: false
is described by: ECO:0000304
modifier: MODEL1310110046#
name: chloride transport via formate countertransport
type: Reaction
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110046#
product: MODEL1310110046#

metaR r1624
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_be07f170_e917_4742_96ae_08e21f851021
type: Species
initial concentration: NaN
is encoded by: hsa:10998
is: Q9Y2P5
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC27A5
is: SBO:0000252
constant: false

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR HMGCOAtx
reversible: true
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
fast: false

metaR XYLUR
name: xylulose reductase
is version of: http://identifiers.org/ec-code/1.1.1.10
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is: SBO:0000176
fast: false

metaR FAOXC2251836m
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110046#
name: Beta oxidation of fatty acid
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110046#

metaM dpcoa e
is: C00882
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Dephospho-CoA
type: Species
is: CHEBI:57328
constant: false
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial concentration: 1.0

metaM m8masn r
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05876

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:10986
is: C03492
is: SBO:0000247
is: HMDB01016
initial concentration: 1.0
boundary condition: false
name: D-4'-Phosphopantothenate

metaM CE5586 c
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
boundary condition: false
has only substance units: false
is: CHEBI:58732
initial concentration: 1.0
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaR r1569
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM xol25oh r
boundary condition: false
is: CHEBI:42977
is: HMDB06247
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
name: 25-hydroxycholesterol
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaR r1623
kinetic law: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gal c
is: CHEBI:0
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose
constant: false
is: C00124
has only substance units: false
is: SBO:0000247
type: Species

metaR FBA2
is: SBO:0000176
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000304
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110046#

metaM 2mop c
initial concentration: 1.0
is: CHEBI:57700
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
has only substance units: false
name: 2-methyl-3-oxopropanoate
is: HMDB01172
is: SBO:0000247

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
reactant: MODEL1310110046#
name: RE0944
product: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
fast: false

metaR ABTD
fast: false
name: L-arabinitol 4-dehydrogenase
reactant: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD

metaR CSPG Atly
type: Reaction
name: chondroitin sulfate A transport, extracellular to lysosome
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_e22128b0_7e40_41b0_ae40_27277bf05124
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: PLA2G1B
initial concentration: NaN
is encoded by: hsa:5319
constant: false
is: SBO:0000252
is: P04054

http://identifiers.org/biomodels.db/MODEL1310110046#_6f559172_7e89_4be8_9085_27f76b788f95
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110046#_00d6acfd_6a6e_47ce_b701_8d65d2698048
type: Species
constant: false
is: P21953
initial amount: NaN
name: BCKDHB
has only substance units: false
is: SBO:0000252
is encoded by: hsa:594
initial concentration: NaN
boundary condition: true

metaM for r
initial concentration: 1.0
is: HMDB00142
type: Species
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
name: Formate
is: CHEBI:15740
is: C00058
constant: false
has only substance units: false
initial amount: NaN

metaR ASNPHELAT2tc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR O2Stx
kinetic law: MODEL1310110046#
name: superoxide anion transport via diffusion (peroxisome)
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_9a3261e6_86b3_468b_b22f_36237132f102
constant: false
is encoded by: hsa:11136
boundary condition: true
is: P82251
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC7A9
initial amount: NaN
type: Species

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r1622
reactant: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is: SBO:0000185
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000

metaM clpndcoa c
is: SBO:0000247
is: C16166
type: Species
name: clupanodonyl CoA
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06267
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: http://identifiers.org/pubchem.compound/47205476
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_a4e48437_2984_4743_9a0a_75fdf0c8ee47
is: B2RB13
initial concentration: NaN
is encoded by: hsa:23305
is: SBO:0000252
type: Species
name: ACSL6
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

metaM HC00664 c
constant: false
name: D-tagatofuranose 6-phosphate(2-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58695
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_a508c296_59f2_4e31_9964_1500bc8cf764
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P56385
constant: false
name: ATP5I
is encoded by: hsa:521
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_11bc0607_ea6b_4a7c_a949_2377ad44f5d2
is: P06744
boundary condition: true
type: Species
is encoded by: hsa:2821
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: GPI

http://identifiers.org/biomodels.db/MODEL1310110046#_bcdae174_8ef7_494f_a1ed_b097c26e970c
has only substance units: false
type: Species
is: B4DUY1
is: SBO:0000252
constant: false
is encoded by: hsa:10948
initial amount: NaN
boundary condition: true
name: STARD3
initial concentration: NaN

metaR CRNtim
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110046#
name: L-carnitine transport out of mitochondria via diffusion
type: Reaction
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000269
reversible: false
product: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#

metaR XYLt
reversible: true
modifier: MODEL1310110046#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
fast: false
name: D-xylose reversible transport
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is described by: ECO:0000269

metaR CHAT
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
type: Reaction
reversible: true
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110046#_3897e6ac_f131_4c8a_9123_943cb21c9397
is: O60760
name: HPGDS
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:27306
constant: false
has only substance units: false
is: SBO:0000252

metaR r1418
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
fast: false
kinetic law: MODEL1310110046#
reversible: true
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
is: SBO:0000176

metaM gal e
name: D-Galactose
initial amount: NaN
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
constant: false
is: C00124
is: CHEBI:0

metaR DESAT22 2p
reactant: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
is: SBO:0000176
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_1679cf07_6afe_4398_adcb_61675c5fe264
name: CYP27A1
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q02318
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:1593

metaR XYLTt
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
name: Xylitol transport via passive diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#

metaR 4NPHSULT
type: Reaction
fast: false
product: MODEL1310110046#
name: 4-Nitrophenol Sulfotransferase
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.8.2.1

metaR FBA4
modifier: MODEL1310110046#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110046#

metaR GCCam
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoylprotein), mitochondrial
reversible: true

metaM phytcoa c
is: HMDB01359
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: CHEBI:57391
has only substance units: false
constant: false
name: phytanoyl-CoA(4-)
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_32641934_6472_46aa_b2f3_87bb5ed89408
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7378
name: UPP1
initial concentration: NaN
constant: false
has only substance units: false

metaR NADHtpu
is: SBO:0000185
reactant: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
name: NADH transporter, peroxisome
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

metaR OCD11CRNCACT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR r1621
product: MODEL1310110046#
fast: false
type: Reaction
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110046#
is: SBO:0000185

metaM eitetcoa x
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: 5,8,11,14-eicosatetraenoylcoa
initial concentration: 1.0

metaM dmpp x
type: Species
name: prenyl diphosphate(3-)
is: CHEBI:57623
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
initial amount: NaN
is: HMDB01120
has only substance units: false

metaM HC00319 m
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:30794
type: Species
name: Malonate
constant: false

metaR r2519
reversible: true
product: MODEL1310110046#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
name: Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_513853b9_9f88_4461_a361_1f0503b94a60
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: MTMR6
initial amount: NaN
constant: false
is encoded by: hsa:9107
is: Q9Y217
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_bedd6b2d_69da_465f_bf7e_89a738eb783d
is: Q6LEN5
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: CHAT
is encoded by: hsa:1103
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_4473e6ba_dff1_4a30_b14a_e2791ac50714
name: GGT3P
boundary condition: true
has only substance units: false
is encoded by: hsa:2679
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR r1628
reversible: true
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185

metaR ACOX22x
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
name: acyl-Coenzyme A oxidase 2, branched chain
is: SBO:0000176
type: Reaction
reactant: MODEL1310110046#
reversible: false
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.17.99.3
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_0879829b_6a6c_43c8_978c_4a87a7798703
initial amount: NaN
type: Species
initial concentration: NaN
is: Q16836
has only substance units: false
is encoded by: hsa:3033
constant: false
name: HADH
is: SBO:0000252
boundary condition: true

metaR EX 3deccrn
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaM focytC m
initial concentration: 1.0
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
has only substance units: false
type: Species
is: CHEBI:16928
is: SBO:0000247
constant: false
initial amount: NaN
name: Ferrocytochrome C
boundary condition: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR r1564
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
reversible: true
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM m8mpdol L r
type: Species
constant: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
has only substance units: false
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
is: CHEBI:59093
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_93a41f1b_ae6a_4fc1_84de_3ec273eddee8
has only substance units: false
name: NADSYN1
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:55191
is: Q6IA69
initial concentration: NaN

metaR HACD1m
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
type: Reaction
reversible: true
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110046#
is described by: ECO:0000134
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false

metaR S6T11g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110046#
product: MODEL1310110046#
reversible: false

metaR HISCAT1
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR DECDPtm
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
name: lipid, flip-flop intracellular transport
reversible: true
is: SBO:0000185

metaM s2l2n2m2mn l
notes: FORMULA: C76H123N5O57 CHARGE: -2
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
has only substance units: false
is: HMDB00573
type: Species
is: SBO:0000247
is: CHEBI:30825
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9d8cfd25_9f08_4a9b_8b57_66cfb65bc649
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: SLC13A5
is: Q86YT5
initial concentration: NaN
is encoded by: hsa:284111
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_84441b79_e2f1_4c07_b4ed_91470f3dfea6
boundary condition: true
is: O95477
initial amount: NaN
is encoded by: hsa:19
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: ABCA1
constant: false

metaR PI45P5P
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is: SBO:0000176
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
type: Reaction
reversible: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110046#

metaR r1627
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110046#_f37ea37d_b80b_48ea_95ea_39b67885aec0
is encoded by: hsa:26062
type: Species
initial amount: NaN
name: HYALP1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR r1565
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR RE2625C
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110046#
name: RE2625
type: Reaction
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110046#

metaM eicostetcoa m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
constant: false
name: eicosatetranoyl coenzyme A
is: C16164
boundary condition: false
type: Species

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_14b08fb7_e770_4fa4_9c54_ca6a3fd007c6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:514
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: P56381
name: ATP5E
initial amount: NaN

metaM 13dampp c
constant: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: HMDB00002
initial concentration: 1.0
name: trimethylenediaminium
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57484
is: SBO:0000247
boundary condition: false

metaM dpcoa c
is: SBO:0000247
name: Dephospho-CoA
is: C00882
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:57328
is: HMDB01373
has only substance units: false

metaR GSNt
reactant: MODEL1310110046#
name: guanosine facilated transport in cytosol
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false

metaR r1626
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000

metaR OMHPALTD
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_d8db7e61_c5d7_4839_98fd_19f4b5dbca47
is encoded by: hsa:84890
boundary condition: true
initial amount: NaN
is: B3KXN9
has only substance units: false
type: Species
constant: false
name: ADO
initial concentration: NaN
is: SBO:0000252

metaM glyclt c
initial concentration: 1.0
is: CHEBI:29805
is: SBO:0000247
is: HMDB00115
constant: false
initial amount: NaN
name: glycolate
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

metaR r1566
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d84c1dce_1c99_4d68_89e4_894b9f3602d4
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:54
initial amount: NaN
is: P13686
initial concentration: NaN
name: ACP5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_4eb8f374_d7fb_4cd7_9980_d04b0b2d466e
initial concentration: NaN
name: PDE6G
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5148
constant: false
is: P18545
initial amount: NaN
type: Species

metaR FAOXC102C101m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM ala L m
initial amount: NaN
is: CHEBI:16977
has only substance units: false
is: SBO:0000247
type: Species
name: L-alanine
is: HMDB00161
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false

metaR ASPTAm
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reactant: MODEL1310110046#
name: aspartate transaminase
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR DURAD
is described by: ECO:0000269
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
product: MODEL1310110046#
is: SBO:0000176
name: dihydrouracil dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110046#

metaR r1567
reversible: true
fast: false
type: Reaction
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_a6741deb_dd11_4da6_9da4_a415b13cd4f3
is: P22234
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10606
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PAICS
type: Species

metaR C9BRxtc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaM ha deg1 l
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16336
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1
has only substance units: false
name: hyaluronan degradation product 1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_98c8729d_6e94_475d_a640_f2354a1a13bc
constant: false
type: Species
is encoded by: hsa:6517
is: P14672
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC2A4
has only substance units: false

metaM dump n
is: CHEBI:246422
name: dUMP(2-)
is: HMDB01409
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_89835b1c_4304_43f6_81f4_9ecc17e9b6fb
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: SLC10A2
has only substance units: false
initial amount: NaN
is: Q12908
is encoded by: hsa:6555

http://identifiers.org/biomodels.db/MODEL1310110046#_8995c2d2_520c_4eb9_9b73_4db1c9c64a9d
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:6487
initial amount: NaN
type: Species
initial concentration: NaN
name: ST3GAL3

metaR DNDPt33m
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reactant: MODEL1310110046#
name: dGDP transport via dUDP antiport
is described by: ECO:0000269
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
reversible: false

metaR RBFK
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: riboflavin kinase
reversible: false
reactant: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.26
fast: false
modifier: MODEL1310110046#

metaR CERT1rt
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110046#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
name: ceramide transport protein
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110046#_341954e0_3453_42c1_8862_735f860d47c5
name: MPST
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P25325
is: SBO:0000252
type: Species
is encoded by: hsa:4357
initial amount: NaN
constant: false

metaM CE5101 m
is: SBO:0000247
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: CHEBI:57795
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110046#_d5df03b2_e3f9_47c7_b8cb_43391417ddb4
constant: false
is: SBO:0000252
has only substance units: false
name: _AI348006_1_c
is encoded by: hsa:AI348006
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR CSBPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_43cd6c72_2ff5_4b9a_afff_e94b02c798b7
name: KL
has only substance units: false
is encoded by: hsa:9365
boundary condition: true
is: SBO:0000252
is: Q9UEF7
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM adrncoa c
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
name: adrenyl coenzyme A
is: SBO:0000247
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/47205480
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_04b94b63_2c47_4db3_ade3_bdd5232d4515
name: ALPI
is: P09923
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:248
constant: false

metaR RTOTAL3FATPc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaR GCHOLAte
product: MODEL1310110046#
fast: false
reversible: true
name: bile acid intracellular transport
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110046#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM 2dp6mobq m
constant: false
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
type: Species
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
initial amount: NaN
is: CHEBI:50773
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR RE2079R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
type: Reaction
is: SBO:0000176
name: RE2079
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000
fast: false

metaR PCHOLPr hs
is described by: ECO:0000269
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
name: choline phosphatase
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_c25e9f32_fd5e_4289_ba85_2c8edd4f755c
type: Species
initial concentration: NaN
is encoded by: hsa:6647
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: SOD1
is: P00441
has only substance units: false

metaR RE3000M
reversible: true
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
name: RE3000
fast: false
reactant: MODEL1310110046#

metaR FAOXC241C221x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaR r0913
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110046#
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_994f3087_8c03_49ba_b297_04da7f59645a
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: OGDHL
is encoded by: hsa:55753
constant: false
is: Q9ULD0
boundary condition: true
type: Species

metaM man l
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
is: CHEBI:16024
initial amount: NaN
is: SBO:0000247
name: D-mannose
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00169
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_81eb5e5c_5610_4ade_9b0e_04b07df3937c
type: Species
has only substance units: false
name: MPI
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:4351
boundary condition: true
is: SBO:0000252
is: P34949

metaM cmpacna n
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_0f3f05a7_ac52_410b_a2c1_ed5abcde72fd
constant: false
type: Species
is: Q5TDP6
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51557
name: LGSN

http://identifiers.org/biomodels.db/MODEL1310110046#_cf3741b1_7b2b_48c1_a1f2_1d6ffa1e28e1
name: ACSL5
type: Species
initial amount: NaN
is encoded by: hsa:51703
is: SBO:0000252
constant: false
is: Q9ULC5
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR CHSTEROLt1
reactant: MODEL1310110046#
is described by: ECO:0000304
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: cholesterol intracellular transport
fast: false
is: SBO:0000185
reversible: true

metaM dcdp c
is: CHEBI:58593
name: dCDP
type: Species
initial concentration: 1.0
is: C00705
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01245

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_16b42742_fe43_43d2_8fd7_20f20728a2bd
is: O95674
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:8760
boundary condition: true
name: CDS2
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_1833643c_2f10_4d25_808e_2c78b85f8e79
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7389
name: UROD
initial concentration: NaN
is: P06132
has only substance units: false
type: Species

metaR BILIRUBtr
reversible: true
type: Reaction
fast: false
is: SBO:0000185
name: lipid, flip-flop intracellular transport
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110046#

metaR DNDPt45m
is described by: ECO:0000269
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
reversible: false
product: MODEL1310110046#
fast: false
name: dTTP transport via ADP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110046#

metaM strdnccoa x
is: SBO:0000247
constant: false
is: C16163
is: http://identifiers.org/pubchem.compound/47205473
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
type: Species
initial amount: NaN
name: stearidonyl coenzyme A
has only substance units: false
is: HMDB06519
boundary condition: false

metaM pyam5p c
is: SBO:0000247
constant: false
is: C00647
initial amount: NaN
is: HMDB01555
is: CHEBI:58451
initial concentration: 1.0
type: Species
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
has only substance units: false
name: Pyridoxamine 5'-phosphate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_fafbb30c_8784_4aa5_be8b_8335435d553e
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: B2RD24
name: MTHFD1L
is encoded by: hsa:25902
boundary condition: true
type: Species

metaR FAOXC204C184m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaM tmndnccoa m
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
has only substance units: false
name: timnodonyl coenzyme A
is: HMDB06514
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM Rtotal3 e
constant: false
is: C00255
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00244
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: SBO:0000247
is: CHEBI:3554
type: Species
name: R total 3 position

metaM HC00900 c
initial concentration: 1.0
boundary condition: false
is: CHEBI:30860
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
has only substance units: false
constant: false
type: Species
name: Methylmalonate
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_c41ac295_8f9d_4d0f_935b_e57b090fc72f
has only substance units: false
is encoded by: hsa:4715
name: NDUFB9
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: Q9Y6M9
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_07317dab_d3c1_47bc_9085_cb6406cf0197
initial amount: NaN
name: PIGO
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:84720
is: SBO:0000252
has only substance units: false

metaR NADH2 u10m
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110046#
name: NADH dehydrogenase, mitochondrial
modifier: MODEL1310110046#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is: SBO:0000185
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.6.5.3
fast: false
reversible: false
reactant: MODEL1310110046#
type: Reaction

metaM hs deg6 l
type: Species
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01352
name: heparan sulfate, degradation product 6
is: CHEBI:17180
initial amount: NaN

metaM cbasp c
name: N-Carbamoyl-L-aspartate
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00828
is: CHEBI:32814
is: C00438
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
boundary condition: false
has only substance units: false

metaM 3oddcoa x
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial amount: NaN
is: CHEBI:27868
type: Species
initial concentration: 1.0
name: 3-Oxododecanoyl-CoA
constant: false
is: HMDB03937
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR AG13T16g
type: Reaction
product: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
fast: false
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110046#

metaM ppcoa c
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
boundary condition: false
is: HMDB01275
name: Propanoyl-CoA
type: Species
constant: false
initial concentration: 1.0
is: C00100
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_3bcd1de6_df87_4933_ba5c_caa8f53b2e9c
type: Species
is: SBO:0000252
is encoded by: hsa:376497
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC27A1
is: Q6PCB7
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_abd6e1b4_9ee7_473d_b6f8_8c56f88ea521
is: Q13370
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5140
name: PDE3B
has only substance units: false
initial amount: NaN
type: Species

metaR r0915
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

metaM 2hexdtetcoa x
constant: false
type: Species
name: 2,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d6e33827_ed7b_4eb0_91c6_f18ca50003b0
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: EHHADH:ACAA1:ACOX1
is encoded by: hsa:1962
has part: Q9NY65
type: Species

metaM val L c
boundary condition: false
initial concentration: 1.0
name: L-valine
type: Species
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
is: HMDB00883
is: CHEBI:16414

http://identifiers.org/biomodels.db/MODEL1310110046#_dcc2ce7f_4263_43fc_a7c9_b44025978698
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:117248
boundary condition: true
is: Q8N3T1
is: SBO:0000252
name: GALNTL2

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM arachdcrn m
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB01322
name: C20:4 carnitine
is: CHEBI:57387
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN

metaM man g
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: D-mannose
is: SBO:0000247
is: CHEBI:16024
is: HMDB00169
type: Species
constant: false

metaR H2O2t
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110046#
name: hydrogen peroxide transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaR DCYTDn
reversible: false
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000254
name: deoxycytidine deaminase, nuclear
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.5.4.5
is: SBO:0000176
reactant: MODEL1310110046#
type: Reaction
fast: false

metaR HPDCACRNCPT1
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reversible: false
is described by: ECO:0000000
name: carnitine fatty-acyl transferase
modifier: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_77eea78c_0b39_4150_90c7_ef37e9925995
is: SBO:0000252
is encoded by: hsa:728637
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: _728637_1_c

http://identifiers.org/biomodels.db/MODEL1310110046#_19252335_f15a_4474_8286_3cc47c96ab1e
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: GMDS
constant: false
is encoded by: hsa:2762
is: O60547
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_efee33b0_9ef0_4c9b_8d7c_beffbe5f3867
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:2877
boundary condition: true
initial concentration: NaN
name: GPX2
is: P18283
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_5e38de44_2311_402f_9412_d3b6d9dbe99d
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11332
type: Species
name: ACOT7
boundary condition: true
is: O00154

metaM HC01180 c
boundary condition: false
is: CHEBI:58694
name: D-tagatofuranose 1,6-bisphosphate(4-)
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_36fe4cba_d032_4e70_ad34_850fa18c0973
type: Species
initial concentration: NaN
boundary condition: true
name: _AA081045_1_m
constant: false
is encoded by: hsa:AA081045
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM tststerone r
type: Species
is: HMDB00234
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17347
name: testosterone
boundary condition: false

metaR FAOXC15ATPx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaM cbasp e
is: C00438
is: CHEBI:32814
is: HMDB00828
type: Species
name: N-Carbamoyl-L-aspartate
has only substance units: false
constant: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM dcyt n
name: 2'-deoxycytidine
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00014
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
constant: false
initial concentration: 1.0

metaR r0917
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
reversible: true

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR HPDCACRNCPT2
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: false
is: SBO:0000176
type: Reaction
name: heptadecanoate transport into the mitochondria
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110046#_e3a12892_d640_47bf_9dc2_67f0b5ef9132
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: TYMS
is: SBO:0000252
is: P04818
is encoded by: hsa:7298

metaR UDPDOLPT L
reactant: MODEL1310110046#
type: Reaction
reversible: false
modifier: MODEL1310110046#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.117
product: MODEL1310110046#
fast: false

metaR CYTK9n
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: cytidylate kinase (CMP,dCTP),nuclear
modifier: MODEL1310110046#
fast: false
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110046#

metaM l2n2m2mn l
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
is: HMDB00143
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_de830614_35d9_4216_a4f5_36055f099444
has only substance units: false
name: _R33828_1_c
initial concentration: NaN
is encoded by: hsa:R33828
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_9da0c77c_27fe_48e8_8e1c_674916e04f06
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: O76062
initial amount: NaN
is encoded by: hsa:7108
name: TM7SF2

http://identifiers.org/biomodels.db/MODEL1310110046#_cf64700f_4fc4_47c2_ac48_f67075ed22d7
is: SBO:0000252
is encoded by: hsa:23539
is: O95907
name: SLC16A8
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_a6d973c7_2025_40e2_a1a4_973d6a4e11ac
has only substance units: false
is encoded by: hsa:51227
has part: Q92535
initial concentration: NaN
constant: false
is encoded by: hsa:9091
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species
is encoded by: hsa:5283
is encoded by: hsa:5279
is: SBO:0000297
has part: Q14442
has part: Q9BRB3
has part: O94777
is encoded by: hsa:5277
is encoded by: hsa:8818
boundary condition: true
has part: B3KUV7

metaR DPHMBDCm
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reversible: false
fast: false
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
type: Reaction
is: SBO:0000176
reactant: MODEL1310110046#

metaR CHSTEROLt2
is: SBO:0000185
name: cholesterol intracellular transport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false

metaM ksii core2 deg6 l
boundary condition: false
is: CHEBI:12936
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: keratan sulfate II (core 2-linked), degradation product 6
initial concentration: 1.0
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: HMDB00143
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_be0b1b03_46b4_4d2a_97f3_360fafbde30d
constant: false
initial amount: NaN
is encoded by: hsa:5315
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PKM2
boundary condition: true

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_13d92458_0cc7_4878_b790_7657f62491e7
name: DPYSL3
is: Q8IXW6
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1809
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR AKGMALtm
type: Reaction
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110046#
name: alpha-ketoglutarate/malate transporter
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR HS2ly
is version of: http://identifiers.org/ec-code/3.10.1.1
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
fast: false
name: heparan-N-sulfatase, lysosomal
reversible: false
product: MODEL1310110046#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110046#

metaR BILGLCURtr
fast: false
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: glucuronidated compound transport
kinetic law: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ

metaR HDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reversible: true
fast: false

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_5ccfb30c_91d7_4359_bb8e_1ae155296d45
initial amount: NaN
is: Q9HCC0
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:64087
name: MCCC2
initial concentration: NaN
is: SBO:0000252

metaR r1050
product: MODEL1310110046#
reversible: true
type: Reaction
name: Vesicular transport
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false

metaR C10DCCACT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_cd1649b0_0ff5_419c_bb05_8ec51296ffa1
is: Q9NX14
name: NDUFB11
type: Species
constant: false
is encoded by: hsa:54539
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_a75185ea_2a4b_473d_97a7_a88dd5824b3f
is encoded by: hsa:43
type: Species
boundary condition: true
name: ACHE
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: P22303
initial concentration: NaN

metaM ksi deg26 l
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
initial amount: NaN
has only substance units: false
is: HMDB00061
name: keratan sulfate I, degradation product 26
type: Species
constant: false
is: CHEBI:58343
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_c3d29038_03a7_419d_8cfa_b882edcf3173
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8704
type: Species
name: B4GALT2
is: SBO:0000252

metaR CHSTEROLt3
fast: false
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
name: cholesterol intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110046#_15ca074f_419c_4cd6_ba09_5bfbdd5106a2
is: F5GY65
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC25A11
has only substance units: false
is encoded by: hsa:8402

http://identifiers.org/biomodels.db/MODEL1310110046#_69a2db90_8038_4152_8273_7df9b6e37438
constant: false
is encoded by: hsa:5730
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PTGDS
is: P41222

metaR METLEUex
name: Methionine/Leucine exchange (Met in)
reversible: false
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000185
fast: false
reactant: MODEL1310110046#
type: Reaction

metaR 5ADTSTSTERONESULT
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
fast: false
modifier: MODEL1310110046#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.14
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
name: 5alpha-Dihydrotestosterone sulfotransferase
product: MODEL1310110046#
is: SBO:0000176

metaM cmpacna g
is: HMDB01176
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false

metaR ADAe
fast: false
name: Adenosine deaminase, extracellular
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110046#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#

metaM tmndnccoa c
is: HMDB06514
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: timnodonyl coenzyme A
initial concentration: 1.0
type: Species
constant: false

metaM dolmanp L c
is: CHEBI:15809
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r2420
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000

metaM hexdicoa x
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: HMDB02288
boundary condition: false
name: hexadecanedioylcoa
initial amount: NaN
initial concentration: 1.0

metaR GALSIDEtl
fast: false
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
reactant: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000

metaR r2109
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
fast: false

metaR r1493
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
type: Reaction
reactant: MODEL1310110046#
name: Utilized transport
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaM retfa e
has only substance units: false
is: CHEBI:15963
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
name: fatty acid retinol
initial amount: NaN
is: SBO:0000247
is: HMDB00508
constant: false

metaR CYANtm
reversible: true
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: Cyanide transport via diffusion (mitochondrial)
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
product: MODEL1310110046#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_a8cc7820_8b5e_44d7_8010_bac1673ec476
constant: false
is encoded by: hsa:200010
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC5A9
boundary condition: true
type: Species
is: SBO:0000252
is: E9PAK4

metaM 4hexdtetcoa x
name: 4,7,10,13-hexadecatetraenoylcoa
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB02288
initial amount: NaN
initial concentration: 1.0

metaM 2hexdtetcoa m
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB02288
has only substance units: false
initial concentration: 1.0
name: 2,7,10,13-hexadecatetraenoylcoa
constant: false
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

metaR GALASE6ly
is described by: ECO:0000000
fast: false
name: beta-galactosidase, lysosomal
reversible: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_c6886fce_25e2_4c3a_834c_a008976a4a88
boundary condition: true
is encoded by: hsa:22305
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: _22305_1_c
initial amount: NaN
constant: false

metaM ksi pre33 g
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: C00130
is: HMDB00175
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 33
has only substance units: false
boundary condition: false

metaR MI4PP
fast: false
modifier: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.25
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: myo-inositol 4-phosphatase
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
reversible: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_292b7cbf_f490_4217_b1a5_cd88eef03acd
is encoded by: hsa:4833
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O00746
name: NME4

metaM r5p c
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
is: HMDB00618
is: SBO:0000247
is: CHEBI:18189
type: Species
is: C00117
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
has only substance units: false
constant: false

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

metaR r2108
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_fe5ad4bf_4495_4bd0_ba14_18f591329323
name: B3GNT2
is: Q9NY97
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:10678
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaM phytcoa x
name: phytanoyl-CoA(4-)
is: CHEBI:57391
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01359
type: Species
has only substance units: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
is: SBO:0000247

metaM hdcecrn c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
is: HMDB00222
constant: false
initial amount: NaN
has only substance units: false
name: Hexadecenoyl carnitine

metaM kynate c
boundary condition: false
initial amount: NaN
is: HMDB00715
is: CHEBI:58454
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
name: kynurenate

http://identifiers.org/biomodels.db/MODEL1310110046#_55d1971b_3070_4d1e_830c_65dc58be939b
initial concentration: NaN
name: SLC6A9
has only substance units: false
constant: false
is: P48067
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:6536

http://identifiers.org/biomodels.db/MODEL1310110046#_0058eeca_404f_4865_92eb_743033d9f929
name: DGKD
is encoded by: hsa:8527
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_edca4cb3_3b75_48b7_8306_7c9ea012cbdb
name: SLC20A2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: B2RBR4
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6575
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_bd2df40b_26f4_42aa_912e_b673aafb4a87
boundary condition: true
initial amount: NaN
name: NDUFAB1
is encoded by: hsa:4706
is: SBO:0000252
is: O14561
type: Species
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_2d77a675_33e4_4da7_875b_1e052ad8fa06
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: B4GALT3
is: A8K5Z0
type: Species
is: SBO:0000252
is encoded by: hsa:8703
initial amount: NaN

metaR S6T4g
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
fast: false
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000

metaR 4NPHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
name: xenobiotic transport
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#

metaM val L e
name: L-valine
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

metaM ksii core2 pre9 g
name: keratan sulfate II biosynthesis, precursor 9
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
has only substance units: false

metaM ura e
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
type: Species
name: uracil
initial amount: NaN
is: CHEBI:17568

metaM m4mpdol L c
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37633
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_a09d647f_a2cf_420a_ab15_d6121c456608
constant: false
is: SBO:0000252
boundary condition: true
name: SULT1A3
is encoded by: hsa:6818
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q1ET61

http://identifiers.org/biomodels.db/MODEL1310110046#_f9cfe9ab_f454_4fee_9bdb_7932115c0109
initial amount: NaN
type: Species
is encoded by: hsa:3099
is: SBO:0000252
is: P52789
boundary condition: true
has only substance units: false
initial concentration: NaN
name: HK2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_e62fe62b_8c69_46ec_904b_4060edd09285
type: Species
is: SBO:0000252
constant: false
name: _BE042354_1_m
is encoded by: hsa:BE042354
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM xol7aone c
type: Species
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
is: CHEBI:17899
initial concentration: 1.0
is: HMDB01993
has only substance units: false
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false

metaM dcdp m
is: CHEBI:58593
is: HMDB01245
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: dCDP(3-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaM dgsn c
constant: false
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
boundary condition: false
is: CHEBI:17172
name: Deoxyguanosine
has only substance units: false
initial concentration: 1.0
is: C00330
is: HMDB00085
type: Species
is: SBO:0000247

metaR r1492
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#
name: Utilized transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#

metaR RE2626M
fast: false
name: RE2626
kinetic law: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR AMPTASECGe
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.11.2
reversible: false
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.2 Confidence Level: 4 AUTHORS: PMID:6126478 NOTES:SAB. rat lumen renal proximal tubule preparation cysteinylglycine metabolism measured due to aminopeptidase M (=N); the annotation in BiGG of strong biochemical evidence in a textbook could not be found in the Google Books version search of this book; intensively sought for human metabolism; human metabolism is likely though not proven directly
fast: false
name: alanyl aminopeptidase (cys-gly) (e)
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269

metaR ARAB Lt
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110046#
name: L-arabinoase extracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5d9e08a4_e711_4433_87b1_cfe6abad8fb2
type: Species
initial amount: NaN
is: SBO:0000252
is: Q08499
boundary condition: true
name: PDE4D
initial concentration: NaN
is encoded by: hsa:5144
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1f1bca8f_a06b_430e_80da_de40e0953b44
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P04179
constant: false
is encoded by: hsa:6648
type: Species
initial concentration: NaN
name: SOD2

metaR GALASE17ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is: SBO:0000176
modifier: MODEL1310110046#
reversible: false
fast: false

metaM dcdp n
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
initial amount: NaN
name: dCDP(3-)
is: HMDB01245
initial concentration: 1.0
has only substance units: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_5c509feb_c4fd_461d_ad45_48f2934a5d98
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51179
type: Species
has only substance units: false
name: HAO2
is: Q9NYQ3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_0e703870_5a1a_4d76_91ca_0d2ac802eddc
type: Species
constant: false
is: C9JC79
initial amount: NaN
has only substance units: false
is encoded by: hsa:6342
name: SCP2
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM m2mn l
is: SBO:0000247
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
initial concentration: 1.0
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
boundary condition: false
constant: false
is: HMDB06537
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_fc2ef14c_62c9_4620_a8bf_9444bd5193f8
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55512
type: Species
is: Q9NY59
name: SMPD3

metaM leuktrC4 c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01198
is: CHEBI:57973
boundary condition: false
name: leukotriene C4(2-)
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
has only substance units: false
constant: false

metaM cmpacna c
initial amount: NaN
is: CHEBI:57812
boundary condition: false
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)

metaM ura c
type: Species
initial concentration: 1.0
name: Uracil
is: SBO:0000247
is: CHEBI:17568
is: C00106
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
initial amount: NaN

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaM c226crn c
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial amount: NaN
is: HMDB06510
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/127055
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: cervonyl carnitine

metaR S6T6g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110046#

metaR UGLCNACtg
is described by: ECO:0000269
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110046#
name: UDP-GlcNAc Golgi transport via CMP antiport
reversible: true
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD

metaM abt c
is: SBO:0000247
constant: false
is: CHEBI:18403
initial amount: NaN
is: HMDB01851
boundary condition: false
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_444d6686_bb45_452b_9a83_684c0d820979
name: DYLX2
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:9856
initial amount: NaN
has only substance units: false
is: F5H123

metaR OCTDECE1CRNe
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaR GK1
is described by: ECO:0000269
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110046#
is: SBO:0000176
fast: false
name: guanylate kinase (GMP:ATP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_7db8dd78_6ccd_4ca0_a077_0fac46eda8d3
initial concentration: NaN
is encoded by: hsa:65263
type: Species
is: SBO:0000252
name: PYCRL
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q53H96
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9494bdfe_df6f_49bb_bb08_a922c32f95cb
is encoded by: hsa:AA278423
name: _AA278423_1_m
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_3694e07a_dcc8_4065_9fd3_a142ef4fed4e
initial amount: NaN
constant: false
is encoded by: hsa:F23536
boundary condition: true
initial concentration: NaN
name: _F23536_1_m
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_83fc0759_cc20_49d5_b338_d809f89c8b1d
has only substance units: false
is encoded by: hsa:1103
name: CHAT
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: D3DX95
type: Species
constant: false
boundary condition: true

metaR PAIL45P HStn
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaM occoa x
is: CHEBI:57386
is: C01944
boundary condition: false
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
initial concentration: 1.0
is: HMDB01070
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_0d5535fb_0845_42f9_a4b0_abf4c2c78cd1
name: PIK3CG
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5294
is: P48736
boundary condition: true
initial amount: NaN

metaR GHMT2r
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
name: glycine hydroxymethyltransferase, reversible
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110046#

metaM 3oddcoa m
initial concentration: 1.0
is: HMDB03937
boundary condition: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: CHEBI:27868
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 3-Oxododecanoyl-CoA
type: Species

metaR r1851
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_72a4866b_7557_4a65_ab3a_0215416dd8eb
name: PEMT
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:10400
type: Species
is: Q9UBM1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_aac622d6_86de_4163_bb0e_cad79baa5a3b
is: P04075
name: ALDOA
initial concentration: NaN
type: Species
is encoded by: hsa:226
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_67734b83_97d8_44ea_9763_628b80760f7a
initial amount: NaN
boundary condition: true
name: FUT8
has only substance units: false
initial concentration: NaN
is: B4DFS7
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:2530

http://identifiers.org/biomodels.db/MODEL1310110046#_fb4c7b90_0a94_478d_84ae_f1fa7d32643f
is encoded by: hsa:10317
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
name: B3GALT5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_eb660b0b_a181_4921_aec3_dd3843ac6bc7
initial amount: NaN
is encoded by: hsa:2194
is: P49327
constant: false
name: FASN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_bb9df2b6_4753_4130_9b06_38ced4f44d81
is: Q6IBC4
initial concentration: NaN
initial amount: NaN
name: NDUFS6
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:4726
boundary condition: true
type: Species

metaR S6TASE26ly
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110046#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

metaR S2TASE1ly
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
name: iduronate-2-sulfatase, lysosomal
reversible: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_6125e8fb_155b_4b5f_98f3_bf7bba67eea4
is encoded by: hsa:5330
is: SBO:0000252
boundary condition: true
type: Species
name: PLCB2
constant: false
initial amount: NaN
is: Q59F77
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_e5f2cd6c_2610_44fc_98e5_c98b548e1a37
initial amount: NaN
is encoded by: hsa:57468
has only substance units: false
type: Species
initial concentration: NaN
name: SLC12A5
boundary condition: true
is: Q9H2X9
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7c18889b_8706_4d62_94d1_e51e190bb4b9
is: P46721
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6579
name: SLCO1A2
initial concentration: NaN
is: SBO:0000252

metaR ACOAD9m
is: SBO:0000176
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
product: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#

metaM leuktrC4 e
is: SBO:0000247
is: HMDB01198
initial concentration: 1.0
is: CHEBI:57973
boundary condition: false
type: Species
name: leukotriene C4(2-)
constant: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_44228c27_4bd4_49a8_ab4b_e7aa3160a1da
constant: false
name: AGMAT
is: SBO:0000252
is encoded by: hsa:79814
type: Species
has only substance units: false
is: Q9BSE5
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR URAt
name: uracil transport via facilated diffusion
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaM man r
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16024
initial amount: NaN
has only substance units: false
is: HMDB00169
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0

metaM hexdicoa r
has only substance units: false
is: C08260
boundary condition: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial amount: NaN
initial concentration: 1.0
name: hexadecanedioylcoa
constant: false
is: HMDB00672
is: SBO:0000247
type: Species

metaR DHDPBMTm
reversible: false
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.114
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: dihydroxydecaprenylbenzoate methyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
product: MODEL1310110046#
is: SBO:0000176

metaR RE2759X
is version of: http://identifiers.org/ec-code/5.1.99.4
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
reversible: true
is: SBO:0000176
fast: false
name: RE2759
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction

metaR THYMt
name: thymine reversible transport via facilated diffusion
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reactant: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
reversible: true
is: SBO:0000185

metaR FAOXTC102C101m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaM adrncoa m
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
boundary condition: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaM dolp U r
boundary condition: false
is: CHEBI:57683
name: dolichyl phosphate(2-)
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247

metaR TALA
modifier: MODEL1310110046#
name: transaldolase
is version of: http://identifiers.org/ec-code/2.2.1.2
is: SBO:0000176
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110046#
type: Reaction

metaM ksi deg37 l
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 37
is: CHEBI:16953
constant: false
is: SBO:0000247
is: HMDB00812
notes: FORMULA: C62H104N4O46 CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_f39507a4_6dd2_406e_9efb_646199924e78
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: COQ3
is encoded by: hsa:51805
is: Q9NZJ6
initial amount: NaN
type: Species
boundary condition: true

metaM xylu L c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
type: Species
constant: false
is: SBO:0000247
name: L-xylulose
is: HMDB00751
is: CHEBI:17399
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r0911
product: MODEL1310110046#
reactant: MODEL1310110046#
name: Facilitated diffusion
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185

metaR FAS100COA
fast: false
name: fatty acyl-CoA synthase (n-C10:0CoA)
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
modifier: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
is described by: ECO:0000269

metaM ocdcea r
constant: false
name: octadecenoate (n-C18:1)
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
is: CHEBI:0
boundary condition: false
is: SBO:0000247
is: HMDB00207
initial concentration: 1.0
has only substance units: false
type: Species

metaM 4abut m
is: C00334
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00112
initial amount: NaN
initial concentration: 1.0
name: 4-Aminobutanoate
has only substance units: false
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: CHEBI:16865

http://identifiers.org/biomodels.db/MODEL1310110046#_ce2d96ea_d7a6_489c_8b5e_5a5322b9b6f4
has only substance units: false
name: DMGDH
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:29958
is: B3KQ84

metaR GALSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
reversible: true
reactant: MODEL1310110046#
name: galactocerebroside intracellular transport
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false

metaM 3hexdtricoa x
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 3,7,10-hexadecatrienoylcoa

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM arachdcrn r
constant: false
name: C20:4 carnitine
initial concentration: 1.0
is: CHEBI:57368
is: HMDB06523
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM ksii core2 pre10 g
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 10
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_6bfbb478_2a56_4b48_b814_71d4df86c2a7
type: Species
constant: false
is encoded by: hsa:2987
is: Q16774
name: GUK1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM cs a deg3 l
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C31H48NO32S2 CHARGE: -3
boundary condition: false
is: HMDB00127
is: CHEBI:15748
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110046#_cb3fb13b_ba2b_48c3_9173_a13b91ceab93
has only substance units: false
initial amount: NaN
is encoded by: hsa:7358
is: O60701
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: UGDH

metaM arachdcrn x
is: HMDB06523
constant: false
is: CHEBI:57368
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0
name: C20:4 carnitine
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_e73809b1_6e6f_4495_a9a0_7f77d1529bcf
is encoded by: hsa:124
has only substance units: false
constant: false
type: Species
name: ADH1A:ADH1B
is: SBO:0000297
has part: P07327
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM xol7aone m
boundary condition: false
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
has only substance units: false
is: HMDB01993
constant: false
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
initial amount: NaN

metaR GLYt7 311 r
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
fast: false
name: glycine reversible transport via sodium and chloride symport (3:1:1)
reversible: true
type: Reaction
is described by: ECO:0000006
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_d671e485_d182_483c_804c_de81eec0bc17
name: ATP5D
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:513
initial concentration: NaN
type: Species
initial amount: NaN
is: P30049

metaM tststerone e
is: HMDB00234
constant: false
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
type: Species
is: SBO:0000247
has only substance units: false
name: testosterone
initial concentration: 1.0
is: CHEBI:17347
boundary condition: false

metaR r1637
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2112
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110046#

metaR SERt4
type: Reaction
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
kinetic law: MODEL1310110046#
fast: false
reversible: false
reactant: MODEL1310110046#
name: L-serine via sodium symport
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#

metaM ocdcea l
is: CHEBI:30823
has only substance units: false
initial amount: NaN
is: HMDB00207
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
name: oleate
is: SBO:0000247
type: Species
constant: false

metaM o2s c
is: CHEBI:18421
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02168
type: Species
has only substance units: false
name: superoxide
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false

metaR r1164
product: MODEL1310110046#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
name: EC:2.3.1.26
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reactant: MODEL1310110046#

metaM pan4p c
is: C01134
initial amount: NaN
is: CHEBI:47942
type: Species
boundary condition: false
initial concentration: 1.0
name: Pantetheine 4'-phosphate
has only substance units: false
is: HMDB01416
constant: false
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

http://identifiers.org/biomodels.db/MODEL1310110046#_158a8f8d_a551_449e_936c_cea66fd57892
is: Q16718
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: NDUFA5
is encoded by: hsa:4698
initial amount: NaN

metaR HMGCOARc
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
kinetic law: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).

metaR FAOXC121C10x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_ae248e41_79c5_40d5_bac0_8b45948b6c3a
has only substance units: false
boundary condition: true
is encoded by: hsa:506
initial amount: NaN
is: P06576
constant: false
is: SBO:0000252
name: ATP5B
initial concentration: NaN
type: Species

metaM ksi pre9 g
constant: false
initial concentration: 1.0
is: C00130
name: keratan sulfate I biosynthesis, precursor 9
initial amount: NaN
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: CHEBI:58053
boundary condition: false
is: HMDB00175
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_e0f3094f_0af4_4bb0_a889_ff6608eb1e17
boundary condition: true
is encoded by: hsa:5723
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: P78330
initial concentration: NaN
name: PSPH
has only substance units: false

metaR r2113
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000185

metaR r1638
modifier: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_d119b17d_4968_4498_95ae_f50528378d5d
type: Species
is: P43353
constant: false
name: ALDH3B1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:221
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_8dc92f05_8710_4bb5_8f1a_4bec6c08b9f0
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI378339
constant: false
type: Species
is: SBO:0000252
name: _AI378339_1_m

metaR RE2069C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000
name: RE2069
type: Reaction
is: SBO:0000176
product: MODEL1310110046#

metaR AG13T9g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110046#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reactant: MODEL1310110046#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaR r1167
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
type: Reaction
kinetic law: MODEL1310110046#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: EC:2.3.1.26
reactant: MODEL1310110046#
product: MODEL1310110046#

metaM ksii core4 pre7 g
constant: false
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 7
is: HMDB00175
boundary condition: false
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: C00130
is: SBO:0000247

metaM hdcecrn m
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
is: HMDB00222
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: Hexadecenoyl carnitine
initial concentration: 1.0

metaM pheme m
initial concentration: 1.0
is: CHEBI:17627
name: Protoheme
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB03178

metaM cs a deg1 l
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial amount: NaN
is: CHEBI:16953
type: Species
has only substance units: false
is: HMDB00812
notes: FORMULA: C45H68N2O43S2 CHARGE: -4

metaR MAN6PI
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.8
is: SBO:0000176
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000304
name: mannose-6-phosphate isomerase

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000

metaR r2114
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR GGH 6THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110046#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: Gamma-glutamyl hydrolase (6THF), extracellular
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9831a7d6_4471_4909_9468_b91f2f13b139
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:57835
has only substance units: false
name: SLC4A5

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaM pan4p e
is: CHEBI:47942
type: Species
is: HMDB01416
boundary condition: false
initial concentration: 1.0
name: Pantetheine 4'-phosphate
constant: false
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2
has only substance units: false
initial amount: NaN
is: C01134

metaR S6TASE15ly
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110046#_2cdc3043_0d5d_4503_a14f_04930d8aa990
type: Species
has only substance units: false
is: P21912
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:6390
initial concentration: NaN
initial amount: NaN
name: SDHB

metaR AHC
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.3.1.1
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: adenosylhomocysteinase

metaR S6T7g
is: SBO:0000176
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false

metaM hs deg23 l
is: HMDB02704
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
is: CHEBI:21338
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_137720a2_b884_4d99_b50a_896d44a594a6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:AI631997
name: _AI631997_1_m

metaR HMGCOASim
fast: false
modifier: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
reactant: MODEL1310110046#
product: MODEL1310110046#
name: Hydroxymethylglutaryl CoA synthase (ir)

metaR 4MOPt2im
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
product: MODEL1310110046#

metaR r2115
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000

metaM val L m
is: HMDB00883
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
is: CHEBI:16414
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: L-valine

metaR r0809
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110046#
type: Reaction
name: Facilitated diffusion
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_f0836e10_edeb_4515_8e71_e44b1ec96326
name: NDUFB5
is encoded by: hsa:4711
has only substance units: false
initial amount: NaN
is: O43674
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_52c8d75a_8d2a_48b3_95e8_446649bdc812
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GART
initial concentration: NaN
constant: false
is: Q59HH3
is encoded by: hsa:2618
boundary condition: true

metaR ANTHte
is described by: ECO:0000134
fast: false
name: Transport of anthranilate
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR PMANM
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/5.4.2.8
is: SBO:0000176
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.4.2.2
name: phosphomannomutase
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#

metaM acgal1p c
name: N-Acetyl-D-galactosamine 1-phosphate
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
type: Species
initial concentration: 1.0
is: HMDB06480
initial amount: NaN
has only substance units: false
is: CHEBI:55404

metaR FACOAL246 1
modifier: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
is: SBO:0000176
reversible: true
product: MODEL1310110046#
fast: false

metaR ASPGLUm
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110046#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110046#
modifier: MODEL1310110046#
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_96be213f_f712_4317_b6db_ca33e5dda292
boundary condition: true
initial amount: NaN
name: ALDOB
is encoded by: hsa:229
is: SBO:0000252
has only substance units: false
is: P05062
type: Species
constant: false
initial concentration: NaN

metaR r2411
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110046#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185

metaR LNLNCACRNt
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110046#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110046#
fast: false
product: MODEL1310110046#

metaR S23T2g
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110046#
is described by: ECO:0000000
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
fast: false

metaR r2116
modifier: MODEL1310110046#
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_50b9bfe1_10d5_4503_a7e2_43b327684300
is encoded by: hsa:AA526438
initial amount: NaN
has only substance units: false
constant: false
name: _AA526438_1_m
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM 4abut c
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00112
name: 4-Aminobutanoate
is: CHEBI:3628
has only substance units: false
is: C00334

http://identifiers.org/biomodels.db/MODEL1310110046#_c9fbeaf8_1bff_4ce8_af53_76fc6f9f3aa0
has only substance units: false
is encoded by: hsa:7084
boundary condition: true
constant: false
is: O00142
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: TK2

http://identifiers.org/biomodels.db/MODEL1310110046#_cc117156_93fd_4507_b0d5_c4ff542def5f
is: Q76EJ3
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:11046
is: SBO:0000252
name: SLC35D2
initial concentration: NaN
has only substance units: false

metaM pydx e
initial concentration: 1.0
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: CHEBI:17310
type: Species
name: Pyridoxal
boundary condition: false
is: C00250
is: SBO:0000247
is: HMDB01545
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_da07cc5e_7cfd_45fa_8dbf_8f9349164286
is encoded by: hsa:26
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: P19801
name: ABP1
is: SBO:0000252

metaR ALAGLNNaEx
reversible: false
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR r1633
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110046#
reversible: true
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_6ff95601_be4e_4c56_a3c7_fe2fd679bf21
initial concentration: NaN
name: IMPA1
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3612
is: B7Z6Q4
type: Species
is: SBO:0000252
initial amount: NaN

metaR r2117
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
reversible: true
reactant: MODEL1310110046#

metaM 6pgc r
has only substance units: false
is: HMDB01316
is: SBO:0000247
name: 6-phosphonatooxy-D-gluconate
initial amount: NaN
type: Species
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
initial concentration: 1.0
boundary condition: false
is: CHEBI:58759
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f24c6c92_aabc_49bb_ade6_7b1b21f3ce62
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:2271
initial concentration: NaN
is: SBO:0000252
type: Species
is: P07954
name: FH

metaM m2gacpail hs r
is: CHEBI:16038
initial concentration: 1.0
type: Species
boundary condition: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
initial amount: NaN
constant: false
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: SBO:0000247

metaM adrncoa x
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: adrenyl coenzyme A
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/47205480

http://identifiers.org/biomodels.db/MODEL1310110046#_2adb7b67_d231_4cee_b321_557a441a043f
is: E7EPA7
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: TKT
is encoded by: hsa:7086
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_64259a0e_b406_4530_a3c8_5ce9c594b8fb
constant: false
initial amount: NaN
is: B5MCC7
is: SBO:0000252
has only substance units: false
name: ACP1
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:52

http://identifiers.org/biomodels.db/MODEL1310110046#_1561b89b_7a7f_48e8_af50_b8d20f9eb84e
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:C7orf24
name: _C7orf24_1_m

metaM 4hexdtetcoa m
initial amount: NaN
initial concentration: 1.0
is: HMDB02288
constant: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 4,7,10,13-hexadecatetraenoylcoa

metaM pydx5p c
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
type: Species
has only substance units: false
is: C00018
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01491
initial concentration: 1.0
is: SBO:0000247
name: Pyridoxal 5'-phosphate
is: CHEBI:597326

metaR r1634
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR URCN
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.2.1.49
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110046#
type: Reaction
fast: false
reversible: false
is: SBO:0000176
name: URCN
reactant: MODEL1310110046#

metaR RE3245C
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is: SBO:0000176
kinetic law: MODEL1310110046#
fast: false
name: RE3245
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000

metaR r2118
reactant: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_3db9d46b_b540_4de3_8450_6d0a84c9c249
initial amount: NaN
has only substance units: false
name: ACSS2
is encoded by: hsa:55902
boundary condition: true
type: Species
is: Q5QPH3
is: SBO:0000252
constant: false
initial concentration: NaN

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

metaR ALAt2r
reversible: true
product: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-alanine reversible transport via proton symport
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_985507e1_dc54_47a1_a66a_f0cac33fefdb
boundary condition: true
initial amount: NaN
is encoded by: hsa:28976
name: ACAD9
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q9H845

metaR r1635
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
type: Reaction
reversible: true
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_aeaa60e0_b177_45a7_ae0a_f4b8467c1a66
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4726
name: NDUFS6
type: Species
is: Q6IBC4
constant: false

metaM tststerone c
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
is: SBO:0000247
name: testosterone
boundary condition: false
type: Species
is: CHEBI:17347
is: HMDB00234

metaM 4abut e
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00112
is: CHEBI:3628
initial concentration: 1.0
is: C00334
name: 4-Aminobutanoate

metaR r2119
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000

metaR HDCAtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000

metaR PRISTCOAtcx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM thym c
is: HMDB00262
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: Thymine
is: C00178
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: CHEBI:17821
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_c7cec8a7_9913_4408_b388_3b8ab267ef19
boundary condition: true
type: Species
is encoded by: hsa:10317
initial concentration: NaN
constant: false
name: B3GALT5
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR FAOXC183C163m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)m
type: Reaction

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaM pydx5p e
is: HMDB01491
initial amount: NaN
boundary condition: false
name: pyridoxal 5'-phosphate(2-)
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
type: Species
initial concentration: 1.0
is: CHEBI:597326
has only substance units: false
constant: false
is: SBO:0000247

metaM fum m
has only substance units: false
is: CHEBI:29806
type: Species
is: C00122
initial concentration: 1.0
is: HMDB00134
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: SBO:0000247
initial amount: NaN
name: Fumarate
constant: false
boundary condition: false

metaR FATP1t
name: fatty acid electroneutral transport
reversible: true
type: Reaction
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9b6b26e1_05ca_40f3_89c5_4be6c305b339
constant: false
has only substance units: false
is encoded by: hsa:AU149534
name: _AU149534_1_e
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR r1636
fast: false
type: Reaction
reactant: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#

metaR LNLCCRNt
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9fcaf045_11bb_470d_b04d_e16afdcacf9f
boundary condition: true
type: Species
constant: false
name: LDHA
is encoded by: hsa:3939
initial amount: NaN
is: P00338
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_3709c8dc_0ddd_4146_b927_a8cafe6452f5
constant: false
has only substance units: false
is: P50747
boundary condition: true
is encoded by: hsa:3141
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: HLCS

metaR r0909
kinetic law: MODEL1310110046#
name: Transport reaction
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_6c2a6a39_3035_410b_bde7_b63d8c9a856e
name: PMVK
is: SBO:0000252
boundary condition: true
is: Q6FGV9
initial amount: NaN
is encoded by: hsa:10654
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaR KSIt
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110046#
type: Reaction
name: keratan sulfate I transport, golgi to extracellular
reversible: false

metaR r2520
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
kinetic law: MODEL1310110046#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110046#

metaM ocdcea c
is: C00712
initial concentration: 1.0
is: CHEBI:0
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00207
name: octadecenoate (n-C18:1)

metaM HC02202 e
type: Species
has only substance units: false
is: CHEBI:57398
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
initial amount: NaN
name: prostaglandin A1(1-)
initial concentration: 1.0

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM ksii core2 pre8 g
boundary condition: false
is: C00130
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
constant: false
is: HMDB00175
type: Species
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 8
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2

metaR NDPK10n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
reversible: true
is: SBO:0000176
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_b17d9eda_ee75_4daf_baa2_cad73ac404a0
has only substance units: false
boundary condition: true
name: DGKQ
is: P52824
constant: false
type: Species
is encoded by: hsa:1609
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR CLPNDCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
type: Reaction
is described by: ECO:0000000
name: fatty acid intracellular transport
is: SBO:0000185

metaM ksi deg34 l
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 34
is: CHEBI:16953
constant: false
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
boundary condition: false
is: SBO:0000247
is: HMDB00812
initial amount: NaN

metaR ACGPID
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
kinetic law: MODEL1310110046#
type: Reaction
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is described by: ECO:0000269
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.5.1.89
reversible: false
fast: false
is: SBO:0000176

metaM man c
initial amount: NaN
is: CHEBI:16024
has only substance units: false
type: Species
is: HMDB00169
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
is: SBO:0000247
is: C00159
initial concentration: 1.0
name: D-Mannose

metaR r0908
reversible: true
is described by: ECO:0000000
fast: false
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_a058d3c7_c915_4e9d_bb80_a5ab261a0611
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:AV717590
is: SBO:0000252
initial concentration: NaN
name: _AV717590_1_m
has only substance units: false
constant: false

metaR r2521
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
name: Utilized transport
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
is: SBO:0000185
fast: false

metaR TETTET6COAtx
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: fatty acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction

metaM ins e
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
is: SBO:0000247
is: HMDB00195
is: C00294
type: Species
initial amount: NaN
constant: false
is: CHEBI:17596
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r1630
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_547f1dca_d9b0_499f_8fca_626ba53710c9
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:64064
has only substance units: false
name: OXCT2
is: Q9BYC2

metaR r1051
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110046#
reversible: true
is: SBO:0000185
product: MODEL1310110046#
type: Reaction
name: Vesicular transport
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR NACHEX24ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
fast: false
reversible: false

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM hx2coa x
constant: false
is: C00888
is: SBO:0000247
initial concentration: 1.0
name: trans-Hex-2-enoyl-CoA
boundary condition: false
has only substance units: false
is: HMDB13037
initial amount: NaN
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR PCHOLP hs
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
product: MODEL1310110046#
name: choline phosphatase
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000269

metaM ocdcea e
name: octadecenoate (n-C18:1)
initial amount: NaN
is: CHEBI:0
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00207
has only substance units: false
is: C00712

metaR r1631
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
reversible: true

metaR SIAT4Bg
reversible: false
kinetic law: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reactant: MODEL1310110046#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.99.4

http://identifiers.org/biomodels.db/MODEL1310110046#_8e421ff8_0f36_4036_a02e_6e5eebd14ea8
initial concentration: NaN
boundary condition: true
name: ACLY
is encoded by: hsa:47
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: P53396
is: SBO:0000252

metaM HC00900 m
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
name: Methylmalonate
initial amount: NaN
is: CHEBI:30860
boundary condition: false
is: SBO:0000247

metaR DURAD2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
name: dihydrothymin dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is: SBO:0000176
reactant: MODEL1310110046#
fast: false
reversible: true
product: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#

metaM dolmanp L r
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
is: CHEBI:15809
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247

metaR r0801
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
modifier: MODEL1310110046#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM occoa m
initial amount: NaN
is: CHEBI:57386
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: C01944
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01070
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)
type: Species

metaR UMPK
fast: false
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
name: UMP kinase
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110046#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110046#
is described by: ECO:0000269

metaM man e
is: C00159
is: HMDB00169
boundary condition: false
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR G16MT L
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)

metaR UAG2EMAi
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/5.1.3.14
fast: false
reversible: false
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaR DOLPH Ler
name: Dolichol-phosphate phosphohydrolase, human (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_0ccec9e0_66ef_4dbf_8b27_4655c9d17c0c
constant: false
initial concentration: NaN
is encoded by: hsa:5152
has only substance units: false
name: PDE9A
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaM c226crn m
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/127055
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: cervonyl carnitine
is: HMDB06510

metaM f6p c
is: CHEBI:57579
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3385
type: Species
is: HMDB00124
boundary condition: false
name: D-Fructose 6-phosphate
has only substance units: false
initial amount: NaN
is: C00085
initial concentration: 1.0

metaR LNELDCt
kinetic law: MODEL1310110046#
name: fatty acid transport via diffusion
reversible: true
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110046#
type: Reaction

metaM pheme c
initial amount: NaN
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: HMDB03178
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Protoheme
is: CHEBI:17627
initial concentration: 1.0
is: C00032
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7b497e8e_a2fa_4519_871b_9b28ef107cc8
is: SBO:0000252
is encoded by: hsa:10400
initial amount: NaN
has only substance units: false
name: PEMT
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaM gpi sig r
initial concentration: 1.0
notes: FORMULA: Y CHARGE: 0
is: HMDB00224
has only substance units: false
boundary condition: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
type: Species
is: CHEBI:58190
initial amount: NaN
constant: false
is: SBO:0000247

metaR r1632
kinetic law: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110046#
type: Reaction
fast: false
reactant: MODEL1310110046#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
is described by: ECO:0000000

metaM dem2emgacpail prot hs r
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
is: CHEBI:53486
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB02925

metaM andrstndn r
is: HMDB00053
name: androst-4-ene-3,17-dione
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16422

metaR r2419
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_c3f86599_8c86_4ab8_98e6_fd7a1211b8d3
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4536
initial amount: NaN
name: ND2
is: SBO:0000252
constant: false
is: Q7GXY9

http://identifiers.org/biomodels.db/MODEL1310110046#_46d53236_d36c_4841_91bb_c1fe8483282a
constant: false
type: Species
boundary condition: true
is: P05166
name: PCCB
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5096
initial concentration: NaN
initial amount: NaN

metaM xol7aone r
name: 7alpha-hydroxycholest-4-en-3-one
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01993
initial amount: NaN
type: Species
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
boundary condition: false
has only substance units: false
is: CHEBI:17899

metaR RE2626C
name: RE2626
fast: false
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110046#

metaR r0093
fast: false
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
is version of: http://identifiers.org/ec-code/3.5.1.3
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaM m4mpdol L r
is: CHEBI:37633
constant: false
has only substance units: false
boundary condition: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR CHOLt4
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
fast: false
name: choline, sodium cotransport

http://identifiers.org/biomodels.db/MODEL1310110046#_560d3651_7909_4a14_9ec9_83f0c49d0924
is: Q8N370
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC43A2
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:124935

metaM hs deg11 l
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: heparan sulfate, degradation product 11
initial concentration: 1.0
is: HMDB00868
has only substance units: false
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110046#_60a4b354_bec9_4548_8c1b_a9446106a2dd
is: Q13615
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:8897
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: MTMR3

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
reversible: true

metaM 3php c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18110
has only substance units: false
boundary condition: false
name: 3-phosphonatooxypyruvate(3-)
constant: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
type: Species
is: HMDB01024
is: SBO:0000247

metaR OIVD3m
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
reactant: MODEL1310110046#
is: SBO:0000176
type: Reaction
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.168
is version of: http://identifiers.org/ec-code/1.2.4.4
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f6decce6_6b89_4e6d_941c_ef28dcdbe8fa
is: Q8N4Q0
boundary condition: true
constant: false
is encoded by: hsa:284273
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: ZADH2
has only substance units: false

metaM HC02187 e
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
name: reverse-triiodthyronine
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_de59f0fa_b834_43e6_aab5_aa22ebd27499
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: B3GNT8
initial concentration: NaN
is encoded by: hsa:374907

http://identifiers.org/biomodels.db/MODEL1310110046#_42998e80_9feb_467a_b136_c2f030f1279d
boundary condition: true
is: SBO:0000252
constant: false
name: ALDH3B2
type: Species
has only substance units: false
is: P48448
is encoded by: hsa:222
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_3da6e2a3_c3ba_46e7_8955_3137d04bb908
is: SBO:0000252
name: SLC7A8
initial amount: NaN
boundary condition: true
is encoded by: hsa:23428
has only substance units: false
is: Q86U05
constant: false
type: Species
initial concentration: NaN

metaR RE1516M
product: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1516
is: SBO:0000176
reactant: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_b998baed_cc2c_40d3_92b7_b49b21d4c221
initial amount: NaN
boundary condition: true
is: A5JJ20
is encoded by: hsa:8671
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: SLC4A4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_9cd9759a_aa4c_475b_a8e9_fccf5ec039f9
is: Q9BY49
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: PECR
initial amount: NaN
is encoded by: hsa:55825

http://identifiers.org/biomodels.db/MODEL1310110046#_b74f00aa_c7fb_4f7e_b927_09ad148a1f8f
boundary condition: true
constant: false
name: ADA
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: P00813
is encoded by: hsa:100

metaM hs deg20 l
has only substance units: false
is: CHEBI:16126
is: SBO:0000247
name: heparan sulfate, degradation product 20
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial amount: NaN
constant: false

metaR r2526
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110046#
type: Reaction

metaR r2110
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000

metaM g3pc c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
constant: false
is: HMDB00086
boundary condition: false
is: CHEBI:16870
initial amount: NaN
name: sn-Glycero-3-phosphocholine
type: Species

metaR r2111
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
reactant: MODEL1310110046#

metaM HC02187 c
initial concentration: 1.0
boundary condition: false
is: CHEBI:28774
name: reverse-triiodthyronine
is: SBO:0000247
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1391b166_8add_4122_8a23_6a7a527b7132
is: A8K3L7
constant: false
boundary condition: true
name: CDIPT
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10423
initial amount: NaN
initial concentration: NaN

metaR PAFHe
modifier: MODEL1310110046#
is described by: ECO:0000269
fast: false
name: Platelet-activating factor acetylhydrolase
is version of: http://identifiers.org/ec-code/3.1.1.47
kinetic law: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
reactant: MODEL1310110046#
reversible: false
type: Reaction

metaM ins c
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17596
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
constant: false
is: C00294
is: HMDB00195
name: Inosine

metaR SUCCtp
reactant: MODEL1310110046#
name: succinate transporter, peroxisome
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
type: Reaction

metaR FORMCOAtx
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
name: formyl coa transport
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#

metaM tmndnccrn c
is: CHEBI:0
has only substance units: false
type: Species
is: C00378
is: SBO:0000247
boundary condition: false
name: Timnodonyl carnitine
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00235
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110046#_43b57335_0b35_4319_866f_12c3aad0e00e
name: ST3GAL3
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:6487

metaR TRDRm
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: thioredoxin reductase (NADPH)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD

metaR r1487
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
fast: false
name: EC:6.2.1.3
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_c7132369_ae3b_4e19_ad52_ccf2caa722ab
constant: false
is: SBO:0000252
is: Q99999
has only substance units: false
boundary condition: true
is encoded by: hsa:9514
initial concentration: NaN
type: Species
name: GAL3ST1
initial amount: NaN

metaR r0281
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
reactant: MODEL1310110046#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction
modifier: MODEL1310110046#

metaR r0084
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110046#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
modifier: MODEL1310110046#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaM 3mob e
type: Species
initial amount: NaN
name: 3-methyl-2-oxobutanoate
boundary condition: false
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial concentration: 1.0
is: CHEBI:11851
has only substance units: false
is: SBO:0000247
constant: false

metaR NRPPHRSFt
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
is described by: ECO:0000000
fast: false
name: norepinephrine sulfate transport (diffusion)
reactant: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaR r0394
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is: SBO:0000176
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is described by: ECO:0000000
reversible: true
product: MODEL1310110046#

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM ksii core4 pre8 g
notes: FORMULA: C83H134N7O61SX CHARGE: -2
constant: false
is: C00130
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00175
has only substance units: false
is: CHEBI:58053
is: SBO:0000247
type: Species
name: keratan sulfate II biosynthesis, precursor 8

metaM ksi pre32 g
type: Species
name: keratan sulfate I biosynthesis, precursor 32
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
boundary condition: false
constant: false
is: CHEBI:28067
is: SBO:0000247

metaM ksi deg29 l
initial amount: NaN
name: keratan sulfate I, degradation product 29
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00143
has only substance units: false
type: Species
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
initial concentration: 1.0

metaR UMPK4
is described by: ECO:0000269
fast: false
reactant: MODEL1310110046#
name: UMP kinase (GTP)
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110046#

metaR 3MOX4HOXPGALDOX NADP
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
reactant: MODEL1310110046#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase

metaM 5adtststerones c
boundary condition: false
constant: false
is: HMDB06278
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR AHEXASEly
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_aacc6cda_5024_43bc_ba8f_6787f73431ac
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5321
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: P47712
name: PLA2G4A

metaM cgly e
is: CHEBI:4047
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial amount: NaN
initial concentration: 1.0
is: HMDB00078
has only substance units: false
boundary condition: false
type: Species
name: L-cysteinylglycine
is: SBO:0000247

metaR UGALGTg
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110046#
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000134
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: false

metaM c10dc e
has only substance units: false
notes: FORMULA: C17H30NO6 CHARGE: -1
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB04047
is: C14143
name: sebacoyl carnitine
initial amount: NaN

metaR r0083
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110046#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_01926399_48d9_409c_8761_fb1d85d5a99e
name: _AI824319_1_r
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI824319
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_21db6677_49a4_4b8e_b7b2_53c2aa32284f
initial concentration: NaN
name: CHAT
type: Species
is encoded by: hsa:1103
is: SBO:0000252
is: P28329
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaM ahdt e
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00980
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
initial amount: NaN
is: CHEBI:58462
type: Species

metaR FAOXTC122m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaR MCLACCYSR
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
fast: false
name: 3-mercaptolactate:cysteine reductase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_650d8705_645e_4c3a_bb68_e9659a9456ae
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:204
is: SBO:0000252
name: AK2
initial concentration: NaN

metaR LEULEULAPc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR MANter
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reversible: false
name: mannose efflux from endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110046#
type: Reaction

metaR UMPK5
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110046#
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP)

http://identifiers.org/biomodels.db/MODEL1310110046#_7c04ea8d_6e11_428a_b0d0_2215bd365f7b
constant: false
is: O14832
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5264
name: PHYH
type: Species
has only substance units: false

metaM thcholstoic c
initial concentration: 1.0
is: HMDB03873
is: CHEBI:18402
initial amount: NaN
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
boundary condition: false

metaM octdececoa m
constant: false
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
initial amount: NaN
type: Species
name: octadecenoylcoa
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_ec902295_d4af_4a8d_a3e3_e671da0389f0
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC4A5
constant: false
is encoded by: hsa:57835
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_607ac301_e0ab_4898_be7a_71e0dba6a91b
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: ST3GAL1
initial concentration: NaN
is: Q11201
initial amount: NaN
is encoded by: hsa:6482

http://identifiers.org/biomodels.db/MODEL1310110046#_c89e5a56_c5bc_4b66_bbf9_a58e20681c32
boundary condition: true
is: Q53G02
has only substance units: false
is encoded by: hsa:1603
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: DAD1
constant: false

metaR PROSTGF2t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
product: MODEL1310110046#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
modifier: MODEL1310110046#
name: prostaglandin uniport
reactant: MODEL1310110046#

metaR NACASPAH
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.5.1.15
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
reversible: false
type: Reaction
name: N-Acetyl-L-aspartate amidohydrolase
is described by: ECO:0000269

metaR RE2814M
is described by: ECO:0000000
reversible: true
fast: false
name: RE2814
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#

metaR DMGtm
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
name: dimethylglycine transport via diffusion (cytosol to mitochondria)
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_c7e328ff_a20a_4938_b97d_a2930a693dd3
initial concentration: NaN
is: Q2TU34
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:2203
has only substance units: false
is: SBO:0000252
name: FBP1

metaR C160CPT2
product: MODEL1310110046#
name: C160 transport into the mitochondria
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000269
reversible: false

metaR r0086
fast: false
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction

metaR H2O2tp
kinetic law: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
fast: false
name: hydrogen peroxide peroxisomal transport via diffusion
reactant: MODEL1310110046#
is: SBO:0000185
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000

metaR UGCG
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.80
reversible: false
modifier: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
name: Ceramide glucosyltransferase
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ

metaM ksi pre18 g
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58053
is: SBO:0000247
type: Species
initial amount: NaN
is: C00130
name: keratan sulfate I biosynthesis, precursor 18
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: HMDB00175

metaR CDSm
reversible: false
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
is: SBO:0000176
name: phosphatidate cytidylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

metaR FADtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: FAD transporter, peroxisomal
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR BTND1
is: SBO:0000176
name: biotinidase (biotin)
reversible: false
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110046#
fast: false

metaR MEVK1c
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.36
is described by: ECO:0000134
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is: SBO:0000176
type: Reaction
name: mevalonate kinase (atp) cytosol
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_2a3157b5_a431_4da5_abc3_3254ea0c1614
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:23236
name: PLCB1
type: Species

metaR UMPK6
product: MODEL1310110046#
type: Reaction
name: UMP kinase (dCTP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_c01ad528_fceb_404c_a6b4_c0369705435f
is encoded by: hsa:10449
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: ACAA2
constant: false
is: P42765

metaR OAGT3tg
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185
type: Reaction
name: oagt3 hs intracellular transport
reversible: true
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_bc42729d_74a1_44d4_bbb7_44df471bf1ba
is: SBO:0000252
has only substance units: false
is: P07203
name: GPX1
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:2876

metaR OAGT3te
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000000
name: oagt3 hs transport
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_ef6cd55c_5886_4d50_9161_b875f311124f
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: P14060
name: HSD3B1
initial concentration: NaN
is encoded by: hsa:3283

metaR TAURt4 2 r
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: taurine transport (sodium symport) (2:1)
reversible: true
is: SBO:0000185

metaM c10dc c
notes: FORMULA: C17H30NO6 CHARGE: -1
initial concentration: 1.0
type: Species
is: SBO:0000247
name: sebacoyl carnitine
boundary condition: false
is: C14143
constant: false
is: HMDB04047
has only substance units: false
initial amount: NaN

metaR 34HPPOR
is described by: ECO:0000269
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.13.11.27
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
reversible: false
modifier: MODEL1310110046#
product: MODEL1310110046#
fast: false
is: SBO:0000176

metaR G14T2g
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reactant: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110046#_5b364ce9_1974_40ec_b108_2da97255d98d
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ATP1A4
is encoded by: hsa:480
has only substance units: false
is: Q13733
constant: false
type: Species
is: SBO:0000252

metaM fum c
is: HMDB00134
is: SBO:0000247
has only substance units: false
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
boundary condition: false
is: CHEBI:29806
initial amount: NaN
is: C00122
initial concentration: 1.0
constant: false

metaR DGULND
reversible: true
fast: false
name: dehydro-L-gulonate decarboxylase
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110046#

metaM fad m
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16238
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
initial amount: NaN
has only substance units: false
name: Flavin adenine dinucleotide oxidized
type: Species

metaR KYNAKGAT
type: Reaction
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: L-Kynurenine:2-oxoglutarate aminotransferase
fast: false
reversible: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB

metaR r0085
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM 5dpmev c
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01090
initial concentration: 1.0
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
has only substance units: false
type: Species
constant: false
name: (R)-5-Diphosphomevalonate

metaM 2decdicoa m
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
name: 2,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966

metaR FCOAH
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
product: MODEL1310110046#
type: Reaction
name: formyl coa hydrolase
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
reversible: false

metaR UMPK7
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: UMP kinase (dGTP)

http://identifiers.org/biomodels.db/MODEL1310110046#_8470958a_9ef4_4135_b809_456bd9c01fbb
boundary condition: true
type: Species
is: Q9NY65
name: EHHADH
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1962
initial amount: NaN

metaM 3aib D c
is: C03265
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: HMDB02299
name: D-3-Amino-isobutanoate

metaR AG13T17g
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_6c5f8312_2154_4b11_9ea0_7426e020d8a8
name: DGKZ
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: B7Z6M3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8525

metaM hx2coa m
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
has only substance units: false
name: trans-Hex-2-enoyl-CoA
initial amount: NaN
boundary condition: false
type: Species
is: HMDB13037
is: C00888

metaR H2O2tn
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
name: hydrogen peroxide nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110046#_a3369fe3_19bf_4030_b05d_e74f11f43a85
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _R06874_1_r
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:R06874

metaM fuc L c
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: L-fucose
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: HMDB00174
is: CHEBI:18287
has only substance units: false

metaM pail5p hs c
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
constant: false

metaM cs a deg4 l
initial amount: NaN
notes: FORMULA: C31H49NO29S CHARGE: -2
is: CHEBI:16953
has only substance units: false
type: Species
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00812

http://identifiers.org/biomodels.db/MODEL1310110046#_a3cbf411_7299_4a70_a42d_6c8e342abdf9
is: P04745
initial concentration: NaN
name: AMY1B
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:277
initial amount: NaN

metaR PHACCOAGLNAC
is: SBO:0000176
reactant: MODEL1310110046#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000000
fast: false
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaR ACNAM9PL
reactant: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.56
fast: false
product: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_37c393ec_1ca3_46a7_b764_924795239073
type: Species
is: Q6P1K9
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80025
constant: false
boundary condition: true
initial amount: NaN
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110046#_98ccfef7_7989_4f4d_97f2_90a4eed20d9c
is: Q5JZF5
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:212
name: ALAS2
constant: false
initial concentration: NaN
initial amount: NaN

metaR DNDPt29m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
name: dCDP transport via dADP antiport
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000185
fast: false
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_85028e79_b97f_485d_99ca_3d4aa6892ee4
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:7371
initial amount: NaN
is: Q9BZX2
constant: false
boundary condition: true
has only substance units: false
name: UCK2

metaM o2s m
type: Species
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB02168
boundary condition: false
name: Superoxide anion
is: C00704
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_50919cf4_6372_44fa_9c43_bd003aa6a580
has only substance units: false
is encoded by: hsa:8140
initial amount: NaN
name: SLC7A5
is: Q8IV97
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR PYDXNK
is described by: ECO:0000269
name: pyridoxine kinase
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.35
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false

metaR GALASE5ly
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110046#_6ef18869_ea8f_4451_920a_a617fe589f16
is encoded by: hsa:1635
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: DCTD
initial amount: NaN
is: P32321
boundary condition: true
is: SBO:0000252

metaR NaKt
is version of: http://identifiers.org/ec-code/3.6.3.9
kinetic law: MODEL1310110046#
reversible: false
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
product: MODEL1310110046#
name: Na+/K+ exchanging ATPase
is described by: ECO:0000269

metaM ha pre1 l
constant: false
type: Species
boundary condition: false
is: CHEBI:16126
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1

metaR r0399
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
type: Reaction
modifier: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_6422bc8c_eb06_45cd_95b9_48356d0a81df
type: Species
is: SBO:0000252
is: E7EQF2
name: CROT
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54677
initial amount: NaN
constant: false
boundary condition: true

metaR SIAASEly
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reversible: false
is: SBO:0000176
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110046#

metaM 5mta c
has only substance units: false
initial concentration: 1.0
type: Species
is: C00170
initial amount: NaN
boundary condition: false
is: CHEBI:17509
is: SBO:0000247
name: 5-Methylthioadenosine
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: HMDB01173
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_ec02f278_3ed9_4aa8_b0bd_28a96b56d7e8
is encoded by: hsa:2629
type: Species
name: GBA
initial amount: NaN
is: P04062
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM 34dhpac c
is: CHEBI:27978
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
is: SBO:0000247
is: HMDB03791
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 3,4-Dihydroxyphenylacetaldehyde
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_21de3265_4122_472d_a0a9_d6ae8b9e65ac
initial amount: NaN
is: P36957
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:1743
is: SBO:0000252
name: DLST
type: Species

metaR HS1ly
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.10.1.1
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
product: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
kinetic law: MODEL1310110046#

metaM nh4 e
boundary condition: false
name: ammonium
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
initial amount: NaN
constant: false
is: CHEBI:28938

metaR S3TASE3ly
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
type: Reaction
name: N-acetylglucosamine-3-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR r0907
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
name: Active transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaM CE2432 m
is: SBO:0000247
initial amount: NaN
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
type: Species
constant: false
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
has only substance units: false
initial concentration: 1.0
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110046#_54f3a471_3706_4bc9_a416_c65139ddf273
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AI091231
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AI091231_1_c

http://identifiers.org/biomodels.db/MODEL1310110046#_42e0f87c_d438_41f9_b273_1ecaf96e60d9
name: PI4KA
initial amount: NaN
is encoded by: hsa:5297
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: B4DYG5
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_36cded55_8755_4611_a078_2ad5c6dea307
is: SBO:0000252
is: O95340
is encoded by: hsa:9060
constant: false
initial concentration: NaN
name: PAPSS2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaM fuc L e
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00174
name: L-fucose
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247
constant: false
has only substance units: false

metaR r1590
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110046#
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_a77a27aa_3397_4984_9d45_388da20da87b
name: HGD
is: Q93099
is encoded by: hsa:3081
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaM hexe3coa x
has only substance units: false
type: Species
name: 3-hexenoylcoa
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06522
initial concentration: 1.0

metaM 3mob c
has only substance units: false
is: CHEBI:11851
initial concentration: 1.0
initial amount: NaN
name: 3-methyl-2-oxobutanoate
boundary condition: false
is: SBO:0000247
is: HMDB00019
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_6ae2ac54_c00b_42bf_9f13_0794d9164fce
name: ECI1
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1632
initial concentration: NaN
is: P42126
constant: false
initial amount: NaN

metaR FAOXC163Gm
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR 35CGMPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#
name: 35cGMP nuclear transport
product: MODEL1310110046#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
type: Reaction
name: Beta oxidation fatty acid
fast: false
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176

metaM HC01104 e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 4-nitrophenyl phosphate(2-)
initial amount: NaN
type: Species
is: CHEBI:61146
boundary condition: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d5ee493e_61a4_41b9_87c8_8555628a7154
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC4A1
constant: false
is: P02730
is encoded by: hsa:6521
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_bb1ab9f3_120b_44a3_9642_2c0890cbd9ab
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: _J03866_1_m
is encoded by: hsa:J03866
boundary condition: true

metaM pyr e
is: SBO:0000247
is: HMDB00243
is: CHEBI:15361
name: pyruvate
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_f45579bd_180d_4c82_883a_48ad4eac2646
is encoded by: hsa:8875
constant: false
initial concentration: NaN
is encoded by: hsa:55350
is: SBO:0000297
initial amount: NaN
name: VNN3:VNN2:VNN1
has only substance units: false
has part: O95498
boundary condition: true
type: Species

metaM 5mta e
is: SBO:0000247
initial concentration: 1.0
is: C00170
boundary condition: false
constant: false
notes: FORMULA: C11H15N5O3S CHARGE: 0
initial amount: NaN
type: Species
is: CHEBI:17509
has only substance units: false
name: 5-Methylthioadenosine
is: HMDB01173

metaR r1591
reactant: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000185

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_03e95478_757d_4efa_b093_39814d46a21f
initial concentration: NaN
name: LSS
constant: false
is encoded by: hsa:4047
initial amount: NaN
is: E9PEI9
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR RE2814R
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
fast: false

metaR RE2649C
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
name: RE2649
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110046#
type: Reaction

metaR D3AIBTm
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
type: Reaction
product: MODEL1310110046#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110046#_cf8503ca_6395_4d0f_af41_77a3860c3e2f
is: O43865
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:10768
constant: false
initial amount: NaN
initial concentration: NaN
name: AHCYL1
is: SBO:0000252

metaM nh4 c
is: CHEBI:28938
initial amount: NaN
has only substance units: false
is: C01342
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
name: Ammonium
is: HMDB00051

metaM dcsptn1coa x
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
constant: false
is: HMDB06513
initial amount: NaN
type: Species
has only substance units: false
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0

metaM 2hb e
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
type: Species
is: CHEBI:1148
is: HMDB00008
constant: false
initial concentration: 1.0
boundary condition: false
name: 2-Hydroxybutyrate
is: SBO:0000247

metaM o2s n
initial amount: NaN
has only substance units: false
constant: false
name: superoxide
is: SBO:0000247
initial concentration: 1.0
is: HMDB02168
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_2b561375_a8cc_49e9_aa9e_f64a5bbd4d0b
initial amount: NaN
is encoded by: hsa:10449
is: P42765
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ACAA2
type: Species

metaR CYSSNAT5tc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR ALAASNNaEx
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_92ea46d1_d9de_43d9_b8e6_98f90ceaf517
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3028
initial amount: NaN
has only substance units: false
is: Q99714
name: HSD17B10
initial concentration: NaN
is: SBO:0000252

metaM pan4p m
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
name: pantetheine 4'-phosphate(2-)
has only substance units: false
constant: false
is: HMDB01416
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:47942

http://identifiers.org/biomodels.db/MODEL1310110046#_82f90fe8_bf33_408a_9376_f6ca62ea61fb
type: Species
is encoded by: hsa:2222
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: P37268
constant: false
name: FDFT1
initial concentration: NaN

metaR r1592
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
fast: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_49d784a8_5313_4add_9e02_093279e706bc
is encoded by: hsa:5407
has only substance units: false
constant: false
is: P54315
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PNLIPRP1
type: Species

metaR SERGLNexR
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: L-Serine/Glutamine reversible exchange
is described by: ECO:0000304
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110046#

metaM pydx c
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
has only substance units: false
constant: false
is: C00250
boundary condition: false
initial amount: NaN
name: Pyridoxal
is: CHEBI:17310
is: HMDB01545
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM 2hb c
initial amount: NaN
is: HMDB00008
boundary condition: false
is: CHEBI:1148
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
has only substance units: false
name: 2-Hydroxybutyrate

metaR GALU
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.7.9
product: MODEL1310110046#
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110046#
type: Reaction
name: UTP-glucose-1-phosphate uridylyltransferase
fast: false
is: SBO:0000176
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_4e9ea042_bd84_4712_9994_cc44433be289
has only substance units: false
type: Species
name: AK2
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:204

http://identifiers.org/biomodels.db/MODEL1310110046#_64afa75c_92b5_4cd8_b171_a650610ae93e
is encoded by: hsa:6522
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: F8W682
initial amount: NaN
name: SLC4A2

metaR DNDPt18m
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110046#
name: dUDP transport via ADP antiport
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
product: MODEL1310110046#

metaM 3mob m
has only substance units: false
is: HMDB00019
type: Species
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:11851

metaM pail5p hs n
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
initial amount: NaN
constant: false

metaM acmana c
initial amount: NaN
is: CHEBI:17122
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01129
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
name: N-acetyl-D-mannosamine
is: SBO:0000247

metaR UPPDC1
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.37
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
reversible: false
is described by: ECO:0000269
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)

metaR r1593
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR MALSO3tm
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
product: MODEL1310110046#
name: Malate:sulfite antiport, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
reversible: true
is: SBO:0000185

metaM pyr c
constant: false
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00022
type: Species
initial concentration: 1.0
is: CHEBI:15361
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110046#_1e5116ec_c78e_4912_bd0c_2146386fbe96
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: Q9Y2P5
name: SLC27A5
is encoded by: hsa:10998
initial concentration: NaN

metaR GALT
is described by: ECO:0000000
product: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
name: galactose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_fbc4a2a1_16ee_4213_9e7e_db00f434efc2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4725
type: Species
has only substance units: false
name: NDUFS5
initial amount: NaN
constant: false
is: SBO:0000252
is: Q6IBA0

metaR FATP2t
fast: false
modifier: MODEL1310110046#
product: MODEL1310110046#
name: fatty acid electroneutral transport
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_2ed60aa9_d4da_499f_9732_d2e7310a7d3a
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:10599
has only substance units: false
is: Q9Y6L6
name: SLCO1B1
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_9cfe0aa5_1439_4f78_aad1_5f11aa223601
initial amount: NaN
constant: false
boundary condition: true
name: GPD1
initial concentration: NaN
is: F8W1L5
is encoded by: hsa:2819
type: Species
is: SBO:0000252
has only substance units: false

metaR GLNyLATthc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_2820893c_7dbf_4596_a9a6_7ee026f8d93c
has only substance units: false
name: PMM1
is encoded by: hsa:5372
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: A8K003
constant: false

metaR O2t
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
kinetic law: MODEL1310110046#
name: o2 transport (diffusion)
reversible: true
fast: false

metaR r1594
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 3aib D m
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02299
constant: false
name: D-3-Amino-isobutanoate
is: C03265

metaM thym e
name: thymine
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
initial amount: NaN
is: CHEBI:17821
is: HMDB00262
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

metaM xol7ah2al c
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
is: CHEBI:27428
is: HMDB06894
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1ae92e8a_26f5_442f_ba98_4374c6f79e22
name: NME1
is encoded by: hsa:4830
type: Species
boundary condition: true
initial concentration: NaN
is: P15531
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_2a28a968_6a81_477c_a917_d64a58eecb03
is: SBO:0000297
name: EHHADH:ACAA1:HSD17B4:ACOX3
type: Species
boundary condition: true
initial concentration: NaN
has part: O15254
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:8310

metaR FAOXC14C12m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_9d891dee_0706_48d6_8f93_c2dae7b81b62
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10768
name: AHCYL1
initial amount: NaN

metaM s2l2n2m2m l
initial concentration: 1.0
is: HMDB00573
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: de-Fuc form of PA6 (w/o peptide linkage)
is: CHEBI:30825
constant: false
notes: FORMULA: C84H136N6O62 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110046#_870a8dc8_46f6_4393_a0f4_32e7ebe4dace
initial amount: NaN
is encoded by: hsa:7371
name: UCK2
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9BZX2
constant: false

metaR 3DSPHR
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.102
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
name: 3-Dehydrosphinganine reductase

http://identifiers.org/biomodels.db/MODEL1310110046#_2dd23bab_c127_436a_bfd5_5e1305047373
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:728441
has only substance units: false
is: SBO:0000252
name: GGT2

http://identifiers.org/biomodels.db/MODEL1310110046#_a97c2df7_a98c_4aa0_bea5_ebbf77b32f6c
type: Species
name: LDHB
is: P07195
is encoded by: hsa:3945
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaR r1595
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_51341e7c_1902_4574_b6c3_39130ad6224c
boundary condition: true
is encoded by: hsa:8883
name: NAE1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: A8MU28

metaR r2392
kinetic law: MODEL1310110046#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_e25d043c_31e6_4522_9604_55b8203dd64a
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4190
has only substance units: false
initial concentration: NaN
is: B7Z3I7
name: MDH1
type: Species
boundary condition: true
constant: false

metaR r1866
modifier: MODEL1310110046#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_a18419cd_c6f8_46aa_961a_c18feffbd169
name: HMGCS2
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3158
is: P54868
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_78c8fa2f_f757_47fa_b523_5d078abd9986
constant: false
is: O00400
initial amount: NaN
is: SBO:0000252
name: SLC33A1
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9197

metaR MMSAD1m
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
product: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_2975eab0_424d_422c_bb42_24a205a8f858
is: SBO:0000252
initial concentration: NaN
is: O14975
is encoded by: hsa:11001
initial amount: NaN
has only substance units: false
name: SLC27A2
type: Species
constant: false
boundary condition: true

metaM c14dccoa x
has only substance units: false
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
name: tetradecanedioylcoa
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB02288
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_38273d7f_44f4_49c9_959e_86523989ccf8
type: Species
name: SLC4A5
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57835
initial amount: NaN

metaR FMNAT
kinetic law: MODEL1310110046#
is: SBO:0000176
name: FMN adenylyltransferase
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reversible: false
reactant: MODEL1310110046#
is described by: ECO:0000134
product: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.2

metaM fuc L l
name: L-fucose
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247
is: HMDB00174
is: CHEBI:18287

metaM o2s e
constant: false
name: superoxide
type: Species
is: CHEBI:18421
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
has only substance units: false

metaM tetd7ecoa m
is: HMDB13109
constant: false
boundary condition: false
name: 7-tetradecenoylcoa
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_a0e31e2c_987a_4d37_a5c1_c3dc8d8e4d9f
is: Q6ZMU0
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:210
name: ALAD
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_762fe82e_0b3a_427c_b25c_74ef3ca2bc3c
is: P51160
is encoded by: hsa:5146
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PDE6C
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_65a812cc_de66_4c90_a925_b5f3df19eb66
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8790
type: Species
name: FPGT
boundary condition: true
is: O14772

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR r1596
reversible: true
product: MODEL1310110046#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_68bf3cdc_f490_4709_98a7_15d0316f50f8
name: ATP1A4:ATP1B1
initial concentration: NaN
constant: false
has only substance units: false
type: Species
has part: Q13733
is: SBO:0000297
is encoded by: hsa:480
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_692cbefc_009d_41fa_a022_c753f2b5e140
initial concentration: NaN
type: Species
has only substance units: false
name: GPX4
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2879
is: P36969

metaR r0390
reversible: true
kinetic law: MODEL1310110046#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
type: Reaction
reactant: MODEL1310110046#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110046#
is described by: ECO:0000000

metaR LNLNCGt
kinetic law: MODEL1310110046#
fast: false
type: Reaction
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_2bc90c24_b642_4d8c_8a24_db30ddef1d7f
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:137872
initial amount: NaN
name: ADHFE1
type: Species
is: Q8IWW8

metaR FAS140COA
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
name: fatty-acyl-CoA synthase (n-C14:0CoA)
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_8e506626_3cef_46f9_8ba3_57d272efbe3e
is: O75356
is: SBO:0000252
boundary condition: true
is encoded by: hsa:957
constant: false
initial amount: NaN
type: Species
name: ENTPD5
has only substance units: false
initial concentration: NaN

metaM hexe3coa m
constant: false
name: 3-hexenoylcoa
initial amount: NaN
is: HMDB06522
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

metaR r1597
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110046#_5a1ba26d_b77b_4368_a347_c0007b0dab50
is: P47989
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: XDH
initial amount: NaN
is encoded by: hsa:7498
boundary condition: true

metaR r0391
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
reversible: true
type: Reaction
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_6c54399c_e99f_4d76_a4af_1efe31534331
name: _AI191472_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AI191472
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_496edb78_b8a3_4259_baa2_9982877c7975
is encoded by: hsa:26503
initial amount: NaN
name: SLC17A5
is: SBO:0000252
boundary condition: true
is: Q9NRA2
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaR UMPK2
modifier: MODEL1310110046#
product: MODEL1310110046#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (CTP)
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM andrstrn r
constant: false
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16032
name: androsterone
is: SBO:0000247
is: HMDB00031

metaM orot5p c
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57538
is: C01103
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
has only substance units: false
constant: false
is: HMDB00218
initial concentration: 1.0
name: Orotidine 5'-phosphate

metaM 25aics c
is: HMDB00797
has only substance units: false
is: SBO:0000247
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
initial amount: NaN
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
type: Species
is: C04823
is: CHEBI:58443
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_f6e1c71d_0463_4363_b4af_6b065bfda914
is: SBO:0000252
is encoded by: hsa:251
name: ALPPL2
initial amount: NaN
boundary condition: true
type: Species
is: P10696
has only substance units: false
constant: false
initial concentration: NaN

metaM 5adtststerones e
type: Species
is: HMDB06278
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial concentration: 1.0
has only substance units: false
constant: false
name: 5alpha-Dihydrotestosterone sulfate

metaR ARABR
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110046#
name: arabinose reductase
reversible: false

metaR PNTEH
name: Hydrolase Class ( RXN R02973)
is described by: ECO:0000269
fast: false
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.5.1.92
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
modifier: MODEL1310110046#

metaM strch2 e
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:4167
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H32O16 CHARGE: 0
is: HMDB00122

metaR r0287
reversible: false
reactant: MODEL1310110046#
fast: false
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_3b6d02f9_6626_49f1_a6d0_dbd9f4169b93
name: ACOX1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q15067

metaR VACCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110046#
fast: false
reversible: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
name: transport into the mitochondria (carnitine)
type: Reaction
is described by: ECO:0000269

metaR S6T5g
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110046#
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_f4e7740a_f597_472f_bf55_b6efd201cc30
is: SBO:0000252
has only substance units: false
type: Species
name: ACO2
is: Q99798
initial concentration: NaN
boundary condition: true
is encoded by: hsa:50
initial amount: NaN
constant: false

metaR r0392
reversible: true
type: Reaction
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110046#

metaR r1598
kinetic law: MODEL1310110046#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_02378fb5_2813_45df_a80a_cdbbbd58426c
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:113451
initial amount: NaN
name: ADC
boundary condition: true
is: Q96A70
type: Species
initial concentration: NaN

metaR UMPK3
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110046#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP)

http://identifiers.org/biomodels.db/MODEL1310110046#_d5ce2136_2d4c_4de0_86d2_da3582ef32c8
boundary condition: true
initial concentration: NaN
name: DPM2
has only substance units: false
is encoded by: hsa:8818
is: SBO:0000252
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_1380d791_e555_4d91_b27a_aebd43dac7ad
name: INPP5J
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q15735
initial concentration: NaN
type: Species
is encoded by: hsa:27124
initial amount: NaN

metaM docosahexcoa m
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3,7,10,13,16,19-docosahexenoylcoa
constant: false
boundary condition: false

metaM C05957 r
is: CHEBI:27485
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: HMDB02710
name: Prostaglandin J2
type: Species
boundary condition: false
has only substance units: false

metaR r0393
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000000
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_7a6dda11_2c2f_4444_b1d0_f99b46aad83e
initial concentration: NaN
has only substance units: false
is: P30837
initial amount: NaN
is encoded by: hsa:219
type: Species
name: ALDH1B1
boundary condition: true
constant: false
is: SBO:0000252

metaM cgly c
is: HMDB00078
has only substance units: false
name: L-cysteinylglycine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial amount: NaN
is: CHEBI:4047
constant: false

metaR r1599
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000

metaR GASNASE3ly
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
name: glycosylasparaginase, lysosomal
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
is: SBO:0000176
product: MODEL1310110046#
reversible: false
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaM ksii core4 pre5 g
type: Species
is: HMDB00175
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00130
name: keratan sulfate II biosynthesis, precursor 5
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: CHEBI:58053

metaR PSP L
fast: false
name: phosphoserine phosphatase (L-serine)
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.3
reactant: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_caea90c5_3f9b_4c20_b569_bf8cdc0d4b28
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q99519
name: NEU1
boundary condition: true
type: Species
is encoded by: hsa:4758

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_37af2b57_14d9_42e7_9ee7_2400bfdf53e9
type: Species
is: P34059
is encoded by: hsa:2588
is: SBO:0000252
name: GALNS
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaR VACCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
fast: false
name: fatty acid transport via diffusion
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#

metaR r1155
reactant: MODEL1310110046#
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: false
product: MODEL1310110046#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:

metaM HC02217 e
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2

metaR r1589
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
is: SBO:0000185
type: Reaction
fast: false

metaR r2126
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_e288d1e1_5573_455b_9490_8deb2567bb93
initial amount: NaN
initial concentration: NaN
constant: false
is: Q99624
is encoded by: hsa:10991
is: SBO:0000252
type: Species
has only substance units: false
name: SLC38A3
boundary condition: true

metaM glysar e
name: Glycylsarcosine
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/93131
notes: FORMULA: C5H10N2O3 CHARGE: 0
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM glysar c
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/93131
initial amount: NaN
constant: false
initial concentration: 1.0
name: Glycylsarcosine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_3b04e992_1461_496d_8345_8e6f313a61d0
initial amount: NaN
is encoded by: hsa:30833
constant: false
name: NT5C
is: SBO:0000252
is: Q8TCD5
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r1588
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
reversible: true
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaM tetdecdicoa m
type: Species
initial concentration: 1.0
name: 5,8-tetradecadienoylcoa
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
is: HMDB02288
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_0e26cfc5_5c87_46bf_abcc_ffae1021b6fe
initial concentration: NaN
is encoded by: hsa:2109
initial amount: NaN
name: ETFB
is: SBO:0000252
is: P38117
has only substance units: false
constant: false
boundary condition: true
type: Species

metaR CSNAT3x
name: carnitine O-aceyltransferase, peroxisomal
modifier: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176

metaM dcsptn1coa c
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173
is: HMDB06513
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
constant: false

metaM undcoa m
is: HMDB13114
initial concentration: 1.0
name: undecanoylcoa
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_3af32901_20e5_4ab9_8d70_9c8a73bc7c0c
initial amount: NaN
name: NDUFB6
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:4712
has only substance units: false
constant: false
is: Q5VYT2
is: SBO:0000252

metaR TCYNTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
fast: false
reversible: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Thiocyanate transport via diffusion (mitochondrial)

metaR r1154
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
name: EC:1.2.7.2
reversible: true

metaM cpppg3 c
is: HMDB01261
is: CHEBI:57309
name: Coproporphyrinogen III
is: C03263
initial amount: NaN
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_0296fa9f_7777_4b5d_944a_671735d83f23
name: MTMR3
is encoded by: hsa:8897
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaR r2127
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_f0626389_0064_4c17_8dc4_5924561b444b
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:4967
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has part: B4E3E9
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110046#_3b2b120a_cfcf_495b_aa6d_f93854926882
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:W74642
name: _W74642_1_c

http://identifiers.org/biomodels.db/MODEL1310110046#_32c46018_7da2_4570_bc36_ec57d89441e2
name: PANK1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:53354
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaM man1p c
boundary condition: false
is: SBO:0000247
is: HMDB06330
has only substance units: false
is: CHEBI:35374
initial concentration: 1.0
type: Species
name: D-Mannose 1-phosphate
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_81ea73d9_47f5_4c49_a09d_57b280e4bd61
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: TXNRD3
boundary condition: true
is: Q86VQ6
constant: false
is encoded by: hsa:114112
has only substance units: false

metaR CYSGLUexR
name: L-cysteine/L-glutamine reversible exchanger
modifier: MODEL1310110046#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_70e2d32c_f99f_4657_a594_3c0e098b838d
has part: P27986
constant: false
is encoded by: hsa:5295
name: PIK3CA:PIK3R1
type: Species
is: SBO:0000297
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_6d74e7ad_9af3_45e9_b95e_bddd9c118e41
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: CPT2
constant: false
is: P23786
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1376

http://identifiers.org/biomodels.db/MODEL1310110046#_7db4204a_8e66_45dd_81ce_af90dcd66c47
is: Q99714
boundary condition: true
is encoded by: hsa:3028
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: HSD17B10

http://identifiers.org/biomodels.db/MODEL1310110046#_a8d51185_0ef0_4127_bfb8_bb790fd31393
boundary condition: true
is encoded by: hsa:5152
name: PDE9A
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_e37e7fce_e949_46a6_b5ad_9c8cd55f5628
name: PDE10A
initial amount: NaN
is: Q9Y233
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10846
is: SBO:0000252

metaM sgalside hs c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16523
has only substance units: false
is: HMDB03406
type: Species
name: sulfatide galactocerebroside
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
initial amount: NaN
constant: false

metaR r1649
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

metaR r2124
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
product: MODEL1310110046#

metaM aps c
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58243
name: 5'-adenylyl sulfate(2-)
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01003

metaR S6T8g
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
fast: false

metaM h2o g
type: Species
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial amount: NaN
name: water
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110046#_c18643ee_de58_4650_97e8_a27de57f8c9c
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P13995
initial concentration: NaN
initial amount: NaN
name: MTHFD2
is encoded by: hsa:10797
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_fd7cbfce_6144_4e69_8eca_a0e5004e50f8
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: ST3GAL5
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8869
is: Q9UNP4
has only substance units: false

metaR GALK
product: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.6
is version of: http://identifiers.org/ec-code/2.7.1.157
name: galactokinase
fast: false
reversible: false

metaM thcholstoic r
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
is: HMDB03873
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM 3hexdtricoa m
boundary condition: false
is: HMDB02288
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9c37e9d5_e523_4b53_a0eb_4f0d50d806d0
is: Q9UGH3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9962
initial amount: NaN
name: SLC23A2
constant: false
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_1246a682_d542_40e9_85b7_5b88c6d576e1
type: Species
is: SBO:0000252
is encoded by: hsa:BC005314
name: _BC005314_1_x
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaR r2125
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_404bd772_8a38_4a2f_8472_581e32ded8c0
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:AF116616
initial concentration: NaN
name: _AF116616_1_m
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9d95af5d_822a_4973_80dd_af4fe8891850
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: O76083
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A

metaM glygn5 e
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C12H21O11X CHARGE: 0
is: C00116
is: HMDB00131
constant: false
is: CHEBI:17754
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

metaM L2aadp6sa c
is: CHEBI:17917
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01263
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
constant: false
name: L-allysine

metaM msa m
is: HMDB11111
initial concentration: 1.0
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: SBO:0000247
has only substance units: false
name: 3-oxopropanoate
initial amount: NaN
boundary condition: false
is: CHEBI:33190
type: Species

metaR r1647
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110046#
type: Reaction
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_f141aa42_660c_47e6_ae06_f98c4ece1e31
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: O95498
initial concentration: NaN
constant: false
is encoded by: hsa:8875
name: VNN2
has only substance units: false

metaM h2o e
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
name: H2O
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB02111
is: C00001

metaR PRO Dtde
reversible: true
name: D-proline transport, extracellular
fast: false
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is: SBO:0000185
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR BDHm
is described by: ECO:0000269
reactant: MODEL1310110046#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.30
modifier: MODEL1310110046#
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT

metaR RE3524R
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110046#
fast: false
reversible: true
name: RE3524
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_07c66c50_14f2_426b_bd83_22745e56cb54
has only substance units: false
name: COQ6
initial concentration: NaN
is encoded by: hsa:51004
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: B7Z3K8

metaR r2395
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#

metaM sph1p e
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383
initial concentration: 1.0
type: Species
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57939

http://identifiers.org/biomodels.db/MODEL1310110046#_8fb4ba2f_65fe_448a_8680_48c75e718ca6
type: Species
is: E9PCP2
boundary condition: true
name: CPT1B
is encoded by: hsa:1375
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_e251683b_a928_41db_b0a4_2ea5ce18cf33
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: HAS1
is: Q8IYH3
constant: false
initial concentration: NaN
is encoded by: hsa:3036
boundary condition: true

metaR CMPSASn
kinetic law: MODEL1310110046#
fast: false
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110046#
name: CMP sialic acid synthase, nuclear
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reversible: false
is: SBO:0000176
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.7.43
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_578b9513_e861_4572_b1c6_b2bf9a54f59d
type: Species
initial concentration: NaN
has only substance units: false
is: P07741
name: APRT
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:353
is: SBO:0000252

metaR r1150
is: SBO:0000185
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
modifier: MODEL1310110046#
is described by: ECO:0000000
name: Facilitated diffusion
product: MODEL1310110046#
type: Reaction

metaR THRCYSNaEx
is: SBO:0000185
fast: false
is described by: ECO:0000269
modifier: MODEL1310110046#
reversible: false
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#

metaM retfa c
name: fatty acid retinol
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00305
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
has only substance units: false
boundary condition: false
is: CHEBI:50211
type: Species

metaR ADMDC
reversible: false
product: MODEL1310110046#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.50
name: adenosylmethionine decarboxylase
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110046#_4ea9cb32_6020_446d_a7c6_3617c62729f7
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:192134
name: B3GNT6
constant: false
is: A8K9Q8
boundary condition: true

metaM pglyc hs e
has only substance units: false
boundary condition: false
constant: false
name: phosphatidylglycerol(1-)
initial amount: NaN
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
is: SBO:0000247
is: CHEBI:60523
initial concentration: 1.0

metaM 5aop c
initial amount: NaN
initial concentration: 1.0
is: C00430
is: HMDB01149
has only substance units: false
name: 5-Amino-4-oxopentanoate
boundary condition: false
constant: false
type: Species
is: CHEBI:17549
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430

metaR r1648
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000

metaM decdp c
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB06288
boundary condition: false
name: all trans Decaprenyl diphosphate

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaM leuktrE4 e
is: HMDB02200
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
name: leukotriene E4(1-)
constant: false
is: CHEBI:57462
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR L LACt4r
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110046#
name: L-lactate reversible transport via sodium symport
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_48aa0234_3201_4953_aec1_f52a7eff31bf
is: SBO:0000252
constant: false
name: _AI697028_1_e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI697028
boundary condition: true
type: Species
initial amount: NaN

metaR HYXNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
product: MODEL1310110046#
reversible: true
fast: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
name: Hypoxanthine transport

http://identifiers.org/biomodels.db/MODEL1310110046#_00c3db03_667b_4830_9d74_f0ae3ae0af4f
type: Species
is: Q6FHI7
initial amount: NaN
has only substance units: false
is encoded by: hsa:762
boundary condition: true
name: CA4
is: SBO:0000252
initial concentration: NaN
constant: false

metaM HC02217 c
is: SBO:0000247
name: prostaglandin-g2
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:27647
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_522f0462_aa4a_47f7_9d1f_020a3eea2eb3
is encoded by: hsa:518
has only substance units: false
constant: false
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is: SBO:0000297
type: Species
initial concentration: NaN

metaM thcholstoic m
type: Species
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
is: SBO:0000247
is: HMDB03873
has only substance units: false

metaM cs e l
is: CHEBI:36005
initial amount: NaN
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB02183
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
has only substance units: false

metaR PCREATtmdiffir
reversible: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: Phosphocreatine transport to/from mitochondria via diffusion
type: Reaction
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:14977199,PMID:3896131 NOTES:SAB
product: MODEL1310110046#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_95ef0919_3c5e_4a96_b5fa_2f26d5fb45e1
has only substance units: false
initial amount: NaN
is encoded by: hsa:23057
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: NMNAT2

metaM sgalside hs g
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00061
is: CHEBI:58343
constant: false
has only substance units: false

metaR r2128
is: SBO:0000185
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_5b34e11e_d871_4303_9a66_962ad96dfcae
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:27115
initial concentration: NaN
name: PDE7B
has only substance units: false
is: Q9NP56

metaM h2o c
is: C00001
boundary condition: false
name: H2O
constant: false
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:3303
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110046#_3dac2742_4de2_48b2_923f_69fe2dfb11ed
is encoded by: hsa:5151
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: PDE8A
initial amount: NaN
boundary condition: true

metaM strch1 e
is: CHEBI:456215
boundary condition: false
is: C00020
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00045
notes: FORMULA: C66H112O56 CHARGE: 0
type: Species
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})
has only substance units: false

metaR r1798
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: false
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
name: Y+LAT2 Utilized transport
type: Reaction

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR r1645
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110046#
reversible: true
type: Reaction
kinetic law: MODEL1310110046#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110046#
is: SBO:0000185

metaM strdnccoa m
has only substance units: false
is: HMDB06519
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: stearidonyl coenzyme A
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
is: C16163
is: http://identifiers.org/pubchem.compound/47205473

metaM c10dc x
name: sebacoyl carnitine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB04047
boundary condition: false
is: C14143
notes: FORMULA: C17H30NO6 CHARGE: -1
constant: false

metaR r2397
kinetic law: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110046#

metaR HMGCOASi
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
name: Hydroxymethylglutaryl CoA synthase (ir)
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
modifier: MODEL1310110046#

metaM xan c
initial concentration: 1.0
is: CHEBI:17712
is: SBO:0000247
boundary condition: false
name: Xanthine
is: HMDB00292
has only substance units: false
constant: false
is: C00385
initial amount: NaN
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
type: Species

metaM mev R c
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00227
name: (R)-mevalonate

http://identifiers.org/biomodels.db/MODEL1310110046#_02240deb_2e09_4cc0_b864_fbc8b9960d38
boundary condition: true
is: SBO:0000252
name: RRM2B
type: Species
has only substance units: false
initial amount: NaN
is: Q7LG56
constant: false
initial concentration: NaN
is encoded by: hsa:50484

metaR r2129
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1799
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: false
product: MODEL1310110046#
fast: false

metaR r1646
is described by: ECO:0000000
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_a58f66a2_323f_47d5_90b6_213fd51cdcc3
constant: false
boundary condition: true
is encoded by: hsa:3295
has only substance units: false
initial concentration: NaN
has part: E9PB82
type: Species
name: ACAA1:HSD17B4:ACOX1
initial amount: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110046#_2b44e7e7_9a0b_4a05_a30e_9bc8748adbff
name: PGM1
is: B4DPV0
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:5236
is: SBO:0000252

metaM leuktrE4 c
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
name: leukotriene E4(1-)
type: Species
is: SBO:0000247
is: HMDB02200
boundary condition: false
is: CHEBI:57462
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_5ccfc7b6_90b7_4d2d_8ae9_8f2acade1410
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:84532
initial concentration: NaN
is: Q9NUB1
name: ACSS1
is: SBO:0000252

metaM o2s x
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
is: CHEBI:18421
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: HMDB02168
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_90fb0125_d5a1_4c30_8e86_cdad28233259
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AI926493
boundary condition: true
name: _AI926493_1_m
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_61777143_a568_475a_8e33_c40b93b42cf8
has part: P15531
constant: false
is encoded by: hsa:4830
has part: P22392
type: Species
is encoded by: hsa:4831
has only substance units: false
initial concentration: NaN
is: SBO:0000297
name: NME1:NME2
initial amount: NaN
boundary condition: true

metaR DAGt
product: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110046#
name: diacylglycerol transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_d995d075_fa91_4f1e_800d_c515ffb1247a
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:100287639
boundary condition: true
name: _100287639_1_c
constant: false

metaM 12ppd S c
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: SBO:0000247
has only substance units: false
is: HMDB06213
initial concentration: 1.0
initial amount: NaN
name: (S)-propane-1,2-diol
type: Species
constant: false
is: CHEBI:29002

metaR ADSL1
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110046#
is: SBO:0000176
fast: false
type: Reaction
name: adenylosuccinate lyase
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
reactant: MODEL1310110046#
reversible: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269

metaR r1643
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000

metaR GALASE14ly
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_db52aa2e_0ddb_4a64_aada_8db5adf3d220
boundary condition: true
constant: false
initial amount: NaN
has part: B4DER4
has part: B3KT19
is: SBO:0000297
is encoded by: hsa:5295
has only substance units: false
name: PIK3CB:PIK3R1
initial concentration: NaN
is encoded by: hsa:5291
type: Species

metaR r2534
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
reversible: true

metaM h2o r
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB02111
boundary condition: false
is: C00001
is: CHEBI:15377
is: SBO:0000247
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false

metaM phyt e
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: phytanate
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: HMDB00801
boundary condition: false
is: CHEBI:37257
initial amount: NaN

metaR GLNASNNaEx
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110046#

metaM Rtotal3coa c
initial amount: NaN
name: R total 3 Coenzyme A
has only substance units: false
boundary condition: false
is: HMDB01448
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: CHEBI:16189
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f6324e14_6b58_42f5_8034_b49293ab4245
boundary condition: true
is: Q01433
type: Species
is encoded by: hsa:271
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: AMPD2
constant: false
has only substance units: false

metaR r2535
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#

metaR r1644
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
fast: false
reactant: MODEL1310110046#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM 3mox4hoxm c
is: SBO:0000247
is: CHEBI:27622
initial concentration: 1.0
type: Species
name: 3-Methoxy-4-hydroxymandelate
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00291
has only substance units: false

metaR OIVD2m
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.168
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: false
is version of: http://identifiers.org/ec-code/1.2.4.4
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#

metaR RETNt
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
name: retinoic acid transport

http://identifiers.org/biomodels.db/MODEL1310110046#_4191a5f3_2864_4f1b_92f2_bc27d9f2022a
name: SUCLG1
is: P53597
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8802

metaR ADSL2
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: adenylosuccinate lyase
fast: false
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
product: MODEL1310110046#

metaR C4x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaM dcyt c
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: Deoxycytidine
is: SBO:0000247
is: C00881
is: HMDB00014
boundary condition: false
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
has only substance units: false

metaR M4MPDOL Lter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
name: m4mpdol flippase

metaR RE1530C
reactant: MODEL1310110046#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reversible: true

metaR RETH1e
reversible: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110046#
name: retinyl ester hydrolase (9-cis), extracellular
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
fast: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_0c94d49e_8998_4c45_99b4_9d0e2fc935f9
name: ALG2
boundary condition: true
is: Q9H553
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:85365
type: Species
constant: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR XOL7AONEtr
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
reversible: true
product: MODEL1310110046#
name: lipid, flip-flop intracellular transport

metaR r1641
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
is: SBO:0000185
type: Reaction

metaM fad e
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
is: CHEBI:16238
initial amount: NaN
is: C00016
has only substance units: false
is: HMDB01248
boundary condition: false
name: Flavin adenine dinucleotide oxidized

metaM tetdecdicoa x
is: HMDB02288
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: 5,8-tetradecadienoylcoa
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR S6TASE16ly
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176

metaR r2532
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaM nh4 n
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
name: ammonium
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28938

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR METtec
is: SBO:0000185
name: L-methionine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110046#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110046#
reactant: MODEL1310110046#

metaM dcsptn1coa m
initial amount: NaN
is: C16173
has only substance units: false
constant: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_584332f5_c3a6_4dc9_aa75_56528fb9d0c0
initial amount: NaN
is: Q96RV2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3038
name: HAS3
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR PNTK
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: pantothenate kinase
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.33
reactant: MODEL1310110046#
fast: false
product: MODEL1310110046#

metaM dolp U c
constant: false
boundary condition: false
is: CHEBI:57683
has only substance units: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
initial amount: NaN
initial concentration: 1.0
name: dolichyl phosphate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_b499e40d_e392_4443_b899_e1527fb0dea2
is encoded by: hsa:3098
is: Q59FD4
type: Species
has only substance units: false
name: HK1
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM pglyc hs c
constant: false
is: SBO:0000247
notes: FORMULA: CHARGE: 0
is: CHEBI:21338
initial amount: NaN
boundary condition: false
name: pglyc_hs[c]
type: Species
initial concentration: 1.0
is: HMDB02704
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_00ddcc3a_d8af_4464_b741_891e8a47dc8e
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q96KJ9
is: SBO:0000252
is encoded by: hsa:84701
initial amount: NaN
constant: false
name: COX4I2

metaR r1642
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
fast: false

metaR FAOXC226C205m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM sph1p c
constant: false
is: CHEBI:57939
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
is: SBO:0000247
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
is: HMDB01383
has only substance units: false

metaR r2122
product: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_737d2d0e_4343_4670_bb25_7914565f5b0d
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:116285
has only substance units: false
is: Q08AH1
initial amount: NaN
name: ACSM1
initial concentration: NaN
type: Species

metaM strdnccoa c
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
is: C16163
has only substance units: false
name: stearidonyl coenzyme A
is: HMDB06519
type: Species
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205473
initial amount: NaN

metaM nh4 m
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
is: HMDB00051
initial concentration: 1.0
name: Ammonium
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: C01342

metaR r2538
kinetic law: MODEL1310110046#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

metaM h2o n
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: HMDB02111
is: CHEBI:15377
initial amount: NaN
is: SBO:0000247
name: water
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaR S6TASE13ly
kinetic law: MODEL1310110046#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaM fad c
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
is: HMDB01248
name: Flavin adenine dinucleotide oxidized
initial amount: NaN

metaR FACOAL245 2
is described by: ECO:0000269
reactant: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: fatty-acid--CoA ligase
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110046#
reversible: true

metaR r2123
type: Reaction
fast: false
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_750a17b8_6a29_43ea_8537_2ac0e31596e2
boundary condition: true
type: Species
is encoded by: hsa:2954
is: SBO:0000252
initial concentration: NaN
name: GSTZ1
has only substance units: false
is: A6NED0
initial amount: NaN
constant: false

metaR RE0935E
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110046#
fast: false
name: RE0935

metaM ha pre1 e
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
is: CHEBI:16126
boundary condition: false
type: Species
name: hyaluronan biosynthesis, precursor 1
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR r2539
reversible: true
fast: false
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR BMTer U
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
modifier: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
fast: false
is: SBO:0000176
name: B mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_79d0030f_4872_4f88_92c7_93b8d0c58bbb
type: Species
initial amount: NaN
is encoded by: hsa:1841
name: DTYMK
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is: P23919

metaM sbt D c
name: D-glucitol
type: Species
initial amount: NaN
is: CHEBI:17924
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false

metaM thcholstoic x
constant: false
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
is: CHEBI:18402

http://identifiers.org/biomodels.db/MODEL1310110046#_56d0e5f2_741c_4cfc_be79_e49a94f0f4c4
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: O75912
is encoded by: hsa:9162
constant: false
initial amount: NaN
name: DGKI
has only substance units: false

metaM agm m
constant: false
is: CHEBI:58145
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01432
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H16N4 CHARGE: 2 INCHI: InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9)/p+2 HEPATONET_1.0_ABBREVIATION: HC00171 EHMN_ABBREVIATION: C00179
name: agmatinium(2+)
initial concentration: 1.0

metaM h2o m
initial concentration: 1.0
name: H2O
constant: false
is: CHEBI:15377
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
type: Species
is: C00001
has only substance units: false
is: SBO:0000247
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110046#_61099398_9d07_4074_9ce4_3519deae904a
constant: false
is encoded by: hsa:226
name: ALDOA
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P04075
type: Species
initial amount: NaN

metaR r1640
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_20f84eef_557c_4a43_b704_5b8007d137ee
name: ATP5H
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: A0PJH2
constant: false
is encoded by: hsa:10476
boundary condition: true
initial amount: NaN
type: Species

metaM HC01415 m
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:27537
constant: false
initial concentration: 1.0
name: (2E)-Octenoyl-CoA
boundary condition: false
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276

metaR r2120
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_f33bfddc_3f0a_4653_90d1_c1bbd5fbefa6
is: Q9UJ70
initial concentration: NaN
constant: false
name: NAGK
is encoded by: hsa:55577
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_222884b3_ddb9_4100_9e2c_e5968733e72e
name: AKR7A2
is: O43488
type: Species
is encoded by: hsa:8574
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

metaR UREAt
kinetic law: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
fast: false
name: Urea transport via facilitate diffusion
reactant: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
type: Reaction
modifier: MODEL1310110046#
reversible: true

metaM hgentis c
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: HMDB00130
is: CHEBI:16169
type: Species
initial amount: NaN
name: homogentisate

http://identifiers.org/biomodels.db/MODEL1310110046#_0e11fe78_45f7_4890_bdcb_64f6a677ab6f
type: Species
constant: false
is: O00400
has only substance units: false
boundary condition: true
is encoded by: hsa:9197
initial amount: NaN
name: SLC33A1
initial concentration: NaN
is: SBO:0000252

metaM phyt c
name: phytanate
initial amount: NaN
is: CHEBI:37257
is: SBO:0000247
constant: false
has only substance units: false
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
boundary condition: false
initial concentration: 1.0
is: HMDB00801

metaM HC01459 x
initial amount: NaN
constant: false
is: CHEBI:27458
type: Species
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450

metaM h2o l
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
type: Species
is: HMDB02111
initial concentration: 1.0
is: CHEBI:15377

metaR r0081
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12

metaM pyr m
is: SBO:0000247
is: HMDB00243
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
name: pyruvate
type: Species
initial concentration: 1.0
is: CHEBI:15361
is: C00022
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_bcf7d55f_46db_4241_b8ae_cebcc4976e39
is encoded by: hsa:113
initial amount: NaN
constant: false
is: SBO:0000252
is: P51828
type: Species
has only substance units: false
name: ADCY7
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_20963813_0de3_431e_bb67_bdc9ad334a27
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:518
constant: false
name: ATP5G3
type: Species
has only substance units: false

metaM 5aop m
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17549
is: C00430
name: 5-Amino-4-oxopentanoate
initial concentration: 1.0
is: HMDB01149
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_8f33f5f4_3f8d_45c2_9411_facdd4ccb849
initial concentration: NaN
name: SLC12A4
type: Species
constant: false
is encoded by: hsa:6560
is: F5H066
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_5a0dca85_9cec_4a28_818f_e870353aee85
has only substance units: false
constant: false
boundary condition: true
type: Species
has part: Q9P2X0
initial amount: NaN
name: DPM3:DPM1:DPM2
is: SBO:0000297
is encoded by: hsa:54344
initial concentration: NaN
is encoded by: hsa:8818

metaR r2121
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR r2537
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
reversible: true
name: Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000185

metaR DM fol
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR SPMS
product: MODEL1310110046#
name: spermidine synthase
modifier: MODEL1310110046#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.16
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_50c5f63d_4a91_49ce_ad92_57d8b3be8fd3
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ATP5J
is: Q6NZ59
initial concentration: NaN
type: Species
is encoded by: hsa:522

metaM sbt D e
is: HMDB00247
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
type: Species
initial concentration: 1.0
has only substance units: false
name: D-glucitol
is: SBO:0000247
constant: false

metaM dcyt e
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: C00881
is: SBO:0000247
is: HMDB00014
is: CHEBI:15698
initial amount: NaN
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaR r1156
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
is: SBO:0000176
reactant: MODEL1310110046#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110046#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_fa58517b_0d19_49fe_ae3c_a749e106f8e2
is: SBO:0000252
has only substance units: false
is: Q92185
initial amount: NaN
boundary condition: true
is encoded by: hsa:6489
initial concentration: NaN
constant: false
name: ST8SIA1
type: Species

metaR FACOAL245 1
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110046#
name: fatty-acid--CoA ligase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110046#
reactant: MODEL1310110046#

metaR SMPD3g
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.4.12
reversible: false
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
fast: false
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_c854a7fa_a6d5_43a4_bea2_3cd3a85b71cc
initial amount: NaN
name: DPM3
boundary condition: true
constant: false
is: Q9P2X0
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54344
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_6be1aa9b_dc48_4ab3_9db1_7d7a3f723c51
is encoded by: hsa:1757
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SARDH
is: A8K596
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b76874c2_afe6_4d67_bfde_5daeaa1117d1
is: P50336
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5498
initial concentration: NaN
name: PPOX
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7022d200_2686_42eb_8146_4fa9e97ee97d
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:286016
has only substance units: false
name: TPI1P2
is: SBO:0000252

metaM pro L e
is: CHEBI:17203
is: SBO:0000247
initial amount: NaN
is: HMDB00162
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
constant: false
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_cd66bbe0_b4be_4eaa_96a8_b6e85e1eb99b
is encoded by: hsa:56922
constant: false
is: Q96RQ3
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: MCCC1
is: SBO:0000252
type: Species
boundary condition: true

metaM so4 l
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
constant: false
is: HMDB01448
has only substance units: false
boundary condition: false
is: CHEBI:16189
name: sulfate
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_ff046dc8_a698_4687_a4be_867372d18a5d
initial amount: NaN
boundary condition: true
name: PDE5A
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:8654
is: G5E9C5
has only substance units: false
type: Species

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaM dhea c
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: HMDB00077
name: 3beta-hydroxyandrost-5-en-17-one
initial concentration: 1.0
is: CHEBI:28689
initial amount: NaN
boundary condition: false
constant: false

metaR ADPtx
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: ADP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_e0d9aadb_ef53_43a5_9953_ec2aabbc67dc
constant: false
has only substance units: false
is: Q9H0P0
initial concentration: NaN
name: NT5C3
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51251

metaM dha e
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
name: glycerone
has only substance units: false
initial concentration: 1.0
is: CHEBI:16016
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: HMDB01882

http://identifiers.org/biomodels.db/MODEL1310110046#_5d7bcd8a_5dec_483d_953a_05868656e3b8
has only substance units: false
boundary condition: true
is encoded by: hsa:4538
is: P03905
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ND4

http://identifiers.org/biomodels.db/MODEL1310110046#_b9d9ff3f_4f0d_4079_9bb8_cb0a9dbd9288
has only substance units: false
is encoded by: hsa:4722
name: NDUFS3
is: O75489
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_66939db7_25c6_4b35_bdde_0f6a939145d6
is encoded by: hsa:55967
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: F8VQS7
initial concentration: NaN
name: NDUFA12
type: Species
initial amount: NaN

metaR GLYt2r
reactant: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
type: Reaction
name: glycine reversible transport via proton symport
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_38f3cafe_f721_4c22_8a41_f2064819f90a
initial concentration: NaN
constant: false
is: P04035
name: HMGCR
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:3156

metaM CE5120 m
type: Species
name: trans-2-cis-8-tetradecadienoyl-CoA
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM 7dhf e
has only substance units: false
initial amount: NaN
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species
is: HMDB06559
constant: false
name: heptaglutamyl folate (DHF)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM acnam n
constant: false
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
name: N-acetylneuraminate
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:35418
initial concentration: 1.0
boundary condition: false

metaM lpchol hs c
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: lysophosphatidylcholine
is: CHEBI:60479
constant: false
initial concentration: 1.0

metaM dheas e
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:57905
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: HMDB01032
type: Species

metaR C181CPT2
fast: false
reversible: false
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: transport of Octadecenoyl-CoA into mitochondrial matrix
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
modifier: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_65928231_aeb5_4a97_ad51_e46488ea3b3d
is: P33261
constant: false
is encoded by: hsa:1557
initial amount: NaN
name: CYP2C19
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaR FAOXC163C164Gm
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_2c3ce028_44df_4c72_9c65_38b84f6c31b3
is: Q6IRT1
initial amount: NaN
name: ADH5
has only substance units: false
is encoded by: hsa:128
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_bee9c543_2d5e_41dd_9320_863a9e75013f
is encoded by: hsa:278
name: AMY1C
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P04745
is: SBO:0000252
constant: false
has only substance units: false

metaR TETPENT6COAtx
name: fatty acid intracellular transport
reversible: true
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
product: MODEL1310110046#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_98cfd5d6_5d8f_4543_90b6_892acec01690
is: Q6P1M0
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:10999
is: SBO:0000252
initial amount: NaN
constant: false
name: SLC27A4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_c4bef733_aa53_449f_8aba_4bfd9a349bcc
is encoded by: hsa:4122
is: Q9P1E4
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
name: MAN2A2
initial concentration: NaN
is: SBO:0000252

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_29812bbe_6d0b_4677_96a0_5c7063a8dc66
initial concentration: NaN
is: SBO:0000252
name: ENTPD6
type: Species
is encoded by: hsa:955
has only substance units: false
boundary condition: true
constant: false
is: O75354
initial amount: NaN

metaR PROSTGD2t
name: prostaglandin transport via bicarbonate countertransport
is described by: ECO:0000269
product: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR S6T2g
reversible: false
fast: false
product: MODEL1310110046#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110046#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110046#

metaR C181CPT1
reversible: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
name: transport of Octadecenoyl-CoA into mitochondrial matrix
is described by: ECO:0000269
fast: false

metaR ADPCOAPTE
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR O2tp
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110046#
name: O2 transport, peroxisomal
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000

metaR SR5ARr
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.5
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is: SBO:0000176
type: Reaction
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_11c26fc7_88b8_4222_9f61_9ea42135d1a5
is: P16066
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4881
initial amount: NaN
boundary condition: true
name: NPR1

http://identifiers.org/biomodels.db/MODEL1310110046#_e4274e9c_b8e9_4bd0_a235_a6678aa4546b
name: UGT1A8
is encoded by: hsa:54576
initial concentration: NaN
is: Q5DSZ6
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_0f49b0ca_7a5d_4982_9fd8_1bf75c79ad94
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:U37519
name: _U37519_1_e
constant: false
has only substance units: false
initial amount: NaN

metaM dgmp e
constant: false
is: CHEBI:57673
name: dGMP(2-)
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01044
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b9675d70_eae1_4e51_a8f9_4570cad2b011
boundary condition: true
constant: false
is encoded by: hsa:AI373818
initial amount: NaN
has only substance units: false
name: _AI373818_1_m
type: Species
initial concentration: NaN
is: SBO:0000252

metaM ptth m
is: CHEBI:16753
name: pantetheine
is: SBO:0000247
initial concentration: 1.0
is: HMDB03426
type: Species
constant: false
boundary condition: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN
has only substance units: false

metaR AG13T14g
fast: false
modifier: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110046#_6867e9d5_92ac_49ce_8803_076d4601e185
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:10476
name: ATP5H
is: SBO:0000252
has only substance units: false
is: O75947
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_3bec261c_68e6_4a04_b6ca_ab15f2d4b447
name: GALNT14
initial amount: NaN
is: Q96FL9
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:79623

metaR TYRCBOX
name: L-Tyrosine carboxy-lyase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
reversible: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
reactant: MODEL1310110046#

metaM lpchol hs e
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:60479
name: lysophosphatidylcholine
has only substance units: false
initial concentration: 1.0

metaR FACOAL244 1
is: SBO:0000176
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
type: Reaction

metaR 10FTHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
reactant: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false

metaR PTDCACRNt
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
fast: false
reactant: MODEL1310110046#
reversible: false
name: pentadecanoate transport into the mitochondria
modifier: MODEL1310110046#

metaM dheas c
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:57905
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: SBO:0000247
has only substance units: false
is: HMDB01032

metaM 3octdece1coa c
type: Species
name: 3-hydroxyoctadecenoylcoa
is: C14143
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
is: HMDB04047
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM ksi pre34 g
is: HMDB00175
initial concentration: 1.0
is: CHEBI:58053
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
has only substance units: false
is: C00130
boundary condition: false
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 34
constant: false
is: SBO:0000247

metaR ATPtm
is described by: ECO:0000269
reactant: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false
reversible: false
name: ADP/ATP transporter, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110046#

metaR O2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
name: O2 transport (diffusion)
product: MODEL1310110046#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_6c2da307_1a26_485c_872a_f8764048af8a
initial amount: NaN
constant: false
is encoded by: hsa:2348
is: SBO:0000252
name: FOLR1
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_d35a66f7_8e08_49e0_91a6_25fd2d748cf4
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: TXNRD1
is encoded by: hsa:7296
type: Species
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_066a0cc6_edda_4840_9af0_a27a26b87d41
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:231
constant: false
name: AKR1B1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P15121

metaR G5SDym
type: Reaction
reversible: false
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.2.1.41
modifier: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
reactant: MODEL1310110046#
name: glutamate-5-semialdehyde dehydrogenase (m)

metaM 3aib e
is: CHEBI:33094
constant: false
has only substance units: false
type: Species
is: HMDB02166
name: (S)-3-aminoisobutyric acid
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial concentration: 1.0

metaM octdececrn c
constant: false
type: Species
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
is: HMDB06351
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
boundary condition: false
initial amount: NaN

metaR C226CRNt
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: C226 transport into the mitochondria

metaR 34HPLFM
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
name: 3-(4-hydroxyphenyl-)lactate formation
reversible: false
is described by: ECO:0000000
fast: false

metaR FAOXC16080m
kinetic law: MODEL1310110046#
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
type: Reaction
reversible: false
product: MODEL1310110046#

metaR CSND
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
name: Cytosine deaminase
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#

metaR LCADi D
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
name: lactaldehyde dehydrogenase
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304
product: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
reversible: false

metaM dgmp c
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57673
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
boundary condition: false
is: HMDB01044
is: C00362
initial amount: NaN
name: dGMP

metaM ksii core2 deg7 l
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: HMDB00812
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 7
notes: FORMULA: C44H73N4O30X CHARGE: 0
initial concentration: 1.0
is: CHEBI:16953
initial amount: NaN

metaM h2o x
is: C00001
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
has only substance units: false
is: CHEBI:15377
boundary condition: false
name: H2O
type: Species
is: HMDB02111
constant: false
is: SBO:0000247

metaR O2tn
reactant: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 nuclear transport
type: Reaction
product: MODEL1310110046#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_0dc1de48_6608_41d0_88c2_166ef3cc1150
constant: false
initial amount: NaN
name: UROC1
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:131669
boundary condition: true
is: Q68CJ7
has only substance units: false

metaM 3decdicoa m
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
name: 3,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110046#_388fedb3_677a_4651_ae67_0821c8d9c4ca
name: DPM2
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8818
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaM strdnc e
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205608
initial concentration: 1.0
constant: false
is: C16300
initial amount: NaN
is: HMDB06547
is: SBO:0000247
name: stearidonic acid C18:4, n-3

http://identifiers.org/biomodels.db/MODEL1310110046#_43d0d8d8_7282_40fc_8aee_a6d898e8b06d
name: COX5B
type: Species
boundary condition: true
constant: false
is: Q53YB7
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1329
has only substance units: false

metaR SUBERCACT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_81db05cf_ccb8_497f_8dc6_b9c9f7269ebd
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
has part: P56134
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
is encoded by: hsa:522
boundary condition: true
type: Species

metaR SO4t4 2
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
fast: false
reversible: true
name: sulfate transport via sodium symport
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_7e7941b2_f612_4424_a385_ddb93bed835f
initial amount: NaN
constant: false
is: P22392
name: NME2
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4831
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_fe38caf9_fae4_4393_9789_64cb5e7ff37c
initial amount: NaN
is encoded by: hsa:1644
is: SBO:0000252
has only substance units: false
boundary condition: true
name: DDC
initial concentration: NaN
constant: false
is: Q53Y41
type: Species

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_8dfa4f9c_a0c4_468f_bf06_7e2345fa28b7
constant: false
type: Species
is encoded by: hsa:7001
initial concentration: NaN
name: PRDX2
boundary condition: true
has only substance units: false
is: P32119
is: SBO:0000252
initial amount: NaN

metaR C6CRNtcx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaM eicostetcrn m
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01356
initial concentration: 1.0
type: Species
name: Eicosatetranoyl carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
boundary condition: false
is: CHEBI:57312

metaR FUCASE2e
reactant: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
modifier: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, extracellular
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_fc78214a_bc6c_4921_8e39_78e2e30fcfc4
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: O94788
is: SBO:0000252
name: ALDH1A2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8854

metaM 4fumacac c
is: HMDB01268
type: Species
initial concentration: 1.0
is: CHEBI:18034
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
has only substance units: false
initial amount: NaN
name: 4-fumarylacetoacetate(2-)
constant: false
boundary condition: false
is: SBO:0000247

metaR RE3301C
is version of: http://identifiers.org/ec-code/3.1.4.4
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
name: RE3301
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_abf003da_b1db_4bbf_a342_d883338c8bb9
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AA526438
name: _AA526438_1_c
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_c1f4697f_099c_49f5_8fbb_ae8204077e38
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6582
name: SLC22A2
initial concentration: NaN
is: O15244
initial amount: NaN
type: Species

metaM udpacgal l
type: Species
is: HMDB00304
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
initial concentration: 1.0
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN

metaR r1660
reversible: true
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110046#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_2caf2af7_ff13_4e36_aebd_0c152c81467c
is encoded by: hsa:158
is: SBO:0000252
name: ADSL
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: P30566
initial amount: NaN
constant: false

metaM cholcoar r
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
constant: false
is: HMDB02178
is: CHEBI:58677
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

metaM so4 e
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
type: Species
is: SBO:0000247
name: sulfate
boundary condition: false
is: HMDB01448

metaR r0698
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.27
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16

metaR SPODM
is described by: ECO:0000269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
name: superoxide dismutase
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110046#
reversible: false
type: Reaction
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_38229a6a_cbdb_4849_94b8_3bfe2bf667fd
initial concentration: NaN
is encoded by: hsa:2592
constant: false
is: B4E097
type: Species
has only substance units: false
initial amount: NaN
name: GALT
boundary condition: true
is: SBO:0000252

metaR FAOXC122x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_3405e3ee_1be2_4ef0_b3b6_1faae4957d7f
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: GALT
is: B2RAT6
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:2592
constant: false

metaR GLCNACASE2ly
reversible: false
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110046#_f110f4e6_b98e_4525_aa96_8274a2b2c0e8
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC25A18
initial concentration: NaN
has only substance units: false
is encoded by: hsa:83733
boundary condition: true
is: Q9H1K4
constant: false

metaR G14T3g
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_24b31c26_90c3_4939_bcee_0571466632e1
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10587
constant: false
name: TXNRD2

http://identifiers.org/biomodels.db/MODEL1310110046#_bf2a0b17_ceaf_40f4_8ab8_869b2e76d6ab
is: SBO:0000252
name: DGKE
type: Species
is: A1L4Q0
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8526
boundary condition: true
constant: false

metaM sphgn c
is: CHEBI:57817
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00269
type: Species
constant: false
name: sphinganine(1+)
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_233a99d6_6ba4_44d3_a90f_3742a4d3fde4
is encoded by: hsa:3418
is: P48735
initial concentration: NaN
is: SBO:0000252
name: IDH2
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_217ec46d_865a_4670_a9ad_1e8c886da387
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6342
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: SCP2
is: C9JC79

http://identifiers.org/biomodels.db/MODEL1310110046#_0e44d1d3_79b5_4a1e_b28e_937adaa89f78
has only substance units: false
type: Species
is encoded by: hsa:2109
boundary condition: true
is: SBO:0000252
name: ETFB
initial amount: NaN
initial concentration: NaN
constant: false

metaR GUAPRT
reactant: MODEL1310110046#
fast: false
name: guanine phosphoribosyltransferase
kinetic law: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
type: Reaction
product: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000269

metaM decdp m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB06288
has only substance units: false
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
type: Species
name: all trans Decaprenyl diphosphate

metaM lnlncacrn c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB06319
constant: false
name: alpha-linolenyl carnitine
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_a3ce456c_dad5_410c_93af_1720e88607f0
is: A7E2E0
initial concentration: NaN
is encoded by: hsa:5293
constant: false
has only substance units: false
type: Species
boundary condition: true
name: PIK3CD
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_aeee745a_bcc1_4f75_8251_f5cb8c24fbbc
boundary condition: true
type: Species
initial amount: NaN
is: Q13232
has only substance units: false
name: NME3
is encoded by: hsa:4832
constant: false
is: SBO:0000252
initial concentration: NaN

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM Ssq23epx r
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01188
name: (S)-2,3-epoxysqualene
is: CHEBI:15441
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_ad90a319_5937_4b6c_bfc5_d81624ffd868
has only substance units: false
constant: false
type: Species
is encoded by: hsa:249
is: B7Z4Y6
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ALPL
initial concentration: NaN

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_bc15f75f_15d2_42fe_a16a_87190e5aa1c2
initial concentration: NaN
is encoded by: hsa:4694
is: Q6IBB5
type: Species
has only substance units: false
constant: false
name: NDUFA1
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM HC00460 c
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: 2,5-dihydroxybenzoate
is: SBO:0000247
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
is: CHEBI:58044
boundary condition: false
initial concentration: 1.0

metaM 3octdece1coa m
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial amount: NaN
boundary condition: false
constant: false
name: 3-hydroxyoctadecenoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355

metaR NACHEX27ly
product: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD

metaM udpacgal g
boundary condition: false
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00304

metaR r0276
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
fast: false
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
reversible: true
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_7b009274_49e4_4507_b957_a6033b86b3fb
is: O14521
name: SDHD
initial concentration: NaN
is encoded by: hsa:6392
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_8401360d_9912_4472_8042_9661a90d50fa
initial concentration: NaN
name: NDUFS1
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: P28331
is encoded by: hsa:4719
boundary condition: true

metaM strdnc r
name: stearidonic acid C18:4, n-3
initial amount: NaN
type: Species
has only substance units: false
is: HMDB06547
initial concentration: 1.0
constant: false
is: C16300
is: http://identifiers.org/pubchem.compound/47205608
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793

metaR FAOXC204184m
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
reversible: false
fast: false
name: Beta oxidation fatty acid

http://identifiers.org/biomodels.db/MODEL1310110046#_144a5af5_55b3_4cdd_8be5_71bbfca81f7f
boundary condition: true
initial concentration: NaN
constant: false
is: P42765
has only substance units: false
name: ACAA2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10449
type: Species

metaM ksi deg11 l
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 11
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: HMDB00143
constant: false
type: Species

metaM Nacasp c
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00812
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: CHEBI:16953
name: N-acetyl-L-aspartate(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_ab4dd7ae_31f3_4832_b933_a942e762e2c6
initial amount: NaN
is: Q9BX95
boundary condition: true
name: SGPP1
type: Species
is encoded by: hsa:81537
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR DMHPTCRNte
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
reversible: true
name: 2,6 dimethylheptanoyl carnitine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ

http://identifiers.org/biomodels.db/MODEL1310110046#_81ab2406_e2dc_413d_9368_cd76def9351e
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ST20
type: Species
boundary condition: true
is: Q9HBF5
has only substance units: false
is encoded by: hsa:400410
constant: false

metaM so4 c
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01448
is: CHEBI:16189
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN

metaR FADH2ETC
is described by: ECO:0000134
kinetic law: MODEL1310110046#
fast: false
name: Complex II reaction for respiratory chain
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_afd5b19f_346c_4c49_a249_a8fca96a88c7
has only substance units: false
is: Q308M7
type: Species
name: ENPP3
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5169
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_b05188aa_6f83_42ac_b272_9bc9158d0bfd
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: IDI2
boundary condition: true
is: Q9BXS1
constant: false
is encoded by: hsa:91734

metaM m5mpdol L r
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37634
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR S6TASE12ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#

metaM cholcoar x
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial concentration: 1.0
is: HMDB02178
is: CHEBI:58677
initial amount: NaN

metaR RE0344C
is: SBO:0000176
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: RE0344
reversible: true
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_2b121c48_e607_4d17_99f9_7d5740c86629
has only substance units: false
type: Species
name: _NOS2A_1_e
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:NOS2A

metaR DLNLCGCRNt
product: MODEL1310110046#
fast: false
is: SBO:0000185
reactant: MODEL1310110046#
name: transport into the mitochondria (carnitine)
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110046#

metaR UPP3S
reversible: false
fast: false
name: uroporphyrinogen-III synthase
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.2.1.75

http://identifiers.org/biomodels.db/MODEL1310110046#_82651330_885a_4ab8_8b35_7afad7c6e307
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q75T13
is: SBO:0000252
name: PGAP1
is encoded by: hsa:80055
initial concentration: NaN
constant: false
type: Species

metaM cbp m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CH2NO5P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00164 EHMN_ABBREVIATION: C00169
name: Carbamoyl phosphate
is: CHEBI:58228
is: C00169
is: HMDB01096
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM hs deg13 l
initial amount: NaN
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 13
is: SBO:0000247
type: Species
is: CHEBI:17180
constant: false
is: HMDB01352

metaR TPI
is described by: ECO:0000134
kinetic law: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is version of: http://identifiers.org/ec-code/5.3.1.1
product: MODEL1310110046#
type: Reaction
name: triose-phosphate isomerase
reversible: true

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_3473bcad_09c2_4d53_8f81_7188249e6fd9
initial amount: NaN
type: Species
is encoded by: hsa:8821
boundary condition: true
is: O15327
initial concentration: NaN
has only substance units: false
constant: false
name: INPP4B
is: SBO:0000252

metaM doco13ecoa x
is: SBO:0000247
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
initial amount: NaN
name: 13-docosenoylcoa
boundary condition: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
type: Species

metaR GNDer
name: phosphogluconate dehydrogenase, endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
kinetic law: MODEL1310110046#
reversible: false
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000

metaM em2emgacpail hs r
initial concentration: 1.0
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
type: Species
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
has only substance units: false
is: CHEBI:16240
is: HMDB03125
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_7ba25b0c_2ccb_43f6_a6f9_d05e91a25f16
is encoded by: hsa:2645
initial amount: NaN
is: P35557
type: Species
is: SBO:0000252
name: GCK
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaR NP1
name: nucleotide phosphatase
is described by: ECO:0000304
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_90a71cd9_f7e7_488f_aea6_00eb106c4ea9
is: SBO:0000252
boundary condition: true
name: HSD17B4
has only substance units: false
is: E9PB82
type: Species
initial amount: NaN
is encoded by: hsa:3295
constant: false
initial concentration: NaN

metaR r0488
fast: false
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
is described by: ECO:0000000
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34

metaM tetpent3coa c
is: C16167
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: tetracosapentaenoyl coenzyme A, n-3
has only substance units: false
initial amount: NaN

metaR CHOLATEt
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
is described by: ECO:0000269
product: MODEL1310110046#
fast: false
name: cholate transport via bicarbonate countertransport
modifier: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true

metaR GDPFUCtg
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
product: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
name: GDPFuc Golgi transport via CMP antiport

metaR DOCO13EFATP
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR r1877
product: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR LINKDEG4ly
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaM strdnc l
is: C16300
is: HMDB06547
is: http://identifiers.org/pubchem.compound/47205608
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial concentration: 1.0
has only substance units: false
name: stearidonic acid C18:4, n-3
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM nm2masn g
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C42H70N3O30X CHARGE: 0
initial amount: NaN
has only substance units: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
type: Species
is: C05884
constant: false

metaR CYSALANaEx
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000185
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_3e340a18_8fe1_4b26_a663_f037045cbfb6
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:51227
type: Species
boundary condition: true
is: SBO:0000297
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaM 3aib m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial amount: NaN
initial concentration: 1.0
is: CHEBI:33094
is: HMDB02166
name: (S)-3-aminoisobutyric acid
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM sgalside hs l
type: Species
is: SBO:0000247
name: sulfatide galactocerebroside
is: CHEBI:16349
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00904
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1667487b_61be_4b76_8138_c3024cb04022
constant: false
type: Species
is encoded by: hsa:AI222095
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _AI222095_1_e
is: SBO:0000252

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_d46c2dc1_5bcf_4907_8d7f_c55831de202a
is: Q7GXY8
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: COX1
is: SBO:0000252
constant: false
is encoded by: hsa:4512

http://identifiers.org/biomodels.db/MODEL1310110046#_a7ff013a_d64b_4168_8f10_2a5f1714695a
initial concentration: NaN
is: Q86YI5
is encoded by: hsa:1737
type: Species
name: DLAT
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7c51a194_633d_40b0_9ddc_b2894ae6bd1f
name: ASRGL1
is: SBO:0000252
is: Q7L266
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:80150
boundary condition: true
type: Species

metaM lnlncacoa c
is: HMDB06290
is: CHEBI:51985
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: alpha-Linolenoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809

metaM fald m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01426
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:16842
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde

metaM dhdascb c
is: CHEBI:58070
initial concentration: 1.0
has only substance units: false
is: HMDB01264
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
constant: false
type: Species
name: dehydroascorbide(1-)

http://identifiers.org/biomodels.db/MODEL1310110046#_6a4cb835_a64b_4155_87cc_ebe45e316528
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR NACHEX10ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
product: MODEL1310110046#
reversible: false

metaR DNDPt17m
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110046#
name: dUDP transport via dCDP antiport
type: Reaction
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_69f627e4_1620_488e_a9a6_decba82e144c
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ALDH1A3
boundary condition: true
is encoded by: hsa:220
constant: false
initial amount: NaN
is: P47895

http://identifiers.org/biomodels.db/MODEL1310110046#_67a7f2ef_0777_48d4_9fde_abeb73246bb4
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5805
initial amount: NaN
is: Q03393
is: SBO:0000252
name: PTS
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_cd0af908_df56_49f5_8558_2f010247af23
constant: false
has only substance units: false
is encoded by: hsa:7991
boundary condition: true
initial amount: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
type: Species
is: SBO:0000297

metaR FATP3t
modifier: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
name: fatty acid electroneutral transport
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
kinetic law: MODEL1310110046#

metaM udpacgal c
boundary condition: false
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
is: SBO:0000247
is: HMDB00304
has only substance units: false
is: CHEBI:57847
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_7883b10a_bd5c_4156_a93b_7418f2e3333b
initial concentration: NaN
type: Species
has part: P23921
name: RRM1:RRM2
is encoded by: hsa:6240
constant: false
has part: P31350
has only substance units: false
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:6241

metaM pro L c
is: HMDB00162
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
boundary condition: false
name: L-proline
initial amount: NaN

metaR FCLTm
product: MODEL1310110046#
name: Ferrochelatase, mitochondrial
reversible: false
modifier: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/4.99.1.1
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
is: SBO:0000176
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction

metaR PDX5PO
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
name: pyridoxine 5'-phosphate oxidase
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110046#

metaR FAOXC183C163Gm
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaR SQLSr
product: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
name: Squalene synthase
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#

metaM eicostetcrn c
initial concentration: 1.0
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57312
has only substance units: false
initial amount: NaN
name: Eicosatetranoyl carnitine
is: HMDB01356

metaM acnam l
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0
name: N-acetylneuraminate
is: HMDB00230
is: CHEBI:35418
constant: false
is: SBO:0000247
initial amount: NaN

metaM dhdascb e
is: HMDB01264
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
type: Species
is: CHEBI:58070
name: dehydroascorbide(1-)

http://identifiers.org/biomodels.db/MODEL1310110046#_cdacd1e8_f73f_4789_9567_f7dd9e36007b
name: ATP5F1
boundary condition: true
constant: false
has only substance units: false
is: Q08ET0
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:515

metaM 4mop m
initial amount: NaN
name: 4-methyl-2-oxopentanoate
boundary condition: false
is: CHEBI:17865
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00695

metaM 4mptnl m
initial concentration: 1.0
is: SBO:0000247
is: HMDB01318
initial amount: NaN
name: 4-methylpentanal
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
boundary condition: false
has only substance units: false
is: CHEBI:17998
constant: false
type: Species

metaR NADPHtru
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
reactant: MODEL1310110046#
name: NADPH transporter, endoplasmic reticulum
fast: false
type: Reaction

metaR HIStN1
reversible: true
modifier: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000185
name: Histidine transport (Na, H coupled)
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110046#
type: Reaction
fast: false
reactant: MODEL1310110046#

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
fast: false
type: Reaction
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000

metaR UMPKm
is described by: ECO:0000134
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
kinetic law: MODEL1310110046#
name: UMP kinase (mitochondrial, ATP)
reversible: true
is: SBO:0000176
product: MODEL1310110046#

metaR BUP2
reactant: MODEL1310110046#
type: Reaction
fast: false
is described by: ECO:0000269
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
kinetic law: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
modifier: MODEL1310110046#
product: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.6

http://identifiers.org/biomodels.db/MODEL1310110046#_3d1d9d1c_67c1_4039_9108_77a78e9c82db
initial concentration: NaN
is encoded by: hsa:5152
is: SBO:0000252
type: Species
name: PDE9A
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaR ACOAD10m
is: SBO:0000176
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110046#
is described by: ECO:0000269
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reversible: false
product: MODEL1310110046#
fast: false

metaR r1657
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#

metaM m6masnB2 g
boundary condition: false
constant: false
type: Species
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: CHEBI:30825
initial amount: NaN
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: HMDB00573
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1a027ce4_142c_4666_97ac_f592ea4aa548
is: SBO:0000252
is encoded by: hsa:3101
initial amount: NaN
has only substance units: false
name: HK3
type: Species
initial concentration: NaN
constant: false
is: P52790
boundary condition: true

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_24e1dd89_bc03_4b48_baa5_d1bc5629b9ca
constant: false
type: Species
boundary condition: true
is: Q02252
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ALDH6A1
is encoded by: hsa:4329
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f6a91325_1b57_49ce_a7da_49e5e2947adf
type: Species
is: SBO:0000252
is: P55084
is encoded by: hsa:3032
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: HADHB
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_93fa8471_8ba6_4946_ba22_41efc6f70be0
constant: false
is: SBO:0000252
name: ATP5F1
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:515

metaR GLCAASE4ly
fast: false
kinetic law: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
is described by: ECO:0000000
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
type: Reaction

metaR r0494
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
product: MODEL1310110046#

metaM 4mptnl c
is: SBO:0000247
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
boundary condition: false
constant: false
is: CHEBI:17998
initial amount: NaN
type: Species
is: HMDB01318
name: 4-methylpentanal
has only substance units: false
initial concentration: 1.0

metaM dcsptn1 c
type: Species
boundary condition: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5282848
constant: false
name: docosa-4,7,10,13,16-pentaenoic acid
is: SBO:0000247
has only substance units: false
is: HMDB13123

http://identifiers.org/biomodels.db/MODEL1310110046#_6d4ab975_ef24_470a_8068_f79da1e70b6d
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: AK1
is encoded by: hsa:203
is: P00568
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_eb63dcf2_bd0c_4fa4_b22e_2f93dc58b24f
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:8818
has only substance units: false
constant: false
has part: P37287
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5277
is: SBO:0000297

metaM fad x
constant: false
name: Flavin adenine dinucleotide oxidized
has only substance units: false
is: HMDB01248
is: CHEBI:16238
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
boundary condition: false

metaR TYRt
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
name: L-tyrosine transport
reversible: true
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_ddc3d207_5338_47cc_a292_61b15ac5d2f9
has only substance units: false
name: NDUFS8
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4728
is: SBO:0000252
constant: false
is: O00217
initial concentration: NaN

metaM nrpphr e
initial concentration: 1.0
name: Norepinephrine
initial amount: NaN
is: HMDB00216
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
is: SBO:0000247
constant: false
is: CHEBI:33569
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5f580d36_4986_4538_aae3_318a6dd61fd0
is encoded by: hsa:5150
name: PDE7A
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q13946
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_490c2dfe_f841_4103_8bc1_da8df1e32938
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AU149534
has only substance units: false
name: _AU149534_1_m
constant: false
type: Species

metaR r1658
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110046#
fast: false
type: Reaction
reactant: MODEL1310110046#

metaM f1a l
has only substance units: false
is: CHEBI:17151
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
is: HMDB02917
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
name: F1alpha

metaR MECOALm
type: Reaction
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176
product: MODEL1310110046#
fast: false
reversible: true
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_284efc2c_4222_4e31_a84d_ff3e0d19a404
constant: false
name: HSD17B3
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3293
boundary condition: true
is: P37058
initial amount: NaN

metaM ksi pre31 g
has only substance units: false
initial concentration: 1.0
is: HMDB00175
is: C00130
name: keratan sulfate I biosynthesis, precursor 31
is: CHEBI:58053
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_de707977_d723_4581_a84a_3c2234978de4
name: _AA419122_1_c
initial amount: NaN
type: Species
is encoded by: hsa:AA419122
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_6c3fa69c_e395_4fda_b80e_d9582f8f8dac
is: P30613
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5313
constant: false
is: SBO:0000252
initial amount: NaN
name: PKLR

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_4fa47df8_fcdb_480d_909c_aa09ba08d313
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6822
is: SBO:0000252
is: Q06520
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SULT2A1

metaM dhcholestanate r
initial concentration: 1.0
has only substance units: false
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00359
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577

http://identifiers.org/biomodels.db/MODEL1310110046#_5e74285a_98e9_4986_a3e2_d2b453af0a69
has only substance units: false
is: Q9UKG4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:26266
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: SLC13A4

metaR r1659
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR BILDGLCURt
kinetic law: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
reactant: MODEL1310110046#

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM pail4p hs n
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

metaM hs deg4 l
is: SBO:0000247
type: Species
name: heparan sulfate, degradation product 4
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16126

metaM dhea r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:28689
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00077
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one

http://identifiers.org/biomodels.db/MODEL1310110046#_737bb65d_34e9_4f1a_902c_f9b4af2c1bcb
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: O14939
is encoded by: hsa:5338
constant: false
initial concentration: NaN
boundary condition: true
name: PLD2

metaR NACHEXA21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
is described by: ECO:0000000
product: MODEL1310110046#

metaR r0829
is described by: ECO:0000000
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/4.1.1.37
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d61190ef_99b1_46f8_831a_56b447470889
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PPA2
is: SBO:0000252
is encoded by: hsa:27068

metaM nrpphr c
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
type: Species
has only substance units: false
is: CHEBI:33569
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Norepinephrine

metaM 2decdicoa x
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: 2,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
initial amount: NaN

metaM xu5p D c
is: SBO:0000247
boundary condition: false
name: D-xylulose 5-phosphate(2-)
is: CHEBI:57737
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: HMDB00868
initial amount: NaN

metaM ksii core2 pre1 g
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C33H53N3O23X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 1
is: CHEBI:28067
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN

metaM dag hs c
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:18035
boundary condition: false
constant: false
name: diglyceride
is: SBO:0000247

metaR S6T9g
modifier: MODEL1310110046#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM c226coa m
is: SBO:0000247
name: cervonyl coenzyme A
boundary condition: false
constant: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_c6d0dde5_d1af_4fec_8537_3f452680060e
is: SBO:0000252
name: PIK3C2B
has only substance units: false
initial amount: NaN
is encoded by: hsa:5287
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: O00750

http://identifiers.org/biomodels.db/MODEL1310110046#_e1078934_8421_4adc_b71b_07f22d1bfe13
constant: false
is encoded by: hsa:5244
type: Species
initial amount: NaN
initial concentration: NaN
name: ABCB4
has only substance units: false
is: SBO:0000252
is: P21439
boundary condition: true

metaM ksi deg7 l
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 7
is: CHEBI:16953
has only substance units: false
constant: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: HMDB00812
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM 3hpp m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16510
name: 3-hydroxypropionate
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: SBO:0000247
constant: false
type: Species
is: HMDB00700

http://identifiers.org/biomodels.db/MODEL1310110046#_e25a5e6e_c104_456e_90ce_8b6e0a380073
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:8706
name: B3GALNT1
is: SBO:0000252
is: Q49AT3
initial concentration: NaN
type: Species
constant: false

metaM itacon m
initial amount: NaN
has only substance units: false
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
constant: false
is: HMDB02092
is: CHEBI:17240
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_c12c2548_3933_44d9_b373_23d9ddd5ac6b
is: SBO:0000297
boundary condition: true
has only substance units: false
initial amount: NaN
name: DPM3:DPM1:DPM2
initial concentration: NaN
has part: O60762
constant: false
is encoded by: hsa:8813
type: Species
has part: O94777
has part: Q86TM7
is encoded by: hsa:8818
is encoded by: hsa:54344

http://identifiers.org/biomodels.db/MODEL1310110046#_3cdfd2ff_9cb1_4f27_a360_a9792c199b6d
is: SBO:0000252
is encoded by: hsa:54407
name: SLC38A2
constant: false
is: Q96QD8
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaM HC00361 c
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
has only substance units: false
name: sedoheptulose 1,7-bisphosphate(4-)
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:58335

metaR C6CRNe
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

metaM CE2839 e
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
is: C01936
boundary condition: false
initial amount: NaN
name: maltodecaose
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

metaM fald e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16842
is: HMDB01426
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
initial amount: NaN

metaR DOLPMT4 Uer
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110046#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110046#
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_99826887_2ec1_40ff_88f5_2e5d6226bf5e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: NMNAT3
has only substance units: false
constant: false
is encoded by: hsa:349565
type: Species
is: Q96T66
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_0bab54f7_f04f_4328_868f_cf210058920b
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:FLJ44968
name: _FLJ44968_1_m

metaM met L e
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
has only substance units: false
is: CHEBI:16643
boundary condition: false
initial amount: NaN
constant: false
name: L-methionine
is: SBO:0000247
type: Species
is: HMDB00696

metaM ksii core2 deg8 l
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 8
is: HMDB00143
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0

metaR ACNAMPH
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
name: N-Acetylneuraminate 9-phosphate phosphohydrolase

http://identifiers.org/biomodels.db/MODEL1310110046#_b2430fba_8334_4e5b_9681_c4ec4b2996fc
initial amount: NaN
has only substance units: false
is: Q9NYW8
constant: false
is encoded by: hsa:57786
name: RBAK
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM dag hs e
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: CHEBI:18035
initial concentration: 1.0
constant: false
name: diglyceride

http://identifiers.org/biomodels.db/MODEL1310110046#_c2f99128_ba56_436c_b442_04b0e7597d49
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:8399
constant: false
is: O15496
type: Species
name: PLA2G10
is: SBO:0000252
initial concentration: NaN

metaM CE2433 m
initial amount: NaN
is: CHEBI:57795
initial concentration: 1.0
constant: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

metaR TSTSTERONESULT
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
name: testosterone sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.14
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110046#_63149f8f_c3ce_42fa_82ec_ff7cedfea8f8
is encoded by: hsa:2585
has only substance units: false
boundary condition: true
name: GALK2
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q01415
type: Species

metaR r0497
reactant: MODEL1310110046#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
reversible: true

metaM hedepecoa m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
constant: false
is: HMDB02288
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 2,4,7,10,13-hexadecapentenoylcoa

metaR ALDD21
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
name: aldehyde dehydrogenase (pristanal, NAD)
is described by: ECO:0000304

metaM 2dp6mobq me m
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
is: CHEBI:50772
constant: false
has only substance units: false
boundary condition: false

metaM mmcoa S m
is: HMDB02310
boundary condition: false
name: (S)-methylmalonyl-CoA(5-)
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: SBO:0000247
has only substance units: false
is: CHEBI:57327

metaM acnam c
is: HMDB00230
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
is: CHEBI:35418

metaR HISyLATthc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR FACOAL2251
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
name: fatty-acid--CoA ligase

metaM lgnccoa c
initial concentration: 1.0
is: HMDB06526
constant: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: lignocericyl coenzyme A
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_bb110ffc_57df_46f3_a30d_227e6a75d361
is encoded by: hsa:3155
initial amount: NaN
name: HMGCL
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q6IBC0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_1c13482a_4b0c_4660_be9e_e75958bb88c8
is encoded by: hsa:6508
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLC4A3
initial amount: NaN

metaR IPDDIx
is: SBO:0000176
name: isopentenyl-diphosphate D-isomerase
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reversible: true
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/5.3.3.2

metaM CE1925 e
name: 3'-carboxy-alpha-chromanol
constant: false
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
has only substance units: false
is: SBO:0000247
is: CHEBI:57923
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM 4mptnl e
is: SBO:0000247
is: CHEBI:17998
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB01318
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
boundary condition: false
name: 4-methylpentanal
has only substance units: false

metaM dmnoncrn m
is: HMDB06202
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
type: Species
is: SBO:0000247
constant: false
name: 4,8 dimethylnonanoyl carnitine

metaM 4mop e
name: 4-methyl-2-oxopentanoate
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:17865
constant: false

metaR RE1135C
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110046#
name: RE1135
fast: false
reactant: MODEL1310110046#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110046#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110046#

metaM dcsptn1 e
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: docosa-4,7,10,13,16-pentaenoic acid
is: http://identifiers.org/pubchem.compound/5282848
has only substance units: false
initial concentration: 1.0
is: HMDB13123
constant: false
boundary condition: false

metaM met L c
has only substance units: false
is: HMDB00696
initial concentration: 1.0
boundary condition: false
is: CHEBI:16643
name: L-methionine
initial amount: NaN
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
is: SBO:0000247

metaR BAMPPALDOX
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
reversible: false
fast: false
is described by: ECO:0000212
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB

metaR FAOXC121C101m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaM dhcholestanate m
initial concentration: 1.0
is: HMDB00359
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
constant: false

metaM fald c
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: formaldehyde
type: Species
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: CHEBI:16842
is: HMDB01426

http://identifiers.org/biomodels.db/MODEL1310110046#_d1f79ee6_7358_4bec_b1ab_e72c90eb76bb
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:3295
name: HSD17B4
type: Species
is: E9PB82
has only substance units: false

metaM ksi pre29 g
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 29
initial amount: NaN
is: CHEBI:28067
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_b208c11b_faf5_41b6_9ca6_3d9187a8967d
is encoded by: hsa:6487
is: Q11203
constant: false
boundary condition: true
name: ST3GAL3
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_08b54be8_13ca_411f_adf2_6d2be6deccba
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P78382
type: Species
is encoded by: hsa:10559
has only substance units: false
constant: false
boundary condition: true
name: SLC35A1

metaR SPODMn
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase, nuclear
reversible: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaR NRPPHRtu
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110046#
is described by: ECO:0000269
name: Norepinephrine uniport
modifier: MODEL1310110046#
type: Reaction

metaR GRTTx
reversible: false
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.5.1.1
name: geranyltranstransferase
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ

metaR r1761
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
fast: false
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_ff139365_d2d6_4b9c_be57_42d17a0bc5e5
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:33
initial concentration: NaN
type: Species
name: ACADL
is: P28330
boundary condition: true
constant: false

metaR S6TASE11ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110046#
fast: false
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
is described by: ECO:0000000

metaR SERtN1
product: MODEL1310110046#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: Serine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534

metaR CRNrtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
name: reversible transport of L-Carnitine in peroxisome
is described by: ECO:0000134
reactant: MODEL1310110046#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#

metaM his L c
initial amount: NaN
is: HMDB00177
type: Species
constant: false
name: L-histidine
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
is: CHEBI:15971

metaM 4mop c
type: Species
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00695
constant: false
is: CHEBI:17865
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_5093308c_9400_4455_9541_ee892f70e9f4
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: NME1
type: Species
is encoded by: hsa:4830

metaR UGALNACtg
is described by: ECO:0000269
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
type: Reaction
name: UDP-GalNAc Golgi transport via CMP antiport
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_aa7cd437_b8e8_4150_a739_9da69ccc96b0
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23236
name: PLCB1
is: SBO:0000252
constant: false
is: Q9NQ66
boundary condition: true
type: Species
has only substance units: false

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial amount: NaN
boundary condition: false
is: HMDB00876
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28940
initial concentration: 1.0
name: calciol

http://identifiers.org/biomodels.db/MODEL1310110046#_46839550_dd9b_4619_bd9c_f5a8785cffbc
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:84532
type: Species
is: Q9NUB1
constant: false
has only substance units: false
name: ACSS1
is: SBO:0000252

metaM pydxn c
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: C00314
is: SBO:0000247
name: Pyridoxine
type: Species
is: HMDB00239
has only substance units: false
initial concentration: 1.0
is: CHEBI:16709
initial amount: NaN
constant: false
boundary condition: false

metaR r1650
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110046#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#

metaM 3decdicoa x
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
constant: false
boundary condition: false
name: 3,7-decadienoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247

metaR RE1573M
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
is: SBO:0000176
reactant: MODEL1310110046#
reversible: true
type: Reaction
product: MODEL1310110046#
name: RE1573
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:

metaR FACOAL160i
name: C160 fatty acid activation
is described by: ECO:0000269
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110046#
fast: false
reversible: false
kinetic law: MODEL1310110046#

metaR G6Pter
reactant: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
reversible: true
type: Reaction
fast: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD

metaM pro L m
is: HMDB00162
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
has only substance units: false
type: Species
constant: false
is: CHEBI:17203
initial amount: NaN

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR ALASERNaEx
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
type: Reaction

metaR DOLASNT Ler
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.119
modifier: MODEL1310110046#
fast: false
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_94a4b63b_c407_4e01_aa04_872276fc4803
constant: false
is: SBO:0000252
name: PCCA
type: Species
has only substance units: false
is encoded by: hsa:5095
initial amount: NaN
boundary condition: true
is: C9JPQ8
initial concentration: NaN

metaM strdnc c
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205608
is: C16300
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
name: stearidonic acid C18:4, n-3
has only substance units: false
is: HMDB06547
is: SBO:0000247

metaR r1651
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_99973b00_2429_4a11_a25f_be70b2fea8dc
is encoded by: hsa:55276
name: PGM2
constant: false
is: Q96G03
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_5a0d3ffb_0287_4931_b81a_073108e055e0
initial amount: NaN
name: SLC25A20
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:788
is: O43772
is: SBO:0000252
initial concentration: NaN
constant: false

metaM his L e
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: HMDB00177
is: CHEBI:15971
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR IDOAASE2ly
is described by: ECO:0000000
modifier: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
fast: false

metaM glu5sa m
is: CHEBI:17232
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: L-Glutamate 5-semialdehyde
is: HMDB02104
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: C01165

metaM c226coa c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
type: Species
constant: false

metaM 5adtststerone r
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16330
constant: false
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0

metaR r0822
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000

metaR 5ADTSTSTERONESte
fast: false
type: Reaction
product: MODEL1310110046#
name: sulfonated testosterone transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110046#
reversible: true

metaM vitd3 e
is: HMDB00876
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:28940
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: calciol

metaR CORE3GTg
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reversible: false

metaR r1652
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_b4d56340_b9c9_4556_b426_2d5c99b7b8a4
boundary condition: true
type: Species
name: STS
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:412
is: P08842
is: SBO:0000252
initial concentration: NaN

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR FAOXC123m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaM fgam c
constant: false
initial concentration: 1.0
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
type: Species
initial amount: NaN
is: CHEBI:58426
is: C04376
boundary condition: false
is: SBO:0000247
is: HMDB01308
has only substance units: false

metaR r0821
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
product: MODEL1310110046#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR 34DHXMANDACOX
reactant: MODEL1310110046#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false
kinetic law: MODEL1310110046#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
modifier: MODEL1310110046#
is: SBO:0000176

metaM ksi pre14 g
boundary condition: false
constant: false
type: Species
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 14
initial concentration: 1.0

metaR 3AIB Dtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
name: transport of 3aib_D into mitochondria
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110046#
reversible: true
fast: false
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_ee95b5c9_4221_41a3_aa65_699c1f98592c
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:341947
is: SBO:0000252
initial concentration: NaN
is: Q7Z4L0
name: COX8C

http://identifiers.org/biomodels.db/MODEL1310110046#_960ec6d8_5cf2_4248_aca2_a8387b66efb7
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI971036
name: _AI971036_1_x
type: Species
has only substance units: false

metaM dhcholestanate c
initial amount: NaN
has only substance units: false
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
is: SBO:0000247

metaR r1653
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110046#

metaR PTDCACRNCPT2
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000176
name: pentadecanoate transport into the mitochondria
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110046#
reversible: false
is described by: ECO:0000000

metaR DM ethamp r
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR NAGA2ly
product: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.49
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000000
name: N-acetylgalactosaminidase, alpha-
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ

http://identifiers.org/biomodels.db/MODEL1310110046#_be8bf0a3_5518_4773_9b7b_83d464037d15
is encoded by: hsa:956
name: ENTPD3
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: O75355

metaR HSD3B11
kinetic law: MODEL1310110046#
reversible: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

http://identifiers.org/biomodels.db/MODEL1310110046#_87394c17_6f02_4235_9a66_f4702904f085
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ECI2
initial amount: NaN
is encoded by: hsa:10455
constant: false
type: Species
boundary condition: true
is: O75521

metaM dag hs n
name: diglyceride
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:18035
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055

metaR ADSS
fast: false
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.3.4.4
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
name: adenylosuccinate synthase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_33c6524a_1dce_4ec2_8778_21401b24a500
type: Species
name: ACO1
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:48
is: P21399
is: SBO:0000252

metaR r1654
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#

metaR PTDCACRNCPT1
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000269
name: carnitine fatty-acyl transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110046#
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reactant: MODEL1310110046#

metaM dmnoncrn x
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB06202
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: 4,8-dimethylnonanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110046#_be67ae3e_5404_4ada_b3af_9e8d3330ef27
initial concentration: NaN
constant: false
boundary condition: true
name: PIGA
initial amount: NaN
type: Species
is encoded by: hsa:5277
is: SBO:0000252
has only substance units: false

metaM 1glyc hs e
initial amount: NaN
constant: false
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 1 acyl phosphoglycerol
is: CHEBI:58190
is: HMDB00224

metaR RBK
product: MODEL1310110046#
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: ribokinase
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.15
kinetic law: MODEL1310110046#

metaM acrn c
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57589
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
constant: false
is: SBO:0000247
name: O-acetylcarnitine
initial concentration: 1.0

metaR DM T antigen g
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_1df6a42b_a614_429d_a274_99e82fe0d70e
is encoded by: hsa:55229
initial amount: NaN
constant: false
has only substance units: false
name: PANK4
boundary condition: true
initial concentration: NaN
type: Species
is: Q9NVE7
is: SBO:0000252

metaR DTTPtn
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110046#
name: dTTP diffusion in nucleus
reactant: MODEL1310110046#
reversible: true

metaR r1655
type: Reaction
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_27cd2189_9869_4373_a8f1_9861b4fdc906
initial amount: NaN
is encoded by: hsa:5145
has part: Q13956
name: PDE6A:PDE6H:PDE6B
has part: P16499
has part: B7Z9T9
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:5158
constant: false
is: SBO:0000297
is encoded by: hsa:5149

metaR SPODMx
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase, peroxisome
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_71418ef7_07c6_478a_82fb_7bf7af20b757
name: SUCLG2:SUCLG1
is: SBO:0000297
boundary condition: true
has part: P53597
has part: Q96I99
constant: false
initial amount: NaN
is encoded by: hsa:8802
has only substance units: false
type: Species
is encoded by: hsa:8801
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_fa17be7c_0e79_4d87_9c94_0133547e4daa
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:3290
constant: false
type: Species
name: HSD11B1
boundary condition: true
initial concentration: NaN

metaR RETH2e
reactant: MODEL1310110046#
fast: false
product: MODEL1310110046#
reversible: false
name: retinyl ester hydrolase (11-cis), extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#

metaM so4 m
constant: false
boundary condition: false
is: HMDB01448
type: Species
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: SBO:0000247
name: sulfate
initial amount: NaN
has only substance units: false

metaR LCADi
is described by: ECO:0000304
modifier: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
name: lactaldehyde dehydrogenase
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is: SBO:0000176
product: MODEL1310110046#
type: Reaction

metaR MCCCrm
modifier: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
is: SBO:0000176
name: methylcrotonoyl-CoA carboxylase, mitochondrial
reversible: true
fast: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.4.1.4
is described by: ECO:0000269

metaR ITPtn
fast: false
type: Reaction
reactant: MODEL1310110046#
is: SBO:0000185
name: ITP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true

metaM Nacasp m
boundary condition: false
name: N-acetyl-L-aspartate(2-)
is: HMDB00812
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_fe65f5bb_9cd1_4a70_b438_35c915835256
is: SBO:0000252
name: ACAA1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q96CA6
initial amount: NaN
is encoded by: hsa:30

metaM doco13ecoa c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false
name: 13-docosenoylcoa
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false

metaR r1656
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110046#

metaR PTCRTD
name: diffusion of putriscine into the endothelial cells
is described by: ECO:0000134
kinetic law: MODEL1310110046#
reversible: true
fast: false
product: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.

metaR MMEm
modifier: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
name: methylmalonyl-CoA epimerase/racemase
fast: false
is described by: ECO:0000269
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/5.1.99.1
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
reversible: true
type: Reaction
reactant: MODEL1310110046#

metaM dcmp n
constant: false
is: CHEBI:57566
boundary condition: false
name: dCMP(2-)
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01202
initial amount: NaN
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaR PRPPS
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.6.1
fast: false
name: phosphoribosylpyrophosphate synthetase
reactant: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaM lac D e
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16004
name: (R)-lactate
is: HMDB01311
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR NDP7er
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000176

metaR TDCHOLAte
reactant: MODEL1310110046#
type: Reaction
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_17dfbb94_a923_4753_8b29_dec87c7993a2
is: P10619
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: CTSA
constant: false
boundary condition: true
type: Species
is encoded by: hsa:5476

metaM ca2 e
initial concentration: 1.0
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
constant: false
is: HMDB00464
has only substance units: false
is: SBO:0000247
boundary condition: false
name: calcium(2+)
type: Species
initial amount: NaN

metaR 5MTHFt
kinetic law: MODEL1310110046#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
modifier: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_03050f20_321e_4def_bec4_fcba616c38b3
constant: false
has only substance units: false
name: AOC2
type: Species
is encoded by: hsa:314
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX oagt3 hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GT3 (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_f438f940_6ff2_4d72_9678_ad9b16066b1a
type: Species
constant: false
name: _AA576959_1_c
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA576959

metaR C161CRNt
is: SBO:0000185
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
name: C161 transport into the mitochondria
kinetic law: MODEL1310110046#
type: Reaction
reversible: false

metaM hs deg3 l
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16126
is: SBO:0000247
name: heparan sulfate, degradation product 3
boundary condition: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
has only substance units: false

metaM 4nphsf e
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:35422
is: HMDB06492
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species

metaR APAT2rm
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000212
is: SBO:0000176
fast: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction

metaR SUCCTD
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM no e
is: HMDB03378
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
name: Nitric oxide
constant: false
has only substance units: false
is: CHEBI:16480
type: Species

metaR EX c10dc
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sebacoyl carnitine
type: Reaction

metaR C204CRNt
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
name: arachidonic acid transport into the mitochondria
fast: false
reversible: false
kinetic law: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport

metaR GALASE4ly
reactant: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110046#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110046#
type: Reaction
reversible: false
modifier: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM HC02202 c
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
has only substance units: false
is: CHEBI:57398
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f8480f09_0d48_4aa6_8f65_bf0a65c4cb07
is: Q9NPH0
is encoded by: hsa:51205
name: ACP6
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR GMPtn
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110046#
name: GMP nuclear transport
reversible: true
fast: false

metaM bhb c
initial concentration: 1.0
is: CHEBI:10983
has only substance units: false
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false
name: (R)-3-hydroxybutyrate
is: SBO:0000247
is: HMDB00011
type: Species
initial amount: NaN

metaR OCOAT1m
name: 3-oxoacid CoA-transferase
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
is described by: ECO:0000269
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
fast: false
type: Reaction
reversible: true
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.8.3.5

metaM gm3 hs g
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:60065
boundary condition: false
is: SBO:0000247
type: Species
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_e14c59c7_c28e_4b12_a9ff_84965ca39209
constant: false
is: Q6PXP3
name: SLC2A7
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:155184

metaR THYOXt2
name: T4 transport via facilitated diffusion
reactant: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
type: Reaction
fast: false
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000185

metaR FACOAL200
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110046#
reversible: true
name: fatty-acid--CoA ligase
type: Reaction
fast: false
kinetic law: MODEL1310110046#

metaM ksi pre8 g
name: keratan sulfate I biosynthesis, precursor 8
has only substance units: false
is: CHEBI:28067
initial amount: NaN
type: Species
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC183806m
name: Beta oxidation of fatty acid
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is: SBO:0000176
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#

metaM lac D c
has only substance units: false
name: (R)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: CHEBI:16004
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01311

metaM hs l
is: CHEBI:28815
type: Species
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
name: heparan sulfate, free chain
initial amount: NaN
is: SBO:0000247

metaM acrn x
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57589
is: HMDB00201
name: O-acetylcarnitine
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial concentration: 1.0

metaM CE2435 m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: trans,cis-deca-2,4-dienoyl-CoA
is: CHEBI:57795
boundary condition: false
type: Species
has only substance units: false
constant: false

metaM ca2 c
is: CHEBI:29108
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00464
boundary condition: false
name: calcium(2+)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species

metaM ksi deg31 l
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
has only substance units: false
is: CHEBI:16953
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 31
constant: false
type: Species
is: HMDB00812

http://identifiers.org/biomodels.db/MODEL1310110046#_bbeb4a8e_6971_46a3_bfd8_eb128d74f398
has only substance units: false
is: P11182
name: DBT
is encoded by: hsa:1629
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false

metaM tmndnccrn m
is: HMDB00235
boundary condition: false
is: CHEBI:0
is: SBO:0000247
initial amount: NaN
is: C00378
constant: false
name: Timnodonyl carnitine
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
type: Species
initial concentration: 1.0
has only substance units: false

metaM 4nphsf c
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate
is: SBO:0000247
is: HMDB06492
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:35422
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_5bb363d8_915c_49a3_a4a7_882bd3fd7bb5
name: MECR
boundary condition: true
has only substance units: false
is: Q9BV79
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:51102
is: SBO:0000252

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.137
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR AG13T15g
reversible: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reactant: MODEL1310110046#
is: SBO:0000176
modifier: MODEL1310110046#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaR SPODMe
is: SBO:0000176
modifier: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase, extracellular
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
reversible: false
fast: false

metaR THD1m
fast: false
is: SBO:0000185
reactant: MODEL1310110046#
name: NAD(P) transhydrogenase
type: Reaction
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.6.1.2
reversible: true
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
is described by: ECO:0000269
modifier: MODEL1310110046#

metaM orn c
is: SBO:0000247
boundary condition: false
is: C01602
is: HMDB00214
constant: false
initial amount: NaN
is: CHEBI:0
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
type: Species
initial concentration: 1.0

metaM dag hs r
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
is: CHEBI:18035

http://identifiers.org/biomodels.db/MODEL1310110046#_227aba2e_ce59_4c4e_b3bd_a17d67b7112c
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NIT2
initial concentration: NaN
is encoded by: hsa:56954
constant: false
initial amount: NaN
type: Species
is: Q9NQR4

metaR G14T4g
reversible: false
reactant: MODEL1310110046#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR PROD2m
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.8
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
name: Proline dehydrogenase (m)
product: MODEL1310110046#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
type: Reaction

metaR DINt
is: SBO:0000185
name: deoxyinosine transport via diffusion
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#

metaM dnad c
is: CHEBI:18304
is: HMDB01179
constant: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
type: Species
is: C00857
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Deamino-NAD+

metaM CE1944 c
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
initial concentration: 1.0
has only substance units: false
name: 1-pyrrolinium
is: SBO:0000247
type: Species
is: CHEBI:36781
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_473a4cd4_9c84_40e1_a3d3_d79742ae0ad0
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: B4E0V8
is encoded by: hsa:3034
name: HAL
initial amount: NaN
constant: false
boundary condition: true

metaM ksi deg12 l
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 12
constant: false
type: Species
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM ala B c
boundary condition: false
name: beta-alanine
is: HMDB00056
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
is: CHEBI:16958
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_0621a9d8_1f95_40b2_835c_68911b99e207
boundary condition: true
name: PIGA
has only substance units: false
constant: false
is: B3KUV7
is: SBO:0000252
is encoded by: hsa:5277
initial concentration: NaN
type: Species
initial amount: NaN

metaM prostgi2 c
boundary condition: false
is: CHEBI:57403
is: HMDB01335
name: prostaglandin I2(1-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN

metaM 34dhphe e
constant: false
is: SBO:0000247
is: HMDB00181
is: CHEBI:15765
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: L-dopa
boundary condition: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

metaR N2M2NMASNtly
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
name: n2m2nmasn transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
reversible: false
product: MODEL1310110046#
is described by: ECO:0000000

metaR FACOAL205
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_7cbb68c7_db31_44b2_93d3_8f643c504deb
has only substance units: false
name: PPT1
initial amount: NaN
type: Species
is: Q6FGQ4
is encoded by: hsa:5538
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_af550366_4e42_400f_82e2_8e0bf4eb5764
initial concentration: NaN
name: ABCB4
constant: false
is encoded by: hsa:5244
type: Species
initial amount: NaN
has only substance units: false
is: A4D1D5
boundary condition: true
is: SBO:0000252

metaR FAOXC1811603m
modifier: MODEL1310110046#
product: MODEL1310110046#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110046#
is described by: ECO:0000269
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false

metaM orn e
boundary condition: false
name: Ornithine
initial concentration: 1.0
is: CHEBI:0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
is: HMDB00214
type: Species

metaM i e
is: HMDB12238
is: CHEBI:16382
boundary condition: false
has only substance units: false
name: iodide
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN

metaR GLCNACPT L
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.15
is: SBO:0000176

metaR C4CRNe
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR FAOXC205C184x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_4087282e_b2b2_4655_bef1_151ed4f26e6c
name: SHMT1
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P34896
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:6470

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM ksii core2 deg9 l
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:12936
constant: false
is: HMDB00143
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 9
boundary condition: false

metaR r1464
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110046#
name: Active transport
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
fast: false
is: SBO:0000185

metaR r1671
reactant: MODEL1310110046#
reversible: true
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_6cba2772_f1ae_4116_9e60_406314295174
initial amount: NaN
initial concentration: NaN
has part: B4DP47
constant: false
is encoded by: hsa:594
is encoded by: hsa:1629
is encoded by: hsa:593
type: Species
has only substance units: false
boundary condition: true
name: DBT:DLD:BCKDHA:BCKDHB
is: SBO:0000297
has part: P21953
has part: P11182

metaM c226coa x
has only substance units: false
constant: false
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0

metaR FACOAL204
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
reversible: true
is described by: ECO:0000269
product: MODEL1310110046#
name: fatty-acid--CoA ligase
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#

metaM 5adtststerone e
type: Species
constant: false
initial concentration: 1.0
is: HMDB02961
boundary condition: false
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM ksi e
is: CHEBI:17268
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00211
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I

metaR GTMLTe
fast: false
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110046#
name: g-glutamyltransferase (e)
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
modifier: MODEL1310110046#

metaR SERGLYexR
name: L-Serine/Glycine reversible exchange
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
reversible: true
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304

metaR TYRATB0tc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the intestinal cells by ATB0 transporter
type: Reaction

metaR FACOAL203
product: MODEL1310110046#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000000
type: Reaction

metaM 20ahchsterol m
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
has only substance units: false
is: HMDB06283
initial amount: NaN
constant: false
is: CHEBI:1296
name: 20-hydroxycholesterol
boundary condition: false

metaR r1670
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110046#
type: Reaction
reversible: true
is: SBO:0000185

metaR DHPM2
name: dihydropyrimidinase (dihydrothymine)
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: false
is: SBO:0000176
type: Reaction
fast: false

metaM xol7a r
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: CHEBI:1296
constant: false
name: 20-hydroxycholesterol
initial amount: NaN
has only substance units: false
is: HMDB01496
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR PHYTt
reactant: MODEL1310110046#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110046#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110046#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM prostgi2 e
is: HMDB01335
is: CHEBI:57403
boundary condition: false
is: SBO:0000247
name: prostaglandin I2(1-)
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaR C226CPT2
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
name: C226 transport into the mitochondria
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR G6PDH1rer
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
product: MODEL1310110046#
reversible: true
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110046#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110046#_cc19ce5c_cd6f_4be9_8d04_6664ef151feb
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:57419
name: SLC24A3
boundary condition: true
type: Species
has only substance units: false
is: Q9HC58
initial concentration: NaN

metaR ADSK
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.25
product: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
name: adenylyl-sulfate kinase
is: SBO:0000176
reversible: false
reactant: MODEL1310110046#

metaR FAOXC123x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaR CHOLESTle
name: hydrolysis of cholesterol ester by cholesterol esterase
is: SBO:0000176
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.1.13
type: Reaction
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#

metaM no c
is: CHEBI:16480
initial amount: NaN
has only substance units: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
constant: false
initial concentration: 1.0
is: C00533
boundary condition: false
type: Species
is: SBO:0000247
name: Nitric oxide

metaM g3m8mpdol L r
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:37568
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
is: C00459
is: HMDB01342

metaR DHPM1
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
reactant: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
name: dihydropyrimidinase (5,6-dihydrouracil)
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.2.2
reversible: false

metaR r1466
reactant: MODEL1310110046#
is described by: ECO:0000000
name: EC:2.3.1.86
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction

metaR C226CPT1
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine C22:6 transferase
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV

metaM 5adtststerone c
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
initial concentration: 1.0
is: CHEBI:16330
is: HMDB02961
is: SBO:0000247
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_82a92840_911d_4ff0_9dcb_81e32f923138
constant: false
has part: F8W7V3
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:517
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
boundary condition: true
is encoded by: hsa:9551
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_c3680515_fa94_4e4a_8143_98c6695ae54d
is encoded by: hsa:5152
boundary condition: true
type: Species
has only substance units: false
constant: false
name: PDE9A
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM CE0785 m
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: SBO:0000247
name: cis,cis-myristo-5,8-dienoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57795
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9a283b22_7d97_40ca_8cd1_384f45a1570f
is: P37287
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PIGA
is encoded by: hsa:5277
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_7ec0a80c_1724_44ca_b43a_35f6eadf8058
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:23556
name: PIGN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR HESTRATRIOLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000185
name: hydroxylated estrogen derivative transport
type: Reaction
product: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000

metaR r0475
reactant: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000

metaM acrn m
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
is: HMDB00201
constant: false
initial amount: NaN
name: O-acetylcarnitine
type: Species
is: CHEBI:57589

metaR CSPG Btly
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: chondroitin sulfate B transport, extracellular to lysosome

http://identifiers.org/biomodels.db/MODEL1310110046#_8e4bdab2_e341_49eb_bc09_3cae7718a3d4
is: Q14032
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: BAAT
is encoded by: hsa:570
constant: false
has only substance units: false
boundary condition: true
type: Species

metaR r1302
fast: false
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
name: Vesicular transport
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR GMPtg
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
name: GMP transport (Golgi)
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaM core4 g
has only substance units: false
name: Core 4
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16478
type: Species
initial concentration: 1.0
notes: FORMULA: C24H40N3O15X CHARGE: 0

metaR PCHOLPm hs
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
name: choline phosphatase
reversible: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
kinetic law: MODEL1310110046#
fast: false

metaR FAOXC123C102m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR VD3
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
product: MODEL1310110046#
name: Vitamin D3 formation
is described by: ECO:0000134
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: true
type: Reaction
fast: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM cortsn r
is: HMDB02802
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
type: Species
has only substance units: false
initial concentration: 1.0
name: cortisone
constant: false
boundary condition: false
is: CHEBI:16962

http://identifiers.org/biomodels.db/MODEL1310110046#_56451a27_ca1b_4fef_b075_b3f7365b59aa
constant: false
is encoded by: hsa:3098
boundary condition: true
is: P78542
type: Species
name: HK1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_b773661c_94be_4475_8453_b62987127650
is encoded by: hsa:1109
type: Species
is: P17516
name: AKR1C4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_4ac5d093_20fb_45e6_8896_d032859e983e
initial amount: NaN
type: Species
initial concentration: NaN
is: P33316
is encoded by: hsa:1854
has only substance units: false
constant: false
name: DUT
boundary condition: true
is: SBO:0000252

metaM clpnd c
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB06528
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: clupanodonic acid
is: CHEBI:53488

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM 4mzym int2 r
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 4-Methylzymosterol intermediate 2
initial concentration: 1.0
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: HMDB06838
type: Species
boundary condition: false

metaM arachdcoa x
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
type: Species
is: CHEBI:57368
constant: false
has only substance units: false
is: HMDB06523
boundary condition: false
initial amount: NaN
name: arachidonoyl-CoA(4-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_3dd526dc_18f8_4039_937c_a53ae3dd9217
boundary condition: true
constant: false
initial amount: NaN
name: _AA502753_1_m
is: SBO:0000252
is encoded by: hsa:AA502753
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_0d786500_5067_4c7c_9468_3f701079a93d
initial amount: NaN
constant: false
name: GALT
is: SBO:0000252
is encoded by: hsa:2592
type: Species
is: B2RAT6
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM pail4p hs c
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:58178

metaR MELATNOX
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
is version of: http://identifiers.org/ec-code/1.14.13.48
reactant: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.14.1
reversible: false
modifier: MODEL1310110046#
name: Melatonin:NADP oxidoreductase
is: SBO:0000176
kinetic law: MODEL1310110046#

metaR NOt
kinetic law: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
product: MODEL1310110046#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#
name: NO transport (diffusion)
reversible: true

metaM oaa c
constant: false
boundary condition: false
is: SBO:0000247
name: Oxaloacetate
is: HMDB00223
is: CHEBI:3338
is: C00036
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_a6149458_4f70_4f58_8cb4_ca3b1c2e45b2
name: SDHD
is encoded by: hsa:6392
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: O14521

metaR FATP4t
name: fatty acid electroneutral transport
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000269
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_759501b7_e50f_4c4c_8dfb_4f151c29f127
name: MTHFD2L
is: Q9H903
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:441024
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_8c6393ad_37b6_49e0_b7c8_09fc3990f8ad
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: IDI1
type: Species
has only substance units: false
is: Q13907
is encoded by: hsa:3422
initial concentration: NaN

metaM gam6p c
initial concentration: 1.0
is: HMDB01254
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:12962
is: SBO:0000247
boundary condition: false
name: D-Glucosamine 6-phosphate
constant: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM ksi deg18 l
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 18
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
has only substance units: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110046#_c6be9002_0814_4ef6_935b_cbb1cf2f29ef
name: UCK1
has only substance units: false
type: Species
constant: false
is encoded by: hsa:83549
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q5JT09

http://identifiers.org/biomodels.db/MODEL1310110046#_47c5534f_1e01_499f_9a15_1985057d70f9
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q16836
name: HADH
constant: false
initial concentration: NaN
is encoded by: hsa:3033

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR r1992
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
modifier: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_b532ce27_d640_4d40_a44b_de9616815cbf
constant: false
has only substance units: false
is encoded by: hsa:3633
type: Species
name: INPP5B
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P32019

metaR FACOAL206
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110046#
reversible: true
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110046#

metaR SPODMm
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110046#
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110046#
fast: false
name: superoxide dismutase
is: SBO:0000176
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_77bdf5f2_6d23_43d7_8d4c_c9c4dd361632
initial amount: NaN
is encoded by: hsa:1718
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: DHCR24
is: Q15392
type: Species
constant: false

metaR HDD2COAtx
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: hdd2coa intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110046#

metaR CBR2
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.189
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
fast: false
name: Carbonyl reductase [NADPH] 1
type: Reaction

metaM Rtotalcoa c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16189
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: HMDB01448
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: R total Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110046#_9a5f1365_9b95_4554_8f67_bf47ccc01382
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:AI620219
initial amount: NaN
name: _AI620219_1_c

metaM dhcholestanate x
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
boundary condition: false
initial amount: NaN
is: HMDB00359
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16577
has only substance units: false
type: Species

metaM clpnd e
has only substance units: false
is: HMDB06528
constant: false
type: Species
boundary condition: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
is: CHEBI:53488
name: clupanodonic acid
is: SBO:0000247
initial amount: NaN

metaM i c
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB12238
initial concentration: 1.0
is: CHEBI:16382
constant: false
name: iodide
initial amount: NaN
boundary condition: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

metaR r1991
reversible: false
modifier: MODEL1310110046#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110046#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110046#_2e8c9179_b218_4cb7_a7c7_c6dc5eb7b241
initial amount: NaN
has only substance units: false
is encoded by: hsa:122970
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q8N9L9
name: ACOT4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_847bea77_6467_4b8f_b255_86f8ba292b0c
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: LDHAL6A
is encoded by: hsa:160287
has only substance units: false
type: Species
is: Q6ZMR3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_5adbce03_71bf_4969_854b_eb1f23aa7684
is encoded by: hsa:57818
has only substance units: false
is: SBO:0000252
boundary condition: true
name: G6PC2
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: E9PAX2

metaM CE2838 e
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
name: maltononaose
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110046#_12634d52_c7e2_46fc_b3e3_172ecaecb42c
type: Species
is encoded by: hsa:6520
name: SLC3A2
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P08195
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7e41a580_1f0f_4fd3_a7a6_f49163b350c4
type: Species
is encoded by: hsa:28231
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q96BD0
name: SLCO4A1
initial amount: NaN

metaM HC01412 m
is: SBO:0000247
has only substance units: false
name: trans-tetradec-2-enoyl-CoA(4-)
is: CHEBI:61405
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
constant: false
initial concentration: 1.0

metaR UMPKn
modifier: MODEL1310110046#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
fast: false
product: MODEL1310110046#
name: UMP kinase, nuclear
kinetic law: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR O2St
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110046#
is described by: ECO:0000000
name: superoxide anion transport via diffusion (extracellular)
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_eba661dd_26f8_43c6_978e_53458bf8ff6d
is encoded by: hsa:64841
is: Q96EK6
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: GNPNAT1
initial amount: NaN

metaM cs e deg4 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
type: Species
is: CHEBI:15748
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C31H46NO38S4 CHARGE: -5
has only substance units: false
is: HMDB00127
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_18037a66_661b_4983_a69e_7af045567b36
constant: false
name: SLC6A9
type: Species
initial amount: NaN
initial concentration: NaN
is: B7Z3W8
is encoded by: hsa:6536
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM acrn r
name: O-acetylcarnitine
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57589
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201

metaM omhpal r
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: HMDB06294
name: w-hydroxypalmiticacid
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H30O3 CHARGE: -1

metaR NACHEX12ly
type: Reaction
fast: false
kinetic law: MODEL1310110046#
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reactant: MODEL1310110046#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_0f88feb9_d739_4bb8_87a5_63f8366baf87
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110046#_a4ad3e80_edd6_4a0f_8df3_fdc3816d393e
has only substance units: false
is: A8K761
boundary condition: true
type: Species
is encoded by: hsa:4716
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: NDUFB10

http://identifiers.org/biomodels.db/MODEL1310110046#_d3ea68a9_f52e_4258_aa23_b15fd439f18a
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5296
constant: false
name: PIK3R2
initial concentration: NaN
is: O00459
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_4136081f_adc2_4844_8bb9_641703d9c1ae
type: Species
is encoded by: hsa:55650
is: SBO:0000252
is: Q9NUD9
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: PIGV
initial concentration: NaN

metaR STS1
product: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
name: Steryl-sulfatase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.2

metaR RE3074X
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110046#
name: RE3074
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_712e9961_695c_488f_8607_613f1d724d5c
is: P10746
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7390
constant: false
has only substance units: false
name: UROS

http://identifiers.org/biomodels.db/MODEL1310110046#_077fb7c1_55e7_40d6_bcdf_83d723af3bcb
constant: false
name: AKR1C4
initial amount: NaN
is encoded by: hsa:1109
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: P17516
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_9a4820bf_39f5_4ad2_8aba_513583ad2f43
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _AI924226_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:AI924226
constant: false
type: Species

metaM orn m
is: HMDB00214
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
name: Ornithine
constant: false
is: C01602
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:46912
initial amount: NaN

metaR DCSPTN1t
reactant: MODEL1310110046#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: fatty acid transport via diffusion
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_7f0d7666_c610_4200_9cb3_8521d93124af
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:11136
is: SBO:0000252
is: P82251
initial concentration: NaN
name: SLC7A9
boundary condition: true

metaR S6T3g
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR r0267
kinetic law: MODEL1310110046#
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.9
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction

metaR DPMVDc
kinetic law: MODEL1310110046#
is described by: ECO:0000134
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.1.1.33
type: Reaction
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110046#
name: diphosphomevalonate decarboxylase, cytosol
reactant: MODEL1310110046#

metaR O2ter
name: O2 transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR FK
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
modifier: MODEL1310110046#
name: Fucokinase
is version of: http://identifiers.org/ec-code/2.7.1.52
kinetic law: MODEL1310110046#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
fast: false
type: Reaction

metaR r1019
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
name: Postulated transport reaction

metaM sebcoa x
name: sebacoylcoa
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_f8c94269_3c5a_4c04_97c8_2f487b050291
name: AK4
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:205
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaR ACOAD8m
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
is described by: ECO:0000269
is: SBO:0000176
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.10

metaR r1301
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110046#
type: Reaction
name: Vesicular transport
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110046#

metaR VALt5m
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110046#
name: Valine reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110046#_1d074343_01b8_4ee7_9cbf_0fe08e88c4c6
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4645
boundary condition: true
is: SBO:0000252
name: MYO5B
has only substance units: false
type: Species
is: Q9H6Y6
constant: false

metaR DAG HSter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000185
name: diacylglycerol ER export
reversible: false
product: MODEL1310110046#
is described by: ECO:0000000
fast: false

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.1
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
modifier: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
fast: false

metaM bhb e
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
type: Species
is: HMDB00011
boundary condition: false

metaM arachdcoa r
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57368
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial concentration: 1.0
has only substance units: false
constant: false
name: arachidonoyl-CoA(4-)
is: HMDB06523
boundary condition: false

metaM zymst r
is: HMDB06271
constant: false
is: SBO:0000247
has only substance units: false
name: zymosterol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: CHEBI:18252
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_40777940_78d8_4d10_b55c_3596cea5f5f1
is encoded by: hsa:5148
type: Species
has part: P18545
has part: O43924
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:5147
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
boundary condition: true
is: SBO:0000297
initial concentration: NaN

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM HC01444 e
boundary condition: false
name: Galactosylglycerol
type: Species
has only substance units: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15754
is: SBO:0000247
constant: false

metaM glu5p m
constant: false
has only substance units: false
is: HMDB01228
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
name: L-Glutamate 5-phosphate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58274
initial amount: NaN
boundary condition: false
type: Species

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_a231d01a_e565_4c53_8af9_840efae50705
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:257068
name: PLCXD2
initial concentration: NaN
type: Species
is: Q0VAA5
has only substance units: false
boundary condition: true

metaR SARCStm
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110046#
fast: false
name: Sarcosine transport (mitochondrial)
reversible: false

metaR ARGtm
name: arginine mitochondrial transport via ornithine carrier
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_86664f20_5756_4009_8c64_7bc606418b3c
is encoded by: hsa:197258
boundary condition: true
has only substance units: false
is: Q8N0W3
is: SBO:0000252
initial concentration: NaN
type: Species
name: FUK
initial amount: NaN
constant: false

metaR r1776
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110046#
type: Reaction
reversible: false
modifier: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
fast: false

metaR M13N2Tg
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
modifier: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.101
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

http://identifiers.org/biomodels.db/MODEL1310110046#_9ffabeab_465c_4d18_a259_b6681a1f92b7
is encoded by: hsa:3712
type: Species
name: IVD
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: B3KVI7
initial amount: NaN

metaM HC01407 m
type: Species
initial amount: NaN
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial concentration: 1.0
is: SBO:0000247
name: (S)-Hydroxyhexanoyl-CoA
boundary condition: false
has only substance units: false
is: CHEBI:28276
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_32ea792c_3bbe_4d38_ac07_e0e94367576f
initial amount: NaN
name: PPA2
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110046#_da41fbaa_96f5_4919_94a0_1cdc4b88ad34
name: PPAP2A
initial amount: NaN
constant: false
is encoded by: hsa:8611
is: SBO:0000252
is: G3XA95
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaM prostge1 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57397
has only substance units: false
type: Species
is: HMDB01442
name: prostaglandin E1(1-)

metaR NTP3e
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
name: nucleoside-triphosphatase (GTP)
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_6dbc2953_d610_495e_943c_86c2a3a26fa4
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: Q08828
is encoded by: hsa:107
constant: false
name: ADCY1
has only substance units: false

metaM acmanap c
initial concentration: 1.0
is: CHEBI:58557
name: N-acetyl-D-mannosamine 6-phosphate(2-)
has only substance units: false
initial amount: NaN
is: HMDB01121
type: Species
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_ff8e70b1_0851_4175_8446_b782263359be
name: VNN3
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:55350

metaR r2106
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110046#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9b0bd9de_8541_40f0_a32d_6bb0b83177ca
boundary condition: true
is: SBO:0000297
is encoded by: hsa:3945
has part: P00338
name: LDHA:LDHB
constant: false
initial concentration: NaN
is encoded by: hsa:3939
has only substance units: false
initial amount: NaN
type: Species
has part: P07195

metaR r0480
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaR EX glygn2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaM peamn c
type: Species
initial amount: NaN
is: HMDB12275
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
boundary condition: false
name: 2-phenylethanaminium
is: CHEBI:225237
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaR GCHOLAtx
is: SBO:0000185
reversible: true
product: MODEL1310110046#
name: bile acid intracellular transport
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR FAOXC205C185m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaR r0817
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110046#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
reversible: true

metaR r0603
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.12

http://identifiers.org/biomodels.db/MODEL1310110046#_7bf2ed54_d958_44a4_9f71_ae1efbb7d9e2
is encoded by: hsa:92483
type: Species
has only substance units: false
is: Q9BYZ2
constant: false
name: LDHAL6B
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR r2107
type: Reaction
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110046#
is: SBO:0000185

metaM octa c
has only substance units: false
boundary condition: false
is: CHEBI:25646
is: HMDB00482
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C8H15O2 CHARGE: -1
initial amount: NaN
type: Species
name: octanoate (n-C8:0)
is: C06423

http://identifiers.org/biomodels.db/MODEL1310110046#_f77779f8_a081_4c40_a42c_f181df65bcf6
boundary condition: true
is encoded by: hsa:6547
is: B3KU59
name: SLC8A3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaR r2104
modifier: MODEL1310110046#
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR HSD17B42x
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
product: MODEL1310110046#
type: Reaction
is: SBO:0000176
reversible: false
name: hydroxysteroid (17-beta) dehydrogenase 4
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110046#_64f92e11_3aaf_46ac_9185_af861fc4159f
initial amount: NaN
type: Species
name: GALNT9
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9HCQ5
constant: false
initial concentration: NaN
is encoded by: hsa:50614

metaM gthrd m
name: glutathionate(1-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00125
is: CHEBI:57925
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial concentration: 1.0
boundary condition: false
constant: false

metaR r1669
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_4586b89d_afd7_41d2_82f4_11ea13530eed
name: PSAT1
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:29968
initial concentration: NaN

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR 3SALAASPm
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
name: cysteinesulfinate-aspartate mitochondrial shuttle
reversible: true
is: SBO:0000185
modifier: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
is described by: ECO:0000304
fast: false

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_3ace1ab8_557e_4a7b_a683_b5807a69a339
is: Q9P0J0
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: NDUFA13
is encoded by: hsa:51079
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_1073e7d4_8339_434f_892d_9827de6f21ca
is: Q8TBG4
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:64850
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: AGXT2L1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9717f830_02c5_4e74_b4f7_0c087565d33e
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:9963
initial concentration: NaN
boundary condition: true
is: Q9UHI7
name: SLC23A1
initial amount: NaN
constant: false

metaR r2105
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110046#
fast: false
reversible: true

metaR C2tcx
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaM octa e
name: octanoate (n-C8:0)
is: HMDB00482
is: C06423
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C8H15O2 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:25646
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_fa8662bc_501e_4184_bd15_888211ba29f7
is: E7ETH5
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: SLC13A2
boundary condition: true
is encoded by: hsa:9058
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_722d8a91_bc11_462e_90d8_3eebf4d63eea
initial concentration: NaN
has only substance units: false
name: ST3GAL1
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6482
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_647c9dc5_8cb6_45d1_ba8d_382c48040f6e
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: SLC17A4
constant: false
is encoded by: hsa:10050
is: Q9Y2C5
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_db0b6e36_5f23_489d_b7ba_857a936d9530
type: Species
boundary condition: true
has only substance units: false
name: MAN1A1
constant: false
is: P33908
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4121

metaR TDCHOLAtx
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
reversible: true
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110046#
is: SBO:0000185
fast: false

metaM arachdcoa m
initial amount: NaN
constant: false
name: arachidonoyl-CoA(4-)
boundary condition: false
is: CHEBI:57368
is: SBO:0000247
is: HMDB06523
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_413b7479_ecec_4b3f_92a6_a604bde9b33c
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: E7ET32
name: GALT
constant: false
has only substance units: false
is encoded by: hsa:2592
is: SBO:0000252

metaR COQ3m
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
product: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.1.1.114
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176
name: methyltransferase COQ3

metaR FAOXC123C102x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaR r1172
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110046#
name: EC:3.1.1.13
is described by: ECO:0000000

metaM ksi pre11 g
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 11
constant: false
boundary condition: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_0d6ce261_71c6_4dc6_a8a2_89e5a0ae4310
initial concentration: NaN
is encoded by: hsa:1891
type: Species
initial amount: NaN
is: SBO:0000252
name: ECH1
is: Q13011
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_c8c17a93_b099_484a_a39e_f594211fae68
initial concentration: NaN
type: Species
boundary condition: true
name: PHGDH
is: O43175
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:26227

metaR r2102
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110046#
is: SBO:0000185
reversible: true
modifier: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#

metaR MGSA2
reactant: MODEL1310110046#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
type: Reaction
reversible: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
name: methyglyoxylate synthase 2 (from g3p)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_cd379788_a5a3_4614_83e3_f9c59d5df1b9
boundary condition: true
type: Species
is encoded by: hsa:211
constant: false
is: P13196
initial amount: NaN
name: ALAS1
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR CYANt
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
name: Cyanide transport via diffusion (extracellular to cytosol)
reversible: true
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_0a79077d_6b60_49c6_aca3_6c2fe5039361
name: PLCD1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P51178
is encoded by: hsa:5333
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR NACHEXA13ly
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110046#
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_e547db93_77d2_45e4_819e_be7072f10ebe
type: Species
has only substance units: false
name: ALDH1A3
is: SBO:0000252
initial amount: NaN
is: P47895
constant: false
is encoded by: hsa:220
boundary condition: true
initial concentration: NaN

metaR FAOXC80
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000269
name: Beta oxidation of med/long chain fatty acid
kinetic law: MODEL1310110046#
reversible: false
is: SBO:0000176
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110046#

metaR SPH1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
type: Reaction
kinetic law: MODEL1310110046#
fast: false
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
name: sph1p transport
is: SBO:0000185

metaM pacald c
initial amount: NaN
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial concentration: 1.0
has only substance units: false
name: phenylacetaldehyde
is: CHEBI:16424
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06236

http://identifiers.org/biomodels.db/MODEL1310110046#_cb948567_1e3c_4a05_b9d5_b08174690289
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: O15254
is encoded by: hsa:8310
name: ACOX3

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM ala D e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: D-alanine
is: HMDB01310
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
constant: false

metaM n2m2nm l
is: HMDB00573
is: CHEBI:30825
initial amount: NaN
name: n2m2nmasn (w/o peptide linkage)
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C58H97N5O41 CHARGE: 0
has only substance units: false

metaR SUBERCROT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_d8bc3908_cea9_4fd4_b0c1_45aef64ca9ed
initial amount: NaN
constant: false
is encoded by: hsa:64078
name: SLC28A3
is: Q9HAS3
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_623d1c28_ca19_4cc5_97c9_119746f70643
is encoded by: hsa:27124
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: INPP5J
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaR r2103
fast: false
kinetic law: MODEL1310110046#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_4d1fc416_8171_43dc_b64c_dfe8cd4e774e
type: Species
initial amount: NaN
is encoded by: hsa:51809
has only substance units: false
constant: false
is: Q86SF2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: GALNT7

http://identifiers.org/biomodels.db/MODEL1310110046#_8093ad67_9142_4f1c_928a_ba1e53c6c4fe
initial amount: NaN
initial concentration: NaN
constant: false
name: ATP5L
type: Species
is: SBO:0000252
is encoded by: hsa:10632
boundary condition: true
has only substance units: false
is: O75964

metaR PPItm
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000134
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
type: Reaction

metaR r0483
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
product: MODEL1310110046#
reversible: true
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
fast: false
is: SBO:0000176

metaM abt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
name: L-arabinitol
initial amount: NaN
is: CHEBI:18403

http://identifiers.org/biomodels.db/MODEL1310110046#_b224c361_a732_41ec_9927_f8b8bb246c3f
constant: false
is encoded by: hsa:80270
initial concentration: NaN
is: Q9H2F3
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: HSD3B7

metaM prostge1 c
has only substance units: false
name: prostaglandin E1(1-)
constant: false
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0
initial amount: NaN
is: HMDB01442
boundary condition: false
is: SBO:0000247
type: Species

metaR MG3er
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is: SBO:0000176
fast: false
kinetic law: MODEL1310110046#
reversible: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_5c04d939_9863_4f6c_9343_f7b19a5a6bd8
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:1543
has only substance units: false
is: SBO:0000252
is: A0N0X8
initial concentration: NaN
name: CYP1A1

http://identifiers.org/biomodels.db/MODEL1310110046#_14d2fe91_4a26_4ed3_8ba7_93029a62f430
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: SRD5A1
is: SBO:0000252
is: P18405
is encoded by: hsa:6715

metaR r2100
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR HS3ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1
name: heparan-N-sulfatase, lysosomal
reversible: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
kinetic law: MODEL1310110046#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#

metaR MM5cg
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110046#
type: Reaction
reversible: false
modifier: MODEL1310110046#
is: SBO:0000176
fast: false
product: MODEL1310110046#

metaM octd11ecoa m
is: SBO:0000247
boundary condition: false
name: 11-octadecenoylcoa
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
type: Species
is: HMDB06294
initial concentration: 1.0

metaR r1177
product: MODEL1310110046#
is: SBO:0000176
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: EC:3.1.1.13
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:

metaR HXPRT
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
fast: false
kinetic law: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
product: MODEL1310110046#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.8

metaM CE0849 m
initial amount: NaN
is: CHEBI:57795
type: Species
name: cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_2827c857_8dae_4185_8e50_4e0a0fa2d773
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: Q96M32
is: SBO:0000252
name: AK7
is encoded by: hsa:122481
has only substance units: false
initial amount: NaN

metaM ptth c
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16753
is: HMDB03426
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM 56dura c
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00076
has only substance units: false
is: CHEBI:15901
name: 5,6-dihydrouracil
type: Species
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial amount: NaN
initial concentration: 1.0

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_95efab47_7e16_4051_8061_4728961934dd
has only substance units: false
name: B4GALT1
constant: false
initial amount: NaN
type: Species
is: P15291
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2683
boundary condition: true

metaM 5thf e
notes: FORMULA: C39H45N11O18 CHARGE: -6
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: HMDB06487
name: pentaglutamyl folate (THF)

metaM tdec4ecoa m
name: trans4decenoylcoa
initial concentration: 1.0
is: HMDB00672
constant: false
type: Species
initial amount: NaN
is: C08260
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM ala D c
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01310
boundary condition: false
name: D-alanine
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1

metaR FUCASEe
type: Reaction
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
name: alpha-fucosidase, extracellular
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.51
reversible: false
is: SBO:0000176
reactant: MODEL1310110046#

metaR 3MOPt2im
product: MODEL1310110046#
type: Reaction
fast: false
reactant: MODEL1310110046#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
kinetic law: MODEL1310110046#
is: SBO:0000185

metaR r0819
reversible: true
type: Reaction
product: MODEL1310110046#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110046#

metaR CITtam
reactant: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
name: citrate transport, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_9a71dfea_bb6a_436b_8a08_ac2e824dd51e
name: GAPDHS
initial concentration: NaN
is: O14556
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:26330
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_b5b108bf_5889_4354_b261_8191cff2559b
has only substance units: false
is encoded by: hsa:10195
is: SBO:0000252
constant: false
type: Species
name: ALG3
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR D LACt2
reactant: MODEL1310110046#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110046#
name: D-lactate transport via proton symport
product: MODEL1310110046#
fast: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaM 6hoxmelatn c
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
initial amount: NaN
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7954
name: 6-Hydroxymelatonin
type: Species
initial concentration: 1.0
constant: false
is: HMDB04081
is: SBO:0000247
is: C05643

metaR r2101
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000000

metaR HSAT2ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_4de4b127_1d51_4e09_a6da_93cf33a383c7
is encoded by: hsa:522
has part: P05496
has part: A0PJH2
is: SBO:0000297
is encoded by: hsa:521
has part: Q08ET0
type: Species
is encoded by: hsa:515
is encoded by: hsa:516
has part: P56385
has part: P46459
constant: false
is encoded by: hsa:4905
has part: O75964
is encoded by: hsa:10476
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:9551
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10632
has part: Q6IBB3

metaM dlnlcgcrn m
type: Species
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
constant: false
is: HMDB01311
initial concentration: 1.0
has only substance units: false
name: dihomo-gamma-linolenyl carnitine
boundary condition: false
is: CHEBI:16004
is: SBO:0000247
initial amount: NaN

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR IDOAASE3ly
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reactant: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110046#
reversible: false
name: alpha-L-iduronidase, lysosomal
type: Reaction
is: SBO:0000176

metaR CSNt
name: cytosine transport via facilated diffusion
is: SBO:0000185
type: Reaction
reactant: MODEL1310110046#
reversible: true
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_2330b5cb_641a_44a4_97e5_662ece29f47d
initial concentration: NaN
has only substance units: false
name: PDE8A
is encoded by: hsa:5151
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: O60658

metaR BTNDm
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
type: Reaction
reactant: MODEL1310110046#
name: biotinidase (biotin), mitochondrial
is: SBO:0000176
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: false
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110046#_61c6f2ec_60d9_4ff2_a919_400039a35120
initial amount: NaN
name: B3GNT8
type: Species
is encoded by: hsa:374907
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q7Z7M8

http://identifiers.org/biomodels.db/MODEL1310110046#_40bb43a1_6180_48e9_a219_b404c5e132a5
is: O43677
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:4717
constant: false
is: SBO:0000252
type: Species
name: NDUFC1
initial concentration: NaN

metaM ksii core2 pre2 g
is: SBO:0000247
is: HMDB00175
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 2
is: CHEBI:58053
is: C00130

metaM ptth e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1
boundary condition: false
is: CHEBI:16753
is: HMDB03426
name: pantetheine
initial amount: NaN
type: Species
constant: false

metaR 34DHPHEt
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269
name: 3,4-Dihydroxy-L-phenylalanine transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
reactant: MODEL1310110046#
reversible: true

metaR FTHFL
reversible: true
type: Reaction
name: Formate-tetrahydrofolate ligase
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_e3082d79_9b25_4990_a91b_5d9c3b262dc6
initial concentration: NaN
type: Species
initial amount: NaN
name: INPP5E
boundary condition: true
is encoded by: hsa:56623
has only substance units: false
constant: false
is: Q9NRR6
is: SBO:0000252

metaR DHCRD1
is: SBO:0000176
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reversible: false
kinetic law: MODEL1310110046#
name: dihydroceramide desaturase
is described by: ECO:0000269
reactant: MODEL1310110046#
type: Reaction

metaM gthrd c
is: HMDB00125
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
is: CHEBI:57925
is: C00051
name: Reduced glutathione
initial concentration: 1.0
type: Species

metaM mescon m
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:36986
name: Mesaconate
initial amount: NaN
is: HMDB00749
boundary condition: false
constant: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: SBO:0000247

metaM 3aib c
is: SBO:0000247
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial amount: NaN
name: (S)-3-aminoisobutyric acid
initial concentration: 1.0
is: HMDB02166
boundary condition: false
constant: false
is: CHEBI:33094
has only substance units: false

metaR r1664
is: SBO:0000185
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110046#
name: Y+LAT2 Utilized transport
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NDP10ex
name: nucleoside-diphosphatase (IDP), extracellular
is described by: ECO:0000269
reactant: MODEL1310110046#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
fast: false
product: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT

metaR FAOXC16180m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110046#
type: Reaction
fast: false
reactant: MODEL1310110046#
name: Beta oxidation fatty acid

metaM dlnlcgcrn c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
boundary condition: false
is: SBO:0000247
type: Species
name: dihomo-gamma-linolenyl carnitine
is: HMDB01311
is: CHEBI:16004
has only substance units: false
constant: false

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR PPItr
name: Diphosphate transporter, endoplasmic reticulum
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110046#_d06731a2_d1f1_42b6_b5de_b4571b2b18d5
is: Q9UG56
name: PISD
initial amount: NaN
constant: false
is encoded by: hsa:23761
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM phyt2ohcoa x
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01295
type: Species
is: CHEBI:57334
boundary condition: false
has only substance units: false
name: 2-hydroxyphytanoyl-CoA(4-)
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_c2730c4c_fcf8_4906_a648_88d94a7dc323
has only substance units: false
is encoded by: hsa:29920
name: PYCR2
initial concentration: NaN
initial amount: NaN
type: Species
is: Q96C36
boundary condition: true
constant: false
is: SBO:0000252

metaR TYRTAm
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.6.1.5
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
reversible: true
name: tyrosine transaminase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaR r1020
is: SBO:0000185
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_448911ad_ce3e_4980_b881_b1c1c0a10a9e
is encoded by: hsa:6713
initial amount: NaN
has only substance units: false
name: SQLE
constant: false
initial concentration: NaN
boundary condition: true
is: Q5HYI4
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_6a99c581_ff6b_4834_aa12_c525977ac5df
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q8TB61
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:347734
name: SLC35B2

metaM ksi g
constant: false
initial concentration: 1.0
is: HMDB01644
boundary condition: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate I
initial amount: NaN
is: CHEBI:17140
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species

metaR GALASE10ly
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110046#
name: beta-galactosidase, lysosomal

metaR 4HPRO LTte
kinetic law: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of trans-4-hydroxy-L-proline
reactant: MODEL1310110046#
is described by: ECO:0000134
reversible: true
fast: false
product: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_bf4b8def_5a2a_4786_ba7b_dc5ba0a10ab6
initial amount: NaN
is: SBO:0000252
is: A8K0T6
is encoded by: hsa:55512
initial concentration: NaN
name: SMPD3
has only substance units: false
type: Species
constant: false
boundary condition: true

metaR 3SPYRSPm
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
reversible: false
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
fast: false
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
is: SBO:0000176

metaR r1661
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksi pre28 g
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 28
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00175
is: CHEBI:58053
is: C00130
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_7f26e684_e073_4c58_97b9_70a95711e45d
initial concentration: NaN
is encoded by: hsa:4720
name: NDUFS2
type: Species
is: B7Z792
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaM omhpal c
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB06294
name: w-hydroxypalmiticacid
is: SBO:0000247

metaM gthrd e
constant: false
is: HMDB00125
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57925
name: glutathionate(1-)
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_542d6e53_f350_4a06_ab55_9d09f09b7345
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: B3KMA6
boundary condition: true
is encoded by: hsa:2181
has only substance units: false
type: Species
name: ACSL3

metaR TETPENT6t
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reversible: true
product: MODEL1310110046#
is: SBO:0000185
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110046#_b7113ec4_8b03_4967_8eac_f74c6f71df8a
is encoded by: hsa:3032
is: P55084
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: HADHB

metaM 34dhphe c
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: HMDB00181
is: SBO:0000247
name: L-dopa
is: CHEBI:15765
constant: false
boundary condition: false
initial amount: NaN

metaR r1662
modifier: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110046#

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaM retinal cis 13 r
constant: false
name: 13-cis-retinal
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06220
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
initial amount: NaN

metaR FAOXC164GC163m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_2e0a5d7e_2423_4e41_b48d_dbfce52bd5c4
is encoded by: hsa:389015
has only substance units: false
name: SLC9A4
constant: false
is: Q6AI14
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_b408d726_1ef6_4b70_b6e2_fb1e0bbd166c
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4722
name: NDUFS3
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O75489
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_493a33e6_7518_4b56_a3a9_2e3deb9a69b7
name: PLA2G2A
has only substance units: false
boundary condition: true
initial amount: NaN
is: P14555
is encoded by: hsa:5320
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaM CE1926 e
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
constant: false

metaR r2408
reactant: MODEL1310110046#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR NRPPHRSULT
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
name: Norepinephrine Sulfotransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1
type: Reaction

metaR TETTET6t
fast: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110046#
is: SBO:0000185
reversible: true

metaR DPCOAtl
fast: false
product: MODEL1310110046#
reversible: true
type: Reaction
name: dephospho-CoA transport from lysosome via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#

metaM nm4masn g
has only substance units: false
constant: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C05882
notes: FORMULA: C54H90N3O40X CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_1d769f09_3ed5_4db4_84b8_f29fcb0c6dbe
name: PDE9A
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252

metaR r1667
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110046#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_a70565b0_c794_41e6_9732_7627108ecaf7
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:23439
initial concentration: NaN
name: ATP1B4
is: Q9UN42
is: SBO:0000252
type: Species

metaM arachdcoa c
initial concentration: 1.0
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
is: HMDB06523
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57368
constant: false
has only substance units: false

metaR GTHDH
name: Glutathione dehydrogenase (dehydroascorbate reductase)
product: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_d52248e2_03bf_4c92_a75f_db56c4653fdc
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:5152
initial concentration: NaN
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110046#_1a363e24_2dc9_4b35_817a_d507cae49fa0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4729
is: P19404
constant: false
has only substance units: false
boundary condition: true
type: Species
name: NDUFV2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_a074cece_a0e0_4801_b7c5_5a78765f9261
has only substance units: false
type: Species
initial amount: NaN
name: ATP1B3
boundary condition: true
is encoded by: hsa:483
is: SBO:0000252
is: P54709
constant: false
initial concentration: NaN

metaM oaa m
is: CHEBI:16452
type: Species
name: Oxaloacetate
initial concentration: 1.0
is: C00036
has only substance units: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00223
initial amount: NaN

metaR L LACt2r
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110046#
reversible: true
name: L-lactate reversible transport via proton symport
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false

metaR r1668
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
fast: false

metaR r1459
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110046#
reversible: true
product: MODEL1310110046#
name: Transport reaction
is: SBO:0000185
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR r0813
modifier: MODEL1310110046#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
reactant: MODEL1310110046#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
product: MODEL1310110046#

metaR r1665
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110046#
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM docoscoa x
has only substance units: false
is: HMDB12930
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: docosanoylcoa
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
constant: false

metaR C6DCCACT
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_09048bc4_dbbf_461c_8684_d82f61caf117
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4548
is: Q99707
is: SBO:0000252
has only substance units: false
name: MTR
boundary condition: true

metaR C14STRr
kinetic law: MODEL1310110046#
name: C-14 sterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.70
is described by: ECO:0000134
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reversible: false
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
is: SBO:0000176

metaM CE2434 m
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: CHEBI:57795
constant: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434

metaM ksi l
is: SBO:0000247
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
constant: false
is: C00445
boundary condition: false
type: Species
is: HMDB01354
initial amount: NaN
is: CHEBI:57455
initial concentration: 1.0
has only substance units: false

metaR r0812
is described by: ECO:0000000
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110046#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
reversible: true
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:

metaM pd3 c
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: Previtamin D3
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial amount: NaN
boundary condition: false
is: HMDB06500

metaR ESTRADIOLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reversible: true
is: SBO:0000185
name: estradiol transport
fast: false
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_3389b4b9_ff40_466c_9926_13c724f2aeda
is: SBO:0000297
is encoded by: hsa:4830
initial concentration: NaN
name: NME1:NME2
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaR NDP7ex
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
product: MODEL1310110046#
type: Reaction
reversible: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Glycolaldehyde dehydrogenase
modifier: MODEL1310110046#
is described by: ECO:0000304
product: MODEL1310110046#
is: SBO:0000176
type: Reaction

metaR PPItx
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
reversible: true
type: Reaction

metaM xtsn c
name: xanthosine
constant: false
is: CHEBI:18107
has only substance units: false
type: Species
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
boundary condition: false
initial concentration: 1.0
is: HMDB00299
is: SBO:0000247
initial amount: NaN

metaM r5p r
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00618

http://identifiers.org/biomodels.db/MODEL1310110046#_8d48b6f1_12a7_4ea5_b1a3_247c44702e41
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:6487
name: ST3GAL3
initial concentration: NaN
constant: false

metaR NAHCO3 HCLt
fast: false
kinetic law: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
type: Reaction
name: bicarbonate transport (HCl/NaHCO3 exchange)
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
is: SBO:0000185

metaR r1666
fast: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true

metaR SLDx
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
modifier: MODEL1310110046#
name: L-sulfolactate dehydrogenase (NAD+)
fast: false
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.37

metaR ASCBt4
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: L-ascorbate transport via proton symport
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
type: Reaction
fast: false
is: SBO:0000185

metaM dtmp c
constant: false
type: Species
initial concentration: 1.0
name: dTMP
boundary condition: false
is: CHEBI:26999
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
is: C00364
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_3f8193cf_d6ec_4c53_a58b_b3a8b0b884e2
is encoded by: hsa:5207
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P16118
initial concentration: NaN
constant: false
name: PFKFB1

metaM pristanal c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
name: pristanal
is: CHEBI:49189
initial amount: NaN
constant: false
is: HMDB01958
is: SBO:0000247
type: Species
boundary condition: false

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_404cf5ba_0b5f_40d6_a2d5_2fdaec001412
constant: false
boundary condition: true
name: B4GALT1:LALBA
has part: P00709
is encoded by: hsa:3906
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000297
initial concentration: NaN

metaM saccrp L m
is: CHEBI:57951
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
is: HMDB00279
boundary condition: false
constant: false
has only substance units: false
type: Species
name: L-saccharopinate(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_e3979295_d321_4cc3_8361_48e0c0939cb0
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: ENTPD1
is: Q86VV3
type: Species
initial concentration: NaN
is encoded by: hsa:953

metaR LRAT
reactant: MODEL1310110046#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
name: Lecithin retinol acyltransferase
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.135
fast: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (9227.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14596594,PMID:1503811,PMID:15474300 NOTES:IT
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_348dd4f9_1ac8_4274_b5d3_09556dedb6bf
is: SBO:0000297
has part: Q6FIH7
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:516
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
boundary condition: true

metaR RAI2
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
name: retinal isomerase (9-cis)
reversible: true
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_18305528_540c_4c97_9081_89d8959a473c
boundary condition: true
has only substance units: false
name: ALDH3A1
is: P30838
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:218
initial amount: NaN
constant: false
type: Species

metaR S6T16g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
is: SBO:0000176
modifier: MODEL1310110046#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_2a8f700e_695c_4dff_b7c1_912237cbcc18
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23530
name: NNT
type: Species
initial amount: NaN

metaM vacccoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247
name: vaccenyl coenzyme A
is: HMDB06521
initial amount: NaN
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0

metaR ADPACTD
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_39c65644_f864_439c_ac10_f8fcf465a188
has only substance units: false
initial amount: NaN
is: P04745
name: AMY1A
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:276
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_4e370764_b7dc_445f_a362_0b1395d78b48
initial concentration: NaN
boundary condition: true
has only substance units: false
is: B7Z5T8
constant: false
initial amount: NaN
type: Species
name: CPT1B
is: SBO:0000252
is encoded by: hsa:1375

metaR RAI1
name: retinal isomerase (11-cis)
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_846550c8_3814_460d_a255_f3a4daa3fedb
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q01959
is encoded by: hsa:6531
constant: false
type: Species
boundary condition: true
name: SLC6A3
initial amount: NaN

metaM HC01118 r
initial concentration: 1.0
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
boundary condition: false
initial amount: NaN
constant: false
name: presqualene diphosphate(3-)
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57310

metaR NACHEX25ly
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110046#
reversible: false

metaM 3octdece1crn e
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C25H47NO5 CHARGE: 0
boundary condition: false
type: Species
is: HMDB12930
name: 3-hydroxy-octadecenoyl carnitine

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_abd9276b_4292_40cc_8405_ab45e719ac8a
has only substance units: false
is: SBO:0000252
is encoded by: hsa:522
type: Species
constant: false
name: ATP5J
initial concentration: NaN
is: P18859
boundary condition: true
initial amount: NaN

metaM ppp9 m
boundary condition: false
initial amount: NaN
is: CHEBI:36159
has only substance units: false
name: Protoporphyrin
is: SBO:0000247
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
is: HMDB00241
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_c2057405_90d6_493a_8b03_d3a35687f181
has only substance units: false
initial amount: NaN
is encoded by: hsa:644
constant: false
initial concentration: NaN
is: SBO:0000252
is: P53004
boundary condition: true
type: Species
name: BLVRA

http://identifiers.org/biomodels.db/MODEL1310110046#_d6473151_439b_401a_a8ad_c15432fc7d6c
has only substance units: false
is: SBO:0000252
constant: false
name: SCD5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:79966
type: Species
boundary condition: true
is: Q86SK9

metaR DOLMANP Lter
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110046#
name: dolichol-phosphate mannose flippase (liver)
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110046#

metaM r1p c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
constant: false
has only substance units: false
name: alpha-D-Ribose 1-phosphate
initial concentration: 1.0
is: CHEBI:57720
is: HMDB01489
is: C00442
boundary condition: false
type: Species

metaR FAOXC102m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM h2o2 x
is: CHEBI:16240
is: C00027
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: HMDB03125
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_8b731542_3097_4d1d_b5d7_57c033e07045
is: SBO:0000252
type: Species
is encoded by: hsa:1633
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: P27707
name: DCK

metaM ump c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00288
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: C00105
is: CHEBI:57865
initial amount: NaN
type: Species
has only substance units: false
name: UMP

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM HC01377 m
name: S-(3-Methylbutanoyl)-dihydrolipoamide
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:27462
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119

metaR S6TASE19ly
modifier: MODEL1310110046#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000

metaR ADA
reversible: false
reactant: MODEL1310110046#
name: Adenosine deaminase
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR

metaR FRDPtr
type: Reaction
product: MODEL1310110046#
fast: false
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110046#
reversible: true

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR LNLNCAt
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110046#_b2771893_e6eb_49cc_8226_49df642efb6c
is encoded by: hsa:50487
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9NZ20
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: PLA2G3

http://identifiers.org/biomodels.db/MODEL1310110046#_41328253_503e_440c_ad5c_fd576e544ffb
initial concentration: NaN
name: CA5A
initial amount: NaN
is encoded by: hsa:763
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P35218
constant: false

metaR RE3004M
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE3004
reversible: true
fast: false
is: SBO:0000176

metaR CRNt
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
name: L-carnitine reversible transport
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is: SBO:0000185
product: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_97543b94_b1b1_4e3f_9bbf_6c12983359e6
initial concentration: NaN
is: Q9BWD1
initial amount: NaN
is encoded by: hsa:39
is: SBO:0000252
constant: false
type: Species
name: ACAT2
has only substance units: false
boundary condition: true

metaM leu L e
name: L-leucine
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:15603
is: SBO:0000247
type: Species
constant: false
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR r2007
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#

metaM h x
is: http://identifiers.org/pubchem.compound/3380
constant: false
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: proton
is: C00080
initial amount: NaN
is: CHEBI:24636

metaR HAtly
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
type: Reaction
name: hyaluronan transport, extracellular to lysosome
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM acgal l
is: HMDB00212
name: N-acetyl-D-galactosamine
initial amount: NaN
is: CHEBI:28037
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaM elaidcrn m
name: Elaidic carnitine
is: HMDB06464
type: Species
constant: false
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_d16dfd1c_7b99_480b_8c19_0f3a13388a09
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: HAS3
initial amount: NaN
is: O00219
is encoded by: hsa:3038

http://identifiers.org/biomodels.db/MODEL1310110046#_b0b101e3_f14d_4582_85e3_3215302effbd
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI769281
name: _AI769281_1_e
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_261625a0_1eaf_4be3_a90c_44e062ed8525
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:218
has only substance units: false
is: SBO:0000252
name: ALDH3A1
initial concentration: NaN
is: P30838
boundary condition: true

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110046#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110046#
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110046#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110046#_a7ae8904_f4c2_4b9f_a986_25faf24ab630
constant: false
is: P15289
initial concentration: NaN
type: Species
is: SBO:0000252
name: ARSA
is encoded by: hsa:410
initial amount: NaN
has only substance units: false
boundary condition: true

metaM glyald c
is: HMDB01051
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: C00577
is: CHEBI:17378
name: D-Glyceraldehyde

metaM lneldccoa m
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
name: linoelaidyl coenzyme A
boundary condition: false

metaR RE1534M
reversible: true
is: SBO:0000176
reactant: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1534
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_33be2913_517c_4b51_ba4f_d544e87805fd
type: Species
is: Q01968
name: OCRL
initial amount: NaN
is encoded by: hsa:4952
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaR r0580
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is: SBO:0000176
product: MODEL1310110046#

metaM ump e
has only substance units: false
is: SBO:0000247
name: UMP(2-)
constant: false
initial concentration: 1.0
is: HMDB00288
boundary condition: false
is: CHEBI:57865
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR r2367
kinetic law: MODEL1310110046#
name: Organic anion transporter 5 Utilized transport
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaR OCBTm
reversible: false
modifier: MODEL1310110046#
name: ornithine carbamoyltransferase, irreversible
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5009.1) SUBSYSTEM: Urea cycle EC Number: 2.1.3.3 Confidence Level: 4 AUTHORS: PMID:12538786,PMID:6372096 NOTES:TDV
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.1.3.3
type: Reaction
fast: false

metaR 5HLTDL
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
kinetic law: MODEL1310110046#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28
reversible: false
product: MODEL1310110046#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_87f3aa12_1798_47ca_b2e3_18a7b73a9b09
is: SBO:0000252
has only substance units: false
name: _206_1_c
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:206
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_118e094e_6352_4763_9e01_3ffecac1aed9
constant: false
is: Q04828
type: Species
name: AKR1C1
is: SBO:0000252
is encoded by: hsa:1645
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_8c59af5d_4016_4e05_94b8_e8d7264bc5ca
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: ALDOA
is encoded by: hsa:226
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_353c363c_6a25_4506_9883_07b7f9043791
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:29124
boundary condition: true
is: Q9UHV8
is: SBO:0000252
constant: false
name: LGALS13
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_ad1e7e4f_8562_45f5_9126_59009dda602c
name: CCBL1
is encoded by: hsa:883
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q16773
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_f8b99b23_7f5b_4274_ac1f_f686887c459b
name: CA5B
is: Q9Y2D0
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:11238
type: Species

metaR PPAt
kinetic law: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
reversible: false
name: Propionate transport, diffusion
product: MODEL1310110046#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_16ef51e8_1ed4_46c5_8b14_603555338da1
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: CKMT1B
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1159
is: P12532

http://identifiers.org/biomodels.db/MODEL1310110046#_d8c7c518_dff5_476a_b9bf_7351b9e146da
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3162
is: Q6FH11
name: HMOX1
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_3af84dcd_710a_4cd9_8fbb_a10389fd18dd
name: CKMT2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:1160
is: P17540
type: Species

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_1bf4e153_f876_4646_aa1c_19e465b6b51d
is encoded by: hsa:6184
type: Species
name: RPN1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: P04843
initial amount: NaN

metaR CYStec
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
is: SBO:0000185
name: L-cysteine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269

metaR r2366
reversible: true
fast: false
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaR UMPK3n
name: UMP kinase (UTP),nuclear
modifier: MODEL1310110046#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110046#
is described by: ECO:0000269
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110046#

metaM dtmp e
has only substance units: false
is: CHEBI:26999
is: HMDB01227
name: dTMP(2-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
is: SBO:0000247
constant: false

metaR DHCR72r
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reversible: false
modifier: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: 7-dehydrocholesterol reductase
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.1.21

metaM c6dc c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247
is: HMDB00705
name: adipoyl carnitine
has only substance units: false
boundary condition: false
type: Species
constant: false

metaM pi x
type: Species
boundary condition: false
has only substance units: false
constant: false
name: hydrogenphosphate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
initial amount: NaN

metaR r2369
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_79a2734d_c424_4b5d_9677_465b9c7ccec8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: SLC26A4
constant: false
is: O43511
is encoded by: hsa:5172

metaR ORNALArBATtc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR PYDXDH
fast: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
name: pyridoxal dehydrogenase
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.3.1
kinetic law: MODEL1310110046#
reversible: false

metaM ump g
type: Species
is: HMDB00288
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
name: UMP(2-)
has only substance units: false
is: CHEBI:57865
boundary condition: false

metaR PHYCBOXL
kinetic law: MODEL1310110046#
reversible: false
is: SBO:0000176
name: L-Phenylalanine carboxy-lyase
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is described by: ECO:0000212
product: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_42274663_1cc0_4d09_9a07_e6a3e773ec27
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8395
constant: false
has only substance units: false
name: PIP5K1B
initial concentration: NaN
is: O14986
boundary condition: true

metaR THMP
name: thiamin phosphatase
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000176
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
reversible: false
kinetic law: MODEL1310110046#
type: Reaction

metaR HISSNAT5tc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_c9ac9818_dec0_4b30_a5ab_0078c5a6c6b4
initial amount: NaN
has only substance units: false
is: B4DIA3
name: SLC6A8
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6535
type: Species
boundary condition: true

metaR ACRNtm
fast: false
name: O-acetylcarnintine transport into mitochondria via diffusion
modifier: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_bebd5f39_aa17_4515_8c6c_7e0478ae36ac
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: GLUD1
is: E9KL48
is encoded by: hsa:2746
initial concentration: NaN

metaM 3octdece1crn c
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C25H47NO5 CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB04047
is: C14143
name: 3-hydroxy-octadecenoyl carnitine

metaM ocdececrn c
type: Species
initial amount: NaN
constant: false
name: 11-octadecenoyl carnitine
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
is: SBO:0000247

metaR ASPNATm
is: SBO:0000176
name: aspartate N-acetyltransferase, mitochondrial
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110046#

metaR PE HSter
is described by: ECO:0000000
name: phosphatidylethanolamine scramblase
kinetic law: MODEL1310110046#
reversible: true
fast: false
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reactant: MODEL1310110046#
type: Reaction

metaM bildglcur r
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
type: Species
is: HMDB03325
constant: false
has only substance units: false
is: SBO:0000247

metaR r2368
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110046#
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#

metaM 2docopencoa m
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
name: 2,7,10,13,16-docosapentenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110046#_fe6680a1_d06e_4038_beaf_0b26b0821c6d
is: Q9Y5B8
name: NME7
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29922
has only substance units: false
initial amount: NaN
type: Species

metaR r2363
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110046#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110046#

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaM retinol cis 11 e
is: SBO:0000247
is: HMDB06216
is: CHEBI:16302
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinol
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_be1347e8_3872_47a0_9fa0_e6d3c9f463fb
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: HAO2
has only substance units: false
is encoded by: hsa:51179
initial amount: NaN
boundary condition: true

metaR RE3347C
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: RE3347
reversible: true
reactant: MODEL1310110046#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_5ed05699_bd73_4d1a_9a78_1616ab8ad898
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4720
is: B7Z792
boundary condition: true
initial concentration: NaN
name: NDUFS2

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_38049bda_d024_47bb_9784_234a94b016b0
boundary condition: true
name: SLC6A2
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6530
initial concentration: NaN
is: Q96KH8
initial amount: NaN
is: SBO:0000252

metaR S4TASE2ly
reversible: true
fast: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
name: N-acetylgalactosamine-4-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110046#_836c2a6c_6eae_4250_a874_657658a4fbe7
boundary condition: true
is encoded by: hsa:53630
initial concentration: NaN
has only substance units: false
is: Q9HAY6
type: Species
constant: false
is: SBO:0000252
name: BCMO1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_bd7dbc10_fc36_47a3_9dd6_9d6e3303eab5
name: _AI480132_1_c
constant: false
boundary condition: true
is encoded by: hsa:AI480132
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR DPCOAPPe
is: SBO:0000176
fast: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110046#
reversible: false
name: Pyrophasphatase (dephospho-CoA, extracellular)
product: MODEL1310110046#

metaR r2362
is: SBO:0000185
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110046#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#

metaR r0472
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110046#
reversible: true
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110046#
is: SBO:0000176

metaR Q10H2e
is: SBO:0000185
product: MODEL1310110046#
kinetic law: MODEL1310110046#
name: transport of ubiquinol into lymph
reactant: MODEL1310110046#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

http://identifiers.org/biomodels.db/MODEL1310110046#_7da242a0_5308_4b05_ae6b_16d8f02cab29
is: SBO:0000252
is encoded by: hsa:2519
constant: false
is: Q9BTY2
name: FUCA2
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaR RE2349C
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
name: RE2349
type: Reaction
product: MODEL1310110046#
fast: false

metaM h r
name: proton
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:24636
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
is: C00080
is: SBO:0000247

metaR OCTAt
is: SBO:0000185
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110046#
name: Octanoate transport via diffusion
fast: false
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_b1988f86_4536_4a14_9d73_ae9bf577d659
initial amount: NaN
is: P49914
name: MTHFS
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:10588
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_3f69a521_2205_4cab_b038_1ff2ba5c5b0e
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:112
name: ADCY6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_0592021b_65fb_402d_8325_bad943c8d4e0
boundary condition: true
initial concentration: NaN
name: DPAGT1
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1798
has only substance units: false
constant: false

metaM tcynt e
has only substance units: false
name: thiocyanate
is: CHEBI:18022
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01453
constant: false

metaR DM atp c
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
reversible: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: DM_atp(c)
product: MODEL1310110046#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176

metaM tethex3coa c
constant: false
name: tetracosahexaenoyl coenzyme A
is: HMDB06243
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205478
initial amount: NaN
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
type: Species
is: C16168
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR PGK
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.2.3
kinetic law: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000134
name: phosphoglycerate kinase

metaR GLCAASE1ly
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110046#
reversible: false
fast: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR r2365
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110046#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110046#_4c40c716_463b_4ac8_96e3_fdd5534edbbb
is: Q9P212
is encoded by: hsa:51196
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: PLCE1

metaR S6TASE14ly
is: SBO:0000176
reversible: true
modifier: MODEL1310110046#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false

metaR r0734
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
product: MODEL1310110046#
reversible: false
is: SBO:0000176
reactant: MODEL1310110046#
is described by: ECO:0000000

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_6f5702c1_59f9_4bc7_bc62_386b77137fdc
has only substance units: false
name: SLC38A5
is encoded by: hsa:92745
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: Q8WUX1
constant: false

metaR r0474
reversible: true
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110046#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR r2364
is: SBO:0000185
reversible: true
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false

metaM CE2417 m
initial concentration: 1.0
is: HMDB11123
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial amount: NaN
is: CHEBI:28387

metaR RE1898C
fast: false
product: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110046#
name: RE1898

metaM bhb m
type: Species
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00011
is: SBO:0000247
constant: false
is: CHEBI:10983
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7bb81ecf_4d3f_4443_ac88_50d39fd0c15c
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: P15309
is encoded by: hsa:55
is: SBO:0000252
type: Species
name: ACPP

metaR r0735
is: SBO:0000176
reactant: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR PYK
product: MODEL1310110046#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
reversible: false
kinetic law: MODEL1310110046#
is: SBO:0000176
name: pyruvate kinase

metaM dec24dicoa x
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 2,4-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: HMDB01168
boundary condition: false
type: Species
initial amount: NaN

metaM vacccoa c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/9543677
constant: false
type: Species
is: HMDB06521
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
name: vaccenyl coenzyme A

metaM tcynt c
is: HMDB01453
name: thiocyanate
constant: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: CHEBI:18022
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaR RE1448N
is described by: ECO:0000000
name: RE1448
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: true
reactant: MODEL1310110046#
fast: false
type: Reaction
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:

metaM datp c
initial amount: NaN
is: C00131
initial concentration: 1.0
name: dATP
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
is: CHEBI:61404
is: HMDB01532
type: Species
is: SBO:0000247
boundary condition: false

metaR S23T3g
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
kinetic law: MODEL1310110046#
type: Reaction
fast: false
product: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.6
reactant: MODEL1310110046#

metaR DITPtn
name: dITP nuclear transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: true
is: SBO:0000185
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false

metaM 2octpencoa m
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
type: Species
boundary condition: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
constant: false
name: 2,6,9,12,15-octadecapentenoylcoa

metaR SLDt
reversible: false
type: Reaction
name: L-sulfolactate transport (cytosol to extracellular)
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110046#_812a2269_99b3_479a_bec6_ae1ba28189d8
boundary condition: true
constant: false
type: Species
is: P36269
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2687
has only substance units: false
is: SBO:0000252
name: GGT5

metaR PGI
product: MODEL1310110046#
is described by: ECO:0000134
reactant: MODEL1310110046#
fast: false
name: glucose-6-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.9
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:

metaR ST8SIA51g
modifier: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reactant: MODEL1310110046#
reversible: false
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110046#

metaR FAOXC81C61x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaR PAPStg
kinetic law: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110046#
name: 3'-Phosphoadenylyl sufate Golgi transport
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
product: MODEL1310110046#
fast: false
reversible: true
reactant: MODEL1310110046#
type: Reaction

metaR NH4tn
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
name: ammonia nuclear transport
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_e8488829_cda5_4cc7_9c6e_afebf832ca43
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: D6RDW3
is encoded by: hsa:2982
type: Species
name: GUCY1A3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_66ab07b5_5c7a_4a8a_aa98_bd7c05436207
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:91373
is: SBO:0000252
constant: false
has only substance units: false
is: Q3KQV9
name: UAP1L1
boundary condition: true

metaM homoval m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
name: Homovanillate
initial amount: NaN
is: CHEBI:545959
has only substance units: false
type: Species
is: HMDB00118

metaM m4masn g
has only substance units: false
constant: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
boundary condition: false
is: C05881
initial amount: NaN
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR 3AIBt
reversible: false
kinetic law: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
fast: false
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
name: 3-amino-isobutyrate transport

metaM leu L c
has only substance units: false
is: HMDB00687
is: CHEBI:15603
boundary condition: false
constant: false
type: Species
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_f621c6cf_d330_4eec_b8c8_127537e08e2e
is: P48200
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3658
type: Species
initial concentration: NaN
name: IREB2
has only substance units: false
constant: false
initial amount: NaN

metaM ksii core2 deg3 l
constant: false
is: CHEBI:12936
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: HMDB00143
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 3
initial amount: NaN
initial concentration: 1.0

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: SBO:0000247
constant: false
name: Ferricytochrome c
initial concentration: 1.0
is: CHEBI:15991
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

metaM biocyt m
initial concentration: 1.0
boundary condition: false
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
type: Species
name: Biocytin
constant: false
is: SBO:0000247
is: C05552
initial amount: NaN

metaR r2361
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110046#
type: Reaction
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185

metaM ksii core4 pre2 g
is: CHEBI:58053
is: C00130
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C47H76N4O33X CHARGE: -1
type: Species
name: keratan sulfate II boisynthesis, precursor 2
boundary condition: false
is: HMDB00175
has only substance units: false
constant: false

metaM retinal cis 9 c
name: all-trans-retinal
constant: false
is: CHEBI:17898
boundary condition: false
initial concentration: 1.0
is: HMDB01358
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
type: Species
is: SBO:0000247

metaR FAOXC226205m
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is described by: ECO:0000000

metaR RE3218C
name: RE3218
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.1.6.2

http://identifiers.org/biomodels.db/MODEL1310110046#_c6cfceac_123f_4aa5_bc8c_e3f6ca490c8a
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:55229
initial concentration: NaN
is: SBO:0000252
is: Q9NVE7
name: PANK4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_4355316f_0cae_4f29_ab40_dd7dae74ac39
initial concentration: NaN
constant: false
is encoded by: hsa:6582
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC22A2
type: Species

metaR FACOAL241
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110046#
type: Reaction
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
name: fatty-acid--CoA ligase
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true

metaM dtmp m
name: dTMP
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
type: Species
is: HMDB01227
has only substance units: false
constant: false
is: C00364
boundary condition: false

metaM pep c
initial concentration: 1.0
name: Phosphoenolpyruvate
has only substance units: false
type: Species
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: SBO:0000247
boundary condition: false
is: CHEBI:18021
constant: false
is: HMDB00263
initial amount: NaN
is: C00074

http://identifiers.org/biomodels.db/MODEL1310110046#_c2bba37f_856b_4b8b_a255_429ec3875d69
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29906
is: O15466
initial concentration: NaN
type: Species
constant: false
name: ST8SIA5
boundary condition: true
has only substance units: false

metaR HDCACBP
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaR r2360
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_0b7a5d82_356a_4938_ab03_289d6478f9f1
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PSAT1
boundary condition: true
is: Q9Y617
constant: false
type: Species
is encoded by: hsa:29968
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_278a93d6_9a26_4ada_9d4e_f774dbe699e1
type: Species
initial concentration: NaN
boundary condition: true
name: SLC25A6
is encoded by: hsa:293
is: Q6I9V5
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM elaidcrn c
type: Species
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB06464
name: Elaidic carnitine
initial amount: NaN

metaR FACOAL240
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110046#_07a86ddb_e325_4882_9534_3d4477bace23
boundary condition: true
is encoded by: hsa:1215
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: CMA1
is: Q4FEB3
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_c69a126a_5c14_4a57_9ea3_3cf971aba60a
has only substance units: false
is encoded by: hsa:5281
initial amount: NaN
is encoded by: hsa:84720
boundary condition: true
name: PIGF:PIGO
has part: Q8TEQ8
has part: Q07326
type: Species
constant: false
initial concentration: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110046#_0a8d250c_68d5_46cb_972a_ad47f0f165c2
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: MAOA
is encoded by: hsa:4128
is: Q53YE7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_5ceebcb0_b2f6_401e_a3ea_99693752095c
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: Q16853
name: AOC3
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8639

http://identifiers.org/biomodels.db/MODEL1310110046#_c10fe3e8_efce_41f9_83a9_0f3f8a428a67
has only substance units: false
boundary condition: true
initial amount: NaN
name: ATP5G3
is: P48201
initial concentration: NaN
type: Species
is encoded by: hsa:518
constant: false
is: SBO:0000252

metaR r0739
is described by: ECO:0000000
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1

metaR CYTDt
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
name: cytidine facilated transport in cytosol
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185

metaM 3dpdhb m
is: CHEBI:50775
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
initial concentration: 1.0

metaR LEUKTRF4t
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
fast: false
type: Reaction
name: leukotriene F4 transport
product: MODEL1310110046#

metaM itp c
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
constant: false
is: CHEBI:57614
is: HMDB00189
initial amount: NaN
has only substance units: false
boundary condition: false
name: ITP(3-)
initial concentration: 1.0
type: Species

metaM hs deg14 l
name: heparan sulfate, degradation product 14
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
type: Species
is: CHEBI:16126
initial amount: NaN

metaR ARACHDt2
kinetic law: MODEL1310110046#
name: fatty acid transport via diffusion
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM c6dc x
has only substance units: false
name: adipoyl carnitine
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: HMDB04047
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247
is: C14143

metaM dutp c
is: C00460
is: CHEBI:17625
name: dUTP
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01191
initial amount: NaN
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
type: Species

metaM tcynt m
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
is: CHEBI:18022
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM ocdececrn m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 11-octadecenoyl carnitine
constant: false
boundary condition: false
is: HMDB06351
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
type: Species

metaR UDPtl
type: Reaction
is: SBO:0000185
reactant: MODEL1310110046#
fast: false
reversible: true
name: udp intracellular transport
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ

metaM leuktrB4 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
is: CHEBI:57461
has only substance units: false
type: Species
name: leukotriene B4(1-)
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01085

metaR XOL7AH2tm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
name: lipid, flip-flop intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_aadeb00b_c9c2_4b0e_937b_ba7ad60b8c9c
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AA177072_1_c
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:AA177072

http://identifiers.org/biomodels.db/MODEL1310110046#_582a5c46_9d5c_4dc1_b039_0bd2c81b7e5f
is: P49888
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SULT1E1
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:6783

metaM ump r
is: HMDB00288
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
boundary condition: false
has only substance units: false
name: UMP
initial concentration: 1.0
is: CHEBI:57865
type: Species
is: SBO:0000247

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaM 2docopencoa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
constant: false
name: 2,7,10,13,16-docosapentenoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_984d5b1f_67cb_4e0d_8b0f_95bc7c234277
initial concentration: NaN
is encoded by: hsa:7498
is: P47989
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: XDH
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_96402a39_ac00_41cf_8b32_46af1ffb2367
boundary condition: true
has only substance units: false
is: Q86SR1
initial concentration: NaN
is encoded by: hsa:55568
initial amount: NaN
is: SBO:0000252
type: Species
name: GALNT10
constant: false

metaR 3SALATAim
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
reactant: MODEL1310110046#
is described by: ECO:0000304
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110046#

metaR MI3PP
name: myo-inositol 3-phosphatase
type: Reaction
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.3.25
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
reversible: false
product: MODEL1310110046#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaM dgtp c
initial concentration: 1.0
type: Species
name: dGTP
is: HMDB01440
initial amount: NaN
has only substance units: false
is: CHEBI:16497
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
constant: false
is: C00286

http://identifiers.org/biomodels.db/MODEL1310110046#_c371e392_73e5_412e_adc4_45c22f2c8666
is: SBO:0000252
initial concentration: NaN
name: CA14
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:23632
is: A8K3J4
constant: false

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR DCSPTN1CRNt
kinetic law: MODEL1310110046#
is: SBO:0000185
product: MODEL1310110046#
type: Reaction
name: transport into the mitochondria (carnitine)
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110046#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110046#

metaR DUDPtn
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110046#
name: dUDP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110046#_ef4b7628_6d76_4be7_a7e1_3e1e78778385
name: CYP1B1
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:1545
type: Species
is: Q16678
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM lgnccoa x
is: SBO:0000247
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
initial amount: NaN
constant: false
is: HMDB06526
name: lignocericyl coenzyme A
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_32f6600b_5895_4fdf_bd27_53ed2025bdf1
constant: false
initial amount: NaN
has only substance units: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:509
is: SBO:0000297
initial concentration: NaN
type: Species
is encoded by: hsa:498
boundary condition: true
has part: P25705
has part: Q6I9V2

metaR DADNt4
is: SBO:0000185
type: Reaction
name: deoxyadenosine transport via diffusion
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true

metaR GLNSERNaEx
is described by: ECO:0000269
modifier: MODEL1310110046#
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110046#
type: Reaction
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110046#
is: SBO:0000185

metaR ELAIDt
reversible: true
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110046#
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110046#

metaR CYSTHRNaEx
product: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110046#
is: SBO:0000185
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110046#

metaM hs deg2 l
initial concentration: 1.0
has only substance units: false
is: HMDB01352
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17180
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
boundary condition: false
name: heparan sulfate, degradation product 2
type: Species

metaM leuktrB4 e
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461
is: SBO:0000247
type: Species
constant: false
has only substance units: false
boundary condition: false
name: leukotriene B4(1-)
initial concentration: 1.0
is: HMDB01085

metaM acgal c
constant: false
is: HMDB00212
type: Species
is: SBO:0000247
is: CHEBI:28037
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: N-acetyl-D-galactosamine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_9c3cde1d_8c9c_4a9f_87b0_38dad16700cd
initial concentration: NaN
is: P26572
initial amount: NaN
type: Species
constant: false
name: MGAT1
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:4245

metaR LEUTA
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000269
reversible: true
name: leucine transaminase
fast: false
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42

metaR DMNONCRNt
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
fast: false
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)

metaM cs b deg3 l
type: Species
has only substance units: false
constant: false
is: CHEBI:21338
initial amount: NaN
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: HMDB02704

metaR UPPN
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
fast: false
modifier: MODEL1310110046#
name: b-ureidopropionase
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110046#
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_ece0fa76_d7e1_4d1e_b668_026ee2a32232
type: Species
is: E7EPT3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:501
constant: false
name: ALDH7A1

metaR FRDPtc
reactant: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
name: lipid, flip-flop intracellular transport
fast: false
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_ae95d949_b103_40f5_bde0_0ad17e9d690a
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AI291895_1_c
initial concentration: NaN
is encoded by: hsa:AI291895

metaM 2dodtricoa m
has only substance units: false
name: 2,6,9-dodecatrienoylcoa
constant: false
type: Species
is: SBO:0000247
is: HMDB11123
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial amount: NaN
is: C05279
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_109bea78_3509_445d_95c7_3f22728051bc
has only substance units: false
initial concentration: NaN
name: CYP8B1
is: Q9UNU6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1582
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_f3f2dabd_f2a5_404b_abcc_80bbf0755ca3
initial amount: NaN
is encoded by: hsa:3030
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
name: HADHA
is: E9KL44

metaM 6pgl r
is: CHEBI:57955
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: HMDB01127

http://identifiers.org/biomodels.db/MODEL1310110046#_73687db8_ca52_433f_a09d_a5672903db84
is: B4DR31
has only substance units: false
initial amount: NaN
is encoded by: hsa:1808
name: DPYSL2
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r0733
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reversible: false
modifier: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
fast: false

metaM bildglcur c
initial concentration: 1.0
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58471
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
has only substance units: false

metaR r1090
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
reversible: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2

metaM pmtcoa c
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01338
initial amount: NaN
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
boundary condition: false
type: Species

metaR FAOXC61m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR NDPK9n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110046#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110046#
is described by: ECO:0000269

metaR r0464
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110046#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:

metaR FAOXC18280m
reversible: false
fast: false
name: Beta oxidation of fatty acid
modifier: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaR UGT1A10r
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.17
fast: false
type: Reaction
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal

metaM ksi deg25 l
initial amount: NaN
is: CHEBI:16953
initial concentration: 1.0
name: keratan sulfate I, degradation product 25
has only substance units: false
type: Species
is: HMDB00812
boundary condition: false
is: SBO:0000247
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
constant: false

metaR CERT2gt
product: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: ceramide transport protein
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
fast: false

metaR DADA
fast: false
name: Deoxyadenosine deaminase
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.4
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false

metaM coa e
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
initial concentration: 1.0
name: Coenzyme A
type: Species
boundary condition: false
constant: false
is: C00010
has only substance units: false
is: CHEBI:57287
is: HMDB01423

metaM 2ddecdicoa m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
is: C05279
initial amount: NaN
constant: false
type: Species
is: HMDB11123
is: SBO:0000247
name: 2,6-dodecadienoylcoa

metaR r0732
fast: false
type: Reaction
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_5dbbdfe8_aa5e_4bf0_9efe_109782004d81
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:43
initial concentration: NaN
boundary condition: true
name: ACHE
initial amount: NaN

metaR PYAM5POr
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is described by: ECO:0000269
name: pyridoxamine 5'-phosphate oxidase
reversible: true

metaM CE4876 r
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
name: delta12-Prostaglandin J2
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR r0463
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
is described by: ECO:0000000
type: Reaction
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
is: SBO:0000176
reversible: true
fast: false

metaR S2TASE2ly
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110046#
name: iduronate-2-sulfatase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#

metaR EHGLATm
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: false
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
fast: false
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000212
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#

metaR COQ6m
modifier: MODEL1310110046#
name: Ubiquinone biosynthesis monooxgenase COQ6
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
fast: false
type: Reaction
product: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: false
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110046#_31c9b7be_bd57_4e0d_9345_e2a8844b20ef
has only substance units: false
boundary condition: true
constant: false
type: Species
name: FAH
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2184
is: P16930

metaR r1809
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110046#

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaM itp e
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
is: CHEBI:57614
is: HMDB00189
type: Species
name: ITP(3-)
has only substance units: false
boundary condition: false

metaR r0731
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR FAOXC101x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR r1954
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_696a3842_a865_42da_a993_534032dbf51d
has only substance units: false
name: BTD
is encoded by: hsa:686
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: P43251
type: Species
initial amount: NaN

metaR BTNt4i
kinetic law: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
fast: false
product: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
is: SBO:0000185
name: Biotin uptake (antiport)
type: Reaction
reactant: MODEL1310110046#

metaR PAIL4P HStn
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
is: SBO:0000185
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaM dopasf c
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:37946
name: dopamine 3-O-sulfate
is: HMDB06275
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_5c8d3115_c672_48b4_84df_93a5d64e9484
initial amount: NaN
boundary condition: true
name: OGDHL
is: SBO:0000252
is encoded by: hsa:55753
constant: false
type: Species
is: Q9ULD0
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_1a31ff5c_768a_4a26_ba12_5ecdff188963
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10965
name: ACOT2
boundary condition: true
initial concentration: NaN
type: Species
is: P49753
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_2ec28964_68b7_46fb_a64f_2cd36be36622
is: B1AM93
initial concentration: NaN
is encoded by: hsa:4702
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: NDUFA8

metaR r1955
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM coa c
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: HMDB01423
initial amount: NaN
name: Coenzyme A
initial concentration: 1.0
is: CHEBI:3312
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: C00010
constant: false

metaR ACACt2m
kinetic law: MODEL1310110046#
name: Acetoacetate mitochondrial transport via H+ symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185

metaR FUCtly
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
fast: false
name: L-fucose efflux from lysosome
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
type: Reaction

metaR r0730
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
modifier: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR RE3270C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110046#
name: RE3270
reversible: true

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR GAMt1r
is: SBO:0000185
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
reactant: MODEL1310110046#
reversible: true
product: MODEL1310110046#
fast: false
type: Reaction
name: glucosamine transport (uniport)
is described by: ECO:0000269
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_919c2647_4807_4b59_8597_7ab6a87d7bbf
name: NT5E
is: SBO:0000252
is encoded by: hsa:4907
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: P21589
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_08f5f273_6d77_4935_8b86_53ab76d5380f
initial concentration: NaN
boundary condition: true
is: SBO:0000297
type: Species
name: ATP1A3:ATP1B1
has part: B7Z2T0
initial amount: NaN
is encoded by: hsa:478
has only substance units: false
constant: false
has part: A3KLL5
is encoded by: hsa:481

metaM dopasf e
boundary condition: false
is: CHEBI:37946
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: dopamine 3-O-sulfate
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: SBO:0000247
is: HMDB06275
type: Species

metaR GPIDA2er
is: SBO:0000176
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_9d67b014_394c_41c0_ba2a_8eea8217b326
boundary condition: true
is encoded by: hsa:8501
constant: false
name: SLC43A1
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: O75387

metaM HC02206 e
is: CHEBI:57399
type: Species
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
has only substance units: false
is: SBO:0000247
name: prostaglandin C1(1-)
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_ca0b304e_ad2c_40cd_af58_169fad281655
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:57835
boundary condition: true
name: SLC4A5
initial concentration: NaN
is: Q9BY07
initial amount: NaN

metaR FRUt4
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
fast: false
name: D-fructose transport via sodium cotransport
is described by: ECO:0000269
product: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction

metaR r0842
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
modifier: MODEL1310110046#
is: SBO:0000185
reversible: true

metaR ALDD2xm
is: SBO:0000176
reversible: false
product: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
kinetic law: MODEL1310110046#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110046#_d961eea9_ec04_4d62_b412_c2ac71e89235
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
type: Species
name: SLC7A11:SLC3A2
is encoded by: hsa:23657
has part: Q9UPY5
constant: false

metaM oagt3 hs e
has only substance units: false
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
is: SBO:0000247
is: HMDB02168
boundary condition: false
initial amount: NaN
constant: false
name: 9-O-Acetylated GT3
is: CHEBI:18421
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_166ded48_bdab_455a_80a8_2e15ba1dc9ab
is encoded by: hsa:509
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: ATP5C1
has only substance units: false
initial concentration: NaN
constant: false
is: P36542

http://identifiers.org/biomodels.db/MODEL1310110046#_0d858967_8bac_4a9a_90fb_b7eb99615303
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:AL038231
initial amount: NaN
initial concentration: NaN
constant: false
name: _AL038231_1_c

http://identifiers.org/biomodels.db/MODEL1310110046#_3048ed3b_7dd6_42f3_a8d2_0546db3c3bac
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:23533
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: PIK3R5
is: Q8WYR1

metaM dhcholoylcoa x
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
type: Species
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: HMDB06895
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:27393
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM hs deg5 l
has only substance units: false
constant: false
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: CHEBI:17895
is: SBO:0000247
boundary condition: false
is: HMDB00158
initial concentration: 1.0
initial amount: NaN
type: Species
name: heparan sulfate, degradation product 5

metaR PRFGS
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.3.5.3
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
fast: false
name: phosphoribosylformylglycinamidine synthase
reversible: false

metaR PE HStm
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
reversible: true

metaR MI34PP
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.66
reactant: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
name: inositol-3,4-bisphosphate 4-phosphatase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5d940d4d_48dc_458d_a242_5076b1c448be
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6534
initial amount: NaN
name: SLC6A7
boundary condition: true
is: Q99884
constant: false
initial concentration: NaN
type: Species

metaR DHCR71r
name: 7-dehydrocholesterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.21
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
fast: false
reversible: false
modifier: MODEL1310110046#
type: Reaction
is described by: ECO:0000134

metaM doco13ac e
initial amount: NaN
is: HMDB02068
initial concentration: 1.0
name: docosenoic acid (C22:1)
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C22H41O2 CHARGE: -1
has only substance units: false
boundary condition: false

metaM mercppyr c
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 3-mercaptopyruvate
is: HMDB01368
is: CHEBI:57678
is: SBO:0000247
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
constant: false
type: Species

metaM ksi deg38 l
name: keratan sulfate I, degradation product 38
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false

metaR PI345P3P
is version of: http://identifiers.org/ec-code/3.1.3.67
reactant: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD

metaR r0575
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.48
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
type: Reaction

metaM 2octdectecoa m
type: Species
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
name: 2,6,9,12-octadecatetraenoylcoa
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_79a03944_6ea5_4a4a_8acc_ca8d9c88891d
has only substance units: false
constant: false
is: P48728
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:275
name: AMT
initial amount: NaN
is: SBO:0000252

metaR r0840
kinetic law: MODEL1310110046#
is: SBO:0000185
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.13.70
type: Reaction
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reversible: true
fast: false
product: MODEL1310110046#
is described by: ECO:0000000
name: Free diffusion

metaM crtsl r
is: CHEBI:17650
is: HMDB00063
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: cortisol
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
type: Species

metaM HC01231 m
type: Species
is: CHEBI:58480
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false
boundary condition: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM bildglcur e
is: SBO:0000247
boundary condition: false
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
constant: false
initial amount: NaN
has only substance units: false

metaM oagt3 hs g
initial concentration: 1.0
initial amount: NaN
type: Species
name: 9-O-Acetylated GT3
is: HMDB01514
is: SBO:0000247
is: C00329
has only substance units: false
is: CHEBI:17315
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
boundary condition: false
constant: false

metaR PEROXx
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
reactant: MODEL1310110046#
name: peroxisomal lumped long chain fatty acid oxidation
is: SBO:0000176
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_21eeebe3_fdb7_43f3_b89f_d3b5d4083460
initial amount: NaN
name: NDUFA13
boundary condition: true
initial concentration: NaN
type: Species
is: Q9P0J0
constant: false
is encoded by: hsa:51079
has only substance units: false
is: SBO:0000252

metaR GALASE8ly
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110046#
fast: false

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM memgacpail hs r
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:15809
constant: false

metaR C6DCc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_84684d2e_a21a_4a63_a8ee_ad0cc067a2ae
name: GUCY1B2
initial amount: NaN
constant: false
is encoded by: hsa:2974
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_9f717a30_8347_4eb0_a6b3_47b5e7e4c798
has only substance units: false
constant: false
name: PDE3A
type: Species
initial amount: NaN
initial concentration: NaN
is: Q14432
is: SBO:0000252
is encoded by: hsa:5139
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_771d6034_3720_405d_ab06_5fb55ae85bbe
is: P14324
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: FDPS
initial amount: NaN
is encoded by: hsa:2224
initial concentration: NaN
type: Species

metaR r1682
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false
product: MODEL1310110046#

metaM 2ddecdicoa x
initial amount: NaN
is: HMDB11123
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
type: Species
name: 2,6-dodecadienoylcoa
is: SBO:0000247
has only substance units: false
is: C05279
boundary condition: false

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR MDH
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110046#
is described by: ECO:0000134
reactant: MODEL1310110046#
reversible: true
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:Biochemical
name: malate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.37
product: MODEL1310110046#

metaR ACP1 FMN
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
product: MODEL1310110046#
name: acid phosphatase (FMN)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction

metaR FAOXC5C3x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_57b562d7_6665_4d3f_8d4b_c7d4138650f2
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: CYP1A2
is encoded by: hsa:1544
is: P05177

metaM ksi pre16 g
boundary condition: false
is: SBO:0000247
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 16
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
is: C00130
constant: false
type: Species
initial amount: NaN
is: HMDB00175

metaR r1806
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110046#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_8857de21_2dae_4dbe_b23c_b6f5b96f0e63
name: VNN1
initial amount: NaN
is encoded by: hsa:8876
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: O95497
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_166f5586_afe8_436b_b350_25813fc435d4
initial concentration: NaN
is: B2RDU6
constant: false
is encoded by: hsa:4598
boundary condition: true
initial amount: NaN
type: Species
name: MVK
is: SBO:0000252
has only substance units: false

metaR PPAm
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000269
product: MODEL1310110046#
name: inorganic diphosphatase
modifier: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1

http://identifiers.org/biomodels.db/MODEL1310110046#_93c2eba7_7f68_4b16_b8c8_d3a54aac167b
name: PLCL1
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5334
type: Species
is: SBO:0000252
is: Q15111

http://identifiers.org/biomodels.db/MODEL1310110046#_8363eea0_8e5e_4354_8450_d485714a1d6b
is encoded by: hsa:80724
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: ACAD10
is: G3XAJ0
has only substance units: false

metaM ump n
is: CHEBI:57865
type: Species
initial amount: NaN
initial concentration: 1.0
name: UMP(2-)
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM octd11ecoa c
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280771
name: 11-octadecenoylcoa
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_3412b224_dc6a_4dfb_b803_aa1419f19bcb
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:51727
is: B2R6S5
name: CMPK1
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_5da58a6c_f2e4_4c52_9ff5_d8171c1e2a1d
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:316
name: AOX1
is: SBO:0000252
boundary condition: true
is: Q06278
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_9f897eec_3efc_45b5_a7be_0da3277e7c5c
is encoded by: hsa:10993
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P20132
is: SBO:0000252
name: SDS
constant: false
type: Species

metaR ABUTt2r
fast: false
is: SBO:0000185
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: 4-aminobutyrate reversible transport in via proton symport
product: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r

metaR SACCD4m
type: Reaction
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
is: SBO:0000176
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.1.8
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false

metaR DM anth
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR TCHOLAte
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
product: MODEL1310110046#
name: bile acid intracellular transport
fast: false
reversible: true
is: SBO:0000185

metaM na1 c
notes: FORMULA: Na CHARGE: 1
initial concentration: 1.0
boundary condition: false
is: C01330
is: SBO:0000247
is: HMDB00588
type: Species
name: Sodium
constant: false
is: CHEBI:4541
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_7705a668_779e_465b_b5bf_dadddebf895b
is encoded by: hsa:2348
initial concentration: NaN
name: FOLR1
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaR CYSTA
name: cysteine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
modifier: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000304
is: SBO:0000176
reversible: true

metaM ump m
name: UMP(2-)
constant: false
is: HMDB00288
is: SBO:0000247
is: CHEBI:57865
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
initial concentration: 1.0

metaM pristanal x
type: Species
boundary condition: false
name: pristanal
is: SBO:0000247
is: HMDB01958
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
constant: false
initial concentration: 1.0
is: CHEBI:49189
has only substance units: false
initial amount: NaN

metaR LNLNCACPT1
product: MODEL1310110046#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110046#
name: carnitine O-palmitoyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110046#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9ebd58b8_f6ab_48b4_a6e5_e0d0efd087e4
is encoded by: hsa:54677
has only substance units: false
constant: false
boundary condition: true
is: E7EQF2
initial amount: NaN
type: Species
name: CROT
initial concentration: NaN
is: SBO:0000252

metaR P5CDm
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000269
modifier: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
fast: false
product: MODEL1310110046#
reactant: MODEL1310110046#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_ead114e6_b2d6_4a28_ac1c_e0fd1d970190
has only substance units: false
name: PKM2
boundary condition: true
is: P14618
initial concentration: NaN
is encoded by: hsa:5315
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM CE2431 m
name: cis-deca-4-enoyl-CoA
constant: false
is: CHEBI:57795
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_6e769f8d_831d_4e06_8abe_c3daa967ae7d
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q969I6
is encoded by: hsa:55089
name: SLC38A4

metaM 2oxoadp m
is: HMDB00225
has only substance units: false
is: CHEBI:57499
constant: false
boundary condition: false
name: 2-oxoadipate(2-)
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial amount: NaN

metaM sbcoa x
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
has only substance units: false
initial concentration: 1.0
name: suberylcoa

metaM malt e
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: C00208
has only substance units: false
is: HMDB00163
is: CHEBI:17306
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
initial concentration: 1.0
name: Maltose

metaR LTD4DP
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reversible: true
name: Leukotriene D4 dipeptidase
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000176

metaR r1800
name: Y+LAT2 Utilized transport
modifier: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR C161CPT12
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110046#
name: carnitine O-palmitoyltransferase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000269
type: Reaction
reversible: false
modifier: MODEL1310110046#

metaR TYMSFt
is: SBO:0000185
name: Tyramine O-sulfate transport (diffusion)
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate

http://identifiers.org/biomodels.db/MODEL1310110046#_f5798500_89b7_4ffe_8fcd_e1b1f2712a71
name: SLC24A4
is: SBO:0000252
type: Species
is: Q8NFF2
has only substance units: false
boundary condition: true
is encoded by: hsa:123041
initial amount: NaN
initial concentration: NaN
constant: false

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110046#_6fdcd70b_5f52_4a77_84b9_92bb8fa3cbfd
has only substance units: false
initial concentration: NaN
is: P56181
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: NDUFV3
is encoded by: hsa:4731
initial amount: NaN

metaM HC02206 c
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
name: prostaglandin C1(1-)
constant: false
initial concentration: 1.0
is: CHEBI:57399
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110046#_18183243_ab45_493a_84b9_fdf5ada38a8f
initial concentration: NaN
is encoded by: hsa:27034
is: Q6ZWP6
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: ACAD8

http://identifiers.org/biomodels.db/MODEL1310110046#_2e00a776_45a7_452e_8694_f7517ffb6eea
initial concentration: NaN
is encoded by: hsa:2271
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: P07954
has only substance units: false
name: FH
is: SBO:0000252

metaR RE2998M
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
name: RE2998
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#

metaR APRGSTRNte
is: SBO:0000185
reversible: true
reactant: MODEL1310110046#
name: hydroxyprogesterone transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#

metaM itp n
name: ITP(3-)
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57614
is: HMDB00189

metaM na1 e
constant: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00588
name: Sodium
boundary condition: false
is: C01330
is: CHEBI:4541
type: Species

metaR r0579
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.13.11.19
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_1293bfb1_f5bb_4f24_a73f_76d8cbd4cf11
is: B2RDZ2
constant: false
type: Species
name: RFK
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55312
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110046#_6a53f272_cbaf_4182_ae0f_1acfa09d4f85
is: P50225
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SULT1A1
boundary condition: true
is encoded by: hsa:6817

http://identifiers.org/biomodels.db/MODEL1310110046#_4248fad6_0d36_4352_8e73_4e18fd82d66a
is: Q549M5
constant: false
name: NDUFC2
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4718

metaR r1801
type: Reaction
fast: false
product: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110046#_3f63ea35_0b95_4893_8e18_314b3efd9340
type: Species
is: O43678
is: SBO:0000252
name: NDUFA2
initial concentration: NaN
constant: false
is encoded by: hsa:4695
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_65a72b6a_9a9a_41b3_879a_a6dce70e253d
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: CLC
is encoded by: hsa:1178
initial amount: NaN
is: C5HZ13
initial concentration: NaN

metaM ksi deg22 l
is: CHEBI:16953
has only substance units: false
is: HMDB00812
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
initial concentration: 1.0
name: keratan sulfate I, degradation product 22
boundary condition: false
type: Species

metaM tetde5coa x
has only substance units: false
is: HMDB13109
is: SBO:0000247
name: 5-tetradecenoylcoa
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4

metaR BACCLm
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110046#
fast: false
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
reversible: false
is: SBO:0000176
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000254

metaM lneldccoa c
is: http://identifiers.org/pubchem.compound/9543677
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB06521
constant: false
name: linoelaidyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110046#_64688ac4_ddda_497a_9e3b_84c8206d4de7
name: AQP8
is: O94778
constant: false
boundary condition: true
is encoded by: hsa:343
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_3cb2485e_14cc_4833_a687_9fe6515c1e2d
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: P16499
is encoded by: hsa:5145
boundary condition: true
name: PDE6A

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR DHORTS
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
fast: false
name: dihydroorotase
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.1.3.2
reactant: MODEL1310110046#
is described by: ECO:0000269

metaM glyald m
is: CHEBI:17378
initial amount: NaN
boundary condition: false
name: D-glyceraldehyde
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaR r0578
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110046#
type: Reaction
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true

metaM dgtp e
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:16497
name: dGTP

metaR PEt
type: Reaction
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000185
name: phosphatidylethanolamine transport
fast: false
reversible: true
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_3d2f33d2_37b8_4a89_95a8_2eb51b003973
boundary condition: true
is: Q02338
has only substance units: false
initial concentration: NaN
is encoded by: hsa:622
name: BDH1
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_e5f67779_c5c7_4a7e_b732_fe61f36db5ca
name: SLC4A3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: P48751
is encoded by: hsa:6508

http://identifiers.org/biomodels.db/MODEL1310110046#_669050e9_2a83_4159_9af8_6ce020b1a812
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: ENTPD1
constant: false
is: Q86VV3
is encoded by: hsa:953
is: SBO:0000252
initial amount: NaN

metaR S3TASE2ly
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110046#
name: N-acetylglucosamine-3-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110046#_c0ab4232_939b_4d96_90d0_a28e60a2581b
initial concentration: NaN
is encoded by: hsa:1607
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: DGKB
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_c8416791_6f5e_42f1_8b02_9d22468129ff
name: _AA614647_1_c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA614647
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM hestratriol c
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
has only substance units: false
is: HMDB05896
name: 4,17 dihydroxy estradiol

metaM cysam c
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: cysteaminium
is: HMDB02991
is: CHEBI:58029
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
constant: false
initial concentration: 1.0
has only substance units: false

metaR r0835
fast: false
modifier: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaM HC01115 c
boundary condition: false
name: NeuNGc
constant: false
type: Species
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: CHEBI:29025
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_f848b08c_739d_4129_8798_25ea826a4751
boundary condition: true
name: SLC25A26
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:115286

metaM ksi pre36 g
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 36
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
is: SBO:0000247

metaR S6T15g
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reversible: false
type: Reaction
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_323f91e0_50f0_43c6_8a97_bb3cb79cd549
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PIP5K1C
is encoded by: hsa:23396
is: O60331
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_0a7ece10_efd6_4dbf_97e8_645321703519
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PIGP
is encoded by: hsa:51227

http://identifiers.org/biomodels.db/MODEL1310110046#_14040a45_c2b6_45e7_be77_dbcd3bf13d05
has only substance units: false
is: SBO:0000252
is: P08397
name: HMBS
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:3145
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_9ab8f18a_813c_493b_937d_faa9ecf07f72
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: G5E960
name: PLCB3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5331

metaR FAOXC204
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110046#
product: MODEL1310110046#
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_36954cec_ec61_4f9d_9cae_50876728775e
is encoded by: hsa:285973
name: ATG9B
boundary condition: true
initial amount: NaN
type: Species
is: Q674R7
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_dc88af47_c3f3_4877_96db_171662681303
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:AI601100
initial amount: NaN
has only substance units: false
name: _AI601100_1_m

http://identifiers.org/biomodels.db/MODEL1310110046#_0823e707_0f91_47ec_826a_d81fd0b70a91
boundary condition: true
type: Species
initial concentration: NaN
name: ST3GAL3
is encoded by: hsa:6487
constant: false
has only substance units: false
initial amount: NaN
is: Q96L53
is: SBO:0000252

metaR PRGSTRNt
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110046#
name: Progesterone transport
reversible: true
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000185
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_e30aeaba_1f2d_4e8d_a4ad_6cfbf8dea658
is encoded by: hsa:645
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: BLVRB
is: P30043
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_8ce9a056_2b04_410c_a95e_9a8ec2120096
type: Species
is: E9PB82
boundary condition: true
initial amount: NaN
constant: false
name: HSD17B4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3295

metaM arachcoa c
name: arachidyl coenzyme A
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:15527
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
is: HMDB04258

metaR GPIAT
product: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
reversible: false
modifier: MODEL1310110046#
type: Reaction
name: glucosaminylphosphatidyl inositol acetyltransferase
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD

metaR FAOXC61x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR C3STKR2r
fast: false
product: MODEL1310110046#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
kinetic law: MODEL1310110046#
name: C-3 sterol keto reductase (zymosterol)
reversible: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
modifier: MODEL1310110046#

metaR LALDO2x
modifier: MODEL1310110046#
type: Reaction
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaM 3dsphgn c
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58299
initial amount: NaN
is: HMDB01480
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium

metaR r1088
name: Active transport
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#

metaM C04849 e
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: SBO:0000247
initial amount: NaN
is: CHEBI:57449
has only substance units: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
initial concentration: 1.0
constant: false

metaM cyan m
is: CHEBI:18407
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02084
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
name: hydrogen cyanide
boundary condition: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM hestratriol e
is: SBO:0000247
name: 4,17 dihydroxy estradiol
boundary condition: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB05896
initial concentration: 1.0

metaR r2359
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110046#

metaM dc2coa x
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01168
name: trans-Dec-2-enoyl-CoA
type: Species
initial concentration: 1.0
has only substance units: false

metaM oxa c
name: oxalate(2-)
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: HMDB02329
is: CHEBI:30623
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false

metaM ile L m
boundary condition: false
is: HMDB00172
name: L-isoleucine
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:17191
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaM CE5786 e
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:27485
is: SBO:0000247
initial amount: NaN
is: HMDB02710
name: kinetensin
initial concentration: 1.0
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
type: Species

metaR 3SALAOX
name: cysteinesulfinic acid oxidase
product: MODEL1310110046#
fast: false
reversible: false
reactant: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
is: SBO:0000176

metaR r0838
product: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reversible: true
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: Free diffusion
is: SBO:0000185
modifier: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4

metaR 4ABUTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
is described by: ECO:0000000
name: 4-aminobutanoate mitochondrial transport via diffusion
kinetic law: MODEL1310110046#
fast: false
reversible: true
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000185
product: MODEL1310110046#

metaM ptdca e
name: pentadecanoate
type: Species
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/22169126
boundary condition: false
is: HMDB00826
constant: false
initial amount: NaN

metaR S4TASE1ly
type: Reaction
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.12
is: SBO:0000176
fast: false

metaR RE3628M
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3628
type: Reaction
fast: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true

metaM tetpent3 e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: tetracosapentaenoic acid, n-3
is: HMDB06323
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM hexde7coa x
is: SBO:0000247
name: 7-hexadecenoylcoa
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02288
initial concentration: 1.0

metaM pmtcoa x
boundary condition: false
is: HMDB01338
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false

metaR RE3003M
modifier: MODEL1310110046#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110046#
name: RE3003
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r2358
type: Reaction
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110046#

metaM xol7ah2al m
is: SBO:0000247
type: Species
is: CHEBI:27428
initial concentration: 1.0
is: HMDB06894
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445

metaR AKR1D2
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.3
type: Reaction
reversible: false
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110046#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_661eeb71_de9d_4099_8336_8c67ec2d4215
is: P54819
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:204
name: AK2
boundary condition: true
is: SBO:0000252
type: Species

metaM 3sala m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: CHEBI:61085
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: 3-sulfino-L-alanine (1-)
type: Species
is: C00606

metaR GALASE1ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110046#
fast: false
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
name: beta-galactosidase, lysosomal
is described by: ECO:0000000

metaR LNELDCCRNt
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
reversible: false

metaR r2357
type: Reaction
kinetic law: MODEL1310110046#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaR RE0958E
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
reversible: true
reactant: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110046#
name: RE0958
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR r0570
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
is: SBO:0000176
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is version of: http://identifiers.org/ec-code/6.3.3.2
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX c4crn
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_103619b2_4162_4aa3_82ad_5057a5e7d90b
is: O15269
is encoded by: hsa:10558
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SPTLC1
has only substance units: false
boundary condition: true
type: Species
constant: false

metaM ptdca c
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial amount: NaN
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/22169126
name: pentadecanoate
is: HMDB00826
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

metaM lcts e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17716
has only substance units: false
name: Lactose
is: C00243
boundary condition: false
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
constant: false
is: HMDB00186
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_7e43141d_bd08_4331_a075_5e7da688d749
is: SBO:0000252
is encoded by: hsa:6307
boundary condition: true
has only substance units: false
is: A8MYF6
constant: false
initial concentration: NaN
type: Species
name: MSMO1
initial amount: NaN

metaM ksi pre22 g
type: Species
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 22
initial amount: NaN
is: C00130
is: SBO:0000247
boundary condition: false
is: HMDB00175
notes: FORMULA: C185H297N13O150S6X CHARGE: -7

metaR CKc
product: MODEL1310110046#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.3.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1152.1) or (1158.1) and (1152.1) or (1158.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:2883200,PMID:3034271 NOTES:kegg C02305 MJC SAB c
reactant: MODEL1310110046#
name: ATP Creatine kinase (c)
kinetic law: MODEL1310110046#
is: SBO:0000176
fast: false
modifier: MODEL1310110046#

metaR r2356
kinetic law: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110046#
fast: false
product: MODEL1310110046#
is: SBO:0000185
type: Reaction

metaR DURIt
name: deoxyuridine transport via diffusion
fast: false
type: Reaction
product: MODEL1310110046#
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110046#
is: SBO:0000185

metaR PPCOACm
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
is version of: http://identifiers.org/ec-code/6.4.1.3
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
is: SBO:0000176
name: Propionyl-CoA carboxylase, mitochondrial
modifier: MODEL1310110046#
is described by: ECO:0000269

metaR r0571
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.5.1.8
fast: false
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_83da0659_09fa_4673_9fed_740793fa9fb4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:55350
name: VNN3
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_734c2f07_6183_49c8_b83b_a2a010a189d6
is: Q96H96
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: COQ2
is encoded by: hsa:27235
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaM 2octdectecoa x
boundary condition: false
type: Species
constant: false
name: 2,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355

metaM gluala e
name: 5-L-Glutamyl-L-alanine
initial concentration: 1.0
initial amount: NaN
is: C03740
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: HMDB06248
type: Species
is: http://identifiers.org/pubchem.compound/6503
constant: false

metaM pmtcoa r
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
constant: false
is: HMDB01338
boundary condition: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:3454
has only substance units: false
initial amount: NaN

metaR UMPK2n
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (CTP),nuclear
is: SBO:0000176
modifier: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#

metaR r0119
reactant: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.14
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
modifier: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
reversible: false
is described by: ECO:0000000
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:

metaR XYLtly
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000185
name: Xylose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110046#
type: Reaction
reversible: false

metaM nrvnccoa c
name: nervonyl coenzyme A
constant: false
type: Species
is: C16532
initial amount: NaN
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_b1b8cf6e_8f4f_4571_98d8_1536f8501863
name: PHPT1
is encoded by: hsa:29085
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is: Q9P019
boundary condition: true

metaR r2355
name: Organic anion transporter 5 Utilized transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#

metaM dhap c
is: C00111
name: Dihydroxyacetone phosphate
is: HMDB01473
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57642
is: SBO:0000247
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_44596ad0_0fe1_457d_a1bd_33186087cc68
name: SULT1A1
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6817

http://identifiers.org/biomodels.db/MODEL1310110046#_ead95689_d097_49de_ad05_df97414faa34
is: SBO:0000252
name: SLC17A3
is encoded by: hsa:10786
has only substance units: false
is: O00476
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR CITL
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110046#
reversible: false
name: Citrate lyase
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_f2741a25_1970_4857_bda4_f192fc93ed28
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2582
boundary condition: true
is: SBO:0000252
is: Q14376
name: GALE
has only substance units: false

metaM 2dodtricoa x
is: C05279
name: 2,6,9-dodecatrienoylcoa
initial concentration: 1.0
boundary condition: false
is: HMDB11123
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
has only substance units: false

metaM hs deg25 l
is: SBO:0000247
constant: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H37O21 CHARGE: -1
initial amount: NaN
is: CHEBI:16126
boundary condition: false

metaM ksi deg2 l
constant: false
is: CHEBI:30825
name: keratan sulfate I, degradation product 2
boundary condition: false
type: Species
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
has only substance units: false
is: HMDB00573
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR r0834
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110046#
type: Reaction

metaM lcts g
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: HMDB00186
is: CHEBI:17716
name: lactose
boundary condition: false
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_6e6c8c56_5f2e_44e1_91dc_4fc816d22744
initial concentration: NaN
type: Species
is: SBO:0000252
is: P45954
name: ACADSB
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:36

metaR PI45PLC
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction

metaR NACHEXA16ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000000
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal

metaR ORPT
reversible: true
modifier: MODEL1310110046#
name: orotate phosphoribosyltransferase
fast: false
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.10
is described by: ECO:0000269
reactant: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:

metaM asn L m
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00168
name: L-asparagine
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0

metaR r2354
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110046#
reversible: true

metaM gcald c
name: glycolaldehyde
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: HMDB03344
has only substance units: false
is: SBO:0000247
is: CHEBI:17071
type: Species

metaM dolglcp L r
is: CHEBI:15812
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110046#_daf0c116_7228_4457_a9dc_8f7839817378
initial amount: NaN
is: Q06203
has only substance units: false
name: PPAT
is encoded by: hsa:5471
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaR ILELAT1tc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR CMPSAS
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43
type: Reaction
reversible: false
product: MODEL1310110046#
is: SBO:0000176
name: CMP sialic acid synthase
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
fast: false
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_a0965fad_3d59_4b25_916e_a9478ddb34f4
is: Q00796
boundary condition: true
initial concentration: NaN
name: SORD
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6652
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_157750da_3b62_4ea2_8514_3f61a7a02eea
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:122622
name: ADSSL1
is: B3KTV4
constant: false
type: Species

metaM 4hphac e
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 4-hydroxyphenylacetate
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: HMDB00020
is: CHEBI:48999
initial amount: NaN
type: Species
boundary condition: false

metaR ASNGLNNaEx
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000269
modifier: MODEL1310110046#
is: SBO:0000185

metaM dhap e
constant: false
is: HMDB01473
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57642
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
name: glycerone phosphate(2-)
boundary condition: false

metaR RE3346C
is: SBO:0000176
reversible: true
name: RE3346
reactant: MODEL1310110046#
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110046#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110046#_e523056f_6835_40b0_9837_524cc76852f2
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6647
boundary condition: true
is: P00441
constant: false
initial amount: NaN
is: SBO:0000252
name: SOD1

metaR AICARte
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110046#
product: MODEL1310110046#
fast: false
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reactant: MODEL1310110046#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110046#_f3824343_caef_40ae_b48f_8dec4c20fdf1
initial concentration: NaN
has only substance units: false
name: FUCA1
initial amount: NaN
is encoded by: hsa:2517
is: P04066
constant: false
boundary condition: true
is: SBO:0000252
type: Species

metaR r2353
type: Reaction
reactant: MODEL1310110046#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110046#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110046#

metaR RE1533M
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1533
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reactant: MODEL1310110046#

metaM oxa m
has only substance units: false
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
name: oxalate(2-)
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:30623

metaR r0722
reversible: true
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/4.2.3.12
type: Reaction
fast: false
modifier: MODEL1310110046#
product: MODEL1310110046#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176

metaR G14T10g
is described by: ECO:0000000
type: Reaction
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM 10fthf c
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
is: HMDB00972
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR COAtr
product: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#
type: Reaction
name: COA transporter, endoplasmic reticulum
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false

metaR C4CRNCPT2
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
type: Species
constant: false
is: HMDB01166
has only substance units: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57316
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM na1 r
initial concentration: 1.0
is: HMDB00588
type: Species
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:29101
name: sodium(1+)
is: SBO:0000247

metaR MM6B2g
product: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
modifier: MODEL1310110046#

metaR r2352
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110046#

metaR FAOXC163GC142m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM pa hs c
has only substance units: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247
type: Species
is: CHEBI:57739
name: phosphatidate(2-)
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM drib c
initial concentration: 1.0
has only substance units: false
type: Species
name: 2-deoxy-D-ribose
is: CHEBI:28816
is: HMDB03224
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
constant: false
is: SBO:0000247

metaR RE2659R
reversible: true
is described by: ECO:0000000
product: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
name: RE2659
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110046#
fast: false
type: Reaction

metaM pmtcoa m
type: Species
boundary condition: false
constant: false
is: HMDB01338
initial amount: NaN
has only substance units: false
is: CHEBI:57379
is: C00154
is: SBO:0000247
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

metaM asn L c
name: L-asparagine
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00168
initial amount: NaN
is: CHEBI:17196

metaR LEUTAm
is described by: ECO:0000269
fast: false
name: leucine transaminase, mitochondrial
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true

metaR HSD3A2r
modifier: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110046#
is described by: ECO:0000000

metaR r0723
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110046#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110046#

metaM prostgd2 r
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
name: prostaglandin D2(1-)
type: Species
constant: false
is: HMDB01403
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_6e985a76_e52a_46e7_bda7_9f79470ea898
is encoded by: hsa:8612
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is: E9PAY8
initial amount: NaN
name: PPAP2C

http://identifiers.org/biomodels.db/MODEL1310110046#_cf01da28_d534_4814_a275_d9f817d0a72e
is: Q9GZS9
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: CHST5
boundary condition: true
type: Species
is encoded by: hsa:23563

metaM 4hphac c
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: 4-hydroxyphenylacetate
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: HMDB00020
is: SBO:0000247
boundary condition: false
is: CHEBI:48999
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_45725e4d_d242_4f6a_b1bc_7cf28fba170e
is: O94777
initial concentration: NaN
is encoded by: hsa:8818
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: DPM2

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_e6da7cbb_e5ea_43b1_8327_395a7980b070
initial amount: NaN
type: Species
boundary condition: true
name: _AA177072_1_x
has only substance units: false
is encoded by: hsa:AA177072
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_8494e338_e384_49c0_ab89_afae04ce83d9
boundary condition: true
is: SBO:0000252
is: Q96PE7
name: MCEE
is encoded by: hsa:84693
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM imp e
constant: false
is: HMDB00175
boundary condition: false
name: IMP(2-)
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial amount: NaN

metaM dcacoa c
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
has only substance units: false
is: HMDB06404
initial amount: NaN
type: Species
is: CHEBI:61430
boundary condition: false
constant: false
is: SBO:0000247

metaR GALtly
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000000
name: galactose efflux from lysosome
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110046#_36b4de5c_d4f7_41ea_b182_47100bfef3ed
has part: P12074
is encoded by: hsa:9167
initial amount: NaN
has part: P20674
has part: Q53XN1
is encoded by: hsa:1340
has part: P24311
is encoded by: hsa:125965
is encoded by: hsa:170712
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P24310
is encoded by: hsa:4514
has part: Q8TF08
has part: P09669
is encoded by: hsa:1347
is encoded by: hsa:1346
has part: Q6FGA0
is: SBO:0000297
has part: Q6YFQ2
has part: Q02221
is encoded by: hsa:9377
type: Species
has part: Q7Z4L0
initial concentration: NaN
is encoded by: hsa:84701
is encoded by: hsa:1349
has part: Q7GXY8
has part: H0UI06
is encoded by: hsa:1350
has part: P15954
is encoded by: hsa:1337
is encoded by: hsa:341947
has part: Q7GXZ8
has part: Q53YB7
has part: P13073
has only substance units: false
is encoded by: hsa:1351
has part: P14854
has part: P00414
boundary condition: true
is encoded by: hsa:4513
is encoded by: hsa:4512
constant: false
is encoded by: hsa:1327
is encoded by: hsa:1345
has part: Q96KJ9
is encoded by: hsa:1339
is encoded by: hsa:1329

metaR r1945
modifier: MODEL1310110046#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
fast: false
name: Y+LAT2 Utilized transport
reversible: false

metaR C226COAtx
type: Reaction
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
name: fatty acid intracellular transport
reactant: MODEL1310110046#
is: SBO:0000185
reversible: true

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
reactant: MODEL1310110046#
reversible: true
is: SBO:0000176
product: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.33

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_ec9d486d_34ea_4e06_8a9f_8aadce600c06
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: P22392
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4831
type: Species
name: NME2

metaR HSD3B12r
kinetic law: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
fast: false
is described by: ECO:0000134
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110046#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_de5ab875_1c3a_45cf_83e8_cd1510d65803
has only substance units: false
has part: Q53G02
is encoded by: hsa:6185
initial amount: NaN
has part: P04843
is encoded by: hsa:1603
has part: P04844
is: SBO:0000297
type: Species
constant: false
has part: P39656
boundary condition: true
is encoded by: hsa:1650
initial concentration: NaN
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:6184

metaM lnlncacoa m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: HMDB06290
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:51985
has only substance units: false
initial concentration: 1.0
name: alpha-Linolenoyl-CoA
type: Species
constant: false

metaM 5tedtricoa x
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
name: 5,8,11-tetradecatrienoylcoa
boundary condition: false
has only substance units: false
is: HMDB02288
initial concentration: 1.0
type: Species
constant: false

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaR S23T4g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: beta-galactoside alpha-2,3-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.4
fast: false
modifier: MODEL1310110046#
type: Reaction
product: MODEL1310110046#

metaR ACACT5p
modifier: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110046#
is: SBO:0000176
kinetic law: MODEL1310110046#
reversible: false
is described by: ECO:0000269
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110046#_34a2cc37_465c_4286_8032_2c044469e685
name: _AI990637_1_x
has only substance units: false
constant: false
is encoded by: hsa:AI990637
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR ENGASE3ly
is described by: ECO:0000000
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
is: SBO:0000176

metaR FAOXC201C181x
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR RDH1
modifier: MODEL1310110046#
name: retinol dehydrogenase (all-trans)
is described by: ECO:0000269
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110046#_2c05df51_fe11_4c21_977e_cdaba9653d21
is: P35219
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:767
type: Species
constant: false
initial concentration: NaN
name: CA8

metaR COAtm
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
fast: false
kinetic law: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110046#
reversible: true
modifier: MODEL1310110046#
name: CoA transporter
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_8e54f7e7_c193_49cf_91ed_bc616eca9f1e
is: SBO:0000252
name: PIK3CA
has only substance units: false
is: P42336
boundary condition: true
is encoded by: hsa:5290
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR r0726
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110046#
modifier: MODEL1310110046#
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000

metaR GLYAMDTRc
modifier: MODEL1310110046#
is described by: ECO:0000269
name: glycine amidinotransferase (c)
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.1.4.1
reversible: true
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
type: Reaction
is: SBO:0000176

metaM inost c
is: SBO:0000247
name: myo-inositol
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:17268
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
is: HMDB00211
boundary condition: false

metaR MM8Ber
product: MODEL1310110046#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_3d037156_73aa_49ed_ba28_2b5af789be16
name: SULT2B1
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6820
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_c1ce0344_4414_4679_908d_12d1df565793
initial amount: NaN
is: Q86XP1
initial concentration: NaN
name: DGKH
type: Species
has only substance units: false
is encoded by: hsa:160851
is: SBO:0000252
boundary condition: true
constant: false

metaR r0839
product: MODEL1310110046#
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110046#
is: SBO:0000185
fast: false
is described by: ECO:0000000
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_25afd130_c3bd_4a79_a590_62a8f2058d29
name: _NOS2A_1_c
is encoded by: hsa:NOS2A
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR RDH2
name: retinol dehydrogenase (9-cis,NADH)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
fast: false

metaR PAPtg
reversible: false
name: adenosine 3',5'-bisphosphate Golgi transport
kinetic law: MODEL1310110046#
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR COAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110046#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
name: coenzyme A transport, nuclear
kinetic law: MODEL1310110046#
product: MODEL1310110046#

metaR DTDPtn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110046#
name: dTDP nuclear transport
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_34162466_28be_4f16_b993_c21a04ebe77e
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P53794
type: Species
is encoded by: hsa:6526
is: SBO:0000252
name: SLC5A3

metaM paf hs e
is: CHEBI:36707
has only substance units: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

metaR HMGLm
is version of: http://identifiers.org/ec-code/4.1.3.4
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
name: hydroxymethylglutaryl-CoA lyase
fast: false
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
is described by: ECO:0000134

metaM nicrnt c
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: CHEBI:57502
has only substance units: false
name: Nicotinate D-ribonucleotide
is: HMDB01132
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: C01185

metaR H3ETer
product: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000304
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110046#
type: Reaction
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum

metaR EX c12dc
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecanedioyl carnitine
type: Reaction

metaR ELAIDCPT1
modifier: MODEL1310110046#
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110046#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110046#
is described by: ECO:0000269
type: Reaction

metaR ARACHDtr
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
reversible: true
is: SBO:0000185
name: intracellular transport
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_1d8f59cc_2426_41cc_95be_c3baa3f308a2
boundary condition: true
has only substance units: false
initial amount: NaN
name: ACAA1
is encoded by: hsa:30
type: Species
is: SBO:0000252
constant: false
is: Q96CA6
initial concentration: NaN

metaR PPDOy
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110046#

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaM 3hpcoa m
is: CHEBI:58528
initial concentration: 1.0
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB06807
constant: false
name: 3-hydroxypropanoyl-CoA(4-)
has only substance units: false
boundary condition: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_ddf48f4c_d4e0_4e1b_8173_52bff0973964
constant: false
boundary condition: true
type: Species
is: Q14032
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: BAAT
is encoded by: hsa:570
has only substance units: false

metaM hestratriol r
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 4,17 dihydroxy estradiol
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: HMDB05896

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR ELAIDCPT2
name: carnitine transferase
kinetic law: MODEL1310110046#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_05ade4e5_6755_4a8f_b280_33d05d19f758
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA664770
has only substance units: false
initial amount: NaN
name: _AA664770_1_m
type: Species
constant: false

metaM inost e
type: Species
is: SBO:0000247
name: myo-inositol
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00211
is: CHEBI:17268

metaR r0728
product: MODEL1310110046#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reversible: true
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
is described by: ECO:0000000

metaM octdececrn m
is: SBO:0000247
is: HMDB06351
has only substance units: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

metaR PPDOx
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
reactant: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
product: MODEL1310110046#
reversible: false
kinetic law: MODEL1310110046#
is described by: ECO:0000269
fast: false

metaM tettet6coa x
name: tetracosatetraenoyl coenzyme A
is: SBO:0000247
initial concentration: 1.0
is: C16171
is: HMDB06516
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/47205481
boundary condition: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1

metaR FAOXC101m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaM arachcoa m
name: arachidyl coenzyme A
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:15527
initial concentration: 1.0
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041

metaR RE1897C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110046#
reversible: true
name: RE1897

http://identifiers.org/biomodels.db/MODEL1310110046#_c427ca1c_7adc_4ea8_be6c_ce2d5809c5cd
is: Q96CA6
is encoded by: hsa:30
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: ACAA1

metaM gln L m
name: L-glutamine
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:18050
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
has only substance units: false

metaR COAtp
reactant: MODEL1310110046#
name: coenzyme A transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110046#
kinetic law: MODEL1310110046#
is described by: ECO:0000000

metaM trdox m
type: Species
has only substance units: false
is: SBO:0000247
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
initial amount: NaN
is: CHEBI:18191
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_395ab789_9fad_4e00_881d_cd69c14fdc18
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: P43353
is encoded by: hsa:221
type: Species
boundary condition: true
name: ALDH3B1

metaR FAOXC2452256x
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
name: Beta oxidation of long chain fatty acid
reversible: false
type: Reaction

metaM asn L e
name: L-asparagine
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00168
initial amount: NaN
is: CHEBI:17196
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_ca5d6377_c37b_4d97_867e_f2c4a1f8fb60
is: Q86VV3
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: ENTPD1
type: Species
boundary condition: true
is encoded by: hsa:953
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_61d98dc4_381d_4148_8099_e2e476351276
is: P12277
is: SBO:0000252
is encoded by: hsa:1152
constant: false
name: CKB
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR C204CPT2
modifier: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
name: arachidonic acid transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_52451cce_bfad_4dec_b44e_8c8203a4d6e9
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: Q6LEN6
is encoded by: hsa:1103
type: Species
name: CHAT
has only substance units: false
boundary condition: true

metaR PHYHx
type: Reaction
fast: false
product: MODEL1310110046#
reversible: false
is: SBO:0000176
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.14.11.18
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
kinetic law: MODEL1310110046#
name: Phytanoyl-CoA dioxygenase, peroxisomal
modifier: MODEL1310110046#

metaR AMPtp
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
name: AMP transporter, peroxisome
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_197ac404_d4dc_45df_bf62_b72f0cfec749
name: SLC27A3
is: Q5K4L6
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:11000
type: Species
constant: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_f7e17536_a0d5_409c_8d55_e5f369806a1d
is: B1AM93
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4702
constant: false
boundary condition: true
name: NDUFA8
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_1dbdd95d_dd82_46ca_be5e_7659159e726e
initial concentration: NaN
initial amount: NaN
type: Species
name: PECR
is encoded by: hsa:55825
boundary condition: true
is: Q9BY49
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_efb5d5e5_1b7e_4bdf_be81_0d1cd6da9a30
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P00390
is encoded by: hsa:2936
boundary condition: true
is: SBO:0000252
constant: false
name: GSR
type: Species

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_e43924f1_c5f1_439a_b59c_1a20bcab0d13
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5091
is: SBO:0000252
is: P11498
initial amount: NaN
name: PC
type: Species
has only substance units: false
constant: false

metaR NDPK8n
reversible: true
modifier: MODEL1310110046#
is described by: ECO:0000304
is: SBO:0000176
kinetic law: MODEL1310110046#
type: Reaction
fast: false
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110046#

metaM 3otdcoa m
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
name: 3-Oxotetradecanoyl-CoA
is: HMDB03935
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28726
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_e50025f1_9567_44b6_ada5_8f6f6721c2e0
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _22305_2_c
is encoded by: hsa:22305

http://identifiers.org/biomodels.db/MODEL1310110046#_c833562c_d8bb_4d9d_aa77_6f5d52d7e01e
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:124454
is: Q5JPH6
boundary condition: true
initial amount: NaN
name: EARS2

metaR DHORD9
name: dihydoorotic acid dehydrogenase (quinone10)
reversible: false
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.5.2
fast: false
is described by: ECO:0000269

metaM thr L e
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
is: SBO:0000247
name: L-threonine
type: Species
constant: false

metaM mercplaccys c
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
type: Species

metaR COQ5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
fast: false
kinetic law: MODEL1310110046#
name: Ubiquinone biosynthesis methyltransferase COQ5
type: Reaction
reactant: MODEL1310110046#
reversible: false
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000000

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110046#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110046#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
reactant: MODEL1310110046#

metaR PMTCOAtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110046#
reversible: true
kinetic law: MODEL1310110046#
is: SBO:0000185
type: Reaction
product: MODEL1310110046#
name: fatty acid intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_8e5e623e_eefa_4cdd_be13_2807cc84519f
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: PDE8A
type: Species
initial amount: NaN
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110046#_1ef1707e_5a3f_4bda_a89e_44b585451857
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q9HAB8
name: PPCS
is encoded by: hsa:79717
is: SBO:0000252

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR r0456
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110046#
is: SBO:0000176
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
reversible: false
product: MODEL1310110046#
type: Reaction
kinetic law: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.32

metaR CAt7r
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
is described by: ECO:0000269
name: calcium / sodium antiporter (1:3), reversible
reversible: true
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
reactant: MODEL1310110046#
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_fd30b9d6_d5c7_4903_8422_a2751bb2c42c
is: Q9H2M3
name: BHMT2
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:23743

metaM pa hs m
has only substance units: false
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaR FAOXC81C61m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR PTDCAt
reversible: true
is: SBO:0000185
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_89f1e566_b870_4bef_a7b6_ed16d8a4c256
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56301
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q9NS82
has only substance units: false
name: SLC7A10

metaM datp m
initial concentration: 1.0
is: SBO:0000247
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
is: C00131
is: HMDB01532
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:61404

metaR DMNONCOACRNCPT1
reversible: true
is described by: ECO:0000000
name: DMNONCOACRNCPT1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
product: MODEL1310110046#
fast: false
is: SBO:0000176
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaM cholcoaone x
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58507
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: HMDB06891
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_10c83443_daf6_43c8_908a_e3879e6b2e8d
initial concentration: NaN
constant: false
has only substance units: false
name: GUCY2F
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:2986
type: Species
is: P51841

metaM paps g
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial amount: NaN
is: HMDB01134
type: Species
boundary condition: false
is: CHEBI:58339
is: SBO:0000247
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

metaM na1 x
is: CHEBI:29101
constant: false
name: sodium(1+)
boundary condition: false
initial amount: NaN
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
type: Species
is: HMDB00588
is: SBO:0000247
initial concentration: 1.0

metaR FACOAL2042
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is described by: ECO:0000000
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
fast: false
name: fatty-acid--CoA ligase
reversible: true
product: MODEL1310110046#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR TAGt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110046#
fast: false
reactant: MODEL1310110046#
product: MODEL1310110046#
name: triacylglycerol transport
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_182c7b97_80d8_4b58_80bc_ad22156ab6bc
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: GALE
is: Q38G75
is encoded by: hsa:2582
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR RE2954C
is: SBO:0000176
kinetic law: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: RE2954

http://identifiers.org/biomodels.db/MODEL1310110046#_0d55566a_f98c_40ba_afdf_c00669346ba2
type: Species
initial amount: NaN
is encoded by: hsa:23428
has only substance units: false
boundary condition: true
has part: Q86U05
is: SBO:0000297
name: SLC7A8:SLC3A2
constant: false
initial concentration: NaN

metaR AKGtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110046#
name: AKG transporter, peroxisome
kinetic law: MODEL1310110046#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110046#
is: SBO:0000185
reversible: true

metaM CE2420 m
initial concentration: 1.0
constant: false
is: CHEBI:28387
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB11123
type: Species
has only substance units: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420

metaR PYDAMK
product: MODEL1310110046#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.35
fast: false
reactant: MODEL1310110046#
name: pyridoxamine kinase
kinetic law: MODEL1310110046#
type: Reaction
modifier: MODEL1310110046#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110046#_75e1ae44_dfc5_4ad5_9f0c_f6e20dbf5ff7
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8897
initial concentration: NaN
name: MTMR3
type: Species
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_ce7b74ee_702f_4860_ae19_0ced6d121171
initial concentration: NaN
is: SBO:0000252
type: Species
is: P49748
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: ACADVL
is encoded by: hsa:37

metaM datp n
name: dATP
is: HMDB01532
is: SBO:0000247
is: CHEBI:61404
boundary condition: false
constant: false
is: C00131
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_672c1ba6_c663_4ca2_a0eb_54ad44f9bac4
name: _NM_001929_1_c
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:NM 001929
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_adee7b01_7d9d_4908_b8bb_66bba0b24175
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9NWU1
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:54995
initial concentration: NaN
name: OXSM

metaM thr L c
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: L-threonine
is: HMDB00167

http://identifiers.org/biomodels.db/MODEL1310110046#_672fc365_1ddf_47b8_adb6_7670acbe69d5
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4714
has only substance units: false
is: O95169
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: NDUFB8

metaM cholcoads x
is: SBO:0000247
has only substance units: false
is: CHEBI:27505
is: HMDB06889
constant: false
type: Species
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM HC02175 e
name: caprate
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
initial concentration: 1.0

metaM biocyt c
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
is: C05552
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: Biocytin
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886

metaM g1m8masn r
boundary condition: false
is: C05875
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: SBO:0000247

metaR GALt4
kinetic law: MODEL1310110046#
reversible: true
is: SBO:0000185
name: galactose transport via sodium symport
reactant: MODEL1310110046#
modifier: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
is described by: ECO:0000269
type: Reaction

metaM arachcoa x
initial amount: NaN
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15527
is: HMDB04258
boundary condition: false
has only substance units: false

metaR SCP22x
is described by: ECO:0000000
product: MODEL1310110046#
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110046#
name: Sterol carrier protein 2
fast: false
reactant: MODEL1310110046#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_772763d8_c81a_4650_832b_2b0639f144bc
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:NM 013421
has only substance units: false
name: _NM_013421_1_e
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_d614086f_3252_4c25_895d_0a847cf546ee
has only substance units: false
is encoded by: hsa:8704
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: O60909
type: Species
name: B4GALT2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_eac8c427_4444_4cd6_b984_49b4cbece9b3
is: A0PJK1
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: SLC5A10
initial concentration: NaN
is encoded by: hsa:125206
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_7faca08c_aa91_4b43_8324_d4c4aa8ffc0a
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:549
constant: false
is: Q13825
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: AUH

metaM imp c
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: IMP
is: C00130
constant: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175

metaR TMNDNCCPT2
is: SBO:0000176
reactant: MODEL1310110046#
name: carnitine transferase
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110046#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110046#
fast: false

metaM ksi pre7 g
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
type: Species
initial concentration: 1.0
is: HMDB00175
has only substance units: false
is: C00130
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 7
notes: FORMULA: C115H187N8O85SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110046#_2d9ed646_9409_4490_9d52_7358ae1a9db3
is: SBO:0000252
name: DGKG
initial concentration: NaN
is encoded by: hsa:1608
boundary condition: true
constant: false
initial amount: NaN
is: P49619
has only substance units: false
type: Species

metaM HC01361 e
initial amount: NaN
is: CHEBI:17001
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: Dihydroneopterin
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
is: SBO:0000247
has only substance units: false

metaM retinal 11 cis c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16066
is: HMDB02152
name: 11-cis-retinal
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false

metaM drib e
name: 2-deoxy-D-ribose
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:28816
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: HMDB03224

http://identifiers.org/biomodels.db/MODEL1310110046#_40137e57_1899_40ca_b49d_ade1dceb51c4
is: F8WDN9
constant: false
initial amount: NaN
type: Species
name: PPA2
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:27068
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_ec6e080c_b1fe_4916_889c_cf6e423decf6
boundary condition: true
is: P14550
name: AKR1A1
initial amount: NaN
has only substance units: false
is encoded by: hsa:10327
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110046#_63bb7332_9a83_4b90_97db_f4e050696b3e
initial concentration: NaN
type: Species
is: Q9UHW9
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:9990
name: SLC12A6
has only substance units: false
constant: false

metaM ksi pre30 g
is: SBO:0000247
is: C00130
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 30
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:58053
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
boundary condition: false

metaR DCYTD
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110046#
product: MODEL1310110046#
name: deoxycytidine deaminase
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110046#
fast: false
type: Reaction

metaM gln L e
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00641
name: L-glutamine

metaM 6thf e
is: http://identifiers.org/pubchem.compound/169691
boundary condition: false
type: Species
name: hexaglutamyl folate (THF)
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
has only substance units: false
initial amount: NaN

metaM dcacoa x
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:61430
is: HMDB06404
boundary condition: false
is: C05274
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)
type: Species
constant: false
has only substance units: false

metaM paps c
is: CHEBI:58339
has only substance units: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
constant: false
is: HMDB01134
type: Species
is: SBO:0000247
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR TMNDNCCPT1
reversible: false
reactant: MODEL1310110046#
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
fast: false
product: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110046#_3bab086c_60c8_4ee7_ad4f_180b958aad49
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
name: _HG2846_HT2983_1_m
initial concentration: NaN
has only substance units: false

metaM mercplaccys e
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 3-mercaptolactate-cysteine disulfide
is: HMDB06512
constant: false
boundary condition: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110046#_3969b07e_404d_460b_b400_7384cd27548f
is: SBO:0000252
is encoded by: hsa:4668
boundary condition: true
type: Species
initial concentration: NaN
is: P17050
constant: false
name: NAGA
has only substance units: false
initial amount: NaN

metaR r0720
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#

metaR DMHPTCRNt
product: MODEL1310110046#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110046#
reversible: true
is: SBO:0000185
fast: false
name: 2,6 dimethylheptanoyl crn transport
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ

metaM cytd m
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247
is: CHEBI:17562
name: cytidine
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00089

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR GLYSARCNc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaR DNDPt25m
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
reversible: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
name: dTDP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR BTNPL
product: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase)
is described by: ECO:0000000
kinetic law: MODEL1310110046#
fast: false
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110046#

metaR S6TASE25ly
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
kinetic law: MODEL1310110046#
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110046#

metaR TMDS
reversible: false
reactant: MODEL1310110046#
fast: false
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.45
is: SBO:0000176
name: thymidylate synthase
modifier: MODEL1310110046#
product: MODEL1310110046#
type: Reaction

metaR RE1691M
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.8.1.1
product: MODEL1310110046#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
is described by: ECO:0000000
name: RE1691
fast: false

metaR GLYCt
type: Reaction
name: glycerol transport via channel
reactant: MODEL1310110046#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR 5OXPROt
reversible: true
is: SBO:0000185
name: Transport of 5-oxoprolinate
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110046#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110046#_aaf99cd0_05f0_4e42_852d_1cf63315b9de
boundary condition: true
initial concentration: NaN
is encoded by: hsa:160728
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: SLC5A8
has only substance units: false
is: Q8N695

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM dolglcp L c
has only substance units: false
initial amount: NaN
is: CHEBI:15812
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog

metaR PGCD
reactant: MODEL1310110046#
reversible: false
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
type: Reaction
kinetic law: MODEL1310110046#
name: phosphoglycerate dehydrogenase
is described by: ECO:0000269
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/1.1.1.95
is: SBO:0000176
fast: false
product: MODEL1310110046#

metaM gln L c
initial amount: NaN
initial concentration: 1.0
is: HMDB00641
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
is: CHEBI:18050
name: L-glutamine
type: Species
is: SBO:0000247

metaM trdox c
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: SBO:0000247
is: CHEBI:18191
boundary condition: false
name: Oxidized thioredoxin
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: C00343

metaR TYRTA
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110046#
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176

metaM cytd c
is: C00475
is: CHEBI:17562
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
type: Species

metaM dc2coa m
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:61406
name: trans-Dec-2-enoyl-CoA
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
constant: false

metaR LPCHOLt
is described by: ECO:0000000
name: lysophosphatidylcholine transport
product: MODEL1310110046#
kinetic law: MODEL1310110046#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_153cc037_4387_4f29_acdc_71b741d30ed0
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AI915649
has only substance units: false
type: Species
initial concentration: NaN
name: _AI915649_1_c

metaR GALASE9ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110046#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR GLXtm
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110046#
reversible: true
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
name: glyoxylate transport, mitochondrial

metaR DHCHOLESTANATEtm
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000000
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110046#

metaM ile L c
name: L-isoleucine
is: HMDB00172
is: CHEBI:17191
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

http://identifiers.org/biomodels.db/MODEL1310110046#_46fc30a1_b517_410e_bfbf_e9867166737b
is: O60825
type: Species
boundary condition: true
name: PFKFB2
is encoded by: hsa:5208
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR DNDPt14m
modifier: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
name: dUDP transport via dTDP antiport
type: Reaction
reversible: false
kinetic law: MODEL1310110046#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110046#_bb371c80_efcc_4a98_ba71_872e03d3759e
constant: false
boundary condition: true
initial amount: NaN
is: B4DG68
has only substance units: false
is encoded by: hsa:4842
is: SBO:0000252
type: Species
initial concentration: NaN
name: NOS1

metaR LEUtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
fast: false
reversible: true
name: L-leucine transport via diffusion (extracellular to cytosol)
product: MODEL1310110046#
type: Reaction
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110046#_b5277468_130d_466f_8f87_e8a063525066
is encoded by: hsa:5151
boundary condition: true
type: Species
name: PDE8A
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR BHMT
kinetic law: MODEL1310110046#
fast: false
product: MODEL1310110046#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.5
is: SBO:0000176
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (23743.1) or (635.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.5 Confidence Level: 4 AUTHORS: PMID:9281325 NOTES:
modifier: MODEL1310110046#
is described by: ECO:0000269
name: betaine-homocysteine S-methyltransferase

metaM acgam6p c
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01062
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
boundary condition: false
initial amount: NaN
is: CHEBI:57513
name: N-acetyl-D-glucosamine 6-phosphate(2-)
has only substance units: false

metaM dhap x
name: Dihydroxyacetone phosphate
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411
type: Species
is: CHEBI:57642
is: C00111
boundary condition: false
initial concentration: 1.0
is: HMDB01473
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d7f9f7f8_8807_4f27_931a_19a8cb650267
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: P27987
name: ITPKB
boundary condition: true
is encoded by: hsa:3707
is: SBO:0000252

metaR GLXtp
is described by: ECO:0000000
fast: false
reversible: true
name: glyoxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
product: MODEL1310110046#

metaM ksi pre17 g
initial amount: NaN
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 17
initial concentration: 1.0
is: CHEBI:28067
constant: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
has only substance units: false
boundary condition: false

metaM HC02175 c
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:27689

metaR r0830
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110046#
is described by: ECO:0000000
product: MODEL1310110046#
reactant: MODEL1310110046#
modifier: MODEL1310110046#
type: Reaction
is: SBO:0000185

metaM glutcoa m
initial amount: NaN
is: SBO:0000247
is: CHEBI:57378
initial concentration: 1.0
constant: false
name: glutaryl-CoA(5-)
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: HMDB01339
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_097c4d3b_3a2f_4fcc_b99c_ec1e62c5f07b
name: IDS
is encoded by: hsa:3423
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: P22304
initial concentration: NaN

metaM pap g
name: adenosine 3',5'-bismonophosphate(4-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
has only substance units: false
is: CHEBI:58343
type: Species
is: HMDB00061
boundary condition: false
initial concentration: 1.0
constant: false

metaR r0560
is described by: ECO:0000000
reactant: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
type: Reaction
reversible: false

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_3daafe97_4c9e_468b_bc2d_f03f682e628e
initial amount: NaN
name: PCCA:PCCB
boundary condition: true
has only substance units: false
type: Species
has part: C9JPQ8
is encoded by: hsa:5096
initial concentration: NaN
constant: false
has part: P05166
is: SBO:0000297
is encoded by: hsa:5095

http://identifiers.org/biomodels.db/MODEL1310110046#_284a5f19_a085_4674_af20_d4ab21bdd6d4
is: O75912
name: DGKI
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9162
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR GLCNACASE1ly
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110046#
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

metaM ile L e
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
is: SBO:0000247
initial amount: NaN
name: L-isoleucine
is: CHEBI:17191
initial concentration: 1.0
type: Species

metaR RTOTALFATPc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110046#_45f315ca_dd54_40aa_bdb9_57eaaeb2e9af
name: NT5M
is encoded by: hsa:56953
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q9NPB1
type: Species
initial amount: NaN
is: SBO:0000252

metaM nrvnccoa x
has only substance units: false
is: SBO:0000247
name: nervonyl coenzyme A
initial amount: NaN
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
constant: false
is: C16532
type: Species
boundary condition: false
initial concentration: 1.0

metaR S2TASE3ly
fast: false
reversible: false
product: MODEL1310110046#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/3.1.6.13
kinetic law: MODEL1310110046#
reactant: MODEL1310110046#
name: iduronate-2-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110046#_bea58e97_7df7_4adf_9c99_3a2991ba4d5f
boundary condition: true
initial amount: NaN
is encoded by: hsa:9374
is: SBO:0000252
initial concentration: NaN
name: PPT2
type: Species
has only substance units: false
constant: false
is: Q9UMR5

metaM CE2416 x
is: CHEBI:57923
name: (2R,6S,10S)-pristanate
type: Species
initial concentration: 1.0
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM HC01409 m
has only substance units: false
boundary condition: false
is: CHEBI:27540
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
constant: false
is: SBO:0000247
initial amount: NaN
name: Hexanoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110046#_ad6edd91_0fdb_42a9_8e30_e793eb68ab11
is: Q9NY64
constant: false
type: Species
name: SLC2A8
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:29988
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_fbde8803_dbeb_43e4_acbf_26cd9523e7f6
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:126
constant: false
name: ADH1C
type: Species
has only substance units: false
is: P00326

metaM HC02205 c
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
initial concentration: 1.0
constant: false
name: prostaglandin-b2
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:28099

http://identifiers.org/biomodels.db/MODEL1310110046#_da834464_5cd9_488d_ac2f_33b0d9249e34
is: SBO:0000252
type: Species
initial amount: NaN
name: PDE8A
is: H0YMZ7
is encoded by: hsa:5151
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110046#_61a69d83_0f58_425e_a91b_82546b3d8aec
constant: false
name: OGDH
is: B4E3E9
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4967

metaR RE0456M
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
name: RE0456
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
fast: false
product: MODEL1310110046#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_1a9d56f1_95b3_4158_af89_bf1d457f567f
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9791
type: Species
constant: false
name: PTDSS1
initial concentration: NaN
has only substance units: false
is: P48651
boundary condition: true

metaR DGCHOLtx
reactant: MODEL1310110046#
is described by: ECO:0000000
kinetic law: MODEL1310110046#
product: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is: SBO:0000185
fast: false
type: Reaction
name: bile acid intracellular transport

metaM dcacoa m
is: C05274
is: HMDB06404
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
type: Species
initial amount: NaN
is: CHEBI:61430
boundary condition: false
constant: false

metaM pa hs n
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739

metaM 2dpmhobq m
initial concentration: 1.0
is: HMDB06484
boundary condition: false
type: Species
constant: false
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: CHEBI:50771

metaR UDPGALtg
modifier: MODEL1310110046#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110046#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
name: UDP-Gal Golgi transport via CMP antiport
product: MODEL1310110046#
kinetic law: MODEL1310110046#

metaR ECOAH9m
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110046#
modifier: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is: SBO:0000176
is described by: ECO:0000304

metaR LNLCt
kinetic law: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
name: Linoleic acid (n-C18:2) transport in via diffusion
product: MODEL1310110046#
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR PROSTGE2t
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110046#
type: Reaction
product: MODEL1310110046#

metaM pa hs r
type: Species
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: phosphatidate(2-)
is: CHEBI:57739
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110046#_feccfb25_7458_42b0_bd1b_431e4eb66c85
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P11182
is encoded by: hsa:1629
type: Species
name: DBT

http://identifiers.org/biomodels.db/MODEL1310110046#_aa226f32_f984_477b_aa25_cefd4e88b0c8
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:728226
constant: false
name: _728226_1_e
type: Species
has only substance units: false
initial amount: NaN

metaR NAIt
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
fast: false
name: Na+ / iodide cotransport
type: Reaction
is described by: ECO:0000269
product: MODEL1310110046#
modifier: MODEL1310110046#
reactant: MODEL1310110046#
kinetic law: MODEL1310110046#

metaM ocde9ecoa x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
name: 9-octadecenoylcoa
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaR NACHEXA20ly
modifier: MODEL1310110046#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
reactant: MODEL1310110046#
product: MODEL1310110046#
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_042ada17_c7e0_49f9_bef9_12e89aeb5691
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2653
name: GCSH
type: Species
has only substance units: false
is: SBO:0000252
is: P23434
constant: false
boundary condition: true

metaM pap c
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
is: HMDB00061
is: CHEBI:58343

metaM HC02205 e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: prostaglandin-b2
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
is: CHEBI:28099

metaM cytd e
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Cytidine
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
is: CHEBI:17562
is: C00475

metaM 2dp6mep m
has only substance units: false
type: Species
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
boundary condition: false
is: SBO:0000247
is: CHEBI:50774
initial amount: NaN
constant: false
name: 2-Decaprenyl-6-methoxyphenol
initial concentration: 1.0

metaM 5tedtricoa m
type: Species
is: HMDB02288
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
name: 5,8,11-tetradecatrienoylcoa
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110046#_d6d4ef41_0aa8_44fd_a70d_19f58aad7818
is encoded by: hsa:8394
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q99755
type: Species
constant: false
boundary condition: true
name: PIP5K1A

http://identifiers.org/biomodels.db/MODEL1310110046#_7e547da5_8091_46fb_acd6_d8d5b9b48a13
name: ALDH2
has only substance units: false
is: P05091
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:217
type: Species

metaR FACOAL80i
modifier: MODEL1310110046#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110046#
is: SBO:0000176
reactant: MODEL1310110046#
type: Reaction
name: fatty-acid--CoA ligase (octanoate)
product: MODEL1310110046#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110046#_b423e572_3715_4166_b820_6e98bb2e7af4
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: E9PCI1
is encoded by: hsa:53
boundary condition: true
name: ACP2
constant: false
initial concentration: NaN

metaR FAOXC7C5m
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaR AMPTASECG
is version of: http://identifiers.org/ec-code/3.4.11.2
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.1 Confidence Level: 1 AUTHORS: PMID:12675513 NOTES:SAB. activity measured in cytosol rat liver; IT IS leucine aminopeptidase (EC3.4.11.1) NOT alanyl aminopeptidase EC3.4.11.2 which shows > 80% of the activity; sequence homology rat-human not yet verified; annotation 'extracellular' under B column ERROR
modifier: MODEL1310110046#
product: MODEL1310110046#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110046#
is described by: ECO:0000212
is: SBO:0000176
name: alanyl aminopeptidase (cys-gly)

http://identifiers.org/biomodels.db/MODEL1310110046#_41b715dc_c7bf_44ef_9641_64f3b00b95cc
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P03897
type: Species
has only substance units: false
name: ND3
is encoded by: hsa:4537
constant: false

metaR HEX10
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-glucosamine:ATP)
is: SBO:0000176
reactant: MODEL1310110046#
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110046#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.7.1.1

metaR S6T14g
product: MODEL1310110046#
kinetic law: MODEL1310110046#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110046#
modifier: MODEL1310110046#
is described by: ECO:0000000
reversible: false
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110046#_e234dd49_623d_4028_bbc6_44faf65a04f9
initial amount: NaN
is: Q16881
constant: false
is encoded by: hsa:7296
type: Species
boundary condition: true
name: TXNRD1
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110046#_2db04c50_40dc_4c6c_8861_c3554a8fe510
is: Q6IB80
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: NDUFB3
is encoded by: hsa:4709
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR M1316Mg
product: MODEL1310110046#
reversible: false
reactant: MODEL1310110046#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.114
kinetic law: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9f21d4af_c109_4ed3_afa7_c4c0e563ced0
name: DGKZ
is: G3V0F6
has only substance units: false
type: Species
is encoded by: hsa:8525
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR ORNt3m
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
product: MODEL1310110046#
name: ornithine mitochondrial transport via proton antiport
reversible: true
type: Reaction
modifier: MODEL1310110046#
reactant: MODEL1310110046#
is: SBO:0000185
kinetic law: MODEL1310110046#
fast: false
is described by: ECO:0000269

metaR PRASCS
type: Reaction
reactant: MODEL1310110046#
is version of: http://identifiers.org/ec-code/6.3.2.6
reversible: true
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
modifier: MODEL1310110046#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110046#
product: MODEL1310110046#
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaR OLEICFATPtc
kinetic law: MODEL1310110046#
product: MODEL1310110046#
reactant: MODEL1310110046#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM nad m
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00003
type: Species
is: CHEBI:57540
is: HMDB00902
constant: false
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305

http://identifiers.org/biomodels.db/MODEL1310110046#_095eb15c_551f_467e_87b0_c9ef8e376567
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PDE1A
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5136
is: P54750

metaM prostgf2 e
type: Species
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: HMDB01139
name: prostaglandin F2alpha(1-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57404
initial concentration: 1.0

metaR DOLPMT L
type: Reaction
fast: false
product: MODEL1310110046#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.83
name: Dolichyl-phosphate D-mannosyltransferase (liver)
is: SBO:0000176
reactant: MODEL1310110046#
modifier: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
is described by: ECO:0000000

metaR RE1521M
is: SBO:0000176
reactant: MODEL1310110046#
is described by: ECO:0000000
modifier: MODEL1310110046#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110046#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1521
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110046#_685b1ee5_60e5_422e_8602_1d3713fdec0e
is encoded by: hsa:1717
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q9UBM7
name: DHCR7
constant: false
type: Species
has only substance units: false

metaM dopa e
initial amount: NaN
is: CHEBI:59905
is: SBO:0000247
name: dopaminium(1+)
constant: false
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species

metaM mgacpail hs r
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:7896
type: Species
constant: false
is: C00249
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: HMDB00220
has only substance units: false
is: SBO:0000247

metaR 13DAMPPOX
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is: SBO:0000176
is described by: ECO:0000212
type: Reaction
reactant: MODEL1310110046#
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
modifier: MODEL1310110046#

metaM fol c
type: Species
is: HMDB00121
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
initial amount: NaN
constant: false
name: Folate

metaR MCLOR
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 3-Mercaptolactate:NAD+ oxidoreductase
reactant: MODEL1310110046#
is: SBO:0000176
product: MODEL1310110046#
kinetic law: MODEL1310110046#
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110046#

http://identifiers.org/biomodels.db/MODEL1310110046#_9a6b5b91_0e44_4891_b359_6976fb141ed3
constant: false
has only substance units: false
name: AADAT
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:51166
boundary condition: true
is: Q4W5N8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110046#_52f41c6a_546f_4373_9011_83e40041b463
has only substance units: false
constant: false
name: SULT1A1
type: Species
is encoded by: hsa:6817
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM 34hpp m
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
initial amount: NaN
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
initial concentration: 1.0
is: CHEBI:36242

http://identifiers.org/biomodels.db/MODEL1310110046#_68d94f93_eb0f_4de1_b3c5_7839ef682c99
name: DECR1
boundary condition: true
constant: false
is: Q16698
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1666

metaR IDOAASE1ly
type: Reaction
kinetic law: MODEL1310110046#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110046#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
modifier: MODEL1310110046#
product: MODEL1310110046#

metaM gdp n
boundary condition: false
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01201
is: SBO:0000247
is: CHEBI:58189
type: Species

metaM ksi deg23 l
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 23
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C124H201N8O106S5 CHARGE: -5